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AIDS Weekly Plus
Findings from University of Alabama Broaden Understanding of HIV/AIDS
Staff Writer
November 4, 2013


2013 NOV 4 (NewsRx) -- By a News Reporter-Staff News Editor at AIDS Weekly -- Data detailed on Immune System Diseases and Conditions have been presented. According to news reporting originating in Birmingham, Alabama, by NewsRx editors, the research stated, "Infections due to Cryptococcus species occur globally and in a wide variety of hosts, ranging from those who are severely immunosuppressed to those who have phenotypically 'normal' immune systems. Approximately 1 million cases of cryptococcosis occur throughout the world, and is it estimated that there are 650,000 associated deaths annually."

The news reporters obtained a quote from the research from the University of Alabama, "Most of these cases occur among patients with advanced HIV disease, but a growing number occur among solid organ transplant recipients and others receiving exogenous immunosuppression, patients with innate and acquired immunodeficiency, and otherwise immunologically normal hosts. Much of our recent knowledge is solely derived from clinical experience over the last 2 to 3 decades of cryptococcosis among HIV-infected patients. However, based on recent observations, it is clear that there are substantial differences in the epidemiology, clinical features, approaches to therapy, and outcome when comparing HIV-infected to non-HIV-infected individuals who have cryptococcosis. If one carefully examines cryptococcosis in the three largest subgroups of patients based on host immune status, specifically, those with HIV, solid organ transplant recipients, and those who are non-HIV, non-transplant (NHNT) infected persons, then one can observe very different risks for infection, varied clinical presentations, long-term complications, mortality, and approaches to therapy."

According to the news reporters, the research concluded: "This article focuses on cryptococcosis in the non-HIV-infected patient, including a brief review of ongoing events in the Pacific Northwest of the United States and Canada relative to the outbreak of Cryptococcus gattii infections among a largely immunologically normal population, and highlights some of the key insights and questions which have emerged as a result of these important new observations."

For more information on this research see: Cryptococcal infections in non-hiv-infected patients. Transactions of the American Clinical and Climatological Association, 2013;124():61-79 (see also Immune System Diseases and Conditions).

Our news correspondents report that additional information may be obtained by contacting P.G. Pappas, Division of Infectious Diseases, University of Alabama at Birmingham, 1900 University Blvd, 229 THT, Birmingham, AL 35294-0006, United States.

Keywords for this news article include: Alabama, Therapy, HIV/AIDS, Birmingham, RNA Viruses, Retroviridae, United States, Cryptococcosis, HIV Infections, Vertebrate Viruses, Primate Lentiviruses, Opportunistic Infections, North and Central America, Viral Sexually Transmitted Diseases, Immune System Diseases and Conditions.

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