1990

Too little, too late. [videorecording].: [United States] : Micki Dickoff, c1987 1 videocassette (48 min.) : sd., col. with b&w ; 1/2 in Unique Identifier : AIDSLINE AV/9001259A; Dickoff M; (Producer) For every AIDS patient, according to one authority, the lives of at least eight family members and close friends are profoundly affected. Isolated and frequently shunned, these mothers and fathers, brothers and sisters, lovers and friends can feel as if they have nowhere to turn, and must endure their loss
Care of HIV-infected children. [videorecording]: [Los Angeles, Calif.] : The Network, c1988 1 videocassette (28 min., 30 sec.) : sd., col. ; 1/2 in. + 1 guide Unique Identifier : AIDSLINE AV/9001318A; Boland M; (Producer) Focuses on nursing care of HIV-infected infants and children and a model based on patient and family needs throughout the course of the illness. Illustrates a nursing care plan for HIV-infected children and reviews common problems. Emphasizes observance of Universal Precautions.
Coping with AIDS : some personal experiences of people with AIDS & HIV. [videorecording]: Services Lambeth [England] : Lambeth Council, c1988 1 videocassette (60 min.) : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/9001322A; (Producer) People with AIDS face an array of physical, psychological, social, and practical problems. These problems are not just limited to dealing with consequences of the illness, but also concern the responses they receive from their families and friends and providers of health care and social services. The aim
AIDS. [slide]: London, UK : Gower, c1989 155 slides : col. with b&w + 1 guide + 1 text (Essential slide collection) Unique Identifier : AIDSLINE AV/9001219A; Williams I; Mindel A; Weller I
Early HIV. [slide]: [Columbus, Ohio] : The Center, [1989] 29 slides : col. + 1 sound cassette (1 7/8 ips) + 1 guide (OMEN ; no. 31) Unique Identifier : AIDSLINE AV/9001231A; Koletar SL; Crane R
The:Acquired immunodeficiency syndrome. [slide].: New York, N.Y. : Gower Medical Pub., c1989 90 slides : col. with b&w + 1 guide (Slide atlas of sexually transmitted diseases ; unit 8) Unique Identifier : AIDSLINE AV/9001263A; Kozarsky PE; Blumberg HM; DuPuis MH
Eyes. [slide].: New York, NY : Gower Medical Pub., c1989 33 slides : col. with b&w + 1 guide (Slide atlas of pathology of AIDS ; 6) Unique Identifier : AIDSLINE AV/9001287A; Ioachim HL
GI tract, associated organs. [slide].: New York, NY : Gower Medical Pub., c1989 88 slides : col. with b&w + 1 guide (Slide atlas of pathology of AIDS ; 4) Unique Identifier : AIDSLINE AV/9001289A; Ioachim HL
HIV counseling and testing : the physician's role. [videorecording]: Chicago, Ill. : The Society, c1989 1 videocassette : sd., col. ; 1/2 in. + 1 guide Unique Identifier : AIDSLINE AV/9001292A
Respiratory. [slide].: New York, NY : Gower Medical Pub., c1989 67 slides : col. with b&w + 1 guide (Slide atlas of pathology of AIDS ; 3) Unique Identifier : AIDSLINE AV/9001301A; Ioachim HL
Skin, hematolymphopoietic, cardiovascular. [slide].: New York, NY : Gower Medical Pub., c1989 94 slides : col. with b&w + 1 guide (Slide atlas of pathology of AIDS ; 2) Unique Identifier : AIDSLINE AV/9001303A; Ioachim HL
Slide atlas of pathology of AIDS. [slide].: New York, NY : Gower Medical Pub., c1989 453 slides : col. with b&w + 6 guides Unique Identifier : AIDSLINE AV/9001305A; Ioachim HL
Textbook of AIDS pathology. [slide].: New York, NY : Gower Medical Pub., c1989 80 slides : col. with b&w + 1 guide (Slide atlas of pathology of AIDS ; 1) Unique Identifier : AIDSLINE AV/9001309A; Ioachim HL
Urinary, genital, endocrine, CNS. [slide].: New York, NY : Gower Medical Pub., c1989 91 slides : col. with b&w + 1 guide (Slide atlas of pathology of AIDS ; 5) Unique Identifier : AIDSLINE AV/9001313A; Ioachim HL
[SIDA-AIDS : o que cada um deve saber para a combater.]: Portugal : Publicacoes Europa-America, c1986 171 p (Arte de viver ; 118) Unique Identifier : AIDSLINE CAT/9014591; Bernex R
AIDS in the Sudan : guide lines.: Khartoum : Sudan National AIDS Committee, [1987] 38 p Unique Identifier : AIDSLINE CAT/9013954; El-Tigani A; Eltayeb ES; Elmagzoub A
Acquired immune deficiency syndrome (AIDS) in Massachusetts : workplace issues, rights, and responses : a report of the Senate Committee on Post Audit and Oversight.: and Oversight Bureau [Boston, MA] (Room 314, State House, Boston, 02133) : The Committee, [1987] iv, 56 p Unique Identifier : AIDSLINE CAT/9014646
AIDS/HIV infection policy : ensuring a safe hospital environment : report and recommendations of the Special Committee on AIDS/HIV Infection Policy.: Infection Policy [Washington, D.C.] : American Hospital Association, [1987] viii, 20, 2 p (AHA report) Unique Identifier : AIDSLINE CAT/9014660
Strategies for screening blood for HIV antibody : use of a decision support system.: Philadelphia, Pa. : Leonard Davis Institute of Health Economics, University of Pennsylvania, [1987] 23, [8] leaves : ill (LDI management discussion paper ; no. 63) Unique Identifier : AIDSLINE CAT/9014862; Schwartz JS
Partners in prevention : a media worker's guide to AIDS. 3rd ed., wholly rev.: Carlton South, Vic. : Designer Publications on behalf of the Australian Federation of AIDS Organisations, c1988 49 p Unique Identifier : AIDSLINE CAT/9014094; Carr A
AIDS and development : implications for Australian non-government aid agencies.: Canberra : Australian Council for Overseas Aid, [1988] 50 p (Development dossier, ISSN 0815-9424 ; no. 24) Unique Identifier : AIDSLINE CAT/9014363; Reid E
[AIDS : chega de medo, vamos matar o virus da ignorancia.]: Rio de Janeiro : Associacao Brasileira de Entidades de Planejamento Familiar, 1988 91 p (Cadernos ABEPF ; 6) Unique Identifier : AIDSLINE CAT/9014365
Self-treatment for AIDS : oxygen therapies, etc.: San Francisco, Calif. (1600 Larkin, no. 104, San Francisco 94109) : [Greensward Press], c1988 152 p. : ill., ports Unique Identifier : AIDSLINE CAT/9014574; Russell-Manning B
AIDS and the workplace : a practical approach.: North Ryde, N.S.W. : CCH Australia, c1989 vii, 188 p Unique Identifier : AIDSLINE CAT/9013953; Tillett G
Confronting AIDS on the campus and in the classroom : a guide for higher education.: Washington, D.C. : College and University Personnel Association, c1989 viii, 222 p Unique Identifier : AIDSLINE CAT/9013982; McClain JR; Matteoli TE
[Cronicas do tempo de uma peste : a AIDS : materias educativas e informativas, com posicionamentos pessoais.]: Sao Paulo, SP : Roca, 1989 viii, 91 p Unique Identifier : AIDSLINE CAT/9013985; Amato Neto V
Food programs : assessing and developing community-based nutritional support programs for people with HIV-related illness.: Washington, DC : National AIDS Network (2033 M St., NW, Suite 800, Washington, DC, 20036), c1989 v. : ill (NAN technical assistance series) Unique Identifier : AIDSLINE CAT/9014009; Korda H; Hall CS
Shattered mirrors : our search for identity and community in the AIDS era.: Cambridge, Mass. : Harvard University Press, 1989 159 p Unique Identifier : AIDSLINE CAT/9014135; Price ME
Women and AIDS : a practical guide for those who help others.: New York : Continuum, 1989 xiii, 143 p (The Continuum counseling series) Unique Identifier : AIDSLINE CAT/9014171; Lester B
AIDS, agencies and drug abuse : the Edinburgh experience.: Norwich : Social Work Monographs, 1989 40 leaves (Social work monograph series) Unique Identifier : AIDSLINE CAT/9014203; McRae J
[Atlante di clinica e laboratorio, AIDS = AIDS, clinical and laboratory atlas.]: Pavia : Edizioni Medico-Scientifiche, c1989 vii, 405 p. : ill Unique Identifier : AIDSLINE CAT/9014359; Rondanelli EG
AIDS : sexual behavior and intravenous drug use.: Washington, D.C. : National Academy Press, 1989 (1990 printing) xiii, 589 p. : ill Unique Identifier : AIDSLINE CAT/9014364; Turner CF; Miller HG; Moses LE; the Behavioral, Social, and Statistical Sciences
Guide to planning health promotion for AIDS prevention and control.: Geneva : World Health Organization, 1989 iv, 71 p. : ill (WHO AIDS series, ISSN 1011-5773 ; 5) Unique Identifier : AIDSLINE CAT/9014445
Policing desire : pornography, AIDS, and the media. 2nd ed.: Minneapolis : University of Minnesota Press, 1989 xiii, 167 p. : ill (Media & society) Unique Identifier : AIDSLINE CAT/9014529; Watney S
Pediatric AIDS : report of the Twentieth Ross Roundtable on Critical Approaches to Common Pediatric Problems.: Problems Columbus, Ohio : Ross Laboratories (625 Cleveland Ave., Columbus 43216), c1989 viii, 83 p. : ill (Ross Roundtable report) Unique Identifier : AIDSLINE CAT/9014811
Pharmacia anti-HIV assays : data presented at V International Conference on AIDS, Montreal, 1989.: Uppsala, Sweden ; Columbia, Md., USA : Pharmacia ENI Diagnostics, [1989] 23 p. : ill Unique Identifier : AIDSLINE CAT/9014814
Protocol 1, estimating the use and costs of medical, social, and support services for persons with AIDS and ARC.: Rockville, MD (18-12 Parklawn Bldg., Rockville 20857) : U.S. Dept. of Health and Human Services, Public Health Service, National Center for Health Services Research and Health Care Technology Assessment, [1989] iv, 139 p. : ill (NCHSR program note) Unique Identifier : AIDSLINE CAT/9014829; Scitovsky AA; Technology Assessment (U.S.)
Protocol 3, comparisons of the cost effectiveness of alternative models for organizing services for person with AIDS.: Rockville, MD : The Center ; Springfield, VA : Available from National Technical Information Service, [1989] 88 p (NCHSR program note) Unique Identifier : AIDSLINE CAT/9014285; Knickman J; Benjamin AE; Dunham NC; Technology Assessment (U.S.)
Guidelines on AIDS and first aid in the workplace.: Geneva : World Health Organization, 1990 iii, 12 p (WHO AIDS series, ISSN 1011-5773 ; 7) Unique Identifier : AIDSLINE CAT/9014017
Syphilis as AIDS.: Austin, Tex. : Banned Books, c1990 xx, 128 p Unique Identifier : AIDSLINE CAT/9014149; Mitchell RB
The:AIDS benefits handbook : everything you need to know to get social security, welfare, Medicaid, Medicare, food stamps, housing, drugs, and other benefits.: New Haven : Yale University Press, c1990 xiv, 257 p Unique Identifier : AIDSLINE CAT/9014202; McCormack TP
National AIDS manual. 2nd rev. ed.: London : NAM Publications, 1990- 2 v. (loose-leaf) Unique Identifier : AIDSLINE CAT/9014265; Scott P
Skin manifestations of AIDS.: London : M. Dunitz, 1990 ix, 210 p : ill Unique Identifier : AIDSLINE CAT/9014576; Penneys NS
Vaccines 90 : modern approaches to new vaccines including prevention of AIDS.: Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press, 1990 xxv, 502 p. : ill Unique Identifier : AIDSLINE CAT/9014619; Brown F
Dancing against the darkness : a journey through America in the age of AIDS.: Lexington, Mass. : Lexington Books, c1990 xxviii, 218 p Unique Identifier : AIDSLINE CAT/9014701; Petrow S
Our responses to a deadly virus : the group-analytic approach.: London : Published by Karnac Books for the Institute of Group Analysis and the Group-Analytic Society, 1990 xix, 220 p. : ill., port Unique Identifier : AIDSLINE CAT/9014805; Molnos A
Report.: Pacific AIDS Manila, Philippines : Printed and distributed by the Regional Office for the Western Pacific of the World Health Organization, [1990] 15 p Unique Identifier : AIDSLINE CAT/9014839
Updated forecasts of the costs of medical care for persons with AIDS, 1989-93.: Rockville, MD (18-12 Parklawn Bldg., Rockville 20857) : U.S. Dept. of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research, [1990] 12 p (AHCPR program note) Unique Identifier : AIDSLINE CAT/9014877; Hellinger FJ
The:Human retroviruses.: San Diego : Academic Press, c1991 xviii, 421 p. : ill Unique Identifier : AIDSLINE CAT/9014034; Gallo RC; Jay G
SECOND ANNUAL MEETING OF THE NATIONAL COOPERATIVE VACCINE DEVELOPMENT GROUPS FOR AIDS, OCTOBER 15-18, 1989, FORT LAUDERDALE, FL: Second Annual Meeting of the National Cooperative Vaccine Development Groups for AIDS. October 15-18, 1989, Fort Lauderdale, FL, Vaccine Research and Development Branch, Division of AIDS, NIAID, 1989.. Unique Identifier : AIDSLINE ICDB/90649240; Anonymous; No affiliation given; The second annual meeting of the National Cooperative Vaccine Development Groups (NCVDGs) for AIDS was held October 15-18, 1989, in Fort Lauderdale, Florida. Topics included the HIV genome: opportunity/obstacles for AIDS vaccine development; the HIV Vaccine Consortium; idiotype-based vaccines for controlling HIV infec
PRINCIPLES OF CARCINOGENESIS: VIRAL: Cancer: Principles and Practice of Oncology. Third Edition. DeVita VT Jr. et al, eds. Philadelphia, Lippincott, p. 149-66, 1989.. Unique Identifier : AIDSLINE ICDB/90666955; Howley PM; Lab. of Tumor Virus Biology, NCI, Bethesda, MD; The observation that cell-free extracts from a sarcoma in chickens could transmit sarcoma to injected animals was made by Peyton Rous in 1911. That this represented viral transmission of cancer was not appreciated for decades. Several human viruses have oncogenic properties, although not all have been demonstrated to
HODGKIN'S DISEASE: Cancer: Principles and Practice of Oncology. Third Edition. DeVita VT Jr. et al, eds. Philadelphia, Lippincott, p. 1696-740, 1989.. Unique Identifier : AIDSLINE ICDB/90666996; Hellman S; Jaffe ES; DeVita VT Jr; Univ. of Chicago, Chicago, IL; Between 7000 and 7500 patients (pts) are diagnosed with Hodgkin s disease (HD) annually in the United States . HD is reviewed under the following headings: etiology and epidemiology; history; pathology (classification, criteria for histologic diagnosis, and cellular origin); natural his
CUTANEOUS LYMPHOMAS: Cancer: Principles and Practice of Oncology. Third Edition. DeVita VT Jr. et al, eds. Philadelphia, Lippincott, p. 1799-808, 1989.. Unique Identifier : AIDSLINE ICDB/90666998; Bunn PA; Fuks Z; Div. of Medical Oncology, Univ. of Colorado, Health Sciences; Center, University Hosp., Denver, CO; T-cell lymphomas are much less common than B-cell lymphomas in patients (pts) in the united States. Cutaneous T-cell lymphoma (CTCL) has an age-adjusted incidence in the United States of 2-3 cases per million persons per year. Acute T-cell leukemia/lymphoma (ATL), which is caused by hu
CANCER IN AIDS AND OTHER IMMUNODEFICIENCY STATES: Cancer: Principles and Practice of Oncology. Third Edition. DeVita VT Jr. et al, eds. Philadelphia, Lippincott, p. 1953-70, 1989.. Unique Identifier : AIDSLINE ICDB/90667004; Groopman JE; Broder S; Div. of Hematology/Oncology, New England Deaconess Hosp., Boston,; MA; In humans, various conditions characterized by impaired immune function are associated with a higher frequency of certain cancers than occur in age-matched controls. Certain immunodeficiency states and their relation to cancer are discussed under the following headings: cancer in allotransplant recipients, cancer in p
MOLECULAR REGULATION OF T LYMPHOCYTE ACTIVATION: Adv Regul Cell Growth; 1:93-118 1989. Unique Identifier : AIDSLINE ICDB/90667930; Edwards CA; Crabtree GR; Molecular Virology Group, Genelabs, Inc., 505 Penobscot Drive,; Redwood City, CA 94063; The interaction of a specific antigen with its cognate antigen receptor in a quiescent T lymphocyte initiates the T-cell immune response. The recognition of antigen at the cell surface triggers second messengers to carry this information to the nucleus and to activate the expression of several genes. Before a T lympho
THE EPIDEMIOLOGY OF AIDS: EXPRESSION, OCCURRENCE, AND CONTROL OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INFECTION: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, 359 p., 1989.. Unique Identifier : AIDSLINE ICDB/90668107; Anonymous; No affiliation given; By late 1988, the number of articles cataloged in the National Library of Medicine AIDS Bibliography reached nearly 500 per month. The present volume seeks to assemble the available information on the epidemiology of HIV-1 infection into a coherent framework, accessible to the largest possible number of professionals
THE NERVOUS SYSTEM: PATHOPHYSIOLOGY AND CLINICAL MANIFESTATIONS: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 68-83, 1989.. Unique Identifier : AIDSLINE ICDB/90668112; Brew B; Sidtis JJ; Price R; Dept. of Neurology, Memorial Sloan-Kettering Cancer Center, New; York, NY 10021; The course of infection by HIV-1 commonly is complicated by both CNS and peripheral nervous system (PNS) disorders that contribute importantly to its morbidity. The commonest and clinically most important of these disorders are reviewed. Topics include CNS disorders known or suspected to relate to direct HIV-1 infecti
EPIDEMIOLOGY OF AIDS: GENERAL CONSIDERATIONS: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 87-116, 1989.. Unique Identifier : AIDSLINE ICDB/90668113; Kaslow RA; Francis DP; NIAID, NIH, Westwood Bldg., Rm. 739, Bethesda, MD 20892; Many epidemiologic features of HIV-1 infection and AIDS are pertinent to the epidemic as a whole rather than peculiar to any of the risk groups individually. General issues common to the HIV-1 epidemic are reviewed, including origins of HIV-1 infection; AIDS occurrence and surveillance; transmission (transmissibility
THE EPIDEMIOLOGY OF AIDS: HETEROSEXUALS: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 136-52, 1989.. Unique Identifier : AIDSLINE ICDB/90668115; Haverkos HW; Edelman R; Natl. Inst. on Drug Abuse, Parklawn Bldg, Rm. 10A08, 5600 Fishers; Lane, Rockville, MD 20857; Early in the history of the AIDS epidemic, sexual transmission from men to women was considered unlikely or uncommon. Subsequent records of transmission of HIV-1 from men to women among unmarried women in Africa, spouses of the military, and hemophiliacs rapidly changed this misconception. The epidemiology of HIV-1 in
THE EPIDEMIOLOGY OF AIDS: PARENTERAL DRUG USERS: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 153-78, 1989.. Unique Identifier : AIDSLINE ICDB/90668116; Friedland G; Montefiore Medical Center, Albert Einstein Coll. of Medicine, 111; E. 210th St., Bronx, NY 10467; Three features of illicit drug use during the past century have provided a fertile field for the amplification of HIV transmission: (1) an epidemic of drug use; (2) a change to the iv method of administration; and (3) an increase in needle-sharing behavior. The epidemiology of AIDS among parenteral drug users is revie
THE EPIDEMIOLOGY OF AIDS: RECIPIENTS OF BLOOD AND BLOOD PRODUCTS: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 179-93, 1989.. Unique Identifier : AIDSLINE ICDB/90668117; Peterman T; Allen J; Center for Prevention Services, Freeway Park, CDC, Atlanta, GA; 30333; Transfusion recipients are exposed to blood from only a few donors, whereas hemophiliacs (ie, clotting-factor recipients) have extensive donor exposure because clotting factor is concentrated from thousands of donors. Recipients of clotting factor have a seroprevalence rate 1,000 times that of transfusion recipients,
HIV-1 INFECTION AND AIDS IN AFRICA: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 194-220, 1989.. Unique Identifier : AIDSLINE ICDB/90668118; Quinn TK; Mann J; Johns Hopkins Hosp., 600 North Wolfe St., Blalock 1111,; Baltimore, MD 21205; As of February 1988, 39 African countries had reported over 10,000 cases of AIDS, but these figures underestimate the true number of AIDS cases because of problems associated with obtaining an accurate diagnosis. Seroprevalence rates in some areas range from 5-15% among pregnant women and blood donors and up to 20-80%
HIV-1 INFECTION AND AIDS IN HAITI: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 221-30, 1989.. Unique Identifier : AIDSLINE ICDB/90668119; Pape JW; Johnson WD Jr; Div. of International Medicine, Cornell Univ. Medical Coll.,; A431, 1300 York Ave., New York, NY 10021; The first cases of AIDS in Haiti were recognized in 1978-1979, a period that coincides with the earliest reports of AIDS in the United States . Current data are consistent with the hypothesis that AIDS originated in Africa, was subsequently brought to
PERINATAL HIV-1 INFECTION: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 231-41, 1989.. Unique Identifier : AIDSLINE ICDB/90668120; Rogers M; Center for Infectious Diseases, Bldg. 6, Rm. 285, CDC, Atlanta,; GA 30333; AIDS in children was first described in 1982 by physicians in New York City, New Jersey, and Miami. As of August 1988, 1142 children under 13 yr of age with AIDS had been reported to the Centers for Disease Control (CDC), accounting for about 2% of all reported AIDS cases. Most (78%) of these children had acquired HIV
HIV-1 INFECTION IN LOW-RISK POPULATIONS: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 242-9, 1989.. Unique Identifier : AIDSLINE ICDB/90668121; Saah AJ; Dept. of Epidemiology, Johns Hopkins Univ., Baltimore, MD 21205; Several types of contact with HIV-1-infected persons fall between casual contact and intensive, repeated exposure to blood or secretions. Individuals having contact at this intermediate level are considered at low risk for HIV-1 infection. Such persons include health care workers, correctional facilities personnel, da
THE EPIDEMIOLOGY OF AIDS: CHEMOTHERAPY AND CHEMOPROPHYLAXIS: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 282-308, 1989.. Unique Identifier : AIDSLINE ICDB/90668124; Skowron G; Merigan TC; Div. of Infectious Diseases, Stanford Univ. Sch. of Medicine,; Stanford, CA 94305; Therapeutic agents against HIV-1 can be divided broadly into those that specifically inhibit HIV-1 (antivirals) and those that augment the body s own defenses against HIV-1 infection (immunomodulators); some agents show dual activity. Chemotherapy against HIV-1 is reviewed and attempts at chemoprophylaxis are discusse
THE EPIDEMIOLOGY OF AIDS: IMMUNIZATION: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 309-12, 1989.. Unique Identifier : AIDSLINE ICDB/90668125; Francis DP; Dept. of Health Services, State of California, Berkeley, CA 94704; Immunization against HIV-1 can take three forms: (1) pre-exposure, active immunization; (2) post-exposure, active immunization; and (3) post-exposure, passive immunization. Progress in each of these areas is discussed. Vaccine development has been slowed by the limited understanding of the natural history of HIV-1 inf
EXPRESSION AND FUNCTIONAL DOMAINS OF THE TRANSFORMING PROTEIN OF AVIAN SARCOMA VIRUS UR2: Diss Abstr Int [B]; 51(1):77 1990. Unique Identifier : AIDSLINE ICDB/90667067; Jong SJ; Rockefeller Univ.; In order to study the mechanisms of cell transformation by the avian sarcoma virus UR2 which contains the oncogene ros, antibodies against its product P68gag-ros were developed. They were raised against ros-specific oligo- and poly-peptides. The antibodies were used to monitor the expression of potential c-ros product
SYSTEM DYNAMICS ANALYSIS OF THE IMMUNOLOGICAL RESPONSE TO VIRAL INFECTION, WITH PARTICULAR REFERENCE TO THE PATHOGENESIS OF ACQUIRED IMMUNE DEFICIENCY SYNDROME: Diss Abstr Int [B]; 51(2):654 1990. Unique Identifier : AIDSLINE ICDB/90668480; Whitaker RED; Boston Univ.; The mechanisms essential to the pathogenesis of Human Immunodeficiency Virus (HIV) infection have been extremely difficult to determine to date. The magnitude and breadth of immunological abnormalities and the conundrum of a relatively low viral load in the presence of high titres of HIV-specific anti-viral antibodies
INVOLVEMENT OF G PROTEINS AND CAMP-DEPENDENT PROTEIN KINASES IN THE SIGNAL TRANSDUCTION PATHWAY FOR INTERLEUKIN 1: Diss Abstr Int [B]; 51(2):650 1990. Unique Identifier : AIDSLINE ICDB/90668489; Chedid M; Wake Forest Univ., Bowman Gray Sch. of Medicine; Interleukin 1 (IL1) is a macrophage-derived cytokine that stimulates a broad spectrum of immune and inflammatory responses. The main objective of this thesis is to delineate the steps involved in the signal-transduction pathway for IL1. We characterized the IL1 receptor on human rheumatoid synovial cells. G proteins a
FUNCTIONAL DOMAINS OF THE C-ABL PROTEIN TYROSINE KINASE: Diss Abstr Int [B]; 51(3):1119 1990. Unique Identifier : AIDSLINE ICDB/90668532; Jackson PK; Harvard Univ.; Abelson murine leukemia virus is an oncogenic retrovirus capable of inducing a pre-B cell leukemia. The transforming ability of Abelson virus requires its gene product, pp160v-(abl), a cytoplasmic tyrosine kinase. Abelson virus can transform bone marrow in vitro and cultured cells, notably fibroblasts. The v-abl gene
MOLECULAR GENETIC ANALYSES OF THREE LEUKOCYTE SURFACE GLYCOPROTEINS: CD4, LEU-8 AND CD27: Diss Abstr Int [B]; 51(3):1113 1990. Unique Identifier : AIDSLINE ICDB/90668533; Camerini DPJ; Harvard Univ.; We have studied three molecules found on the surface of cells in the human immune system. CD4, Leu-8/TQ1 and CD27 are glycoproteins found on T lymphocytes, the cells which in large part regulate the body s immune defenses. Each of these molecules participates in a different aspect of T cell function. CD4 is part of th
A NOVEL SYSTEM FOR GENERATING PRIMATE RECOMBINANT HYBRID VIRIONS: Diss Abstr Int [B]; 51(3):1129 1990. Unique Identifier : AIDSLINE ICDB/90668550; Wilson CA; George Washington Univ.; The host range of a retrovirus, as determined by the cell types and species that it may infect, is a critical component of viral pathogenicity. The interaction of a retrovirus, via the envelope, with a specific cellular receptor is one of the key factors which determine the viral host range. Retroviral gene transfer t
DEATH WORK: STAFF PERSPECTIVES ON THE CARE OF TERMINALLY ILL PATIENTS IN AN ACUTE CARE HOSPITAL: Diss Abstr Int [A]; 51(3):1002 1990. Unique Identifier : AIDSLINE ICDB/90668578; Goodman HG; City Univ. of New York; This dissertation is a qualitative study of the perspectives of doctors, nurses, and social workers on terminally ill patients (pts) in their care. The methods used for this study were participant observation and focused interviews with professionals about dying pts whom they identified as difficult to manage. Fifteen
PAIN AND HIV INFECTION IN CHILDREN (MEETING ABSTRACT): J Pain Symptom Manage; 4(4):S5 1989. Unique Identifier : AIDSLINE ICDB/90666517; Veber F; Halpern-Weil F; Blanche S; Griscelli C; Hopital des Enfants Malades, Paris, France; Babies and children infected by HIV virus may have symptoms evocative of pain. The causes are diverse, including etiologies other than the classical ones such Candida esophagitis causing pain during deglutition or infectious diarrhea provoking abdominal pain for which cause and reliability of the pain are recognized a
Control of acute and chronic HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):134 (abstract no. Th.A.1). Unique Identifier : AIDSLINE ICA6/10000190; Martin MA; Laboratory of Molecular Microbiology, NIAID, National Institutes; of Health, Bethesda, MD, USA
Regulatory genes of HIV.: Int Conf AIDS. 1990 Jun 20-23;6(1):134 (abstract no. Th.A.2). Unique Identifier : AIDSLINE ICA6/10000290; Pavlakis GN; National Cancer Institute, National Institutes of Health,; Bethesda, MD, USA
Mechanism of HIV tat and HTLV tax.: Int Conf AIDS. 1990 Jun 20-23;6(1):134 (abstract no. Th.A.3). Unique Identifier : AIDSLINE ICA6/10000390; Jeang KT; Laboratory of Molecular Biology, National Institute of Allergy; and Infectious Diseases, NIH, Bethesda, MD, USA
Cellular factors affecting HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):134 (abstract no. Th.A.4). Unique Identifier : AIDSLINE ICA6/10000490; Gaynor R; UCLA, CA, USA
Structure and function of HIV envelope.: Int Conf AIDS. 1990 Jun 20-23;6(1):135 (abstract no. Th.A.5). Unique Identifier : AIDSLINE ICA6/10000590; Sodroski J; Dana-Farber Cancer Institute, Boston, MA, USA
Accessory genes in HIV replication.: Int Conf AIDS. 1990 Jun 20-23;6(1):135 (abstract no. Th.A.6). Unique Identifier : AIDSLINE ICA6/10000690; Haseltine W; Dana-Farber Cancer Institute, Boston, MA, USA
The use of PCR in HIV research.: Int Conf AIDS. 1990 Jun 20-23;6(1):136 (abstract no. Th.A.9). Unique Identifier : AIDSLINE ICA6/10000990; Sninsky J; Emeryville, CA, USA
A rapid method for detection and differentiation of amplified HIV-1 and HIV-2 DNA using a sensitive chemiluminescent DNA probe system (HPA).: Int Conf AIDS. 1990 Jun 20-23;6(1):136 (abstract no. Th.A.10). Unique Identifier : AIDSLINE ICA6/10001090; McDonough S; Brown V; Ryder T; Ou CY; Schochetman G; Gen-Probe, Inc., San Diego, California, USA; OBJECTIVE: As the occurrence of HIV-2 infection increases among the population, the need for differentiation of HIV-1 and HIV-2 becomes more important. The objective of this work was to apply the Hybridization Protection Assay (HPA) to the differentiation of amplified HIV-1 and HIV-2 DNA. METHODS: HPA using DNA probes
Silent HIV infection: a rare occurrence in a high risk heterosexual population.: Int Conf AIDS. 1990 Jun 20-23;6(1):136 (abstract no. Th.A.11). Unique Identifier : AIDSLINE ICA6/10001190; Sullivan JL; Brettler DB; Somasundaran M; Koup RA; Forsberg A; Brewster F; Byron KS; Chattopadyay B; University of Massachusetts Medical School and Medical Center of; Central Massachusetts-Memorial, Worcester, MA, USA; OBJECTIVE: To study the natural history of HIV infection in high-risk sexual partners of HIV infected hemophiliac men. METHOD: Sixty female spouses and/or sexual partners of HIV infected hemophiliac men have been followed for one year to five years following seroconversion in the infected male. Assessment for HIV infe
Resolution of western blot-indeterminate and high risk seronegative blood donors by PCR.: Int Conf AIDS. 1990 Jun 20-23;6(1):136 (abstract no. Th.A.12). Unique Identifier : AIDSLINE ICA6/10001290; Eble B; Busch M; Hurt M; Nason M; Garner J; Guiltinan A; Vyas G; Khayam-Bashi H; University of California, San Francisco, California, USA; OBJECTIVE: Employ polymerase chain reaction amplification (PCR) as a confirmatory assay in order to resolve HIV or HTLV western blot-indeterminate serological results and as a means of screening high-risk seronegative individuals for occult HIV infection. METHODS: Peripheral blood mononuclear cell preparations from se
Detection of HIV-1 infected individuals in a seronegative high-risk population by polyclonal B cell activation in vitro.: Int Conf AIDS. 1990 Jun 20-23;6(1):137 (abstract no. Th.A.13). Unique Identifier : AIDSLINE ICA6/10001390; Sell K; Yehuda-Cohen T; Slade B; Powell J; Villinger F; McClure H; Ansari A; Emory University Sch. of Med., Atlanta, GA, USA; OBJECTIVE: To determine if polyclonal activation of B cells in vitro leads to the secretion of anti HIV-1 reactive antibodies. METHODS: PBMC from a total of 215 individuals from a high-risk patient population at Grady Memorial Hospital were cultured in vitro with pokeweed mitogen (PWM) for 5 days. Serum and supernatan
Early detection of HIV infection by PCR before seroconversion in multitransfused seronegative hemophiliacs and sexual partners.: Int Conf AIDS. 1990 Jun 20-23;6(1):137 (abstract no. Th.A.14). Unique Identifier : AIDSLINE ICA6/10001490; Moncany ML; Berthier A; Ferris S; Montagnier L; Unite d'Oncologie Virale, Institut Pasteur, Paris, France; Limitations of the available serological tests led us to study by PCR a heterogenous at risk population composed of paradoxical seronegative hemophiliacs and of seronegative partners of seropositive patients. We designed a complete set of primers covering the entire genomes of the HIV1 and of the HIV2. They were teste
Enzyme-linked immunospot (ELISPOT) and PCR for the diagnosis of HIV infection in infants.: Int Conf AIDS. 1990 Jun 20-23;6(1):137 (abstract no. Th.A.15). Unique Identifier : AIDSLINE ICA6/10001590; Lee FK; Ou CY; Nesheim SR; Jones D; Schochetman G; Nahmias AJ; Emory University School of Medicine, Atlanta, GA, USA; OBJECTIVE: To evaluate and compare ELISPOT, a new immunological technique, and polymerase chain reaction (PCR) for the early diagnosis of HIV infection in infants. METHODS: Peripheral blood mononuclear cells (PBMC) from 62 infants born to seropositive mothers were prospectively tested for HIV antibody-secreting cells
Mixed HIV-1/HIV-2 infection in Brazil confirmed by PCR analysis.: Int Conf AIDS. 1990 Jun 20-23;6(1):137 (abstract no. Th.A.16). Unique Identifier : AIDSLINE ICA6/10001690; Peralta JM; Ferreira JA; Pieniazek D; Krebs JW; Sion FS; Ferrera Ramos Filho C; Morais de Sa CA; Weniger BG; Heyward WL; Ou CY; et al; Fundacao Oswaldo Cruz, Rio de Janeiro (RJ), Brazil; OBJECTIVE: Analysis of sera from Brazil in 1989 suggested the presence of HIV-1, -2, and mixed infections within the populace. To further evaluate these observations HIV-1 and -2 PCR analysis was performed on selected sero-reactive persons. METHODS: Peripheral blood mononuclear cel
Zidovudine therapy of asymptomatic HIV infected persons with less than 500 CD4+ cells/mm3 - ACTG protocol 019.: Int Conf AIDS. 1990 Jun 20-23;6(1):138 (abstract no. Th.B.17). Unique Identifier : AIDSLINE ICA6/10001790; Volberding P; Lagakos S; Koch M; Pettinelli C; Myers M; Booth D; University of California, San Francisco, California, USA; OBJECTIVES: Determine the safety and efficacy of zidovudine (ZDV) in asymptomatic HIV-infected subjects with CD4+ cell counts below 500/mm3. METHODS: Randomized trial of 1338 HIV-infected asymptomatic subjects with fewer than 500 CD4+ cells/mm3 comparing two dosages of ZDV (500 mg daily, 1500 mg daily in 5 doses) to p
Long term effects of zidovudine therapy in early HIV disease. Results from the Multicentre Canadian Azidothymidine Trial (MCAT).: Int Conf AIDS. 1990 Jun 20-23;6(1):138 (abstract no. Th.B.18). Unique Identifier : AIDSLINE ICA6/10001890; Ruedy J; Montaner JS; Schechter MT; Le T; Fanning M; Tsoukas C; Falutz J; Wells G; Child S; O'Shaughnessy M; et al; Canada; OBJECTIVE: To describe the long term effects of zidovudine (ZDV) therapy in early HIV infection. METHODS: Design: Multicentre, prospective, dose range finding study. Subjects: 74 HIV positive homosexual men (CDC groups IIB, III and IVC2; CD4 counts greater than 270). Intervention: Following a 3 weeks observation, volu
Functional status and well-being in a placebo-controlled trial of zidovudine in early ARC.: Int Conf AIDS. 1990 Jun 20-23;6(1):138 (abstract no. Th.B.19). Unique Identifier : AIDSLINE ICA6/10001990; Wu AW; Rubin HR; Mathews WC; Brysk LM; Hardy WD; Bozzette SA; Atkinson JH; Grant I; Richman DR; University of California, San Francisco, CA, USA; OBJECTIVE: To examine the impact of zidovudine (ZDV) on functional status and well-being in persons with early ARC. METHODS: Seventy-one subjects were randomized to ZDV 200 mg (n = 35) or placebo (n = 36) as part of ACTG Protocol 016. We measured health status at baseline, 1 month, and every 3 months thereafter. Our i
The efficacy and safety of a lower dose of zidovudine in the treatment of patients with AIDS-associated PCP.: Int Conf AIDS. 1990 Jun 20-23;6(1):138 (abstract no. Th.B.20). Unique Identifier : AIDSLINE ICA6/10002090; Fischl M; Parker CB; Pettinelli C; Wulfsohn M; Rasheed S; National Institute of Allergy and Infectious Diseases, Bethesda,; Maryland, USA; OBJECTIVES: To evaluate the efficacy and safety of a lower daily dose of zidovudine (ZVD) in the treatment of advanced HIV disease. METHODS: A randomized controlled trial was conducted in 524 subjects with a first episode of P. carinii pneumonia. 262 subjects received ZVD at an oral dose of 250 mg every 4 hrs (standar
Randomized prospective trial of two regimens of zidovudine (ZDV) in AIDS and ARC patients: 1200 mg/day vs 600 mg/day.: Int Conf AIDS. 1990 Jun 20-23;6(1):139 (abstract no. Th.B.21). Unique Identifier : AIDSLINE ICA6/10002190; Salmon D; Detruchis P; Matheron S; Bouvet E; Levacher M; Leport C; Hopital Claude Bernard - Bichat, Paris, France; OBJECTIVES: To compare tolerance and efficacy of two regimens of ZDV: full dose (FD) 200 mg every 4 hours and half dose (HD) 200 mg every 8 hours in AIDS and ARC patients (pts). METHODS: From 4/88 to 6/89, 76 pts were randomly assigned to receive either FD, or HD of ZDV. Inclusion criteria were Karnovsky index greater
A randomized trial comparing zidovudine, alpha interferon, or the combination in early HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):139 (abstract no. Th.B.22). Unique Identifier : AIDSLINE ICA6/10002290; Davey V; Cefali F; Metcalf JA; Masur H; Fauci AS; Lane HC; National Institutes of Health, Bethesda, Maryland, USA; OBJECTIVES: To compare tolerance and toxicity of administration of zidovudine (Z), alpha interferon (IFN), and the combination of both (Z + IFN) and to determine relative efficacy in delaying progression of HIV disease. METHODS: HIV-infected patients with greater than or equal to 500 CD4 cell/mm3, were randomized to o
Phase II trial of alternating and intermittent regimens of zidovudine (ZDV) and 2',3'-dideoxycytidine (ddC) in ARC and AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):139 (abstract no. Th.B.23). Unique Identifier : AIDSLINE ICA6/10002390; Skowron G; Merigan TC; Roger Williams General Hospital, Providence, RI, USA; OBJECTIVE: To determine the efficacy and toxicity of alternating and intermittent regimens of ZDV 200 mg q4h and low dose (0.01 mg/kg q4h) or high dose (0.03 mg/kg q4h) ddC compared with continuous ZDV alone in ARC and AIDS. METHODS: Patients were str
Decreased HIV plasma titer in response to combined low-dose zidovudine and acyclovir therapy in CDC class IVA patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):139 (abstract no. Th.B.24). Unique Identifier : AIDSLINE ICA6/10002490; Coombs RW; Collier AC; Chaloupka K; Corey L; University of Washington, Seattle, Washington, USA; OBJECTIVE: To measure the virologic response of low-dose zidovudine (300 versus 600 mg/day) with or without acyclovir (4800 mg/day) in CDC class IVA disease. METHODS: Twenty-two CDC class IVA patients enrolled in ACTG protocol 010 received zidovudine Q4H po at either 50mg (N=5)
Coping responses and psychological adjustment in gay men with AIDS: a longitudinal analysis.: Int Conf AIDS. 1990 Jun 20-23;6(1):140 (abstract no. Th.B.25). Unique Identifier : AIDSLINE ICA6/10002590; Reed GM; Kemeny ME; Taylor SE; University of Washington, Seattle, Washington, USA; OBJECTIVE: This study examined the relationship between coping responses of gay men diagnosed with AIDS and psychological adjustment, both cross-sectionally and longitudinally. METHODS: Fifty men with AIDS, recruited from the UCLA Multicenter AIDS Cohort Study (MACS), participated at Time 1. A subset of 24 men partici
Psychological adjustment to HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):140 (abstract no. Th.B.26). Unique Identifier : AIDSLINE ICA6/10002690; Kelly B; Raphael B; Zournazi A; Dunne M; Smith S; University of Queensland, Brisbane, Australia; OBJECTIVE: The preliminary phase of a multicentre prospective study of the correlates of psychiatric morbidity, psychological adjustment to disease and sexual behaviour in homosexual/bisexual HIV positive men is described. METHOD: To date 24 asymptomatic HIV+ (CDC II) homosexual/bisexual males have been recruited thro
Relationships between CD4 lymphocytes and psychosocial variables among HIV seropositive adults.: Int Conf AIDS. 1990 Jun 20-23;6(1):140 (abstract no. Th.B.27). Unique Identifier : AIDSLINE ICA6/10002790; Perry S; Jacobsberg L; Fishman B; Cornell University Medical College, NY, USA; OBJECTIVE: Determine if psychosocial factors correlate with total CD4, currently the best predictor of disease progression among HIV-infected individuals (HIV+). METHODS: Among 108 males and 8 females (CDC II/III), Pearson correlations were obtained between entry measures of total CD4 and standardized measures of psyc
Psychosocial adjustment to HIV infection: efficacy of different group interventions in gay and bisexual men.: Int Conf AIDS. 1990 Jun 20-23;6(1):140 (abstract no. Th.B.28). Unique Identifier : AIDSLINE ICA6/10002890; Earl W; Flinders R; Flahive M; Flinders T; Bartholow B; Kobayashi J; Cohn D; Denver Health and Hospitals, Denver, CO, USA; OBJECTIVE: To establish the level of distress experienced by HIV-infected gay and bisexual men and to assess the efficacy of psychosocial interventions in preventing maladaptive adjustment to living with HIV infection and AIDS. METHODS: Psychosocial inventories were administered to 4 groups of HIV-infected men: (1) pa
AIDS inpatients and psychiatric disturbances: diagnostical and therapeutical aspects.: Int Conf AIDS. 1990 Jun 20-23;6(1):141 (abstract no. Th.B.29). Unique Identifier : AIDSLINE ICA6/10002990; Tempesta E; Di Giannantonio M; Mattioni T; Persico AM; Lestingi L; Ortona L; Dept. of Psychiatry, Catholic University of S. Heart, Rome, Italy; A psychodiagnostical and psychopharmacotherapeutical study was conducted on a population of 40 IVDA and 10 homosexuals, affected by AIDS (CDC: 80% IV group) and hospitalized in the Infectious Diseases Ward. Hamilton Rating Scale for Anxiety (HRSA), Hamilton Rating Scale for Depression (HRDS) and Brief Psychiatric Rati
A comparison of self reported suicidal behaviors in different stages of HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):141 (abstract no. Th.B.30). Unique Identifier : AIDSLINE ICA6/10003090; Orr D; O'Dowd MA; McKegney FP; Natali C; Montefiore Medical Center, Albert Einstein College of Medicine,; Bronx, NY USA; OBJECTIVE: To examine the incidence of suicidal behaviors in patients at different stages of HIV infection. METHOD: 155 patients attending a psychiatric outpatient clinic for HIV related problems were surveyed regarding past and present suicidal behaviors. The population surveyed was predominantly Hispanic (54%) and 5
Pharmacologic management of delirium in medically hospitalized AIDS patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):141 (abstract no. Th.B.31). Unique Identifier : AIDSLINE ICA6/10003190; Marotta R; Breitbart W; Platt M; Corbera K; Weisman H; Cancellieri F; St. Luke's/Roosevelt Hospital Center, New York, New York, USA; OBJECTIVE: To compare the efficacy of three drug interventions in the treatment of delirium in medically hospitalized AIDS patients, i.e. Haloperidol (a high potency neuroleptic) vs. Chlorpromazine (a low potency neuroleptic), vs. Lorazepam (a benzodiazipene). METHODS: Patients admitted to two AIDS units were screened
The efficacy of imipramine in the treatment of HIV-related depression.: Int Conf AIDS. 1990 Jun 20-23;6(1):141 (abstract no. Th.B.32). Unique Identifier : AIDSLINE ICA6/10003290; Manning D; Jacobsberg L; Erhart S; Perry S; Frances A; Department of Psychiatry, The New York Hospital-Cornell Medical; Center, NY, USA; OBJECTIVE: To test the efficacy of antidepressant medication in the treatment of depressed HIV positive patients. Subsidiary objectives of this study are to determine how improvement in HIV related depression impacts on medical status and rate of progression of illness, suicide risk and other psychiatric morbidity, ov
Natural history of HIV infection in a cohort of homosexual and bisexual men: clinical and immunologic outcome, 1977-1990.: Int Conf AIDS. 1990 Jun 20-23;6(1):142 (abstract no. Th.C.33). Unique Identifier : AIDSLINE ICA6/10003390; Lifson AR; Hessol N; Rutherford G; O'Malley P; Barnhart L; Buchbinder S; Cannon L; Bodecker T; Holmberg S; Harrison J; et al; Dept. Public Health, San Francisco CA, USA; OBJECTIVE: To determine the relationship between duration of HIV infection and clinical and immunologic status in a cohort of homosexual and bisexual men. METHODS: From 1978 to 1980, we recruited 6,706 homosexual and bisexual men for studies of hepatitis B; men included in this analysis had well characterized dates of
Natural history of HIV infection, a prospective study in a cohort of 162 HIV seroconverters.: Int Conf AIDS. 1990 Jun 20-23;6(1):142 (abstract no. Th.C.34). Unique Identifier : AIDSLINE ICA6/10003490; Pedersen C; Gerstoft J; Lindhardt B:O; Lundgren JD; Jensen BL; Dickmeiss E; University of Copenhagen, Copenhagen, Denmark; OBJECTIVE: To examine the natural history of HIV infection, and to delineate factors of importance for disease progression. METHODS: 162 HIV seroconverters (less than 12 months between last seronegative and first seropositive sample) were followed for a median of 37 (range 1-131) months. All were healthy (CDC groups I
AIDS incidence trends over 5 years in the Multicenter AIDS Cohort Study (MACS).: Int Conf AIDS. 1990 Jun 20-23;6(1):142 (abstract no. Th.C.35). Unique Identifier : AIDSLINE ICA6/10003590; Visscher B; Munoz A; Jacobson L; Dudley JP; Chmiel J; Zhou S; Graham N; Vermund S; Detels R; UCLA Sch of Public Hlth, CA, USA; OBJECTIVE: To model the incidence of AIDS over calendar time in a cohort of infected men. METHODS: In 1984-85, 1809 HIV seropositive AIDS-free men were enrolled in the MACS. Data from 6 month visits and continuous reports of CDC-defined AIDS were used to determine the observed incidence by semester, starting in July,
Cessation of intravenous drug use reduces progression of HIV-infection in HIV+ drug users.: Int Conf AIDS. 1990 Jun 20-23;6(1):142 (abstract no. Th.C.36). Unique Identifier : AIDSLINE ICA6/10003690; Weber R; Ledergerber B; Opravil M; Luthy R; University of Zurich, Zurich, Switzerland; OBJECTIVE: To determine if cessation of drug use and methadone maintenance treatment programs reduce risk of progression of HIV infection in intravenous drug users (IVDU). METHODS: IVDU without antiretroviral therapy, categorized into 1. those remaining enrolled in a methadone program during observation period, 2. for
The rate of development of HIV-1 related illness in women with a known duration of infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):143 (abstract no. Th.C.37). Unique Identifier : AIDSLINE ICA6/10003790; Anzala A; Wambugu P; Bosire M; Ngugi EN; Waiyaki P; Plummer FA; University of Nairobi, Nairobi, Kenya; OBJECTIVE: To determine the rate and risk factors for the development of symptomatic HIV-1 related disease in women with a known duration of infection. METHODS: A cohort of 123 women working as prostitutes in Nairobi have been followed from the time of seroconversion to HIV-1. Women were evaluated at 3-6 month interva
The progression to AIDS in the Italian hemophilia population over a six-year period.: Int Conf AIDS. 1990 Jun 20-23;6(1):143 (abstract no. Th.C.38). Unique Identifier : AIDSLINE ICA6/10003890; Schinaia N; Chiarotti F; Istituto Superiore de Sanita, Rome, Italy; OBJECTIVE: To estimate the progression to AIDS in the Italian hemophilia population and to correlate the outcome with different clinical features. METHODS: Study subjects: all HIV-positive individuals already recruited at the on-going National Registry of Patients with Blood Clotting Disorders. Statistical analysis: t
Cigarette smoking and incidence of AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):143 (abstract no. Th.C.39). Unique Identifier : AIDSLINE ICA6/10003990; Royce RA; Winkelstein W; Bacchetti P; University of California, Berkeley, California, USA; OBJECTIVE: Investigate cigarette smoking as a cofactor for incidence of AIDS. METHODS: Smoking status and other covariates were determined at entry for members of the San Francisco Men s Health Study, a population based cohort of single men ages 25-54 observed biennially since 1984. Using the Cox proportional hazards
Survival in adults AIDS cases, Brazil, 1980-1989.: Int Conf AIDS. 1990 Jun 20-23;6(1):143 (abstract no. Th.C.40). Unique Identifier : AIDSLINE ICA6/10004090; Chequer P; Hearst N; Castilho E; Loures LA; Rodrigues L; Rutherford G; Division of DST/AIDS, Ministry of Health, Brasilia-Brasil; OBJECTIVE: To assess the extent to which the survival of adults AIDS cases in Brazil has been influenced by clinical and epidemiological features. METHODS: Using data from the Brazilian National AIDS registry, analyses were conducted to assess survival as a function of gender, risk
Routine vs. targeted prenatal testing for HIV.: Int Conf AIDS. 1990 Jun 20-23;6(1):144 (abstract no. Th.C.41). Unique Identifier : AIDSLINE ICA6/10004190; Barbacci M; Chaisson RE; Johns Hopkins University School of Medicine, Baltimore, Maryland,; USA; OBJECTIVE: To compare Centers for Disease Control (CDC) HIV screening guidelines to routine HIV screening of pregnant women. METHODS: Women attending the Johns Hopkins Obstetrics clinic between 2/87 and 8/88 who acknowledged risk factors for HIV infection were targeted for HIV screening, following recommended CDC scre
Perinatal outcome in HIV-infected women in Uganda.: Int Conf AIDS. 1990 Jun 20-23;6(1):144 (abstract no. Th.C.42). Unique Identifier : AIDSLINE ICA6/10004290; Guay L; Mmiro F; Ndugwa C; Kataha P; Mugisha K; Goldfarb J; Hom D; Friesen H; Toltzis P; Coulter B; et al; Case Western Reserve Univ., Cleveland, Ohio, USA; OBJECTIVE: To determine the effect of maternal HIV infection upon the course and outcome of pregnancy. METHODS: Women of unknown HIV-serological status were sequentially enrolled in the prenatal clinic at Mulago Hospital, Kampala. Maternal serological status was determined, and compared to the frequency of complicatio
Mother to child transmission of HIV: first immunologic and serologic features from an ongoing cohort study in Kigali, Rwanda.: Int Conf AIDS. 1990 Jun 20-23;6(1):144 (abstract no. Th.C.43). Unique Identifier : AIDSLINE ICA6/10004390; Van de Perre P; Simonon A; Hitimana DG; Msellati P; Dabis F; Baganizi E; Van Goethem C; Bazubagira A; Stevens AM; Lepage P; AIDS Reference Laboratory (National AIDS Control Program),; Kigali, Rwanda; OBJECTIVE: To evaluate immunologic and serologic parameters associated with Mother (M) to Child (C) transmission of HIV. METHODS: Two cohorts of 218 infants born of HIV seropositive (HIV +) M and 218 infants of HIV seronegative (HIV -) M were enrolled at delivery. A blood sample was available from the M and C at 0, 3,
Risk for HIV 1 perinatal transmission varies with the mother's stage of HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):144 (abstract no. Th.C.44). Unique Identifier : AIDSLINE ICA6/10004490; Boue F; Pons JC; Keros L; Chambrin V; Papiernik E; Henrion R; Delfraissy JF; Service de Medecine Interne et de Gynecologie-Hopital Antoine; Beclere-Clamart-92 141-France; OBJECTIVE: Recent European studies have shown an observed incidence of transmission of 30%. However, most of the women belong to CDC groups II and III and they are conflicting results concerning the relationship between mother s status and rate of perinatal transmission. METHODS: Between October 1985 and December 1989
Elevated maternal total and neutralizing anti-HIV1 antibody does not prevent perinatal HIV1.: Int Conf AIDS. 1990 Jun 20-23;6(1):145 (abstract no. Th.C.45). Unique Identifier : AIDSLINE ICA6/10004590; Krasinski K; Cao YZ; Friedman-Kien A; Borkowsky W; Fidelia A; Bebenroth D; NYU Med. Ctr., NY, NY, USA; OBJECTIVE: To determine if total and neutralizing anti-HIV1 maternal antibody protects children from HIV1 infection. METHODS: HIV1 infected mothers blood collected at delivery was titrated for: anti-HIV1 using EIA and neutralizing antibody. Neutralization was determined by 90% reduction of p24 antigen production in H
IgA specific antibody to HIV in infants.: Int Conf AIDS. 1990 Jun 20-23;6(1):145 (abstract no. Th.C.46). Unique Identifier : AIDSLINE ICA6/10004690; Martin N; Wara D; Levy J; Crombleholme W; Hourtane M; Legg H; Cowan M; Weintrub P; Dept. of Pediatrics, University of CA. San Fran., San Francisco,; CA 94143 USA; OBJECTIVE: The early serological diagnosis of HIV infection in infants and the determination of the sequence of development of antibodies to envelope and core proteins. METHODS: We developed an IgA Western Blot method using recombinant antigens (gp160, gp120, gp41, p25). Serum samples were obtained from 23 infants at
Lack of proviral sequences in children who have lost maternal antibody following birth to HIV (+) mothers.: Int Conf AIDS. 1990 Jun 20-23;6(1):145 (abstract no. Th.C.47). Unique Identifier : AIDSLINE ICA6/10004790; Rogers M; Ou C; Abrams E; Nesheim S; Mayers M; Conner E; Centers for Disease Control (CDC), Atlanta, GA. USA; OBJECTIVE: To determine whether children who have lost maternal antibody following birth to an HIV (+) mother are infected with HIV. METHODS: Children born to HIV (+) mothers are followed from birth at 4 sites. Those children who have lost maternal antibody were tested for proviral sequences by polymerase chain reacti
Transmission of HIV-infection from an infected infant to his mother by breast-feeding.: Int Conf AIDS. 1990 Jun 20-23;6(1):145 (abstract no. Th.C.48). Unique Identifier : AIDSLINE ICA6/10004890; Pokrovsky VV; Kuznetsova I; Eramova I; Central Research Institute of Epidemiology, 3-a,; Novogyreyevskaya, Moscow, USSR; During the existence of nosocomial focuses of HIV-infection in Elista, Rostov-on-Don, Volgograd there were 152 children and 12 mothers found to be seropositive. The children were infected due to using the same syringe on multiple patients. As far as the women were concerned, 2 of them had seropositive sexual partners,
Homosexually and nonhomosexually identified male blood donors who have sex with men: a behavioral comparison.: Int Conf AIDS. 1990 Jun 20-23;6(1):146 (abstract no. Th.D.49). Unique Identifier : AIDSLINE ICA6/10004990; Doll L; Centers for Disease Control, Atlanta, GA, USA; OBJECTIVE: Describe nonhomosexually identified men who have sex with men. METHODS: From June 1988-September 1989, 200 seropositive male blood donors who had sex with men were interviewed regarding HIV-related risk behaviors. Self-reported sexual identity was measured on a 7-pt. Kinsey scale. Perception of HIV risk was
AIDS-related health behavior and sexual practices of gay men in Japan.: Int Conf AIDS. 1990 Jun 20-23;6(1):146 (abstract no. Th.D.50). Unique Identifier : AIDSLINE ICA6/10005090; Sawazaki Y; Kehoe J; Department of Health Sociology, Graduate School of Medical; Science, University of Tokyo, Tokyo, Japan; OBJECTIVE: Though the majority of HIV patients in Japan are Haemophiliacs, the sexual transmission of HIV is increasing. To date, there has been no social research carried out on the sexual transmission of AIDS in Japan. This study looks specifically at Gay Men, exploring their know
Profile of the female prostitution in Mexico and HIV risk factors.: Int Conf AIDS. 1990 Jun 20-23;6(1):146 (abstract no. Th.D.51). Unique Identifier : AIDSLINE ICA6/10005190; Valdespino JL; Loo E; Izazola JA; Garcia ML; Magis C; Sepulveda J; General Directorate of Epidemiology, Ministry of Health, Mexico; OBJECTIVES: To analyze the socio-demographic profile, sexual practices, knowledge and attitudes on AIDS, condom use, and risk factors in female sex workers (FSW). METHODS: Results of KAB surveys and pilot studies are analyzed in a group of 3,612 FSW in 20 cities in Mexico ; studied
KAP-study and HIV-seroprevalence among prostitutes in rural Burkina Faso.: Int Conf AIDS. 1990 Jun 20-23;6(1):146 (abstract no. Th.D.52). Unique Identifier : AIDSLINE ICA6/10005290; Didier B; Lorenz N; Ouedraogo LH; Zina Y; Barth P; Rehle T; Ministere de la Sante et de l'Action Sociale, Ouagadougou,; Burkina Faso; OBJECTIVE: To obtain baseline data and to planify HIV education programs an HIV-seroprevalence-study combined with a KAP-Study were carried out among prostitutes working at a gold prospecting site in the North of Burkina Faso . METHODS: All 38 known prostitutes on the site were int
Psychosocial predictors of intended condom use among Zimbabwean schoolpupils.: Int Conf AIDS. 1990 Jun 20-23;6(1):147 (abstract no. Th.D.53). Unique Identifier : AIDSLINE ICA6/10005390; Wilson D; Lavelle S; University of Zimbabwe, Harare, Zimbabwe; OBJECTIVE: To identify psychosocial predictors of intended condom use among adolescents to develop optimally effective AIDS education approaches for this group. METHOD: Respondents were a purposive sample of 635 (388 male, 247 female) volunteers (mean age=18.2, SD=2.2) from urban and rural secondary schools in all Zim
Preferred strategies for safe sex: relation to past and actual behaviour among sexually active men and women.: Int Conf AIDS. 1990 Jun 20-23;6(1):147 (abstract no. Th.D.54). Unique Identifier : AIDSLINE ICA6/10005490; Gallois C; Kashima Y; Hills R; McCamish M; University of Queensland, St. Lucia (Brisbane), Queensland,; Australia; OBJECTIVES: To determine the preferred sexual strategies for reducing risk of HIV infection among sexually active heterosexual men and women and homosexual men. To compare these preferences to past behaviour, intentions and behaviour at the next sexual encounter, using recent revisions of the Theory of Reasoned Action
Serostatus and relationship formation in the gay community: the AIDS Behavioral Research Project.: Int Conf AIDS. 1990 Jun 20-23;6(1):147 (abstract no. Th.D.55). Unique Identifier : AIDSLINE ICA6/10005590; Hoff CC; McKusick L; Coates T; Hilliard B; Center for AIDS Prevention Studies, University of California, San; Francisco California USA; OBJECTIVE: As more gay men are tested for HIV antibody, it is becoming evident that serostatus will influence the nature of formation of primary partner bonds in this community. To investigate this question we compared tested seropositives, tested seronegatives, and those who did not know their serostatus or had not b
Sex and power: young women's sexuality in the shadow of AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):147 (abstract no. Th.D.56). Unique Identifier : AIDSLINE ICA6/10005690; Holland J; Ramazanoglu C; Scott S; Sharpe S; Thomson R; Institute of Education, London University, UK; This paper reports a qualitative investigation of the sexual practices, beliefs and understanding of young women, including their ideas and experience of risk, danger and control in sexual encounters. The implications of this information for the spread of HIV infection and sex and AIDS education are examined. We have
Access to clinical trials: the ACTU without walls concept.: Int Conf AIDS. 1990 Jun 20-23;6(1):148 (abstract no. Th.D.57). Unique Identifier : AIDSLINE ICA6/10005790; Kramer AS; Brownstein AP; The National Hemophilia Foundation, New York, NY USA; OBJECTIVE: To provide access to government-sponsored clinical trials for HIV-infected persons with hemophilia at the comprehensive hemophilia treatment centers (HTC) where approximately 50% of hemophilia patients in the U.S. receive care. METHOD: Of the 10 geographic regions (designated by the Department of Health and
Feasibility of early intervention, counseling and follow up of HIV positives in the Haitian community.: Int Conf AIDS. 1990 Jun 20-23;6(1):148 (abstract no. Th.D.58). Unique Identifier : AIDSLINE ICA6/10005890; Marcel AJ; Charles C; Pierre-Louis E; Romulus JR; Michel C; Landesman SH; SUNY Health Science Ctr./Kings County Hosp Ctr., Brooklyn, NY,; USA; OBJECTIVE: Are early intervention, adequate counseling and follow up feasible in a population reluctant to seek medical care? METHODS: From 4/88 to 12/89 50 persons (22M, 28F) testing HIV+ for immigration purposes were referred to a Haitian physician. All underwent counseling in Creole, a brief physical exam and lab e
Access, equity, and survival: use of ZVD and pentamidine by persons with AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):148 (abstract no. Th.D.59). Unique Identifier : AIDSLINE ICA6/10005990; Hidalgo J; Sugland B; Moore R; Chaisson RE; Department of Health and Mental Hygiene, AIDS Administration,; Baltimore, Maryland, USA; OBJECTIVE: Earlier studies have concluded that zidovudine (ZVD) and pentamidine produce significant increases in survival among PWAs. Despite the historically high cost and limited availability of ZVD and pentamidine, researchers have not adequately investigated the impact of access to these treatments on survival. Th
Medical care for intravenous drug users with AIDS and ARC: delivering services at a methadone treatment program.: Int Conf AIDS. 1990 Jun 20-23;6(1):148 (abstract no. Th.D.60). Unique Identifier : AIDSLINE ICA6/10006090; Batki SL; London J; Goosby E; Clement M; Wolfe R; Ryan C; French D; Young M; Miller D; Christmas R; et al; University of California, San Francisco, Department of; Psychiatry, San Francisco General Hospital, San Francisco, CA,; USA; OBJECTIVE: To examine the utilization of medical services provided for HIV-infected intravenous drug users (IVDUs) on-site at a methadone maintenance treatment (MMT) program. METHOD: On-site primary medical care was provided to serve 175 IVDUs in an MMT program at San Francisco General Hospital. Services were provided
A study of six home-care programmes for persons with HIV-infection in Africa.: Int Conf AIDS. 1990 Jun 20-23;6(1):149 (abstract no. Th.D.61). Unique Identifier : AIDSLINE ICA6/10006190; Westphal Victor B; Widdus R; Schietinger H; The Nordic School of Public Health, Goteborg, Sweden; OBJECTIVES: To analyze and compare selected home care programmes for persons with HIV-infection and their families in Africa; to discuss the programmes in the context of national AIDS policies and strategies and WHO s Health for All strategy and WHO policy documents; to suggest ways of learning from and sharing the kn
Insurance coverage for investigational drugs.: Int Conf AIDS. 1990 Jun 20-23;6(1):149 (abstract no. Th.D.62). Unique Identifier : AIDSLINE ICA6/10006290; Austein C; Walkover M; Hadley E; U.S. Department of Health and Human Services, Washington, D.C.,; USA; OBJECTIVE: To study the possibility of providing insurance coverage for investigational drugs to treat life-threatening diseases. METHODS: The study includes an analysis of the various types of investigational drugs available for patients with AIDS or other life-threatening illnesses. These include treatment INDs, gro
Buyers' clubs and the legitimization of the AIDS treatment underground -- the PWA (people with AIDS) Health Group as case study.: Int Conf AIDS. 1990 Jun 20-23;6(1):149 (abstract no. Th.D.63). Unique Identifier : AIDSLINE ICA6/10006390; Hodel D; Wilkinson SD; The PWA Health Group, New York, NY, USA; OBJECTIVE: To examine the history and development of the AIDS treatment substratum in the context of inferior treatment access systems in the United States . METHODS: The case history of the PWA Health Group (New York City) is documented and investigated in detail, via questionnaire, cl
Access to health care for HIV infection: a consumers perspective.: Int Conf AIDS. 1990 Jun 20-23;6(1):149 (abstract no. Th.D.64). Unique Identifier : AIDSLINE ICA6/10006490; Ludington P; American Association of Physicians for Human Rights, San; Francisco, CA, USA
HIV pathogenesis.: Int Conf AIDS. 1990 Jun 20-23;6(1):150 (abstract no. Th.A.65). Unique Identifier : AIDSLINE ICA6/10006590; Montagnier L; Institut Pasteur, Paris, France
Neutralising monoclonal antibody and rCD4 selected HIV-1 variants.: Int Conf AIDS. 1990 Jun 20-23;6(1):150 (abstract no. Th.A.66). Unique Identifier : AIDSLINE ICA6/10006690; McKeating JA; Clapham PR; Moore J; Ferguson M; Balfe P; Almond J; Evans; Weiss RA; Institute of Cancer Research, London, England; OBJECTIVE: Analysis of epitopes important for virus envelope-CD4 binding and antibody-mediated neutralisation. METHODS: Molecular cloned HIV was propagated in the presence of saturating levels of rCD4 or neutralising monoclonal antibodies (mab) specific for the epitopes on gp120 amino-acid (aa) residues 305-321, 430-4
HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure.: Int Conf AIDS. 1990 Jun 20-23;6(1):150 (abstract no. Th.A.67). Unique Identifier : AIDSLINE ICA6/10006790; Zack J; Arrigo S; Chen IS; University of California, Los Angeles, USA; OBJECTIVE: HIV-1 can infect quiescent human T-lymphocytes and remain in an inactive state until subsequent mitogenic stimulation of the cell. Studies were undertaken to identify the molecular nature of HIV-1 in quiescent primary lymphocytes. METHODS: Quiescent and dividing human peripheral blood lymphocytes were infec
Physical mapping of replicative and cytopathic properties of HIV-1.: Int Conf AIDS. 1990 Jun 20-23;6(1):150 (abstract no. Th.A.68). Unique Identifier : AIDSLINE ICA6/10006890; Cheng-Mayer C; Shioda T; Seto D; Levy JA; University of California, School of Medicine, San Francisco, USA; OBJECTIVE: To map viral genes that control in vitro biologic properties of HIV-1. METHODS: HIV-1 isolates (HIV-1SF2, HIVV-1SF13) obtained over-time from the same individual as he progressed from a relatively healthy state to disease were molecularly cloned. Biologically active recombinant viruses were generated betwee
Biological characterization of a highly cytopathic variant of an attenuated HIV-2.: Int Conf AIDS. 1990 Jun 20-23;6(1):151 (abstract no. Th.A.69). Unique Identifier : AIDSLINE ICA6/10006990; Hoxie JA; Haggarty B; Pletcher C; Sweet R; Chaikin M; Kappes JC; Hahn BH; Univ. of Penn, Philadelphia, PA, USA; OBJECTIVE: Naturally occurring and molecularly-derived isolates of HIV-2 have been described which are markedly attenuated in their ability to cause cytopathic effects in vitro, to downmodulate CD4 and to establish superinfection interference with cytopathic strains of HIV-1 and HIV-2. In order to determine the basis
Anti-HIV enhancing antibodies do not allow infection of a CD4-negative IgG Fc receptor-positive monocytic cell line.: Int Conf AIDS. 1990 Jun 20-23;6(1):151 (abstract no. Th.A.70). Unique Identifier : AIDSLINE ICA6/10007090; Grangette C; Ameisen JC; Maniez M; Tourvieille B; Antolin S; Vampouille N; Capron A; CIBP, Unite INSERM 167-CNRS 624, Institut Pasteur, Lille, France; OBJECTIVE: To investigate whether FcR-mediated antibody enhancement of HIV infection in the U937 monocytic cell line represents an additional mechanism of HIV infection that does not require CD4. METHODS: A CD4-negative IgG FcR-positive U937 cell line was derived from a CD4-positive IgG FcR-positive U937 cell line. Ab
Inhibition of HIV infection in vitro by anti-carbohydrate monoclonal antibodies.: Int Conf AIDS. 1990 Jun 20-23;6(1):151 (abstract no. Th.A.71). Unique Identifier : AIDSLINE ICA6/10007190; Hansen JE; Clausen H; Nielsen C; Teglbjaerg LS; Nielsen CM; Mathiesen L; Hakomori S; Nielsen JO; Dept. of Infectious Diseases, Hvidovre Hospital, Denmark; OBJECTIVE: To examine whether oligosaccharides of HIV could be targets for neutralizing antibodies in vitro. METHODS: Twenty anti-carbohydrate monoclonal antibodies (MAbs) were tested for their ability to inhibit in vitro HIV infection of peripheral blood mononuclear cells, and cell-lines MT4 (lymphocytic) and U937 (m
In vitro infection and generation of chronically HIV-1 infected CD3+CD8+ T cells from peripheral blood lymphocytes of healthy donors. Anti-CD2(2+3) mediated reactivation is associated with virus replication and cell death.: Int Conf AIDS. 1990 Jun 20-23;6(1):151 (abstract no. Th.A.72). Unique Identifier : AIDSLINE ICA6/10007290; DeMaria A; Pantaleo G; Schnittman SM; Fauci AS; NIAID, NIH, Bethesda, Maryland, USA; OBJECTIVE: To study infection status and virus replication in T-cell survivor populations of HIV-1 infected peripheral blood mononuclear cells (PBMC) after T-cell activation. METHODS: PBMC obtained from healthy HIV seronegative donors by Ficoll-Hypaque separation were cultured in the presence of PHA for 72 hours and s
Relationship between HIV-1 disease stage, titer of anti-P24 antibody (a-P24), and P24 antigen: a multicenter AIDS cohort study (MACS).: Int Conf AIDS. 1990 Jun 20-23;6(1):152 (abstract no. Th.A.73). Unique Identifier : AIDSLINE ICA6/10007390; Farzadegan H; Chmiel J; Saah A; Allain JP; Hardy W; Phair J; The Johns Hopkins University, Balitmore, MD, USA; OBJECTIVE: To investigate the serum levels of antigen/antibody for HIV-1 P24 viral component among HIV-1 infected/diseased homosexual men. METHOD: Anti-P24 Titration: A competitive ELISA using recombinant HIV-1 P24 antigen (Abbott Labs) was used and titers were expressed as the reciprocal of endpoint dilutions. P24 An
Antibody responses to selected peptides of HIV-1 gp160 in immunized or HIV-1 infected individuals.: Int Conf AIDS. 1990 Jun 20-23;6(1):152 (abstract no. Th.A.74). Unique Identifier : AIDSLINE ICA6/10007490; Buchanan T; Coombs R; Hu SL; Smith G; McCullough D; Jasman R; Corey L; University of Washington, Seattle, WA., USA; Peptides were synthesized to represent HIV-1 gp160: the V3 region (AA approximately 306-320, 14 sequence variant peptides) reactive with neutralizing and syncytium-inhibiting antibodies, the CD4 binding region (AA approximately 414-453, 30 peptides), and the immunodominant region (AA approximately 595-609, 2 peptides)
Production of human monoclonal antibodies against the V3 loop of gp120.: Int Conf AIDS. 1990 Jun 20-23;6(1):152 (abstract no. Th.A.75). Unique Identifier : AIDSLINE ICA6/10007590; Zolla-Pazner S; Gianakakos V; Williams C; Sharpe S; Gorny MK; Veterans Administration Medical Center, New York, New York, USA; OBJECTIVE: To generate human monoclonal antibodies (HumAb) against a neutralizing epitope of HIV-1 (MN) gp120. METHODS: Peripheral blood lymphocytes (PBL) were transformed by Epstein-Barr virus (EBV) as per PNAS, 86, 1624, 1989. Cultures were screened for antibody to a synthetic 24-mer peptide from the V3 region of MN
A neutralizing human monoclonal antibody (HMab) identifies an epitope within the putative CD4-binding domain (CD4-BD) of HIV-1 gp120.: Int Conf AIDS. 1990 Jun 20-23;6(1):152 (abstract no. Th.A.76). Unique Identifier : AIDSLINE ICA6/10007690; Ho DD; Li XL; Daar ES; Moudgil T; Sun NC; Holton D; Robinson JE; UCLA School of Medicine, Los Angeles, CA, USA; OBJECTIVE: To use HMabs to characterize epitopes of HIV-1 gp120 that are immunogenic during natural infection and are functionally important. METHODS: N70-1.5e is one of three IgG1 gp120-specific HMabs produced by EBV transformed cell lines derived from an HIV-1-infected patient. Antibody specificity was determined by
Development of an IgG-1 human monoclonal antibody that neutralizes HIV1 infectivity and binding and reacts with a cell surface antigen expressed by HIV1 infected cells.: Int Conf AIDS. 1990 Jun 20-23;6(1):153 (abstract no. Th.A.77). Unique Identifier : AIDSLINE ICA6/10007790; Posner M; Mukherjee M; Hideshima T; Cannon TC; Mayer K; Brown University Medical School, Providence, RI, USA; OBJECTIVE: Production of human monoclonal antibodies (HuMoAbs) reactive with HIV1 antigens to study and treat the disease caused by the virus. METHODS: Patient PBM transformed by Epstein Barr Virus (EBV) in oligoclonal cultures. Indirect immunofluorescence (IF) was used to screen for IgG antibodies reactive with HIV-I
Two immunodominant domains of the HIV-1 transmembrane glycoprotein, GP41, bind antibodies which enhance HIV-1 infection in vitro.: Int Conf AIDS. 1990 Jun 20-23;6(1):153 (abstract no. Th.A.78). Unique Identifier : AIDSLINE ICA6/10007890; Robinson WE Jr; Lake D; Gorny MK; Horton L; Montefiori DC; Zolla-Pazner S; Hersh E; Mitchell WM; Vanderbilt University, Nashville, TN, USA; OBJECTIVE: To identify and map human monoclonal antibodies to HIV-1 which enhance HIV-1 infection in vitro. METHODS: Human monoclonal antibodies (huMAb) were made by either fusion with a murine myeloma cell line P36x36 AgV1 or transformation of human PBMC with Epstein-Barr Virus. The ability of antibodies to enhance H
Identification of GP41 determinants recognized by antibodies in cytolytic assays.: Int Conf AIDS. 1990 Jun 20-23;6(1):153 (abstract no. Th.A.79). Unique Identifier : AIDSLINE ICA6/10007990; Wood L; Koenig S; Wood R; Fuerst T; Newell A; Brewah A; Fauci AS; NIH, NIAID, Bethesda, MD, USA; OBJECTIVE: To identify sequences within HIV-envelope recognized by antibody from HIV seropositive donors and to demonstrate lysis of target cells bearing these sequences by CD16+ cells from HIV seropositive donors. METHODS: MHC-mismatched lymphoblastoid cells (LCL) pulsed with synthesized peptides from gp41 were added
Biological properties of CD4 immunoadhesins.: Int Conf AIDS. 1990 Jun 20-23;6(1):153 (abstract no. Th.A.80). Unique Identifier : AIDSLINE ICA6/10008090; Capon DJ; Byrn RA; Mordenti J; Smith D; Lucas C; Marsters SA; Chamow SM; Wurm FM; Gregory T; Groopman JE; Genentech, Inc., 460 Point San Bruno Boulevard, South San; Francisco, California 94080, USA; Molecular fusions of CD4, the receptor for HIV, with immunoglobulin (termed CD4 immunoadhesins) possess both the gp120-binding and HIV-blocking properties of recombinant soluble CD4 (rCD4) and certain properties of IgG, notably long plasma half-life and Fc receptor binding. We show that a CD4 immunoadhesin can mediate
Clinical studies with ddI.: Int Conf AIDS. 1990 Jun 20-23;6(1):154 (abstract no. Th.B.81). Unique Identifier : AIDSLINE ICA6/10008190; Dolin R; Infectious Disease Unit, University of Rochester Medical Center,; Rochester, NY, USA
Clinical studies with ddC.: Int Conf AIDS. 1990 Jun 20-23;6(1):154 (abstract no. Th.B.82). Unique Identifier : AIDSLINE ICA6/10008290; Merigan T; School of Medicine, Stanford University Medical Center, Stanford,; CA, USA
Anti-retroviral drugs as single agents and in combination therapy.: Int Conf AIDS. 1990 Jun 20-23;6(1):154 (abstract no. Th.B.83). Unique Identifier : AIDSLINE ICA6/10008390; Yarchoan R; National Cancer Institute, National Institutes of Health,; Bethesda, MD, USA
Recombinant soluable CD4 and derivatives.: Int Conf AIDS. 1990 Jun 20-23;6(1):154 (abstract no. Th.B.84). Unique Identifier : AIDSLINE ICA6/10008490; Corey L; University of Washington, Seattle, WA, USA
Interferons.: Int Conf AIDS. 1990 Jun 20-23;6(1):155 (abstract no. Th.B.85). Unique Identifier : AIDSLINE ICA6/10008590; Lane HC; Laboratory of Immuno regulation, National Institutes of Health,; Bethesda, MD, USA
Immune based therapies for HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):155 (abstract no. Th.B.86). Unique Identifier : AIDSLINE ICA6/10008690; Schooley R; Massachusetts General Hospital, Boston, MA, USA
Significance and management of immune thrombocytopenia in HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):156 (abstract no. Th.B.89). Unique Identifier : AIDSLINE ICA6/10008990; Oksenhendler E; Department of Clinical Immunology and Hematology, Hopital; Saint-Louis, Paris, France
Use of hemapoeotic growth factors.: Int Conf AIDS. 1990 Jun 20-23;6(1):156 (abstract no. Th.B.90). Unique Identifier : AIDSLINE ICA6/10009090; Mitsuyasu R; UCLA Medical Center, Los Angeles, CA, USA
Kaposi's sarcoma as a sexually transmitted disease.: Int Conf AIDS. 1990 Jun 20-23;6(1):156 (abstract no. Th.B.91). Unique Identifier : AIDSLINE ICA6/10009190; Peterman T; Centers for Disease Controls, Atlanta, GA, USA
Presentation and management of Kaposi's sarcoma in Central Africa.: Int Conf AIDS. 1990 Jun 20-23;6(1):156 (abstract no. Th.B.92). Unique Identifier : AIDSLINE ICA6/10009290; Bayley AC; University of Zambia, Lusaka, Zambia
New directions in the treatment of HIV-related non-Hodgkin's lymphoma.: Int Conf AIDS. 1990 Jun 20-23;6(1):157 (abstract no. Th.B.93). Unique Identifier : AIDSLINE ICA6/10009390; Kaplan LD; San Francisco General Hospital, University of California, San; Francisco, CA, USA
Premalignant and malignant lesions associated with human papillomavirus infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):157 (abstract no. Th.B.94). Unique Identifier : AIDSLINE ICA6/10009490; Palefsky J; University of California, San Francisco, CA, USA
Non ulcerative sexually transmitted diseases (STD) as risk factors for HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):158 (abstract no. Th.C.97). Unique Identifier : AIDSLINE ICA6/10009790; Laga M; Nzila N; Manoka AT; Malele M; Bush TJ; Behets F; Heyward WL; Piot P; Ryder R; CDC, Atlanta, GA, USA; OBJECTIVES: To identify risk factors associated with HIV infection among prostitutes in Kinshasa, Zaire . METHODS: Among 493 HIV (-) prostitutes followed prospectively for a mean duration of 11 months (with monthly STD checkups and HIV testing every 3 months), a case control study
Risk factors for HIV-1 infection in pregnant women in Malawi.: Int Conf AIDS. 1990 Jun 20-23;6(1):158 (abstract no. Th.C.98). Unique Identifier : AIDSLINE ICA6/10009890; Chiphangwi J; Dallabetta G; Saah A; Liomba G; Miotti P; Ministry of Health, Malawi; OBJECTIVE: To assess the prevalence and associated risk factors for HIV-1 infection in pregnant women attending an antenatal clinic. METHODS: 1482 pregnant women presenting for routine care to the antenatal clinic of a large urban hospital in Malawi were interviewed to assess risk
Contraceptive use and HIV infection among women attending family planning clinics in Nairobi, Kenya.: Int Conf AIDS. 1990 Jun 20-23;6(1):158 (abstract no. Th.C.99). Unique Identifier : AIDSLINE ICA6/10009990; Mati J; Maggwa A; Chewe D; Solomon M; Mbugua S; Bhullar V; Tukei P; Hunter D; Achola P; University of Nairobi, Kenya; OBJECTIVES: To investigate the relationship between HIV infection and contraceptive use among women not believed to be at high risk for HIV. METHODS: Between Oct. 1989 and Jan. 1990, consenting women attending two Nairobi family planning (FP) clinics were screened for HIV and other sexually transmitted diseases (STD),
Heterosexual transmission of HIV: follow-up of a European cohort of couples.: Int Conf AIDS. 1990 Jun 20-23;6(1):158 (abstract no. Th.C.100). Unique Identifier : AIDSLINE ICA6/10010090; De Vincenzi I; Ancelle-Park R; WHO Collaborating Centre on AIDS, Paris, France; OBJECTIVE: To assess acceptability and evaluate efficacy of safe-sex counselling in serologically discordant couples. METHODS: Since March 1987, 403 couples were recruited from 7 European countries. Data for HIV+ subjects (Index Case) and their heterosexual partners are collected every 6 months and counselling was off
The relative efficiency of female-to-male HIV sexual transmission.: Int Conf AIDS. 1990 Jun 20-23;6(1):159 (abstract no. Th.C.101). Unique Identifier : AIDSLINE ICA6/10010190; Padian N; Shiboski S; Jewell N; University of California, San Francisco, California, USA; OBJECTIVE: To examine the relative efficiency of female-to-male heterosexual transmission of HIV among couples in San Francisco. METHODS: We enrolled 41 male sexual partners of 38 HIV-infected women in 1985-1989. HIV serological tests and detailed risk factor interviews were administered to both partners. Transmission
HIV recovery from semen: minimal impact of clinical stage of infection and minimal effect on semen analysis parameters.: Int Conf AIDS. 1990 Jun 20-23;6(1):159 (abstract no. Th.C.102). Unique Identifier : AIDSLINE ICA6/10010290; Krieger J; Coombs R; Collier A; Ross S; Chaloupka K; Cummings D; Corey L; University of Washington School of Medicine, Seattle, WA, USA; OBJECTIVE: We investigated the role of stage of infection on presence of culturable HIV in semen. METHODS: Specimens from 18 asymptomatic patients and 18 patients with AIDS were separated into seminal cells and plasma, then co-cultured with phytohemagglutinin-stimulated lymphocytes. RESULTS: HIV was isolated from peri
Crack use predicts incident HIV seroconversion.: Int Conf AIDS. 1990 Jun 20-23;6(1):159 (abstract no. Th.C.103). Unique Identifier : AIDSLINE ICA6/10010390; Schoenbaum EE; Hartel D; Friedland GH; Montefiore Medical Center, Bronx, New York City, NY, USA; OBJECTIVE: To examine the relation of CRACK use to HIV risk factors and HIV seroconversion among seropositive (SP) and seronegative (SN) intravenous drug users (IVDUs) in New York City. METHODS: From 6/85 - 12/88 576 methadone maintained IVDUs enrolled in a prospective study of HIV infection had serial interviews rega
Nosocomial transmission of HIV in Romania.: Int Conf AIDS. 1990 Jun 20-23;6(1):159 (abstract no. Th.C.104). Unique Identifier : AIDSLINE ICA6/10010490; Beldescu N; Apetrei R; Calumfirescu A; National AIDS Committee, Ministry of Health, Bucharest, Romania; OBJECTIVE: To determine the risk factors and geographic spread of HIV infection among children in Romania . METHODS: Collection of serum for HIV testing from representative samples of children under 7 years of age with history of recent hospitalization, collection of serum from mot
Distribution and determinants for risk behaviors of HIV infection among young adults in Zaire, a KAP study.: Int Conf AIDS. 1990 Jun 20-23;6(1):160 (abstract no. Th.C.105). Unique Identifier : AIDSLINE ICA6/10010590; Moore M; Bomboko B; Bertrand WE; Adjou Moumouni; Kashala TD; Centers for Disease Control, Atlanta, GA, USA; OBJECTIVE: The purpose of the study was to determine the distribution and the determinants for risks behaviors of HIV infection among young adults in Zaire . METHODS: A self-administered questionnaire was given to randomly selected College students in Kinshasa. The selection was me
HIV transmission knowledge, beliefs about personal risk of AIDS and condom use in the U.S., France, and U.K.: Int Conf AIDS. 1990 Jun 20-23;6(1):160 (abstract no. Th.C.106). Unique Identifier : AIDSLINE ICA6/10010690; Wells JA; Will A; Sell R; Valleron AJ; Cohen M; DeFilippes P; Project HOPE Center for Health Affairs, Chevy Chase, Maryland,; USA; OBJECTIVE: To compare patterns and levels of transmission knowledge and beliefs about AIDS risk in three countries and compare associations of knowledge and belief with condom use during vaginal intercourse, anal intercourse among men, and initiation of condom use. METHODS: Interviews with national probability samples
HIV-1 behavioral and sociological risks and condom use in gay men in Mexico.: Int Conf AIDS. 1990 Jun 20-23;6(1):160 (abstract no. Th.C.107). Unique Identifier : AIDSLINE ICA6/10010790; Izazola JA; Valdespino JL; Sepulveda J; Gortmaker SL; Townsend J; Palacios M; Mueller N; Becker J; Ministry of Health, Mexico; OBJECTIVE: To estimate behavioral and sociological risk factors for HIV seropositivity and condom use in gay and bisexual men in Mexico . METHODS: Data about knowledge, attitudes and practices (KAP) about AIDS were collected for 715 men; interviews took place in gay gathering places
Relapse from safer sex: the AIDS behavioral research project.: Int Conf AIDS. 1990 Jun 20-23;6(1):160 (abstract no. Th.C.108). Unique Identifier : AIDSLINE ICA6/10010890; Stall R; Ekstrand M; Pollack L; Coates TJ; UC-SF Center for AIDS Prevention Studies, (CAPS), San Francisco,; CA, USA; OBJECTIVE: To determine the extent and correlates of relapse from safe sex. METHODS: This reports data from a 5-year prospective study of gay men in San Francisco. In the 1988 wave of data collection, 71% (n=575) of the original cohort continued to respond to the survey. Independent variables included psychosocial mea
Recent changes in behaviour and practices in relation to the HIV epidemic in Rakai, Uganda.: Int Conf AIDS. 1990 Jun 20-23;6(1):161 (abstract no. Th.C.109). Unique Identifier : AIDSLINE ICA6/10010990; Musagara M; Konde-Lule J; Mugrave S; Serwadda D; Wawer MJ; Sewankambo N; AIDS Control Programme/Rakai Project, Uganda; OBJECTIVE: To define changes in behaviour and practices made in response to knowledge of the HIV epidemic. METHODS: 21 clusters of 40 households each were randomly selected, (9 trading center clusters and 12 rural). All consenting adults answered a Knowledge, Attitudes and Behaviours (KAB) interview (n=1304). In addit
Condom use and sexually transmitted diseases (STDs) among commercial sex workers (CSWs) undergoing a health education (HE)/intervention program on AIDS in the Philippines.: Int Conf AIDS. 1990 Jun 20-23;6(1):161 (abstract no. Th.C.110). Unique Identifier : AIDSLINE ICA6/10011090; Monzon OT; Santana RT; Paladin FJ; Bautista AN; Bagasao TM; Giannone P; Department of Health Research Institute for Tropical Medicine,; Metro Manila, Philippines; OBJECTIVES: 1) To obtain baseline information on prevalence of HIV and other STDs among CSWs. 2) To correlate condom use and STD prevalence. METHODS: Baseline information on STD prevalence and condom use were obtained on a cohort of 680 female CSWs prior to initiation of an ongoing 2-year HE/intervention program on AI
Incidence of heterosexual pairings associated with risk of secondary HIV transmission: population-based estimates.: Int Conf AIDS. 1990 Jun 20-23;6(1):161 (abstract no. Th.C.111). Unique Identifier : AIDSLINE ICA6/10011190; Capell FJ; Schiller G; California Department of Health Services, Sacramento, California,; USA; OBJECTIVE: To assess the potential in California (CA) for sexual transmission of HIV from intravenous drug users (IVDU) and male bisexuals (MB) to segments of the heterosexual population with no other risks for infection. METHODS: We used probability sample telephone survey methods to select and interview 6,673 CA adu
Heterogeneity and fluctuations in homosexual behavior: implications for modeling the AIDS epidemic.: Int Conf AIDS. 1990 Jun 20-23;6(1):161 (abstract no. Th.C.112). Unique Identifier : AIDSLINE ICA6/10011290; Van Griensven G; De Vroome E; Veugelers P; Coutinho RA; Municipal Health Service, Amsterdam, The Netherlands; OBJECTIVE: Heterogeneity in mathematical models is mostly restricted to variation in sexual partner change. Less attention is paid to variation in sexual role behavior. We assume the existence of 4 sexual subgroups based on the preference for: 1) no anal intercourse; 2) anal insertive only; 3) anal receptive only; 4)
The UK declaration of the rights of people with HIV and AIDS: voluntary organisations join to defend human rights.: Int Conf AIDS. 1990 Jun 20-23;6(1):162 (abstract no. Th.D.113). Unique Identifier : AIDSLINE ICA6/10011390; Grimshaw J; Jay M; Kelmanson A; National AIDS Trust (NAT), London, England; OBJECTIVE: A group of voluntary organisations concerned with AIDS and HIV is seeking to raise awareness of the human rights dimensions of the treatment of people with AIDS and HIV in the UK and internationally. METHODS: A working group, convened by the NAT, established a list of shared concerns which have been related
AIDS and human rights in Czechoslovakia.: Int Conf AIDS. 1990 Jun 20-23;6(1):162 (abstract no. Th.D.114). Unique Identifier : AIDSLINE ICA6/10011490; Machala L; Infections House, Bulovka Hospital, Prague, Czechoslovakia
AIDS, human rights and discrimination in Mexico.: Int Conf AIDS. 1990 Jun 20-23;6(1):162 (abstract no. Th.D.115). Unique Identifier : AIDSLINE ICA6/10011590; Galvan F; de la Pena R; Gonzalez R; Universidad Autonoma Metropolitana, GIS-SIDA, AC, Mexico; OBJECTIVE: To describe what kind of human rights are frequently violated in AIDS related conditions. Explain the function of sociopolitical, legal and cultural factors in shaping such aggravating. METHODOLOGY: In-depth interviewing, opinion polls in-live research, documentary testimonial and subject analysis. RESULTS:
HIV seropositivity in Spanish prisons.: Int Conf AIDS. 1990 Jun 20-23;6(1):162 (abstract no. Th.D.116). Unique Identifier : AIDSLINE ICA6/10011690; Granados A; Miranda MJ; Martin L; Ministerio Justicia, Madrid, Espana; OBJECTIVE: is to know the prevalence of HIV, hepatitis B and syphilis infection among the Spanish prison population, so as the risk factors which do determine it. In order to administer preventive or curative treatment. METHODOLOGY: A transversal study has been performed all over the Spanish prison population, in Marc
Issues in AIDS related legislation: health control versus human rights.: Int Conf AIDS. 1990 Jun 20-23;6(1):163 (abstract no. Th.D.117). Unique Identifier : AIDSLINE ICA6/10011790; Bhimani GV; Gilada IS; Thakur V; Indian Health Organisation, J.J. Hospital, Bombay, India; OBJECTIVE: Legislation is likely to be the most conflictual area of sociopolitical response to AIDS. The need for international consensus was highlighted by the experience of a case study. METHOD: As a test case we were involved in countermanding a legislation in one of the states in In
The impact of HIV infection on homophobia in the U.S.: Int Conf AIDS. 1990 Jun 20-23;6(1):163 (abstract no. Th.D.118). Unique Identifier : AIDSLINE ICA6/10011890; Coles M; ACLU--San Francisco, CA, USA
Poor sustainability of birth control utilization and consequent high fertility rates in a cohort of 249 HIV(+) Zairian women aware of their serostatus and followed for 30 months post-partum.: Int Conf AIDS. 1990 Jun 20-23;6(1):164 (abstract no. Th.D.121). Unique Identifier : AIDSLINE ICA6/10012190; Badi N; Nsuami M; Mundele L; Utshudi M; Matela B; Ryder R; Projet SIDA, Kinshasa, Zaire; OBJECTIVE: To measure the use and effect on fertility rates (FR) of BC techniques freely provided to a cohort of HIV(+) and HIV(-) mothers informed of their HIV serostatus during the immediate post-partum period. METHODS: 249 HIV(+) and 310 age-matched HIV(-) women were enrolled shortly before delivery in 1986-87. Fol
Community impact of maternal HIV-1 infections on infant and childhood survival in a Haitian slum 1976-1989.: Int Conf AIDS. 1990 Jun 20-23;6(1):164 (abstract no. Th.D.122). Unique Identifier : AIDSLINE ICA6/10012290; Boulos R; Halsey N; Coberly J; Holt E; Kissinger P; Brutus JR; Quinn T; Ruff A; Boulos C; The Centers for Development and Health, Port-au-Prince, Haiti; OBJECTIVE: To evaluate trends in seroprevalence of HIV-1 in pregnant women and the community impact of maternal HIV infection on survival of children. METHODS: From 1986-1989 women attending prenatal clinics in Cite Soleil were screened for antibodies to HIV-1. Infant mortality was estimated by conducting fertility an
Treating the non-infected sibling: an AIDS dilemma.: Int Conf AIDS. 1990 Jun 20-23;6(1):164 (abstract no. Th.D.123). Unique Identifier : AIDSLINE ICA6/10012390; Harris A; Nozyce M; Caffrey B; Wiznia A; Caspe W; Bronx-Lebanon Hospital Center, Albert Einstein College of; Medicine, Bronx, New York, USA; OBJECTIVE: To assess the entire family dynamics and to offer individualized services to the non-infected siblings. METHODS: The clinic is currently following 90 children: 29 are in foster care, 20 with relatives and 31 are living with their biological mothers. Seven families have relocated and three have been lost to
Adult children of persons with AIDS: issues and treatment.: Int Conf AIDS. 1990 Jun 20-23;6(1):164 (abstract no. Th.D.124). Unique Identifier : AIDSLINE ICA6/10012490; Greene D; McVinney D; Gay Men's Health Crisis, New York, New York, USA; OBJECTIVE: The objective of this paper is to: 1) identify psychological themes and behaviors expressed by adult children of Persons With AIDS (PWA s) and 2) to identify counseling strategies specific to this population. METHOD: Information presented will be based upon descriptive data collected through five years of c
Clinicians' attitudes about the aggressiveness of treatment for newborns at risk for AIDS: an ethical issue in the NICU.: Int Conf AIDS. 1990 Jun 20-23;6(1):165 (abstract no. Th.D.125). Unique Identifier : AIDSLINE ICA6/10012590; Levin BW; Driscoll JM; Fleischman AR; Brooklyn College, Brooklyn, NY, USA; OBJECTIVE: To investigate attitudes about treatment for newborns in neonatal intensive care units (NICUs) who are at risk for AIDS. METHODS: Questionnaires were distributed to physicians, nurses, and ethics committee members in NICUs at six hospitals in New York City; 247 responded. Treatment recommendations were elic
Pediatric AIDS hospitalizations in New Jersey.: Int Conf AIDS. 1990 Jun 20-23;6(1):165 (abstract no. Th.D.126). Unique Identifier : AIDSLINE ICA6/10012690; Conviser R; Grant C; Coye M; Children's Hospital AIDS Program, Newark, NJ, USA; OBJECTIVE: To determine correlates of inpatient utilization for all children with AIDS hospitalized in New Jersey during 1987. METHODS: All New Jersey hospital discharge abstracts from 1987 were scanned for AIDS diagnoses and matched to the state AIDS Registry to find those corresponding to children under 13 with AIDS
AIDS orphans in Kinshasa, Zaire.: Int Conf AIDS. 1990 Jun 20-23;6(1):165 (abstract no. Th.D.127). Unique Identifier : AIDSLINE ICA6/10012790; Kamenga M; DaSilva M; Muniaka K; Matela B; Batter V; Ryder R; Projet SIDA, Kinshasa, Zaire; OBJECTIVES: To determine the impact premature maternal mortality has had on children whose mothers have died of HIV/AIDS (AIDS orphans). METHODS: Since 1986 475 newborn infants of 466 HIV(+) women and 616 newborn infants of 606 matched HIV(-) women have been followed. Within this cohort, a nested case-control study ha
Adoption as a life plan for HIV-positive children.: Int Conf AIDS. 1990 Jun 20-23;6(1):165 (abstract no. Th.D.128). Unique Identifier : AIDSLINE ICA6/10012890; Gurdin P; Wiznia A; Canepa L; Leake and Watts Children's Home Inc., Yonkers, NY, USA; OBJECTIVE: To demonstrate that, by means of innovative recruitment and supportive services strategies, families can be identified which will adopt HIV-positive children. METHODS: A historical data base describing the HIV-positive children placed with foster families by Leake and Watts pioneering AIDS specialized fost
Nutritional status of HIV+ patients during the early stages of disease.: Int Conf AIDS. 1990 Jun 20-23;6(1):168 (abstract no. Th.B.200). Unique Identifier : AIDSLINE ICA6/10020090; Coulston A; McCorkindale C; Dybevik K; Merigan T; Stanford University, Stanford, CA, USA; OBJECTIVE: To improve our understanding of the malnutrition of AIDS patients, monthly nutritional assessment (NA) has been determined on HIV+ patients early in the disease. METHODS: Twenty-six HIV+ men from ACTU studies were recruited. Group I had 19 men (13 CDC Group II and 6 CDC Group IVA) and were followed for 16 m
Dietary intake in AIDS, AIDS-related complex and asymptomatic seropositive HIV patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):168 (abstract no. Th.B.201). Unique Identifier : AIDSLINE ICA6/10020190; Seaton T; Dworkin B; Wormser G; New York Medical College, Valhalla, New York, USA; A major manifestation of AIDS is the development of cachexia. This likely results from a multifactorial interplay of poor diet, malabsorption and altered metabolism. To assess the role of nutrient intake, we performed an analysis of a 72 hour diet record in clinically stable patients with AIDS (N=18), ARC (N=12) and a
Dietary intake, nutritional status, and immunologic function in patients with HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):168 (abstract no. Th.B.202). Unique Identifier : AIDSLINE ICA6/10020290; Chlebowski R; Grosvenor M; Kruger S; Tai V; Beall G; Harbor-UCLA Medical Center, Department of Medicine, Torrance, CA,; USA; Nutritional status is a major determinant of HIV survival (Am J Gastro 84:1288, 1989). To investigate etiologic factors, relationships among dietary intake, nutritional status, and immunologic function were determined using food records obtained for 537 patient days at 89 intervals from 55 favorable performance status
Evaluation and therapy of malnutrition in enteropathogenic AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):168 (abstract no. Th.B.203). Unique Identifier : AIDSLINE ICA6/10020390; Scevola D; Barbarini G; Zambelli A; Bottari G; Guanziroli A; Franchini A; Inst. Infect. Dis., University of Pavia, IRCCS Policlinico S.; Matteo, Pavia, Italy; OBJECTIVE: The high frequency of gastrointestinal pathology depicts so called enteropathogenic AIDS in which malnutrition may influence the course of disease. This study defines microbiological, biochemical, immunological and anthropometric aspects of malnutrition that require nutritional therapy. METHODS: Actual and
Increased energy expenditure and lean body mass in HIV infected patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):169 (abstract no. Th.B.204). Unique Identifier : AIDSLINE ICA6/10020490; Melchior JD; Salmon D; Rigaud D; Leport C; Vilde JL; Apfelbaum M; Hopital Bichat - Claude Bernard, Paris, France; OBJECTIVE: Is body weight loss in stable HIV-infected patients caused by increased Resting Energy Expenditure (REE)? METHODS: REE was measured by indirect calorimetry in 29 malnourished HIV patients: 9 ARC, 20 AIDS (28 men, 1 woman). Patients with fever or uncontrolled opportunistic infections were excluded. Lean Body
Hypovitaminemia B-12 in HIV infected patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):169 (abstract no. Th.B.205). Unique Identifier : AIDSLINE ICA6/10020590; Riera A; Remacha A; Cadafalch J; Gimferrer E; Serveis de Medicina Interna i Hematologia. Seccio Patologia; Organica. Unitat Toxicomanies. Programa Sant Pau-CITRAN.; Hospital de la Santa Creu i Sant Pau. UAB. Barcelona. Spain.; It has been reported that some HIV infected patients have low vitamin B-12 (B-12) levels. OBJECTIVE: To assess the changes in B-12 and folic acid status in HIV infected patients. MATERIAL AND METHODS: We have studied 60 HIV infected patients, admitted in the Internal Medicine Department during a period of 4 months. 44
Trace metal and vitamin deficiencies in AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):169 (abstract no. Th.B.206). Unique Identifier : AIDSLINE ICA6/10020690; Malcolm JA; Tynan PF; Sutherland DC; Dobson P; Kelson K; Carlton J; Department of Clinical Immunology, Royal Newcastle Hospital,; Newcastle, Australia; OBJECTIVE: To examine the prevalence and significance of trace metal and vitamin deficiencies in AIDS. METHODS: Twenty nine patients were studied, 6 with ARC and 23 with AIDS. Mean age was 36 years (SD=12.0, range 21 to 69 years). Vitamin and trace metal levels and a range of other biochemical variables were examined.
Lipid abnormalities in HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):169 (abstract no. Th.B.207). Unique Identifier : AIDSLINE ICA6/10020790; Blatt S; Zajac R; Lucey D; Hendrix C; Abbadessa S; Melcher G; Boswell R; Wilford Hall USAF Medical Center, Lackland Air Force Base, Texas,; USA; OBJECTIVE: AIDS is characterized by a chronic wasting process resulting in severe cachexia. Non-HIV related cachexia is associated with serum hypertriglyceridemia and variable decreases in serum cholesterol. Animal models suggest these lipid abnormalities are mediated by Tumor Necrosis Factor (TNF) alpha. To understan
Three month evaluation of a controlled high calorie/protein intake in AIDS patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):170 (abstract no. Th.B.208). Unique Identifier : AIDSLINE ICA6/10020890; Johnston S; Clotet B; Biosca C; Abad E; Alcalde C; Castro T; Pont M; Dietetic Dept. Hospital Germans Trias i Pujol - Badalona -; Barcelona - Spain; OBJECTIVE: Since malnutrition is widespread in AIDS patients, this study aimed to evaluate the efficacy of a high calorie/protein intake in HIV seropositive patients with 5-10% weight loss and poor appetite over a 3 month period. METHOD: We introduced 23 male patients fulfilling the AIDS criteria with a mean age of 31
Metabolic disturbances in AIDS: the role of circulating interferon alpha (IFNa) and tumor necrosis factor (TNF) in the hypertriglyceridemia of AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):170 (abstract no. Th.B.209). Unique Identifier : AIDSLINE ICA6/10020990; Grunfeld C; Pang MY; Doerrler W; Shigenaga JK; Kotler DP; Feingold KR; University of California, San Francisco, CA, USA; AIDS is characterized by increased serum triglycerides (TG), elevated circulating levels of cytokines and depletion of body cell mass (wasting). It is thought that cytokines mediate the metabolic disturbances of infection. We measured triglyceride and cytokine levels, triglyceride clearance and lean body mass in patie
Evaluation of the effectiveness of megestrol acetate as inducer of appetite, weight gain and improved nutrition in ARC patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):170 (abstract no. Th.B.210). Unique Identifier : AIDSLINE ICA6/10021090; Viteri FE; Kahn J; Mudie H; Conroy A; Abrams D; Hellerstein M; University of California, Berkeley, CA, USA; OBJECTIVE: To determine the changes in nutritional, immunological and clinical status induced by an 8 week course of 800 mg/day Megestrol Acetate (MA) in ARC patients with weight loss greater than 5% whether or not patients are on AZT . METHODS: Commun
A retrospective study on the effect of Megace on body weight in HIV patients, who had lost more than 5% body weight: its efficacy and its limitation as a form of treatment for weight loss.: Int Conf AIDS. 1990 Jun 20-23;6(1):170 (abstract no. Th.B.211). Unique Identifier : AIDSLINE ICA6/10021190; Chen W; Brown S; Gazzard B; Howard L; Westminster Hospital, London, UK; OBJECTIVE: To evaluate the effect of Megace on body weight in HIV patients with or without gastrointestinal disturbance. METHOD: Twenty-five patients, who had lost more than 5% body weight, given Megace (40-169mg) were weighted and reviewed 3 months prior to treatment and monthly thereafter. RESULT: 3 patterns of weig
AIDS-education and prevention in the workplace in Uganda.: Int Conf AIDS. 1990 Jun 20-23;6(1):171 (abstract no. Th.D.212). Unique Identifier : AIDSLINE ICA6/10021290; Rwakagiri F; Okware S; Federation of Uganda Employers, Uganda.; OBJECTIVE: The available data show that 85% of AIDS cases in Uganda is between 15 years to 55 years. This is the age that is in meaningful employment. In the absence of the drug nor vaccine against AIDS, in an effort to curtail the spread of AIDS, the employer has to devise means o
HIV infectivity program on Tap Air Portugal.: Int Conf AIDS. 1990 Jun 20-23;6(1):171 (abstract no. Th.D.213). Unique Identifier : AIDSLINE ICA6/10021390; Alves-Sa J; Sousa-Ura A; Sa-Leal A; Health Department, Tap Air Portugal, Lisboa, Portugal; At present, HIV infectivity in workplace is not only a medical problem since it concerns as well social, political, cultural, ethical and legal aspects. Any approach of workplace HIV infectivity must involve an increase in preventive measures in order to avoid new seropositives and protect against discrimination. The
Why do persons with HIV-related illness stop working?: Int Conf AIDS. 1990 Jun 20-23;6(1):171 (abstract no. Th.D.214). Unique Identifier : AIDSLINE ICA6/10021490; Yelin EH; Greenblatt R; Hollander H; McMaster J; University of California, San Francisco, USA; OBJECTIVE: To determine the risk factors (RF) for work disability (WD) among persons with HIV-related illness (HIV). WD is defined as total cessation of employment among those working at onset of illness. The RF analyzed include: symptoms and diagnoses of HIV, demographics, and the physical requirements and flexibilit
Training managers and supervisors on the law of AIDS in the United States.: Int Conf AIDS. 1990 Jun 20-23;6(1):171 (abstract no. Th.D.215). Unique Identifier : AIDSLINE ICA6/10021590; Nau CJ; Syntex Corporation, Palo Alto, California, USA; A key factor in the American civil rights revolution of the sixties and early seventies was not just the passage of federal and state anti-discrimination legislation but corporate America s response to those legal mandates and proscriptions. To properly recognize the rights of HIV-infected employees, as well as to pre
An evaluation of a workplace AIDS education intervention program focusing on HIV knowledge levels and attitudes toward gay men and people with AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):172 (abstract no. Th.D.216). Unique Identifier : AIDSLINE ICA6/10021690; Cowen E; Maddix J; DC Area Resource Center of Mid-Atlantic AIDS Education & Training; Center, Georgetown U., Washington, DC, USA; OBJECTIVE: The effectiveness of the Whitman-Walker Clinic s AIDS in the Workplace intervention program was evaluated. METHODS: Prior to attending the AIDS in the Workplace workshop developed and presented by staff members of the Whitman-Walker Clinic (D.C. s primary community-based AIDS service agency), 289 federal an
Large increase in health care utilization by HIV infected employees at a commercial bank in Kinshasa, Zaire.: Int Conf AIDS. 1990 Jun 20-23;6(1):172 (abstract no. Th.D.218). Unique Identifier : AIDSLINE ICA6/10021890; Mposo N; Bertozzi S; Kamenga M; Doppagne A; Engele B; Ryder R; Projet SIDA, Kinshasa, Zaire; OBJECTIVE: To evaluate the impact of HIV infection on health care utilization at large service corporation in Zaire . METHODS: We used a previously identified cohort of HIV positive (ELISA/Western Blot) employees (n=90) at a large bank in Kinshasa and selected a seronegative contro
AIDS prevention in Brazilian enterprises.: Int Conf AIDS. 1990 Jun 20-23;6(1):172 (abstract no. Th.D.219). Unique Identifier : AIDSLINE ICA6/10021990; Moreira Lima MD; Rodrigues LG; Rodrigues JF Jr; National Division of Sexually Transmitted Diseases/AIDS-Ministry; of Health-Brazil; CONTEXT: Nearly 20 million individuals work in the approximately 3 million enterprises in Brazil . These individuals are predominantly in the age group 18-48, in which the majority of AIDS cases in the country falls. This fact led the STD/AIDS Division of the Ministry of Health in B
The impact of workplace AIDS education on attitudes toward people with HIV/AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):173 (abstract no. Th.D.220). Unique Identifier : AIDSLINE ICA6/10022090; Leonard J; Hartfield K; Smith K; Seattle-King County Department of Public Health, Seattle,; Washington, USA; OBJECTIVE: To measure the impact of workplace AIDS education on employee knowledge and attitudes about people with AIDS and people at risk for HIV infection. METHODS: We developed a two-hour curriculum, augmenting our standard AIDS 101 curriculum with additional materials on AIDS-related prejudice, discrimination, and
The open-box condom policy in the workplace in Africa: effects on attitudes and practices.: Int Conf AIDS. 1990 Jun 20-23;6(1):173 (abstract no. Th.D.221). Unique Identifier : AIDSLINE ICA6/10022190; Tavrow PA; USAID, Dar es Salaam, Tanzania; OBJECTIVE: To test whether making condoms easily, reliably, and anonymously available to employees in workplaces in Dar es Salaam, in the absence of active promotion or counseling, leads to changed attitudes and practices in regard to sexual behavior of urban African men and women. METHODS: Starting in mid-1988, sever
Still on the job; the Army's experience with the workplace management of the HIV+ soldier.: Int Conf AIDS. 1990 Jun 20-23;6(1):173 (abstract no. Th.D.222). Unique Identifier : AIDSLINE ICA6/10022290; Vernon DM; Walter Reed Retrovirology Research Working Group, Walter Reed; Army Institute of Research, USA; OBJECTIVE: Examines the effect of the Army s AIDS policy on the military worksite. METHODS: Thirteen HIV+ soldiers were followed from diagnosis (late 1986, early 1987) until late November 1988. Initially diagnosed in Europe, these male soldiers and their commanders were interviewed pre-transfer to a US post (T1), one
Workplace training in an international non-governmental organisation.: Int Conf AIDS. 1990 Jun 20-23;6(1):173 (abstract no. Th.D.223). Unique Identifier : AIDSLINE ICA6/10022390; Couteau P; Wallace B; Michael L; Brever N; League of Red Cross and Red Crescent Societies, Geneva,; Switzerland; OBJECTIVE: To describe AIDS workplace training in a multicultural international organisation, including policy development, in which non-discrimination and integration of AIDS activities into staff s on-going work are stressed. METHODS: Using extensive interviews and consultation with staff members from all regions of
Molecular dynamics simulations of HIV-1 protease monomer and binding of inhibitors to the dimer in solution.: Int Conf AIDS. 1990 Jun 20-23;6(1):176 (abstract no. Th.A.225). Unique Identifier : AIDSLINE ICA6/10022590; Venable RM; Brooks BR; Carson FW; CBER, FDA, Bethesda, MD 20892, USA; OBJECTIVES: The goals of this investigation were to simulate motions of one of the 99-residue subunits of the HIV-1 protease homodimer and to analyze binding of inhibitors to the active dimeric enzyme. METHODS: The X-ray crystallographic structure of HIV-1 protease determined by Wlodawer et al. [Science, 245, 616-621
Inhibitors of HIV protease.: Int Conf AIDS. 1990 Jun 20-23;6(1):176 (abstract no. Th.A.226). Unique Identifier : AIDSLINE ICA6/10022690; Martin JA; Broadhurst AV; Galpin S; Handa BK; Kinchington D; Krohn A; Lambert RW; Machin PJ; Merrett JH; Parkes KE; et al; Roche Products Ltd., Welwyn Garden City, Hertfordshire, England; OBJECTIVE: Design, synthesis and biological evaluation of protease inhibitors as potential therapeutic agents for the treatment of HIV infection. METHODS: An analysis of the primary cleavage sites in gag and gag-pol suggested a series of small synthetic substrat
A fluoroquinolone (DR-3355) protects human lymphocyte cell lines from HIV-1-mediated cytotoxicity.: Int Conf AIDS. 1990 Jun 20-23;6(1):176 (abstract no. Th.A.227). Unique Identifier : AIDSLINE ICA6/10022790; Furusawa M; Renard J; Iino T; Sato Y; Marumoto Y; Ohta G; Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan; OBJECTIVE: To analyze the function of the 1-isomer of ofloxacin (DR-3355) to protect HIV-1-infected human lymphocyte cell lines. METHODS: The d-isomer (DR-3354) or l-isomer (DR-3355) of ofloxacin was added to the medium in which HIV-1-infected CEM cells were inoculated. Viable cell number, viability, HIV antigen-posit
Inhibition of HIV replication and cytopathicity in vitro by synthetic soluble melanins.: Int Conf AIDS. 1990 Jun 20-23;6(1):177 (abstract no. Th.A.228). Unique Identifier : AIDSLINE ICA6/10022890; Candia AF; Modliszewski M; Shaff DI; Montefiori DC; Department of Pathology, Vanderbilt University Medical School,; Nashville, TN, USA; OBJECTIVE: To study the antiviral activity of a variety of synthetic soluble melanins against HIV-1 and HIV-2 in vitro. METHODS: Soluble melanins were synthesized by spontaneous oxidation of L-dopa, L-dopamine, norepinephrine and 5-hydroxytryptamine, and by chemical oxidation of L-tyrosine. Their antiviral activities
Anti-HIV activity of porphyrins and phthalocyanines in vitro.: Int Conf AIDS. 1990 Jun 20-23;6(1):177 (abstract no. Th.A.229). Unique Identifier : AIDSLINE ICA6/10022990; Kato A; Higuchi H; Kaji H; Jefferson Medical College, Philadelphia, PA, USA; OBJECTIVE: To assess the anti-HIV effect of porphyrin and phthalocyanine derivatives for development of possible new anti-HIV drugs. METHODS: MT-4 cells or SUP-T1 cells, (2x10(4) cells) were infected with HIV-1 at 10 to 20 TCID50. Then HIV-infected cells and non-infected counterparts were cultured in the presence or a
Papaverine hydrochloride: effects on HIV replication and T-lymphocyte cell function.: Int Conf AIDS. 1990 Jun 20-23;6(1):177 (abstract no. Th.A.230). Unique Identifier : AIDSLINE ICA6/10023090; Nokta M; Albrecht T; Pollard R; Division of Infectious Diseases, The University of Texas Medical; Branch, Galveston, Texas, USA; OBJECTIVE: It was previously reported that the replication of viruses such as cytomegalovirus and measles was sensitive to papaverine (PAP). In this report the effect of PAP on HIV replication and T lymphocyte cell function were investigated. METHODS: MT-4 cell line was infected wi
The synthesis, biological evaluation, and structure activity of amido phosphocholines and related analogs as anti-HIV-1 agents.: Int Conf AIDS. 1990 Jun 20-23;6(1):177 (abstract no. Th.A.231). Unique Identifier : AIDSLINE ICA6/10023190; Marasco C; Piantadosi C; Meyer K; Kucera L; University of North Carolina at Chapel Hill School of Pharmacy,; Chapel Hill, N.C., USA; OBJECTIVE: The aim of this research is to develop and synthesize ether lipid analogues as anti-HIV-1 agents which inhibit viral assembly at the plasma membrane. The development of agents acting via mechanisms other than the inhibition of reverse transcriptase should act complementary to
Effects of GLQ223(TM) on synthesis and accumulation of HIV and cellular proteins in acutely infected T cells, in vitro.: Int Conf AIDS. 1990 Jun 20-23;6(1):178 (abstract no. Th.A.232). Unique Identifier : AIDSLINE ICA6/10023290; Caldwell S; Abrams H; Kibort T; Shiba A; Ross B; Wang M; Lifson J; Genelabs Incorporated, Redwood City, California, USA; OBJECTIVE: To evaluate the effects of GLQ223(TM) treatment on synthesis and accumulation of HIV and cellular proteins in acutely infected T cells in vitro. METHODS: Transformed T cells (VB cell line) were acutely infected with HIV-1DV and treated with GLQ223(TM) or, in some experiments, with the protein synthesis inhi
Effects of GLQ223(TM) on HIV and cellular RNA species from acutely infected T cells.: Int Conf AIDS. 1990 Jun 20-23;6(1):178 (abstract no. Th.A.233). Unique Identifier : AIDSLINE ICA6/10023390; Luk KC; Caldwell S; Lifson J; Genelabs Incorporated, Redwood City, California, USA; OBJECTIVE: Evaluation of the effects of GLQ223(TM) treatment on HIV-1 and cellular RNA species from acutely infected T cells. METHODS: Transformed T cells (VB cell line) were acutely infected with HIV-1DV and treated with GLQ223(TM). At various times post-infection, RNA from paired non-infected and HIV-infected cultur
Immunoadhesin-antibody hybrids for AIDS therapy.: Int Conf AIDS. 1990 Jun 20-23;6(1):178 (abstract no. Th.A.234). Unique Identifier : AIDSLINE ICA6/10023490; Berg J; Loetscher E; Steimer K; Capon D; Jack HM; Wabl M; Department of Microbiology and Immunology and Laboratory of; Radiobiology and Environmental Health, University of California,; San Francisco, California, USA; The human immunodeficiency virus (HIV) uses the cell surface protein CD4 as a receptor for infection. Cells expressing CD4 are mainly T helper lymphocytes, which are decreased in number after infection. This impairs the host s immunity, leading to development of the acquired immunodeficiency syndrome (AIDS). Although
The sulfated sugar alpha-cyclodextrin sulfate (A-CDS) is a potent anti-HIV agent, has marked synergism with AZT, and exhibits lymphoproliferative activity.: Int Conf AIDS. 1990 Jun 20-23;6(1):178 (abstract no. Th.A.235). Unique Identifier : AIDSLINE ICA6/10023590; Anand R; Nayyar S; Pitha J; Food and Drug Administration, Bethesda, Maryland, USA; OBJECTIVE: To determine if A-CDS exhibits anti-HIV activity and acts synergistically with AZT . METHODS: A-CDS was evaluated for its inhibitory effect on HIV-1BRU (LAV-1) replication and compared with other sulfated sugars like sodium pentosan polysulfd
Sulfated polymers are potent inhibitors of HIV replication and giant cell formation.: Int Conf AIDS. 1990 Jun 20-23;6(1):179 (abstract no. Th.A.236). Unique Identifier : AIDSLINE ICA6/10023690; De Clercq E; Schols D; Baba M; Pauwels R; Low M; Gorog S; Rega Institute for Medical Research, K.U.Leuven, B-3000 Leuven,; Belgium; OBJECTIVE: Since sulfated polysaccharides, e.g. dextran sulfate, are potent inhibitors of HIV in vitro, we investigated several synthetic sulfated polymers, namely sulfated polyvinyl alcohol (PVAS) and copolymers of acrylic acid with sulfated vinyl alcohol (PAVAS), for their anti-HIV activity. METHODS: Anti-HIV activid
Inhibitory effect of Chinese herbal medicines on HIV-1 infection in vitro.: Int Conf AIDS. 1990 Jun 20-23;6(1):179 (abstract no. Th.A.237). Unique Identifier : AIDSLINE ICA6/10023790; Li XL; Mohri H; Chia J; Kim T; Hoang V; Chang H; Ho DD; UCLA School of Medicine and Cedars-Sinai Medical Center, Los; Angeles, CA, USA; OBJECTIVE: To screen for HIV-1 inhibitory activity in Chinese herbal medicines which are known to be non-toxic in clinical use. METHODS: Each of 56 Chinese herbal extracts was tested in vitro to determine the toxic dose on cultured T cells. Sub-toxic doses of the medicines were then examined for HIV-1 inhibitory activd
Mechanism of action of inhibition of HIV infection by sulphated polyanions.: Int Conf AIDS. 1990 Jun 20-23;6(1):179 (abstract no. Th.A.238). Unique Identifier : AIDSLINE ICA6/10023890; Low L; Parish C; Fenning G; Warren H; Dalgleish A; Cunningham AL; Virology Unit, Westmead Hospital, Sydney, Australia; OBJECTIVE: To study the mode of action of sulphated polyanions (SP) in inhibiting HIV infection in vitro. METHODS: Anti-HIV activity was detected by inhibition of cytopathic effect and HIV antigen production by MT4 cells. Immunofluorescence and flow cytometry were used to study inhibition of anti-CD4 Mab binding. Bindd
The expression of HIV integrase as a fusion protein in E. Coli.: Int Conf AIDS. 1990 Jun 20-23;6(1):179 (abstract no. Th.A.239). Unique Identifier : AIDSLINE ICA6/10023990; Pemberton IK; Levantis P; Oxford J; The London Hospital Medical College, London, England; OBJECTIVE: To clone and express the HIV integrase (endonuclease) as a possible target for the action of novel antiviral compounds. METHODS: The plasmid pBT.1, containing the major Sst I fragment of the HIV-1 genome, provided the source of the integrase (p34pol) sequence for amplification by the polymerase chain reactid
Development of ribozymes that cleave HIV mRNA.: Int Conf AIDS. 1990 Jun 20-23;6(1):180 (abstract no. Th.A.240). Unique Identifier : AIDSLINE ICA6/10024090; James W; Crisell P; Sir William Dunn School of Pathology, University of Oxford, South; Parks Road, Oxford, OX1 3RE, UK; OBJECTIVE: To develop HIV mRNA-targeted ribozymes with optimized structures for RNA cleavage in vitro and in vivo. METHODS: We have taken an inhibitory antisense gene, AR2, derived from the region of the HIV provirus containing the first coding exon of tat (see Rhodes & James, accompanying abstract) and have introd
Effect of 2'3'-didehydro-3'deoxythymidine (d4T) on p24 antigenemia in patients with AIDS or ARC.: Int Conf AIDS. 1990 Jun 20-23;6(1):180 (abstract no. Th.A.241). Unique Identifier : AIDSLINE ICA6/10024190; Squires KE; Weiss W; Sacks H; Hassett J; Gugliotti R; Murray H; Cornell Medical College, NY, NY, USA; In a phase I dose-escalation trial, twenty patients (four groups of five) received 2, 4, 8, or 12 mg/kg/day of the thymidine nucleoside analog, d4T , a potent inhibitor of HIV replication in vitro. Sixteen patients completed greater than or equal to 10
Reporter gene signal activation by HIV-1: adaptation for antiviral drug screening.: Int Conf AIDS. 1990 Jun 20-23;6(1):180 (abstract no. Th.A.242). Unique Identifier : AIDSLINE ICA6/10024290; Polsky B; Mallon R; Dasmahapatra B; Borkowski JA; MacLow C; Baron PA; Gold JW; Schwartz J; Armstrong D; Memorial Sloan-Kettering Cancer Center, New York, New York, USA; OBJECTIVE: Development of an anti-HIV-1 drug screening system based on expression of the lacZ (beta-galactosidase) gene under control of the HIV-1 5 long terminal repeat (LTR). METHODS: HeLa T4+ cells were transfected by electroporation with 200 mug of the plasmid pLRON (containing lacZ as a reporter gene under the c
Anti-HIV-1 combination effects of antisense oligonucleotide (S-dC-28) with AZT, interferon alpha (IFN) and dextran sulfate-8000 (DS).: Int Conf AIDS. 1990 Jun 20-23;6(1):180 (abstract no. Th.A.243). Unique Identifier : AIDSLINE ICA6/10024390; Chou TC; Zhu QY; Stein C; Memorial Sloan-Kettering Cancer Center, N.Y., N.Y., USA; OBJECTIVE: To determine the in vitro anti-HIV-1 effects of combining S-dC-28 (a phosphorothioate oligodeoxycytidine 28 mer) with other anti-HIV agents AZT , IFN and DS which have different modes of action. METHODS: MT4 cells were exposed to HIV-1 at 37k
HIV-1 replication is reduced by antisense-RNA expression.: Int Conf AIDS. 1990 Jun 20-23;6(1):181 (abstract no. Th.A.244). Unique Identifier : AIDSLINE ICA6/10024490; Sczakiel G; Pawlita M; Deutsches Krebsforschungszentrum, Heidelberg, FRG; OBJECTIVE: Intracellular expression of antisense-RNAs targeted to viral sequences have been shown to exert anti-retroviral activity (e.g.: RSV). Here we address the question whether HIV-1 antisense-RNA expressed transiently or in stable transfectants is capable of inhibiting HIV-1 replication. METHODS: An antisense-RNk
Inhibition of HIV replication in cell culture by endogenously synthesized antisense RNA.: Int Conf AIDS. 1990 Jun 20-23;6(1):181 (abstract no. Th.A.245). Unique Identifier : AIDSLINE ICA6/10024590; Rhodes A; James W; Sir William Dunn School of Pathology, University of Oxford, South; Parks Road, Oxford, OX1 3RE, UK; OBJECTIVE: To determine whether antisense RNA could inhibit HIV replication and, if so, which HIV mRNA sequences provide the best targets for inhibition by antisense RNA. METHODS: A nested set of five antisense genes were derived from the HIV-1 IIIB provirus in the region of the first coding exon of the tat gene and ak
Phosphate-methylated HIV-1 TAR loop DNA sequences hamper virus spread pre- and post-integration.: Int Conf AIDS. 1990 Jun 20-23;6(1):181 (abstract no. Th.A.246). Unique Identifier : AIDSLINE ICA6/10024690; Smit L; Goudsmit J; Jurriaans S; Geelen JL; Van Genderen M; Buck H; Human Retrovirus Laboratory, Academic Medical Center, Amsterdam,; the Netherlands; OBJECTIVE: To examine the effect on HIV replication of phosphate-methylated (pm) antisense and sense oligodeoxynucleotides of 20 nucleotides in length, derived from the HXB2 TAR loop sequence. METHODS: C8166-cells were infected with different HIV strains (HX10, HTLV-IIIB, HTLV-IIIRF, LAV-2, RUT) in the presence of pm k
Inhibition of HIV-1 replication in CD4+ T cells by pokeweed antiviral protein conjugated to monoclonal antibody against CD4.: Int Conf AIDS. 1990 Jun 20-23;6(1):181 (abstract no. Th.A.247). Unique Identifier : AIDSLINE ICA6/10024790; Zarling J; Moran P; Haffar O; Sias J; Ledbetter J; Uckun F; Oncogen, Seattle, WA, USA; OBJECTIVE: Pokeweed antiviral protein (PAP) is a 30,000 kD MW protein from pokeweed plants which inhibits replication of certain plant and mammalian viruses. We asked whether PAP would inhibit replication of HIV-1 in CD4+ T cells and if PAP targeted to CD4+ cells by conjugation with mAb to CD4 would be more effective.k
CD4-Pseudomonas exotoxin inhibits HIV replication synergistically with reverse transcriptase inhibitors in lymphocyte cultures and specifically kills infected monocyte/macrophage as well as lymphocyte cell lines.: Int Conf AIDS. 1990 Jun 20-23;6(1):182 (abstract no. Th.A.248). Unique Identifier : AIDSLINE ICA6/10024890; Ashorn P; Moss B; Berger EA; Laboratory of Viral Diseases, NIAID, NIH, Bethesda, MD, USA; OBJECTIVE: CD4(178)-PE40 is a genetically engineered hybrid protein consisting of the HIV gp120 binding region of CD4 linked to active domains of Pseudomonas aeruginosa exotoxin A. This protein selectively kills HIV-1 infected human T-cell lines (IC50 appr. 100 pM) and inhibits HIV-1 spread to uninfected cells. In thik
Structure-function relationship of CD4-PE hybrid toxins.: Int Conf AIDS. 1990 Jun 20-23;6(1):182 (abstract no. Th.A.249). Unique Identifier : AIDSLINE ICA6/10024990; Winkler G; Jakubowski A; Turner S; Liu T; Heanue T; Burrus B; McGray P; Rosa M; Griffiths B; Thomas D; et al; Biogen, Inc., Cambridge, Massachusetts, USA; OBJECTIVE: We wished to evaluate the structure-function relationship of hybrid toxins composed of CD4 and Pseudomonas exotoxin A (PE) in order to optimize specificity and potency. Furthermore, we were interested in the kinetics of internalization as well as the mechanism of membrane translocation in gp160/120 expressik
The interaction of recombinant soluble CD4 (sT4) and GP120 in normal human and AIDS patient plasma.: Int Conf AIDS. 1990 Jun 20-23;6(1):182 (abstract no. Th.A.250). Unique Identifier : AIDSLINE ICA6/10025090; Potts W; Van Horn R; Urbanski J; Fong KL; SmithKline Beecham Pharmaceuticals, King of Prussia,; Pennsylvania, USA; OBJECTIVE: To develop techniques to detect the association of sT4 with gp120 in human plasma and investigate the effects of various agents, eg. host antibody to gp120 and heparin, on that association. METHODS: A sandwich style ELISA assay was developed for detection of sT4/gp120 complex in spiked buffer and plasma. Imk
Whole blood distribution and quantitation of recombinant soluble CD4 (sT4) in HIV-infected plasma by single and double monoclonal based ELISAs directed to sT4 V1 and V4 regions.: Int Conf AIDS. 1990 Jun 20-23;6(1):182 (abstract no. Th.A.251). Unique Identifier : AIDSLINE ICA6/10025190; Crysler C; Boyle KE; Jonak Z; Oka M; Culp J; Urbanski JJ; Fong KL; Department of Drug Metabolism, SmithKline Beecham; Pharmaceuticals, King of Prussia, PA 19406 USA; OBJECTIVE: To determine the whole blood distribution of recombinant soluble CD4 (sT4), and develop monoclonal based ELISAs directed to both sT4 functional (V1) and C-terminal (V4) regions for clinical pharmacokinetic (PK) and metabolic studies of sT4 in plasma. METHODS: 125I-labeled and unlabeled SK&F sT4 were spik
Inhibition of the infectivity of HIV by different recombinant forms of CD4.: Int Conf AIDS. 1990 Jun 20-23;6(1):183 (abstract no. Th.A.252). Unique Identifier : AIDSLINE ICA6/10025290; Zverev V; Malushova V; Sidorov A; Zdanovsky A; Elinov V; Korneeva M; Pugach A; Yankovsky N; Andjaparidze O; Institute for Viral Preparations, Moscow, USSR; OBJECTIVE: To characterize anti-HIV properties of recombinant soluble CD4 and CD4(178)DTA, a recombinant protein containing the gp120-binding region of CD4 linked to the A-fragment of diphtheria toxin. The construction of a new recombinant CD4 mutant form with adhesion properties. METHODS: Molecular cloning for recomb
Anti-HIV-1 activity of CD4 synthetic oligopeptides.: Int Conf AIDS. 1990 Jun 20-23;6(1):183 (abstract no. Th.A.253). Unique Identifier : AIDSLINE ICA6/10025390; Cereda PM; Pagani L; Filice G; Rassu M; Mengoli C; Dettin M; Palu' G; Di Bello C; University of Pavia, Italy; OBJECTIVE: The aim of this study was to investigate the anti-HIV-1 activity of CD4 oligopeptides which represent the supposed binding site of HIV-1 gp120. METHODS: Two oligopeptides (37-53 and 37-55) spanning the CD4 V1J1 domain were synthesized by solid phase techniques. They were selectively modified by the addition
Selective killing of persistently HIV-1-infected cells by dimyristoylphosphatidylcholine liposomes conjugated with CD4(68-94) peptide: Int Conf AIDS. 1990 Jun 20-23;6(1):183 (abstract no. Th.A.254). Unique Identifier : AIDSLINE ICA6/10025490; Kumagai K; Nabeshima S; Ohki K; Ohmura K; Ikuta K; Ueda S; Kato S; Biotechnology Laboratory, Sumitomo Chem. Co. Ltd., Hyogo, Japan; OBJECTIVE: We previously reported selective killing of persistently HIV 1-infected cells by liposomes containing fragment A (Fr.A) of diphtheria toxin(1). Here we examined the selective killing activity of liposomes not containing Fr.A against the persistently HIV 1-infected cells. METHODS: Liposomes, which were prepa
The pyrimidine nucleoside 3'-deoxy-3'fluorothymidine (FLT) inhibits the replication of feline onco- and lenti-retroviruses in vitro and in vivo.: Int Conf AIDS. 1990 Jun 20-23;6(1):183 (abstract no. Th.A.255). Unique Identifier : AIDSLINE ICA6/10025590; Hardy WD Jr; Zuckerman EE; Boecker J; Corbishley J; Kong XB; Wantanabe KA; Polsky BW; Gold JW; Baron P; Chou TC; et al; Memorial Sloan Kettering Cancer Center, NY, NY, USA; OBJECTIVE: To evaluate the ability of FLT to inhibit the replication of feline onco- and lenti-retroviruses, the feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV), in vitro and in vivo. METHODS: The inhibitory effects of FLT were evaluated in vitro by the FeLV and FIV fluorescent focus reduction ass
Murine retrovirus-induced immunodeficiency disease: comparative effects of AZT and liposomal AZT monophosphate.: Int Conf AIDS. 1990 Jun 20-23;6(1):184 (abstract no. Th.A.256). Unique Identifier : AIDSLINE ICA6/10025690; Li JL; Felgner PL; Richman DD; Hostetler KY; Vical Inc., San Diego, CA, USA; OBJECTIVE: The LP-BM5 murine leukemia virus produces a disease in C57BL/6 mice with many features of AIDS (MAIDS) and has been shown to be responsive to treatment with zidovudine ( AZT ). Treatment of mice with 100 mg/kg/day by intraperitoneal (i.p.) in
Infrequent dosing of 9-(2-phosphonylmethoxyethyl) adenine (PMEA) results in an increased antiretroviral effect in vivo.: Int Conf AIDS. 1990 Jun 20-23;6(1):184 (abstract no. Th.A.257). Unique Identifier : AIDSLINE ICA6/10025790; Balzarini J; Naesens L; DeClercq E; Rega Institute for Medical Research, K.U.Leuven, B-3000 Leuven,; Belgium; OBJECTIVE: To examine the effect of different treatment schedules of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 3 -azido-2 ,3 -dideoxythymidine ( AZT ) on their anti-retrovirus activity in Moloney murine sarcoma virus (MSV)-infected newborn NMRI mic
Quantitative analysis of antiviral efficacy in the SCID-hu mouse by polymerase chain reaction.: Int Conf AIDS. 1990 Jun 20-23;6(1):184 (abstract no. Th.A.258). Unique Identifier : AIDSLINE ICA6/10025890; Shih CC; O'Toole T; Salimi S; Kaneshima H; Namikawa R; Rabin L; McCune JM; SyStemix, Inc. 3400 West Bayshore Road, Palo Alto, CA., USA; The heterochimeric SCID-hu mouse is constructed by engrafting human hematolymphoid organs into the immunodeficient C.B17 scid/scid mouse. In a time- and dose-dependent manner, intravenous injection of HIV into these mice results in reproducible infection of the human organs, as detected by in situ hybridization, immun
Prevention of gp120-induced neuronal damage in the developing rat brain by peptide T: a Golgi study.: Int Conf AIDS. 1990 Jun 20-23;6(1):184 (abstract no. Th.A.259). Unique Identifier : AIDSLINE ICA6/10025990; Mervis RF; Hill JM; Brenneman DE; Div. Neuropath. Ohio State University, Columbus, OH, USA; OBJECTIVE: In vitro studies with murine hippocampus have shown that the HIV envelope glycoprotein, gp 120, induced neuronal death (Brenneman et al, Nature, 335,639, 1988; Drug Dev. Res. 15,361 1988). The goal of this study was to evaluate the in vivo effects of gp120 and peptide T on the morphology of cortical neurons
Pharmacokinetics of 3'-fluoro-3'-deoxythymidine (FDT), 3'-deoxy-2',3'-didehydrothymidine (D4T) and 3'-azido-2',3'-dideoxy-5-methylcytidine (AzddMeC) in monkeys.: Int Conf AIDS. 1990 Jun 20-23;6(1):185 (abstract no. Th.A.260). Unique Identifier : AIDSLINE ICA6/10026090; Boudinot FD; Schinazi RF; Doshi KJ; McClure HM; Qin YX; Chu CK; College of Pharmacy, University of Georgia, Athens, Georgia, USA; OBJECTIVE: To characterize the pharmacokinetics and bioavailability of FDT, D4T and AzddMeC in rhesus monkeys. METHODS: Monkeys were administered 60 mg/kg FDT, D4T or AzddMeC intravenously and orally. Monkeys were given 33.3 mg/kg FDT and D4T subcutaneously. Serial blood samples were obtained. Cerebrospinal fluid (CSF
Screening for antiretroviral agents against SIV in vitro.: Int Conf AIDS. 1990 Jun 20-23;6(1):185 (abstract no. Th.A.261). Unique Identifier : AIDSLINE ICA6/10026190; Tsai CC; Follis KE; Yarnall M; Deaver LE; Benveniste RE; Sager PR; Regional Primate Research Center, Univ. of Washington, Seattle,; WA, USA; Simian immunodeficiency virus (SIV), which causes an acquired immunodeficiency syndrome in macaques, is a lentivirus that is morphologically, antigenically, genetically, and biologically similar to the human immunodeficiency virus (HIV). Because of these similarities, the SIV model represents a unique opportunity for
Anti-HIV-1 activity of 3'-azido-2',3'-dideoxythymidine (AZT) in primary mononuclear phagocytes.: Int Conf AIDS. 1990 Jun 20-23;6(1):185 (abstract no. Th.A.262). Unique Identifier : AIDSLINE ICA6/10026290; Beenhouwer DO; Rankin JA; Mellors JW; Department of Internal Medicine, Yale University School of; Medicine and VA Medical Center, West Haven, CT, USA; OBJECTIVE: AZT has been reported to have greater anti-HIV-1 activity in fresh blood monocytes than in monocyte-derived macrophages which have differentiated in vitro. The activity of AZT in fresh tissue macrophages has not been well defined. We theref
In vitro study of drug-sensitivity of HIV strains isolated from patients with AIDS or ARC before and after therapy with AZT and/or 2',3'-dideoxycytidine (ddC).: Int Conf AIDS. 1990 Jun 20-23;6(1):185 (abstract no. Th.A.263). Unique Identifier : AIDSLINE ICA6/10026390; Shirasaka T; Yarchoan R; Aoki S; Ford H; DeVico A; Sarngadharan MG; Richman DD; Broder S; Mitsuya H; National Cancer Institute, Bethesda, MD, USA; OBJECTIVE: Study of HIV strains which developed drug-resistance may make it possible to identify more specific viral targets and to develop more effective therapeutic strategies. Four pairs of HIV-1 strains isolated from patients before and after therapy were analyzed for a possible mechanism of development of the dru
Effect of azidothymidine (AZT) in combination with double stranded RNA (Poly I: Poly C) on human immunodeficiency virus replication in T cells and monocyte-macrophages.: Int Conf AIDS. 1990 Jun 20-23;6(1):186 (abstract no. Th.A.264). Unique Identifier : AIDSLINE ICA6/10026490; Gohchi K; Sinet M; Dazza MC; Dameron G; Brun-Vezinet F; Laboratoire de Virologie, Hopital Bichat-Claude Bernard, Paris,; France; OBJECTIVE: To compare the effect of AZT in combination with Poly I: Poly C (pI pC) on MT4 cell line and monocyte-macrophages (M/M) infected with HIV. METHODS: HIV cytopathic effect in MT4 cells infected with HTLV-IIIB was evaluated using the reduction
Antiretroviral effects of glycerophospholipid stereoisomers of AZT on HIV replication in HT4-6C cells.: Int Conf AIDS. 1990 Jun 20-23;6(1):186 (abstract no. Th.A.265). Unique Identifier : AIDSLINE ICA6/10026590; Kumar R; Richman DD; Hostetler KY; Vical Inc, San Diego, CA, USA; OBJECTIVE: Macrophages are an important target for anti-HIV therapies. We previously reported the synthesis of sn-3 phosphatidylAZT (pAZT), a phospholipid prodrug of azidothymidine (AZT, zidovudine) which was active in HIV-infected cells. pAZT can be targeted to macrophages in vivo. We wished to determine if the sn-1
Mechanism of inhibition by carbovir triphosphate of HIV reverse transcriptase and human DNA polymerases, compared with the action of AZT triphosphate and dideoxynucleoside triphosphates.: Int Conf AIDS. 1990 Jun 20-23;6(1):186 (abstract no. Th.A.266). Unique Identifier : AIDSLINE ICA6/10026690; White EL; Shaddix SC; Vince R; Shannon WM; Parker WB; Southern Research Institute, Birmingham, AL, USA; Carbovir (carbocyclic 2 ,3 -didehydro-2 ,3 -dideoxyguanosine; NSC 614846) is a potent inhibitor of HIV replication which is presumed to exert its effect by the same mechanism as other dideoxynucleosides, such as ddA, ddC or
Halogenated congeners of 2',3'-dideoxypurine nucleosides active against HIV in vitro: a new class of lipophilic prodrug.: Int Conf AIDS. 1990 Jun 20-23;6(1):186 (abstract no. Th.A.267). Unique Identifier : AIDSLINE ICA6/10026790; Shirasaka T; Murakami K; Ford H; Kelley J; Yoshioka H; Kojima E; Aoki S; Driscoll JS; Broder S; Mitsuya H; National Cancer Institute, Bethesda, MD, USA; OBJECTIVE: Lipophilicity of 2 ,3 -dideoxypurine (ddP) nucleosides is generally low and their penetration into the central nervous system is not likely to be efficient. Generation of lipophilic antiretroviral drugs may have direct clinical relevance to the therapy of HIV infection. METHODS: Four 2-amino-6-halo-ddP and
Novel 6-substituted acyclouridine derivatives as highly specific inhibitors of HIV-1.: Int Conf AIDS. 1990 Jun 20-23;6(1):187 (abstract no. Th.A.268). Unique Identifier : AIDSLINE ICA6/10026890; Baba M; Tanaka H; Miyasaka T; Ubasawa M; Walker RT; De Clercq E; Fukushima Medical College, Fukushima, Japan; OBJECTIVE: To develop an effective chemotherapy for AIDS, novel 6-substituted acyclouridine derivatives were synthesized and examined for their inhibitory effects on HIV in vitro and their pharmacokinetics in vivo. METHODS: 1-[(2-Hydroxyethoxy)methyl]-6-phenylthiothymine (HEPT) and its derivatives were examined for th
Synthesis and inhibition of HIV-1 and HIV-2 activity by naphthalenedisulfonic acid spacer derivatives.: Int Conf AIDS. 1990 Jun 20-23;6(1):187 (abstract no. Th.A.269). Unique Identifier : AIDSLINE ICA6/10026990; Mohan P; Singh R; Baba M; University of Illinois at Chicago, Chicago, Illinois, USA; OBJECTIVE: Synthesis and evaluation of naphthalenedisulfonic acid derivatives for anti-HIV-1 and anti-HIV-2 activity. METHODS: Anti-HIV activity was determined by measuring inhibition of (1) HIV-1 and HIV-2 cytopathogenicity (2) HIV-1 giant cell formation and (3) HIV-1 reverse transcriptase (RT) activity. RESULTS: Sig
The effects of 5'-hydrogenphosphonates and 5'-methylphosphonates of pyrimidine nucleosides against HIV-1 replication in vitro.: Int Conf AIDS. 1990 Jun 20-23;6(1):187 (abstract no. Th.A.270). Unique Identifier : AIDSLINE ICA6/10027090; Zhu QY; Watanabe KA; Krayevsky AA; Tarussova NB; Polsky BW; Gold JW; Baron P; Hardy W; Armstrong D; Chou TC; Memorial Sloan-Kettering Cancer Center, NY, NY; OBJECTIVE: To evaluate in vitro anti-HIV activity of 5 -hydrogenphosphonates (HP) and 5 -methylphosphonates (MeP) of pyrimidine nucleosides and to determine their structure-activity relationships and selectivity. METHODS: The inhibitory effects of the compounds on HIV-1 replication were evaluated by HIV-1 P24 core ant
Anti-HIV activities of novel nucleosides analogs: acyclic and tricyclic base nucleosides.: Int Conf AIDS. 1990 Jun 20-23;6(1):187 (abstract no. Th.A.271). Unique Identifier : AIDSLINE ICA6/10027190; Clayette P; Merrouche Y; Roques P; Olomucki M; Dormont D; SSA/DPS/SPE CEA, Fontenay-aux-roses, France; OBJECTIVE: Nucleosides analogs are the most effective agents in the treatment of HIV infections. Because toxicity and viral resistance have been described, two series of new nucleosides derivatives, acyclic nucleosides and tricyclic base nucleosides, were screened against HIV1. METHODS: First, mitogenic and toxic effe
Antiviral activity of acriflavine and other acridine analogues as measured in vivo in friend leukemia virus carrying mice and in vitro on HIV-1 infected cells.: Int Conf AIDS. 1990 Jun 20-23;6(1):188 (abstract no. Th.A.272). Unique Identifier : AIDSLINE ICA6/10027290; Mathe G; Trabaud M; Bourut C; Chenu E; Institut du Cancer et d'Immunogenetique Hopital Paul-Brousse,; 94800-Villejuif, France; In vivo, DBA/2 mice inoculated with Friend s leukemia virus, were treated by i.p. route during 7 days with acriflavine-hydrochloride (ACF-HCl), or the neutral form of ACF (ACF-N) or by proflavin (PF), acridine (ACD), aminacrine (AAC) or tetrahydro amino acridine (THA) hydrochlorides and acridine yellow (ACD-y). Their
Synthesis of a series of tetrahydro-imidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-ones and thiones with potent and selective in vitro anti HIV-1 activity.: Int Conf AIDS. 1990 Jun 20-23;6(1):188 (abstract no. Th.A.273). Unique Identifier : AIDSLINE ICA6/10027390; Kukla MJ; Breslin H; Janssen MA; Raeymaeckers A; Van Gelder J; Janssen PA; Janssen Research Foundation, Spring House, Pennsylvania, 19477; USA; OBJECTIVE: Develop a potential anti-AIDS candidate from an initial lead compound (R14458) which is structurally distinct from the dideoxynucleosides such as AZT , DDI, and DDC but has moderate and specific activity against HIV-1. METHODS: Several analo
Inhibition of hepatitis B virus (HBV) replication in HBV-producing hepatoma cells by 2',3'-dideoxynucleosides in vitro.: Int Conf AIDS. 1990 Jun 20-23;6(1):188 (abstract no. Th.A.274). Unique Identifier : AIDSLINE ICA6/10027490; O'Brien M; Aoki S; Fujii H; Ford H; Broder S; Mitsuya H; National Cancer Institute, Bethesda, Maryland, USA; OBJECTIVE: Many HIV-infected individuals are co-infected with HBV. The HBV infection is an increasingly serious problem among homosexuals and intravenous drug abusers. The life cycle of hepadnaviruses involves a step of reverse transcription similar to that of retroviruses. We therefore asked if antiretroviral DNA-cha
Immune activation and immune deficiency changes during a longitudinal study of SIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):188 (abstract no. Th.A.275). Unique Identifier : AIDSLINE ICA6/10027590; Shum A; McGraw T; Vowels B; Gardner M; Hofmann B; Fahey JL; UCLA School of Medicine, Los Angeles, CA, USA; OBJECTIVE: To determine the changes in serum markers of immune activation in lymphoid subsets during the course of SIV infection in rhesus monkeys. METHODS: 2 groups of 4 rhesus macaque monkeys were infected with SIV and tested at approximately monthly intervals for 9 and 18 months. Beta-2 microglobulin (B2M) and neop
A new immunodeficiency virus isolate from a wild captured chimpanzee: SIVcpz-ant-1.: Int Conf AIDS. 1990 Jun 20-23;6(1):189 (abstract no. Th.A.276). Unique Identifier : AIDSLINE ICA6/10027690; Peeters M; Fransen K; Delaporte E; Van den Haesevelde M; Saman E; van der Groen G; Piot P; Institute of Tropical Medicine, Antwerp, Belgium; OBJECTIVE: Actually, only 2 chimpanzees, naturally infected with a novel HIV-related virus have been described. Both animals originated from Gabon and from one a novel retrovirus SIVcpz was isolated. The aim of this study was to better define the prevalence of this virus in chimpanz
Investigations into the genetic and immunological basis for the lack of pathogenesis of SIVagm in its natural host, the African green monkey (AGM).: Int Conf AIDS. 1990 Jun 20-23;6(1):189 (abstract no. Th.A.277). Unique Identifier : AIDSLINE ICA6/10027790; Kurth R; Norley SG; Kraus G; Hartung S; Ennen J; Baier M; Cichutek K; Paul Ehrlich Institute, Langen/Frankfurt, West Germany; OBJECTIVE: To determine the reasons for the lack of pathogenesis of SIVagm in order to better understand the mechanisms of pathogenicity of HIV. METHODS: Isolation, molecular cloning, genome sequencing and protein analysis. Evaluation of the anti-viral immune response, intracellular control of viral expression and vir
Induction of IL-6 in SIV/SMM-PBj infection: evidence for a cytokine mediated disease.: Int Conf AIDS. 1990 Jun 20-23;6(1):189 (abstract no. Th.A.278). Unique Identifier : AIDSLINE ICA6/10027890; Birx D; Lewis M; Vahey M; Zack P; Jahrling P; Burke D; Redfield R; Division of Retrovirology, WRAIR, Rockville, MD, USA; OBJECTIVE: Determination of cytokine levels and IL-6 mRNA in 3 species of macaques (Rhesus n=8, Cynomolgus n=4, and Pigtailed n=4) following infection with the SIV/SMM-PBj clone; correlation with disease pathogenesis. METHODS: Cytokine levels in the 16 monkeys (4 Rhesus survivors) were determined by IL-6 (B9 bioassay
Malignant lymphomas in SIV infected cynomolgus monkeys.: Int Conf AIDS. 1990 Jun 20-23;6(1):189 (abstract no. Th.A.279). Unique Identifier : AIDSLINE ICA6/10027990; Feichtinger H; Putkonen P; Parravicini C; Bottiger D; Biberfeld G; Biberfeld P; Immunopathology Lab., Karolinska Institute, Stockholm, Sweden; OBJECTIVE: To study pathogenic effects of simian immunodeficiency virus (SIV) in cynomolgus monkeys (Macaca fascicularis). METHODS: Monkeys were injected i.v. with SIV(SM) (courtesy of H. McClure, P. Fultz, Yerkes, Atlanta, GA, USA) and monitored for clinical symptoms, antibody response to SIV, CD4/CD8 lymphocyte rati
Localization of SIV antigen and RNA in the CNS of macaques with SIV encephalitis.: Int Conf AIDS. 1990 Jun 20-23;6(1):190 (abstract no. Th.A.280). Unique Identifier : AIDSLINE ICA6/10028090; Lackner A; Dandekar S; Smith MO; Marx PA; California Primate Research Center and Department of Medical; Pathology, University of California, Davis, California, USA; OBJECTIVE: To detect and localize SIV in the central nervous system of rhesus macaques with SIV encephalitis. METHODS: Six rhesus monkeys with histologic evidence of SIV encephalitis were examined by immunohistochemistry and in situ hybridization to localize SIV core protein (p27) and RNA and to phenotype the cellular
Persistent productive infection of rhesus macaques by different strains of HIV-2.: Int Conf AIDS. 1990 Jun 20-23;6(1):190 (abstract no. Th.A.281). Unique Identifier : AIDSLINE ICA6/10028190; Castro BA; Lerche NW; Nepomuceno M; Barboza A; Legg H; Levy JA; University of California, School of Medicine, San Francisco,; California, USA; OBJECTIVE: To develop an animal model of persistent HIV-2 infection using preselected susceptible animals and virus strains with high replicating ability. METHODS: Eight rhesus macaques were inoculated with 3 different HIV-2 strains (UC2, UC3, and UC7) isolated from peripheral blood mononuclear cells (PBMC) of patient
A feline model of the AIDS Dementia Complex (ADC)?.: Int Conf AIDS. 1990 Jun 20-23;6(1):190 (abstract no. Th.A.282). Unique Identifier : AIDSLINE ICA6/10028290; Wheeler DW; Whalen LR; Gasper PW; Overbaugh J; Depts of Anatomy & Neurobiology, Colorado State University, Ft.; Collins, CO, USA; OBJECTIVE: To determine the applicability of Feline Immunodeficiency Virus (FIV) infected cats as an animal model of HIV-induced AIDS Dementia Complex. METHODS: Cats used in this study were naturally infected with the recently discovered lentivirus, FIV, and tested positive for FIV infection and negative for the felin
Immunology of feline immunodeficiency virus (FIV) infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):190 (abstract no. Th.A.283). Unique Identifier : AIDSLINE ICA6/10028390; Ishida T; Taniguchi A; Washizu T; Tomoda I; Nippon Veterinary and Zootechnical College, Tokyo, Japan; OBJECTIVE: To study immunologic changes toward development of AIDS in cats infected with feline immunodeficiency virus (FIV). METHODS: Peripheral blood lymphocytes of FIV infected cats were assayed for Con A blastformation and IL-2 production. In vivo antibody producti
Molecular cloning of the Japanese isolates of feline immunodeficiency virus (FIV).: Int Conf AIDS. 1990 Jun 20-23;6(1):191 (abstract no. Th.A.284). Unique Identifier : AIDSLINE ICA6/10028490; Fukasawa M; Hasegawa A; Maki N; Miyazawa T; Kawamura M; Takahashi E; Mikami T; Hayami M; University of Kyoto, Kyoto, Japan; OBJECTIVE: Since there is only one FIV isolate in U.S. (Petaluma) which was totally sequenced, the second FIV isolate which was sequenced is necessary to know the general relationship of FIV to other lentiviruses and the pathogenicity of FIV. METHODS: Two strains of FIV, TM-1 and TM-2 were isolated and molecularly clo
Elimination of retroviruses from cats using allogeneic marrow transplantation.: Int Conf AIDS. 1990 Jun 20-23;6(1):191 (abstract no. Th.A.285). Unique Identifier : AIDSLINE ICA6/10028590; Gasper PW; Fulton R; Thrall MA; Oulton SA; Rose BJ; Overbaugh J; Pathology Dept., Colorado State University, USA; OBJECTIVE: To determine whether allogeneic marrow transplantation (BMT) combined with marrow from immunized donors or zidovudine ( AZT ) therapy could eliminate retrovirus from cats experimentally-infected with feline leukemia virus (FeLV). METHODS: Nin
Tissue distribution of FIV and relationship to pathogenesis in cats and comparison with the SIV model.: Int Conf AIDS. 1990 Jun 20-23;6(1):191 (abstract no. Th.A.286). Unique Identifier : AIDSLINE ICA6/10028690; Dandekar S; Martfeld DJ; Torten M; Rideout B; Luciw PA; Pedersen N; University of California, Davis, California, USA; OBJECTIVE: FIV is a T-lymphotropic lentivirus associated with AIDS-like disease in cats. The main objective of this study was to determine tissue distribution of FIV as well as histopathology in diseased animals. These findings were compared with our data from SIV-infected macaques and related to in vivo pathogenesis.
Sustained increases in cerebrospinal fluid quinolinic acid in rhesus macaques infected with simian immunodeficiency virus: relationship to neurologic signs.: Int Conf AIDS. 1990 Jun 20-23;6(1):191 (abstract no. Th.A.287). Unique Identifier : AIDSLINE ICA6/10028790; Heyes MP; Gravell M; London WT; Johnson P; Quearry BJ; Markey SP; Building 10, Section on Analytical Biochemistry, Rm 3D40, NIMH,; Bethesda, MD 20892, USA; AIDS patients may develop dementia , motor and psychiatric disturbances and at post mortem exhibit brain atrophy, white matter pallor and infiltrates of multinucleated giant cells. We have found increased concentrations of the endogenous neurotoxin, convulsant and kynurenine pathway
The effect of HIV-1 infection on specific immune responses in rabbits.: Int Conf AIDS. 1990 Jun 20-23;6(1):192 (abstract no. Th.A.288). Unique Identifier : AIDSLINE ICA6/10028890; Gordon MR; Dickerson D; Kindt TJ; Laboratory of Immunogenetics, National Institute of Allergy and; Infectious Disease, Bethesda, Md. 20892, USA; OBJECTIVE: HIV-1 infection of rabbit cells has been demonstrated in vitro and in vivo. Although HIV-1 could be detected in rabbits for as long as 1 year post-infection, no pathogenic effects attributable to viral infection were observed. The current study was designed to determine whether HIV-1 infection influenced ra
A murine model of CNS infection in AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):192 (abstract no. Th.A.289). Unique Identifier : AIDSLINE ICA6/10028990; Sei Y; Makino M; Vitkovic L; Kinjo J; Hartley JW; Torrence PF; Morse HC 3d; Arora PK; Laboratory of Neuroscience, NIDDK, National Institutes of Health,; Bethesda, MD 20892, USA; OBJECTIVE: A murine AIDS, characterized by profound immunosuppression associated with increased susceptibility to infection, develops in C57BL/6 mice inoculated with LP-BM5 murine leukemia viruses (MuLVs) [a mixture containing a defective genome, the critical component for disease induction, and helper ecotropic and m
Glomerulosclerosis in transgenic mice expressing HIV-1 genes.: Int Conf AIDS. 1990 Jun 20-23;6(1):192 (abstract no. Th.A.290). Unique Identifier : AIDSLINE ICA6/10029090; Dickie P; Bryant J; Notkins AL; Silver J; Felser JM; National Institute of Dental Research, National Institutes of; Health, Bethesda, Maryland, USA; OBJECTIVE: Development of a transgenic mouse model of HIV disease. METHODS AND RESULTS: Transgenic progeny from three founder mice bearing chromosomally integrated copies of HIV-1 proviral DNA (derived from pNL4-3 and rendered noninfectious by deletion of gag/pol sequences) developed renal disease characterized by foc
Generation of transgenic mice carrying HIV tat and nef genes.: Int Conf AIDS. 1990 Jun 20-23;6(1):192 (abstract no. Th.A.291). Unique Identifier : AIDSLINE ICA6/10029190; Dinchuk J; Cheng-Mayer C; Luciw P; Yoo-Warren H; Wirak D; Levy J; Molecular Therapeutics, Inc., West Haven, CT, USA; In an attempt to understand the functions of HIV gene products in vivo, we have generated transgenic mice which carry various copy numbers of HIV tat and nef genes under the control of the HIV LTR using standard microinjection techniques. We have generated 8 transgenic founders carrying the tat gene construct. Founder
HIV integration in a cell-free system.: Int Conf AIDS. 1990 Jun 20-23;6(1):193 (abstract no. Th.A.292). Unique Identifier : AIDSLINE ICA6/10029290; Ellison V; Abrams H; Roe T; Lifson J; Brown PO; Howard Hughes Medical Institute, Stanford University, Stanford,; CA USA; OBJECTIVE: To develop an in vitro system in which the HIV integration reaction is faithfully reproduced, then to use this system to study the molecular mechanism of the reaction. METHODS: Extracts from acutely-HIV-infected cells were incubated in a defined solution with plasmid or bacteriophage target DNA molecules. R
Characterization of acute HIV infection in the PBMC-reconstituted SCID mouse.: Int Conf AIDS. 1990 Jun 20-23;6(1):193 (abstract no. Th.A.293). Unique Identifier : AIDSLINE ICA6/10029390; Hesselton R; Koup RA; Sullivan JL; University of Massachusetts Medical Center, Department of; Pediatrics and Program in Molecular Medicine, Worcester,; Massachusetts, USA; OBJECTIVE: To investigate the SCID mouse reconstituted with human peripheral blood mononuclear cells (PBMC) (Mosier, et al.) as an animal model of HIV-1 infection. METHODS: SCID mice were reconstituted by intraperitoneal (IP) injection of 10-50x10(6) PBMC from human donors seronegative for Epstein-Barr virus. Presence
Xenochimeric SCID mice as a possible model for human antiviral immunity.: Int Conf AIDS. 1990 Jun 20-23;6(1):193 (abstract no. Th.A.294). Unique Identifier : AIDSLINE ICA6/10029490; Svedersky L; Roey S; Scillian J; Parslow T; Stites D; Department of Laboratory Medicine, UCSF, San Francisco,; California, USA; OBJECTIVE: To investigate the use of xenochimeric SCID mice as an in vivo model for human T and B cell immune responses to HIV antigens. METHODS: Male and female SCID mice, 6 to 12 weeks old, were used. One to 3 x 10(7) human peripheral blood lymphocytes, obtained from Ficoll-Hypaque density gradients of HIV seronegat
Development of an animal model to study HIV infection of human hematopoietic progenitor cells.: Int Conf AIDS. 1990 Jun 20-23;6(1):193 (abstract no. Th.A.295). Unique Identifier : AIDSLINE ICA6/10029590; Weilbaecher K; Namikawa R; McCune JM; SyStemix, Inc., Palo Alto, California, USA; Given indirect evidence that HIV may infect early hematopoietic precursors in man, we have sought to develop an animal model by which to examine infection of such cells experimentally. The heterochimeric SCID-hu mouse is constructed by transplantation of human fetal hematolymphoid tissue into the immunodeficient C.B17
Characterization of HIV-1 infected cells within the human lymphoid organs of the SCID-hu mouse.: Int Conf AIDS. 1990 Jun 20-23;6(1):194 (abstract no. Th.A.296). Unique Identifier : AIDSLINE ICA6/10029690; Namikawa R; Fedor J; Kaneshima H; McCune JM; SyStemix, Inc., Palo Alto, CA. USA; Little is known about the cell types initially infected within lymphoid organs. The heterochimeric SCID-hu mouse is constructed by transplantation of human fetal hematolymphoid tissues, including thymus, liver, and lymph node, into the immunodeficient C.B17 scid/scid mouse. These organs are infected after intra-thymic
T cell functions and phenotypes in SCID-hu mice.: Int Conf AIDS. 1990 Jun 20-23;6(1):194 (abstract no. Th.A.297). Unique Identifier : AIDSLINE ICA6/10029790; Krowka J; Sarin S; Namikawa R; McCune JM; Kaneshima H; SyStemix, Inc., Palo Alto, CA, USA; The heterochimeric SCID-hu mouse is constructed by the transplantation of human fetal lymphoid tissue into the congenitally immunodeficient C.B17 scid/scid mouse. Previous studies have demonstrated that SCID-hu mice can be infected by HIV and that antiviral compounds can inhibit HIV in these mice. The objective of thi
Monoclonal antibodies to SIV envelope proteins.: Int Conf AIDS. 1990 Jun 20-23;6(1):194 (abstract no. Th.A.298). Unique Identifier : AIDSLINE ICA6/10029890; Kent K; Gritz L; Cranage M; Silvera P; Corcoran T; Stott J; National Institute for Biological Standards and Control, Potters; Bar, UK; OBJECTIVE: To characterise the biological properties of mAbs to SIV envelope and to define antigenic differences between SIV and HIV strains. METHODS: Mice were primed with recombinant vaccinia virus vAbT 253 expressing the envelope gene of SIVmac251, and boosted with SIV-infected C8166 cells. Hybridomas were screened
Interference of SIVagmTYO-7 GP130 with human CD-4.: Int Conf AIDS. 1990 Jun 20-23;6(1):194 (abstract no. Th.A.299). Unique Identifier : AIDSLINE ICA6/10029990; Polzien F; Luke W; Traunecker A; Karjalainen K; Hunsmann G; German Primate Center, Gottingen, FRG; OBJECTIVE: The interaction of purified external glycoprotein (gp130) of a Simian immunodeficiency virus (SIV) isolated from an African green monkey (agm) with CD-4 on human MOLT-4 clone 8 cells and soluble CD4 (sCD4) was investigated. METHODS: gp130 was purified to homogeneity and iodinated to a specific activity of 1
Antibodies to SIVmac(K1) envelope-derived synthetic peptides identify shared antigenic determinants from related primate immunodeficiency virus isolates.: Int Conf AIDS. 1990 Jun 20-23;6(1):195 (abstract no. Th.A.300). Unique Identifier : AIDSLINE ICA6/10030090; Kanda P; Dunham RG; Shuler KR; Allan JS; Southwest Foundation for Biomedical Research, San Antonio, TX,; USA; OBJECTIVE: We raised antisera in rabbits against seven synthetic peptides analogous to regions within SIVmac(K1) gp120 and gp32 envelope glycoproteins to determine if these antisera would neutralize viral infectivity and also if they would crossreact with envelope glycoproteins from HIV-2ST, HIV-1, SIVAGM(tyo-1), and
Molecular studies of patas viral isolates from Senegal.: Int Conf AIDS. 1990 Jun 20-23;6(1):195 (abstract no. Th.A.301). Unique Identifier : AIDSLINE ICA6/10030190; Saksena N; Muller M; Deslandres A; Durand JP; Lang MC; Digoutte JP; Barre-Sinoussi F; Institut Pasteur, Paris, France; OBJECTIVE: To define molecularly these unknown isolates from Erythrocebus patas. METHODS: Cell culture, Southern blot analysis, polymerase chain reaction, restriction enzyme analysis, cloning and sequencing. RESULTS: Besides macaques, mandrills, African green monkeys and sooty mangabeys, patas is another group of monk
HTLV-I and HTLV-II infection in U.S. blood donors is associated with different risk factors.: Int Conf AIDS. 1990 Jun 20-23;6(1):195 (abstract no. Th.A.302). Unique Identifier : AIDSLINE ICA6/10030290; Lee HH; Sherwood WC; Smith DE; Tegtmeier GE; Fernando LP; Fang CT; Kleinman SH; Abbott Laboratories, N. Chicago, IL, USA; OBJECTIVE: To determine the respective prevalence of HIV-1, HTLV-I and HTLV-II in U.S. blood donors and assess risk factors. METHOD: Screening of 484,000 blood donors for HTLV-I/II and HIV antibodies was performed at 5 transfusion centers. HTLV-I seropositivity was confirmed by a combination of western blot and RIPA.
HTLV-I and HTLV-II seroprevalence among outpatients at a San Francisco public hospital.: Int Conf AIDS. 1990 Jun 20-23;6(1):195 (abstract no. Th.A.303). Unique Identifier : AIDSLINE ICA6/10030390; Murphy EL; Varney K; Hurt M; Bobey L; Eble B; Alexander S; Khayam-Bashi H; Vyas G; Univ. Cal., San Francisco, CA, USA; We measured antibodies to HTLV-I/II among clinic and emergency room patients at a public hospital in San Francisco. Unlinked serum and plasma were tested by HTLV-I ELISA (Dupont) and recombinant p21 Western blot HTLV-I and HTLV-II were presumptively differentiated on the basis of the relative intensities of the p19 an
Rapid serological determination of HTLV-I/II antibodies.: Int Conf AIDS. 1990 Jun 20-23;6(1):196 (abstract no. Th.A.304). Unique Identifier : AIDSLINE ICA6/10030490; Yajko DM; Gonzalez P; Lipka J; Chun P; Foung SK; Chu A; Ng VL; Hadley WK; University of California, San Francisco, California, USA; OBJECTIVE: To develop a rapid, sensitive, and specific serological test to detect the presence of HTLV-I/II antibodies. METHODS: Filter units, impregnated with HTLV-I virus lysate, which permit rapid serum flow-through while capturing antigen-specific antibodies; detection of immune complexes with Protein-A colloidal
An overview of the Department of Defense (DOD) HTLV-I/II testing experience: the first year.: Int Conf AIDS. 1990 Jun 20-23;6(1):196 (abstract no. Th.A.305). Unique Identifier : AIDSLINE ICA6/10030590; Roberts C; Fipps D; Burke D; Walter Reed Retroviral Research Group, USA; OBJECTIVE: To characterize the Human T-Lymphotropic Virus (HTLV-I/II) infected patient population for the DOD. METHODS: Repeatedly reactive sera were subsequently tested by Western blot (WB) and or Radioimmunoprecipitation (RIPA). The presence of antibody to p24 and gp46 (or gp61/68) was considered diagnostic for infe
Use of PCR amplification for diagnosis of HTLV-1 after blood transfusion.: Int Conf AIDS. 1990 Jun 20-23;6(1):196 (abstract no. Th.A.306). Unique Identifier : AIDSLINE ICA6/10030690; Agbalika F; Honderlick P; Ferchal F; Perol Y; Department of Bacteriology-Virology, St-Louis Hospital, Paris VII; University, France; OBJECTIVE: To confirm HTLV-1 infection after whole blood transfusion in two patients who seroconverted in ELISA but presented indeterminate western-blot. METHODS: Serial samples of 2 patients seronegative for HTLV-1 (ELISA and western-blot) receiving multiple whole blood transfusions were studied by ELISA (Abbott and
Development and characterization of an HTLV-I, II antigen capture ELISA.: Int Conf AIDS. 1990 Jun 20-23;6(1):196 (abstract no. Th.A.307). Unique Identifier : AIDSLINE ICA6/10030790; Pearlman S; Toedter G; Charie L; Looney S; Faerman L; Hofheinz D; Coulter Immunology, Hialeah, Florida, USA; OBJECTIVE: To develop an antigen capture ELISA for the detection of HTLV-I, II p24 antigen. METHODS: A murine monoclonal antibody was developed which demonstrates specificity for the core (p53, p24) protein of HTLV-I, II. The antibody was coated onto 96 well microelisa plates to form the capture phase of the assay. An
Establishment of HTLV-I immortalized rat cell lines.: Int Conf AIDS. 1990 Jun 20-23;6(1):197 (abstract no. Th.A.308). Unique Identifier : AIDSLINE ICA6/10030890; Tateno M; Sato H; Sakurai H; Ikeda H; Wakisaka A; Yoshiki T; Dept. of Pathology, Sapporo City General Hospital, Sapporo, Japan; OBJECTIVE: HTLV-I positive human cell lines are known to be easily infected by HIV-1. To develop animal models of AIDS or HIV-1 infection, we tried to establish HTLV-I producing rat cell lines. METHODS: WKA, LEW, F344 and ACI rats were used. The spleen cells from these rats were co-cultured with mitomycin-C (MMC) trea
IFA confirmation of HTLV-I/II antibodies.: Int Conf AIDS. 1990 Jun 20-23;6(1):197 (abstract no. Th.A.309). Unique Identifier : AIDSLINE ICA6/10030990; Abadom V; Rosebrock J; Hung CL; Okamoto D; Malamud M; Sheldon J; Pharmacia Diagnostics Inc. Columbia, Maryland, USA; OBJECTIVE: Previous studies (5th Consortium for Retrovirus Serology Standardization) have shown indirect immuno-fluorescence assay (IFA) can be used to confirm the presence of HTLV-I antibodies. This study was designed to show that IFA could be used to confirm the presence of HTLV-II antibodies. METHOD: 20 well catego
Type-specific identification of HTLVs by polymerase chain reaction (PCR): Int Conf AIDS. 1990 Jun 20-23;6(1):197 (abstract no. Th.A.310). Unique Identifier : AIDSLINE ICA6/10031090; Mitra R; Gildea J; Saxena E; Fowler A; Roberts C; Burke DS; SRA Technologies Inc., Rockville, Maryland, USA; OBJECTIVE: Development of Polymerase Chain Reaction (PCR) (1) to distinguish between HTLV-I and HTLV-II infection in patient cells. METHODS: PCR was performed in crude cell lysate using group specific primer pairs from selected regions of the HTLV genome. Reaction products were analyzed by solution hybridization with
Evaluation of three commercial screening tests for HTLV-I antibodies in a developing country.: Int Conf AIDS. 1990 Jun 20-23;6(1):197 (abstract no. Th.A.311). Unique Identifier : AIDSLINE ICA6/10031190; Muchinik G; Bouzas MB; DeRosa MF; Cahn P; Gallo D; Hanson C; Instituto de Investigaciones Hematologicas, Academia Nacional de; Medicina, Buenos Aires, Argentina; OBJECTIVE: To evaluate the performance of HTLV-I antibody screening tests in the laboratory of a developing country. METHODS: A panel of 136 sera, 67 of which were HIV-1 antibody positive, was screened for HTLV-I by ELISA ( Abbott Laboratories and Cambridge BioScience), by a partic
Evaluation of six enzyme immunoassays (EIA) for detection of antibody against human T-lymphotropic viruses types 1 and 2 (HTLV-1/2): Int Conf AIDS. 1990 Jun 20-23;6(1):198 (abstract no. Th.A.312). Unique Identifier : AIDSLINE ICA6/10031290; Kline R; Brothers T; Halsey N; Ruff A; Lairmore M; Quinn T; NIAID, NIH, Bethesda, MD, USA; OBJECTIVE: To evaluate the reliability, sensitivity and specificity of 6 HTLV-1/2 compared to Western blot (WB) and RIPA using sera from Haitian patients. METHODS: Sera from 1100 pregnant Haitian women were evaluated for HTLV-1/2 seropositivity using 6 different EIA Kits. The kits used were from Abbott, Cambridge Bios
Mutational analysis of the HTLV-I tax protein.: Int Conf AIDS. 1990 Jun 20-23;6(1):198 (abstract no. Th.A.313). Unique Identifier : AIDSLINE ICA6/10031390; Semmes OJ; Jeang KT; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Disease, National Institutes of Health,; Bethesda, Maryland, USA; OBJECTIVE: We have undertaken a mutational analysis of the HTLV-I Tax protein. Our goal is to examine the role of phosphorylation and zinc-binding of Tax on transactivation of the HTLV-I LTR. METHODS: Oligonucleotide-directed site mutagenesis was employed to analyze the amino acids of interest. Each of the 25 serine r
PCR analysis of intravenous drug user samples reactive with HTLV-I and HTLV-II.: Int Conf AIDS. 1990 Jun 20-23;6(1):198 (abstract no. Th.A.314). Unique Identifier : AIDSLINE ICA6/10031490; Shriver K; Oluoch E; Olmsted L; Masinovsky R; Fitzsimmons L; Schwebke J; Holmes K; Genetic Systems Corporation, Seattle, Washington, USA; OBJECTIVE: To use PCR analysis for confirmation and serotyping of intravenous drug user (IVDU) samples with serologic evidence of infection with HTLV-I/II. METHODS: Samples were screened initially by HTLV-I EIA (Genetic Systems). Reactive samples were analyzed by HTLV-I Western Blot and radioimmunoprecipitation. DNA p
Use of synthetic peptide based EIAs to distinguish HTLV-I from HTLV-II infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):198 (abstract no. Th.A.315). Unique Identifier : AIDSLINE ICA6/10031590; Hosein B; Present B; Fang C; Wang CY; United Biomedical, Inc., Lake Success, NY, USA; OBJECTIVE: To develop a convenient and reliable method to distinguish HTLV-I and HTLV-II infection. METHODS: Multiple overlapping peptides from gp46, the external portion of HTLV-I and HTLV-II envelope proteins, were synthesized and characterized. Peptides representing highly antigenic epitopes from each virus were id
Risk factors for PCR-determined HTLV-I and HTLV-II infection in northern California blood donors.: Int Conf AIDS. 1990 Jun 20-23;6(1):199 (abstract no. Th.A.316). Unique Identifier : AIDSLINE ICA6/10031690; Eble B; Busch M; Guiltinan A; Khayam-Bashi H; Vyas G; Murphy E; Dept. Lab. Med., Univ. Calif., San Francisco, California, USA; OBJECTIVE: Identify HTLV virus-type in HTLV antibody-positive individuals and correlate the occurrence of each virus with suspected risk factors. METHODS: We performed HTLV-type specific polymerase chain reaction (PCR) amplification for pol gene sequences on 16 randomly selected HTLV seropositive blood donors in North
Evaluation of sensitivity in the detection of human T lymphotropic virus I (HTLV-I) antibodies: is Western blot (WB) useful for confirmatory testing?: Int Conf AIDS. 1990 Jun 20-23;6(1):199 (abstract no. Th.A.317). Unique Identifier : AIDSLINE ICA6/10031790; Georgopoulou U; Okayama A; Mueller N; Hatzakis A; National Retrovirus Reference Center, Athens University Medical; School, Athens, Greece; OBJECTIVE: To evaluate the sensitivity of different commercially available tests for the detection of antibodies to HTLV-I (anti-HTLV-I). METHODS: Forty serum samples from HTLV-I seropositive carriers from Japan were tested. The samples were previously confirmed by radioimmunoprecip
HTLV, Hepatitis B and C markers in Africans with tuberculosis and AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):199 (abstract no. Th.A.318). Unique Identifier : AIDSLINE ICA6/10031890; Munema J; Williams O; Purcell RH; Wong D; Muhimbili Medical Center, Dar-Es-Salam, Tanzania; OBJECTIVES: To find out primarily the seroprevalence rates of HTLVI and markers of Hepatitis B and C in African patients with tuberculosis and AIDS and secondarily to find out if these are significant cofactors for the progression of HIV infection to the disease, AIDS. METHODS: A cohort of 20 Tanzanian patients with T
RH9 cells exposed to salivary gland extracts from patients with Sjogren's Syndrome produce an A-type particle antigenically-related to HIV.: Int Conf AIDS. 1990 Jun 20-23;6(1):199 (abstract no. Th.A.319). Unique Identifier : AIDSLINE ICA6/10031990; Garry RF; Talal N; Hart DJ; Fermin CD; Alexander SS; Dang H; Tulane School of Medicine, New Orleans, Louisiana, USA; OBJECTIVE: The sera of 30% of Sjogren s Syndrome (SS; autoimmune exocrinopathy) patients (14/47) contain significant levels of antibodies reactive with the major gag protein of HIV (CA, p25). Experiments were designed to identify the antigenic stimulus. METHODS: SS is characterized by infiltration of lymphoid cells in
Monkey blood that serologically cross reacts with HIV-1 antigens contains a provirus that hybridises with HIV-1 probes at low stringency.: Int Conf AIDS. 1990 Jun 20-23;6(1):200 (abstract no. Th.A.320). Unique Identifier : AIDSLINE ICA6/10032090; Kolesnitchenko V; Laaroubi K; Messinger D; Bernard J; Zagury JF; Agius G; Snart RS; Gallo R; Zagury D; Universite Pierre et Marie Curie, Paris, France; OBJECT: To investigate the characteristics of the retroviral infection in the blood of wild cercopithecus monkeys found in central African forests. Wild cercopithecus monkeys trapped in the wild have been anaesthetised, blood samples taken and then immediately released. The blood has been serologically examined using
Autocrine and paracrine growth stimulation of Kaposi's sarcoma-derived cell cultures.: Int Conf AIDS. 1990 Jun 20-23;6(1):200 (abstract no. Th.A.321). Unique Identifier : AIDSLINE ICA6/10032190; Roth WK; Werner S; Hofschneider PH; Max-Planck-Institut fur Biochemie, Martinsried, FRG; OBJECTIVE: In vitro cultivation of Kaposi s sarcoma (KS)-derived cell cultures for studying their grade of malignancy, their growth factor synthesis and growth factor requirements. METHODS: Primary cell culture; malignancy tests; growth assays; conditioned media; thymidine incorporation; northern blotting; receptor bi
Cultured Kaposi's sarcoma-derived spindle cells express vascular permeability inducing activity.: Int Conf AIDS. 1990 Jun 20-23;6(1):200 (abstract no. Th.A.322). Unique Identifier : AIDSLINE ICA6/10032290; Sakurada S; Nakamura S; Salahuddin SZ; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892, USA; OBJECTIVE: To elucidate the mechanism of edema associated with AIDS-Kaposi s sarcoma (AIDS-KS) lesions. METHODS: Long-term cultured AIDS-KS cells and their concentrated culture supernatants were transplanted/injected intraperitoneally and subcutaneously into athymic nude mice following injection of Evans blue at vario
Phenotypic characterization of AIDS-Kaposi's sarcoma cells in long-term culture in the absence of retrovirally conditioned medium.: Int Conf AIDS. 1990 Jun 20-23;6(1):200 (abstract no. Th.A.323). Unique Identifier : AIDSLINE ICA6/10032390; Way D; Witte M; Bernas M; Fiala M; Witte C; Nagle R; Stuntz M; Ramirez G; Milligan M; Department of Surgery, The University of Arizona College of; Medicine, Tucson, AZ; OBJECTIVE: Isolate, propagate, and characterize the specific Kaposi s sarcoma cell. METHODS: Based upon our previously successful techniques for in vitro isolation of endothelium from benign lymphatic and blood vascular tumors, (i.e., lymphangiomas and hemangiomas), we prepared enzyme isolate cultures of excised KS sk
Kaposi's sarcoma and HIV infection in Cameroon.: Int Conf AIDS. 1990 Jun 20-23;6(1):201 (abstract no. Th.A.324). Unique Identifier : AIDSLINE ICA6/10032490; Ossondo Nolm M; Etoundi-Mballa GA; Ndumbe P; Zekeng L; Ngu VA; University Center for Health Sciences in Yaounde (Cameroon); Kaposi s sarcoma is the frequently encountered malignant disease in AIDS, but the reason for this association is not clear. We have studied the association of HIV infection with Kaposi s sarcoma in Cameroon where the latter is relatively common. We tested 30 patients with Kaposi
High prevalence of anal intra-epithelial neoplasia and anal papillomavirus infection among males with group IV HIV disease.: Int Conf AIDS. 1990 Jun 20-23;6(1):201 (abstract no. Th.A.325). Unique Identifier : AIDSLINE ICA6/10032590; Palefsky JM; Gonzales J; Ahn DK; Hollander H; Department of Laboratory Medicine, University of California, San; Francisco, California, USA; OBJECTIVE: Squamous cell cancer of the anus is increasing in incidence among homosexual males and, similar to other human papillomavirus (HPV)-associated cancers such as cervical cancer, the risk may be increased in association with immunodeficiency. The goals of this study were 1) to determine the prevalence of, and
Interaction of human immunodeficiency and papilloma viruses: association with anal epithelial abnormality in homosexual men.: Int Conf AIDS. 1990 Jun 20-23;6(1):201 (abstract no. Th.A.326). Unique Identifier : AIDSLINE ICA6/10032690; Goedert JJ; Caussy D; Palefsky J; Gonzales J; Grossman RJ; DiGioia RJ; Sanchez WC; NCI, Bethesda, MD, USA; OBJECTIVE: To evaluate whether human immunodeficiency virus (HIV) infection enhances the expression of human papilloma virus (HPV) and whether anal epithelial abnormality is related to biologic interaction between HIV and HPV. METHODS: Anal swabs obtained from 105 homosexual men were tested for HPV specific sequences
Significance of retroviral DNA sequences in malignant neoplasia from Africa.: Int Conf AIDS. 1990 Jun 20-23;6(1):201 (abstract no. Th.A.327). Unique Identifier : AIDSLINE ICA6/10032790; Williams O; Mugerwa J; Wamukota W; Owor R; Fogarty International Center, National Institutes of Health,; Bethesda, Maryland, USA; OBJECTIVES: Different seroprevalent rates for HIV1 in Kaposi Sarcoma have been reported from different parts of the world including Africa. It was decided to find out if nucleic acid sequences for HIV or HTLV, structural and non structural genes, can be detected in Kaposi Sarcoma and lymphoproliferative malignant tiss
Immunoglobulin secreted by an AIDS lymphoma cell line recognizes HIV gp160, suggesting that the immune response to HIV antigens may contribute to lymphomagenesis.: Int Conf AIDS. 1990 Jun 20-23;6(1):202 (abstract no. Th.A.328). Unique Identifier : AIDSLINE ICA6/10032890; Ng VL; Fein C; Khayam-Bashi F; Nelson P; Fry K; McGrath MS; University of California, San Francisco, California, USA; OBJECTIVE: To determine the antigenic specificity and nucleic acid sequence of the variable regions of the IgM secreted by 2F7, an AIDS lymphoma cell line. METHODS: Solid phase immunoprecipitation (SPIT), SDS-PAGE, Southern blot, polymerase chain reaction (PCR) amplification of the immunoglobulin mRNA present in 2F7 c
Multisite molecular analysis of AIDS-associated lymphomas.: Int Conf AIDS. 1990 Jun 20-23;6(1):202 (abstract no. Th.A.329). Unique Identifier : AIDSLINE ICA6/10032990; Herndier B; Shiramizu B; Sanchez H; Kaplan L; Meeker T; McGrath M; SFGH, University of California, San Francisco, California, USA; OBJECTIVE: The pathogenesis of AIDS-associated lymphomas is unclear. We sampled multiple sites of 3 autopsies with the express purpose of developing a molecular scheme to characterize B-cell lymphoproliferations and tumors in AIDS patients. METHODS: DNA was isolated from phenotypically characterized autopsy tissue sit
AIDS vaccine development: scientific and public policy challenges for the 1990's.: Int Conf AIDS. 1990 Jun 20-23;6(1):202 (abstract no. Th.A.330). Unique Identifier : AIDSLINE ICA6/10033090; Koff WC; Schultz AM; Mathieson BJ; Detrick B; Glass MJ; Wescott SL; Lawrence DN; Division of AIDS, NIAID, NIH, Bethesda, Maryland, USA; In efforts to expedite the development of a safe and effective AIDS vaccine, two comprehensive programs have been established by the Division of AIDS, NIAID. These programs, known as the AIDS Vaccine Research and Development Group and AIDS Vaccine Clinical Trials Network, consist of international networks of scientist
HIV-1 Tat protein released during acute infection stimulates growth of spindle cells derived from AIDS-Kaposi's sarcoma.: Int Conf AIDS. 1990 Jun 20-23;6(1):202 (abstract no. Th.A.331). Unique Identifier : AIDSLINE ICA6/10033190; Ensoli B; Barillari G; Salahuddin SZ; Gallo RC; Wong-Staal F; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892, USA; HIV-1 Tat protein is released into the culture supernatant during acute infection of H9 cells or by COS-1 cells transfected with a Tat-expressing plasmid. The Tat-containing supernatants specifically stimulate growth of cells derived from Kaposi s sarcoma (KS) lesions of AIDS patients and this proliferative effect is
HIV-specific B and T lymphocyte functions in uninfected human volunteers immunized with HIV recombinant gp160.: Int Conf AIDS. 1990 Jun 20-23;6(1):203 (abstract no. Th.A.332). Unique Identifier : AIDSLINE ICA6/10033290; Clerici M; Tacket CO; Via CS; Berzofsky JA; Shearer GM; National Cancer Institute, Bethesda, Maryland, USA; OBJECTIVE: The purpose of this study was to determine whether immunization of uninfected volunteers with a recombinant gp160 (rgp160) candidate vaccine would result in the production of HIV-specific serum antibodies, and whether peripheral blood leukocytes (PBL) from these donors would generate T cell immune responses
Enhanced immunogenicity in humans of an HIV subunit vaccine regimen employing priming with a vaccinia gp160 recombinant virus (vac/env) by boosting with recombinant HIV envelope glycoprotein (rgp160).: Int Conf AIDS. 1990 Jun 20-23;6(1):203 (abstract no. Th.A.333). Unique Identifier : AIDSLINE ICA6/10033390; Cooney EL; Corey L; Hu SL; Collier A; Arditti D; Hoffman M; Smith G; Steimer K; Greenberg P; University of Washington, Seattle, WA USA; OBJECTIVE: To determine if the T cell and antibody responses to the envelope of HIV can be augmented in individuals previously immunized with a recombinant vaccinia (vac/env) virus [HIVAC-le, Oncogen] by boosting with recombinant gp160 derived from a baculovirus vector and formulated in alum [MicroGeneSys]. METHODS: 1
Study of humoral response from French seronegative healthy immunized volunteers against HIV.: Int Conf AIDS. 1990 Jun 20-23;6(1):203 (abstract no. Th.A.334). Unique Identifier : AIDSLINE ICA6/10033490; Boyer V; Picard O; Mortier M; Zagury D; Desgranges C; INSERM U 271, Lyon, France; OBJECTIVE: To determine the neutralizing or the antibody-dependent enhancing capacity of sera from HIV negative immunized volunteers. METHODS: Sera from 30 immunized volunteers (D. Zagury protocol) were obtained one month after each boost for about one year. These sera were tested in the MT4 neutralizing assay against
Immune therapy: clinical trial (phase 1) in AIDS/ARCS patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):203 (abstract no. Th.A.335). Unique Identifier : AIDSLINE ICA6/10033590; Picard O; Imbert JC; Salaun JJ; Lurhama Z; Moss B; Gallo RC; Zagury D; Hopital Saint Antoine (Paris), France; A clinical trial (Phase 1) against AIDS consisting of active anti HIV specific immunization was begun in March 1989 on 19 ARC/AIDS patients in the Hopital Saint Antoine. In this trial, immunizations administered 4 or 5 times a year were aimed at enhancing HIV immunogenic signals at the surface of antigen presenting ce
The HLA-A11 molecule is CTL restricting for the immunodominant epitope, peptide 18, of HIV gp160 in immunized humans.: Int Conf AIDS. 1990 Jun 20-23;6(1):204 (abstract no. Th.A.336). Unique Identifier : AIDSLINE ICA6/10033690; Achour A; Lamhamedi S; Faure P; Willer A; Berzofsky JA; Gallo RC; Zagury D; Universite Pierre et Marie Curie, France; OBJECTIVE: In a previous report we demonstrated that peptide 18 can be used to detect T effector cell activity and that effector cells are restricted HLA.A2 and HLA.A3. We investigated whether the HLA.A11 is a CTL restricting element for peptide 18 in immunized humans. METHODS: Volunteers primed by rV expressing gp160
Immunization of HIV-infected individuals with inactivated HIV immunogen: significance of HIV-specific cell-mediated immune response.: Int Conf AIDS. 1990 Jun 20-23;6(1):204 (abstract no. Th.A.337). Unique Identifier : AIDSLINE ICA6/10033790; Levine A; Henderson BE; Groshen S; Burnett K; Jensen F; Peters R; Carlo D; Gersten M; Salk J; Univ Southern CA, Los Angeles, CA, USA; OBJECTIVES: To determine the feasibility of therapeutic immunization with an inactivated envelope-depleted HIV immunogen, administered to HIV-seropositive subjects, to delay or prevent progression to AIDS, and to determine the methods whereby a clinically significant immune response may be measured. METHODS: 100 ug do
Experience with thirteen HIV efficacy trials in chimpanzees.: Int Conf AIDS. 1990 Jun 20-23;6(1):204 (abstract no. Th.A.338). Unique Identifier : AIDSLINE ICA6/10033890; Eichberg JW; Southwest Foundation for Biomedical Research, San Antonio, Texas,; USA; OBJECTIVE: To evaluate the efficacy of various HIV vaccines to prevent infection in chimpanzees. METHODS: The following HIV vaccine candidates were employed to actively or passively vaccinate a total of 43 chimpanzees. 1. synthetic peptide (735-752), 2. vaccinia-env, 3. rpg120 (CHO), 4. HIVIG, 5. recombinant peptide (
Anti-HIV antibody-dependent cellular cytotoxicity (ADCC) in sera of immunized chimpanzees.: Int Conf AIDS. 1990 Jun 20-23;6(1):204 (abstract no. Th.A.339). Unique Identifier : AIDSLINE ICA6/10033990; Belo M; Yagello M; Laurent JP; Girard M; Gluckman JC; Cervi, Pitie-Salpetriere Medical School, Paris, France; OBJECTIVE: Antibodies (Ab) that mediate ADCC were investigated in an animal vaccination model because, beside virus neutralization, ADCC may be important to consider for protection against HIV infection. METHODS: Adult chimpanzees received greater than or equal to 3 injections of different combinations of HIV-1 BRU an
Challenge with HIV is not followed by antibody response to viral core proteins in a chimpanzee immunized with recombinant gp160.: Int Conf AIDS. 1990 Jun 20-23;6(1):205 (abstract no. Th.A.340). Unique Identifier : AIDSLINE ICA6/10034090; Mannhalter J; Eibl MM; Dorner F; Moss B; Gallo RC; Eder G; Immuno AG, Vienna, Austria; OBJECTIVE: To test the potency of an HIV candidate vaccine in the chimpanzee model. METHODS: Chimpanzees received 6 intramuscular doses of recombinant gp160 (rgp160, 50mug per immunization) on days 0,27,55,97,120 and 147. On day 315 two rgp160-immunized chimpanzees and one unimmunized control animal were challenged by
Surveillance of AIDS vaccine studies in non-human primates.: Int Conf AIDS. 1990 Jun 20-23;6(1):205 (abstract no. Th.A.341). Unique Identifier : AIDSLINE ICA6/10034190; Schultz AM; Division of AIDS, NIAID, National Institutes of Health, Bethesda,; MD, USA 20892; Animal models are essential to AIDS vaccine development. Simian immunodeficiency virus (SIV) originating from the sooty mangabey infects and causes disease in rhesus macaques. This surrogate model for human AIDS is now well-established and has already produced important vaccine studies. The same SIV growing in cynomol
SIV vaccine protection of rhesus macaques.: Int Conf AIDS. 1990 Jun 20-23;6(1):205 (abstract no. Th.A.342). Unique Identifier : AIDSLINE ICA6/10034290; Gardner MB; McGraw T; Luciw P; Carlson J; Department of Medical Pathology, California Primate Research; Center, University of California, Davis, USA; OBJECTIVE: To determine if rhesus monkeys can be protected against challenge with live SIV by an inactivated whole SIV vaccine. METHODS: Monkeys were immunized with an inactivated whole SIVmac vaccine using two different adjuvants, muramyl dipeptide (MDP) and incomplete Freund s adjuvant (IFA) or no adjuvant. They wer
Immunization with HIV-1 gp160 enhances HIV-specific immune responses elicited by vaccinia-HIV recombinant virus.: Int Conf AIDS. 1990 Jun 20-23;6(1):205 (abstract no. Th.A.343). Unique Identifier : AIDSLINE ICA6/10034390; Hu SL; Klanieki J; Schmitt R; Wain RM; Dykers T; Morein B; Lewis JB; Oncogen, Seattle, WA, USA; OBJECTIVE: To determine if immunization with gp160 could further increase the immune responses elicited by vaccinia-HIV recombinant virus and to study the effect of various adjuvants on the immunogenicity of gp160. METHODS: HIV-1 gp160 was expressed either in insect cells by a baculovirus vector, or in mammalian cells
The efficient expression of simian immunodeficiency virus (SIV) envelope protein from the recombinant human adenovirus type 5 with a host-range mutation.: Int Conf AIDS. 1990 Jun 20-23;6(1):206 (abstract no. Th.A.344). Unique Identifier : AIDSLINE ICA6/10034490; Cheng SM; Ronchetti-Blume M; Hum W; Politis-Virk K; Dheer S; Hirsch V; Johnson P; Mizutani S; Davis A; Lee S; et al; Wyeth-Ayerst Research, Radnor, PA, USA; OBJECTIVE: To express SIV envelope protein from a recombinant adenovirus capable of infecting both human and monkey cells. METHODS: Two recombinant adenoviruses were constructed: (1) pEX017/ad5hr contains a single subgenomic segment of SIV that includes both exons of rev and the entire env gene; (2) pENV9/ad5hr was de
Specific response of rhesus monkeys to an immunization with vaccinia-HIV2 recombinants.: Int Conf AIDS. 1990 Jun 20-23;6(1):206 (abstract no. Th.A.345). Unique Identifier : AIDSLINE ICA6/10034590; Vogt G; Dormont D; Kieny MP; Kaczorek M; Sonigo P; Girard M; SSA/DPS/SPE/CEA, Fontenay aux Roses, France; OBJECTIVE: To study the immunization of Rhesus monkeys, with a mixture of vaccine-HIV2 recombinants, and to determine the usefulness of vaccine env recombinant addition in this potential vaccine preparation against HIV2. METHODS: As a vaccine, we used different recombinant vaccinia viruses expressing HIV2 genes: gag,
Assembly of HIV-like particles by a recombinant vaccinia virus expression system.: Int Conf AIDS. 1990 Jun 20-23;6(1):206 (abstract no. Th.A.346). Unique Identifier : AIDSLINE ICA6/10034690; Haffar O; Garrigues J; Travis B; Moran P; Smithgall M; Zarling J; Hu S; Oncogen Corporation, Seattle, WA, USA; OBJECTIVE: To study the in vitro assembly of defective HIV-1 particles, and their potential use as immunomodulators in the treatment of AIDS. METHODS: BSC-40 cells were infected with two vaccinia recombinant viruses carrying either the HIV-1 gag or env genes. The gag gene used in these experiments included the virus p
Formation of primate lentivirus particles in cells infected with vaccinia recombinants.: Int Conf AIDS. 1990 Jun 20-23;6(1):206 (abstract no. Th.A.347). Unique Identifier : AIDSLINE ICA6/10034790; Panicali D; Mazzara G; Stallard V; Cormier N; Desrosiers N; King N; Applied bioTechnology, Cambridge, MA, USA; OBJECTIVE: To analyze the production of retroviral-like particles by recombinant vaccinia viruses that express the env, gag and pol genes of HIV-1 or of simian immunodeficiency virus (SIV). METHODS AND RESULTS: Recombinant vaccinia viruses containing the env, gag, and pol genes of HIV-1 or of SIVmac251, in monovalent
Expression and processing of HIV gag proteins with recombinant adenovirus vectors.: Int Conf AIDS. 1990 Jun 20-23;6(1):207 (abstract no. Th.A.348). Unique Identifier : AIDSLINE ICA6/10034890; Wilhelm J; Kalyan N; Chanda P; Murthy S; Vernon S; Molnar-Kimber K; Mizutani S; Davis A; Lee S; Hung P; Wyeth-Ayerst Research, P.O. Box 8299, Philadelphia, PA 19101 USA; OBJECTIVE: To explore HIV gag expression by recombinant adenoviruses as part of a broader program in the development of oral HIV vaccines based on adenovirus vectors. METHODS: Non-defective type 4 and 7 adenoviruses (with E3 deletions) were constructed to carry the HIV rev gene in the E3 region and, in the right-hand
Construction of synthetic HIV peptide immunogens using defined T and B-cell epitopes.: Int Conf AIDS. 1990 Jun 20-23;6(1):207 (abstract no. Th.A.349). Unique Identifier : AIDSLINE ICA6/10034990; Sia DY; Chong P; Rovinski B; Haynes J; Klein M; Connaught Centre for Biotechnology Research, 1755 Steeles Avenue; West, Willowdale, Ontario M2R 3T4, Canada; The identification of relevant T and B-cell epitopes on HIV gene products is important for the rational design of an AIDS synthetic vaccine. A highly conserved T-cell epitope of HIV-1 p24, p24E encompassing amino acid residues 292-306 was selected to construct two chimeric peptides, namely CLTB-1 and CLTB-2 which indi
Synthetic peptides from a conserved region of the HIV envelope induce broadly reactive anti-HIV responses.: Int Conf AIDS. 1990 Jun 20-23;6(1):207 (abstract no. Th.A.350). Unique Identifier : AIDSLINE ICA6/10035090; Morrow WJ; Williams WM; Whalley A; Ryskamp T; Newman R; Kang CY; Chamat S; Kohler H; Kieber-Emmons T; IDEC Pharmaceuticals Corp., La Jolla, California, USA; In our efforts to identify reagents that might be used for active immunotherapy in HIV infection, we have studied synthetic peptides derived from the CD4 attachment site of gp120. Two peptides have emerged with particularly interesting properties. The first (B138) spans the envelope residues 421-438 and is a linear fo
Paratope-specific anti-idiotypic antibody (Ab-2) induces HIV-1 neutralizing antibodies in rabbits.: Int Conf AIDS. 1990 Jun 20-23;6(1):207 (abstract no. Th.A.351). Unique Identifier : AIDSLINE ICA6/10035190; Fung M; Sun C; Liou R; Gordon W; Chang N; Chang TW; Sun NC; Tanox Biosystems, Inc., Houston, Texas, USA; OBJECTIVE: Based on the concept of idiotype (Id) network, an HIV-neutralizing monoclonal antibody (BAT123) recognizing the neutralization site of HTLV-IIIB gp120 (amino acid residue No. 308-322) was used to generate syngeneic Ab-2 bearing the internal image of this neutralization site. These paratope-specific Ab-2 (Ab
Preparation of anti-idiotypic antibodies by using synthetic CD4 fragment peptide (70-132) inhibiting HIV-1 replication and syncytium formation.: Int Conf AIDS. 1990 Jun 20-23;6(1):208 (abstract no. Th.A.352). Unique Identifier : AIDSLINE ICA6/10035290; Ohki K; Kimura T; Ohmura K; Ikuta K; Inst. Immunol. Sci., Hokkaido Univ., Sapporo, Japan; OBJECTIVE: We previously reported the identification of CD4 fragment peptide (70-132) that inhibits HIV-1 replication and syncytium formation (1). To prepare anti-idiotypic antibodies by using this CD4 fragment peptide. METHODS: CD4 fragment peptide (70-132) was synthesized chemically on solid phase, and used as an an
Anti-CD4 idiotypes: potential for AIDS vaccination.: Int Conf AIDS. 1990 Jun 20-23;6(1):208 (abstract no. Th.A.353). Unique Identifier : AIDSLINE ICA6/10035390; Buck DW; Schroeder K; Suni M; Kelkenberg J; Estess P; Healey D; Sweet R; Truneh A; Becton Dickinson Monoclonal Center, Mountain View, California,; USA; OBJECTIVE: The production of monoclonal anti-CD4 antibodies which bind to or overlap with the HIV gp120 binding site on CD4. To assess the potential of these Ab-1 antibodies to produce an internal image anti-idiotype (Ab-2) response in small animals, which by structurally mimicking the CD4 receptor, will bind to and n
Generation of monoclonal anti-idiotypic antibodies against a neutralizing monoclonal antibody (0.5beta) of HIV-1.: Int Conf AIDS. 1990 Jun 20-23;6(1):208 (abstract no. Th.A.354). Unique Identifier : AIDSLINE ICA6/10035490; Maeda Y; Matsushita S; Murakami T; Koito A; Hattori T; Takatsuki K; Second Department of Internal Medicine, Kumamoto University; Medical School, Kumamoto, Japan 860; OBJECTIVE: Anti-idiotypic antibodies (Ab2) which recognize unique V region of antigen binding antibody (Ab1) and mimic internal image of antigen could be used for vaccines of some kinds of infectious agents or tumors. In order to apply this strategy for HIV, syngeneic monoclonal anti-idiotypic antibodies directed agai
T4a - specific antibodies imitating the gp120 binding site used for vaccination against HIV.: Int Conf AIDS. 1990 Jun 20-23;6(1):208 (abstract no. Th.A.355). Unique Identifier : AIDSLINE ICA6/10035590; Sutor C; Dreikhausen U; Schedel I; Department of Internal Medicine, Division of Immunology, Medical; School of Hannover F.R. of Germany; OBJECTIVE: Monoclonal antibodies generated against the T4a epitope were shown to block gp120-CD4 interaction and inhibit syncytia formation in HIV infected lymphocyte cultures. These T4a-specific antibodies may serve as a vaccine to raise -via an anti-idiotypic response- antibodies cross-reacting with the gp120 bindin
Autologous and recombinant HIV-1 core particles produced in different eucaryotic expression systems as a vaccine candidate.: Int Conf AIDS. 1990 Jun 20-23;6(1):209 (abstract no. Th.A.356). Unique Identifier : AIDSLINE ICA6/10035690; Wagner R; Fliessbach H; von Brunn A; Deby G; Modrow S; Gelderblom H; Wolf H; Max von Pettenkofer-Institut, Munchen, FRG; OBJECTIVE: Conventional HIV-1 vaccine strategies, based on the external part of the env protein, were till now not found to induce protective immunity. In addition, enhancing antibodies may negatively influence disease progression. Due to the early appearance in infection, the virus core protein seems to be a promisin
Denaturation abolishes CD4 mediated immunosuppressive activity, but not antigenicity of GP120.: Int Conf AIDS. 1990 Jun 20-23;6(1):209 (abstract no. Th.A.357). Unique Identifier : AIDSLINE ICA6/10035790; Manca F; Habeshaw J; Dalgleish AG; Department of Immunology, S. Martino Hospital, 16132 Genoa, Italy; HIV gp120 inhibits antigen dependent T cell activation by binding to CD4, an accessory structure used by T cells to facilitate interaction with MHC on antigen presenting cells (APC). Heat denaturation abolishes immunosuppressive activity (ie. CD4 binding) but spares antigenicity of gp120. This was demonstrated by usin
The immunogenicity of streptococcus pneumoniae (Pn) conjugate vaccines in patients with human immunodeficiency virus (HIV) infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):209 (abstract no. Th.A.358). Unique Identifier : AIDSLINE ICA6/10035890; Lambert JS; Insel R; Weissbach N; Keefer MC; Reid J; Anderson P; University of Rochester Medical Center, Rochester, New York, USA; OBJECTIVE: Pyogenic infections are increasingly recognized to be a major problem in patients at all stages of HIV disease. Patients with AIDS have been shown to have an impaired antibody (Ab) response to Pn capsular polysaccharide (CP) vaccines. The conjugation of CP to carrier proteins is recognized as a method of en
Adoptive transfer of human immune memory responses to Hu-PBL/SCID mice: effect of donor and recipient immunization.: Int Conf AIDS. 1990 Jun 20-23;6(1):209 (abstract no. Th.A.359). Unique Identifier : AIDSLINE ICA6/10035990; Markham RB; Barber JP; Donnenberg AD; Johns Hopkins Medical Institutions, Baltimore, MD, USA; OBJECTIVE: To study the effect of donor and recipient booster immunization on transfer of specific human antibody responses to mice with severe combined immunodeficiency (SCID mice) reconstituted with human peripheral blood cells (Hu-PBL/SCID). METHODS: Groups of 3 (6-8 wk old) SCID mice were transplanted i.p. with 1.
Assessment of HIV 1-p18 antigens on the surface of HIV 1-infected lymphocytes by means of scanning electronmicroscopy.: Int Conf AIDS. 1990 Jun 20-23;6(1):210 (abstract no. Th.A.360). Unique Identifier : AIDSLINE ICA6/10036090; Dennin R; Beyer A; Institut fur Medizinische Mikrobiologie, Medizinische; Universitat; Lubeck, Federal Republic of Germany; OBJECTIVE: This study was designed to look for highly conserved HIV 1-specific antigens expressed on the surface of HIV 1-infected cells with special emphasis to the question whether these antigens are really accessible from outside of the infected cells to cytopathogenic mechanisms like (ADCC). This is to be seen wit
Corticosteroid therapy of idiopathic esophageal ulcers in AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):212 (abstract no. Th.B.361). Unique Identifier : AIDSLINE ICA6/10036190; Borcich A; Reka S; Winkler WP; Kotler DP; St. Luke's-Roosevelt Hospital Center, Columbia P&S, New York, NY,; USA; OBJECTIVE: To determine the effect of corticosteroids upon symptoms in patients with idiopathic esophageal ulcers. METHODS: We previously demonstrated cells containing HIV genome by in situ RNA hybridization in patients with idiopathic esophageal ulcers (Am J Gastroenterol 1989;84:313). Clinical anecdotes indicate tha
Recurrent anogenital warts and HIV status.: Int Conf AIDS. 1990 Jun 20-23;6(1):212 (abstract no. Th.B.362). Unique Identifier : AIDSLINE ICA6/10036290; Thomas G; Geraci A; Lavigne J; Levy M; Affiliation not specified; OBJECTIVE: Recurrence rates of venereal warts have long been felt to be high in those infected with HIV, though no studies of adequate sample size have been published to document this. This study provides statistical evidence for a strong correlation between HIV infection and recurrence of anogenital warts in the gay
Treatment of chronic diarrhea with saccharomyces boulardii.: Int Conf AIDS. 1990 Jun 20-23;6(1):212 (abstract no. Th.B.363). Unique Identifier : AIDSLINE ICA6/10036390; Saint-Marc T; Sellem C; Rosello L; Touraine JL; Pavillon P, Hopital Edouard-Herriot, 69437 Lyon CEDEX 03 France; OBJECTIVE: To assess the response of chronic diarrhea to saccharomyces boulardii. Background: Chronic diarrhea and weight loss are common features of HIV infection and one major course of morbidity and death in HIV infected patients. METHODS: 30 patients with AIDS and severe chronic diarrhea were studied. All patients
Efficacy and tolerance of SMS 201-995 (a somatostatin analogue) in HIV infected patients with diarrhea.: Int Conf AIDS. 1990 Jun 20-23;6(1):213 (abstract no. Th.B.364). Unique Identifier : AIDSLINE ICA6/10036490; Mallolas J; Miro JM; Gatell JM; Moreno A; Soriano E; Infectious Disease Unit. Hospital Clinic. Barcelona. (Spain); OBJECTIVE: To evaluate the clinical efficacy and tolerance of SMS 201-995 as a symptomatic therapy for the diarrhea in HIV infected patients. METHOD: We enrolled all HIV infected patients suffering from diarrhea without clinical response to conventional therapy. SMS 201-995 was administered by subcutaneous route every
Preliminary results of vapreotide (a new somatostatine analogue) in AIDS related diarrhea.: Int Conf AIDS. 1990 Jun 20-23;6(1):213 (abstract no. Th.B.365). Unique Identifier : AIDSLINE ICA6/10036590; Girard PM; Goldschmidt E; Vittecoq D; Massip P; Meyohas MC; Bouslama K; May T; Gallais H; Gastiaburu J; Schally AV; Hopitaux Bichat-C Bernard, Necker, St Antoine, Paris, France; OBJECTIVE: On the basis of experimental antisecretory activity of the somatostatine analog RC-160 (D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH2, Vapreotide) a pilot trial for treatment of AIDS related diarrhea was conducted from August 1988 until December 1989. METHODS AND RESULTS: Twenty-eight patients entered the trial.
Jejunal autonomic neuronal degeneration in human immunodeficiency virus (HIV) infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):213 (abstract no. Th.B.366). Unique Identifier : AIDSLINE ICA6/10036690; Batman P; Miller A; Griffin GE; Department of Histopathology, St. George's Hospital Medical; School, London, UK; OBJECTIVE: Pathophysiology of depressed autonomic nervous function in HIV disease is unknown but may be related to neuronal degeneration. In order to test the hypothesis that jejunal autonomic neuronal mass is reduced in HIV infection we have histologically quantitated neuronal tissue in jejunal biopsies using a neuro
Jejunal biopsy in HIV infected patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):213 (abstract no. Th.B.367). Unique Identifier : AIDSLINE ICA6/10036790; Elia CC; Madi K; Trajman A; Silva CV; Kotze LS; Barroso PF; Universidade Federal do Rio de Janeiro, Brazil; OBJECTIVES: To evaluate the histomorphologic aspects and the presence of microorganisms in the intestinal mucosa, correlating these findings to the clinical stage. PATIENTS AND METHODS: Peroral jejunal biopsy was obtained with a Watson capsule in 43 patients with HIV infection, defined as two positive serologic tests
Diarrhoea in advanced HIV infection associated with increased small intestinal permeability in both African and Caucasian patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):214 (abstract no. Th.B.368). Unique Identifier : AIDSLINE ICA6/10036890; Kapembwa M; Fleming S; Serwadda D; Goodgame R; Lucas S; Sewankambo N; Griffin G; St. George's Hospital, London, UK; OBJECTIVE: To measure small intestinal permeability (SIP) using Lactulose/Mannitol test in Caucasian and African HIV infected patients with and without diarrhoea at different clinical stages of HIV disease. METHODS: 40 London HIV patients (AIDS 26, ARC 7, Asymptomatic 7) 15 of whom had diarrhoea (AIDS 11, ARC 4); 18 n
Intestinal inflammation associated with HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):214 (abstract no. Th.B.369). Unique Identifier : AIDSLINE ICA6/10036990; Reka S; Kotler DP; St Luke's-Roosevelt Hospital Columbia P&S, New York, NY, USA; OBJECTIVE: To correlate the presence of HIV protein expression in the gastrointestinal tract with clinical and histologic features and with tissue cytokine contents. METHODS: Sixty four HIV-infected patients were studied (8 WR2, 9 WR3/4, 10 WR5, 37 WR6 (Walter Reed classification). Rectal biopsies were performed as pa
Helicobacter pylori infection in patients with AIDS or ARC.: Int Conf AIDS. 1990 Jun 20-23;6(1):214 (abstract no. Th.B.370). Unique Identifier : AIDSLINE ICA6/10037090; Battan R; Palagiano A; Raviglione MC; Sabatini MT; Boyle J; Sayad K; Ottaviano L; Cabrini Medical Center, New York, NY, USA; OBJECTIVE: To study the prevalence of Helicobacter (formerly Campylobacter) pylori (HP) infection of the gastric mucosa in unselected patients with AIDS or ARC undergoing endoscopy for upper gastrointestinal complaints. METHODS: On consecutive AIDS/ARC and age-sex matched control patients with similar symptoms 2 endos
Helicobacter pylori infection in HIV+ patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):214 (abstract no. Th.B.371). Unique Identifier : AIDSLINE ICA6/10037190; Bernal A; Rachal L; del Junco G; Piot D; Salvato P; Park Plaza Hospital, Houston, Texas USA; OBJECTIVE: To determine the prevalence and significance of Helicobacter (Campylobacter pylori) infection in HIV-infected patients. METHODS: All patients referred for gastroscopy examination on clinical grounds seen in two consecutive months were included; some of the patients were on antibiotics. Clo test and biopsies
Intestinal spirochetosis of HIV-infected homosexual males.: Int Conf AIDS. 1990 Jun 20-23;6(1):215 (abstract no. Th.B.372). Unique Identifier : AIDSLINE ICA6/10037290; Kasbohrer A; Schneider C; Gelderblom HR; Arasteh K; Heise W; Grosse G; L'age M; Pauli G; AIDS-Zentrum, Berlin, FRG; OBJECTIVE: Prevalence and clinical relevance of intestinal spirochetosis in HIV-positive individuals with enteropathy. METHODS: 42 HIV-infected individuals, 38 of them homosexual males, were studied. 37 showed diarrhea, weight loss, abdominal pain, fever or obstipation as the main symptoms. Biopsies taken by ileocolos
Viral gastrointestinal infection in patients with human immunodeficiency virus (HIV) infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):215 (abstract no. Th.B.373). Unique Identifier : AIDSLINE ICA6/10037390; Rolston K; Rodriguez S; The University of Texas M. D. Anderson Cancer Center, Houston,; Texas, USA; Diarrhea is common in HIV infected individuals and is caused by a wide variety of microorganisms including bacteria, protozoa and other intestinal parasites. Cytomegalovirus ( CMV ) is the most common virus causing diarrhea in such patients. The role of gastrointe
Sialochemistry in HIV-associated salivary gland disease.: Int Conf AIDS. 1990 Jun 20-23;6(1):215 (abstract no. Th.B.374). Unique Identifier : AIDSLINE ICA6/10037490; Schiodt M; Atkinson J; Greenspan D; Fox P; Dodd CL; Daniels TE; Hollander H; Chernoff D; Greenspan JS; Oral AIDS Center, University of California, San Francisco,; California USA; OBJECTIVE: To compare salivary chemistry of HIV-associated salivary gland disease (HIV-SGD) with that in HIV-seropositive controls and primary Sjogren s syndrome(SS). METHODS: HIV-SGD was defined as the presence of xerostomia or enlarged salivary glands in an HIV infected individual. Stimulated parotid saliva was obta
Reliability of negative staining EM for the detection of Epstein Barr virus in oral hairy leukoplakia.: Int Conf AIDS. 1990 Jun 20-23;6(1):215 (abstract no. Th.B.375). Unique Identifier : AIDSLINE ICA6/10037590; Sugihara K; Reichart PA; Gelderblom HR; Pohle HD; Langford A; Schmidt-Westhausen A; Reupke H; Kagoshima University Dental School, Kagoshima, Japan; OBJECTIVE: Purpose of the present study was to evaluate two different EM techniques suitable to detect Epstein-Barr virus (EBV) in oral hairy leukoplakia (HL). METHODS: A comparative study using the conventional two step method of negative staining (CNS) and negative staining after airfuge enrichment (ANS) was perform
Prevalence of hairy leukoplakia by CD4 count level.: Int Conf AIDS. 1990 Jun 20-23;6(1):216 (abstract no. Th.B.376). Unique Identifier : AIDSLINE ICA6/10037690; Feigal DW; Greenspan D; Winkelstein W; Rutherford G; Moss A; Greenspan JS; Univ of Calif, San Diego, CA, USA; OBJECTIVE: To determine prevalence of hairy leukoplakia (HL) by absolute CD4 count in gay men. METHODS: 564 seropositive and 644 seronegative gay men were examined (blind to serostatus) in 1987 in 3 cohorts of the Oral AIDS Epidemiology project: the SF Gay Mens Health Study (SFGMHS, n=715); the SF City Clinic Cohort (
Hairy leukoplakia like lesions in patients without HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):216 (abstract no. Th.B.377). Unique Identifier : AIDSLINE ICA6/10037790; Epstein JB; Sherlock CS; Greenspan JS; Cancer Control Agency of B.C., Vancouver, B.C., Canada; OBJECTIVE: To investigate the role of immunosuppression other than that caused by HIV infection in the pathogenesis of hairy leukoplakia (HL). METHODS: We chose patients at Day 90-100 following bone marrow transplant as models of chronic severe immunosuppression. All patients were HIV negative. Clinical changes of the
Molecular typing of Candida albicans isolated from oral lesions of HIV-infected individuals.: Int Conf AIDS. 1990 Jun 20-23;6(1):216 (abstract no. Th.B.378). Unique Identifier : AIDSLINE ICA6/10037890; Powderly W; Robinson K; Keath EJ; Div. of Infectious Diseases, VA Medical Center and Washington; University, St. Louis, MO, USA; OBJECTIVE: Clonal restriction (i.e. infection limited to one or more unique strains) has recently been described for Mycobacterium avium-intracellulare complex and Histoplasma capsulatum infection in patients with AIDS. It has also been suggested, based on serotypic analysis, that strains of Candida albicans are simil
Oral lesions in children with HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):216 (abstract no. Th.B.379). Unique Identifier : AIDSLINE ICA6/10037990; Leggott PJ; Mastrucci MT; MacPhail L; Weintrub PS; Rumsey CL; Cowan MJ; Scott GB; Greenspan JS; University of British Columbia, Canada; OBJECTIVE: To investigate the nature and prevalence of oral lesions in children born to HIV infected mothers. METHODS: Two cohorts of children are being followed as part of a longitudinal study of the epidemiology of oral manifestations of HIV infection in children. A hundred seropositive children with perinatally acq
Oral pathology is a good predictor for HIV infection in high risk population.: Int Conf AIDS. 1990 Jun 20-23;6(1):217 (abstract no. Th.B.380). Unique Identifier : AIDSLINE ICA6/10038090; Casariego Z; Cahn P; Perez H; Casiro A; Muchinik G; Rickard E; Htal Fernandez, Buenos Aires, Argentina; OBJECTIVE: To study the value of oral pathology as a predictor of HIV sero positivity in high risk populations. METHODS: In 303 patients (pts) who consulted spontaneously for first time to our HIV clinic, we performed clinical and stomatological examination. Oral pathology was defined as one or more of the following:
Oral mucosal lymphomas in AIDS patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):217 (abstract no. Th.B.381). Unique Identifier : AIDSLINE ICA6/10038190; Raphael M; Pallesen G; Chomette G; Audouin J; Szpirglas H; Hamilton-Dutoit S; Lenoir G; CHU Pitie-Salpetriere, Paris, France; Extra-nodal sites with unusual presentation of high grade non-Hodgkin s lymphomas (NHL) of Bcell type are observed in AIDS patients. We report a series of 12 patients with oral mucosal lymphomas registered in the French study group for HIV associated tumors and in the Danish group. Twelve patients (mean age: 39 year o
Aphthous ulcers associated with HIV-disease: relationship of T4 and T8 counts to type of ulcer.: Int Conf AIDS. 1990 Jun 20-23;6(1):217 (abstract no. Th.B.382). Unique Identifier : AIDSLINE ICA6/10038290; MacPhail LA; Greenspan D; Feigal DW; Lennette ET; Dodd C; Schiodt M; Greenspan JS; Oral AIDS Center, Univ of Calif., San Francisco, CA, USA; OBJECTIVE: To determine the relationship between lymphocyte subtype and HIV associated recurrent aphthous ulcers (RAU). METHODS: Absolute T4 and T8 counts were determined in 42 patients on 124 visits for RAU. RAU types were defined as: Minor = 1 or more ulcers less than 10 mm diameter, Major = 1 or more greater than 1
Longitudinal observation of HIV-associated gingivitis.: Int Conf AIDS. 1990 Jun 20-23;6(1):217 (abstract no. Th.B.383). Unique Identifier : AIDSLINE ICA6/10038390; Grassi M; Hammerle C; Staschek I; Berthold H; Lang NP; University of Bern, Bern, Switzerland, School of Dental Medicine; OBJECTIVE: The purpose of the present investigation is to study longitudinally the severity and the course of HIV-associated gingivitis by standard clinical periodontal parameters. METHODS: 12 patients were selected for this study, 10 males and 2 females with a mean age of 33.2 years (range from 22 to 48). Six patient
Fluconazole in maintenance therapy of oral candidiasis in HIV infected adults.: Int Conf AIDS. 1990 Jun 20-23;6(1):218 (abstract no. Th.B.384). Unique Identifier : AIDSLINE ICA6/10038490; Reynes J; Azay J; Montes B; Mallie M; Janbon F; Bertrand A; (Infectious Diseases Unit) University of Montpellier,; Montpellier, France; OBJECTIVE: To evaluate efficacy and tolerance of oral fluconazole in maintenance therapy after a first oral candidiasis episode. METHODS: 53 HIV infected adults (12 ARC, 41 AIDS), after an initial curative treatment of fluconazole (50 mg daily for 2-4 weeks), received oral fluconazole (50 mg daily for one week in two)
Fluconazole or clotrimazole troche for oropharyngeal candidiasis in HIV-1 positive patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):218 (abstract no. Th.B.385). Unique Identifier : AIDSLINE ICA6/10038590; Lichter S; Palenicek J; Yamaguchi E; Barbacci M; Chaisson RE; The Johns Hopkins University School of Medicine, Baltimore,; Maryland, USA; OBJECTIVE: Study the efficacy, safety and tolerance of fluconazole or clotrimazole troches in the treatment of HIV-1 positive patients with oropharyngeal candidiasis. METHODS: Patients with symptomatic, culture-proven oral candidiasis were randomized to fluconazole daily capsule (100 mg) or clotrimazole troche five ti
The role of tumor necrosis factor (TNF) and altered metabolic rate in weight loss in AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):218 (abstract no. Th.B.386). Unique Identifier : AIDSLINE ICA6/10038690; Dworkin BM; Seaton T; Wormser G; New York Medical College, Valhalla, N.Y., USA; Patients infected with Human Immunodeficiency Virus (HIV) frequently become cachectic. To evaluate the roles of TNF and hypermetabolism in seropositive HIV patients, we studied 33 clinically stable, afebrile outpatients, staged by CDC criteria as stage 4 (N=33). Resting metabolic rate (RMR) was measured by indirect ca
Supplemental parenteral nutrition in patients with AIDS and protein-calorie malnutrition.: Int Conf AIDS. 1990 Jun 20-23;6(1):218 (abstract no. Th.B.387). Unique Identifier : AIDSLINE ICA6/10038790; Cimoch PJ; Friedberg G; Jackowski J; Reiter WM; Center for Special Immunology, Ft. Lauderdale, Florida, USA; OBJECTIVES: 1. To assess the efficacy of supplemental parenteral nutrition in the treatment of protein-calorie malnutrition not improved by at least 4 weeks of oral supplementation in patients with AIDS. 2. To assess the effect of treatment on performance status and quality of life. 3. To assess infectious and metabol
Dermatological findings in patients with advanced HIV-related disease in Brazil.: Int Conf AIDS. 1990 Jun 20-23;6(1):219 (abstract no. Th.B.388). Unique Identifier : AIDSLINE ICA6/10038890; Manela-Azulay M; Caneschi JR; Cavalcanti M; Ramos-Filho CF; Perez M; Schechter M; Pereira AC Jr; AIDS Programme, Federal University of Rio de Janeiro, Brazil; OBJECTIVE: To describe and evaluate the frequency of dermatological manifestations among patients admitted to a Brazilian University hospital with advanced HIV-related disease. METHODS: Three hundred and fifty consecutive patients were prospectively screened for skin disease. Data was collected for age, sex, ethnicity
Mucocutaneous manifestations of HIV in children and their correlation with immunosuppression.: Int Conf AIDS. 1990 Jun 20-23;6(1):219 (abstract no. Th.B.389). Unique Identifier : AIDSLINE ICA6/10038990; Co M; Sadick N; Ravipati M; Kaplan E; Pahwa S; North Shore University Hospital-Cornell University Medical; College, Manhasset, N.Y., USA; OBJECTIVE: To evaluate the incidence of mucocutaneous disease in children with HIV infection and correlate this with the degree of immunosuppression. METHODS: 76 children, age range 2 wks to 17 yrs 48 of whom were in the P1/P2 and 28 in the P-O category were evaluated for the presence of mucocutaneous disease over a p
Hyperpigmented erythrodermias in AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):219 (abstract no. Th.B.390). Unique Identifier : AIDSLINE ICA6/10039090; Picard C; Matheron S; Salmon D; Raphael M; Crickx B; Belaich S; Bichat-Claude-Bernard Hospital, Paris, France; OBJECTIVE: To describe three case reports of hyperpigmented erythrodermia (E) recorded between July 1987 and December 1989. METHODS: Retrospective study of three HIV1 seropositive patients: 2 homosexual men (1) and (2), and 1 woman (3) (infected by transfusion), respectively: 40, 54 and 82 years old, with no past hist
Seborrhoeic dermatitis (SD) and Pityrosporon ovale (PO) colonisation of the skin in HIV(+) patients and HIV(-) controls.: Int Conf AIDS. 1990 Jun 20-23;6(1):219 (abstract no. Th.B.391). Unique Identifier : AIDSLINE ICA6/10039190; Vandenbruaene M; Colebunders R; Goeman J; Goilav C; Peeters M; De Vroey C; Institute of Tropical Medicine, Antwerp, Belgium; OBJECTIVE: To study the relation between skin colonisation by Pityrosporon ovale (PO) and the presence of seborrhoeic dermatitis (SD) in HIV(+) patients. METHODS: Contact plates (Dixons medium with 0,5 mg/ml chloramphenicol) were pressed on the forehead (FH) and on the intrascapular region (IS) of 32 HIV(+) patients (
Is Pneumocystis carinii (PC) transmissible from AIDS to other patients: a case-control study of a cluster of PC pneumonia in renal transplant recipients.: Int Conf AIDS. 1990 Jun 20-23;6(1):220 (abstract no. Th.B.392). Unique Identifier : AIDSLINE ICA6/10039290; Chave JP; David S; Wauters JP; Glauser MP; Francioli P; Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; OBJECTIVE: Pc pneumonia (pcp) presumably results from reactivation of a previously acquired infection, but clusters of cases in the pre-AIDS era suggest that nosocomial transmission could occur. Since 1988, 4 pcp occurred in HIV-negative renal transplant recipients (rtr), while no cases were observed previously among
Detection of Pneumocystis carinii antigen in bronchoalveolar lavage (BAL) by dot immunobinding assay (DIB).: Int Conf AIDS. 1990 Jun 20-23;6(1):220 (abstract no. Th.B.393). Unique Identifier : AIDSLINE ICA6/10039390; Contini C; Cignarella L; Romani R; Ajassa C; Zamora C; Delia S; Institute of Infectious Diseases, University La Sapienza Rome,; Italy; OBJECTIVE: DIB using non-commercial mouse monoclonal antibody (E5-8) has been compared to an indirect immunofluorescent test (IIF) for detection of P.carinii antigen in BAL. BAL were also stained by Gomori s modified methenamine silver stain (GMS). METHODS: 84 BAL were included in this study: Group A) 40 from AIDS pat
Systemic and alveolar production of interleukin 6 in HIV patients with Pneumocystis carinii pneumonia (PCP).: Int Conf AIDS. 1990 Jun 20-23;6(1):220 (abstract no. Th.B.394). Unique Identifier : AIDSLINE ICA6/10039490; Goujard C; Delfraissy JF; Wallon C; Boue F; Dormont J; Galanaud P; Service de Medecine Interne-INSERM U 131-Hopital; A.Beclere-Clamart-92141. France.; OBJECTIVE: Interleukin 6 (IL6) is likely to be an important mediator of the inflammatory response. In vitro, HIV can induce the secretion of IL6. We have measured the levels of this cytokine by a biological assay in the sera of 76 HIV seropositive patients. METHODS AND RESULTS: The presence of IL6 was considered to be
Aerosolized pentamidine vs. trimethoprim/sulfamethoxazole for acute Pneumcoystis carinii pneumonia (PCP): a randomized double blind trial.: Int Conf AIDS. 1990 Jun 20-23;6(1):220 (abstract no. Th.B.395). Unique Identifier : AIDSLINE ICA6/10039590; Montgomery AB; Edison RE; Sattler F; Hopewell P; Mason G; Feigal DW; Univ of Calif., San Francisco, CA, USA; OBJECTIVE: To assess the efficacy and safety of aerosolized pentamidine (AP) compared to Trimethoprim/Sulfamethoxazole (TMP/SMX) for acute treatment of PCP. METHODS: 379 patients at 27 centers were randomized to AP or TMP/SMX if their room air Aa gradient was less than 55. 284 had PCP microscopically confirmed after i
Clindamycin/primaquine vs trimethoprim/sulfamethoxazole for Pneumocystis carinii pneumonia (PCP) in AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):221 (abstract no. Th.B.396). Unique Identifier : AIDSLINE ICA6/10039690; Toma E; Fournier S; Morisset R; Bolduc P; Marechal C; Hotel-Dieu de Montreal and Universite de Montreal, Montreal,; Que., Canada; OBJECTIVE: To assess the safety and efficacy of clindamycin + primaquine (C/P) in comparison with trimethoprim + sulfamethoxazole (T/S) for the therapy of PCP in patients with AIDS. METHODS: This is an ongoing, double-blind trial which will include 120 patients. Patients are considered if: they are HIV+, have a first
Efficacy of clindamycin/primaquine (C/P) vs trimethoprim/sulfamethoxazole (TMP/SMZ) in acute treatment of Pneumocystis carinii pneumonia (PCP).: Int Conf AIDS. 1990 Jun 20-23;6(1):221 (abstract no. Th.B.397). Unique Identifier : AIDSLINE ICA6/10039790; Ruf B; Rohde I; Pohle HD; II. Department of Internal Medicine, Rudolf Virchow University; Hospital (Wedding), Berlin, FRG; OBJECTIVE: TMP/SMZ is highly effective in PCP treatment but associated with a high rate of side effects. Therefore alternative regimens are needed. The goal of the study was to compare C/P and TMP/SMZ in acute treatment of PCP. PATIENTS: Less or moderate severe cases were included in the C/P study, defined by the foll
Eflornithine versus co-trimoxazole in the treatment of Pneumocystis carinii pneumonia.: Int Conf AIDS. 1990 Jun 20-23;6(1):221 (abstract no. Th.B.398). Unique Identifier : AIDSLINE ICA6/10039890; Smith D; Smithson J; Harding I; Gazzard B; Nelson M; Westminster Hospital, London, England; OBJECTIVE: To assess the efficacy and safety of eflornithine (DFMO) and co-trimoxazole (CTX) in the treatment of first episode Pneumocystis carinii pneumonia (PCP) in AIDS patients. METHODS: Forty five HIV positive patients with cough, exertional dyspnoea, fever and an arterial blood gas (PAo2) less than 11Kpa and a d
A pilot study of piritrexim (PTX) with leucovorin (LCV) for the treatment of pneumocystis pneumonia.: Int Conf AIDS. 1990 Jun 20-23;6(1):221 (abstract no. Th.B.399). Unique Identifier : AIDSLINE ICA6/10039990; Falloon J; Kovacs J; Allegra C; O'Neill D; Tuazon C; Frame P; Dohn M; Joseph P; Feuerstein I; LaFon S; et al; National Institutes of Health, Bethesda, MD, USA; OBJECTIVE: To evaluate the safety and efficacy of oral piritrexim administered with concomitant leucovorin for the treatment of pneumocystis pneumonia (PCP) in AIDS pts. METHODS: An open dose-escalation trial of PTX/LCV was conducted in 4 centers. 23 pts with mild/moderate PCP and no other therapy for this episode rec
Evaluation of pharmacokinetic interactions between the combination of primaquine plus clindamycin and zidovudine (ZDV).: Int Conf AIDS. 1990 Jun 20-23;6(1):222 (abstract no. Th.B.400). Unique Identifier : AIDSLINE ICA6/10040090; Jones DR; Black JR; Indiana University School of Medicine, Indianapolis, IN USA; Agents for prophylaxis of Pneumocystis carinii pneumonia (PCP) cheaper than aerosolized pentamidine and less toxic than trimethoprim/sulfamethoxazole (TMP/SX) are desirable. The combination of clindamycin (C) and primaquine (P) shows comparable activity to TMP/SX in both rat treatment and prophylaxis models of PCP. Pi
Successful out-patient treatment of Pneumocystis carinii pneumonia (PCP) in AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):222 (abstract no. Th.B.401). Unique Identifier : AIDSLINE ICA6/10040190; Falutz J; Tsoukas CM; Sampalis J; Grover S; Montreal General Hospital, Montreal, Canada; OBJECTIVE: Recent improvements in the management of acute PCP have resulted in fewer hospital admissions for treatment. To determine the effectiveness of out-patient (out-pt) management, we analyzed clinical and laboratory characteristics, and outcomes, in acute PCP treated at home or in hospital. METHODS: All first P
Prognostic value of collagenic markers in severe Pneumocystis carinii pneumonia (PCP).: Int Conf AIDS. 1990 Jun 20-23;6(1):222 (abstract no. Th.B.402). Unique Identifier : AIDSLINE ICA6/10040290; Capella F; Guidet B; Farjanel J; Hartman D; Meyohas MC; Offenstadt G; Hop. Saint Antoine, Paris, France; During PCP acute respiratory failure, an irreversible fibrotic process can occur extremely fast. It would be of great interest to have an vivo index predicting the likelihood of such a process. We report here for the first time a study of four markers of collagen metabolism obtained from both bronchoalveolar lavage (B
Unrelated parasitical and clinical data during evolution of Pneumocystis carinii pneumonia (P.C.P.) in AIDS patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):222 (abstract no. Th.B.403). Unique Identifier : AIDSLINE ICA6/10040390; Roux P; Parrot A; Parquin F; Denis M; Akoun G; Mayaud C; Laboratory of parasitology. Tenon Hospital, Paris, France; OBJECTIVE OF THIS STUDY: To determine in AIDS patients (pts) if there is a relation between parasitical data (degree of parasitism (DP) and parasite viability (PV)) and clinical data during the evolution of P.C.P. PATIENTS: This study concerns 61 AIDS pts with P.C.P. diagnosed by bronchoalveolar lavage (BAL) (n=59) or
Correlation of cyst density with mortality in AIDS patients with Pneumocystis carinii pneumonia (PcP).: Int Conf AIDS. 1990 Jun 20-23;6(1):223 (abstract no. Th.B.404). Unique Identifier : AIDSLINE ICA6/10040490; Blumenfeld W; Mayall B; Griffiss M; University of California, San Francisco, CA. USA; 15-20% of AIDS patients with PcP do poorly despite early intervention, but it is not known what distinguishes those who die. We tested the hypothesis that the trophozoite is the more virulent lifeform and therefore more abundant in patients who die, by using image analysis to find out the relative abundance of cysts w
Changing outcome of mechanically ventilated acute respiratory failure secondary to AIDS-related PCP.: Int Conf AIDS. 1990 Jun 20-23;6(1):223 (abstract no. Th.B.405). Unique Identifier : AIDSLINE ICA6/10040590; McGladrey J; Ronco JJ; Russell JA; Lawson LM; MacNeil N; Schechter MT; Ruedy J; Montaner JS; Research Program and Respiratory Division, Department of; Medicine, St. Paul's Hospital, University of British Columbia,; Canada; OBJECTIVE: To describe the outcome of acute respiratory failure (ARF) requiring mechanical ventilation (MV) in the setting of AIDS-related PCP. METHODS: All cases of PCP admitted to our hospital were identified from the AIDS Care Group, PCP Registry. Charts were reviewed to determine the number of cases developing ARF
A randomized, prospective, controlled, and comparative trial of inhaled pentamidine for primary prophylaxis of Pneumocystis carinii pneumonia (PCP).: Int Conf AIDS. 1990 Jun 20-23;6(1):223 (abstract no. Th.B.406). Unique Identifier : AIDSLINE ICA6/10040690; Chopard P; Hirschel B; Lazzarin A; Division of Infectious Diseases, Geneva University Hospital,; Geneva, Switzerland; OBJECTIVE: To determine efficacy and side effects of inhaled pentamidine in the primary prevention of PCP. METHODS: Patients with AIDS but without PCP, patients with advanced Aids-Related-Complex (ARC), and asymptomatic HIV-seropositive persons with less than 200 CD4-positive lymphocytes/mm3 were randomized to one of
Randomized trial of intermittent dapsone versus aerosolized pentamidine for primary and secondary prophylaxis of Pneumocystis carinii pneumonia (PCP).: Int Conf AIDS. 1990 Jun 20-23;6(1):223 (abstract no. Th.B.407). Unique Identifier : AIDSLINE ICA6/10040790; Torres R; Thorn M; Newlands J; Ortiz P; Martin M; Chanin E; Altholz J; Thornton J; St. Vincent's Hospital and Medical Center, New York, N.Y., USA; OBJECTIVE: To compare the efficacy and safety of oral Dapsone (OD) and aerosolized Pentamidine (AP) in the primary and secondary prophylaxis of PCP, and to study the independent effects of prophylaxis and zidovudine (ZDV) on survival in patients with AIDS and ARC. METHODS: 251 patients at risk for PCP were randomized
Aerosolized pentamidine in the prophylaxis of primary and secondary Pneumocystis carinii pneumonia (PCP).: Int Conf AIDS. 1990 Jun 20-23;6(1):224 (abstract no. Th.B.408). Unique Identifier : AIDSLINE ICA6/10040890; Chan C; Rachlis A; Walmsley S; Varga B; Bast M; Phillips A; Ferro S; University of Toronto, Toronto, Ontario, Canada; OBJECTIVE: To evaluate the efficacy of aerosolized pentamidine prophylaxis (APP) for PCP in HIV infected patients. METHOD: From May 1 to December 31, 1989 550 HIV patients were enrolled in an APP treatment program at the central clinic in Toronto. All patients had baseline clinical assessments and pulmonary evaluation
An open, randomised, prospective comparison of oral dapsone and nebulised pentamidine for PCP prophylaxis.: Int Conf AIDS. 1990 Jun 20-23;6(1):224 (abstract no. Th.B.409). Unique Identifier : AIDSLINE ICA6/10040990; Slavin M; Hoy JF; Mijch AM; Sandland AM; Stewart K; Lucas CR; Fairfield Hospital, Melbourne, Australia; OBJECTIVE: To compare the efficacy and haematologic toxicity of oral dapsone and nebulised pentamidine used as PCP prophylaxis in patients also receiving zidovudine ( AZT ). METHOD: HIV patients with CD4 cells of less than 200/ul are randomised to recei
The effect of inhaled pentamidine on alveolar macrophage populations.: Int Conf AIDS. 1990 Jun 20-23;6(1):224 (abstract no. Th.B.410). Unique Identifier : AIDSLINE ICA6/10041090; Johnson MA; Squire SB; Condez A; Poulter LW; Royal Free Hospital and School of Medicine, London, England; OBJECTIVE: This study examines the role of lung macrophage populations in the development of pneumocystis carinii pneumonia (PCP) and the effect of prophylactic inhaled pentamidine on these populations. METHOD: Bronchoalveolar lavage (BAL) was performed on 40 HIV infected patients presenting with pneumonitis. Cytospin
The safety of weekly dapsone and weekly dapsone + pyrimethamine as pneumocystis prophylaxis.: Int Conf AIDS. 1990 Jun 20-23;6(1):224 (abstract no. Th.B.411). Unique Identifier : AIDSLINE ICA6/10041190; Ogata-Arakaki D; Falloon J; Lavelle J; Byrne A; Kovacs J; Pierce P; Davey R; Polis M; Lane HC; Zunich K; et al; Clinical Center/NIAID, National Institutes of Health, Bethesda,; Maryland, USA; OBJECTIVE: To determine the safety of weekly dapsone (dap) and dap plus pyrimethamine (pyr) in individuals with HIV infection who are at risk of P. carinii pneumonia (PCP). METHODS: Pts infected with HIV who had a history of PCP and/or a CD4 count less than 250/mm3 were sequentially enrolled in cohorts receiving dap p
Sulfamethoxazole-trimethoprim as secondary prophylaxis against PCP.: Int Conf AIDS. 1990 Jun 20-23;6(1):225 (abstract no. Th.B.412). Unique Identifier : AIDSLINE ICA6/10041290; Nielsen TL; Jensen BN; Nelsing S; Pedersen C; Orholm M; Skinh:oj P; Mathiesen L; Dept of Infect Dis, University Hospital, Hvidovre, Denmark; OBJECTIVE: To evaluate: 1) the efficacy of sulfamethoxazole trimethoprim (SMX-TMP) as secondary prophylaxis (SP) after Pneumocystis carinii pneumonia (PCP) and 2) the frequency of hypersensitivity reactions during SP. METHODS: One hundred and twenty-two patients received SMX-TMP as SP 800/160 mg daily. Six patients we
Once daily trimethoprim-sulfamethoxazole as prophylaxis for Pneumocystis carinii pneumonia.: Int Conf AIDS. 1990 Jun 20-23;6(1):225 (abstract no. Th.B.413). Unique Identifier : AIDSLINE ICA6/10041390; Kelly J; Keyes C; Marte C; Wolbert J; Chieffe R; Bellevue Hospital/Community Health Project, New York, New York,; USA; OBJECTIVE: To determine the efficacy and hematologic toxicity of once daily (OD) trimethoprim-sulfamethoxazole (TMP/SMX) used as a prophylaxis for Pneumocystis carinii pneumonia (PCP). METHODS: Charts were reviewed retrospectively. Inclusion criteria were (a) PCP prophylaxis with OD TMP/SMX, (b) CD4+ count less than o
Twice weekly dapsone-pyrimethamine for preventing P.Carinii pneumonia relapses in HIV infected patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):225 (abstract no. Th.B.414). Unique Identifier : AIDSLINE ICA6/10041490; Clotet B; Sirera G; Romeu J; Velasco P; Gimeno JM; Tor J; Infectious Diseases Unit. Hospital de Badalona Germans Trias i; Pujol. Spain; OBJECTIVE: This study aimed to evaluate the efficacy of dapsone-pyrimethamine (D-P) in reducing the frequency of second episodes of P.Carinii pneumonia (PCP) in HIV seropositive patients. METHODS: We introduced 20 male patients fulfilling AIDS criteria who had recovered from PCP with intravenous cotrimoxazole therapy
Aerosolised pentamidine (AP). Which nebuliser?: Int Conf AIDS. 1990 Jun 20-23;6(1):225 (abstract no. Th.B.415). Unique Identifier : AIDSLINE ICA6/10041590; Thomas S; O'Doherty M; Page C; Bradbeer C; Nunan T; Bateman N; St. Thomas' Hospital, London SE1 7EH, UK; OBJECTIVE: To measure pulmonary deposition (PD) of AP 300 mg given via Respirgard II and 6 other nebulisers. METHODS: After pre-treatment with salbutamol, 8 patients with AIDS received 300 mg AP (an effective dose for prophylaxis), via 4 jet (Respirgard II [RII], Centimist [C], System 22 Mizer [SM], and System 22 Mize
Distribution of pentamidine (PM) after intravenous and inhaled application in AIDS-patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):226 (abstract no. Th.B.416). Unique Identifier : AIDSLINE ICA6/10041690; Vohringer HF; Arasteh K; Hardtmann E; Auguste-Viktoria-Hospital, Free University of Berlin, FRG; OBJECTIVE: Evaluation of distribution and multiple dose kinetic of PM after intravenous (i.v.) and inhaled application in treatment of pneumocystosis (PCP). METHODS: 35 AIDS-patients (pts) with severe or mild episodes of PCP were treated with PM-isethionate: 8 pts (gr.I) by i.v. infusion (4 mg/kg/day), 11 pts (gr.II)
Scintigraphic evaluation of the lung delivery of three nebulizers used for pentamidine inhalation.: Int Conf AIDS. 1990 Jun 20-23;6(1):226 (abstract no. Th.B.417). Unique Identifier : AIDSLINE ICA6/10041790; Paycha F; Lepretre A; Girard PM; Meulemans A; Russ G; Coulaud JP; Departement de Medecine Nucleaire et des Maladies; Infectieuses, INSERM U13, Hopital Bichat-Claude Bernard, Paris,; France; OBJECTIVE: To evaluate the comparative efficacy of three nebulizers for lung deposition of pentamidine. METHODS: Pentamidine isethionate (150 mg), mixed with technetium-99m-labeled human serum albumin was administered by means of one jet nebulizer (Respirgard, Marquest) and two ultrasonic nebulizers (DP 100, DP Medica
Autoradiographic examination of the organ distribution of 14C-labelled pentamidine in rats after I.V. and inhalative administration.: Int Conf AIDS. 1990 Jun 20-23;6(1):226 (abstract no. Th.B.418). Unique Identifier : AIDSLINE ICA6/10041890; Wingen F; Bragas B; Clinical Research Dpt., Rhone-Poulenc Koln, FRG; OBJECTIVE: The organ distribution of 14C-pentamidine was studied in Sprague Dawley rats by means of whole-body autoradiography following intravenous application and inhalation of aerosolized pentamidine. METHODS: The distribution time after intravenous administration of 5 mg pentamidine per kg rat was 30 minutes, 6 ho
Risk of TB transmission in HIV infected patients receiving aerosolized pentamidine treatment.: Int Conf AIDS. 1990 Jun 20-23;6(1):226 (abstract no. Th.B.419). Unique Identifier : AIDSLINE ICA6/10041990; Leoung G; Schecter G; Kandal K; Freeman E; Corkery K; Wardlaw L; University of California, San Francisco (SFGH), California, USA; OBJECTIVE: Because cough and bronchospasm are frequent side effects of aerosolized pentamidine (AP) treatments, airborne transmission of infectious diseases is a growing concern. TB occurs in 2-5% of all AIDS patients and may represent the most serious threat of nosocomial transmission. This study assessed the risk of
Aerosolized pentamidine induced bronchospasm: relation to airway hyperresponsiveness and response to preventive therapy.: Int Conf AIDS. 1990 Jun 20-23;6(1):227 (abstract no. Th.B.420). Unique Identifier : AIDSLINE ICA6/10042090; Quieffin J; Hunter J; Pare PD; Schechter MT; Ruedy J; Montaner JS; AIDS Research Program and Respiratory Division, Department of; Medicine, St. Paul's Hospital, University of British Columbia,; Vancouver, BC., Canada; OBJECTIVE: To describe the frequency of pentamidine induced bronchospasm (PIB), its relationship to airways hyperresponsiveness and its response to preventive therapy using salbutamol (SAL), ipratropium bromide (IB) or sodium chromoglycate (SC). METHODS: Consecutive patients entering our aerosolized pentamidine (AP) p
Bronchoconstriction induced by nebulized pentamidine. Severity, duration, and reversibility with terbutaline.: Int Conf AIDS. 1990 Jun 20-23;6(1):227 (abstract no. Th.B.421). Unique Identifier : AIDSLINE ICA6/10042190; Leigh T; Wiggins J; Gazzard BG; Collins JV; Westminster Hospital, London, England, UK; OBJECTIVE: To define the extent, duration, and reversibility of Pentamidine induced bronchoconstriction in HIV positive patients, which has so far been poorly characterized. METHODS: Forty males with normal lung function, mean age =35.6, (range 24-56), were studied. All were receiving fortnightly nebulized Pentamidine
Diabetes mellitus in HIV+ patients post-pneumocystis pneumonia and the impact of aerosolized pentamidine.: Int Conf AIDS. 1990 Jun 20-23;6(1):227 (abstract no. Th.B.422). Unique Identifier : AIDSLINE ICA6/10042290; Waskin H; Hardy WD; McClain N; Fall H; Duke Medical Center, Durham, North Carolina, USA; OBJECTIVE: To prospectively monitor post-PCP patients for glucose dysfunction and to identify the risk of dysglycemia in patients who subsequently receive aerosolized pentamidine (AP) for secondary prophylaxis. METHOD: Glucose tolerance testing (GTT) (oral 75 gm load) was performed on 35 patients who had recently reco
Radiographic manifestations of Pneumocystis carinii pneumonia (PCP) in patients receiving aerosolized pentamidine (AP) for secondary prophylaxis.: Int Conf AIDS. 1990 Jun 20-23;6(1):227 (abstract no. Th.B.423). Unique Identifier : AIDSLINE ICA6/10042390; Duguay D; Falutz J; Fanning M; Fong IW; Garber G; Gervais A; Gilmore N; Hyland R; Lawson L; Louie T; et al; Montreal General Hospital, Montreal, Canada; OBJECTIVE: We analyzed the CXR patterns of recurrent PCP in patients receiving long-term AP prophylaxis to determine whether upper lobe disease is the most common radiographic feature. METHODS: Chest x-ray reports of first PCP relapses in 44 patients after 5.5+/-3.2 months (range 0.6-11.7) prophylactic AP treatment, a
Ultrasound diagnosis of disseminated Pneumocystis carinii.: Int Conf AIDS. 1990 Jun 20-23;6(1):228 (abstract no. Th.B.424). Unique Identifier : AIDSLINE ICA6/10042490; Gopinath N; Blendis LM; Vellend H; Sherman M; Rachlis A; Wilson S; Cameron R; Read S; Phillips AM; University of Toronto, Toronto, Ontario, Canada; OBJECTIVE: Extrapulmonary pneumocystis carinii (PC) has been recognized with increasing frequency, possibly related to increasing use of aerosolized pentamidine prophylaxis (APP) in HIV disease. Ultrasound (U/S) was used to screen for PC. RESULTS: Two index cases led us to note a characteristic ultrasound appearance o
Unusual manifestations of Pneumocystis carinii infection in HIV positive subjects on prolonged inhaled pentamidine prophylaxis.: Int Conf AIDS. 1990 Jun 20-23;6(1):228 (abstract no. Th.B.425). Unique Identifier : AIDSLINE ICA6/10042590; Scheibel S; Valenti W; Williams C; Community Health Network, Rochester, New York, 14620, USA; OBJECTIVE: To review cases of pneumocystis carinii infection (PCI) among HIV positive subjects who have received prolonged inhaled pentamidine as primary or secondary prophylaxis. METHOD: Review of charts among 187 HIV positive subjects to determine cases of PCI among those patients receiving more than 6 months of inh
Atypical Pneumocystis carinii pneumonia (PCP) in patients receiving inhaled pentamidine prophylaxis (IPP).: Int Conf AIDS. 1990 Jun 20-23;6(1):228 (abstract no. Th.B.426). Unique Identifier : AIDSLINE ICA6/10042690; McCabe R; Edelstein H; University of California School of Medicine, Davis, CA; OBJECTIVE: Recent case reports have noted atypical presentations of PCP in pts receiving IPP. In order to assess the magnitude of this problem, we studied the frequency and characteristics of PCP in pts who received IPP. METHODS: Retrospective study of all pts with biopsy or cytology proven PCP at two hospitals from J
Clinical data of disseminated Pneumocystis carinii infection (D.P.C.I.) in 6 AIDS patients receiving secondary prophylaxis with aerosolized pentamidine (AP).: Int Conf AIDS. 1990 Jun 20-23;6(1):228 (abstract no. Th.B.427). Unique Identifier : AIDSLINE ICA6/10042790; Denis M; Guidet B; Lebas J; Tenon Hospital, Paris, France; OBJECTIVE OF THIS STUDY: To analyse clinical data in all AIDS patients (pts), seen during 1989 in the Eastern Paris Hospitals because of D.P.C.I. PATIENTS: 5 homosexual and 1 drug addict males, between 35 and 39 years old, treated with Zidovudine for 12 to 22 months because of AIDS. METHODS: In all cases, D.P.C.I. wer
Extrapulmonary Pneumocystis carinii in patients receiving aerosolized pentamidine.: Int Conf AIDS. 1990 Jun 20-23;6(1):229 (abstract no. Th.B.428). Unique Identifier : AIDSLINE ICA6/10042890; Noskin G; Murphy RL; Finn WG; Timins M; Northwestern University Medical School, Chicago, IL, USA; Pneumocystis carinii (PC) is the organism responsible for the most common cause of morbidity and mortality in patients infected with the HIV-1. Pneumocystis carinii pneumonia (PCP) occurs in 60-70% of patients with AIDS. Recently, aerosolized pentamidine has received widespread use for PCP prophylaxis. Because signifi
Disseminated Pneumocystis carinii infection in patients with AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):229 (abstract no. Th.B.429). Unique Identifier : AIDSLINE ICA6/10042990; Feuerstein I; Falloon J; Polis M; Pluda J; O'Neill D; Travis W; Masur H; National Institutes of Health, Bethesda, Maryland, USA; OBJECTIVE: To assess the clinical, laboratory, radiologic, and pathologic features of disseminated Pneumocystis carinii infection (DPCI) in patients with AIDS. METHODS: Retrospective review of charts, radiologic studies, and pathologic specimens of pts with AIDS and DPCI diagnosed either histologically or radiological
Is CMV viremia predictive of subsequent CMV retinitis?: Int Conf AIDS. 1990 Jun 20-23;6(1):229 (abstract no. Th.B.430). Unique Identifier : AIDSLINE ICA6/10043090; Stewart K; Hayes K; Mijch AM; McLean H; Hoy JF; Sandland AM; Lucas CR; Fairfield Hospital, Melbourne, Australia; OBJECTIVE: To evaluate the link between CMV shedding in saliva/urine and CMV viremia and the development of CMV retinitis. METHOD: One hundred and thirty-nine patients enrolled in 4 categories of HIV infection (established AIDS greater than 4 months, 42, new AID
Relationship between CMV culture positivity and circulating CD4 count in patients with HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):229 (abstract no. Th.B.431). Unique Identifier : AIDSLINE ICA6/10043190; Zurlo J; O'Neill D; Polis M; Manischewitz J; Davey R; Falloon J; Kovacs J; Zunich K; Yarchoan R; Lane H; et al; Clinical Center/NIAID/NCI, National Institutes of Health, and; FDA, Bethesda, Maryland, USA; OBJECTIVE: To determine the relationship between CMV urine and blood culture results and circulating CD4 counts in HIV infected patients. METHODS: The initial blood and urine CMV culture was assessed in all HIV infected patients who had a circulating CD4 count d
Ganciclovir (GCV) in AIDS patients with immediately sight-threatening CMV retinitis (ISTCR): initial summary of treatment IND data.: Int Conf AIDS. 1990 Jun 20-23;6(1):230 (abstract no. Th.B.432). Unique Identifier : AIDSLINE ICA6/10043290; Feinberg J; Katz D; Mastre B; DeArmond B; Division of AIDS, National Institute of Allergy and Infectious; Diseases, Bethesda, Maryland, USA; OBJECTIVE: To evaluate the safety and efficacy of intravenous GCV therapy in AIDS patients (pts) with ISTCR. GCV was distributed under the treatment IND mechanism which permits access by any licensed US physicians to a promising investigational drug with evidence of safety. METHODS: AIDS pts with ophthalmologist-confi
Three times a week maintenance ganciclovir to prevent relapse of CMV retinitis in AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):230 (abstract no. Th.B.433). Unique Identifier : AIDSLINE ICA6/10043390; Jennens I; Stewart K; McLean H; Slavin M; Sandland AM; Mijch AM; Hoy JF; Lucas CR; Fairfield Hospital, Melbourne, Australia; AIM: To determine the efficacy of ganciclovir infusions given three times per week as maintenance therapy to prevent relapse of CMV retinitis. METHODS: Forty-eight AIDS patients were treated at Fairfield Hospital with ganciclovir for CMV retinitis from June 1986
Intermittent and ambulatory treatment of CMV retinitis with foscarnet in AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):230 (abstract no. Th.B.434). Unique Identifier : AIDSLINE ICA6/10043490; Dohin E; Katlama C; Cochereau I; Ingrand D; Le Hoang P; Gentilini M; Hopital Pitie-Salpetriere - Paris - France; OBJECTIVE: Evaluation of efficacy and tolerance of intermittent administration of Foscarnet (PFA) in treatment of acute CMV retinitis. METHODS: Patients with acute retinitis were given PFA (200 mg/kg/d) through IV infusion. 2 regimens were used: A) 60 mg/kg/day
Maintenance therapy with foscarnet in prevention of cytomegalovirus (CMV) retinitis in AIDS patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):230 (abstract no. Th.B.435). Unique Identifier : AIDSLINE ICA6/10043590; Katlama C; Dohin E; Robinet M; Caumes E; Le Hoang P; Gentilini M; Hopital Pitie-Salpetriere, Paris, France; OBJECTIVE: Evaluate the efficacy and tolerance of Foscarnet (PFA) in maintenance therapy of CMV retinitis. PATIENTS: 22 patients who had successfully completed a PFA (100 mg/kg q 12 hours) with cicatrization of retinal lesions were given PFA in maintenance thera
An open study of foscarnet treatment of cytomegalovirus (CMV) retinitis in AIDS patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):231 (abstract no. Th.B.436). Unique Identifier : AIDSLINE ICA6/10043690; Leonard L; Lippe M; Follansbee S; Drennan D; Karol C; Davies Medical Center, San Francisco, CA, USA; OBJECTIVE: To evaluate the safety and efficacy of foscarnet treatment of CMV retinitis in AIDS patients. METHODS: Patients with AIDS and active CMV retinitis were enrolled. Some, but not all patients had prior DHPG treatment. Those completing a 14-21 day inducti
Treatment of ganciclovir (GCV) resistant cytomegalovirus (CMV) retinitis with foscarnet (PFA).: Int Conf AIDS. 1990 Jun 20-23;6(1):231 (abstract no. Th.B.437). Unique Identifier : AIDSLINE ICA6/10043790; Parenti DM; Drew WL; Feinberg JE; O'Donnell JJ; Whitmore PV; Miner R; Jacobson MA; The George Washington Univ. Med. Ctr., Wash., DC, USA; OBJECTIVE: To assess the activity of PFA on CMV retinitis in HIV-infected patients (PTS) with clinical and virologic resistance to GCV. METHODS: Retinitis progression was defined as either a new opacified lesion in a previously uninvolved area of either eye, or
Anti-CMV activity of foscarnet in a randomized controlled clinical trial for the treatment of non-sight threatening CMV retinitis.: Int Conf AIDS. 1990 Jun 20-23;6(1):231 (abstract no. Th.B.438). Unique Identifier : AIDSLINE ICA6/10043890; Manischewitz J; Golding H; Baird B; deSmet M; Polis M; FDA, Bethesda, MD, USA; OBJECTIVE: To evaluate the anti- CMV activity of foscarnet (fos) in patients on a clinical trial for the treatment of non-sight threatening CMV retinitis. METHODS: A randomized controlled clinical trial was conducted in AIDS patients (pts) with non-sight threaten
Effects of foscarnet on calcium homeostasis in man.: Int Conf AIDS. 1990 Jun 20-23;6(1):231 (abstract no. Th.B.439). Unique Identifier : AIDSLINE ICA6/10043990; Nauss-Karol C; Redding K; Sagaties M; Gray W; Ussery F 3d; Astra Pharmaceutical Products, Inc., Westborough, MA, USA; OBJECTIVE: To determine the effects of foscarnet on serum ionized calcium (CA++), parathyroid hormone (PTH) and 1,25-dihydroxycholecalciferol (1,25(OH)2D3) levels in man. In dogs, foscarnet treatment by continuous intravenous (IV) infusion is known to reduce Ca++ and elevate PTH and 1,25(OH)2D3. METHODS: AIDS patients
Genital ulcerations (GU) occurring during foscarnet (F) therapy.: Int Conf AIDS. 1990 Jun 20-23;6(1):232 (abstract no. Th.B.440). Unique Identifier : AIDSLINE ICA6/10044090; Picard C; Salmon D; Fegueux S; Longuet P; Sauvage C; Gilquin J; Desmoulins T; Hopital Bichat-Claude Bernard, Paris, France; OBJECTIVE: To describe a new side effect of F observed in AIDS patients (pts). METHODS: Between 1985 and 1989, AIDS pts who developed G.U under F therapy for CMV retinitis, were evaluated with biological, viral, bacteriological and histological investigations. R
Suppression of CMV retinitis with high dose intravenous (IV) acyclovir (ACV).: Int Conf AIDS. 1990 Jun 20-23;6(1):232 (abstract no. Th.B.441). Unique Identifier : AIDSLINE ICA6/10044190; Sha B; Benson C; Deutsch T; Pottage J; Urbanski P; Kessler H; Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois,; USA; OBJECTIVE: To evaluate the efficacy and safety of high dose IV ACV in combination with zidovudine (ZDV) as suppressive therapy for CMV retinitis in AIDS patients. METHODS: A single arm, open-label, phase 2 pilot study using ACV 10 mg/kg IV q 8 hours plus ZDV 200
Human monoclonal antibody to cytomegalovirus (TI-23); pharmacokinetics and toxicity study in HIV seropositive patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):232 (abstract no. Th.B.442). Unique Identifier : AIDSLINE ICA6/10044290; Petersen E; Kaplan C; Fish D; Hersh E; Grayson J; Gray J; Masuho Y; University of Arizona, Tucson, Arizona, USA; OBJECTIVE: To determine the toxicity and pharmacokinetics of TI-23, a human anti- cytomegalovirus ( CMV ) monoclonal antibody in HIV seropositive persons. METHODS: TI-23 is produced from a fusion of human splenic lymphocytes wit
Gastrointestinal CMV-manifestations in AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):232 (abstract no. Th.B.443). Unique Identifier : AIDSLINE ICA6/10044390; Heise W; Mostertz P; Arasteh K; Skorde G; Grosse G; L'age M; Auguste-Viktoria-Hospital, Berlin, West Germany, II. Intern.Dpt.; OBJECTIVE: To describe clinical, diagnostic and endoscopic findings in gastrointestinal (GI) cytomegalovirus ( CMV ) lesions and their therapeutical response to therapy with ganciclovir. METHODS: Upper and lower GI tract endosc
CMV encephalitis in AIDS patients: frequency and significance of diagnostic procedures, results from a clinico-pathological study.: Int Conf AIDS. 1990 Jun 20-23;6(1):233 (abstract no. Th.B.444). Unique Identifier : AIDSLINE ICA6/10044490; Habicht S; Jautzke G; Iglesias JR; Schurmann D; Pohle HD; Ruf B; II. Department of Internal Medicine, Rudolf Virchow University; Hospital (Wedding), Freie Universitat Berlin, FRG; OBJECTIVE: To evaluate the frequency and clinical manifestations of CMV encephalitis and the significance of diagnostic procedures. METHODS: Analysis of data from AIDS patients (n=65) with a complete clinical follow-up and autopsy investigation. CMV diagnosis: s
Bronchoscopy cultures for the diagnosis of cytomegalovirus (CMV) pneumonia.: Int Conf AIDS. 1990 Jun 20-23;6(1):233 (abstract no. Th.B.445). Unique Identifier : AIDSLINE ICA6/10044590; Nichols L; Klatt EC; Appleman MD; DeGirolami PC; Balogh K; Los Angeles County-University of Southern California Medical; Center (LAC-USC MC), Los Angeles, CA, USA; OBJECTIVE: To assess the potential usefulness of bronchoscopy cultures for the diagnosis of CMV pneumonia in patients with AIDS. METHODS: We correlated detection of CMV in bronchoscopy specimens by culture with definitive diagnosis of CMV pneumonia at autopsy ine
Evolution of foscarnet and acyclovir resistant herpes simplex infection in response to therapy.: Int Conf AIDS. 1990 Jun 20-23;6(1):233 (abstract no. Th.B.446). Unique Identifier : AIDSLINE ICA6/10044690; Doherty R; Hayes K; Birch C; Macfarlane Burnet Centre for Medical Research, Fairfield; Hospital, Victoria, Australia; OBJECTIVE: Foscarnet resistance developed in severe genital Herpes Simplex Virus 2 (HSV2) infection in a young woman with AIDS. Partly successful symptomatic management of lesions was achieved with topical interferon (IFN) and trifluorothymidine (TFT). METHODS & RESULTS: Our patient presented with HSV2 unresponsive
Foscarnet (PFA) induction and maintenance therapy for acyclovir-resistant (ACV-R) herpes simplex (HSV) infections in AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):233 (abstract no. Th.B.447). Unique Identifier : AIDSLINE ICA6/10044790; Tan C; Hardy D; Chafey S; Karol C; UCLA School of Medicine, Los Angeles, CA, USA; OBJECTIVE: To determine the safety, clinical and virologic efficacy and maintenance therapy (Rx) requirements of PFA for ACV-R HSV infections in AIDS patients (pts). METHODS: Six AIDS pts with persistent HSV infections (5-perianal, 1-facial) clinically and virologically well-documented to be resistant to ACV (ID50 gre
Herpes zoster and HIV infection in Rwanda.: Int Conf AIDS. 1990 Jun 20-23;6(1):234 (abstract no. Th.B.448). Unique Identifier : AIDSLINE ICA6/10044890; Harelimana F; Bugingo G; National University of Rwanda, Butare, Rwanda; OBJECTIVE: To describe the clinical and epidemiological features of HIV related Herpes Zoster (HZ) in Rwanda , a country in Central Africa where the HIV infection and AIDS are common. METHODS: Between January 1985 and November 1989, 793 patients chosen from the Dermatology Clinic s
Clinical and epidemiological considerations on 31 cases of progressive multifocal leukoencephalopathy (PML) in AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):234 (abstract no. Th.B.449). Unique Identifier : AIDSLINE ICA6/10044990; Galli M; Vago L; Rizzardini G; Coen M; Isabella L; Albarello V; Castagna A; Costanzi G; Clinic of Infectious Diseases, University of Milan, Milan, Italy; OBJECTIVE: 1) To assess the prevalence of PML in a large autopsied series of AIDS cases. 2) To identify early clinical signs of PML. METHODS: A series of 385 consecutive AIDS autopsies performed at L. Sacco Hospital, Milan from 1984 to 1989 was reviewed. Histological diagnosis of PML was confirmed by anti SV40 MoAb an
Prevalence of polyomavirus infection in brain tissue from AIDS patients detected by DNA hybridizations.: Int Conf AIDS. 1990 Jun 20-23;6(1):234 (abstract no. Th.B.450). Unique Identifier : AIDSLINE ICA6/10045090; Ingrand D; Moret H; Sazdovitch V; Agut H; Huraux JM; Laboratoire de Virologie du CERVI, Hopital de la Pitie, France; OBJECTIVE: We have conducted a prospective study to determine the prevalence of polyomavirus (BK virus and JC viruses) in brain tissue from AIDS patients suspected of having CNS virus involvement. METHODS: Brain material were frozen immediately after autopsy and stored at -70 degrees C. DNA from frozen tissue was trea
Naturally acquired antibody to hepatitis B surface antigen in HIV infected patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):234 (abstract no. Th.B.451). Unique Identifier : AIDSLINE ICA6/10045190; Vandercam B; Omar M; Cahill M; Mardon J; Cornu C; Shawky S; Zech F; Lamy M; Departments of Internal Medicine and Virology. Cliniques; Universitaires Saint-Luc, 1200 Brussels - Belgium; INTRODUCTION: HIV infection may interfere with the natural course of hepatitis B virus (HBV) infection and failure to show an adequate antibody response to hepatitis B vaccine has been described. In this study, we examine the level and the evolution of antibody to hepatitis B surface antigen (anti-HBs) according to th
Seroprevalence of hepatitis C virus antibodies in HIV European seropositive patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):235 (abstract no. Th.B.452). Unique Identifier : AIDSLINE ICA6/10045290; Ranger S; Weinbreck P; Loustaud V; Mounier M; Delpeyroux C; Denis F; Department of Bacteriology-Virology, CHU Dupuytren, Limoges,; France; OBJECTIVE: Seroprevalence evaluation of HCV comparatively to seroprevalence of HBV and HDV in a population of HIV seropositive patients. MATERIAL AND METHODS: 150 HIV seropositive patients living in France , well documented (source of contamination, clinical assessment according to
The role of hepatitis C (HCV) and HIV infections in the chronic liver disease of hemophiliacs.: Int Conf AIDS. 1990 Jun 20-23;6(1):235 (abstract no. Th.B.453). Unique Identifier : AIDSLINE ICA6/10045390; Hatzakis A; Yannitsiotis A; Polychronaki H; Karafoulidou A; Gialeraki A; Katsouyanni K; Mandalaki T; Athens Univ. Medical School, Athens, Greece; OBJECTIVE: Hepatitis C virus is associated with non-A, non-B hepatitis (NANBH) which is a major cause of chronic liver disease. Chronic hepatitis (CH) is a frequent cause of morbidity in hemophiliacs who consist a unique population to determine the impact and interactions of HCV and HIV infections in CH. METHODS: 210
Relation between decreasing seric CD4 lymphocytes count and outcome of cryptococcosis in AIDS patients: a basis for new diagnosis strategy.: Int Conf AIDS. 1990 Jun 20-23;6(1):235 (abstract no. Th.B.454). Unique Identifier : AIDSLINE ICA6/10045490; Lecomte I; Meyohas MC; De Sa M; Tenon Hospital, Paris, France; Cryptococcosis (C.D.) due to Cryptococcus neoformans is the most frequent disseminated fungal infection in AIDS patients (pts). Its prognosis depends on the precocity of treatment. Screening for soluble cryptococcal antigen (SCA) in sera is the easiest way for early diagnosis and consequent early treatment. OBJECTIVE
Pulmonary cryptococcosis in AIDS patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):235 (abstract no. Th.B.455). Unique Identifier : AIDSLINE ICA6/10045590; Boucot I; Roux P; Poirot JL; Tenon Hospital, Paris, France; OBJECTIVE: To study the incidence, presentation and clinical course of pulmonary cryptococcosis (PC) in AIDS patients (pts). METHODS: Thirty nine pts with AIDS and cryptococcosis diagnosed between January 1982 and December 1989 were reviewed retrospectively. Twenty pts had documented PC but data of 18 were available f
Effect of pronase treatment on cryptococcal antigen tests on specimens from AIDS patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):236 (abstract no. Th.B.456). Unique Identifier : AIDSLINE ICA6/10045690; Noble A; Hamilton JR; Stevens DA; Denning DW; Santa Clara Valley Med. Center, San Jose, CA, USA; OBJECTIVE: We evaluated the effect of pronase on cryptococcal antigen (CA) detection, titers and unclear test reactions. METHOD: Ninety-seven sera and 42 CSF from 37 HIV+ patients (pts) were tested before and after pronase with the Meridian Diagnostics kit. RESULTS: Twenty-six (27%) sera (no CSF) were negative before
The significance of isolated positive cerebrospinal fluid cryptococcal antigen in HIV-infected patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):236 (abstract no. Th.B.457). Unique Identifier : AIDSLINE ICA6/10045790; Gurtman A; Masci J; Pierone G; Nicholas P; Mount Sinai Services, Elmhurst Hospital Center, Elmhurst, N.Y.,; USA; OBJECTIVE: To determine the incidence and significance of isolated positive (+) cryptococcal antigen assay (CA) from CSF in HIV+ patients (pts). METHODS: All CA performed between 12/87 and 4/89 were identified. Cases in which CA was + in the cerebrospinal fluid (CSF) but not in the serum and cultures were negative wer
AIDS-related cryptococcosis in Rwanda, epidemiological features.: Int Conf AIDS. 1990 Jun 20-23;6(1):236 (abstract no. Th.B.458). Unique Identifier : AIDSLINE ICA6/10045890; Bogaerts J; Taelman H; Abdel Aziz M; Kagame A; Batungwanayo J; Msellati P; Swinne D; De Yroey C; Departments of Microbiology, Internal Medicine, Centre; Hospitalier de Kigali (CHK), Rwanda; OBJECTIVE: To study the epidemiological features of AIDS-related cryptococcosis (C) in Kigali, Rwanda , between January 1983 and December 1989. METHODS: 1. Each patient with suspected meningitis (meningeal signs and/or unexplained fever, headache, altered mentation) had a CSF examin
Intravenous and oral fluconazole in the treatment of acute cryptococcal meningitis.: Int Conf AIDS. 1990 Jun 20-23;6(1):236 (abstract no. Th.B.459). Unique Identifier : AIDSLINE ICA6/10045990; Sanjana V; Cortes H; Davidson M; Mullen M; Boyle D; Raviglione M; Cabrini Medical Center, NYC, NY, USA; OBJECTIVE: To assess the efficacy and tolerance of fluconazole (fcz) in the treatment of acute cryptococcal meningitis. METHODS: Protocol I: 11 consecutive patients with acute cryptococcal meningitis received I.V. fcz 400mg loading dose, followed by 200mg/day for 2 weeks, then 200mg/day orally thereafter, with a doubl
Fluconazole (Flu): a first-line drug for cryptococcosis (C) in AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):237 (abstract no. Th.B.460). Unique Identifier : AIDSLINE ICA6/10046090; Marchou B; Pascal C; Carles M; Reynes J; Hop Purpan, Toulouse, France; From 06.85 to 09.89, 29 AIDS pts have been treated for C. There were 28 M/1 F, mean age: 37 years (+/-10,6), HIV infected via sexual (22) contact, I.V.D.U. (9) or blood transfusion (2). C. was the 1st manifestation of AIDS in 18 pts (62%). Disseminated C. defined as a positive latex test in blood (24) or CSF (21), or
Lack of survival benefit and frequent neurologic complications of intrathecal amphotericin B for cryptococcal meningitis.: Int Conf AIDS. 1990 Jun 20-23;6(1):237 (abstract no. Th.B.461). Unique Identifier : AIDSLINE ICA6/10046190; Holtom PD; Leal M; Riley K; Larsen R; University of Southern California, Los Angeles, California, USA; OBJECTIVE: To determine whether addition of intrathecal (IT) amphotericin B would improve outcome in patients with AIDS and cryptococcal meningitis when compared with standard therapy. METHODS: The population was AIDS patients at LAC/USC Medical Center with culture proven cryptococcal meningitis. Patients were randoml
The incidence of colonization and invasive disease in a population of AIDS patients with Aspergillus species.: Int Conf AIDS. 1990 Jun 20-23;6(1):237 (abstract no. Th.B.462). Unique Identifier : AIDSLINE ICA6/10046290; Pursell KJ; Paredes J; Gold J; Carrow M; Armstrong D; Memorial Sloan-Kettering Cancer Center (MSKCC), New York, N.Y.,; USA; OBJECTIVE: To determine the incidence of colonization and invasive aspergillosis (IA) in a population of AIDS patients with Aspergillus species. METHODS: Retrospective review of the medical records (including autopsy data when available) for all patients with Aspergillus isolated from sputum antemortem. RESULTS: Among
Aspergillus infection in AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):237 (abstract no. Th.B.463). Unique Identifier : AIDSLINE ICA6/10046390; Just-Nuebling G; Helm EB; Laubenberger C; Falk S; Keul HG; Hubner K; Grafin Vitzthum H; Wolki U; Schlote W; Stille W; Zentrum der Inneren Medizin, Johann Wolfgang Goethe University,; Theodor-Stern-Kai 7, 6000 Frankfurt, FRG; OBJECTIVE: Aspergillus infections are a complication known to occur in the immunocompromised host. With this study we report on incidence as well as the clinical and pathological findings of invasive Aspergillosis in AIDS-patients. METHODS: Between 5/82 and 12/89 510 patients with full blown AIDS were treated at our h
Pulmonary aspergillosis (ASP) in AIDS: patterns of disease (dis.), predisposing factors and outcome in 12 patients (P).: Int Conf AIDS. 1990 Jun 20-23;6(1):238 (abstract no. Th.B.464). Unique Identifier : AIDSLINE ICA6/10046490; Denning DW; Follansbee S; Scolaro M; Norris S; Edelstein H; Stevens DA; Sta. Clara Vly. Med. Ctr. (Stanford U.), Inst. Med. Res., San; Jose, CA, USA; OBJECTIVE: To describe the features of pulmonary ASP in AIDS, as infrequently reported in AIDS P although common in other immunocompromised P. METHODS: Diagnosis (D) of ASP was confirmed by: autopsy 2, aspiration of lung or rib 4, bronchoalveolar lavage culture (cx) positive with no other pathogen and new clinical and
Prospective comparative study of gentian violet, ketoconazole and nystatin to treat oral and oesophageal candidiasis in AIDS patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):238 (abstract no. Th.B.465). Unique Identifier : AIDSLINE ICA6/10046590; Nyst M; Perriens J; Lusakumunu K; Kapita B; Piot P; Projet SIDA, Kinshasa, Zaire; METHODS: AIDS patients (pts) hospitalized in the internal medicine wards of Mama Yemo Hospital with oral and oesophageal candidiasis were randomized to receive gentian violet 0.5%, b.i.d. (G), or nystatin (N) 500.000 U q.i.d. mouth washes, or oral ketoconazole (K) 200 mg/d, until complete resolution of oral lesions an
Fluconazole preventive therapy for candida esophagitis in AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):238 (abstract no. Th.B.466). Unique Identifier : AIDSLINE ICA6/10046690; Lavilla P; Gil A; Valencia ME; Pintado V; Dupla JM; Puig JG; Hospital La Paz, Universidad Autonoma, Madrid, Spain; OBJECTIVE: To assess the efficacy of a weekly fluconazole (FZ) regime to prevent the relapse of esophageal candidiasis (EC) in AIDS patients. METHODS: From March 1988 to December 1989, 21 AIDS patients (14 male, 7 female) with a previous episode of EC were evaluated. Resolution of EC was confirmed by endoscopy, biopsy
Treatment of esophageal candidiasis (EC) with fluconazole: a prospective study.: Int Conf AIDS. 1990 Jun 20-23;6(1):238 (abstract no. Th.B.467). Unique Identifier : AIDSLINE ICA6/10046790; De Wit S; Rahir F; Urbain D; Clumeck N; Division of Infectious Diseases, St Pierre University Hospital,; Brussels, Belgium; OBJECTIVE: To assess the efficacy and tolerance of Fluconazole for the treatment of EC associated with AIDS. METHODS: During an 18 month period all HIV patients (P) with an esophagoscopy documented EC have been treated with Fluconazole 100mg daily. Therapeutical response was ascertained by disappearance of clinical si
Fluconazole resistance during suppressive therapy of AIDS-related thrush and esophagitis caused by Candida albicans.: Int Conf AIDS. 1990 Jun 20-23;6(1):239 (abstract no. Th.B.468). Unique Identifier : AIDSLINE ICA6/10046890; Fulton P; Phillips P; University of British Columbia, Vancouver, BC, Canada; OBJECTIVE: To document the development of clinical relapse associated with in vitro resistance of C. albicans to fluconazole. PATIENTS, METHODS, AND RESULTS: A 28 year old female was diagnosed with AIDS, thrush and Candida esophagitis in 1988. Initial treatment and suppressive
Coccidioidomycosis during HIV infection. A continuing prospective study.: Int Conf AIDS. 1990 Jun 20-23;6(1):239 (abstract no. Th.B.469). Unique Identifier : AIDSLINE ICA6/10046990; Ampel NM; Dols CL; Galgiani JN; Tucson Veterans Affairs Medical Center, AZ, USA; OBJECTIVE: To determine the epidemiology, clinical manifestations and outcome of coccidioidomycosis (coccy) among subjects infected with HIV in an area endemic for Coccidioides immitis. METHODS: HIV-positive subjects living in Tucson and Phoenix, Arizona, have been p
Epidemiology and immunologic characteristics of symptomatic coccidioidomycosis in patient with HIV/AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):239 (abstract no. Th.B.470). Unique Identifier : AIDSLINE ICA6/10047090; Cone L; Woodard D; Fiala M; Christopher S; Sneider R; Eisenhower Medical Center, Rancho Mirage, California, 92270, USA; OBJECTIVE: To define the frequency, clinical course and immunologic alterations associated with coccidioidomycosis in patients with HIV/AIDS residing in an area endemic for the pathogen, the Coachella Valley of Southern California. METHODS: A chart review of all AIDS
A higher than expected frequency of histoplasmosis: importance of routine obtainment of blood cultures for fungi.: Int Conf AIDS. 1990 Jun 20-23;6(1):239 (abstract no. Th.B.471). Unique Identifier : AIDSLINE ICA6/10047190; Peixoto MA; Caiuby MJ; Assis TL; Schechter M; AIDS Program Federal University of Rio de Janeiro, Brazil; OBJECTIVE: To demonstrate the importance of routinely obtaining blood cultures for fungi in AIDS patients, independent of presenting signs and symptoms. METHODS: Blood cultures were routinely obtained from all HIV positive patients admitted to the University Hospital of the Federal University of Rio de Janeiro and see
Amphotericin B in the treatment and prevention of AIDS: selective reduction of cytotoxicity by complexing to lipids.: Int Conf AIDS. 1990 Jun 20-23;6(1):240 (abstract no. Th.B.472). Unique Identifier : AIDSLINE ICA6/10047290; Pontani DR; Wolf B; Zuberbuehler D; Bryant P; Plescia OJ; Schaffner C; Shahied SI; N.J. State Dept. of Health, Trenton, N.J., USA; OBJECTIVE: To show the efficacy of lipid complexing with amphotericin B to reduce cytotoxicity. METHODS: Amphotericin B at concentrations of 5, 33, and 50 mole% was complexed to lipid, using Dimyristoyl Lecithin and Dimyristoyl Phosphatidylglycerol in chloroform according to the method of Janoff et al. Once complexed
Toxoplasmosis in Spanish AIDS patients. A multicenter retrospective study.: Int Conf AIDS. 1990 Jun 20-23;6(1):240 (abstract no. Th.B.473). Unique Identifier : AIDSLINE ICA6/10047390; Bolao F; Podzamczer D; Miro JM; Sirera G; Cosin J; Gudiol F; Hospital Bellvitge, Barcelona, Spain; OBJECTIVE: To evaluate the clinical, radiological and therapeutic characteristics of a large series of Spanish AIDS pts with cerebral toxoplasmosis (CTx). METHODS: AIDS was diagnosed according to 1987 CDC definition, and CTx was diagnosed using clinical (96%) or histological (4%) criteria. CTx cases were retrospective
Isolation of Toxoplasma gondii in lymph nodes of patients with HIV infection and generalized lymphadenopathy.: Int Conf AIDS. 1990 Jun 20-23;6(1):240 (abstract no. Th.B.474). Unique Identifier : AIDSLINE ICA6/10047490; De la Rubia L; Fernandez Martin J; Vazquez JJ; Gamallo C; Barbado FJ; de Diego JA; La Paz Hospital & Parasitology Dpt. U.A.M. Madrid. Spain; OBJECTIVES: To establish a relationship between generalized lymphadenopathy (GL) in HIV patient and Toxoplasma Gondii (TG) infection. To analyze the effectiveness of a new diagnostic method. METHODS: We include 30 patients (24 IVDUs, 5 Homosexuals, 1 IVDU-homosexual). 24 males and 6 females. Mean age 26 years. CDC cla
Cerebral toxoplasmosis in AIDS patients: accuracy of presumptive diagnostic criteria.: Int Conf AIDS. 1990 Jun 20-23;6(1):240 (abstract no. Th.B.475). Unique Identifier : AIDSLINE ICA6/10047590; Antonucci G; Antonelli L; Armignacco O; Galgani S; Grillo LR; Tozzi V; L. Spallanzani Hosp. for Infectious Diseases, Rome, Italy; OBJECTIVE AND METHODS: To evaluate the diagnostic accuracy of cerebral toxoplasmosis in AIDS patients (pts) using clinical features, imaging findings and conventional treatment response. RESULTS: Cerebral toxoplasmosis was suspected and treated in 52 HIV-infected subjects observed from 1987 to 1989. In 37 pts the diag
Prevalence of toxoplasmosis in 365 AIDS and ARC patients before and during zidovudine treatment.: Int Conf AIDS. 1990 Jun 20-23;6(1):241 (abstract no. Th.B.476). Unique Identifier : AIDSLINE ICA6/10047690; Matheron S; Dournon E; Garakhanian S; Leport C; Detruchis P; Gaudebout C; ZDV Claude Bernard Study Group, Paris. France.; OBJECTIVE: To study, in 285 AIDS and 80 ARC patients (pts), the prevalence of toxoplasmosis (Toxo) before and during Zidovudine therapy (ZDV Rx). METHODS: 365 pts were treated with ZDV, 200 mg/4h whenever possible (n=260) or 200mg/8h otherwise (n=105) and prospectively followed (Lancet; 1988;ii,1297) for a mean (range
Cotrimoxazole treatment of toxoplasma encephalitis in AIDS patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):241 (abstract no. Th.B.477). Unique Identifier : AIDSLINE ICA6/10047790; Canessa A; Del Bono V; De Leo P; Pagano G; Piersantelli N; Terragna A; Department of Infectious Diseases, University of Genoa, Genoa,; Italy; OBJECTIVE: To evaluate the efficacy of cotrimoxazole (trimethoprim-sulfamethoxazole) in the treatment of Toxoplasma encephalitis in AIDS patients. METHODS: Twenty-five AIDS patients with cerebral lesions consistent with cerebral toxoplasmosis and treated with 40-50 mg/kg cotrimoxazole daily were retrospectively examin
Treatment of brain toxoplasmosis by Fansidar.: Int Conf AIDS. 1990 Jun 20-23;6(1):241 (abstract no. Th.B.478). Unique Identifier : AIDSLINE ICA6/10047890; Paulic P; Pestre P; Bonnet E; Gasquet J; Prodhome C; Gallais H; Infectious disease unit Marseille France; OBJECTIVE: To give an estimation of the efficiency and tolerance of Fansidar (R) in the treatment of brain toxoplasmosis. METHODS: 36 HIV seropositive patients suffering from brain toxoplasmosis diagnosed by scanner (confirmed or not by serology) have been treated by Fansidar (R) during the acute phase, at the rate of
Failure of doxycycline in the treatment of cerebral toxoplasmosis.: Int Conf AIDS. 1990 Jun 20-23;6(1):241 (abstract no. Th.B.479). Unique Identifier : AIDSLINE ICA6/10047990; Turett G; Pierone G; Masci J; Nicholas P; Mount Sinai Services, Elmhurst Hospital Center, Elmhurst, N.Y.,; USA; OBJECTIVE: To determine the effectiveness of doxycycline for the treatment of cerebral toxoplasmosis in AIDS patients intolerant to sulfadiazine and pyrimethamine (S/P). METHODS: Prior to 1987, on the basis of experimental animal data, doxycycline (100 mg po BID) was used as second line therapy for patients with cereb
Sulphadiazine desensitisation in patients with AIDS and cerebral toxoplasmosis.: Int Conf AIDS. 1990 Jun 20-23;6(1):242 (abstract no. Th.B.480). Unique Identifier : AIDSLINE ICA6/10048090; Tenant-Flowers M; Boyle M; Carey D; Marriott D; Cooper DA; Penny R; Department of Immunology, St. Vincent's Hospital, Sydney, N.S.W.; Australia; OBJECTIVES: To evaluate the efficacy of a sulpahdiazine desensitisation protocol for use in the treatment of patients with AIDS and cerebral toxoplasmosis who are allergic to sulpha drugs. METHODS: Sixteen AIDS patients with cerebral toxoplasmosis and a past history or current manifestations of sulpha allergy were des
Relation between decreasing seric CD4 lymphocyte count and outcome of toxoplasmosis in AIDS patients: a basis for primary prophylaxis.: Int Conf AIDS. 1990 Jun 20-23;6(1):242 (abstract no. Th.B.481). Unique Identifier : AIDSLINE ICA6/10048190; Eliaszewicz M; Lecomte I; De Sa M; Saint-Antoine Hospital, Paris, France; Cerebral Toxoplasmosis which occurs in 20-50% of AIDS patients (pts) worldwide and particularly in some 40% in France , is one of the most frequent opportunistic infections (OI) in HIV-infected pts. Consequently, it is necessary to identify high risk pts for toxoplasmosis in order t
Trimethoprim-sulfamethoxazole in the prevention of cerebral toxoplasmosis.: Int Conf AIDS. 1990 Jun 20-23;6(1):242 (abstract no. Th.B.482). Unique Identifier : AIDSLINE ICA6/10048290; Nicholas P; Pierone G; Lin J; Gertman A; Schechter C; Masci J; Mt Sinai Services, Elmhurst Hospital Center, Elmhurst, N.Y., USA; OBJECTIVE: To determine if trimethoprim-sulfamethoxazole (T/S) prescribed for prophylaxis of Pneumocystis carinii pneumonia (PCP) also prevents cerebral toxoplasmosis (toxo). METHODS: Charts were reviewed on all patients receiving T/S and inhaled pentamidine (IP) for the prophylaxis of PCP. T/S was routinely prescribe
Intermittent maintenance therapy for toxoplasmic encephalitis (TE) in AIDS patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):242 (abstract no. Th.B.483). Unique Identifier : AIDSLINE ICA6/10048390; Gonzalez-Clemente JM; Miro JM; Pedrol E; Gatell JM; Guelar A; Valls ME; Infectious Diseases and Microbiology Units, Hospital Clinic,; Barcelona, Spain; OBJECTIVE: To describe the efficacy of an intermittent (2 days per week) maintenance therapy to avoid relapses on TE in AIDS patients. METHODS: Seventy four episodes of TE were accepted in 53 of the 374 AIDS cases when the clinical and computed tomographic (CT) scan findings were consistent unless an alternative diagn
Prevention of toxoplasma activation among immunocompromised patients; a decision analysis.: Int Conf AIDS. 1990 Jun 20-23;6(1):243 (abstract no. Th.B.484). Unique Identifier : AIDSLINE ICA6/10048490; Rose DN; Mount Sinai School of Medicine, New York, NY, USA; OBJECTIVE: To determine the thresholds of safety and effectiveness which would justify immunocompromised patients taking preventive therapy (PrevRx) to prevent activation of latent Toxoplasma gondii infection (TOXO). METHODS: A decision analysis using a Markov model was used to simulate events for hypothetical cohorts
A retrospective cohort study of the incidence of tuberculosis (TB) among child-bearing women with HIV infection in Kinshasa, Zaire.: Int Conf AIDS. 1990 Jun 20-23;6(1):243 (abstract no. Th.B.485). Unique Identifier : AIDSLINE ICA6/10048590; Badi N; Braun M; Ryder R; Nsa W; Willame J; Kaboto M; Heyward W; Projet SIDA, Kinshasa, Zaire; OBJECTIVE: To determine the incidence of TB in persons with HIV infection. METHODS: A cohort of 249 HIV(+) and 310 HIV(-) postnatal women were retrospectively studied over a 3-year period for incidence of TB. RESULTS: After a median follow-up of 32 months, there were 22 new self-reported cases of TB among HIV(+) subje
Cohort study of HIV infected tuberculosis patients, Nairobi, Kenya; data at presentation and mortality.: Int Conf AIDS. 1990 Jun 20-23;6(1):243 (abstract no. Th.B.486). Unique Identifier : AIDSLINE ICA6/10048690; Nunn P; Wasunna K; Kwanyah G; Gathua S; Brindle R; Omwega M; Were J; McAdam K; Elliott A; HIV/TB Project, Kenya Medical Research Institute, Nairobi, Kenya; OBJECTIVES: To assess HIV seroprevalence among a cohort of newly presenting TB patients, and compare clinical characteristics of HIV+ and HIV- TB. METHODS: 240 consecutive patients with newly diagnosed TB presenting to Infectious Diseases Hospital were enrolled as part of a longitudinal study. RESULTS: 73/240 (30%) we
A prospective study of pulmonary tuberculosis and HIV infection in intravenous drug abusers (IDA's) in detoxification.: Int Conf AIDS. 1990 Jun 20-23;6(1):243 (abstract no. Th.B.487). Unique Identifier : AIDSLINE ICA6/10048790; Muga R; Tor J; Contijoch C; Villanueva C; Manterola JM; Foz M; Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain; OBJECTIVE: To determine the incidence of Pulmonary tuberculosis (PT) and HIV infection in a longitudinal study focused to asymptomatic IDA s admitted to a detoxification unit. METHODS: From Feb 1987 to Oct 1989, 194 IDA s (39 F, 155 M) were consecutively registered. Rx of chest, Ziehl stains in 3 samples of sputum and
Tuberculosis among HIV infected individuals. Different patterns in Buenos Aires, Argentina and Vancouver, Canada.: Int Conf AIDS. 1990 Jun 20-23;6(1):244 (abstract no. Th.B.488). Unique Identifier : AIDSLINE ICA6/10048890; Gonzalez Montaner PJ; Montaner JS; Blackie S; Musella RM; Vedal S; Benetucci J; Lawson LM; Abatte E; Romano H; Quieffin J; et al; University of Buenos Aires, Argentina; OBJECTIVE: To describe the varying patterns of tuberculosis in Buenos Aires (BsAs) and Vancouver (Vanc), two large metropolitan cities with different socioeconomic and epidemiological characteristics. METHODS: Cases were collected from Oct 1, 1985 to Dec 31, 1988 at the University s ID Tb and Chest Hospital in BsAs wh
A study of HIV infection in association with tuberculosis as seen in infectious diseases hospital (IDH) Nairobi.: Int Conf AIDS. 1990 Jun 20-23;6(1):244 (abstract no. Th.B.489). Unique Identifier : AIDSLINE ICA6/10048990; Kibuga DK; Gathua S; Infectious Diseases Hospital, (IDH) Nairobi, Kenya; OBJECTIVE: Assess prevalence of HIV infection, associated complications and response to chemotherapy of all patients attended between January 1987 - June 1988 with tuberculosis. METHOD: 656 patients were HIV tested by organon or Wellcozyme technique and Western blot confirmation done when possible. They have been foll
HIV-1 infection in adult tuberculosis patients in Cite Soleil, Haiti.: Int Conf AIDS. 1990 Jun 20-23;6(1):244 (abstract no. Th.B.490). Unique Identifier : AIDSLINE ICA6/10049090; Clermont HC; Chaisson RE; Davis H; Boulos R; Holt E; Halsey NA; Ruff AJ; Coberly J; Boulos C; Centers for Development and Health, Cite Soleil, Haiti; OBJECTIVE: To assess the prevalence and clinical features of HIV-1 infection in adult tuberculosis (TB) patients in an impoverished urban area of Haiti . METHODS: From 1 January through 31 December 1989, newly diagnosed TB patients greater than or equal to 15 years old at the Cite So
Tuberculosis and AIDS in a Mexican hospital.: Int Conf AIDS. 1990 Jun 20-23;6(1):244 (abstract no. Th.B.491). Unique Identifier : AIDSLINE ICA6/10049190; Romo J; Salido F; Jessurum J; Higuera F; Hospital General de Mexico SS. Servicio de Infectologia. Mexico; City. Mexico; OBJECTIVE: Estimation of tuberculosis importance in AIDS patients. METHODS: 200 AIDS patients registered during a three-year period at the infectology unit, were evaluated through clinical assessment and the following: smears, cultures, biopsies, immunodiagnosis, therapeutic response and necropsies. Time related incre
AIDS and tuberculosis. Encounter between two epidemics in a Latin American country.: Int Conf AIDS. 1990 Jun 20-23;6(1):245 (abstract no. Th.B.492). Unique Identifier : AIDSLINE ICA6/10049290; Garcia ML; Valdespino JL; Salcedo A; Mora JL; Bravo E; Sepulveda JA; General Directorate of Epidemiology, Ministry of Health, Mexico; OBJECTIVE: To analyze the clinical and epidemiological features of tuberculosis (Tb) in AIDS cases in Mexico . METHODS: National AIDS registry data were analyzed. RESULTS: Tuberculosis was diagnosed in 234/3512 (7%) of notified AIDS patients, representing 10.3% of all infections, an
Comparison of tuberculosis in HIV-positive and HIV-negative inpatients in Rio de Janeiro, Brazil.: Int Conf AIDS. 1990 Jun 20-23;6(1):245 (abstract no. Th.B.493). Unique Identifier : AIDSLINE ICA6/10049390; Quinhoes EP; Morais de Sa CA; Ferreira Ramos Filho C; Weniger BG; Rodrigues LG; Heyward WL; Hospital Gaffree e Guinle, Universidade do Rio de Janeiro,; Brazil; OBJECTIVES: To compare the clinical spectrum of disease caused by Mycobacterium tuberculosis in patients with and without HIV infection, as part of a study to generate empirical data for use in developing a practical case definition for AIDS. METHODS: Among 496 medical-ward inpatients screened in 1988 and 1989 in two
Association of tuberculosis and HIV infection in Zimbabwe.: Int Conf AIDS. 1990 Jun 20-23;6(1):245 (abstract no. Th.B.494). Unique Identifier : AIDSLINE ICA6/10049490; Mahari M; Legg W; Houston S; Ray S; Chiguye W; Latif A; Mashingaidze A; Neill P; Pozniak A; Mbengeranwa L; et al; City Health, Harare, Zimbabwe; OBJECTIVES: 1. To determine the seroprevalence of HIV among TB patients. 2. To compare the clinical features of TB between HIV+ and HIV- patients. Setting: City Health treats all TB diagnosed in urban Harare pop. 900,000. METHODS: All patients treated for TB by the City TB Unit July 1988-June 1989 were eligible. Full
HIV seroprevalence in tuberculosis patients in Bahia, Brazil.: Int Conf AIDS. 1990 Jun 20-23;6(1):245 (abstract no. Th.B.495). Unique Identifier : AIDSLINE ICA6/10049590; Santos RM; Cruz A; Ribeiro TT; Badaro R; Johnson WD Jr; Federal University of Bahia, Salvador, Brazil; OBJECTIVE: To evaluate HIV seroprevalence and associated high risk activities among hospitalized tuberculosis patients. METHOD: Point prevalence sero-survey for HIV infection was performed in two reference hospitals for tuberculosis in Salvador, Bahia, Brazil . RESULTS: A total of 2
Household contacts (HC) of HIV(+) patients in Zaire with active pulmonary tuberculosis (PTB) are not at increased risk of secondary M. tuberculosis (M.tb) infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):246 (abstract no. Th.B.496). Unique Identifier : AIDSLINE ICA6/10049690; Baende E; Lelo U; Kaboto M; Willame J; Ngamboli K; Ryder R; Projet SIDA, Kinshasa, Zaire; OBJECTIVE: To determine if HIV(+) patients with PTB and HIV-induced immunosuppression and possibly a larger body burden of M.tb organisms associated with their pulmonary infection are more infectious to their HC. METHODS: All patients reporting to the CDT with a sputum smear (+) for acid-fast bacillae (AFB), radiologi
Tuberculous abscesses in AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):246 (abstract no. Th.B.497). Unique Identifier : AIDSLINE ICA6/10049790; Cerigo HS; Brau N; Simberkoff M; Flomenberg P; New York Veterans Administration Medical Center (NYVA), New York,; NY, USA; OBJECTIVE: To describe tuberculous abscesses in 5 AIDS patients out of a total of 45 patients with Mycobacterium tuberculosis (TB) infection and AIDS seen at the NYVA during the years 1988 and 1989. METHODS: Charts were reviewed for clinical and laboratory presentation, CT scans, TB cultures, treatment, and response t
Mycobacterial lymph node infection and AIDS in Sao Paulo, Brazil: Int Conf AIDS. 1990 Jun 20-23;6(1):246 (abstract no. Th.B.498). Unique Identifier : AIDSLINE ICA6/10049890; Chaves RL; Nascimento MF; Batista L; Albano A; Stocco JM; Martins NC; Sato DN; Serrazoli L; Uoki SY; Palaci M; et al; Hospital Brigadeiro, Sao Paulo, Brazil; OBJECTIVE: To determine the frequency of mycobacterial lymph node infection in patients with HIV infection, and analyze clinical and epidemiological characteristics of these patients in Sao Paulo. METHODS: One hundred and fifty six patients with HIV infection had lymph node biopsy at our hospitals during the interval
Susceptible M. tuberculosis refractory to standard therapy with progression to central nervous system involvement.: Int Conf AIDS. 1990 Jun 20-23;6(1):246 (abstract no. Th.B.499). Unique Identifier : AIDSLINE ICA6/10049990; Davis I; Acosta A; Lee S; The New York Hospital-Cornell Medical Center, New York, New York,; USA; OBJECTIVE: To review treatment failure in three AIDS patients infected with M. tuberculosis (TB) susceptible to standard therapy; lack of response to therapy and subsequent progression to neurologic involvement. METHODS: Retrospective chart review of clinical data and autopsy material. RESULTS: All cases had diagnosed
Central nervous system tuberculosis in AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):247 (abstract no. Th.B.500). Unique Identifier : AIDSLINE ICA6/10050090; Laguna F; Polo R; Saenz E; Adrados M; Puente S; Gonzalez Lahoz JM; Centro Nacional de Investigacion Clinica, Madrid, Espana; OBJECTIVE: To describe frequency and clinical picture of Central Nervous System tuberculosis (CNS-TB) in AIDS patients. METHODS: Retrospective revision of AIDS patients with TB between 1986 and 1989. Those patients with cerebrospinal fluid (CSF) cultures growing Mycobacterium tuberculosis are described in this paper.
Blood culture value in the diagnostic of the disseminated tuberculosis in AIDS patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):247 (abstract no. Th.B.501). Unique Identifier : AIDSLINE ICA6/10050190; da Bouza J; Di Lonardo M; Benetucci J; Gonzalez Montaner J; Abbate E; Corti M; Compagnucci M; Ortega G; Astarloa L; Hospital of Infectious Diseases Francisco J. Muniz, Buenos Aires; City, Argentina; OBJECTIVE: To emphasize the usefulness of the blood culture practice for mycobacterium in AIDS patients and suspicion of tuberculosis. METHODS: Among 198 AIDS patients attended between June 1983 and September 1989 at F.J. Muniz Hospital, 37 showed tuberculosis as opportunistic infection (OI), 35 men and 2 women, being
Intracranial tuberculomas in patients with AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):247 (abstract no. Th.B.502). Unique Identifier : AIDSLINE ICA6/10050290; Abos J; Graus F; Miro JM; Mallolas J; Trilla A; Mercader JM; Tolosa E; Neurology, Hospital Clinic. University of Barcelona. Barcelona.; Spain; OBJECTIVE: To evaluate the incidence of intracranial tuberculosis (IT) in patients with AIDS. METHODS: We conducted a retrospective study on 419 patients with AIDS diagnosed between 1984 and October 1989. The diagnosis of IT was established by brain biopsy or response to antituberculous therapy. RESULTS: Four (1%) of
Mycobacteria isolations from stools and intestinal biopsies from HIV (+) patients and controls in Kinshasa, Zaire.: Int Conf AIDS. 1990 Jun 20-23;6(1):247 (abstract no. Th.B.503). Unique Identifier : AIDSLINE ICA6/10050390; Colebunders R; Nembunzu M; Portaels F; Lebughe I; Lusakumunu K; Piot P; Projet SIDA, Kinshasa, Zaire; OBJECTIVE: To determine the role of mycobacteria as etiologic agent in HIV related enteritis in Africa. METHODS: Stools and intestinal biopsies were obtained in HIV (+) and HIV (-) patients without clinical evidence of M. tuberculosis infection, visiting the department of Internal Medicine in Mama Yemo Hospital, Kinsh
Cohort study of HIV infected tuberculosis patients, Nairobi, Kenya: baseline radiological features.: Int Conf AIDS. 1990 Jun 20-23;6(1):248 (abstract no. Th.B.504). Unique Identifier : AIDSLINE ICA6/10050490; Gathua S; Nunn P; Wasunna K; Kwanyah G; Omwega M; Were J; McAdam K; HIV/TB Project, Kenya Medical Research Institute, Nairobi, Kenya; OBJECTIVES: To compare radiological features of HIV associated TB with HIV-TB and assess the usefulness of chest radiology in the diagnosis of HIV infection. METHODS: Antero-posterior chest radiographs were examined from 191 patients with smear and/or culture proven TB out of 240 newly diagnosed cases of TB. RESULTS:
Chest roentgenograms in 104 HIV-positive patients with tuberculosis (TB).: Int Conf AIDS. 1990 Jun 20-23;6(1):248 (abstract no. Th.B.505). Unique Identifier : AIDSLINE ICA6/10050590; Camara CS; Santos AA; Moraes AP; Eyer-Silva WA; Morais-de-Sa CA; Basilio-de-Oliveira CA; Kischinhevski W; Camisao CC; Gaffree & Guinle University Hospital, University of Rio de; Janeiro (UNI-RIO) - Brazil; OBJECTIVE: To study radiographic patterns of pulmonary TB on chest x-rays. METHODS: We retrospectively reviewed the chest x-rays of 104 HIV+ pts. consecutively admitted at our teaching hospital with diagnosis of pulmonary and/or extrapulmonary TB. Diagnosis of TB was made either by recovery of M.tuberculosis from cult
Pulmonary tuberculosis (PT) and AIDS: chest radiographic (CR) features.: Int Conf AIDS. 1990 Jun 20-23;6(1):248 (abstract no. Th.B.506). Unique Identifier : AIDSLINE ICA6/10050690; Silva VM; Werneck E; Kritski AL; Silva RA; Costa AM; Oliveira JR; Sion F; de Sa CA; Basin A; Souza RV; et al; Instituto de Tisiologia e Pneumologia - UFRJ, Rio de; Janeiro-Brazil; OBJECTIVE: Analyze the CR of PT patients with AIDS. METHODS: We compared the CR features of 106 patients with PT and AIDS with 119 age and sex matched patients with only PT. The radiological features were divided into typical (TCR) or atypical (ACR) of adult reactivation tuberculosis. RESULTS: ACR was present in 7/119
Short course antituberculous therapy for pulmonary tuberculosis in HIV seropositive patients: a prospective controlled study.: Int Conf AIDS. 1990 Jun 20-23;6(1):248 (abstract no. Th.B.507). Unique Identifier : AIDSLINE ICA6/10050790; Mukadi Y; Perriens J; Willame JC; Kaboto M; Roscigno G; Prignot J; Portaels F; Piot P; Projet SIDA, Kinshasa, Zaire; OBJECTIVES: To compare the efficacy of short course antituberculous therapy in new cases of pulmonary tuberculosis (pTB) in HIV(+) and HIV(-) patients (pts). METHODS: Patients: HIV(+) and age/sex matched HIV(-) pts with smear and culture (+) first episodes of pulmonary TB. Treatment: daily rifampicin, INH, pyrazinamid
Treatment of tuberculosis in HIV-infected patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):249 (abstract no. Th.B.508). Unique Identifier : AIDSLINE ICA6/10050890; Zamora L; Gatell JM; Mallolas J; Guelar A; Miro JM; Soriano E; Infectious Disease Unit. Hospital Clinic. Barcelona, Spain; OBJECTIVE: To determine the relapse rate after the treatment of the acute phase of the tuberculosis in HIV infected patients. METHODS: 84 consecutive cases of tuberculosis in HIV-seropositive patients were followed-up. Sixty-nine (82%) were parenteral drug addicts, 7 (8.3%) male homosexuals, 3 (3.5%) parenteral drug a
Stevens-Johnson Syndrome associated with treatment of tuberculosis in patients with HIV infection in Tanzania.: Int Conf AIDS. 1990 Jun 20-23;6(1):249 (abstract no. Th.B.509). Unique Identifier : AIDSLINE ICA6/10050990; Sugarman J; Cegielski P; Lallinger G; Mwakyusa D; Duke University Medical Center, Durham, North Carolina, USA; Five patients undergoing treatment for tuberculosis were admitted with Stevens-Johnson Syndrome to 1 ward at Muhimbili Medical Centre, Dar-es-Salaam, Tanzania , from 6/89 to 8/89. Patients admitted to this ward represent a random 1/3 of all medical admissions to Muhimbili, which t
Isoniazid prophylaxis among patients with HIV-1 infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):249 (abstract no. Th.B.510). Unique Identifier : AIDSLINE ICA6/10051090; Wadhawan D; Hira S; Mwansa N; Tembo G; Perine PL; University Teaching Hospital, Lusaka, Zambia; OBJECTIVE: To determine efficacy of isoniazid (INH) prophylaxis in prevention of Mycobacterium tuberculosis disease in adult Zambians infected with HIV-1. METHODS: A randomised, single-blind, placebo controlled study is underway since September 1988 at the University Teaching Hospital in Lusaka, Zambia. Nonpregnant ad
Mycobacterial infections in AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):249 (abstract no. Th.B.511). Unique Identifier : AIDSLINE ICA6/10051190; Cadeo GP; El Hamad I; Rossi S; Corda L; Carosi G; Bottura F; Suter F; University of Brescia, Italy; Among 1000 HIV+ pts of our surveillance program 149 developed AIDS. We diagnosed 36 (30%) mycobacterial infections (Myc): in 20/36 (55.6%) by M.tuberculosis (BK), in 8/36 (22.2%) by M.Avium Complex (MAC), in 8/36 (22.2%) by unidentified mycobacteria (UM). 27/36 (75%) pts were IVDU (including all the 8 MAC infected), 4
Concomitant HIV and mycobacterial infection in autopsied intravenous drug users in New York City.: Int Conf AIDS. 1990 Jun 20-23;6(1):250 (abstract no. Th.B.512). Unique Identifier : AIDSLINE ICA6/10051290; Araneta MR; LaRoche E; Stoneburner RL; New York City Department of Health, New York, NY, USA; OBJECTIVE: To describe concomitant mycobacterial and HIV-1 infection among autopsied intravenous drug users (IVDU) in the New York City s Office of the Chief Medical Examiner (OCME) for deaths occurring in Manhattan and the Bronx. METHODS: Deaths of unknown or criminal causes, including narcotic use, and those occurri
Mycobacteremia in AIDS patients: results emphasizing the importance of routine blood culture.: Int Conf AIDS. 1990 Jun 20-23;6(1):250 (abstract no. Th.B.513). Unique Identifier : AIDSLINE ICA6/10051390; Schurmann D; Ruf B; Mauch H; Pohle HD; II. Department of Internal Medicine, Rudolf Virchow University; Hospital (Wedding), Freie Universitat Berlin, FRG; OBJECTIVE: To evaluate the importance of blood culture in diagnosing disseminated mycobacterioses in HIV infected patients. METHODS: Blood cultures were taken as part of a routine screening program for mycobacteria including examinations during the clinical course and at autopsy. From blood specimens buffy-coat and ly
Relationship of respiratory and GI tract colonization with Mycobacterium Avium Complex (MAC) to disseminated MAC disease in HIV infected (+) patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):250 (abstract no. Th.B.514). Unique Identifier : AIDSLINE ICA6/10051490; Benson C; Kerns E; Sha B; Glick E; Harris A; Kessler H; Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois,; USA; OBJECTIVE: To evaluate the incidence and natural history of respiratory tract (RT) and GI tract (GI-T) colonization with MAC in HIV+ patients and the relationship of colonization to development of disseminated MAC disease (D-MAC). METHODS: Review of microbiology, bronchoscopy, pathology, cytopathology, and patient rec
Clinical risk factors for disseminated Mycobacterium Avium Complex Infection (DMAC) in persons with HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):250 (abstract no. Th.B.515). Unique Identifier : AIDSLINE ICA6/10051590; Havlik JA; Horsburgh CR; Metchock B; Williams P; Thompson SE; Department of Medicine, Emory University School of Medicine,; Atlanta, GA, USA; OBJECTIVE: Because DMAC is an important source of morbidity in AIDS that may not be clinically recognized, we screened consecutive HIV-infected patients presenting to our facility to determine the prevalence of and clinical risk factors for this infection. METHODS: During 3 consecutive months blood was cultured for MA
Survival of AIDS patients with disseminated Mycobacterium Avium Complex infection (DMAC): a case-control study.: Int Conf AIDS. 1990 Jun 20-23;6(1):251 (abstract no. Th.B.516). Unique Identifier : AIDSLINE ICA6/10051690; Horsburgh CR; Havlik JA; Thompson SE; Centers for Disease Control, Atlanta, Georgia, USA; OBJECTIVE: Because previous studies suggesting decreased survival of AIDS patients with DMAC had incomplete information on patient immunologic status and followup, we performed a clinic-based, case-control study of AIDS patients with DMAC to assess the effect of DMAC on survival. METHODS: Case-patients were HIV seropo
Treatment of AIDS-related disseminated Mycobacterium Avium Complex Disease (D-MAC) with a multiple drug regimen including amikacin.: Int Conf AIDS. 1990 Jun 20-23;6(1):251 (abstract no. Th.B.517). Unique Identifier : AIDSLINE ICA6/10051790; Benson C; Pottage J; Kessler H; Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL, USA; To evaluate the response of AIDS patients with D-MAC to treatment with a multiple drug regimen including amikacin (AKN). METHODS: From 12/87-12/89, all AIDS patients evaluated by one of the investigators and diagnosed with D-MAC, defined by signs/symptoms not attributed to other pathogens and isolation of MAC from blo
Rifabutin may delay the onset of Mycobacterium Avium Complex infection (MAC) in patients with AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):251 (abstract no. Th.B.518). Unique Identifier : AIDSLINE ICA6/10051890; Siegal FP; Borenstein M; Gehan K; Campbell S; Davidson B; Weiser B; Burger H; Singer C; Gold JW; Long Island Jewish Medical Center/Albert Einstein College of; Medicine, New York, NY, USA; OBJECTIVE: To obtain preliminary information on the ability of rifabutin (ansamycin) to prevent MAC in AIDS. METHODS: 22 consecutive patients with AIDS/opportunistic infections (0I) treated with rifabutin 300-900 mg/day as an anti-HIV drug were compared retrospectively to 184 concurrent consecutive AIDS-0I patients at
Clearance of cryptosporidial infection in HIV positive men: a positive correlation with CD4 counts.: Int Conf AIDS. 1990 Jun 20-23;6(1):251 (abstract no. Th.B.519). Unique Identifier : AIDSLINE ICA6/10051990; Flanigan TP; Soave R; Kotler D; Toerner J; Case Western Reserve University, Cleveland, Ohio, USA; Cryptosporidial infection in immunocompromised patients causes chronic protracted diarrhea. In person with AIDS it is almost invariably unresponsive to treatment and often leads to death. There have been recent reports of individual HIV positive patients who have cleared cryptosporidial infection. We identified 8 HIV
Oral diclazuril therapy for cryptosporidiosis.: Int Conf AIDS. 1990 Jun 20-23;6(1):252 (abstract no. Th.B.520). Unique Identifier : AIDSLINE ICA6/10052090; Soave R; Dieterich D; Kotler D; Gassyuk E; Tierney AR; Liebes L; Legendre R; Cornell Medical Center, NY, NY, USA; OBJECTIVE: To assess the safety and efficacy of escalating doses of oral diclazuril (DCZL) in subjects with AIDS and cryptosporidial (CS) enteritis. METHODS: This double-blind, placebo-controlled, randomized study used four successive groups (50, 100, 200, 400 mg) of 12 patients (9 active 3 placebo) each. Patients too
Cryptosporidium diarrhoea in AIDS patients treated with hyperimmune bovine colostrum.: Int Conf AIDS. 1990 Jun 20-23;6(1):252 (abstract no. Th.B.521). Unique Identifier : AIDSLINE ICA6/10052190; H:ojlyng N; Henriksen SA; Gaub J; Hjelt K; Mathiesen L; Jepsen S; Ladefoged K; Tzipori S; Statens Seruminstitut, Copenhagen, Denmark; OBJECTIVE: Evaluating treatment of cryptosporidium diarrhoea with hyperimmune colostrum (titer greater than 1:1600). METHODS: Randomized, cross-over, double blind design. AIDS cases with diarrhoea and cryptosporidium in their stool were given 500 ml colostrum for 2 x 10 days. Effect was based on: Stool volume, consist
Microsporidiosis in AIDS: an update of enteritis caused by E. bieneusi and a second species, and E. cuniculi as a cause of keratoconjunctivitis.: Int Conf AIDS. 1990 Jun 20-23;6(1):252 (abstract no. Th.B.522). Unique Identifier : AIDSLINE ICA6/10052290; Orenstein J; Friedberg DN; Cali A; Kotler DP; George Washington Univ. Med. Ctr., Washington, DC, USA; OBJECTIVE: To ascertain the incidence of E. bieneusi (EB) induced diarrhea, its pattern of infection, and whether other species cause enteritis. To determine the cause of keratitis in 2 AIDS patients. METHODS: Endoscopic biopsies from 1 or more sites, including the small bowel, of 100 patients with unexplained diarrhe
Is small intestinal microsporidiosis another opportunistic infection of importance in AIDS?: Int Conf AIDS. 1990 Jun 20-23;6(1):252 (abstract no. Th.B.523). Unique Identifier : AIDSLINE ICA6/10052390; Eeftinck Schattenkerk JK; van Ketel RJ; van Gool T; Bartelsman JF; Departments of Medicine (AIDS-unit), Academic Medical Center,; Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; OBJECTIVE: To estimate the prevalence of small intestinal microsporidiosis and to define its association with chronic diarrhoea in HIV infected individuals; further to explore a possible role in non HIV-infected patients with chronic diarrhoea, using a simplified metho
The prevalence of invasive amebiasis and cysticercosis is not increased in Mexican patients dying of AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):253 (abstract no. Th.B.524). Unique Identifier : AIDSLINE ICA6/10052490; Barron-Rodriguez LP; Jessurun J; Hernandez-Avila M; Unidad de Patologia, Hospital General de Mexico SSa, UNAM, Mexico; City, Mexico; OBJECTIVE: The occurrence of infection by tropical disease agents in patients coinfected with human immunodeficiency virus (HIV) is of concern to third world countries. The information derived from the autopsy material of the General Hospital of Mexico City enabled us to examine the prevalence of specific infections i
Bacteremia in adult HIV-infected patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):253 (abstract no. Th.B.525). Unique Identifier : AIDSLINE ICA6/10052590; Weinke T; Rogler G; Rohde I; Pohle HD; Universitatsklinik Rudolf Virchow, II. Medical Clinic, Freie; Universitat Berlin, FRG; OBJECTIVE: To determine the prevalence, nature, and risk factors of bacteremia in adult HIV-infected patients with special reference to Staphylococcus aureus bacteremia. METHODS: We reviewed the charts of 536 HIV-infected patients from our hospital for the presence of bacteremia. Bacteremia was defined as the isolatio
Community-acquired bacteremia, fungemia and parasitemia in febrile adults infected with HIV in Central Africa.: Int Conf AIDS. 1990 Jun 20-23;6(1):253 (abstract no. Th.B.526). Unique Identifier : AIDSLINE ICA6/10052690; Taelman H; Bogaerts J; Batungwanayo J; Kagame A; Nyirabareja A; Kabagabo L; Rutaganira V; Rutijanwa M; Blanche P; Abdel Aziz M; et al; Departments of Internal Medicine, Microbiology, General Medicine,; Centre Hospitalier de Kigali (CHK), Rwanda; OBJECTIVE: To investigate and compare the occurrence of bacteremia, fungemia and parasitemia in febrile patients (P) with and without HIV infection. METHODS: From 05/16/89 to 06/16/89 and 09/30/89 to 10/07/89, each P admitted at CHK with fever (t degrees greater than or equal to 38 degrees C) had a detailed medical hi
Severe S.aureus (SA) infections in patients (pts) with AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):253 (abstract no. Th.B.527). Unique Identifier : AIDSLINE ICA6/10052790; Cernuschi M; Franzetti F; Lazzarin A; Esposito R; Moroni M; Clinic of Infectious Diseases, University of Milan, Italy; OBJECTIVE: To evaluate the clinical spectrum and the prevalence of methicillin-resistant S.aureus (MRSA) in clinical isolates of pts with AIDS. PATIENTS AND METHODS: Retrospective charts review of 312 pts hospitalized for AIDS-related diseases from January, 1988 to December, 1989. Twenty-eight episodes of SA infection
Central venous catheters (CVC) in AIDS: risk factors for bacterial infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):254 (abstract no. Th.B.528). Unique Identifier : AIDSLINE ICA6/10052890; Bary M; Cazala JB; Vittecoq D; Boucot I; Berche P; Bach JF; Hopital Necker, Paris, France; Infection is a more frequent complication of CVC in AIDS, than in cancer patients. OBJECTIVE: To evaluate factors influencing bacterial sepsis over a one year period (1989). METHODS: 40 CVC were surgically implanted in 31 patients: 37 tunnelized silastic dual catheters (70 cath days) and 3 single lumen implantable por
Increased carriage rate of Staphylococcus aureus among HIV-patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):254 (abstract no. Th.B.529). Unique Identifier : AIDSLINE ICA6/10052990; Weinke T; Scherer W; Rohde I; Schiller R; Fehrenbach FJ; Pohle HD; Universitatsklinik Rudolf Virchow, II. Medical Clinic,; Department of Medical Microbiology, Berlin, FRG; INTRODUCTION: An increased incidence of S. aureus bacteremia has been described in patients with AIDS. Among other factors S. aureus carriage may predispose to such infections. OBJECTIVE: To investigate the nasal and throat carriage rate of S. aureus in HIV-infected patients and its clinical consequences. METHODS: Cul
Staphylococcus aureus nasal carriage in gay men with and without HIV infection: influence of sexual behavior.: Int Conf AIDS. 1990 Jun 20-23;6(1):254 (abstract no. Th.B.530). Unique Identifier : AIDSLINE ICA6/10053090; Battan R; Raviglione MC; Wallace J; Cort S; Boyle J; Taranta A; Cabrini Medical Center, New York, NY, USA; OBJECTIVE: To assess whether the reported increased carriage rate of S. aureus in AIDS or ARC patients is related to HIV disease or to trauma from anal sex. METHODS: Swabs from the anterior nares were obtained in consecutive outpatients with known HIV status and were cultured for S. aureus with standard methods. A sel
Vancomycin prophylaxis for long term central venous catheter infections in AIDS patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):254 (abstract no. Th.B.531). Unique Identifier : AIDSLINE ICA6/10053190; Battan R; Raviglione MC; D'Amore T; Pablos-Mendez A; Raggi P; Hedni R; Cabrini Medical Center, New York City, NY, USA; OBJECTIVE: To assess the efficacy of intravenous vancomycin given perioperatively in reducing the frequency of early (within 8 days) infections of long term central venous catheters (CVC) and particularly of those due to Staphylococcus aureus in patients with acquired immunodeficiency syndrome (AIDS). METHODS: Consecu
Outcome and prevention of relapses of non typhoidal salmonella bacteremia in 55 AIDS patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):255 (abstract no. Th.B.532). Unique Identifier : AIDSLINE ICA6/10053290; Detruchis P; Jaccard A; Salmon D; Rozenbaum W; Vilde JL; Couland JP; Hopital Bichat-Claude Bernard, Paris, France; OBJECTIVES: To determine the opportunity of a maintenance therapy after non typhoidal salmonella (NTS) bacteremia, we reviewed outcome and management of NTS bacteremia in hospitalized AIDS patients (pts). METHODS: From 1982 to 1989, among 996 hospitalized AIDS pts, all pts with at least one positive blood culture (BC)
Risk factors for Campylobacter infections in men with AIDS/ARC.: Int Conf AIDS. 1990 Jun 20-23;6(1):255 (abstract no. Th.B.533). Unique Identifier : AIDSLINE ICA6/10053390; Kent C; Reingold A; Anderson G; Gordon R; Stone E; Holmberg S; University of California, Berkeley, California, USA; OBJECTIVE: To identify risk factors associated with Campylobacter infection in men with AIDS/ARC, and to determine the extent of food safety counseling among AIDS/ARC patients. METHODS: Men ages 20-59 with AIDS or ARC were enrolled in a case-control study. Cases (N=86) had culture confirmed Campylobacter infections de
Altered serologic response to natural human infection with Haemophilus ducreyi, due to HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):255 (abstract no. Th.B.534). Unique Identifier : AIDSLINE ICA6/10053490; Cameron DW; Thompson CE; Filion LJ; Ronald AR; Piot P; Ndinya-Achola JO; Plummer FA; University of Ottawa, Ottawa, Ontario, Canada; OBJECTIVE: To compare quantitative serologic reactivity to H. ducreyi during natural infection, in men with and without HIV seropositivity. METHODS: Eighty-eight men with culture-proven chancroid had serial H. ducreyi serology measured with ELISA for IgM and IgG antibody response, mean absorbancy to cutoff ratios were
Mycoplasma incognitus infection in kidneys of AIDS patients with AIDS-associated nephropathy.: Int Conf AIDS. 1990 Jun 20-23;6(1):255 (abstract no. Th.B.535). Unique Identifier : AIDSLINE ICA6/10053590; Bauer FA; Wear DJ; Angritt P; Lo SC; American Registry of Pathology, Armed Forces Institute of; Pathology, Washington, D.C., USA; OBJECTIVE: To study kidney infection in patients with AIDS by the newly identified human pathogenic mycoplasma, M. incognitus (MI). METHODS AND RESULTS: We studied renal tissues from 203 autopsies of patients with AIDS submitted to the AIDS Pathology Registry, Armed Forces Institute of Pathology. Of the 203, 20 cases
In vitro antimicrobial susceptibility testing for the newly identified pathogenic human mycoplasma - M. incognitus.: Int Conf AIDS. 1990 Jun 20-23;6(1):256 (abstract no. Th.B.536). Unique Identifier : AIDSLINE ICA6/10053690; Shyh-Ching L; Wear DJ; Hayes MM; American Registry of Pathology, Armed Forces Institute of; Pathology, Washington, D.C., USA; OBJECTIVE: Many AIDS patients were found to be infected by M. incognitus. This study is to test in vitro the susceptibility of M. incognitus to representative antibiotics and to compare the sensitivity for the previously known human pathogenic mycoplasma, M. pneumoniae, to these antibodies. METHODS: We used the method
Bacillary necropeliosis of the liver in patients with cat-scratch disease and AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):256 (abstract no. Th.B.537). Unique Identifier : AIDSLINE ICA6/10053790; Angritt P; Ishak K; Rabin L; Tuur SM; Armed Forces Institute of Pathology (AFIP), Washington D.C., USA; Cat scratch disease (CSD) is an infectious process characterized by the presence in one or more organs of a pleomorphic bacillus believed to be transmitted to humans mainly by cats. Patients with CSD who are also immunodeficient may develop a systemic, severe, form of infection which is treatable with antibiotics that
Extra-cutaneous bacillary epithelioid angiomatosis in two immunocompromised hosts. Is it cat scratch disease?: Int Conf AIDS. 1990 Jun 20-23;6(1):256 (abstract no. Th.B.538). Unique Identifier : AIDSLINE ICA6/10053890; Kemper CA; Lombard C; Deresinski S; Tompkins L; Stanford University School of Medicine, Stanford, CA, USA; OBJECTIVE: We present the clinical course and histopathology of a patient with HIV infection and disseminated bacillary epithelioid angiomatosis (BEA) with visualization of cat-scratch bacillus-like organisms (CSBLO) in visceral lesions. RESULTS: This HIV infected patient presented with fever, a single nodular cutaneo
Gram-negative bacteremias (GNB) in HIV-infected patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):256 (abstract no. Th.B.539). Unique Identifier : AIDSLINE ICA6/10053990; Yamaguchi E; Chaisson RE; Johns Hopkins University, Baltimore, MD, USA; OBJECTIVE: To study the incidence, microbiology, source, predisposing factors, clinical presentation and mortality of GNB in HIV-infected patients. METHODS: Retrospective chart review of patients admitted to the AIDS Unit, Johns Hopkins Hospital, between July 1, 1988 to December 31, 1989, with positive blood cultures
Fever of unknown origin in AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):257 (abstract no. Th.B.540). Unique Identifier : AIDSLINE ICA6/10054090; Pierone G; Lin J; Masci J; Nicholas P; Mt. Sinai Services, Elmhurst Hospital, Elmhurst, NY, USA; OBJECTIVE: To determine the nature and frequency of the processes responsible for fever of unknown origin (FUO) in AIDS. METHODS: Charts were retrospectively reviewed for patients with AIDS and unexplained fever. Patients included in the analysis had fever greater than 101 degrees F lasting more than one week during a
Primary chemoprophylaxis in AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):257 (abstract no. Th.B.541). Unique Identifier : AIDSLINE ICA6/10054190; Banhegyi D; Miskovits E; Szlavik J; Gerlei Z; Ujhelyi E; Varnai F; Institute for Infectious and Tropical Diseases, Postgrad. Med.; School, Budapest, Hungary; OBJECTIVE: Evaluation of the efficacy and benefit of Isonicid(R) prophylaxis (IP) and Fansidar(R) prophylaxis (FP) as primary chemoprophylaxis in PWA. METHODS: Patients (pts) enrolled in this study were PWA or PWH having a CD4+ cell count less than 200/mm3 and p20 antigenaemia was present. All pts had Toxoplasma antib
Evaluation of measles and rubella vaccination among HIV-infected adults.: Int Conf AIDS. 1990 Jun 20-23;6(1):257 (abstract no. Th.B.542). Unique Identifier : AIDSLINE ICA6/10054290; Sprauer M; Markowitz L; Dales L; Khoury N; Nicholson J; Stewart J; Atkinson W; Centers for Disease Control, Atlanta, Ga., USA; OBJECTIVE: Live virus measles-mumps-rubella vaccine is recommended by the Immunization Practices Advisory Committee for all eligible persons, including HIV-infected (HIV+) adults. Data are limited to the response to measles antigen among HIV+ children. The purpose of this study was to obtain data concerning response t
Clinical manifestations of HIV-1 infection among women working as prostitutes in Nairobi.: Int Conf AIDS. 1990 Jun 20-23;6(1):260 (abstract no. Th.C.543). Unique Identifier : AIDSLINE ICA6/10054390; Wambugu P; Plummer FA; Anzala AO; Gilks C; Bosire M; Ngugi EN; University of Nairobi, Nairobi, Kenya; OBJECTIVE: To determine the frequency of clinical manifestations of HIV-1 infection in a community based population of women working as prostitutes. METHODS: A community based population of women from 1 Nairobi section was established in 1985. Five hundred and thirty-nine women were initially HIV-1 positive or serocon
Use of polymerase chain reaction (PCR) in the diagnosis of pediatric HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):261 (abstract no. Th.C.544). Unique Identifier : AIDSLINE ICA6/10054490; Brandt C; Rakusan T; Joseph S; Parrott R; Sever J; Children's National Medical Center, Washington, DC, USA; OBJECTIVE: To determine the reliability of PCR in detecting pediatric HIV infection. METHODS: The study population included children known to be infected with HIV, children born to HIV-seropositive mothers and healthy uninfected adults. PCR, using SK 38/39 (gag), SK 29/30 (LTR) and/or SK 68/69 (env) HIV primers and 35
Use of PCR for an early detection of HIV genes in seronegative exposed pregnant women.: Int Conf AIDS. 1990 Jun 20-23;6(1):261 (abstract no. Th.C.545). Unique Identifier : AIDSLINE ICA6/10054590; Henrion R; Ferris S; Montagnier L; Moncany ML; Maternite Port-Royal Hopital Cochin, Paris, France; We studied by PCR the eventual infection by HIV of an heterogeneous exposed population composed of seronegative pregnant women: drug users or sexual partners of seropositive men. We designed a complete set of primers covering the entire genomes of the HIV1 and of the HIV2. They were tested for their specificity and th
Presence of the HIV detected by PCR in seronegative babies born to seropositive mothers.: Int Conf AIDS. 1990 Jun 20-23;6(1):261 (abstract no. Th.C.546). Unique Identifier : AIDSLINE ICA6/10054690; Ferris S; Sprecher S; Levy J; Montagnier L; Moncany ML; Unite d'Oncologie Virale, Institut Pasteur, Paris, France; The presence of HIV genes was studied by PCR in an homogeneous exposed population composed of 35 babies born to seropositive mothers. We designed a complete set of primers covering the entire genomes of the HIV1 and of the HIV2. They were tested for their specificity and their efficiency and they allow the detection o
Pediatric AIDS: epidemiological and clinical characteristics and survival.: Int Conf AIDS. 1990 Jun 20-23;6(1):261 (abstract no. Th.C.547). Unique Identifier : AIDSLINE ICA6/10054790; Rubini ND; Quinhoes EP; Signorini DJ; Guimaraes MD; Sion FS; Morais-de-Sa CA; Gra:ca MH; Con:calves RS; Gaffree & Guinle University Hospital, University of Rio de; Janeiro (UNI-RIO), Brazil; OBJECTIVES: To investigate the epidemiological characteristic and clinical course of children with AIDS and evaluate survival after the AIDS outcome. METHODS: From January/1986 to December/1989, 25 children with AIDS have been followed up at our immunology clinic. Patients were serologically tested for HIV-1 antibodie
Lymphocyte-associated p24 antigen: a new technique for diagnosis of HIV infection in pediatric patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):262 (abstract no. Th.C.548). Unique Identifier : AIDSLINE ICA6/10054890; Rich CC; Cory JM; Landay A; Ohlsson-Wilhelm BM; University of Illinois at Chicago, Chicago, IL, USA; OBJECTIVE: To determine the utility of assessment of lymphocyte-associated HIV-1 p24 antigen for the diagnosis of HIV infection in pediatric patients. METHODS: Small (2-4ml) peripheral blood samples (n=11) were obtained from 9 patients age 7 mo to 5 1/2 yrs. All patients were born of HIV infected women and were classi
Impact of HIV on pediatric outpatient clinic use in Kigali, Rwanda.: Int Conf AIDS. 1990 Jun 20-23;6(1):262 (abstract no. Th.C.550). Unique Identifier : AIDSLINE ICA6/10055090; Roberts J; Nsengumuremyi F; Allen S; Carlson C; Kahn J; Schwalbe J; Lepage P; Projet San Francisco, Kigali, Rwanda; OBJECTIVE: To compare outpatient health care costs for HIV+ and HIV- children in Kigali, Rwanda . METHODS: 472 HIV+ mothers and 997 HIV- mothers enrolled in a prospective study of the predictors and natural history of HIV infection in Kigali, Rwanda were offered an HIV blood test fo
Seroepidemiology of HTLV-1 infection in the Venezuelan population.: Int Conf AIDS. 1990 Jun 20-23;6(1):262 (abstract no. Th.C.551). Unique Identifier : AIDSLINE ICA6/10055190; Echeverria de Perez G; Loreto O; Lee H; Bianco N; Institute of Immunology, Central University, Caracas, Venezuela; OBJECTIVE: To evaluate the seroprevalence of HTLV-I in a population with a previously reported high rate of infection. METHODS: A total of 2.297 individuals were tested for HTLV-I antibodies by EIA (Abbott); all reactive samples were confirmed by WB (Dupont) and RIPA (Abbott). RESULTS: The individuals were grouped acc
The talking sex project: results of a randomized control study for the prevention of AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):263 (abstract no. Th.C.552). Unique Identifier : AIDSLINE ICA6/10055290; Myers T; Tudiver F; Kurtz R; Jackson E; Orr K; Rowe C; University of Toronto, Toronto, Ont., Canada; OBJECTIVE: To evaluate the effect of two models of small discussion-group education on change in knowledge and behaviour in a non-clinical study population of gay and bisexual men. METHOD: The 612 subjects were recruited from the community and assigned by randomized block design to either a single session group led by
Prevalence and temporal variation of HIV-1 in semen.: Int Conf AIDS. 1990 Jun 20-23;6(1):263 (abstract no. Th.C.553). Unique Identifier : AIDSLINE ICA6/10055390; Anderson D; Politch JA; Martinez A; Wolff H; Pudney J; Van Voorhis B; Mayer K; Saltzman S; Seage G; Horsburgh CR; Harvard Medical School, Boston, MA, USA; OBJECTIVE: Various approaches were used to detect HIV in semen from seropositive men to assess the prevalence and temporal variation of HIV in semen and associations with disease stage and genital tract inflammation (GTI). METHODS: Individual semen specimens from 56 seropositive homosexual men, and 6-7 additional samp
Prevalence of HIV in the cervicovaginal secretions of women seropositive for HIV: correlation with the clinical status and implications for heterosexual transmission.: Int Conf AIDS. 1990 Jun 20-23;6(1):263 (abstract no. Th.C.554). Unique Identifier : AIDSLINE ICA6/10055490; Henin Y; Porrot F; Montagnier L; Henrion R; Institut Pasteur, Paris, France; OBJECTIVE: This study was undertaken to detect HIV in cervicovaginal secretions of seropositive pregnant and non pregnant women. METHODS: Vaginal secretions were obtained after injection of RPMI 1640 medium (5 ml) in the vagina. The medium was recovered by aspiration, then centrifuged (800 g, 15 min) to separate the s
Sexual behavior, smoking, and HIV-1 in Haitian women.: Int Conf AIDS. 1990 Jun 20-23;6(1):263 (abstract no. Th.C.555). Unique Identifier : AIDSLINE ICA6/10055590; Halsey N; Coberly J; Boulos R; Holt E; Coreil J; Kissinger P; Brutus JR; Boulos C; The Johns Hopkins Univ., Baltimore, MD, USA; OBJECTIVE: To determine if unrecognized behavioral factors confounded the association between smoking and HIV-1. METHODS: A case-control study of women recently pregnant compared female Haitian smokers (n=83), and former smokers (n=34) with non-smokers (n=303). RESULTS: Current smokers were similar to non-smokers in a
Immunological and clinical status of PCR positive, HIV antibody negative multitransfused haemophiliacs.: Int Conf AIDS. 1990 Jun 20-23;6(1):264 (abstract no. Th.C.556). Unique Identifier : AIDSLINE ICA6/10055690; Berthier AM; Moncany M; Ferris S; Genetet N; Montagnier L; Centre Rey-Leroux 35340 La Bouexiere, France; Immunological disorders occurring in seronegative haemophiliacs, multitransfused before 1985, led us to hypothesize a possible latent infection by HIV. In this view 35 seronegative multitransfused haemophiliacs (FVIII-IX greater than 250 IU/kg/Y.) and 10 seronegative sexual partners of seropositive patients, were inve
Detection of HIV-1 infection by polymerase chain reaction (PCR) and culture in HIV-1 seronegative patients attending an emergency department.: Int Conf AIDS. 1990 Jun 20-23;6(1):264 (abstract no. Th.C.557). Unique Identifier : AIDSLINE ICA6/10055790; Quinn T; Kelen G; Meyer W; Fleetwood D; Brothers T; Kline R; NIAID, NIH, Bethesda, MD, USA; OBJECTIVE: To evaluate the prevalence of HIV-1 infection and HTLV-1 infection among intravenous (IV) drug users attending an emergency department (ED), and to assess the frequency of HIV-1 infection by PCR and/or viral culture in HIV-1 antibody negative patients. METHODS: Sera and mononuclear cells were collected from
Detection of HIV-1 infection in seronegative IVDU's by polymerase chain reaction (PCR).: Int Conf AIDS. 1990 Jun 20-23;6(1):264 (abstract no. Th.C.558). Unique Identifier : AIDSLINE ICA6/10055890; Farzadegan H; Ward L; Solomon L; Cohn S; Markham L; Vlahov D; Department of Epidemiology, The Johns Hopkins University,; Baltimore, MD, USA; OBJECTIVE: To determine the prevalence of HIV-1 proviral DNA detected by PCR technique in seronegative intravenous drug users (IVDU s). METHOD: In a prospective study of the natural history of HIV-1 infection among IVDU s, 80 participants with masked serological markers HIV-1 infection were tested for presence of HIV-
Indeterminant Western Blot assays in a cohort of homosexual men.: Int Conf AIDS. 1990 Jun 20-23;6(1):264 (abstract no. Th.C.559). Unique Identifier : AIDSLINE ICA6/10055990; Phair J; Hoover D; Wright P; Saah A; Detels R; Rinaldo C; Kaslow R; Multicenter AIDS Cohort Study, Chicago, IL, USA; OBJECTIVE: To determine the frequency and significance of non-diagnostic Western Blot (WB) reactions in homosexual men with positive and negative enzyme linked immuno-absorbent assays (ELISA). METHODS: Participants in the Multicenter AIDS Cohort Study (MACS) have been seen and serum obtained every 6 mo. since 84-85. S
A comparison of risk factors for HIV-1 and hepatitis B virus (HBV) in homosexual men.: Int Conf AIDS. 1990 Jun 20-23;6(1):265 (abstract no. Th.C.560). Unique Identifier : AIDSLINE ICA6/10056090; Koziol D; Saah A; Odaka N; Munoz A; National Institutes of Health, Bethesda, Maryland, USA; OBJECTIVE: To directly compare the risk factors for HIV and HBV prevalent and incident infections, singly and concurrently, in a single population of homosexual men. METHODS: Polychotomous multiple logistic regression was used to determine odds ratios and 95% confidence intervals for risk factors for HIV alone, HBV al
Little evidence for genital ulcerative infections as a risk factor for HIV-1 acquisition among homosexual men.: Int Conf AIDS. 1990 Jun 20-23;6(1):265 (abstract no. Th.C.561). Unique Identifier : AIDSLINE ICA6/10056190; Keet IP; Lee FK; Van Griensven GJ; Lange JM; Nahmias A; Coutinho RA; Municipal Health Service, Amsterdam, The Netherlands; OBJECTIVE: To study the role of genital ulcerative infections for acquisition of HIV-1 among homosexual men. METHODS: We studied a cohort of 1000 homosexual men in Amsterdam between 1985-1988. Among 53 HIV-1 seroconverters serological and anamnestic data were gathered regarding HSV-2 and syphilis in the 6 months befor
Longitudinal follow-up of HIV-1 discordant couples in the Baltimore MACS study.: Int Conf AIDS. 1990 Jun 20-23;6(1):265 (abstract no. Th.C.562). Unique Identifier : AIDSLINE ICA6/10056290; Palenicek JG; Fox R; Odaka N; Harris J; Hardy W; Taylor E; Margolick J; The Johns Hopkins School of Hygiene and Public Health, Baltimore,; MD, USA; OBJECTIVE: To determine ongoing sexual behaviors and changes in infection status of HIV-1 serologically discordant couples in Baltimore MACS. METHODS: Among 34 gay male couples who were initially found to be discordant for HIV-1 infection (based on results of ELISA, Western blot, viral culture and PCR tests), biologic
Recent HIV infection in men in the Army: a case-control study.: Int Conf AIDS. 1990 Jun 20-23;6(1):265 (abstract no. Th.C.563). Unique Identifier : AIDSLINE ICA6/10056390; McNeil JG; Peterman T; Renzullo P; Lasley-Bibbs V; Levin L; Walter Reed Army Institute of Research, Washington DC, USA; OBJECTIVE: To identify risks for recent HIV seroconversion. METHODS: In this ongoing case-control study at 23 sites, civilians conduct blinded, voluntary interviews of soldiers with HIV seroconversion, and HIV-matched controls. Standardized interviews focus on the interval beginning 6 months before the last HIV- test
Heterosexual cotransmission of human immunodeficiency virus (HIV) and hepatitis C virus (HCV).: Int Conf AIDS. 1990 Jun 20-23;6(1):266 (abstract no. Th.C.564). Unique Identifier : AIDSLINE ICA6/10056490; Eyster ME; Alter H; Aledort L; Hatzakis A; Goedert JJ; NCI Multicenter Study of AIDS in Hemophiliacs, Bethesda, MD USA; OBJECTIVE: To study the sexual transmission of HCV by multitransfused hemophiliacs (H) coinfected with HIV. METHODS: Sera stored frozen from 239 female sexual partners (FSP) of H from 8 U.S. centers located in PA, NY, OH and LA were tested for antibodies for HCV and HIV by EIA. 48 FSP of 46 H were tested at one center
HIV infection in children transmitted by sexual abuse.: Int Conf AIDS. 1990 Jun 20-23;6(1):266 (abstract no. Th.C.565). Unique Identifier : AIDSLINE ICA6/10056590; Di John D; Darren N; Motch S; Rigaud M; Borkowsky W; McHugh M; New York University Medical Center-Bellevue Hospital Center, New; York, New York, USA; OBJECTIVE: To describe and discuss two cases of transmission of HIV infection to children via sexual abuse. METHODS: Among the patients who present to our pediatric infectious disease clinic for HIV screening, we have identified two children who acquired HIV infection by sexual abuse. HIV infection was documented by E
Risk of HIV heterosexual transmission in women from Buenos Aires City.: Int Conf AIDS. 1990 Jun 20-23;6(1):266 (abstract no. Th.C.566). Unique Identifier : AIDSLINE ICA6/10056690; Benetucci J; da Bouza J; Multare S; Corti M; Gomez Carrillo M; Ortega G; Boxaca M; Compagnucci M; Astarloa L; Hospital of Infectious Diseases F.J.Muniz. Buenos Aires City.; Argentina; OBJECTIVE: To determine the risk of HIV heterosexual transmission in women who are unique and stable sexual partners of HIV reactive men. METHOD: A group of 100 women who made a consult at the Hospital were selected. Their ages were between 18 and 44 years old and they didn t get another factor except the risk of bein
Lack of female to male transmission in husbands of HIV infected women - Gaffree & Guinle University Hospital, Rio de Janeiro, Brazil.: Int Conf AIDS. 1990 Jun 20-23;6(1):266 (abstract no. Th.C.567). Unique Identifier : AIDSLINE ICA6/10056790; Sion FS; Santos EA; Salerno-Gon:calves R; Almeida MC; Morais-de-Sa CA; Vanderborght B; Carvalho MA; Brandao AC; Rocha JT; University of Rio de Janeiro (UNI-RIO), Brazil; OBJECTIVE: To study female to male transmission of HIV in married couples with stable sexual life. METHODS: Among 53 blood-transfused women attending our outpatient care unit concerned with AIDS or presenting symptoms suggestive of HIV infection, 29 (54, 7%) were seropositive. Eleven of these women were selected on ac
Heterosexual HIV transmission: a multicenter partner study in Mexico City.: Int Conf AIDS. 1990 Jun 20-23;6(1):267 (abstract no. Th.C.568). Unique Identifier : AIDSLINE ICA6/10056890; Sepulveda J; Hernandez M; Herrera E; Avila C; Directorate of Epidemiology, Secretariat of Health, Mexico; OBJECTIVES: To determine the risk factors associated with heterosexual HIV infection and prevent transmission between couples. METHODS: As part of a multicenter cohort study of heterosexual HIV transmission in Mexico City, we analyzed the retrospective information obtained from female partner interviews in a case-cont
Risk factors for HIV-2 infection in Guinea-Bissau.: Int Conf AIDS. 1990 Jun 20-23;6(1):267 (abstract no. Th.C.569). Unique Identifier : AIDSLINE ICA6/10056990; Harrison L; de Silva AP; Albino P; Del Castillo F; Lee-Thomas S; Gayle H; CDC, Atlanta, Georgia, USA; OBJECTIVE: To identify risk factors for HIV-2 infection among adults. METHODS: We conducted a case-control study of HIV-2 infection among patients admitted to the major hospital in Bissau, Guinea-Bissau in October 1989. Sera from 128 patients were tested for HIV-1 and HIV-2 by vir
Cervical ectopy and lack of male circumcision as risk factors for heterosexual transmission of HIV in stable sexual partnerships in Kenya.: Int Conf AIDS. 1990 Jun 20-23;6(1):267 (abstract no. Th.C.570). Unique Identifier : AIDSLINE ICA6/10057090; Moss GB; D'Costa LJ; Ndinya-Achola JO; Plummer FA; Reilly MP; Kreiss JK; University of Washington, Seattle, Washington, USA; OBJECTIVE: To determine the frequency of and risk factors for heterosexual transmission of HIV within couples. METHODS: HIV+ individuals attending a Nairobi STD clinic were enrolled in a prospective study along with their spouses. RESULTS: Of 90 couples, 39 (43%) were concordant (CON) for HIV infection. Of 51 discorda
Incidence of HIV-1 seroconversion in women with genital ulcers.: Int Conf AIDS. 1990 Jun 20-23;6(1):267 (abstract no. Th.C.571). Unique Identifier : AIDSLINE ICA6/10057190; Plourde P; Plummer FA; Pepin J; Maitha G; Ndinya-Achola JO; D'Costa L; University of Nairobi, Nairobi, Kenya; OBJECTIVE: To determine the incidence of male to female transmission of HIV-1 and to examine the risk factors which facilitate transmission. METHODS: Ninety-seven HIV-1 seronegative women presenting with a genital ulcer to a sexually transmitted disease (STD) clinic in Nairobi were interviewed with respect to sexual b
Prevalence of HIV among men and women with H.ducreyi and Neisseria gonorrhoeae infection in Nairobi, Kenya.: Int Conf AIDS. 1990 Jun 20-23;6(1):268 (abstract no. Th.C.572). Unique Identifier : AIDSLINE ICA6/10057290; Ombette JJ; Ndinya-Achola JO; Maitha G; Emonyi E; Plourde P; Temmerman M; Owili D; Plummer FA; University of Nairobi, Nairobi, Kenya; OBJECTIVE: To determine incidence and prevalence of HIV among a high risk group with H.ducreyi and Neisseria gonorrhoeae infection in Nairobi, Kenya . METHODS: We studied the epidemiology of genital ulcer (GU) and gonococcal infection (GI) among high risk groups in Nairobi. We were i
Risk factors for HIV infection among women in a low-risk population in Nairobi, Kenya.: Int Conf AIDS. 1990 Jun 20-23;6(1):268 (abstract no. Th.C.573). Unique Identifier : AIDSLINE ICA6/10057390; Hunter D; Maggwa A; Mati J; Tukei P; Solomon M; Mbugua S; Bhullar V; Mohammedali Y; Harvard University, Boston, MA, USA; OBJECTIVES: To determine factors associated with HIV seropositivity in a population of women not believed to be at high risk of HIV infection. METHODS: From Oct. 1989 - Jan. 1990, 726/762 (95%) women attending 2 Nairobi family planning clinics consented to screening for HIV and other sexually transmitted diseases (STD
Vaginal tightening agents as risk factors for acquisition of HIV.: Int Conf AIDS. 1990 Jun 20-23;6(1):268 (abstract no. Th.C.574). Unique Identifier : AIDSLINE ICA6/10057490; Dallabetta G; Miotti P; Chiphangwi J; Liomba G; Saah A; Johns Hopkins University, Baltimore, MD, USA; OBJECTIVE: To determine whether women using vaginal tightening agents (VTA) have an increased risk of HIV-1 infection. METHODS: 1482 pregnant women presenting for routine care to the antenatal clinic of a major urban hospital in Malawi were interviewed about their use of topical ag
HIV-1 seropositivity and sexual history among Rwandan women.: Int Conf AIDS. 1990 Jun 20-23;6(1):268 (abstract no. Th.C.575). Unique Identifier : AIDSLINE ICA6/10057590; Duerr A; Bulterys M; Dushimimana A; Chao A; Hoover D; Shea M; Saah A; Johns Hopkins University, Baltimore, MD, USA; OBJECTIVE: To investigate the relationship between sexually transmitted diseases (STDs), multiple partners and HIV seropositivity in Rwandan women. METHODS: 357 pregnant women were screened for HIV (ELISA, Western blot); detailed sexual histories were also obtained. RESULTS: Using women who denied a history (Hx) of an
Risk factors for HIV-1 seropositivity among rural and urban pregnant women in Rwanda.: Int Conf AIDS. 1990 Jun 20-23;6(1):269 (abstract no. Th.C.576). Unique Identifier : AIDSLINE ICA6/10057690; Bulterys M; Chao A; Saah A; Dushimamana A; Habimana P; Hoover D; Shea M; Duerr A; Johns Hopkins University, Baltimore, MD, USA; OBJECTIVE: To study risk factors associated with HIV seropositivity among rural and urban pregnant Rwandan women. METHODS: Upon consent, 357 pregnant women--193 seen at a rural and 164 seen at an urban health center Nov-Dec 1989-- were tested for HIV antibodies. A detailed questionnaire of sociodemographic variables,
HIV infection among patients in a Uganda STD clinic.: Int Conf AIDS. 1990 Jun 20-23;6(1):269 (abstract no. Th.C.577). Unique Identifier : AIDSLINE ICA6/10057790; Hellmann N; Nsubuga P; Baingana B; Mbidde EK; Hellmann SD; University of California, San Francisco, CA, USA; OBJECTIVE: To investigate the magnitude of the association between HIV infection and STDs (sexually transmitted diseases) in an adult African population. METHODS: 803 (603 males, 195 females) consecutive patients of the Mulago STD Clinic underwent a standardized STD history and physical exam between 9/1/89 and 12/31/8
Specific heterosexual risk behaviors and HIV seropositivity in a Uganda STD clinic.: Int Conf AIDS. 1990 Jun 20-23;6(1):269 (abstract no. Th.C.578). Unique Identifier : AIDSLINE ICA6/10057890; Hellmann NS; Nsubuga P; Mbidde EK; Desmond-Hellmann S; University of California, San Francisco, California, USA; OBJECTIVE: Heterosexual contact is the major route of HIV transmission in Africa. We investigated specific heterosexual practices and their association with HIV seropositivity in Ugandan STD Clinic patients. METHODS: A standardized questionnaire was administered to randomly selected patients presenting to Mulago STD C
HIV risk factors in steady male partners of Kinshasa prostitutes.: Int Conf AIDS. 1990 Jun 20-23;6(1):269 (abstract no. Th.C.579). Unique Identifier : AIDSLINE ICA6/10057990; Nzila N; Kivuvu M; Manoka AT; Edidi B; Ryder R; Laga M; Projet SIDA, Kinshasa, Zaire; OBJECTIVES: To identify HIV associated risk factors among steady male sex partners of female prostitutes. METHODS: As of December 1989, 160 steady male sex partners (SMSP) of female prostitutes attending a STD clinic were interviewed, examined and tested for HIV antibodies (ELISA + Western blot) and syphilis (TPHA and
Anti-HIV efficacy of barrier contraceptives in HIV-discordant couples.: Int Conf AIDS. 1990 Jun 20-23;6(1):270 (abstract no. Th.C.580). Unique Identifier : AIDSLINE ICA6/10058090; Feldblum PJ; Hira SK; Mukololo P; Kamanga J; Mukelabai G; Godwin S; Fortney J; Family Health International, Research Triangle Park, NC 27709 USA; OBJECTIVE: To measure the efficacy of condoms and spermicides in preventing HIV infection in seronegative sexual partners of seropositive persons. METHODS: In September 1988 we initiated a study of condom and spermicide use among the HIV-discordant couples who regularly visit the U.T.H. STD clinic. After informed cons
HIV infection in urban men in Zimbabwe.: Int Conf AIDS. 1990 Jun 20-23;6(1):270 (abstract no. Th.C.581). Unique Identifier : AIDSLINE ICA6/10058190; Bassett MT; Emmanuel JC; Katzenstein D; Latif A; Community Medicine, University of Zimbabwe, Harare, Zimbabwe; OBJECTIVE: To determine behavioral and social factors associated with HIV seropositivity in a group of urban men. METHODS: Male factory workers found to be HIV positive at blood donation formed the case group and were interviewed along with 2 previously negative donors. Repeat ELISA confirmed serological status. RESUL
HIV transmission rates and co-factors in heterosexual couples.: Int Conf AIDS. 1990 Jun 20-23;6(1):270 (abstract no. Th.C.582). Unique Identifier : AIDSLINE ICA6/10058290; Rehmet S; Staszewski S; Von Wangenheim I; Bergmann L; Helm EB; Doerr HW; Stille W; Zentrum der Inneren Medizin, Johann Wolfgang Goethe-Universitat,; Theodor-Stern-kai 7, 6000 Frankfurt/ FRG; OBJECTIVES: To investigate HIV transmission rates and co-factors for HIV transmission in heterosexual couples. PATIENTS AND METHODS: We investigated transmission rates and co-factors in 184 couples with known index person. 40 discordant couples were prospectively monitored for HIV seroconversion after unprotected sexu
Risk factors in heterosexual transmission of HIV.: Int Conf AIDS. 1990 Jun 20-23;6(1):270 (abstract no. Th.C.583). Unique Identifier : AIDSLINE ICA6/10058390; Chiodo F; Marinacci G; Costigliola P; Ricchi E; Colangeli V; University of Bologna, Institute of Infectious Diseases - Bologna; Italy; OBJECTIVE: To assess risk factors in HIV heterosexual transmission by a study on HIV infection incidence among stable partners (S.P.) of HIV infected subjects (Index Cases - I.C.). METHODS: From 1985 to 1989, we have examined 216 heterosexuals which have had a stable relationship (at least for 9 months) with HIV AB +v
Oral contraception, IUD, condom use and man to woman sexual transmission of HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):271 (abstract no. Th.C.584). Unique Identifier : AIDSLINE ICA6/10058490; Mussicco M; National Research Council ITBA Milan Italy; OBJECTIVE: To evaluate the role of contraceptive practices in man to woman HIV sexual transmission. METHODS: 368 women who were steady partners of HIV infected men were enrolled and investigated by interview and laboratory test. Data were analyzed by multivariate analysis. RESULTS: Oral contraceptive (OC) and condom u
Different susceptibility of woman and man to heterosexual transmission of HIV.: Int Conf AIDS. 1990 Jun 20-23;6(1):271 (abstract no. Th.C.585). Unique Identifier : AIDSLINE ICA6/10058590; Nicolosi A; National Council of Research, ITBA, Milan, Italy; OBJECTIVE: To evaluate the risk of man to woman and woman to man sexual transmission of HIV infection. METHODS: We performed a cross sectional study of steady partners of HIV-infected subjects (IC) attending Italian Centers for HIV infection monitoring and treatment. No subjects enrolled had risk factors for HIV-trans
Incidence of seroconversion (SC) in women who are steady partners of HIV infected men (IC).: Int Conf AIDS. 1990 Jun 20-23;6(1):271 (abstract no. Th.C.586). Unique Identifier : AIDSLINE ICA6/10058690; Saracco A; Clinic of Infectious Diseases, University of Milan, Milan, Italy; OBJECTIVE: To investigate the incidence and risk factors in man to woman sexual transmission of HIV infection. METHODS: 158 seronegative women who were steady partners of IC were followed-up for a total of 107 person/yrs. Information was collected by direct interview and laboratory tests. RESULTS: 6 women seroconverte
Sexual partners of intravenous drug users in San Francisco.: Int Conf AIDS. 1990 Jun 20-23;6(1):271 (abstract no. Th.C.587). Unique Identifier : AIDSLINE ICA6/10058790; Moore L; Padian N; Vranizan KM; Brodie B; Moss AR; University of California, San Francisco, California, USA; OBJECTIVE: To examine the risk of heterosexual transmission from intravenous drug users to their sexual partners. METHODS: We screened 1078 IVDUs in various methadone maintenance and detoxification clinics in San Francisco in 1988 and 1989. Participants are interviewed about their sexual partners, and seropositives ar
Heterosexual transmission of HIV associated with the use of smokable freebase cocaine (crack).: Int Conf AIDS. 1990 Jun 20-23;6(1):272 (abstract no. Th.C.588). Unique Identifier : AIDSLINE ICA6/10058890; Chiasson MA; Stoneburner RL; Hildebrandt DS; Telzak EE; Jaffe HW; New York City Dept. of Health, NY, NY, USA; OBJECTIVE: To determine the prevalence of and behaviors associated with HIV infection in patients at a New York City STD Clinic in an area where the cumulative incidence of AIDS in adults is 6.6/1000. METHODS: Volunteers in this ongoing study were HIV antibody tested and an interviewer administered questionnaire was u
Patterns of cocaine use in relations to HIV infection among intravenous drug users in New York City.: Int Conf AIDS. 1990 Jun 20-23;6(1):272 (abstract no. Th.C.589). Unique Identifier : AIDSLINE ICA6/10058990; Nemoto T; Brown LS; Battjes RJ; Siddiqui N; Addition Research and Treatment Corporation, Brooklyn, NY, USA; OBJECTIVE: To investigate patterns of cocaine use and its association to HIV infection among cohorts of intravenous drug users (IVDUs) in 1987 and 1988. METHOD: 440 subjects (218 in 87 and 222 in 88); 61% males; 51% Blacks, 42% Hispanics, and 7% Whites were recruited from methadone clinics in New York City. After ob
Cocaine use and HIV risk among intravenous opiate addicts.: Int Conf AIDS. 1990 Jun 20-23;6(1):272 (abstract no. Th.C.590). Unique Identifier : AIDSLINE ICA6/10059090; Amsel Z; Battjes R; Pickens R; National Institute on Drug Abuse, Rockville, Maryland, USA; OBJECTIVE: To explore increased risk for HIV infection associated with cocaine use among intravenous opiate addicts. METHODS: A nonblinded HIV seroprevalence study was conducted with intravenous opiate addicts admitted to methadone treatment in 8 U.S. cities between March 1987 and June 1989 (n=3904). Subjects were tes
Crack use and related risk factors in IVDUs in San Francisco.: Int Conf AIDS. 1990 Jun 20-23;6(1):272 (abstract no. Th.C.591). Unique Identifier : AIDSLINE ICA6/10059190; Wolfe H; Vranizan KM; Gorter RG; Cohen JB; Moss AR; University of California, San Francisco, California, USA; OBJECTIVE: To determine patterns of crack use and related high-risk behaviors in IVDUs in treatment in San Francisco. METHODS: IVDUs in methadone maintenance and detoxification treatment in San Francisco are offered anonymous HIV testing with notification of results. Here we report on 1078 IVDUs tested in 1988 and 198
HIV-1 cultures from shooting gallery needles and syringes.: Int Conf AIDS. 1990 Jun 20-23;6(1):273 (abstract no. Th.C.592). Unique Identifier : AIDSLINE ICA6/10059290; Trapido EJ; McCoy C; Chitwood D; Resnick L; University of Miami School of Medicine, Miami, Florida, USA; OBJECTIVE: To determine if HIV-1 virus could be cultured from drug paraphernalia. METHODS: As part of a follow-up to a study which determined that antibodies to the HIV-1 virus were detectable in IV drug using paraphernalia, needles and syringes were obtained from shooting galleries in three high risk areas: Miami and
Risk factors of HIV. Infection in Spanish prisons.: Int Conf AIDS. 1990 Jun 20-23;6(1):273 (abstract no. Th.C.593). Unique Identifier : AIDSLINE ICA6/10059390; Martin L; Miranda MJ; Granados A; Ministerio Justicia, Madrid, Spain; OBJECTIVE OF THE STUDY IS: to describe the risk factors which determine HIV infection in Spanish prisons in order to avoid or to reduce them. METHODOLOGY: A transversal study has been performed all over the Spanish prison population in March 1989, except Catalonia s area, which voluntarily accepted a sociosanitary int
Blood transfusion and AIDS in the Caribbean: a success story?: Int Conf AIDS. 1990 Jun 20-23;6(1):273 (abstract no. Th.C.594). Unique Identifier : AIDSLINE ICA6/10059490; Narain J; Hull B; de Gourville E; Caribbean Epidemiology Centre (PAHO/WHO), POS, Trinidad, W.I.; OBJECTIVE: To describe the status of blood transfusion associated AIDS in the Caribbean. METHODS: Data reported to the Caribbean Epidemiology Centre (CAREC) on transfusion associated (TA) AIDS cases from 19 Caribbean countries and on HIV screening to blood donors were reviewed. Only cases meeting WHO/CDC case definiti
Is the cure worse than the disease: anemia, malaria, blood transfusion, and child mortality in western Kenya.: Int Conf AIDS. 1990 Jun 20-23;6(1):273 (abstract no. Th.C.595). Unique Identifier : AIDSLINE ICA6/10059590; Lackritz E; Campbell C; Hightower A; Ruebush T; Were J; Centers for Disease Control, Atlanta, GA, USA; OBJECTIVES: To develop guidelines for the prevention of severe anemia and for the appropriate use of blood transfusion in children in malaria-endemic areas of Africa, and thus limit transfusion-related HIV transmission. METHODS: We evaluated a cohort of 2,634 children from May to December 1989 in a rural hospital in W
Transmission of HIV-1 through blood transfusions despite screening with HIVCHECK(TM).: Int Conf AIDS. 1990 Jun 20-23;6(1):274 (abstract no. Th.C.596). Unique Identifier : AIDSLINE ICA6/10059690; Naegele E; Hemed Y; Rehle T; von Sonnenburg F; Gesellschaft f. Technische Zusammenarbeit (GTZ), University of; Munich, FRG; OBJECTIVE: To evaluate the performance of HIVCHECK(TM) under field conditions and to identify possible sources of error. METHODS: The study was performed in the Mbeya Region of Tanzania where 9-10% of the blood donors are infected with HIV-1 and 80% of the blood transfusions take
Anti-HBc testing can decrease the risk of transfusion related HIV transmission by more than one third.: Int Conf AIDS. 1990 Jun 20-23;6(1):274 (abstract no. Th.C.597). Unique Identifier : AIDSLINE ICA6/10059790; Le Pont F; Massari V; Jullien AM; Costagliola D; Valleron AJ; INSERM U263, Universite Paris7, Paris, France; OBJECTIVE: To evaluate the potential of anti-HBc testing in reducing the risk of inadvertent HIV infection after blood transfusion. METHODS: Assuming a lognormal distribution for seroconversion delay and a yearly number of donations of between one and four in regular blood donors, a simulation technique is used to est
HIV antigen tests on selected blood donors.: Int Conf AIDS. 1990 Jun 20-23;6(1):274 (abstract no. Th.C.598). Unique Identifier : AIDSLINE ICA6/10059890; Das PC; de Vries AH; McShine RL; Smit Sibinga CT; Red Cross Blood Bank Groningen-Drenthe, Groningen, NL; There may be a window-phase when no evidence of antibody (Ab) but only antigen (Ag) could be demonstrable in sera. Following exclusion of 6 seropositives during 1985/86 our yearly 55,000 repeat donations did not show any seroconversion. However, during 1988/89, 2 repeat donors showed recent seroconversion. We have t
Assessment of risk for occupational HIV-1 infection in health care workers (HCW) and follow-up of HCW electing zidovudine (AZT) chemoprophylaxis.: Int Conf AIDS. 1990 Jun 20-23;6(1):274 (abstract no. Th.C.599). Unique Identifier : AIDSLINE ICA6/10059990; Fahey B; Beekmann S; Wasserman B; Fedio J; Henderson D; National Institutes of Health, Bethesda, Maryland, USA; OBJECTIVE: To assess the risk for HIV-1 infection associated with varying adverse exposures (AE) and to monitor HCW electing AZT chemoprophylaxis following AE. METHODS: Since 1983 more than 1300 NCW have participated in this longitudinal study. Exposue
HIV infection in health-care workers who are blood donors.: Int Conf AIDS. 1990 Jun 20-23;6(1):275 (abstract no. Th.C.600). Unique Identifier : AIDSLINE ICA6/10060090; Chamberland M; Petersen L; Grindon A; Busch M; Ness P; Centers for Disease Control, Atlanta, GA, USA; OBJECTIVE: To estimate the rate of HIV infection acquired by occupational transmission among heath-care workers (HCWs) who are blood donors (BDs). METHODS: Occupational information is not routinely collected for BDs. However, HCWs would be expected to comprise the majority of BDs who donate at hospitals or other healte
Longterm followup of health care workers with polymerase chain reaction and antibody testing to detect delayed seroconversion.: Int Conf AIDS. 1990 Jun 20-23;6(1):275 (abstract no. Th.C.601). Unique Identifier : AIDSLINE ICA6/10060190; Gerberding JL; Littell C; Brown A; Sande M; U. C. San Francisco, California, USA; OBJECTIVE: To evaluate the incidence of delayed seroconversion (DS) & latent infection among health care workers (HCW) occupationally exposed to HIV. METHODS: Since 1984, 721 HCW lacking established risks for HIV at SFGH were enrolled in a prospective cohort study of occupational HIV risk and tested annually/post-e
Exposure of health care workers (HCW) to blood during various procedures: results of two surveys before and after the implementation of universal precautions (UP).: Int Conf AIDS. 1990 Jun 20-23;6(1):275 (abstract no. Th.C.602). Unique Identifier : AIDSLINE ICA6/10060290; Francioli P; Saghafi L; Raselli P; Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; OBJECTIVE: To assess the frequency of blood contacts (BC) and needle-stick injuries (NSI) associated with various procedures before and one year after the implementation of universal precautions, as well as the compliance to these recommendations. METHODS: In a 1000-bed hospital, nurses of all services were asked thro
Blood and amniotic fluid contact during obstetrical procedures.: Int Conf AIDS. 1990 Jun 20-23;6(1):275 (abstract no. Th.C.603). Unique Identifier : AIDSLINE ICA6/10060390; Panlilio A; Welch B; Foy D; Parrish C; McKibben P; Perlino C; Klein L; Bell D; Centers for Disease Control, Atlanta, Georgia, USA; OBJECTIVE: To assess the nature and frequency of blood contact (BC) and amniotic fluid contact (AFC) during vaginal and cesarean deliveries (Ds). METHODS: Trained observers monitored a sample of Ds at a large, urban, public hospital from May to October 1989. Data recorded included the type of D and for each person obs
Contact with blood of patients infected with HIV among emergency care providers (ECPS).: Int Conf AIDS. 1990 Jun 20-23;6(1):276 (abstract no. Th.C.604). Unique Identifier : AIDSLINE ICA6/10060490; Marcus R; Bell D; Culver D; Centers for Disease Control, Atlanta, Georgia, USA.; OBJECTIVES: To estimate: 1) HIV seroprevalence in hospital emergency department (ED) patients in high AIDS-incidence areas in the USA; 2) frequency of blood contact (BC) experienced by ECPs, including HIV BC; and 3) efficacy of universal precautions in preventing BC. METHODS: In each of 3 cities, data were collected f
Perinatal HIV transmission despite maternal/infant AZT therapy.: Int Conf AIDS. 1990 Jun 20-23;6(1):276 (abstract no. Th.C.605). Unique Identifier : AIDSLINE ICA6/10060590; Crombleholme W; Wara D; Gambertoglio J; Dattel B; Sweet R; Prober C; University of California, San Francisco, California USA; OBJECTIVE: Report experience with AZT therapy throughout pregnancy coupled with early AZT therapy of the newborn. METHOD: Serial immunologies and F/U of HIV(+) pregnant mother on AZT including pharmacokinetics. Serial immunologies, cultures and clinic
Perinatal transmission of HIV to infants of seropositive mothers identified by prenatal screening.: Int Conf AIDS. 1990 Jun 20-23;6(1):276 (abstract no. Th.C.606). Unique Identifier : AIDSLINE ICA6/10060690; Nesheim S; Lindsay M; Sawyer M; Jones D; Muther J; Nahmias A; Emory University School of Medicine, Atlanta, Georgia, USA; OBJECTIVE: To describe perinatal transmission rates and factors which might be related to transmission of HIV in a prospectively followed population-based cohort of infants born to seropositive mothers identified by prenatal testing or testing at delivery. METHODS: Seropositive mothers were identified by routine testi
Perinatal infection with human immunodeficiency virus 1 (HIV) in Newark, New Jersey.: Int Conf AIDS. 1990 Jun 20-23;6(1):276 (abstract no. Th.C.607). Unique Identifier : AIDSLINE ICA6/10060790; Oleske J; Oxtoby M; Denny T; Goode T; Schneck M; Connor E; UMD-NJ Medical School and Children's Hospital of NJ, Newark, NJ; USA; OBJECTIVE: To assess the natural history of infants born to HIV-infected women in Newark, including the rate of perinatal transmission of HIV. METHODS: Beginning March 1987 HIV-infected mothers who delivered babies at University Hospital in Newark were invited to participate. Maternal data were collected & infants
Serological follow up study of infants born from HIV-seropositive mothers in Buenos Aires Argentina.: Int Conf AIDS. 1990 Jun 20-23;6(1):277 (abstract no. Th.C.608). Unique Identifier : AIDSLINE ICA6/10060890; Rickard E; Canizal AM; Muchinik G; De Rosa MF; Capdevilla A; Cahn P; Instituto de Investigaciones Hematologicas, Academia Nacional de; Medicina Buenos Aires, Argentina; OBJECTIVE: To evaluate the serological and clinical evolution of newborns from IVDA (85,7%) and heterosexual (14,3%) seropositive mothers. METHODS: Serum samples were tested for HIV-1 antibodies (abs) by ELISA ( Abbott Laboratories ). Samples reacting positive were tested by Immunof
Maternal-infant HIV-1 transmission (MIT) in breastfed Haitian infants.: Int Conf AIDS. 1990 Jun 20-23;6(1):277 (abstract no. Th.C.609). Unique Identifier : AIDSLINE ICA6/10060990; Halsey N; Boulos R; Holt E; Coberly J; Kissinger P; Brutus JR; Ruff A; Quinn T; Boulos C; Dept. of Int'l Health, Johns Hopkins Univ., Baltimore, MD, USA; OBJECTIVE: To determine the rate of MIT in a breastfed population and the impact on childhood survival. METHODS: The offspring of women enrolled during pregnancy were followed at 3 month intervals using standard methods. RESULTS: TABULAR DATA, SEE ABSTRACT VOLUME. No infants lost HIV-1 antibodies after 12 mos. of age
Mother-to-child transmission of HIV viruses: a cohort study in West Africa: Burkina Faso.: Int Conf AIDS. 1990 Jun 20-23;6(1):277 (abstract no. Th.C.610). Unique Identifier : AIDSLINE ICA6/10061090; Prazuck T; Malkin JE; Lechuga P; Sondo B; Masson D; Heylynck B; Ouedraogo LA; Soudre R; Cot M; Lafaix C; G.E.E.P.: Villeneuve-Saint-Georges Burkina Faso; OBJECTIVES: 1) To determine the mother to child transmission rate of HIV viruses (HIV1, HIV2, HIV1+2). 2) To assess the outcome of the disease in seropositive mothers and children according to the type of virus. METHODS: A cohort study was initiated in 1987 with systematic HIV screening and clinical examination at del
HIV-1 serology in infants born to HIV-1 infected mothers in Nairobi, Kenya.: Int Conf AIDS. 1990 Jun 20-23;6(1):277 (abstract no. Th.C.611). Unique Identifier : AIDSLINE ICA6/10061190; Datta P; Embree JE; Maitha G; Muriithi J; Ndinya-Achola JO; Kreiss JK; Plummer FA; University of Nairobi, Nairobi, Kenya; OBJECTIVE: To determine the rate of serologically determined HIV-1 infection in infants born to HIV-1 infected mothers. METHODS: Infants born to HIV-1 infected mothers at Pumwani Maternity Hospital in Nairobi, Kenya were enrolled at birth and followed at age 6 weeks, at 3, 6, 9 and
Perinatal transmission of HIV-1 in Zambia.: Int Conf AIDS. 1990 Jun 20-23;6(1):278 (abstract no. Th.C.612). Unique Identifier : AIDSLINE ICA6/10061290; Hira S; Mwale C; Kamanga J; Bhat G; Tembo G; Luo N; Perine PL; University Teaching Hospital, Lusaka, Zambia; OBJECTIVES: To determine perinatal transmission rate; to determine morbidity and mortality of HIV-1 infection in children. METHODS: A prospective study was conducted on 1954 women in labor at the University Teaching Hospital in Lusaka, Zambia . 227 (11.6%) of women were WB confirmed
Mother to child transmission of HIV infection, results of a follow up study.: Int Conf AIDS. 1990 Jun 20-23;6(1):278 (abstract no. Th.C.613). Unique Identifier : AIDSLINE ICA6/10061390; Zuccotti GV; Ravizza M; Fiocchi A; Taglioretti A; Lubelli E; Giovannini M; V Dep. Paediat., University of Milan, San Paolo Hospital, Italy; OBJECTIVE: In this study we wanted to evaluate the incidence of HIV mother to child transmission and the possible correlation between maternal immunological parameters and the development of AIDS in their children. METHODS: From 9/1/87 to 9/1/89 we have followed 46 HIV positive pregnant women (past or current intraven
Mother-to-infant transmission of HIV: predictive value of virus isolation from placental tissue and peripheral-blood mononuclear cells during pregnancy.: Int Conf AIDS. 1990 Jun 20-23;6(1):278 (abstract no. Th.C.614). Unique Identifier : AIDSLINE ICA6/10061490; Izopet J; Berrebi A; Tricoire J; Herne P; Puel J; Laboratoire de Virologie, CHU Toulouse-Purpan, France; OBJECTIVES: To investigate maternal virological markers that could predict HIV infection in infants born to seropositive mothers and to estimate the incidence of placental tissue infection in mother-to-infant HIV transmission. METHODS: 2 groups of HIV-1 seropositive mothers in CDC class II, intravenous drug addicts, w
Maternal antibodies to gp120 hypervariable loop region might control mother-to-child HIV-1 transmission.: Int Conf AIDS. 1990 Jun 20-23;6(1):278 (abstract no. Th.C.615). Unique Identifier : AIDSLINE ICA6/10061590; Rossi P; Moschese V; Tovo PA; Broliden PA; Wigzell H; Wahren B; Karolinska Institute, Stockholm, Sweden; OBJECTIVE: To define the role of maternal antibodies to selected HIV-I peptides in preventing mother-to-child transmission. METHODS: Sera from 30 HIV-I infected mothers who gave birth to 19 uninfected and 11 infected infants were collected at delivery. The children HIV-I status was determined either according to CDC d
Virus culture, polymerase chain reaction and in vitro antibody production for early diagnosis of pediatric HIV1 infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):279 (abstract no. Th.C.616). Unique Identifier : AIDSLINE ICA6/10061690; Vendrell JP; Nicolas J; Huguet MF; Serre A; Agut H; Carbachnon E; Courpotin C; Affiliation not specified; The diagnosis of HIV1 infection in infants born to HIV seropositive mothers is critical. Passively acquired maternal antibodies generally hamper the serological diagnosis. In vitro anti-HIV1 antibody production (IVAP) by peripheral blood mononuclear cells (PBMC) reflect a persistent viral antigenic stimulation and so
Maternal-infant transmission of HTLV-I infection in Haiti.: Int Conf AIDS. 1990 Jun 20-23;6(1):279 (abstract no. Th.C.617). Unique Identifier : AIDSLINE ICA6/10061790; Holt E; Wiktor S; Ruff A; Boulos R; Blattner W; Brutus JR; Kissinger P; Adrien M; Boulos C; Halsey NA; Johns Hopkins Univ., Baltimore, MD, USA; OBJECTIVE: To determine the rate of and factors associated with maternal-infant transmission of HTLV-I. METHODS: Pregnant Haitian women were screened for HTLV-I and HIV-1 (ELISA and WB). Children of HTLV-I seropositive mothers who survived to 18 months or greater were examined and tested for HTLV-I (WB). RESULTS: Of 2
Prospective study of HTLV-I transmission from mother to child in Gabon: clinical and serological follow-up.: Int Conf AIDS. 1990 Jun 20-23;6(1):279 (abstract no. Th.C.618). Unique Identifier : AIDSLINE ICA6/10061890; Delaporte E; Peeters M; Ville Y; Bedjabaga L; Ossari S; Bertheaux F; Larouze B; C.I.R.M., Gabon; OBJECTIVE: To study the natural history of HTLV-I infection from children born to seropositive mothers and to determine the rate of perinatal transmission of HTLV-I in an area where the HTLV-I seroprevalence rate is high (8%) and HIV seroprevalence rates are still relatively low (less than 1%). METHODS: Clinical and s
Progression to AIDS in HIV positive men: 5-year followup of the San Francisco General Hospital cohort.: Int Conf AIDS. 1990 Jun 20-23;6(1):279 (abstract no. Th.C.619). Unique Identifier : AIDSLINE ICA6/10061990; Krampf W; Shiboski S; Osmond D; Bacchetti P; Moss AR; University of California, San Francisco, California, USA; OBJECTIVE: 288 HIV-positive homosexual men have been followed at SFGH since 1983-4. We examined progression rates to AIDS by baseline values of prognostic markers at five years of followup or about eight years after infection. METHODS: Consenting subjects are seen at six month intervals at SFGH for physical examinatio
The Sydney AIDS project: development of AIDS in a cohort of HIV seropositive homosexual men.: Int Conf AIDS. 1990 Jun 20-23;6(1):280 (abstract no. Th.C.620). Unique Identifier : AIDSLINE ICA6/10062090; Tindall B; Cooper DA; National Centre in HIV Epidemiology and Clincal Research,; University of New South Wales, Australia; OBJECTIVE: To describe the incidence rates of AIDS and risk factors for the development of AIDS in a large cohort of homosexual men monitored for five years. METHODS: In 1984, 1057 homosexual men were enrolled in this cohort. Of these men, 414 (39%) were HIV seropositive. We examined the most antecedent information av
Relationship between AIDS latency period and survival time.: Int Conf AIDS. 1990 Jun 20-23;6(1):280 (abstract no. Th.C.621). Unique Identifier : AIDSLINE ICA6/10062190; Hessol NA; Byers R; Lifson A; O'Malley P; Cannon L; Barnhart L; Buchbinder S; Harrison J; Rutherford G; AIDS Office, San Francisco Department of Public Health,; California, USA; OBJECTIVE: To investigate the relationship between AIDS latency period (time from HIV seroconversion to first AIDS diagnosis) and AIDS survival time (AIDS diagnosis to death) in a cohort of homosexual and bisexual (H/B) men. METHODS: We identified 263 H/B men diagnosed with AIDS whose HIV seroconversion dates (ranging
The modelling of progression to AIDS: is it wise to combine different AIDS manifestations?: Int Conf AIDS. 1990 Jun 20-23;6(1):280 (abstract no. Th.C.622). Unique Identifier : AIDSLINE ICA6/10062290; Schechter MT; Craib KJ; Le TN; Montaner JS; Maynard M; Broughton S; Voigt R; O'Shaughnessy M; The Vancouver Lymphadenopathy-AIDS Study, University of British; Columbia and St. Paul's Hospital, Vancouver, Canada; OBJECTIVE: To investigate progression to the development of Kaposi s sarcoma (KS) and opportunistic infections (OI) separately in our cohort of seropositive homosexual men. METHODS: Kaplan-Meier (KM) methods were used. Time zero=seroconversion date for seroincident subjects; a lead time of 18 months was used for serop
AZT use in AIDS-free HIV-1 seropositive men in the Multicenter AIDS Cohort Study (MACS) 1987-1989.: Int Conf AIDS. 1990 Jun 20-23;6(1):280 (abstract no. Th.C.623). Unique Identifier : AIDSLINE ICA6/10062390; Graham NM; Zeger SL; Kuo V; Jacobson LP; Phair JP; Detels R; Rinaldo CR; Saah AJ; Multicenter AIDS Cohort Study, Bethesda, MD, USA; OBJECTIVE: To determine: 1. if the proportion of pre-AIDS participants (i.e., CD4 less than 200 or ARC) taking AZT is high enough to explain the 15% deficit in expected U.S. AIDS cases observed since mid-1987; 2. which factors are associated with star
AIDS risk can be predicted with CD4%, neopterin and beta-2-microglobulin only one (1) year after HIV seroconversion.: Int Conf AIDS. 1990 Jun 20-23;6(1):281 (abstract no. Th.C.624). Unique Identifier : AIDSLINE ICA6/10062490; Kramer A; Biggar RJ; Fuchs D; Wachter H; Goedert JJ; Institute of Medical Biometry, University Tubingen, FRG; OBJECTIVE: To determine if early changes in immune parameters predicted increased 5-year AIDS incidence rates. METHODS: A cohort of 131 HIV-positive homosexual men was studied from 1982-88. They consisted of 47 seroconverters, 42 prevalent positives from New York City (NYC), and 42 prevalent positives from Washington
Residual AIDS-free time and changes in CD4% in homosexual men seropositive for HIV-1.: Int Conf AIDS. 1990 Jun 20-23;6(1):281 (abstract no. Th.C.625). Unique Identifier : AIDSLINE ICA6/10062590; Munoz A; Hoover D; Wright P; Detels R; Kingsley L; Graham N; Schrager L; Phair J; Multicenter AIDS Cohort Study (MACS), Bethesda, MD, USA; OBJECTIVE: To estimate and compare transition probabilities between levels of CD4% and AIDS in homosexual men infected with HIV-1. METHODS: 2075 seropositive men followed during 1984-89 provided 12,180 pairs of observations 6-months apart while free of medications for AIDS. Transition probabilities between CD4% catego
Percentage of CD4 cells as a predictor of Pneumocystis carinii pneumonia in a cohort of homosexual men.: Int Conf AIDS. 1990 Jun 20-23;6(1):281 (abstract no. Th.C.626). Unique Identifier : AIDSLINE ICA6/10062690; Rutherford GW; Hessol NA; Lifson AR; O'Malley PM; Buchbinder SP; Holmberg SD; Department of Public Health, San Francisco, California, USA; OBJECTIVE: To determine the risk of developing Pneumocystis carinii pneumonia (PCP) in HIV-1-infected homosexual and bisexual men. METHODS: We examined the relationship between baseline percentage of CD4 cells (%CD4) and the cumulative risk of PCP, as determined by Kaplan-Meier analysis, in a cohort of homosexual and
Epidemiology and natural history of Kaposi's sarcoma (KS) and Pneumocystis carinii pneumonia (PCP).: Int Conf AIDS. 1990 Jun 20-23;6(1):281 (abstract no. Th.C.627). Unique Identifier : AIDSLINE ICA6/10062790; Winkelstein W; Fusaro RE; Sheppard HW; University of California, Berkeley, California, USA; OBJECTIVES: Compare AIDS cases presenting with KS or PCP according to: time trends of incidence; behavioral risk factors, clinical findings, and biological markers during 24 months before diagnosis. METHODS: Subjects were selected for the San Francisco Men s Health Study by area probability sampling in 1984. Data were
Progression of HIV disease during the early stages: Estimating rates of decline of CD4+ T-lymphocytes.: Int Conf AIDS. 1990 Jun 20-23;6(1):282 (abstract no. Th.C.628). Unique Identifier : AIDSLINE ICA6/10062890; Brundage J; Gardner L; McNeil J; Mayers D; Pomerantz R; Redfield R; Milazzo M; Burke D; Birx D; Oster C; et al; Walter Reed Army Institute of Research, Washington, DC, USA; OBJECTIVE: To estimate rates of decline of CD4+ T-lymphocytes in early stage HIV disease. METHODS: For this analysis, the unit of observation was the slope, the change of T4 cells from one clinical evaluation to the next (delta T4/delta months). Observed slopes were aggregated into distributions based on the T4 cell c
Evolution of lymphadenopathy in HIV-1 seropositive homosexual men and involution among those who develop AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):282 (abstract no. Th.C.629). Unique Identifier : AIDSLINE ICA6/10062990; Friedman H; Kaslow R; Goldsmith J; Hoover D; Odaka N; Odimbie O; Detels R; Multicenter AIDS Cohort Study, Bethesda, MD, USA; OBJECTIVE: To examine the natural history of HIV-induced lymphadenopathy (L), with particular attention to its involution late in HIV infection. METHODS: We quantified L at each 6 mo examination of HIV-seropositives (SPs) at entry and seroconverters (SCs). Mean number of abnormal nodes and generalized L (GL = abnormal
Evidence for a sexually transmitted cofactor for Kaposi's sarcoma in a cohort of homosexual men.: Int Conf AIDS. 1990 Jun 20-23;6(1):282 (abstract no. Th.C.630). Unique Identifier : AIDSLINE ICA6/10063090; Archibald CP; Schechter MT; Craib KJ; Le TN; Montaner JS; Willoughby B; Douglas B; O'Shaughnessy M; The Vancouver Lymphadenopathy-AIDS Study, University of British; Columbia and St. Paul's Hospital, Vancouver, Canada; OBJECTIVE: To study risk factors for the development of Kaposi s sarcoma (KS) in our cohort study of homosexual men. METHODS: A case-control design was used to compare antecedent risk factors in those developing KS relative to those developing OI. As well, Kaplan-Meier curves of KS incidence were stratified over putat
Examination of timing of potential Kaposi's sarcoma cofactor relative to HIV-1 infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):282 (abstract no. Th.C.631). Unique Identifier : AIDSLINE ICA6/10063190; Jacobson L; Munoz A; Dudley J; Grufferman S; Obrams I; Armenian H; Phair J; Multicenter AIDS Cohort Study (MACS), Bethesda, MD, USA; OBJECTIVE: Determine the timing of a possible cofactor for Kaposi s sarcoma (KS) relative to HIV-1 infection amongst HIV-1 seroconverters in the MACS, a longitudinal study of homosexual/bisexual men. METHODS: Men who have seroconverted under observation and have developed KS (cases) were each matched to 5 other seroco
European non-aggregate AIDS data set: Kaposi's sarcoma study.: Int Conf AIDS. 1990 Jun 20-23;6(1):283 (abstract no. Th.C.632). Unique Identifier : AIDSLINE ICA6/10063290; Couturier E; Lavoie G; Ancelle-Park R; Brunet JB; WHO Collaborating Centre on AIDS, Paris, France; OBJECTIVE: To analyze data on Kaposi s sarcoma (KS) collected up to March 1989 through the European Non-Aggregate AIDS Data Set (ENAADS) supplied by 12 countries to date (Czechoslovakia, France , German DR, FR Germany ,
Immunestatus as a determinant of human papillomavirus detection and its correlation with anal epithelial abnormalities.: Int Conf AIDS. 1990 Jun 20-23;6(1):283 (abstract no. Th.C.633). Unique Identifier : AIDSLINE ICA6/10063390; Melbye M; Palefsky J; Gonzales J; Ryder L; Biggar RJ; Danish Cancer Registry, Copenhagen, Denmark; An increase in anal carcinomas has been reported recently among gay men. OBJECTIVE: To characterize the role of the immunostatus and lifestyle factors on type-specific anal HPV expression and HPV s potential association with anal epithelial abnormality. METHODS: A well established cohort (initiated 1981) of 120 homose
Infection with syphilis and/or HIV among initially asymptomatic homosexual males, Boston, Ma., 1985-1989: Int Conf AIDS. 1990 Jun 20-23;6(1):283 (abstract no. Th.C.634). Unique Identifier : AIDSLINE ICA6/10063490; Mayer KH; Underdahl J; Saltzman SP; Sommers EA; Moon MW; Moye J; Fenway Community Health Center, Boston, MA, USA; OBJECTIVE: To assess the seroprevalence, seroconversion, and natural history of syphilis in relation to HIV among initially asymptomatic gay Boston males followed every 6 months in an ongoing cohort study of HIV infection (initial HIV prevalence: 25%). METHODS: HIV+ (N=74 already + and 8 seroconverters) and HIV- (N=75
The conditional incubation distribution and survival in a group of transfusion associated AIDS cases seen in Mexico City.: Int Conf AIDS. 1990 Jun 20-23;6(1):283 (abstract no. Th.C.635). Unique Identifier : AIDSLINE ICA6/10063590; Volkow P; Ponce de Leon S; Calva J; Mohar A; Hospital PEMEX, Mexico City, Mexico; OBJECTIVE: There is very little information on the incubation period of AIDS in Latin American populations. This study reports the incubation period and survival for a group of Mexican persons infected with HIV as a result of contaminated blood transfusion. METHODS: We analyzed data from 36 adult patients for whom dat
HIV progression in recipients according to donor type.: Int Conf AIDS. 1990 Jun 20-23;6(1):284 (abstract no. Th.C.636). Unique Identifier : AIDSLINE ICA6/10063690; Samson S; Busch M; Salk S; Garner J; Ward J; Perkins H; Irwin Memorial Blood Centers, San Francisco, California, USA; OBJECTIVE: Determine if AIDS progression in infected blood recipients is more rapid when the donor developed AIDS soon after donation. METHODS: As of October 1989, 538 HIV infected former donors were categorized into 3 groups: 1) developed AIDS less than 29 months (mos.) following donation; 2) developed AIDS greater t
Lack of association in anti-HIV(+) hemophiliacs between decline in CD4 and treatment with clotting factor concentrates.: Int Conf AIDS. 1990 Jun 20-23;6(1):284 (abstract no. Th.C.637). Unique Identifier : AIDSLINE ICA6/10063790; Gjerset G; Puget Sound Blood Center, Seattle, WA, USA; OBJECTIVE: To determine whether changes in CD4 counts in HIV-infected hemophiliacs are related to treatment with clotting factor concentrates. METHODS: Treatment between entry and 6-month follow-up visits was recorded and CD4 counts determined for 505 anti-HIV(+) subjects with congenital clotting disorders. Treatment
Fall of CD4 lymphocytes in HIV-1 infected patients with coagulation diseases.: Int Conf AIDS. 1990 Jun 20-23;6(1):284 (abstract no. Th.C.638). Unique Identifier : AIDSLINE ICA6/10063890; Hilgartner MW; Cornell University Medical Center, New York, New York, USA; OBJECTIVE: To determine among HIV-1 infected persons with congenital clotting disorders (CCD) whether changes in absolute CD4+ counts predict progression to AIDS. METHODS: Since 1985, 593 HIV-1 infected persons with CCD have been followed clinically at 6 month intervals for a median of 2.8 years. Lymphocyte sub-popula
In French hemophiliacs, progression to AIDS is more frequent in children and is not related to CMV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):284 (abstract no. Th.C.639). Unique Identifier : AIDSLINE ICA6/10063990; Laurian Y; Archambault MP; Verroust F; Peynet J; Dussaix E; International Hemophilia Traninig Center, Kremlin-Bicetre, France; OBJECTIVE: Determine whether the development of AIDS in hemophiliacs was related to age as claimed by Goedert et al. and CMV infection as claimed by Webster et al. METHODS: 161 persons with hemophilia (A 146, B 15) ranging in age 1-34 at the time of first HIV an
Comparison between the evolution of the HIV positive hemophiliacs and transfusion-associated cases. Bordeaux, France, 1985-1989.: Int Conf AIDS. 1990 Jun 20-23;6(1):285 (abstract no. Th.C.640). Unique Identifier : AIDSLINE ICA6/10064090; Dupon M; Bismuth MJ; Mselatti P; Lacoste D; Schmitt A; Lacut JY; Centre Hospitalier Regional Universitaire (CHRU), Bordeaux,; France; OBJECTIVE: To compare the clinical evolution of two groups of HIV patients infected with blood products (hemophiliacs [He] and transfusion-associated [Ta]) studied in the cohort study in an epidemiologic Hospital based surveillance system at the Bordeaux University Hospital since 1985. METHODS: Patients aged over 13 a
Ten year follow-up of a cohort of 111 anti-HIV seropositive haemophiliacs.: Int Conf AIDS. 1990 Jun 20-23;6(1):285 (abstract no. Th.C.641). Unique Identifier : AIDSLINE ICA6/10064190; Lee CA; Phillips AN; Elford J; Janossy G; Griffiths PD; Kernoff PB; Royal Free Hospital and School of Medicine, London NW3, England.; OBJECTIVE: To assess the natural history of HIV disease in 111 infected haemophiliacs. METHODS: Patients were reviewed at frequent intervals from the time of seroconversion (established by retrospective testing in 63 (57%) patients) until November 1989. RESULTS: The first seroconversion was October 1979 and the last w
Cumulative risk for AIDS: changing pattern of primary AIDS diagnosis in a cohort of hemophiliacs in western Pennsylvania.: Int Conf AIDS. 1990 Jun 20-23;6(1):285 (abstract no. Th.C.642). Unique Identifier : AIDSLINE ICA6/10064290; Ragni MV; Kingsley LA; University of Pittsburgh School of Medicine, Hemophilia Center of; Western Pennsylvania, Pennsylvania; OBJECTIVE: To describe the distribution of AIDS and other HIV outcomes, and the pattern of primary AIDS diagnoses (Dx) in a cohort of hemophiliacs. METHODS: A well-characterized cohort (n=84) of HIV-infected hemophiliacs from Western Pennsylvania, on whom HIV seroconversion dates are known, has been followed prospecti
Why the slower progression rate to AIDS in young HIV-infected patients?: Int Conf AIDS. 1990 Jun 20-23;6(1):285 (abstract no. Th.C.643). Unique Identifier : AIDSLINE ICA6/10064390; Phillips A; Lee CA; Elford J; Webster A; Janossy G; Kernoff PB; Royal Free Hospital and School of Medicine, London NW3, England; OBJECTIVE: To explain the slower progression rate to AIDS in young HIV infected patients. METHODS: The study of serial CD4 lymphocyte counts in a group of 248 haemophiliacs, of whom 111 were HIV infected. RESULTS: In the anti-HIV positive patients there was no difference in the rate of decline in CD4 lymphocyte count
Progression of HIV disease in intravenous drug users.: Int Conf AIDS. 1990 Jun 20-23;6(1):286 (abstract no. Th.C.644). Unique Identifier : AIDSLINE ICA6/10064490; Gorter RW; Vranizan K; Moss AR; Brodie B; Wolfe H; University of California, San Francisco, California, USA; OBJECTIVE: To evaluate markers for progression of HIV+ IVDUs in San Francisco. METHODS: 160 HIV+ heterosexual IVDUs recruited from drug treatment programs (enrolled 1987-present) are evaluated clinically and for laboratory markers and followed at San Francisco General Hospital. Data were compared with HIV+ gay men (en
Increased risk of AIDS in older intravenous drug abusers and rates of HIV seroconversion: 5-year follow-up findings from the New Jersey (NJ) intravenous drug abuser (IVDA) cohort study.: Int Conf AIDS. 1990 Jun 20-23;6(1):286 (abstract no. Th.C.645). Unique Identifier : AIDSLINE ICA6/10064590; Weiss SH; Denny TN; French J; Klein CW; Jaffee MA; Altman R; Department of Preventive Medicine, UMDNJ-New Jersey Medical; School, Newark, NJ, USA; OBJECTIVES: Assess the risk of HIV acquisition amongst previously seronegative IVDA, and evaluate risk factors for the development of AIDS amongst HIV seropositive IVDA. METHODS: AIDS and death registries, medical records, and clinical follow-up were utilized to ascertain AIDS among 341 IVDA who were HIV+ in 1984. 285
Progression to AIDS and predictors in a large cohort of injecting drug users with ARC treated with zidovudine.: Int Conf AIDS. 1990 Jun 20-23;6(1):286 (abstract no. Th.C.646). Unique Identifier : AIDSLINE ICA6/10064690; Vella S; Pezzotti P; Agresti MG; Menniti F; Guarnotta G; Rezza G; Centro Operative AIDS, Istituto Superiore di Sanita, Rome, Italy; OBJECTIVE: To estimate the risk of developing AIDS and to identify predictors of disease progression in injecting drug users (IDUs) with early or advanced ARC treated with zidovudine ( AZT ). METHODS: Data on 793 patients with ARC who started AZT treatmf
AIDS-free time after seroconversion in injecting drug users and other risk groups.: Int Conf AIDS. 1990 Jun 20-23;6(1):286 (abstract no. Th.C.647). Unique Identifier : AIDSLINE ICA6/10064790; Rezza G; Lazzarin A; Angarano G; Sinicco A; Zerboni R; Aiuti F; Pristera R; Salassa B; Barbanera M; Gafa S; et al; IMCSA, AIDS Unit, Istituto Superiore Sanita-Rome (Italy); OBJECTIVE: To describe the natural history of HIV infection in injecting drug users (IDUs); to compare the risk of developing AIDS in IDUs with that of male homosexuals (MHs) and heterosexual contacts (HTs). METHODS: 338 IDUs, 111 MHs and 73 HTs were enrolled from 12 Italian clinical facilities. Hundred and twenty-thrf
The impact of frequent injecting on the immune status of intravenous drug users (IDU).: Int Conf AIDS. 1990 Jun 20-23;6(1):287 (abstract no. Th.C.648). Unique Identifier : AIDSLINE ICA6/10064890; Mientjes G; van den Hoek JA; van Ameijden E; Schellekens PT; Roos M; Coutinho RA; Municipal Health Service, Amersterdam, The Netherlands; OBJECTIVE: To investigate the influence of hard drug use and injecting on the immune status of HIV+ and HIV- IDU. METHODS: Cross-sectional study of 282 IDU (110 HIV+ and 172 HIV-) from April 1989 to September 1989. A standard questionnaire on drug use and medical history was taken. AIDS cases and seroconverters were ef
Progression to AIDS in intravenous drug users, cofactors and survival.: Int Conf AIDS. 1990 Jun 20-23;6(1):287 (abstract no. Th.C.649). Unique Identifier : AIDSLINE ICA6/10064990; Robertson JR; Skidmore CA; Roberts JJ; Elton RA; Edinburgh Drug Addiction Study, Edinburgh, Scotland; OBJECTIVE: Survival analysis of drug users infected with HIV was carried out and relationship of progression with cofactors such as age, sex and continued drug use assessed. METHODS: In a cohort of 352 known intravenous drug users 143 were found to be positive. These individuals were followed where possible and serialf
Beta-2-microglobulin (B2M) levels in Edinburgh drug users.: Int Conf AIDS. 1990 Jun 20-23;6(1):287 (abstract no. Th.C.650). Unique Identifier : AIDSLINE ICA6/10065090; Clarkson RC; Flegg PJ; Bird AG; Brettle RP; Robertson JR; HIV Immunology Unit, Edinburgh, Scotland; OBJECTIVE: To evaluate the usefulness of B2M levels in assessing progressive HIV infection and cofactors amongst drug users (IDU) attending primary care and hospital outpatients. METHODS: An EIA was used to measure B2M levels in 100 randomly selected blood donors to establish a normal range of 0.85-2.25 mg/1 (mean+/- f
Influence of gestation on HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):287 (abstract no. Th.C.651). Unique Identifier : AIDSLINE ICA6/10065190; Berrebi A; Puel J; Tricoire J; Herne H; Pontonnier G; Services de Gynecologie-Obstetrique, Hopital la Grave, France; OBJECTIVE: In order to compare the influence of time alone to the influence of time plus pregnancy on infection with HIV, we report results of a three year follow-up of two groups of women. (A) 84 HIV antibody positive, asymptomatic, pregnant patients (42 live births, 42 medically indicated abortions) (B) 94 age and sf
Effect of pregnancy on progression of HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):288 (abstract no. Th.C.652). Unique Identifier : AIDSLINE ICA6/10065290; Bledsoe K; Olopoenia L; Barnes S; Delapenha R; Saxinger C; Frederick W; Howard University Hospital, Washington, District of Columbia, USA; OBJECTIVE: Recent reports on the effect of pregnancy on HIV disease progression have been conflicting. The present study focused on certain clinical serological and immunological parameters in HIV infected pregnant (group 1) and non-pregnant (group 2) women in an attempt to assess the risk of disease progression in thf
HIV infection as a risk factor for spontaneous first trimester abortion.: Int Conf AIDS. 1990 Jun 20-23;6(1):288 (abstract no. Th.C.653). Unique Identifier : AIDSLINE ICA6/10065390; Lopita MI; Temmerman M; Sinei SK; Plummer F; Wamola I; Piot P; University of Nairobi, Kenya; OBJECTIVE: To determine whether HIV infection and other sexually transmitted diseases (STD) are risk factors for spontaneous first trimester abortion. METHODS: A case-control study was carried out at the Dept. of OBS/GYNE, Kenyatta National Hospital, Nairobi, Kenya. 135 pregnant mothers presenting with signs and symptf
Natural history of HIV infection in female beneficiaries of the Army health care system.: Int Conf AIDS. 1990 Jun 20-23;6(1):288 (abstract no. Th.C.654). Unique Identifier : AIDSLINE ICA6/10065490; Levin LI; Brundage J; McNeil J; Milazzo M; Oster C; Craig D; McAllister C; Harrison S; Walter Reed Army Institute of Research, Washington, DC, USA; OBJECTIVE: To evaluate the effect of age and other demographic factors on HIV disease progression to the occurrence of an opportunistic infection or to death (Walter Reed (WR) Stages 6-7) in a cohort of women, controlling for initial clinical stage. METHODS: Since 1985, we have identified 139 seropositive women who cof
Patterns of pregnancy and reproductive morbidity among HIV-infected women in the United States Army: a retrospective cohort study.: Int Conf AIDS. 1990 Jun 20-23;6(1):288 (abstract no. Th.C.655). Unique Identifier : AIDSLINE ICA6/10065590; Lasley-Bibbs V; Renzullo P; Goldenbaum M; Horton J; McNeil J; Walter Reed Army Institute of Research, Washington, DC, USA; OBJECTIVE: Surveillance of HIV infection in women of childbearing age, by heel stick and/or cord blood analyses of newborns, is an important part of the national effort to measure the presence of HIV infection in the general US population. This surveillance may potentially underestimate HIV seroprevalence if, in fact,f
Mortality and HIV1 infection rates in infants born to seropositive mothers: a cohort study, Brazzaville, Congo.: Int Conf AIDS. 1990 Jun 20-23;6(1):289 (abstract no. Th.C.656). Unique Identifier : AIDSLINE ICA6/10065690; Lallemant M; Lallemant-Le Coeur S; Cheynier D; Nzingoula S; Larouze B; ORSTOM S/URB, Paris/Brazzaville, Congo; OBJECTIVE: To evaluate the mortality rate in infants born to HIV1 positive and negative mothers respectively and the infection rate in the former group. SUBJECTS AND METHODS: Follow up of 64 babies born to seropositive mothers compared to 124 babies born to seronegative control mothers. Mean follow up: 24 months (18-2f
Morbidity and mortality in the first 30 months of life in 477 infants born to seropositive mothers in Zaire.: Int Conf AIDS. 1990 Jun 20-23;6(1):289 (abstract no. Th.C.657). Unique Identifier : AIDSLINE ICA6/10065790; Manzila T; Nsa W; Kabagabo U; Mosengo M; Binyingo E; Ryder R; Projet SIDA, Kinshasa, Zaire; OBJECTIVE: To describe the morbidity and mortality in the first 30 months of life in children born to HIV(+) mothers and in children born to age-matched HIV(-) mothers. METHODS: Deaths and all episodes of illness in 120 children (Group I) with HIV(+) mothers and perinatally-acquired HIV infection (PI) (HIV IgG at 12/1f
Morbidity and mortality in successive birth cohorts of children and their HIV(+) mothers in Zaire.: Int Conf AIDS. 1990 Jun 20-23;6(1):289 (abstract no. Th.C.658). Unique Identifier : AIDSLINE ICA6/10065890; Nsuami M; Badi N; Mundele L; Nzobwo B; Kashamuka M; Ryder R; Projet SIDA, Kinshasa, Zaire; OBJECTIVES: To better define HIV-induced maternal risk factors associated with early childhood morbidity (MB) and mortality (MT) including perinatally-acquired HIV infection (PI). METHODS: 249 HIV(+) mothers (MO) and 310 age-matched HIV(-) MO were enrolled in 1986-87 in a prospective cohort study at the time they presf
Natural history of HIV-1 infection in African children. A prospective cohort study in Rwanda.: Int Conf AIDS. 1990 Jun 20-23;6(1):289 (abstract no. Th.C.659). Unique Identifier : AIDSLINE ICA6/10065990; Lepage P; Van de Perre P; Msellati P; Hitimana DG; Van Goethem C; Kestelyn P; Stevens AM; Nsengumuremyi F; Serufilira A; Dabis F; Departments of Pediatrics, Obs/Gyn & Ophthalmology, Centre; Hospitalier de Kigali (CHK), Rwanda; OBJECTIVE: 1) To identify, over a 2-year period, the mother-to-child transmission rate of HIV-1 infection and 2) to describe the natural history of HIV-1 infection in children. MATERIAL: A prospective cohort-study consisting of 218 infants born to HIV-1 + mothers (Group 1) and 218 infants born to HIV-1 - mothers (Grouf
Epidemiology and natural history of HIV infection in children. Results from the Italian Multicentre Study on 1316 subjects.: Int Conf AIDS. 1990 Jun 20-23;6(1):290 (abstract no. Th.C.660). Unique Identifier : AIDSLINE ICA6/10066090; Tovo PA; de Martino M; Italian Multicentre Study, Italy; The Italian Register for HIV infection in children was instituted in 1985 by the Immunology Study Group of the Italian Association of Pediatrics. By the end of September 1989, 1316 children with proven infection or born to HIV+ mothers had been recorded by the 70 participating centers. 678/1218 perinatally exposed chif
Incubation time for AIDS among homosexual and pediatric cases.: Int Conf AIDS. 1990 Jun 20-23;6(1):290 (abstract no. Th.C.661). Unique Identifier : AIDSLINE ICA6/10066190; Costagliola D; Laporte A; Chevret S; Valleron AJ; INSERM U 263, Universite Paris 7, Paris, France; OBJECTIVE: To assess the incubation time of developing AIDS in homosexual and pediatric populations and compare them to the incubation time in transfusion recipients (who were already studied and for which the 90% confidence interval of the median was found to be 4.4 years - 9 years). METHODS: Cases were those reportef
Progression of HIV - disease: study of 86 individuals by a new staging system. (WHO, Geneva, 1989).: Int Conf AIDS. 1990 Jun 20-23;6(1):290 (abstract no. Th.C.662). Unique Identifier : AIDSLINE ICA6/10066290; Cahn P; Perez H; Casiro A; Grinberg N; Muchinik G; Bouzas M; Htal Fernandez, Buenos Aires-Argentina; OBJECTIVE: To study progression of HIV disease using a new staging system. METHODS: We performed a retrospective analysis of 86 clinical records belonging to HIV + patients (pts), examined in a 6 - monthly based schedule, with last examination in 1989. Pts. were classified in the following stages: asymptomatic (A), pef
Prognostic value of lymphnode biopsy in HIV infection: a long-term follow-up.: Int Conf AIDS. 1990 Jun 20-23;6(1):290 (abstract no. Th.C.663). Unique Identifier : AIDSLINE ICA6/10066390; Vago L; Antonacci CM; Berta L; Boldorini R; Cinque P; Castagna A; Cristina S; Costanzi G; Lazzarin A; Moroni M; et al; University of Milan, Milan, Italy; OBJECTIVE: To assess the prognostic value of the histological findings observed in lymphnode biopsies of patients (pts) at different stages of HIV infection. METHODS: We studied the lymphnodes of 121 HIV infected pts, biopsied between 1982 and 1989, and their clinical evolution for a median period of 29 months (mos) (f
Relevance of antibody response to HIV-1 non-structural proteins for understanding the pathogenesis and progression of infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):291 (abstract no. Th.C.664). Unique Identifier : AIDSLINE ICA6/10066490; Reiss P; Lange JM; Dekker J; De Wolf F; De Ronde A; Debouck C; Goudsmit J; Department of Medicine, Academic Medical Center, Amsterdam, The; Netherlands; OBJECTIVE: To study associations between antibody (Ab) responses to HIV-1 nef-, rev-, tat-, vpu-, vpr-, and protease proteins and the clinical course and pathogenesis of HIV-1 infection in vivo. METHODS: Ab to E.coli-produced HIV-1 nef, rev, tat, vpu, vpr, and protease proteins was determined by EIA in sera, taken seqf
Complete binding of p24 antigen may be a successful response to HIV-1 infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):291 (abstract no. Th.C.665). Unique Identifier : AIDSLINE ICA6/10066590; Detels R; Nishanian P; English P; Stehn S; Fahey JL; L.A. Multicenter AIDS Cohort Study (MACS) Center, UCLA Schools of; Public Health and Medicine, Los Angeles, California, USA; OBJECTIVE: To determine the relationship of bound and free p24 antigen with likelihood of developing AIDS. METHODS: Sera from four hundred randomly selected seropositive men were tested for the presence of the p24 antigen before and after pH 2.5-3.0 pretreatment with 0.5 N HC1 acid to release p24 antigen bound in immuf
Oral candidiasis in HIV infection: Progression by type of clinical presentation.: Int Conf AIDS. 1990 Jun 20-23;6(1):291 (abstract no. Th.C.666). Unique Identifier : AIDSLINE ICA6/10066690; Greenspan D; Dodd C; Westenhouse J; Feigal DW; Greenspan JS; Oral AIDS Center, Univ. of Calif., San Francisco, CA, USA; OBJECTIVE: To determine progression from oral candidiasis to AIDS by type of clinical presentation. METHODS: One hundred eighty-seven patients referred to the Oral AIDS Center between 1981 and 1989 with candidiasis on first exam were followed prospectively to the development of AIDS. Patients were categorized by theirf
Predictive markers for AIDS in children with hemophilia.: Int Conf AIDS. 1990 Jun 20-23;6(1):291 (abstract no. Th.C.667). Unique Identifier : AIDSLINE ICA6/10066790; Caussy D; Hilgartner MW; Cohen AR; Bray GL; Aledort LM; Goedert JJ; NCI Multicenter Study of AIDS in Hemophilia, Bethesda Maryland; USA; OBJECTIVE: To determine which laboratory markers best predict the onset of AIDS among 281 hemophilic children and adolescents. METHOD: We prospectively evaluated subjects who developed HIV antibodies before age 18. AIDS incidence was calculated from estimated dates of seroconversion for the following markers; first CDf
Natural history of immune activation in HIV infection: serum beta-2 microglobulin (B2M) and neopterin prior to the development of AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):292 (abstract no. Th.C.668). Unique Identifier : AIDSLINE ICA6/10066890; Fahey JL; Taylor JM; Detels R; Hofmann B; Stehn S; Rinaldo C; Munoz A; Schrager L; Huprikar J; Graham N; et al; Multicenter AIDS Cohort Study, Los Angeles, CA., USA; OBJECTIVE: To characterize the course of immune activation (B2M and neopterin) and immune deficiency (CD4 T cell levels) changes in the 2 or more years prior to development of AIDS. METHODS: 201 men who developed AIDS after 2 or more years of serial observations in the MACS study and a matched control population who df
Predictors of progression to AIDS in the Toronto sexual contact study.: Int Conf AIDS. 1990 Jun 20-23;6(1):292 (abstract no. Th.C.669). Unique Identifier : AIDSLINE ICA6/10066990; Coates R; Farewell V; Raboud J; Read S; Calzavara L; Major C; McLaughlin B; Fanning M; Shepherd F; MacFadden D; et al; University of Toronto, Toronto, Canada; OBJECTIVE: To investigate the relationship between certain clinical, laboratory, and therapeutic variables and progression to AIDS. METHODS: Since 1984, a cohort of male sexual contacts of men with HIV disease has been monitored, quarterly, with various laboratory tests, HIV serology, clinical examinations, and the cof
Evaluation of HIV p24 antibody levels, determined with a flow cytometric immunoreactive bead (IRB) assay, in predicting disease progression.: Int Conf AIDS. 1990 Jun 20-23;6(1):292 (abstract no. Th.C.670). Unique Identifier : AIDSLINE ICA6/10067090; Scillian J; McHugh T; Wang J; Sheppard H; Ascher M; Stites D; Dept. of Laboratory Medicine, UCSF, San Francisco, CA, USA; OBJECTIVE: To evaluate anti-p24 levels measured by IRB assay to predict HIV disease progression. METHODS: Uniform, 5 mum polystyrene beads coated with rDNA-produced p24 (Chiron) were incubated with test sera (1:1000 & 1:50000), washed and labeled with phycoerythrin labeled anti-human IgG. Beads were then analyzed f
In vitro production, membrane expression, and serum levels of SIL-2R in HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):292 (abstract no. Th.C.671). Unique Identifier : AIDSLINE ICA6/10067190; Jackson AL; Hofmann B; Cumberland W; Nishanian P; Rezai A; Detels R; Fahey JL; Becton-Dickinson, Mountain View, California, USA; OBJECTIVE: The purpose of this study was to study the origin of the lymphocyte activation marker SIL-2R in vitro, to characterize the change in serum SIL-2R, and cell surface IL-2R after HIV seroconversion and later in the infection. METHODS: SIL-2R was measured by ELISA using Becton Dickinson reagents. Cell surface I
Evaluation of beta-2-microglobulin and neopterin as prognostic marker in HIV disease.: Int Conf AIDS. 1990 Jun 20-23;6(1):293 (abstract no. Th.C.672). Unique Identifier : AIDSLINE ICA6/10067290; Karlsson A; Holmberg V; Sandstrom E; The Gay Men's Health Clinic, Sodersjukhuset, Stockholm, Sweden; OBJECTIVE: To elucidate the usefulness of Beta-2-microglobulin (beta2m) and Neopterin in predicting disease progression in HIV disease. METHODS: A total of 1198 frozen serum samples, collected during 1983-88 in Stockholm from 185 homo- and bisexual men who were or turned HIV seropositive, were analyzed for beta2m and
Development of immune response to HIV p24 protein.: Int Conf AIDS. 1990 Jun 20-23;6(1):293 (abstract no. Th.C.673). Unique Identifier : AIDSLINE ICA6/10067390; McRae B; Goudsmit J; Sheppard H; Lange J; Ascher M; Allain JP; Abbott Laboratories, N Chicago, IL, USA; OBJECTIVE: Determine the spectrum of IgG immune response (IR) to p24 HIV protein in seroconverters. Evaluate the clinical significance of p24 antibody (Ab) titer. METHODS: Semiquantitation of p24 Ab using recombinant p24 as capture and probe. Titers are determined by the intercept of a dilution curve of each sample an
Detection of HIV-1 genomic sequences and distinct changes in CD4+ and CD8+CD38+ compartment size precede seroconversion.: Int Conf AIDS. 1990 Jun 20-23;6(1):293 (abstract no. Th.C.674). Unique Identifier : AIDSLINE ICA6/10067490; Yagi MJ; Joesten ME; Wallace J; Bekesi JG; Department of Neoplastic Diseases, Mt. Sinai School of Medicine,; NY, NY, USA; OBJECTIVE: To identify the earliest indicators of HIV-1 infection and clinical progression to AIDS. METHODS: Homosexual men at high risk to HIV-1 infection as determined by life style, were serially tested every 4 months since 1984 for anti-HIV-1 Ab, viral replication in tissue culture (TC), immune phenotyping and ass
Interaction between HIV-1 infection and smoking on CD4 lymphocyte count.: Int Conf AIDS. 1990 Jun 20-23;6(1):293 (abstract no. Th.C.675). Unique Identifier : AIDSLINE ICA6/10067590; Park LP; Munoz A; Armenian H; Margolick J; Giorgi JV; Ferbas J; Bauer K; Kaslow RA; Fahey JL; Multicenter AIDS Cohort Study (MACS), Bethesda, MD, USA; OBJECTIVE: To investigate the interaction between HIV-1 infection and smoking on the number of CD4 lymphocytes in the seroconverter sub-population of the MACS cohort. METHODS: 285 participants in the MACS cohort were seroconverters whose date of seroconversion (SC) was known within plus or minus 4 months. These 285 me
Genetic susceptibility to progression to AIDS following HIV-1 infection: the San Francisco men's health study.: Int Conf AIDS. 1990 Jun 20-23;6(1):294 (abstract no. Th.C.676). Unique Identifier : AIDSLINE ICA6/10067690; Louie L; Newman B; King MC; School of Public Health, University of California, Berkeley, CA,; 94720, USA; OBJECTIVE: To test whether host genotype influences disease progression to AIDS in HIV-1 infected persons. METHODS: We have extracted DNA from blood samples of 104 HIV seropositive Caucasian men in the following three clinical groups: 1) asymptomatic for at least 2 years (n = 29); 2) persistently symptomatic but witho
Serum copper and zinc levels predict progression to AIDS independently of CD4 level.: Int Conf AIDS. 1990 Jun 20-23;6(1):294 (abstract no. Th.C.677). Unique Identifier : AIDSLINE ICA6/10067790; Sorensen D; Graham NM; Odaka N; Brookmeyer R; Willett W; Polk BF; Johns Hopkins School of Hygiene and Public Health, Baltimore, MD,; USA; OBJECTIVE: To determine if serum copper and zinc levels are associated with HIV-1 seropositivity and progression to AIDS in healthy gay men. METHODS: Frozen serum samples of 54 asymptomatic HIV-seropositives who later progressed to AIDS, 54 asymptomatic matched seropositives who did not progress to AIDS and 54 seroneg
Chronic depression predicts CD4 decline over a five year period in HIV seropositive men.: Int Conf AIDS. 1990 Jun 20-23;6(1):294 (abstract no. Th.C.678). Unique Identifier : AIDSLINE ICA6/10067890; Kemeny ME; Duran R; Taylor SE; Weiner H; Visscher B; Fahey JL; UCLA School of Medicine, Los Angeles, California, USA; OBJECTIVE: The goal of the study was to determine if chronic depression in HIV-1 seropositive gay men predicted changes in immune markers of HIV progression over a 5 year period. METHODS: Participants in the UCLA Multicenter AIDS Cohort Study (MACS) hive filled out the CES-Depression scale and have had blood drawn for
Does infection with hepatitis B virus or vaccination with plasma-derived hepatitis B vaccine accelerate progression to AIDS?: Int Conf AIDS. 1990 Jun 20-23;6(1):294 (abstract no. Th.C.679). Unique Identifier : AIDSLINE ICA6/10067990; Buchbinder S; Hessol N; Lifson A; O'Malley P; Barnhart L; Bodecker T; Cannon L; Rutherford G; Hadler S; AIDS Office, Department of Public Health, San Francisco, CA, USA; OBJECTIVES: To determine whether acute or chronic hepatitis B (HB) infection or receipt of plasma-derived HB vaccine after HIV seroconversion (SC) accelerates progression to AIDS. METHODS: From 1978-1980, we enrolled 6,706 homosexual and bisexual men attending a municipal sexually transmitted disease clinic in studies
CMV is not a cofactor in progression of HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):295 (abstract no. Th.C.680). Unique Identifier : AIDSLINE ICA6/10068090; Drew WL; Perkins H; Garner J; Miner R; Mount Zion Hospital and Medical Center, San Francisco,; California, USA; OBJECTIVE: In vitro cytomegalovirus ( CMV ) and other herpesviruses may enhance HIV replication. To assess the clinical relevance of this observation, 45 patients who acquired HIV infection from blood transfusion have been foll
Update on coinfection with HIV & HTLV-I in Trinidad.: Int Conf AIDS. 1990 Jun 20-23;6(1):295 (abstract no. Th.C.681). Unique Identifier : AIDSLINE ICA6/10068190; Bartholomew C; Cleghorn F; Hull B; Battoo K; Diaz C; Blattner W; The University of the West Indies/CAREC, Port of Spain, Trinidad; OBJECTIVE: To determine whether HTLV-I may act as a co-factor for the development of AIDS. METHODS: A prospective study of 34 homosexual men who were singly infected with HIV and 6 who were doubly infected with HIV and HTLV-I has been in progress since January 1984. HTLV-I is an old endemic virus in
Viral co-factors in the development of clinical symptomatology of HIV-infected subjects: Int Conf AIDS. 1990 Jun 20-23;6(1):295 (abstract no. Th.C.682). Unique Identifier : AIDSLINE ICA6/10068290; Giraldo G; Beth-Giraldo E; Gallo RC; Serwadda D; Katangole-Mbidde E; Buonaguro FM; Tamburini M; Ist. Naz. Tumori Fond. Pascale, Naples, Italy; OBJECTIVE: To determine the in vivo effect of multiple herpesviruses infections, in compromising the immune system and/or their synergistic action in HIV-infected individuals. METHODS: Cross-sectional quantitative analyses of antibody prevalence to EBV, CMV , HHV
Cancer trends associated with increasing incidence of AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):295 (abstract no. Th.C.683). Unique Identifier : AIDSLINE ICA6/10068390; Rabkin CS; Biggar RJ; Horm J; NCI, Bethesda, MD, USA; OBJECTIVE: To determine which cancers have increased in incidence with the HIV epidemic and to quantitate the excess cancer burden due to HIV infection. METHODS: The Surveillance, Epidemiology and End Results (SEER) Program registers all incident cancers in San Francisco (SF) and 8 other geographic areas comprising 10
Progressive multifocal leukoencephalopathy (PML) and HIV infection, San Francisco, 1981-1989.: Int Conf AIDS. 1990 Jun 20-23;6(1):296 (abstract no. Th.C.684). Unique Identifier : AIDSLINE ICA6/10068490; Gillespie S; Chang Y; Lemp G; Arthur R; Buchbinder S; Steimle A; Baumgartner J; Rando T; Neal D; Rutherford G; et al; Centers for Disease Control, Atlanta GA, USA; OBJECTIVE: To describe the epidemiology of AIDS-related PML and to determine the seroprevalence of JC virus (JCV), an etiologic agent of PML, in HIV-infected individuals. METHOD: We compared AIDS-related PML cases reported to SFDPH to reported AIDS cases without PML. We also compared unreported PML cases identified th
Study for the detection of antibodies and follow-up of seropositives subjects to HIV and AIDS patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):296 (abstract no. Th.C.685). Unique Identifier : AIDSLINE ICA6/10068590; Martin R; Machado F; Menendez J; Zamora F; AIDS Research Laboratory, Cuba; OBJECTIVE: Determination of the seroprevalence of HIV and contribute to a proper follow-up of subjects infected with this virus. METHODS: More than 6 million subjects from different groups of population, including those with high-risk conduct, were studied for HIV-1. This work included also 30,931 subjects for the stu
Correlation between in vivo HIV-2 replication markers and the clinical stage of infection in seropositive people from Guinea-Bissau (West Africa).: Int Conf AIDS. 1990 Jun 20-23;6(1):296 (abstract no. Th.C.686). Unique Identifier : AIDSLINE ICA6/10068690; Canas-Ferreira W; Costa C; Pinto AS; Champalimaud J; Mansinho K; Dias F; Silva PA; Prieto E; Sousa R; Araujo C; et al; Inst. Hyg. Tropical Medicine, New University of Lisbon, Portugal; OBJECTIVE: The objective is to determine a possible correlation between the time of appearance of HIV-2 replication markers and its clinical significance. METHODS: A group of 130 individuals were serially studied during a follow-up period of 36 months (1986-1989). Sera collected in 1986, 1988 and 1989 were tested by E
AIDS mortality trends among homosexual/bisexual men.: Int Conf AIDS. 1990 Jun 20-23;6(1):296 (abstract no. Th.C.687). Unique Identifier : AIDSLINE ICA6/10068790; Hersh B; Byers R; Karon J; Buehler J; Centers for Disease Control (CDC), Atlanta, Georgia, USA; OBJECTIVE: To describe mortality and survival trends for homosexual/bisexual men with AIDS in the United States , relative to trends in AIDS cases. METHODS: We analyzed national surveillance data on AIDS incidence, deaths, and survival for 37,689 homosexual/bisexual men diagnosed with A
AIDS-familiarity and in-hospital mortality for patients with initial episode of Pneumocystis carinii pneumonia (PCP) in VA hospitals (1986-1989).: Int Conf AIDS. 1990 Jun 20-23;6(1):297 (abstract no. Th.C.688). Unique Identifier : AIDSLINE ICA6/10068890; Bennett CL; Bennett W; Gertler P; Kanouse D; Guze PA; UCLA School of Medicine, CA, USA; OBJECT: We evaluated both time trends and the relation of familiarity with PCP and in-hospital mortality for patients (pts) in the 93 VA hosps. METHODS: We identified all pts with first episode PCP by reviewing all VA computerized discharge abstracts for 1986 to 1989 (n=4 million). Hosps were subgrouped according to (
Diagnosis at death: an indicator of failure or success?: Int Conf AIDS. 1990 Jun 20-23;6(1):297 (abstract no. Th.C.689). Unique Identifier : AIDSLINE ICA6/10068990; Conti L; LaLota M; Lieb S; Gill J; Sims J; Witte JJ; Department of Health and Rehabilitative Services, Tallahassee,; FL, USA; OBJECTIVE: To identify factors related to the time of diagnosis of AIDS cases in Florida, a state with greater than 10,000 cases. METHODS: Adult cases diagnosed at death (DXD) were compared to cases diagnosed while alive (DXA). Odds ratios (OR) and 95% confidence intervals (CI) were calculated for differences in race,
Survival with AIDS in Massachusetts, 1981-1988.: Int Conf AIDS. 1990 Jun 20-23;6(1):297 (abstract no. Th.C.690). Unique Identifier : AIDSLINE ICA6/10069090; Seage GR; Oddleifson S; Carr E; Shea B; Makarewicz L; Boston Department of Health and Hospitals, Boston, MA. USA; OBJECTIVE: To determine survival time after diagnosis with Centers for Disease Control (CDC)-defined AIDS, and to identify predictors of survival. METHODS: All adult MA resident cases meeting the CDC definition for AIDS, and reported to the Massachusetts AIDS Surveillance Program (MASP), through 12/88 were included in
Survival status of cases from the N.J. AIDS registry.: Int Conf AIDS. 1990 Jun 20-23;6(1):297 (abstract no. Th.C.691). Unique Identifier : AIDSLINE ICA6/10069190; Crystal S; Schiller N; Altman R; Costa S; Massey J; Beals J; Merzel C; Dulberg E; AIDS Research Group, Inst for Health, Rutgers Univ, New Brunswick; 08903, NJ, USA; OBJECTIVE: To better ascertain survival status in AIDS, specifically cases in an AIDS case registry listed as not known to be dead. METHODS: As part of a statewide survey of needs of AIDS patients, samples totalling 275 cases listed as not known dead were drawn from the New Jersey AIDS Registry on 3 occasions. Suffici
Epidemiology, costs, and utilization of pediatric AIDS in NYS Medicaid, 1983-1987.: Int Conf AIDS. 1990 Jun 20-23;6(1):298 (abstract no. Th.C.692). Unique Identifier : AIDSLINE ICA6/10069290; Fanning T; Cosler L; Gallagher P; Chiarella J; Andrews R; Turner B; New York State Dept. of Social Services, Albany, New York, USA; OBJECTIVE: To investigate the epidemiology, survival, and costs of pediatric (less than 13 years) AIDS cases in a poor population. METHODS: The Medicaid claims for one and one-half million children in the New York State over a five year period, 10/82-09/87, were screened for AIDS associated diagnoses. For presumptive
Survival following diagnosis of AIDS-related opportunistic infections in San Francisco (SF).: Int Conf AIDS. 1990 Jun 20-23;6(1):298 (abstract no. Th.C.693). Unique Identifier : AIDSLINE ICA6/10069390; Payne SF; Lemp GF; Franks DF; Rutherford GW; AIDS Office, San Francisco Department of Public Health, San; Francisco, California, USA; OBJECTIVE: To determine lengths of survival following diagnosis of specific AIDS-related opportunistic infections (OIs). METHODS: We calculated median survival (Kaplan-Meier) for AIDS patients presenting with OIs in SF from July 1981 to December 31, 1987. RESULTS: Median survival for AIDS patients presenting with Pneu
Survival experience after TB diagnosis in 1452 AIDS cases: implications for the expansion of the AIDS case definition.: Int Conf AIDS. 1990 Jun 20-23;6(1):298 (abstract no. Th.C.694). Unique Identifier : AIDSLINE ICA6/10069490; Laroche E; Stoneburner R; Araneta M; Adler J; The New York City Department of Health, New York, New York, USA; OBJECTIVE: The CDC AIDS case definition only recognizes extrapulmonary TB in HIV infected as being indicative of AIDS. We analyzed the survival of TB cases reported as AIDS to determine if disease site was a significant determinant of survival. METHODS: A match of TB, AIDS, and vital statistics registries for 1980-89
Cumulative risk of morbidity in 65 patients infected with both HIV and cryptococcus neoformans.: Int Conf AIDS. 1990 Jun 20-23;6(1):298 (abstract no. Th.C.695). Unique Identifier : AIDSLINE ICA6/10069590; Clark R; Greer D; Diamondstone L; Hyslop N; Tulane/LSU ACTU, New Orleans, LA, USA; OBJECTIVE: To determine the cumulative risk of morbidity in HIV infected (HIV+) patients diagnosed with a Cryptococcus neoformans (Cn) infection. METHOD: Hospital records of all HIV+ patients found to be infected with Cn either by microbiological or histopathologic evidence were reviewed retrospectively. All patients
The role of zidovudine in increased survival in AIDS patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):299 (abstract no. Th.C.696). Unique Identifier : AIDSLINE ICA6/10069690; Peters BS; Beck EJ; Coleman DG; Moss F; Harris JR; Pinching AJ; Dept of Immunology, St. Mary's Hospital, London, UK; OBJECTIVE: To study the contribution of zidovudine towards the increased survival time of people with AIDS treated at St. Mary s. METHODS: Two year survival of patients with AIDS was recorded by year of diagnosis. Zidovudine was introduced in April 1987. Therefore we analysed the difference in survival between those t
Changing morbidity and mortality patterns in British AIDS patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):299 (abstract no. Th.C.697). Unique Identifier : AIDSLINE ICA6/10069790; Beck EJ; Peters BS; Coleman DG; Harris JR; Pinching AJ; St. Mary's Hospital & Medical School, London W2 1PG, UK; OBJECTIVE: Describe morbidity and mortality trends in AIDS patients treated at St. Mary s Hospital. METHOD: Index diagnosis, subsequent morbidity and cause of death of AIDS patients diagnosed 1982-89 obtained from casenotes. Two-year survival calculated using Logrank Test (SAS). RESULTS: 347 patients, 51% with index d
Completeness of AIDS surveillance, United States.: Int Conf AIDS. 1990 Jun 20-23;6(1):299 (abstract no. Th.C.698). Unique Identifier : AIDSLINE ICA6/10069890; Buehler J; Berkelman R; Stehr-Green J; Leary L; Centers for Disease Control (CDC), Atlanta, Georgia, USA; OBJECTIVE: To assess the completeness of reporting of CDC-defined AIDS and the extent of severe HIV disease not included in surveillance criteria. METHODS: Published and unpublished evaluation of AIDS surveillance were reviewed and previous analyses of national vital statistics extended. RESULTS: Various methods have
Changes in U.S. AIDS incidence trends.: Int Conf AIDS. 1990 Jun 20-23;6(1):299 (abstract no. Th.C.699). Unique Identifier : AIDSLINE ICA6/10069990; Green TA; Karon J; Stehr-Green J; Centers for Disease Control, Atlanta, Georgia, USA; OBJECTIVE: To describe recent changes in trends in U.S. AIDS incidence and to determine which behavioral, demographic, and geographic subgroups account for observed changes. METHODS: Reported monthly AIDS cases were adjusted for reporting delays and smoothed using robust locally weighted regression (lowess). Reporting
National surveillance for pediatric AIDS in United States.: Int Conf AIDS. 1990 Jun 20-23;6(1):300 (abstract no. Th.C.700). Unique Identifier : AIDSLINE ICA6/10070090; Caldwell B; Fleming PL; Oxtoby MJ; Centers for Disease Control (CDC), Atlanta, Georgia, USA; OBJECTIVES: To describe the epidemiology of AIDS in children less than 13 years old. METHODS: AIDS cases reported to CDC prior to January 1, 1990 were analyzed. RESULTS: Of the 1995 children under 13 reported with AIDS, 81% of cases were perinatally acquired (PA), 5% were in hemophiliacs, 11% were transfusion associat
AIDS surveillance among American Indians and Alaskan Natives.: Int Conf AIDS. 1990 Jun 20-23;6(1):300 (abstract no. Th.C.701). Unique Identifier : AIDSLINE ICA6/10070190; Metler R; Stehr-Green J; Centers for Disease Control (CDC), Atlanta, Georgia, USA; OBJECTIVE: To examine and compare demographic characteristics among American Indians/Alaskan Natives (AI/AN) and other racial/ethnic groups with AIDS. METHODS: We examined U.S. AIDS cases reported to CDC through 12/31/89 by racial/ethnic group. RESULTS: There were 157 AIDS cases reported among AI/AN through 12/31/89 o
AIDS among homosexual/bisexual intravenous drug users in the United States.: Int Conf AIDS. 1990 Jun 20-23;6(1):300 (abstract no. Th.C.702). Unique Identifier : AIDSLINE ICA6/10070290; Nwanyanwu O; Stehr-Green J; Berkelman R; Centers for Disease Control, Atlanta, Georgia, USA; OBJECTIVE: To determine whether male homosexual/bisexual intravenous drug users with AIDS (H/B-IVDUs) resemble male homosexual/bisexuals with AIDS (H/Bs) or male heterosexual intravenous drug users with AIDS (IVDUs) or are unique in their disease patterns. METHODS: We examined reports of adult H/B-IVDUs, H/Bs, and IVD
Epidemiology of AIDS and HIV among California women.: Int Conf AIDS. 1990 Jun 20-23;6(1):300 (abstract no. Th.C.703). Unique Identifier : AIDSLINE ICA6/10070390; Capell FJ; Vugia DJ; Wilson MJ; Mordaunt V; California Department of Health Services, Sacramento, California,; USA; OBJECTIVE: To summarize data on AIDS and HIV among California (CA) women, with regard to recent trends and in comparison to the rest of the US. METHODS: Female intravenous drug use (IVDU) and heterosexual contact (HC) AIDS cases reported in CA through October 1989 are analyzed and compared with female cases from the r
Increasing AIDS case reporting delay in Los Angeles County, 1984 1989.: Int Conf AIDS. 1990 Jun 20-23;6(1):301 (abstract no. Th.C.704). Unique Identifier : AIDSLINE ICA6/10070490; Lieb L; Nahlen B; Wakamatsu P; Los Angeles County (LAC) Department of Health Services,; California, USA; OBJECTIVE: To describe temporal trends in the timeliness of AIDS case reporting in LAC. METHODS: AIDS cases reported to the LAC surveillance registry between 1/1/84 and 12/31/89 were analyzed by dates of diagnosis and report, patient characteristics, and AIDS-indicator disease. The 135 reporting hospitals were grouped
Classic epidemiological mapping of AIDS among San Francisco drug injectors, 1987-1989.: Int Conf AIDS. 1990 Jun 20-23;6(1):301 (abstract no. Th.C.705). Unique Identifier : AIDSLINE ICA6/10070590; Aldrich MR; Payne SF; Margolis E; Biernacki P; Feldman HW; Youth Environment Study (YES), San Francisco, California, USA; OBJECTIVE: To evaluate mapping of the spread of AIDS among San Francisco drug injectors (DIs) by neighborhood, race/ethnicity, and sexual orientation, 1987-89, to target prevention efforts. METHODS: Reported heterosexual and homosexual/bisexual DI AIDS incidence was computer-mapped by census tract neighborhoods and et
The epidemic of AIDS in intravenous drug users (IVDUs) and their heterosexual partners in the southeastern United States.: Int Conf AIDS. 1990 Jun 20-23;6(1):301 (abstract no. Th.C.706). Unique Identifier : AIDSLINE ICA6/10070690; Berkelman R; Fleming P; Green T; Gwinn M; Stehr-Green J; Curran J; Centers for Disease Control (CDC), Atlanta, Georgia, USA; OBJECTIVE: To examine the trends and characteristics of AIDS cases among female and heterosexual male IVDUs and their sex partners (SP) in the Southeastern United States (SE). METHODS: CDC surveillance data for women and heterosexual men reporting IVDU or sexual contact with an IVDU (S
Decreased incidence of reported AIDS cases, New York City.: Int Conf AIDS. 1990 Jun 20-23;6(1):301 (abstract no. Th.C.707). Unique Identifier : AIDSLINE ICA6/10070790; Thomas PA; Hindin R; Greenberg A; Lopez E; Bernard G; Weisfuse I; New York City (NYC) Department of Health, NY, USA; OBJECTIVE: To evaluate a decreasing incidence of reported NYC AIDS cases. METHODS: Incident cases as defined by CDC are examined by half-year of diagnosis in a continuous hospital-based surveillance having a median reporting lag of 3-4 months. Completeness is assessed by comparison with alternate data sources (death c
Completeness of AIDS case reporting and the spectrum of HIV-related disease among outpatients in New York City.: Int Conf AIDS. 1990 Jun 20-23;6(1):302 (abstract no. Th.C.708). Unique Identifier : AIDSLINE ICA6/10070890; Greenberg AE; Evans R; Bryan E; Lopez E; Thomas P; AIDS Surveillance Unit, NYC Dept of Health, NY, USA; OBJECTIVE: To assess the completeness of AIDS case reporting and the spectrum of HIV-related disease among outpatients in New York City. METHODS: Medical records of AIDS and HIV (non-AIDS) outpatients followed through 1989 at 4 NYC hospital HIV clinics and 2 private physicians offices (PPOs) were reviewed; AIDS cases
The AIDS pattern among Canadian aboriginals.: Int Conf AIDS. 1990 Jun 20-23;6(1):302 (abstract no. Th.C.709). Unique Identifier : AIDSLINE ICA6/10070990; Wortman JA; Division of STD Control, Ministry of Health, Vancouver, B.C.,; Canada; OBJECTIVE: To characterize the pattern of AIDS spread in the Canadian aboriginal population for the purpose of shaping prevention strategies. METHODS: The AIDS data for aboriginals, caucasians and blacks in Canada is examined and compared to the AIDS epidemiology models of pattern
Transition from type 1 to type 2 transmission of HIV in the Americas: how widespread the trend?: Int Conf AIDS. 1990 Jun 20-23;6(1):302 (abstract no. Th.C.710). Unique Identifier : AIDSLINE ICA6/10071090; Gonzalez R; Kimball AM; Zacarias F; Zessler L; Pan American Health Organization, 525 23rd Street N.W.; Washington, D.C. 20037 USA; OBJECTIVE: To review, describe, and analyze regional surveillance information and complementary national information suggesting the trend of increasing cases of AIDS in women (attributed to heterosexual transmission) is being seen in Central America and Brazil . METHODS: Regionally
Features of the intravenous drug users exposure category among AIDS cases. Brazil. 1980-1989.: Int Conf AIDS. 1990 Jun 20-23;6(1):302 (abstract no. Th.C.711). Unique Identifier : AIDSLINE ICA6/10071190; Castilho E; Chequer P; Rodrigues L; Oswaldo Cruz Foundation, Rio de Janeiro, Brazil; OBJECTIVE: To describe clinical and epidemiological differentials between IVDU exposure category individuals and homo/bisexual exposure category individuals among adult male AIDS cases. METHODS: The data are from the Brazilian National AIDS registry. Product-limit survival functions, Mann-Whitney test, and chi-square
Epidemiological approach to pediatric AIDS cases in Brazil, 1985-1989.: Int Conf AIDS. 1990 Jun 20-23;6(1):303 (abstract no. Th.C.712). Unique Identifier : AIDSLINE ICA6/10071290; Bergamaschi D; Rodrigues L; Lima G; National Division of STD/AIDS-MOH, Brasilia-DF, Brazil; OBJECTIVE: To update the analysis of pediatric AIDS cases in Brazil , identifying high-risk groups. METHODS: The analysis was based on all pediatric cases reported to the Ministry of Health from 1980 to 1989 and was carried out by means of cross tabulations and statistical tests. Th
Profile of IVDU in a AIDS reference center. Sao Paulo, Brazil, 1988.: Int Conf AIDS. 1990 Jun 20-23;6(1):303 (abstract no. Th.C.713). Unique Identifier : AIDSLINE ICA6/10071390; Gianna MC; Chequer P; Castilho E; Kalichman A; Pinto V; Rodrigues L; State Health Department, Sao Paulo, Brazil; OBJECTIVE: To determine the profile of the IVDU registered in the Center of Reference and Training in AIDS, Sao Paulo, Brazil . METHODS: Four thousand medical charts of outpatients registered in 1988 were reviewed. From those, 541 were IVDU. Socio-demographic, clinical and epidemiol
Epidemiological characteristics of AIDS in women in Rio de Janeiro, Brazil.: Int Conf AIDS. 1990 Jun 20-23;6(1):303 (abstract no. Th.C.714). Unique Identifier : AIDSLINE ICA6/10071490; Koifman RJ; Monteiro GT; Rodrigues R; Quinhoes EP; Noronha CP; Department of Epidemiology, Public Health Services, Municipality; of Rio de Janeiro, Brazil; OBJECTIVE: To determine the epidemiological changing patterns among female AIDS cases in Rio de Janeiro. METHODS: All known female AIDS cases in the city of Rio de Janeiro reported during 1984-89 (151 cases, cumulative incidence of .04/100,000 women) have been studied by hospital interviews. This paper presents some e
Distribution and trends of AIDS cases by socioeconomic strata in Mexico.: Int Conf AIDS. 1990 Jun 20-23;6(1):303 (abstract no. Th.C.715). Unique Identifier : AIDSLINE ICA6/10071590; Bravo E; Magis C; Salcedo RA; Garcia ML; Lezana MA; Sepulveda J; General Directorate of Epidemiology, Ministry of Health, Mexico; OBJECTIVE: To analyze distribution and trends of AIDS cases in the different socioeconomic strata in Mexico . METHODS: 2195 cases older than 12 years old notified to the National AIDS Registry were analyzed. Occupation rates were estimated from the National Health Serosurvey (1986).
Clinical and epidemiological features of pediatric AIDS cases in Mexico.: Int Conf AIDS. 1990 Jun 20-23;6(1):304 (abstract no. Th.C.716). Unique Identifier : AIDSLINE ICA6/10071690; Garcia ML; Salcedo A; Bravo E; Martinez J; Mora JL; Valdespino JL; Sepulveda J; General Directorate of Epidemiology, Ministry of Health, Mexico; OBJECTIVE: To analyze the clinical and epidemiological features of pediatric AIDS cases in Mexico . METHODS: Pediatric registries of AIDS National Registry were analyzed. RESULTS: Pediatric cases represent 3.8% (134/3512) of total AIDS cases. Transmission categories are as follows:
Development of HIV/AIDS epidemic in the country ranking 4th in number of cases in the Americas.: Int Conf AIDS. 1990 Jun 20-23;6(1):304 (abstract no. Th.C.717). Unique Identifier : AIDSLINE ICA6/10071790; Valdespino JL; Garcia L; Mora JL; Magis C; Salcedo A; Bravo E; Sepulveda J; General Directorate of Epidemiology, Ministry of Health, Mexico; OBJECTIVES: To analyze the development of the HIV/AIDS epidemic in Mexico which holds the 4th place in number of cases in the Americas. METHODS: Data of the AIDS National Registry were analyzed. Estimates of infected population and projections of cases foreseen for the coming four
Update on the epidemiology of AIDS in Trinidad.: Int Conf AIDS. 1990 Jun 20-23;6(1):304 (abstract no. Th.C.718). Unique Identifier : AIDSLINE ICA6/10071890; Cleghorn F; Battoo K; Diaz C; Balbosa S; Jack N; Blattner W; Bartholomew C; The University of the West Indies/CAREC, Port of Spain, Trinidad; OBJECTIVES: To describe the epidemiology of AIDS in Trinidad . METHODS: Surveillance for cases of AIDS was conducted throughout the country and demographic and interview data collected. RESULTS: From 1983 to December 31, 1989, 551 ca
AIDS in Cote d'Ivoire: progression of the epidemic in West Africa.: Int Conf AIDS. 1990 Jun 20-23;6(1):304 (abstract no. Th.C.719). Unique Identifier : AIDSLINE ICA6/10071990; Soro B; Moreau J; Gershy-Damet G; Odehouri K; Lavreys L; Lafontaine MF; Porter A; De Cock KM; Heyward WL; Comite National de Lutte Contre le SIDA, Abidjan, Cote d'Ivoire; OBJECTIVES: To provide descriptive characteristics of AIDS, and to calculate minimum cumulative incidence of AIDS in Cote d Ivoire . METHODS: Case records of major hospitals and reference laboratories for AIDS were reviewed. AIDS was diagnosed if a patient was HIV-positive, and
Impact of the 1987 revision of the CDC/WHO case definition on the surveillance of AIDS in Europe.: Int Conf AIDS. 1990 Jun 20-23;6(1):305 (abstract no. Th.C.720). Unique Identifier : AIDSLINE ICA6/10072090; Ancelle-Park R; Couturier E; Downs AM; Brunet JB; WHO Collaborating Centre on AIDS, Paris, France; OBJECTIVE: To assess the apparent impact of the 1987 revision of the CDC/WHO case definition on the surveillance of AIDS in Europe. METHODS: Analysis was carried out on data reported by December 1988 by 23 European countries. Information was recorded on 5 of 12 newly included definitively diagnosed indicator diseases,
Impact of the 1987 revised AIDS case definition on the Danish AIDS epidemic. A follow-up.: Int Conf AIDS. 1990 Jun 20-23;6(1):305 (abstract no. Th.C.721). Unique Identifier : AIDSLINE ICA6/10072190; Smith E; Mathiesen L; Skinh:oj P; Seefeldt T; Isager H; Dept. of Epid., State Serum Institute, Copenhagen, Denmark; OBJECTIVE: To analyze the epidemiological, clinical and laboratory data of the notified Danish AIDS patients meeting only the 1987 AIDS case revision. METHODS: All notified Danish AIDS cases were reevaluated in order to find those meeting only the 1987 AIDS case definition (ACD). A retrospective follow-up was done on
The epidemiology of HIV and AIDS in Scotland.: Int Conf AIDS. 1990 Jun 20-23;6(1):305 (abstract no. Th.C.722). Unique Identifier : AIDSLINE ICA6/10072290; Goldberg D; Emslie J; Green S; Smyth W; Reid D; Communicable Diseases (Scotland) Unit, Ruchill Hospital, Glasgow,; UK; To the end of 1989, a total of 132 cases of AIDS had been reported to the Communicable Diseases (Scotland) Unit, the majority of which were homosexual/bisexual (70 (53%)). By contrast 1729 HIV antibody positive cases had been reported, 910 (52.6%) of which were heterosexual injecting drug users (IDUs) and only 280 (16
AIDS and HIV infection in Australia: a fourth pattern?: Int Conf AIDS. 1990 Jun 20-23;6(1):305 (abstract no. Th.C.723). Unique Identifier : AIDSLINE ICA6/10072390; Kaldor J; Crofts N; Swanson C; McDonald A; Cooper D; National Centre in HIV Epidemiology and Clinical Research,; Sydney, Australia; OBJECTIVE: To monitor the incidence of AIDS and the prevalence of diagnosed HIV infection in Australia . METHODS: National surveillance for HIV infection and AIDS in Australia is carried out by a central epidemiological unit in collaboration with State and Territory Health Author
Distribution of opportunistic infections in AIDS cases by country or region of birth, United States, 1981-1989.: Int Conf AIDS. 1990 Jun 20-23;6(1):306 (abstract no. Th.C.724). Unique Identifier : AIDSLINE ICA6/10072490; Bush TJ; Castro KG; Kreiss JK; Curran JW; Centers for Disease Control, Atlanta, Georgia, USA; OBJECTIVE: Identify differences in the distribution of opportunistic diseases in United States (US) AIDS cases born in developing countries. METHODS: AIDS cases reported to CDC through December, 1989 were stratified by transmission category and analyzed for frequency of opportunistic d
Reported AIDS patients with tuberculosis in the United States.: Int Conf AIDS. 1990 Jun 20-23;6(1):306 (abstract no. Th.C.725). Unique Identifier : AIDSLINE ICA6/10072590; Cauthen GM; Bloch AB; Snider DE; Centers for Disease Control, Atlanta, Georgia, USA; OBJECTIVE: Determine the number of reported AIDS patients with tuberculosis (TB) in the United States . METHODS: AIDS and TB registers through 1988 were matched in 49 States, 3 large California cities (San Francisco, Los Angeles, and San Diego), Puer
HIV seroprevalence in patients attending tuberculosis clinics in the United States, 1988-90.: Int Conf AIDS. 1990 Jun 20-23;6(1):306 (abstract no. Th.C.726). Unique Identifier : AIDSLINE ICA6/10072690; Hnath R; McCray E; Onorato IM; Centers for Disease Control, Atlanta, Georgia, USA; OBJECTIVE: To evaluate the seroprevalence of HIV among patients attending tuberculosis (TB) clinics in the United States . METHODS: Blinded serosurveys are being conducted among patients attending TB clinics in 33 metropolitan areas (MAs). Sera from consecutive TB patients are tested fo8
Association between mycobacterial cultures and HIV infection in a large municipal hospital.: Int Conf AIDS. 1990 Jun 20-23;6(1):306 (abstract no. Th.C.727). Unique Identifier : AIDSLINE ICA6/10072790; Castro KG; Metchock BG; McGowan JE Jr; Thompson SE; Curran JW; Centers for Disease Control, Atlanta, Georgia, USA; OBJECTIVE: Determine the prevalence of HIV-associated mycobacterial infections (MI) at GMH, which serves the indigent population of Atlanta. METHODS: Positive mycobacterial cultures from GMH, Jan-Nov 1989 were analyzed by patient s gender, HIV status, organism, specimen source, and compared with 1982. RESULTS: MI occu8
HIV seroprevalence in patients attending New York City Department of Health (NYCDOH) tuberculosis (TB) clinics.: Int Conf AIDS. 1990 Jun 20-23;6(1):307 (abstract no. Th.C.728). Unique Identifier : AIDSLINE ICA6/10072890; Greenberg B; Weisfuse I; Back S; Tiwari I; Gainey S; Adler J; New York City Department of Health, NY, USA; OBJECTIVE: To determine the seroprevalence of HIV-1 infection in NYCDOH TB clinic patients. METHODS: A blinded serosurvey has been conducted since January, 1989 in patients who have bloods drawn for liver function tests. Serum specimens are tested by ELISA with confirmatory Western Blot. Demographic information includ8
High rates of HIV among municipal tuberculosis (TB) clinic patients with inactive as well as active TB.: Int Conf AIDS. 1990 Jun 20-23;6(1):307 (abstract no. Th.C.729). Unique Identifier : AIDSLINE ICA6/10072990; Barry MA; Bernardo J; Murray C; Coppola D; Recla L; Werner B; Boston Dept. of Health & Hospitals, Boston, MA, USA; OBJECTIVE: To determine HIV seroprevalence rates in persons with TB infection with or without disease attending a municipal TB clinic. METHODS: Unlinked HIV testing was performed (by EIA & Western blot) on specimens from persons with confirmed or suspected TB attending a municipal TB Clinic in Boston from 5/88-11/8
Tuberculosis in HIV infected patients from 1985 to 1989 at the National AIDS Referral Center - HUGG - Rio de Janeiro, Brazil.: Int Conf AIDS. 1990 Jun 20-23;6(1):307 (abstract no. Th.C.730). Unique Identifier : AIDSLINE ICA6/10073090; Morais-de-sa CA; Sion FS; Quinhoes EP; Ismael C; Eyer-Silva WA; Signorini DJ; Cunha-Pinto JF; Motta-Ferreira LE; National AIDS Referral Center, Gaffree & Guinle University; Hospital University of Rio de Janeiro (UNI-RIO), Rio de Janeiro,; Brazil; OBJECTIVE: To study trends of Tuberculosis (TB) infection in HIV infected patients in Rio de Janeiro, Brazil . METHODS: We studied HIV infected pts. from 1985 to 1989 at the National AIDS Referral Center, Gaffree & Guinle University Hospital, University of Rio de Janeiro, presenting
AIDS and tuberculosis in the State of Rio de Janeiro, Brazil.: Int Conf AIDS. 1990 Jun 20-23;6(1):307 (abstract no. Th.C.731). Unique Identifier : AIDSLINE ICA6/10073190; Sanches K; Almeida E; Pinto M; Sole-Cava A; Pan American Health Organization, Rio de Janeiro, Brazil; OBJECTIVE: The purpose of this work was to undertake an in-depth analysis of the relationship between tuberculosis (TB) and AIDS, according to risk group, in Rio de Janeiro. METHODS: We investigated all subjects who died of AIDS until Dec., 1989, as reported in the files of the Health Secretary of State. Only the case
HIV infection and tuberculosis: tuberculosis trends in Abidjan, Cote d'Ivoire, 1985-1989.: Int Conf AIDS. 1990 Jun 20-23;6(1):308 (abstract no. Th.C.732). Unique Identifier : AIDSLINE ICA6/10073290; Yesso G; Bretton R; Bretton G; Coulibaly IM; Coulibaly D; Barrere B; Gnaore E; De Cock KM; Projet RETRO-CI, Abidjan, Cote d'Ivoire; OBJECTIVES: To determine the effect of HIV infection on trends in tuberculosis (TB) incidence and natural history in Abidjan between 1985 (when AIDS was first recognized) and 1989. METHODS: Records of all ambulatory patients treated for TB in Abidjan s two TB Treatment Centers from 1985-1989 were examined. From mid-19
Tuberculosis and HIV infection: a longitudinal study in West Africa: Burkina Faso.: Int Conf AIDS. 1990 Jun 20-23;6(1):308 (abstract no. Th.C.733). Unique Identifier : AIDSLINE ICA6/10073390; Malkin JE; Prazuck T; Simonnet F; Tiendrebeogo H; Fisch A; Ayeroue J; Vincent-Ballereau F; G.E.E.P.: Villeneuve-Saint-Georges, Burkina Faso; OBJECTIVES: 1) To determine the prevalence of HIV infection in a TB population in a West African area. 2) To evaluate the predictive value of symptoms encountered in that particular population. 3) To assess clinical and bacteriological evolution of patients under anti-TB treatment, according to their serological statu
Importance of cerebral toxoplasmosis as an AIDS presenting form in a South-European area.: Int Conf AIDS. 1990 Jun 20-23;6(1):308 (abstract no. Th.C.734). Unique Identifier : AIDSLINE ICA6/10073490; Casabona J; Sanchez E; Graus F; Campillo M; Albos J; Segura A; AIDS Program, Generalitat de Catalunya, Barcelona, Spain; OBJECTIVES: 1- To describe the demographic and epidemiologic characteristics of AIDS patients presenting with an indicative neurologic disorder (IND); 2- to evaluate a possible temporal trend of such a presenting form; and 3- to evaluate its possible influence on the patients survival. METHODS: Data from all AIDS pat
Using international classification of diseases-9th revision (ICD-9) coded hospital discharge data to augment AIDS surveillance.: Int Conf AIDS. 1990 Jun 20-23;6(1):308 (abstract no. Th.C.735). Unique Identifier : AIDSLINE ICA6/10073590; O'Keith G; Froelicher E; Garza A; Lieb L; Eastman C; Williams A; Los Angeles County (LAC) Department of Health Services, AIDS; Epidemiology Program, Los Angeles, California, USA; OBJECTIVE: To evaluate the use of ICD-9 coded hospital discharge data to identify previously unreported AIDS cases in LAC. METHODS: Lists of patients with AIDS-indicative ICD-9 coded discharge diagnoses (042, 043, 044, 279.10, 279.19, 279.30, 136.3, 130.0, 117.5, 321.0, 078.5 and 484.1) were obtained from five hospita
AIDS cases diagnosed as outpatients.: Int Conf AIDS. 1990 Jun 20-23;6(1):309 (abstract no. Th.C.736). Unique Identifier : AIDSLINE ICA6/10073690; Modesitt S; Espenlaub C; Klockner R; Fleming D; Oregon Health Division, Portland, Oregon, USA; OBJECTIVE: To determine whether the characteristics of AIDS cases diagnosed as outpatients differ from those diagnosed as in-patients. METHODS: Physicians reporting AIDS cases in Oregon are asked to indicate on the case report form whether the diagnosis of AIDS was made in the inpatient (IP) or outpatient (OP) setting
Spectrum of HIV-related diseases and conditions among outpatients.: Int Conf AIDS. 1990 Jun 20-23;6(1):309 (abstract no. Th.C.737). Unique Identifier : AIDSLINE ICA6/10073790; Buskin S; Hopkins S; Chamberland M; Seattle/King County Department of Public Health, Seattle, WA, USA; OBJECTIVES: (1) To enumerate persons with HIV infection at different types of outpatient sites in Seattle. (2) To characterize and classify infections, conditions and medical service usage in this population. (3) To examine the use of CD4 counts in treatment and prophylaxis decisions made at these sites. METHODS: As p
Modeling of STDs and HIV: The value of STD surveillance and control in AIDS control programs.: Int Conf AIDS. 1990 Jun 20-23;6(1):309 (abstract no. Th.C.738). Unique Identifier : AIDSLINE ICA6/10073890; Sokal D; Auvert B; AIDSTECH/FHI, North Carolina, USA; OBJECTIVE: To examine the relationship between STD surveillance and control, and AIDS control programs. METHODS: A Monte Carlo simulation model is used to analyze the dynamics of HIV transmission given various levels of STDs and STD control programs. Initial model conditions are studied to achieve stable STD prevalenc
The WHO clinical case-definition of AIDS (WCCDA) in patients with active pulmonary tuberculosis (APT): a prospective study.: Int Conf AIDS. 1990 Jun 20-23;6(1):309 (abstract no. Th.C.739). Unique Identifier : AIDSLINE ICA6/10073990; Werneck E; Kritski AL; Cury D; Ferraz CM; Hollanda T; Galvao-Castro B; Instituto de Tisiologia e Pneumologia-UFRJ, Brazil; OBJECTIVE: To test the WCCDA in patients with APT. METHODS: From Feb. 1987 to Dec. 1989 we performed a physical examination and a standardized questionnaire which covered all parts of the WCCDA was applied to 567 adult inpatients with APT at Santa Maria and Ari Parreira State Hospitals who agreed to be tested for HIV
A clinical case definition for HIV infection among Ugandan patients with Kaposi's sarcoma (KS).: Int Conf AIDS. 1990 Jun 20-23;6(1):310 (abstract no. Th.C.740). Unique Identifier : AIDSLINE ICA6/10074090; Desmond-Hellmann SD; Mbidde EK; Kizito A; Hellmann NS; University of California, San Francisco, California, USA; OBJECTIVE: HIV testing is expensive and not widely available in rural Africa. Aggressive KS is an easily recognized manifestation of HIV infection in African patients. We evaluated the sensitivity and specificity of a case definition for disseminated (epidemic) KS in predicting seropositivity. METHODS: All patients pr
Retrospective review of non-AIDS reports in Los Angeles County based on the revised 1987 AIDS case definition.: Int Conf AIDS. 1990 Jun 20-23;6(1):310 (abstract no. Th.C.741). Unique Identifier : AIDSLINE ICA6/10074190; Nahlen B; Lieb L; Kunz B; Centers for Disease Control (CDC), Atlanta, Georgia, USA; OBJECTIVE: To describe non-AIDS cases reported to LAC and to assess the impact of the 1987 revised case definition (87CD) on reclassification of non-AIDS cases. METHODS: Reports of suspected AIDS cases which do not meet the case definition applicable at the time of the initial investigation are retained and periodical
Spectrum of HIV infection in children: results of active surveillance in 6 geographic areas in USA.: Int Conf AIDS. 1990 Jun 20-23;6(1):310 (abstract no. Th.C.742). Unique Identifier : AIDSLINE ICA6/10074290; Oxtoby M; Mascola L; Cooper B; Hindin R; Maldonado Y; Parrott R; Moye J; Centers for Disease Control, Atlanta, GA, USA; OBJECTIVES: To describe clinically recognized pediatric HIV infections. METHODS: In 1/89 active surveillance for living children less than 13 yrs infected with HIV or born to infected mothers was established in 6 areas which report 40% of pediatric AIDS cases in the U.S. Demographic, clinical and social service data w
Mortality due to HIV infection in adolescents and young adults.: Int Conf AIDS. 1990 Jun 20-23;6(1):310 (abstract no. Th.C.743). Unique Identifier : AIDSLINE ICA6/10074390; Kilbourne BW; Chu SY; Oxtoby MJ; Rogers MF; Centers for Disease Control, Atlanta, Georgia, USA; OBJECTIVE: To assess the impact of HIV infection on mortality in adolescents and young adults in the United States . METHODS: Using national vital statistics data for 1987, we compared deaths for which the underlying cause was HIV infection with other leading causes of death in 10-24 ye
Impact of human immunodeficiency virus epidemic on mortality among women 15 to 44 years of age, United States.: Int Conf AIDS. 1990 Jun 20-23;6(1):311 (abstract no. Th.C.744). Unique Identifier : AIDSLINE ICA6/10074490; Chu S; Buehler J; Berkelman R; Centers for Disease Control, Atlanta, Georgia, USA; OBJECTIVE: To assess the impact of HIV infection on mortality in women of reproductive age in the United States . METHODS: We used final (1985-87) and provisional (1988) data from national vital statistics to describe HIV-related deaths among women aged 15-44 years. RESULTS: While other
Impact of the HIV epidemic on the mortality of children in California.: Int Conf AIDS. 1990 Jun 20-23;6(1):311 (abstract no. Th.C.745). Unique Identifier : AIDSLINE ICA6/10074590; Duliege AM; Wang E; Singleton J; Maldonado Y; Stanford University Medical Center, California, USA; OBJECTIVE: To assess the impact of AIDS and HIV infection relative to other leading causes of death in children in California from 1979-87. METHODS: The leading causes of death for children less than 15 years of age were obtained from vital statistics data for the state of California. Among them, bacterial, viral or o
Mortality among homosexual men in New York City (NYC), 1978-88.: Int Conf AIDS. 1990 Jun 20-23;6(1):311 (abstract no. Th.C.746). Unique Identifier : AIDSLINE ICA6/10074690; Koblin B; Morrison J; Taylor P; Stoneburner R; Stevens C; The New York Blood Center, New York, New York, USA; OBJECTIVE: To examine all-cause and cause-specific mortality rates (MRs) from 1978-88 among a cohort of homosexual men in NYC. METHODS: Subjects were 8925 homosexual men; 8833 participated in studies of hepatitis B from 1978-83 of whom 758 were recruited into a prospective study of AIDS in 1984; 92 were recruited into
The impact of AIDS on patterns of premature death in Canada.: Int Conf AIDS. 1990 Jun 20-23;6(1):311 (abstract no. Th.C.747). Unique Identifier : AIDSLINE ICA6/10074790; Wells G; Rylett D; Semenciw R; Nault P; Laboratory Centre for Disease Control, Ottawa, Ontario, Canada; OBJECTIVE: To assess the impact of AIDS on premature mortality and risk of dying in Canada during the 1980s and evaluate future trends. METHODS: For adults aged 15-64, Potential Years of Life Lost (PYLL) and mortality rates were calculated based on data from Statistics Canada and t
The effect of HIV infection on infant and early childhood mortality in rural Rakai District, Uganda: preliminary results.: Int Conf AIDS. 1990 Jun 20-23;6(1):312 (abstract no. Th.C.748). Unique Identifier : AIDSLINE ICA6/10074890; Konde-Lule JK; Serwadda D; Musgrave S; Wawer MJ; Musagara M; Sewankambo N; Makerere University, Kampala, Uganda; OBJECTIVE: To provide a preliminary assessment of the impact of HIV infection on childhood mortality in rural Rakai District, by comparing mortality rates of children born to HIV positive mothers to those of children born to HIV negative mothers. METHODS: In a community based study carried out in Rakai District, indiv
Prevalence and impact of AIDS among hospitalized internal medicine patients of a general hospital in Kinshasa, Zaire: clinical surveillance data.: Int Conf AIDS. 1990 Jun 20-23;6(1):312 (abstract no. Th.C.749). Unique Identifier : AIDSLINE ICA6/10074990; Kapita B; Nyst M; Liambi L; Behets F; Perriens J; Mama Yemo Hospital, Kinshasa, Zaire; METHODS: Between Feb 1 and Oct 31, 1989 all consecutive admissions to the 209 bed internal medicine dept. of Mama Yemo Hospital were evaluated with a surveillance card containing demographic and risk factor information, entries corresponding to the modified WHO defined clinical case definition of AIDS, used to diagnos
Incidence and mortality from HIV infection in workers and their spouses at 2 large Kinshasa, Zaire businesses.: Int Conf AIDS. 1990 Jun 20-23;6(1):312 (abstract no. Th.C.750). Unique Identifier : AIDSLINE ICA6/10075090; Kaseka N; Batter V; Ndilu M; Kamenga M; Safi E; Kambale R; Ryder R; Projet SIDA, Kinshasa, Zaire; OBJECTIVES: To calculate the yearly HIV incidence, prevalence and mortality in 5766 employees of 2 large businesses and their 4917 spouses. METHODS: Between 1987 and 1989 all employees at 2 businesses and their spouses have undergone 3 annual physical examinations and HIV serology testing. A questionnaire to identify
AIDS as an emerging cause of premature death in Italy.: Int Conf AIDS. 1990 Jun 20-23;6(1):312 (abstract no. Th.C.751). Unique Identifier : AIDSLINE ICA6/10075190; Conti S; Farchi G; Greco D; Istituto Superiore di Sanita', Roma, Italy; OBJECTIVE: To analyze the impact on premature mortality of AIDS in Italy both in the present time and in the near future. METHODS: The demographic indicators referred to as the Years of Potential Life Lost before 65 years were used to evaluate the impact of a mortality cause in the
AIDS incidence and cause specific mortality among intravenous drug users in Rome, Italy.: Int Conf AIDS. 1990 Jun 20-23;6(1):313 (abstract no. Th.C.752). Unique Identifier : AIDSLINE ICA6/10075290; Davoli M; Rapiti E; Forastiere F; Fiume A; Arca M; Perucci CA; Regional Epidemiology Unit, Rome, Italy; OBJECTIVE: To examine AIDS incidence, overall and cause specific mortality rates among intravenous drug users in Italy . METHODS: A cohort of 4202 drug users attending (period 1980-88), at least once, three drug treatment centers in Rome followed-up until 12/31/1988; - AIDS incidence
Undiagnosed HIV-positive deaths.: Int Conf AIDS. 1990 Jun 20-23;6(1):313 (abstract no. Th.C.753). Unique Identifier : AIDSLINE ICA6/10075390; McCormick A; Office of Population Censuses and Surveys, London, WC2B 6JP, UK; OBJECTIVE: Standardised mortality ratios for ninety-five possibly HIV-related causes increased for never-married men aged 15-54 years from 100 in 1984 to 119 in 1988. HIV infection was stated as the cause for only 56% of excess deaths. The study aimed to establish for how many of the remainder HIV infection was undiag
Sentinel surveillance for HIV infection in primary care outpatients in the United States.: Int Conf AIDS. 1990 Jun 20-23;6(1):313 (abstract no. Th.C.754). Unique Identifier : AIDSLINE ICA6/10075490; Petersen LR; Engel R; Herring N; Centers for Disease Control (CDC), Atlanta, Georgia, USA; OBJECTIVE: To monitor nationwide levels and trends of HIV infection in an accessible segment of the general population not selected on the basis of HIV risk factors and not self-selected. METHODS: Anonymous, unlinked (blinded) HIV-seroprevalence survey of leftover specimens submitted by 6,000 primary care physicians t
Significant increases in the annual number of reported HIV-infected patients in U.S. dialysis centers from 1985-1988.: Int Conf AIDS. 1990 Jun 20-23;6(1):313 (abstract no. Th.C.755). Unique Identifier : AIDSLINE ICA6/10075590; Favero MS; Alter MJ; Centers For Disease Control, Atlanta, GA 30333 USA; OBJECTIVE: To determine the annual number and types of U.S. dialysis centers that report dialyzing HIV-infected patients, that routinely test patients for anti-HIV, and the trends in patient numbers. METHODS: Each year a mailed questionnaire was sent to all HCFA licensed dialysis centers to obtain information on the n
The temporal trend of incident HIV seroconversions among young adults in the United States Army: 1985-89.: Int Conf AIDS. 1990 Jun 20-23;6(1):314 (abstract no. Th.C.756). Unique Identifier : AIDSLINE ICA6/10075690; McNeil J; Wann F; Renzullo P; Brundage J; Redfield R; Burke D; Miller R; Walter Reed Army Institute of Research, Washington DC, USA; OBJECTIVE: To describe temporal trends and demographic correlates of incident HIV seroconversion within the United States Army. METHODS: The Department of Defense has provided routine HIB-Ab screening for the uniformed services and for civilian applicants for military service since Novr
Estimated incidence of HIV seroconversion in active duty members of the US Air Force, August 1988-December 1989.: Int Conf AIDS. 1990 Jun 20-23;6(1):314 (abstract no. Th.C.757). Unique Identifier : AIDSLINE ICA6/10075790; Warner R; Wolfe W; Mathis R; Wright E; Epidemiology Division, US Air Force School of Aerospace Medicine,; Brooks AFB, Texas, USA; OBJECTIVE: Total-force HIV screening of active duty US Air Force (USAF) members was begun to identify blood donor deferrals and to determine the incidence of seroconversion in this population. METHODS: Seroconverters were defined as USAF members who tested positive for HIV antibodies by repeated ELISA and Western blotr
Trends of HIV-Ab rates in civilian applicants for military service since 1985.: Int Conf AIDS. 1990 Jun 20-23;6(1):314 (abstract no. Th.C.758). Unique Identifier : AIDSLINE ICA6/10075890; Gardner L; Brundage JF; Goldenbaum MB; Burke DS; Miller RN; Walter Reed Army Institute of Research, Washington DC, USA; OBJECTIVE: To describe the demographic and geographic correlates of HIV prevalence, incidence and incidence acceleration in over 2 million U.S. civilian applicants for military service over the past 4 years. METHODS: Prevalence trends are examined by year of age separately for males and females. Geographic aggregationr
HIV infection among serially tested adult Americans.: Int Conf AIDS. 1990 Jun 20-23;6(1):314 (abstract no. Th.C.759). Unique Identifier : AIDSLINE ICA6/10075990; Cowan DN; Pomerantz RS; Wann ZF; Goldenbaum M; Brundage JF; Miller RN; Burke DS; SRA Technologies, Inc., Alexandria, VA, USA; OBJECTIVES: Assess HIV infection prevalence, incidence, and risk factors in Army Reserve Components (RC) members. METHODS: Members of the RC are required to be tested for HIV infection every 2 years, providing prevalence and incidence information in a large, primarily civilian, geographically dispersed population. Facr
Gonorrhea and syphilis trends during the AIDS epidemic: USA.: Int Conf AIDS. 1990 Jun 20-23;6(1):315 (abstract no. Th.C.760). Unique Identifier : AIDSLINE ICA6/10076090; Moran JS; Peterman TA; Gershman KA; Rolfs RA; Nakashima AK; Zaidi A; Centers for Disease Control, Atlanta, Georgia, USA; OBJECTIVE: Gonorrhea (NG) and syphilis are markers for sexual behaviors that permit transmission of HIV. We analyzed trends in NG and syphilis incidence to learn how they have changed in the US and its subpopulations. METHODS: We reviewed NG and primary and secondary syphilis reported for 1981-88 to CDC. In this abstrr
Risk for AIDS in multiethnic neighborhoods in San Francisco: the AMEN Study.: Int Conf AIDS. 1990 Jun 20-23;6(1):315 (abstract no. Th.C.761). Unique Identifier : AIDSLINE ICA6/10076190; Fullilove M; Wiley J; Fullilove R; Catania J; Golden E; Hulley S; UCSF, Center for AIDS Prevention Studies (CAPS), San Francisco,; CA, USA; OBJECTIVE: To assess the prevalence of HIV and AIDS risk behaviors in a probability sample of single adults in San Francisco, California. METHOD: The Amen Study is a population-based survey of 1781 single adults in three high risk San Francisco neighborhoods. A 45-minute interview was conducted in which respondents wer
Second generation of heterosexual transmission of HIV.: Int Conf AIDS. 1990 Jun 20-23;6(1):315 (abstract no. Th.C.762). Unique Identifier : AIDSLINE ICA6/10076290; Masiero J; Chen R; Armour G; Sone C; Fischl MA; University of Miami AIDS Clinical Research Unit, Miami, Florida,; USA; OBJECTIVES: To evaluate the pattern of heterosexual transmission of HIV among adult AIDS cases reported to the Public Health Department (PHD) in a large urban area. METHODS: An active surveillance program emphasizing accurate, systematic retrieval of demographic information, risk information, and HIV disease patterns r
Prevalence of HIV infection and distribution of risk factors among heterosexuals in Southeast New England.: Int Conf AIDS. 1990 Jun 20-23;6(1):315 (abstract no. Th.C.763). Unique Identifier : AIDSLINE ICA6/10076390; Zierler S; Feingold L; Laufer D; Carpenter C; Mayer K; The New England Behavioral Health Study, Brown University,; Providence, Rhode Island, USA; OBJECTIVE: To describe pattern of occurrence of HIV infection in a heterosexual cohort. METHODS: Interviews and serologies from 653 participants of a population-based prospective study of heterosexual spread of HIV infection provided basis for mathematical modeling of exposure to blood, semen, race, gender, and partner
HIV-1 surveys of premarital blood specimens in a high AIDS incidence state.: Int Conf AIDS. 1990 Jun 20-23;6(1):316 (abstract no. Th.C.764). Unique Identifier : AIDSLINE ICA6/10076490; Altman R; Shahied S; Pizzuti W; Brandon D; Freund C; Dimasi L; New Jersey Department of Health, Trenton, New Jersey, USA; OBJECTIVE: Most statewide premarital HIV-1 testing has been done because of laws in low AIDS incidence states, with a low HIV-1 prevalence being found in these premarital specimens. Therefore, such testing was not considered to have public health value. We have looked at premarital HIV-1 testing in the state with the r
HIV-1 serosurveys of various populations in Newark, N.J.: Int Conf AIDS. 1990 Jun 20-23;6(1):316 (abstract no. Th.C.765). Unique Identifier : AIDSLINE ICA6/10076590; Brandon D; Altman R; Shahied S; Patel R; Pizzuti W; Robeson L; New Jersey State Department of Health, Trenton, NJ, USA; OBJECTIVE: The City of Newark has a very high AIDS case rate; in 1988 the AIDS incidence rate was 133/100,000. In order to determine the prevalence of HIV-1 infection in various populations in this high incidence city, we conducted HIV-1 testing of clients attending various Newark-based clinics and of infants born in r
Using seroprevalence and immunologic data to estimate ambulatory, laboratory and pharmaceutical needs of a largely asymptomatic population.: Int Conf AIDS. 1990 Jun 20-23;6(1):316 (abstract no. Th.C.766). Unique Identifier : AIDSLINE ICA6/10076690; Rautenberg EL; Weisfuse IB; NYC Dept. of Health, AIDS Program Services, New York, NY, USA; OBJECTIVE: To project ambulatory, laboratory and pharmaceutical needs of a largely asymptomatic population by utilizing seroprevalence data combined with information on current immunologic status of seropositive persons. METHODS: A blinded, anonymous serosurvey was conducted in Sexually Transmitted Disease Clinics durr
HIV seroprevalence study of involuntarily hospitalized mentally ill homeless: two time frames in New York City.: Int Conf AIDS. 1990 Jun 20-23;6(1):316 (abstract no. Th.C.767). Unique Identifier : AIDSLINE ICA6/10076790; Empfield M; Cournos F; Weinstock A; Mayers M; Meyer I; Agosin B; Creedmoor Psychiatric Center, Queens, New York, USA; OBJECTIVE: To determine the changing rate of HIV seroprevalence and risk taking behavior among a group of high risk psychiatric patients, i.e., the homeless mentally ill who shun health care services and are involuntarily hospitalized by mental health teams in New York City. METHODS: The study is conducted on the Creer
Predicting risk behavior with the AIDS risk reduction model (ARRM) in a random household probability sample of San Franciscans: the AMEN study.: Int Conf AIDS. 1990 Jun 20-23;6(1):318 (abstract no. Th.D.768). Unique Identifier : AIDSLINE ICA6/10076890; Catania J; Coates T; Kegeles S; Peterson J; Marin B; Fullilove M; University of California San Francisco, Center for AIDS; Prevention Studies (CAPS), San Francisco, California, USA; OBJECTIVE: Data from the AIDS In Multi-Ethnic Neighborhoods survey are used to test Stages 1 & 3 of ARRM (a three stage process model of sexual risk behavior change; Catania, Kegeles, & Coates, 1990). Stage 1 analyses examine predictors of labeling one s sexual behavior in terms of HIV risk; Stage 3 concerns pr
Sexual behaviour in the City of Lisbon - Preliminary Results: Int Conf AIDS. 1990 Jun 20-23;6(1):318 (abstract no. Th.D.769). Unique Identifier : AIDSLINE ICA6/10076990; Amaro F; Teles L; Dantas A; Technical University of Lisbon, Lisbon Portugal; OBJECTIVES: 1- Study sexual behaviour of the population in general to obtain more knowledge, in order to elaborate sexual programmes related to AIDS. 2- To develop a methodology to study sexual behaviour in random samples of the population in general. METHODS: 1- A questionnaire on sexual behaviour was designed upon t
Sexual behavior of a French population and precautions facing AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):318 (abstract no. Th.D.770). Unique Identifier : AIDSLINE ICA6/10077090; Lhomond B; Bouhet B; Denni B; Lagrange H; Zorman M; P.R.O.M.S.T, France; I. The study describes the sexual behavior of the population and focuses on multiple sexual partnership in relation to the diversity of sexual practices and use of condoms. II. The examined population is a representative sample (drawn by quota-sex, age, place of living) of 1511 people, 18 to 59 years old, living in Rh
Sexuality and AIDS in the Netherlands; results from a national survey.: Int Conf AIDS. 1990 Jun 20-23;6(1):319 (abstract no. Th.D.772). Unique Identifier : AIDSLINE ICA6/10077290; Sandfort T; Van Zessen G; De Vroome E; Straver C; Tielman R; University of Utrecht, Utrecht, The Netherlands; OBJECTIVE: To describe the sexual behavior of Dutch citizens in the context of HIV transmission as it relates to: potential risk of transmission, awareness of this risk, knowledge about AIDS, the endorsement of misperceptions about transmission. METHODS: A representative sample of 1000 Dutch citizens between the ages
Sexual behavior and knowledge about AIDS in students.: Int Conf AIDS. 1990 Jun 20-23;6(1):319 (abstract no. Th.D.773). Unique Identifier : AIDSLINE ICA6/10077390; Elsing C; Musial F; Seifert B; Erckenbrecht JF; Strohmeyer G; Department of Medicine, Heinrich-Heine University, Dusseldorf,; FRG; INTRODUCTION: Knowledge about different risk behaviors is an important basis for the success of AIDS information campaigns. For this reason, a 26 item questionnaire was given to 604 university students (44% male and 56% female) to evaluate sexual behavior and knowledge about AIDS. Students were divided into three subg
AIDS knowledge and sexual behavior among University of Puerto Rico students.: Int Conf AIDS. 1990 Jun 20-23;6(1):319 (abstract no. Th.D.774). Unique Identifier : AIDSLINE ICA6/10077490; Cunningham I; Rodriguez Sanchez M; University of Puerto Rico, Rio Piedras Campus, Rio Piedras,; Puerto Rico; OBJECTIVES: To study sexual behavior, drug experience, and knowledge of AIDS among University of Puerto Rico students and the interrelations of these factors. METHODS: A 122 item questionnaire was administered to a representative sample of 3905 students from 10 campuses of the
Adolescent education for sexuality--a strategy for AIDS prevention in developing cultures.: Int Conf AIDS. 1990 Jun 20-23;6(1):319 (abstract no. Th.D.775). Unique Identifier : AIDSLINE ICA6/10077590; Shah B; Thakur V; Bhimani G; Gilada I; Indian Health Organisation, J. J. Hospital, Bombay, India; OBJECTIVE: Our interest has been to identify, cost minimizing and culturally congruent strategies towards AIDS and STD prevention within the relevant economically handicapped ethos of countries like India . METHOD: Effectivity of AIDS and STD prevention, embedded within an education
Belgian adolescents and AIDS. A survey of risk behaviour and prevention.: Int Conf AIDS. 1990 Jun 20-23;6(1):320 (abstract no. Th.D.776). Unique Identifier : AIDSLINE ICA6/10077690; Nieuwinckel S; Knops N; Poppe E; Van Hove E; University of Antwerp - U.I.A., Antwerp, Belgium; OBJECTIVE: Survey of sexual behaviour of Belgi