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AIDS Weekly Plus
Research Conducted at Veterans Affairs Medical Center Has Updated Our Knowledge about HIV/AIDS
Staff Writer
October 21, 2013


2013 OCT 21 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Researchers detail new data in Immune System Diseases and Conditions. According to news originating from Cincinnati, Ohio, by NewsRx correspondents, research stated, "Pneumocystis pneumonia (PcP) is the second leading cause of morbidity and mortality in human immunodeficiency virus (HIV)-infected patients in the United States. Although the host risk factors for the development of PcP are well established, the environmental (climatological, air pollution) risk factors are poorly understood."

Our news journalists obtained a quote from the research from Veterans Affairs Medical Center, "The major goal of this study was to determine the environmental risk factors for admissions of HIV-positive patients with PcP to a single medical center. Between 1997 and 2008, 457 HIV-positive patients with microscopically confirmed PcP were admitted to the San Francisco General Hospital. A case-crossover design was applied to identify environmental risk factors for PcP hospitalizations. Climatological and air pollution data were collected from the Environmental Protection Agency and Weather Warehouse databases. Conditional logistic regression was used to evaluate the association of each environmental factor and PcP hospital admission. Hospital admissions were significantly more common in the summer than in the other seasons. Increases in temperature and sulfur dioxide levels were independently associated with hospital admissions for PcP, but the effects of sulfur dioxide were modified by increasing carbon monoxide levels. This study identifies both climatological and air pollution constituents as independent risk factors for hospitalization of HIV-positive patients with PcP in San Francisco. Thus, the environmental effects on PcP are more likely complex than previously thought."

According to the news editors, the research concluded: "Further studies are needed to understand how these factors exert their effects and to determine if these factors are associated with PcP in other geographic locations."

For more information on this research see: Environmental risk factors for Pneumocystis pneumonia hospitalizations in HIV patients. Clinical Infectious Diseases, 2013;56(1):74-81. (Oxford University Press - www.oup.com/; Clinical Infectious Diseases - cid.oxfordjournals.org)

The news correspondents report that additional information may be obtained from K. Djawe, Veterans Affairs Medical Center, Cincinnati, OH 45267-0560, United States. Additional authors for this research include L. Levin, A. Swartzman, S. Fong, B. Roth, A. Subramanian, K. Grieco, L. Jarlsberg, R.F. Miller, L. Huang and P.D Walzer (see also Immune System Diseases and Conditions).

Keywords for this news article include: Ohio, HIV/AIDS, Hospital, Chemicals, Chemistry, Pneumonia, Cincinnati, Pulmonology, RNA Viruses, Pneumocystis, Retroviridae, United States, Lung Diseases, HIV Infections, Sulfur Dioxide, Infectious Disease, Vertebrate Viruses, Risk and Prevention, Primate Lentiviruses, Opportunistic Infections, North and Central America.

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