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AIDS Weekly Plus
Data from University Hospital Provide New Insights into HIV/AIDS and Toxoplasmosis

Staff Writer

October 28, 2013

2013 OCT 28 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Current study results on Opportunistic Infections have been published. According to news reporting from Johannesburg, South Africa, by NewsRx journalists, research stated, "Cerebellar mass lesion is an uncommon presentation of toxoplasmosis. The authors report one rare case in an 11-month-old HIV/AIDS female infant who presented with deterioration in her developmental milestones."

The news correspondents obtained a quote from the research from University Hospital, "CT scan revealed a ring-enhancing mass lesion in the right cerebellar hemisphere with secondary obstructive hydrocephalus. A ventriculoperitoneal shunt was inserted prior to posterior fossa decompression and biopsy of the lesion. The specimens obtained were divided into two. One specimen was sent for histological diagnosis immediately after surgery while the second specimen was preserved until the release of the histology report. The initial histopathology report indicated a neoplastic process. Immunohistochemical stains were attempted but interpreted with difficulty due to severe tissue necrosis. After waiting for close to 6 weeks without a definite histological diagnosis, the preserved second specimen was sent for histological analysis as a fresh specimen, and reported a diagnosis of toxoplasmosis. This case presented diagnostic challenges to the authors whose radiological impressions of either a neoplastic lesion or a tuberculoma (based on our local neuroepidemiology) were reinforced by intraoperative findings highly suggestive of tuberculoma but which contrasted with the histological report, first as a neoplastic lesion and later toxoplasmosis."

According to the news reporters, the research concluded: "Although cerebellar toxoplasmosis is a rare complication of HIV/AIDS, this case report shows that toxoplasmosis should not be overlooked as a differential diagnosis of ring-enhancing cerebellar masses in HIV/AIDS patients irrespective of the patient's age and the absence of constitutional symptoms of toxoplasmosis."

For more information on this research see: Cerebellar toxoplasmosis in HIV/AIDS infant: case report and review of the literature. Neurological Sciences, 2012;33(6):1423-8. Neurological Sciences can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer -; Neurological Sciences -

Our news journalists report that additional information may be obtained by contacting K. Ibebuike, Dept. of Neurosurgery, Wits Medical School, Chris Hani Baragwanath Academic Hospital, 7, York Road, Parktown, Johannesburg 2193, South Africa. Additional authors for this research include L. Mantanga, O. Emereole, P. Ndolo, A. Kajee, R. Gopal and S. Pather (see also Opportunistic Infections).

Publisher contact information for the journal Neurological Sciences is: Springer, 233 Spring Street, New York, NY 10013, USA.

Keywords for this news article include: HIV/AIDS, RNA Viruses, Johannesburg, South Africa, Retroviridae, Toxoplasmosis, HIV Infections, Toxoplasma gondii, Vertebrate Viruses, Primate Lentiviruses, Opportunistic Infections, Viral Sexually Transmitted Diseases.

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