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Reports from International Center for Genetic Engineering and Biotechnology Describe Recent Advances in HIV/AIDS
Staff Writer
September 16, 2013


2013 SEP 16 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Investigators publish new report on Immune System Diseases and Conditions. According to news reporting originating in New Delhi, India, by NewsRx journalists, research stated, "Although HIV causes immune deficiency by infection and depletion of immunocytes, metabolic alterations with clinical manifestations are also reported in HIV/AIDS patients. Here we aimed to profile metabolite changes in the plasma, urine, and saliva of HIV/AIDS patients, including those on anti-retroviral therapy (ART)."

The news reporters obtained a quote from the research from International Center for Genetic Engineering and Biotechnology, "Metabolic profiling of biofluids collected from treatment naive HIV/AIDS patients and those receiving ART was done with solution-state nuclear magnetic resonance (NMR) spectroscopy followed by statistical analysis and annotation. In Principal Component Analysis (PCA) of the NMR spectra, Principal Component 1 (PC1) alone accounted for 99.3%, 87.2% and 78.8% variations in plasma, urine, and saliva, respectively. Partial least squares discriminant analysis (PLS-DA) was applied to generate three-component models, which showed plasma and urine to be better than saliva in discriminating between patients and healthy controls, and between ART-naive patients and those receiving therapy. Twenty-six metabolites were differentially altered in any or two types of samples. Our results suggest that urinary Neopterin, and plasma Choline and Sarcosine could be used as metabolic biomarkers of HIV/AIDS infection. Pathway analysis revealed significant alternations in 12 metabolic pathways. This study catalogs differentially regulated metabolites in biofluids, which helped classify subjects as healthy controls, HIV/AIDS patients, and those on ART."

According to the news reporters, the research concluded: "It also underscores the importance of further studying the consequences of HIV infection on host metabolism and its implications for pathogenesis."

For more information on this research see: Nuclear magnetic resonance based profiling of biofluids reveals metabolic dysregulation in HIV-infected persons and those on anti-retroviral therapy. Plos One, 2013;8(5):e64298. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)

Our news correspondents report that additional information may be obtained by contacting S.U. Munshi, Virology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India. Additional authors for this research include B.B. Rewari, N.S. Bhavesh and S. Jameel (see also Immune System Diseases and Conditions).

Keywords for this news article include: Asia, India, Therapy, HIV/AIDS, New Delhi, RNA Viruses, Retroviridae, HIV Infections, Magnetic Resonance, Vertebrate Viruses, Primate Lentiviruses, Viral Sexually Transmitted Diseases, Immune System Diseases and Conditions.

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