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AIDS Weekly Plus
Researchers from University of Duisburg-Essen Provide Details of New Studies and Findings in the Area of HIV/AIDS
Staff Writer
August 12, 2013


2013 AUG 12 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- New research on Immune System Diseases and Conditions is the subject of a report. According to news reporting originating in Essen, Germany, by NewsRx journalists, research stated, "Co-infection of HIV patients with cytomegalovirus (CMV) is associated with enhanced AIDS progression and CMV end-organ diseases. On the other hand, persistent CMV infection has recently been shown to decrease tumor relapse and protect against lethal bacterial infection."

The news reporters obtained a quote from the research from the University of Duisburg-Essen, "The influence of persistent CMV on the outcome of an acute retroviral superinfection is still unknown. Here we show that a persistent murine CMV (mCMV) infection surprisingly confers higher resistance to a primary Friend retrovirus infection (FV) of mice. Decreased FV titers and augmented FV-specific CD8 T-cell responses were found in mCMV infected mice during primary FV superinfection. NK cells produced higher amounts of IFNgamma after FV infection of persistently mCMV infected mice suggesting that these cells were involved in the 'protective' effect. Depletion of NK1.1(+) cells or neutralization of IFNgamma during FV superinfection abrogated the mCMV-mediated effect. Our data demonstrate for the first time that a persistent CMV infection induces long-lasting NK cell responses that can enhance immunity to primary retroviral infections. To our knowledge, studies investigating primary HIV infection have not analyzed the role of the CMV seropositivity in these patients."

According to the news reporters, the research concluded: "Our observations suggest that NK cells in CMV seropositive individuals might contribute to the control of primary HIV infection."

For more information on this research see: NK cells improve control of friend virus infection in mice persistently infected with murine cytomegalovirus. Retrovirology, 2013;10():1-8. Retrovirology can be contacted at: Biomed Central Ltd, 236 Grays Inn Rd, Floor 6, London WC1X 8HL, England. (BioMed Central - www.biomedcentral.com/; Retrovirology - www.retrovirology.com)

Our news correspondents report that additional information may be obtained by contacting S. Francois, University of Duisburg Essen, Univ Hosp Essen, Inst Virol, Essen, Germany (see also Immune System Diseases and Conditions).

Keywords for this news article include: Essen, Europe, Germany, HIV/AIDS, Virology, DNA Viruses, RNA Viruses, Retroviridae, HIV Infections, Betaherpesvirinae, Vertebrate Viruses, DNA Virus Infections, Primate Lentiviruses, Herpesviridae Infections, Opportunistic Infections, Cytomegalovirus Infections, Viral Sexually Transmitted Diseases

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