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AIDS Weekly Plus
Montefiore Medical Center and Albert Einstein College of Medicine Details Findings in HIV/AIDS
Staff Writer
September 9, 2013

2013 SEP 9 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Current study results on Immune System Diseases and Conditions have been published. According to news originating from Bronx, New York, by NewsRx correspondents, research stated, "Treatment outcomes for multidrug-resistant tuberculosis (MDR-TB) in South Africa have suffered as centralized, in-patient treatment programs struggle to cope with rising prevalence and human immunodeficiency virus (HIV) co-infection rates. A new treatment model is needed to expand treatment capacity and improve MDR-TB and HIV outcomes."

Our news journalists obtained a quote from the research from the Montefiore Medical Center and Albert Einstein College of Medicine, "To describe the design and preliminary results of an integrated, home-based MDR-TB-HIV treatment program created in rural KwaZulu-Natal. In 2008, a decentralized center was established to provide out-patient MDR-TB and HIV treatment. Nurses, community health workers and family supporters have been trained to administer injections, provide adherence support and monitor adverse reactions in patients' homes. Physicians assess clinical response, adherence and the severity of adverse reactions to MDR-TB and HIV treatment at monthly follow-up visits. Treatment outcomes are assessed by monthly cultures and CD4 and viral load every 6 months. Of 80 patients initiating MDR-TB treatment from February 2008 to April 2010, 66 were HIV-co-infected. Retention has been high (only 5% defaults, 93% of visits attended), and preliminary outcomes have been favorable (77% cured/still on treatment, 82% undetectable viral load). Few patients have required escalation of care (9%), had severe adverse events (8%) or died (6%)."

According to the news editors, the research concluded: "Integrated, home-based treatment for MDR-TB and HIV is a promising treatment model to expand capacity and achieve improved outcomes in rural, resource-poor and high HIV prevalent settings."

For more information on this research see: Integrated, home-based treatment for MDR-TB and HIV in rural South Africa: an alternate model of care. The International Journal of Tuberculosis and Lung Disease, 2012;16(8):998-1004 (see also Immune System Diseases and Conditions).

The news correspondents report that additional information may be obtained from J.C. Brust, Montefiore Medical Center & Albert Einstein College of Medicine, Bronx, New York 10467, United States. Additional authors for this research include N.S. Shah, M. Scott, K. Chaiyachati, M. Lygizos, T.L. van der Merwe, S. Bamber, Z. Radebe, M. Loveday, A.P. Moll, B. Margot, U.G. Lalloo, G.H. Friedland and N.R Gandhi.

Keywords for this news article include: Bronx, New York, HIV/AIDS, Treatment, RNA Viruses, Retroviridae, Tuberculosis, United States, HIV Infections, Infectious Disease, Vertebrate Viruses, Primate Lentiviruses, Opportunistic Infections, North and Central America, Human Immunodeficiency Virus, Viral Sexually Transmitted Diseases.

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