(Producer) Features the blue collar worker concerned about casual contagion in the workplace. Viewers encounter factory and clerical workers -- men and women who are Black, Asian, Latino, Caucasian, married, divorced, and single.
(Producer) This video helps nurses conquer fear of AIDS and provide skilled, compassionate care to their AIDS patients, in a safe environment. It does so by teaching what AIDS is, how it is transmitted, and how to take appropriate infection control precautions. The program explains how HIV infection progresses and h
Rockville, MD : U.S. Dept. of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse ; Washington, DC : For sale by the Supt. of Docs., U.S. G.P.O., 1988 xi, 112 p. : ill (NIDA research monograph ; 83) Unique Identifier : AIDSLINE CAT/9005393
General Rockville, MD : U.S. Dept. of Health & Human Services, Public Health Service, Centers for Disease Control, [1988] 7 p. : ill., ports (HHS publication ; no. (CDC) HHS-88-8404) Unique Identifier : AIDSLINE CAT/9005534
Dordrecht, The Netherlands ; Boston : Martinus Nijhoff Publishers ; Norwell, MA, U.S.A. : Sold and distributed in the U.S.A. and Canada by Kluwer Academic Publishers, c1989 xliii, 296 p Unique Identifier : AIDSLINE CAT/9005135
London ; Washington : Panos Institute ; Philadelphia, PA : New Society Publishers, 1989 v, 198 p. : ill (Panos dossier) Unique Identifier : AIDSLINE CAT/9005315
Toronto ; Philadelphia : B.C. Decker ; St. Louis, Mo. : Sales and distribution, United States and Puerto Rico, : C.V. Mosby Co., 1989 113 p. : ill Unique Identifier : AIDSLINE CAT/9005343
London : Royal Society, [1989] 149 p. : ill (Philosophical transactions of the Royal Society of London. Series B, Biological sciences, ISSN 0080-4622 ; v. 325 = no. 1226 (5 Sept. 1989)) Unique Identifier : AIDSLINE CAT/9005370
Myrick-Torres JJ; United States International Univ.
The purpose of this study was to determine the relationship between AIDS patients and Cancer patients in regard to the grief process as described by the Kubler-Ross model of stages of loss. Method. The Affective Response to Illness Scale (ARIS) was modified from a validated, unnamed questionnaire. The ARIS asked subje
The cap structure, m7GpppX (where X = any nucleotide), is present at the 5 end of all eukaryotic cellular messenger RNAs (except organellar). Previous studies have demonstrated that during protein synthesis the cap structure is recognized by a approx 24 kD cap binding protein (CBP), termed eukaryotic initiation facto
Luzi G; Pesce AM; De Luca S; Carlesimo M; Aiuti F; Dept. of Allergy and Clinical Immunology, Univ. of Rome La; Sapienza, Viale dell'Universita 37, 00185 Rome, Italy
Vaccines are available for several viral diseases (eg, smallpox, poliomyelitis, measles, and hepatitis B), but many viral infections cannot be prevented by specific vaccines. In addition, vaccines cannot be used extensively in immunocompromised hosts. These problems have led to the introduction of a pro-host approac
The biological synthesis of 5-[125I] iododeoxyuridine-monophosphate and triphosphate by enzymatic phosphorylation of 5-[125I] iododeoxyuridine and their subsequent purifications are described. The specificity and gain in sensitivity achieved with these substrates in enzyme assays is demonstrated. The increased sensiti
American Society of Pediatric Hematology/Oncology. Second Annual Meeting. September 15-17, 1989, Chicago, IL, 26 p., 1989.. Unique Identifier : AIDSLINE ICDB/90662137
Anonymous; No affiliation given
The second annual meeting of the American Society of Pediatric Hematology/Oncology was held September 15-17, 1989, in Chicago, IL. Before the meeting, a workshop was conducted on the use of iv immunoglobulins in pediatric patients with Kawasaki disease, AIDS/ARC, and cytomegalovirus
Jaagsiekte is a contagious cancer affecting the lungs of sheep. Although the etiological agent is Jaagsiekte retrovirus (JSRV), two other retroviruses--viz, South African maedi visna virus (SA OMVV) and a novel Bovine retrovirus (BRV)--have been associated with or implicated in the jaagsiekte disease complex. JSRV was
The purpose of this study was to determine differences, if any, on symptoms encompassing nine dimensions of psychological distress during bereavement, as assessed through the Symptom Check List-90-R, between a sample of parents of adults who died of AIDS and a sample of parents of adults who died of cancer, and to dra
It is established in our laboratory that in terminally differentiated chicken myotubes, where no chromosomal DNA replication takes place, RSV can infect and synthesize RSV-DNA. We have examined the synthesis of RSV mRNA and the particles produced from the late-infected myotubes (LIM) (defined as such, because they wer
The reciprocal chromosome translocation t(8;14), involving the heavy chain locus on chromosome 14 and the c-myc oncogene on chromosome 8 is a characteristic of the B-cell malignancies Burkitt lymphoma, AIDS-associated non-Hodgkin lymphoma (NHL), and acute lymphoblastic leukemia (ALL). Previous molecular analyses of th
In vitro and in vivo studies of the antiretroviral efficacy, pharmacokinetics, and toxicity of phosphonoformate (PFA) were conducted using the feline leukemia virus (FeLV)/cat system as a model for acquired immunodeficiency syndrome (AIDS). FeLV infection of 3201 cells, on FeLV-negative feline lymphoma cell line, was
Zidovudine ( AZT ) is currently the only antiviral drug approved for the treatment of acquired immunodeficiency syndrome (AIDS). In patients, this agent is rapidly eliminated from the body with a terminal half-life of less than 2 hr following oral dosin
c-fms is the gene encoding the receptor for the hematopoietic growth factor M-CSF. It was initially identified as the cellular homologue of v-fms, the retroviral oncogene carried by the Susan McDonough and Hardy-Zuckerman 5 strains of feline sarcoma virus. v-fms is capable of producing fibrosarcomas in vivo and transf
Franciolini B; Censori B; Provinciali L; Del Pesce M; Petrelli E; Ancarani F
A group of patients with HIV infection in various stages of the disease was studied with regard to CSF, neuroradiological and neuropsychological aspects. A considerable number of them showed signs of CNS involvement, as revealed by abnormalities in all the three fields investigated, despite a frequently unremarkable n
Kapadvanjwala M; Sofer SS; Biotechnology Laboratory, New Jersey Institute of Technology,; Newark 07102.
A simple numerical simulation of AIDS patient detoxification by a hypothetical extracorporeal device for the removal of viruses, infected white cells, and syncytia has been designed. The mathematical model accounts for healthy blood white cells attacking and destroying the viruses, while at the same time the viruses a
In this study, we present direct evidence for the binding of the inducible cellular protein, HIVEN86A, to a 12-bp element present in the IL-2R alpha promoter. This element shares significant sequence similarity with the NF-kappa B binding sites present in the HIV-1 and kappa immunoglobulin enhancers. Transient transfe
Sculerati N; Ambrosino MM; Avni-Singer AJ; Horwitz DA; Lawrence RM; Department of Otolaryngology, New York University Medical Center,; New York.
Twelve children with laboratory evidence of human immunodeficiency virus (HIV) infection underwent diagnostic flexible bronchoscopy with washings or bronchoalveolar lavage at Bellevue Hospital Center from October 1987 to April 1989. The patients included 7 boys and 5 girls ranging from age 3.5 months to 10 years 5 mon
Recapping is the most common cause of preventable needlestick injury. Needlestick injury can be prevented by proper handling techniques. Needlestick injury can transmit the hepatitis virus to the victim. Double-gloving protects against fluid contamination but does not add any more protection against needlesticks than
Nakao K; Ohba N; Isashiki M; Isashiki Y; Unoki K; Osame M; Department of Ophthalmology, Kagoshima University Faculty of; Medicine, Japan.
Ophthalmological evaluations were made of the records of a series of 38 patients with HTLV-I-associated myelopathy, a chronic progressive myelopathy caused by human T-lymphotropic virus type I (HTLV-I). Four patients with no contributory family history showed pigmentary degenerative changes of the retina and choroid.
A 70-year-old woman was admitted complaining of gait disturbance and difficulty in urination. Neurological examination showed myelopathy and both serum and CSF anti ATLA antibodies were positive. A diagnosis of HTLV-associated myelopathy (HAM) was made and steroid therapy was initiated. Chest X-ray film on admission s
Klin Med (Mosk). 1989 Nov;67(11):44-7. Unique Identifier : AIDSLINE MED/90173013
Rakhmanova AG; Prigozhina VK; Smirnov AV; Isakov VA; Stavitskii NI
Hepatic status was studied in 7 HIV-infected patients at the stage of generalized lymphadenopathy. Intravital needle biopsy obtained from the livers characterizes the latter as enlarged, showing signs of protein-synthesis dysfunction, morphological evidence of mild cytolysis, cholestasis, moderate mesenchymal-inflamma
Minerva Chir. 1989 Nov 15;44(21):2241-4. Unique Identifier : AIDSLINE MED/90174441
Cavallaro G; Artuso B; Accordino A; Costa F; Bruno T; Jelasi A
The controversies arising in recent years over the possible transmission of viruses including the hepatitis and HTLV III type in blood derivatives that have been more or less purified or screened for specific antibodies are still to be fully resolved. Though some statistical epidemiological studies seem to exclude the
Palomba E; David O; Boltri A; Gabiano C; Tovo PA; Department of Pediatrics, University of Turin, Italy.
Erythrocyte adenosine deaminase (ADA) activity was assessed in 33 children born to human immuno-deficiency virus (HIV)-positive mothers. The enzyme values were significantly increased in infected, symptom-free children compared with a control group of HIV-negative subjects (mean +/- SD: 0.34 +/- 0.01 unit/ml red blood
An infection with Pneumocystis carinii with clinical symptoms of pneumonia is particularly frequent in patients with AIDS. The authors discuss current knowledge on Pneumocystis carinii pneumonia, including clinical course, possibility of diagnosis, and chemotherapy in patients with AIDS.
Hingson R; Strunin L; Craven DE; Mofenson L; Mangione T; Berlin B; Amaro H; Lamb GA; Social and Behavioral Sciences Section, Boston University School; of Public Health, Massachusetts 02118.
In October 1987, 1,323 Massachusetts residents were randomly interviewed by telephone to explore their exposure to AIDS educational efforts, levels of knowledge about AIDS, and whether that knowledge modified their behavior. Gay/bisexual males, iv drug users and heterosexual respondents were compared as were blacks, H
Spiess BD; Narbone RF; McCarthy RJ; Tuman KJ; Rettke S; Ivankovich AD; Department of Anesthesia, Rush Medical College, Chicago, IL.
Liver transplantation procedures are being performed at an increasing number of hospitals throughout the United States . These procedures are challenging because of hemodynamic, metabolic, renal, and coagulation dysfunctions and may require prolonged periods of time for completion. Anes
Frater RW; Sisto D; Condit D; Department of Cardiothoracic Surgery, Albert Einstein College of; Medicine, Bronx, NY.
Intravenous drug addicts have always been at risk for acquiring infective endocarditis. In the United States in recent years, as many as 50% of addicts have become infected also with the human immunodeficiency virus (HIV). Since testing became available in late 1984, we have knowingly
Community Health Stud. 1989;13(4):410-22. Unique Identifier : AIDSLINE MED/90183287
Tahmindjis P
This article examines the laws in Australia which relate to AIDS, and considers whether they help or hinder the community health concern of containment of fatal diseases. The laws relating to notifications, blood and organ donations, discrimination and other provisions are canva
Hosp J. 1989;5(3-4):135-51. Unique Identifier : AIDSLINE MED/90185598
Carr EW
Hospice programs which, through experience, have become aware of the psychosocial issues of patients with AIDS, need to share their observations. Patients react to the physical realities of the disease while experiencing the stigma and fear which society imposes on AIDS. Hospice support of parents of patients with AID
Int J Addict. 1989 Nov;24(11):1035-51. Unique Identifier : AIDSLINE MED/90186017
Jackson JF; Rotkiewicz LG; Quinones MA; Passannante MR; Division of Narcotic and Drug Abuse Control, New Jersey State; Department of Health, Newark.
The New Jersey State Department of Health developed a program to test the following hypotheses: (1) numerous heroin addicts will respond to free detoxification treatment offered through a coupon program, (2) a substantial number of these patients will continue in treatment beyond the free detoxification attempt, and (
Nagatani T; Kim S; Baba N; Miyamoto H; Minato K; Shimoyama M; Nakajima H
We studied surface markers present in 56 cases of lymphoma of the skin by immunohistochemical staining, using the ABC (avidin-biotin-peroxidase complex) and PAP (peroxidase-antiperoxidase complex) methods. Of these cases, 49 were T-cell lymphoma and 7 were B-cell lymphoma. Ten of the 49 cases of T-cell lymphoma were a
Derouin F; Rabian-Herzog C; Ballet JJ; Laboratoire de Parasitologie Mycologie, Inserm U 108, Hopital; Saint-Louis, Paris, France.
The containment of Toxoplasma gondii infection is largely dependent of T cell mediated immunity. In this study, in vitro lymphocyte responsiveness to T. gondii antigen was examined in 59 HIV1 infected individuals and in 58 HIV non-infected controls. Of the 45 patients with serological evidence of past Toxoplasma infec
Postepy Hig Med Dosw. 1989;43(1):53-60. Unique Identifier : AIDSLINE MED/90192528
Kazimierska E
This paper is a shortly review of antiviral drugs and drugs which help to restore the immune system in patients with AIDS. A significant number of these drugs are being researched for use in AIDS at the different medical centres in Europe and USA.
Ann Med Interne (Paris). 1989;140(8):731-4. Unique Identifier : AIDSLINE MED/90196784
Vidal-Trecan G; Chevallier J; Service d'Epidemiologie, Paris.
The evolution of hospitalization for patients with HIV infections in Parisian public hospitals (Assistance Publique de Paris) can be analyzed from the data base containing discharge diagnoses and from the results of a cross-sectional survey on a given day. At present, the activity associated with HIV infection represe
Telzak EE; Hii J; Polsky B; Kiehn TE; Armstrong D; Department of Medicine, Memorial Sloan-Kettering Cancer Center,; New York, NY 10021.
A case of Nocardia asteroides pneumonia in a patient with the acquired immunodeficiency syndrome who was intolerant of sulfadiazine is described. On cefuroxime, the patient had a complete resolution of his Nocardia pneumonia. Disk-diffusion and broth microdilution antibiotic susceptibility testing (MIC less than or eq
Montgomery AB; Department of Medicine, University of New York, Stony Brook; 11794.
Immunosuppression due to human immunodeficiency virus type 1 (HIV) infection has led to a marked increase in Pneumocystis carinii pneumonia (PCP). Prophylaxis against PCP is standard practice in pediatric cancer patients but is associated with unique problems in HIV-infected patients, including the need for lifelong t
Starke JR; Baylor College of Medicine, Houston, TX 77030.
Tuberculosis (TB) continues to be a major cause of morbidity and mortality throughout the world. One billion people are infected with the tubercle bacillus, and there are 8 million new cases and 3 million deaths annually. Existing methods of preventing TB are effective, but due to economic and societal constraints, ha
McGeachie RE; Nelson MJ; Department of Diagnostic Radiology, University of Minnesota,; Minneapolis.
Magnetic resonance imaging is the modality of choice for the characterization of intracranial inflammation, by defining ependyma, white matter, gray matter, and leptomeningeal involvement. Hemorrhage is well shown, but calcification is difficult to identify. Intravenous Gd-DTPA is useful in the evaluation of B-b barri
Gene. 1989 Dec 28;85(2):461-9. Unique Identifier : AIDSLINE GENBANK/J03776
Patarca R; Singh RP; Durfee T; Freeman G; Blattner FR; Cantor H; Department of Pathology, Harvard Medical School, Boston, MA; 02115.
Analysis of the region 3 to the CD4+ T-cell gene Rpt-1 (encoding regulatory protein T-lymphocyte 1) led to the definition of a silencer element that inhibits heterologous gene expression in certain CD4+ T-cell lines but not in B-cell or non-lymphoid cell lines. Functional silencer activity in vivo was associated with
Immunol Lett. 1989 Oct;22(4):307-11. Unique Identifier : AIDSLINE MED/90185846
Schlesinger M; Bar-Shavit Z; Hadar R; Rabinowitz R; Hubert H. Humphrey Center for Experimental Medicine and Cancer; Research, Hebrew University, Hadassah Medical School, Jerusalem,; Israel.
The CD4 molecule functions as a receptor for the binding and infectivity of the human immunodeficiency virus (HIV). It is of interest, therefore, to develop procedures for its down-regulation. In the present study, the effect of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on the expression of cell surface antigens of the H
Int Ophthalmol. 1989 Dec;13(6):399-402. Unique Identifier : AIDSLINE MED/90186070
Holland GN; UCLA Uveitis Center.
Disseminated toxoplasmosis is a well-known complication of immunodeficiency states, including those induced by malignancies, steroid and cytotoxic drug therapy, and AIDS. In immunodeficient patients, toxoplasmic infections of the eye are less common than toxoplasmic infections of other organs for unknown reasons. When
Int Ophthalmol. 1989 Dec;13(6):407-13. Unique Identifier : AIDSLINE MED/90186072
Dutton GN; Tennent Institute of Ophthalmology, Western Infirmary, Glasgow,; United Kingdom.
The manifestations of congenital toxoplasmosis vary considerably in degree, characteristics and time of onset. Options for prevention of the disease include the appropriate disposal of cat litter and the avoidance of ingestion of both contaminated food and undercooked meat by pregnant women. Immunisation of the domest
Steinman RM; Laboratory of Cellular Physiology and Immunology, Rockefeller; University, New York, N.Y. 10021.
Clinical aspects of dendritic cells have yet to be studied intensively. One obstacle, that of isolating and identifying dendritic cells from human blood and other tissues like skin and tonsil, is being overcome, although the field would be facilitated by dendritic-cell-specific monoclonals or other probes. Many of the
Ann N Y Acad Sci. 1989;569:231-9. Unique Identifier : AIDSLINE MED/90196843
McGowan JJ; Developmental Therapeutics Branch, National Institute of Allergy; and Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892.
Ann N Y Acad Sci. 1989;569:240-74. Unique Identifier : AIDSLINE MED/90196844
Anderson RM; Ng TW; Boily MC; May RM; Parasite Epidemiology Research Group, Imperial College, London; University, England.
A model is developed to describe the spread of HIV within heterosexual communities and the demographic impact of AIDS. The model combines epidemiologic and demographic processes and is designed to mirror the impact of AIDS in sub-Saharan Africa. Refinements on past work in this area include unequal probabilities for t
Ann Cardiol Angeiol (Paris). 1989 Dec 30;38(10):603-10. Unique Identifier : AIDSLINE MED/90197097
Chapelon C; Godeau P; Hopital Pitie-Salpetriere, Service de Medecine Interne,; Paris.
Since first individualized in Atlanta in 1981, the frequency of AIDS is constantly increasing and the risk groups (male homosexuals, heroin addicts, transfused hemophiliacs, Haitians and Africans) are no longer the only ones concerned. The progression of the disease in African heterosexuals foreshadows its probable co
Lenardo MJ; Kuang A; Gifford A; Baltimore D; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
To characterize the NF-kappa B binding factor in molecular terms and to facilitate the cloning of its gene, we have purified this protein from bovine spleen tissue. We have found it is a 42,000-dalton protein that exists in solution as a dimer. We were able to use the purified protein to show that the same polypeptide
Med Law. 1989;8(2):119-23. Unique Identifier : AIDSLINE MED/90173713
Musacchio de Zan A; D'Agnone OA
Current research in Buenos Aires shows that approximately 35 per cent of intravenous users are HIV positive. These patients have behaviour disorders. Usually they are sent from one specialist to another, which increases their anxiety that originated in their suspicion of a serious prognosis. They are listened to when
C R Acad Sci III. 1989;310(3):61-4. Unique Identifier : AIDSLINE MED/90182294
Rayner B; Matsukura M; Morvan F; Cohen JS; Imbach JL; Laboratoire de Chimie bio-organique, U.A. n 488, C.N.R.S.,; Universite de Montpellier-II.
Oligonucleotide analogs consisting exclusively of alpha-anomeric deoxynucleoside units bridged with phosphorothioate linkages have been synthesized and tested in vitro as antiviral agents against human immunodeficiency virus (HIV) in human T cells. Two 28-mers, an homopolymer alpha-S-dC28 and an oligomer alpha-S-anti-
Aust N Z J Ophthalmol. 1989 Nov;17(4):405-8. Unique Identifier : AIDSLINE MED/90166453
Heery S; Hollows F; Department of Opthalmology, Prince of Wales Hospital, Randwick; New South Wales, Australia.
A patient with acquired immune deficiency syndrome (AIDS) with bilateral cytomegaloviral ( CMV ) retinitis who had become neutropaenic from intravenous gancyclovir, was treated with a total of 16 intravitreal 2 mg/0.1 ml doses of gancyclovir in each eye under topi
To KW; Nadel AJ; Department of Ophthalmology, Lenox Hill Hospital, New York, NY; 10021.
Cytomegalovirus ( CMV ) retinitis is a common and one of the most serious ophthalmic manifestations of the acquired immunodeficiency syndrome (AIDS). Early recognition is essential in the proper management of this necrotizing and progressive infection. We discuss
The clinical course of 3 patients treated with the virostatic drug dihydroxypropoxymethylguanine (DHPG) is reported. With maintenance therapy the progression of retinitis was slow, but was not stopped. More rapid progression of retinitis could be observed after cessation of therapy because of DHPG-induced leukopenia.
Adenoviruses are a major cause of respiratory illnesses in military recruits and also are common causes of respiratory and gastrointestinal infections during childhood. Forty-one serotypes of human respiratory and enteric adenoviruses have been identified. Live, oral adenovirus vaccines developed for the military and
Z Gastroenterol. 1989 Dec;27(12):725-30. Unique Identifier : AIDSLINE MED/90177392
Heise W; Mostertz P; Arasteh K; Nehm K; Skorde J; Schneider C; Timm H; Grosse G; Niedobitek F; L'age M; II, Innere Abteilung (Gastroenterologie und Infektiologie),; Auguste-Viktoria-Krankenhaus, Berlin-Schoneberg.
Cytomegalovirus ( CMV ) infection is one of the most important intestinal opportunistic infections in AIDS. In severe cases ulcerations and colitis are the commonest manifestations. 184 HIV positive patients with gastrointestinal symptoms were investigated by endo
Ann Ophthalmol. 1989 Dec;21(12):468-74. Unique Identifier : AIDSLINE MED/90178964
Freeman WR; Henderly DE; Lipson BK; Rao NA; Levine AM; Department of Ophthalmology, University of California, San Diego; School of Medicine, La Jolla 92093.
We reviewed the records of ocular examinations of patients referred or examined for inflammatory retinal disease over a two-year period and found 18 cases in which retinopathy was documented before the diagnosis of acquired immunodeficiency syndrome (AIDS). Seventeen patients were either homosexual men or intravenous
Berthold F; Krueger GR; Tesch H; Hiddemann W; Children's Hospital, University of Cologne, F.R.G.
Clonal gene rearrangements and aneuploidy are commonly recognized as characteristics of malignancy. We challenge this by an observation of a 3 1/2 year old boy with chronic benign lymphadenopathy, connatal splenomegaly and peripheral lymphocytosis. His brother and mother suffered from similar disease without progressi
Gene. 1989 Dec 28;85(2):565-6. Unique Identifier : AIDSLINE MED/90185234
Weber IT; NCI-Frederick Cancer Research Facility, BRI-Basic Research; Program, MD 21701.
All the known retroviral proteases can be accommodated into the structural alignment of the Rous sarcoma virus and human immunodeficiency virus proteases.
This paper reviews the major information on lymphoproliferative diseases developing in primary and acquired immunodeficiencies, in organ allograft recipients, and in different diseases with immune impairment such as rheumatoid arthritis, angioimmunoblastic lymphadenopathy, and Hodgkin s disease (secondary lymphomas).
Kawai S; Nishizawa M; Shinno-Kohno H; Shiroki K; Department of Tumor Virus Research, University of Tokyo.
SR-RSV-D(H), a variant virus with extremely high tropism for mammalian cells, was isolated by passage of the Schmidt-Ruppin strain of Rous sarcoma virus of subgroup D (SR-RSV-D) through hamster cells. This variant virus has acquired an altered envelope glycoprotein, encoded by the env gene, that has high affinity for
Wiersbitzky S; Eberle J; Ladstatter L; Hollinger J; Bruns R; Deinhardt F; Bittner S; Abel E
As to the present knowledge the critical rose rash of infants (exanthema subitum, roseola infantum) means to be an exanthematous infectious disease that, occurring preferably in elder babes and younger infants (1st--3rd year of life), is caused by the newly detected herpesvirus (now the sixth one) pathogenic for man.
Sheep are highly susceptible to BLV infection and can be infected via several different means (routes). In all inoculated animals, specific anti-BLV antibodies can be demonstrated 1 to 3 months post-inoculation (p.i.). Between 10 and 13 months p.i., a moderate but persistent lymphocytosis (PL) may be detected in about
Vet Immunol Immunopathol. 1989 Oct;22(3):265-73. Unique Identifier : AIDSLINE MED/90194692
Maruyama K; Fukushima T; Mochizuki S; Department of Pathology, Chiba Cancer Center Research Institute,; Japan.
Sera of 22 cattle naturally infected with bovine leukemia virus (BLV), of 2 calves vaccinated with BLV, and of 22 patients with human T cell leukemia virus type I (HTLV-I) infection were tested to BLV and HTLV-I by enzyme-linked immunosorbent assay (ELISA) and Western blotting (WB). Sera of 22 healthy cattle and from
Nakao K; Ohba N; Matsumoto M; Department of Ophthalmology, Kagoshima University Faculty of; Medicine, Japan.
A consecutive series of 34 patients with HTLV-I-associated myelopathy (HAM), a neurological disease associated with human T-lymphotropic virus type I (HTLV-I), were studied with reference to endogenous ocular disorders. These patients were examined at the Kagoshima University Hospital between 1986 and 1988. Five of th
Ibrahim SS; Boudinot FD; Department of Pharmaceutics, College of Pharmacy, University of; Georgia, Athens 30602.
The effects of dose on the pharmacokinetics of 2 ,3 -dideoxycytidine (DDC), a potent inhibitor of HIV replication, have been studied in rats. DDC was administered intravenously at doses of 10, 50, 100 and 200 mg kg-1. Plasma and urine drug concentrations were determined by HPLC. Non-compartmental pharmacokinetic param
Ann Ig. 1989 Jan-Apr;1(1-2):125-32. Unique Identifier : AIDSLINE MED/90166410
Ajello O; Cangelosi C; D'Accardo AM; D'Agostino S; Firaux R; Giardina AR; Majolino I; Marciano R; Menozzi M; Patti S; et al
During a period of four consecutive years (1984-1988) more than one thousand of serum samples were obtained from different at risk categories of patients with the aim to investigate on the prevalence of anti-HIV antibodies in these populations. Also HIV antigen and HBV markers were investigated in the same people. Som
The acquired immunodeficiency syndrome (AIDS) is caused by the HIV infection in people with an already impaired immunological system. The seroprevalence follow-up of different markers of HIV should seem to suggest to predict the course of the disease as well as the T4/T8 ratio did. We examined 111 at risk anti-HIV pos
Inoue M; Sei Y; Kashiwagi S; Shingu T; Yokoyama MM; Department of Immunology, Kurume University School of Medicine,; Fukuoka, Japan.
We have detected inhibitory antibody against HIV-1 reverse transcriptase (RT) in the sera of HTLV-1 carriers, although the lack of immunological cross reaction between HIV-RT and other mammalian retroviruses, including HTLV-1, has been reported elsewhere (1). Sera from 72 HTLV-1 carriers in the southern part of Kyushu
Brodie SE; Friedman AH; Department of Ophthalmology, Mount Sinai Medical Center, New; York, NY 10029.
Three cases of patients with AIDS in whom severe retinal dysfunction preceded the development of widespread funduscopic abnormalities are presented. The disparity between the minimal extent of visible retinal lesions and the severe loss of retinal function was confirmed by visual field and electroretinographic studies
Lau RK; Goh BT; Estreich S; Cox SN; Levy I; London Hospital, Whitechapel.
Gonococcal eye infection in adults is an uncommon cause of blindness, where prompt diagnosis and effective treatment are essential in the prevention of ophthalmic morbidity. We present a case report detailing the management and complications encountered in this condition in a patient coinfected with human immunodefici
French MA; Cameron PU; Grimsley G; Smyth LA; Dawkins RL; Department of Clinical Immunology, Royal Perth Hospital, Western; Australia.
Twenty-four patients with various degrees of human immunodeficiency virus (HIV)-associated immunodeficiency were treated with zidovudine for up to 6 months. Nineteen of these patients had persistent depression of delayed-type hypersensitivity (DTH) responses prior to commencing therapy. In 11 of these 19 patients (58%
Wiley CA; Belman AL; Dickson DW; Rubinstein A; Nelson JA; Department of Pathology, University of California San Diego, La; Jolla 92093.
Infants and children with symptomatic human immunodeficiency virus (HIV) infection frequently develop neurologic disease with symptoms and signs of acquired microcephaly, developmental delays, encephalopathy, pyramidal tract signs, and less often, movement disorders and ataxia. However, clinical courses vary and, base
Bhat RA; Ulrich PP; Vyas GN; Department of Laboratory Medicine, University of California, San; Francisco 94143-0100.
Based on the diversity of nucleotide sequences of cloned hepatitis B virus DNA genomes, we have predicted possible replication of genetic variants of human hepatitis B virus. This prediction is exemplified by studies of a chronic carrier of HBsAg/adw2, who lacked anti-HBc but carried exceedingly high levels of hepatit
Walford N; Van der Wouw PA; Das PK; Ten Velden JJ; Hulsebosch HJ; Department of Pathology, Academic Medical Centre of the; University of Amsterdam, The Netherlands.
A rare vascular proliferation found as a skin lesion in patients suffering from the acquired immunodeficiency syndrome and sometimes referred to as epithelioid angiomatosis is believed to be a manifestation of infection by the cat scratch bacillus or a related organism. We describe the histological findings from eight
Shibata D; Hu E; Weiss LM; Brynes RK; Nathwani BN; Department of Pathology, Los Angeles County-University of; Southern California Medical Center 90033.
The present study was undertaken to establish the incidence of t(14;18) (q32:q21) chromosomal translocations detectable by a polymerase chain reaction (PCR) assay on fixed lymphoma biopsies. DNA samples from 113 formalin-fixed, paraffin-embedded tissue biopsies (non-Hodgkin s lymphomas, 96 cases; Hodgkin s disease, si
Int J Cancer. 1990 Mar 15;45(3):486-9. Unique Identifier : AIDSLINE MED/90170198
Balzarini J; Sobis H; Naesens L; Vandeputte M; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
9-(2-Phosphonylmethoxyethyl)adenine (PMEA), a potent inhibitor of human immunodeficiency virus (HIV), caused a dose-dependent suppression of tumor formation, and mortality associated therewith, in 6-day-old NMRI mice inoculated intracerebrally with Moloney murine sarcoma virus (MSV). Even at a dose as low as 1 mg/kg/d
Gessain A; Saal F; Giron ML; Lasneret J; Lagaye S; Gout O; De The G; Sigaux F; Peries J; UPR A0043 CNRS Retrovirus et Retrotransposons des Vertebres,; Hopital Saint-Louis, Paris, France.
Twelve long-term cell lines were established from peripheral blood mononuclear cells (PBMC) or cerebrospinal fluid cells of patients with human T lymphotropic virus type I (HTLV-1) seropositive tropical spastic paraparesis (TSP) originating from the French West Indies, French Guyana
Krivine A; Yakudima A; Le May M; Pena-Cruz V; Huang AS; McIntosh K; Division of Infectious Diseases, Children's Hospital, Boston, MA; 02115.
We report on an investigation designed to compare the polymerase chain reaction (PCR) with culture and p24 measurement for the diagnosis of human immunodeficiency virus (HIV) infection in infants and children. Forty-five children born of mothers with antibodies to HIV type 1 were studied; P24 antigen was measured in p
JAMA. 1990 Mar 16;263(11):1522-5. Unique Identifier : AIDSLINE MED/90172485
Bregman DJ; Langmuir AD; Department of Preventive Medicine, University of Southern; California, Los Angeles 90033.
Farr s Law of Epidemics, first promulgated in 1840 and resurrected by Brownlee in the early 1900s, states that epidemics tend to rise and fall in a roughly symmetrical pattern that can be approximated by a normal bell-shaped curve. We applied this simple law to the reported annual incidence of cases of acquired immuno
JAMA. 1990 Mar 23-30;263(12):1662-4. Unique Identifier : AIDSLINE MED/90172517
Engel JP; Englund JA; Fletcher CV; Hill EL; Department of Medicine, University of Minnesota, Minneapolis.
Two patients with acquired immunodeficiency syndrome who developed severe ulcerative proctitis caused by herpes simplex virus type 2 that was resistant to acyclovir were successfully treated with 6 weeks of high-dose, continuous-infusion acyclovir sodium (1.5 to 2.0 mg/kg per ho
Klin Wochenschr. 1990 Jan 4;68(1):12-7. Unique Identifier : AIDSLINE MED/90172976
Rieckmann P; Weber T; Felgenhauer K; Neurologische Klinik und Poliklinik der Universitat Gottingen.
An immunocytochemical technique allowing repeated use of antisera is applied to identify immunoglobulin-containing cells (ICC) of the IgG, IgA, and IgM class in the cerebrospinal fluid (CSF) of 298 patients with various neurological disorders. The demonstration of ICC in the CSF is highly indicative of an inflammatory
Krogsgaard K; Aldershvile J; Kryger P; Pedersen C; Andersson P; Dalboge H; Nielsen JO; Hansson BG; Department of Infectious Diseases, Hvidovre Hospital, University; of Copenhagen, Denmark.
Reactivation of hepatitis B virus replication was investigated in an unselected group of 44 HBV DNA negative, anti-HBe positive chronic HBsAg carriers. Twenty-five patients (54%) were intravenous drug addicts and 7 (16%) were male homosexuals. Sixteen patients had evidence of delta infection and five of the seven male
Md Med J. 1990 Jan;39(1):83-9. Unique Identifier : AIDSLINE MED/90173733
Horman JT; Israel E; van Blerk GA
From 1981 through 1987, a total of 1,068 AIDS cases were diagnosed in Maryland; 62.8 percent occurred in the homosexual/bisexual male cohort followed by intravenous drug abusers, 21.8 percent. Time trends suggest that proportionally fewer cases of AIDS will occur among homosexual/bisexual males and transfusion patient
Three Michigan doctors are taking promising new approaches to bring home the tough health care issues facing adolescents in the 1990 s--most importantly, AIDS. All three approaches, which range from a school-based clinic to a questionnaire, attempt to solve specific, and difficult problems--like HIV infection--by impr
Mo Med. 1990 Jan;87(1):19-22. Unique Identifier : AIDSLINE MED/90174055
Ettinger NA; Department of Medicine, Washington University School of Medicine,; St. Louis, Missouri.
As the AIDS epidemic has evolved, so have improvements been made in diagnosis and treatment of Pneumocystis carinii pneumonia, the most common opportunistic infection in AIDS. Advances, changes, and current research are discussed.
Mo Med. 1990 Jan;87(1):37-40. Unique Identifier : AIDSLINE MED/90174059
Chaplin H Jr; Ramos R; Department of Pathology, Washington University School of; Medicine, St. Louis, Missouri 63110.
Patients are likely to ask their physicians about the safety of blood transfusions in the present era of AIDS fear. The authors address these concerns and discuss the risks of acquiring viral disease from a transfusion.
N Engl J Med. 1990 Mar 22;322(12):821-5. Unique Identifier : AIDSLINE MED/90174241
DeBuono BA; Zinner SH; Daamen M; McCormack WM; Department of Medicine, Brown University, Providence, RI.
To compare sexual practices in college women before and after the start of the current epidemics of Chlamydia trachomatis, genital herpesvirus, and human immunodeficiency virus type 1 infection, we surveyed 486 college women who consulted gynecologists at a student health service in 1975, 161 in 1986, and 132 in 1989
Melroe NH; University of Minnesota, Minneapolis-St. Paul.
An ethical dilemma that health professionals working with HIV-infected clients currently face is the issue of maintaining patient confidentiality vs. the professional s duty to warn persons at potential risk for acquiring the virus. Multiple factors are involved when trying to resolve what a health professional s obli
Optom Vis Sci. 1990 Jan;67(1):19-21. Unique Identifier : AIDSLINE MED/90174708
Piccolo MG; Leach NE; Boltz RL; College of Optometry, University of Houston, Texas.
Because of the possibility of transmitting communicable diseases, in particular the HIV virus, it has been recommended that all diagnostic contact lenses, including rigid lenses, be disinfected after each use. Hydrogen peroxide is a recommended disinfection agent, but its effect on rigid lens polymers is relatively un
Mod Pathol. 1990 Jan;3(1):25-30. Unique Identifier : AIDSLINE MED/90175335
Cote RJ; Rosenblum M; Telzak EE; May M; Unger PD; Cartun RW; Department of Pathology, Memorial Sloan-Kettering Cancer Center,; New York, New York.
Pneumocystis carinii pneumonia is an important infection in the immunocompromised host, and the rate of symptomatic infections has risen dramatically with the advent of immunosuppressive therapies and infections with the human immunodeficiency virus (HIV). However, dissemination of P. carinii is thought to be an unusu
Mod Pathol. 1990 Jan;3(1):49-53. Unique Identifier : AIDSLINE MED/90175340
Dowell SF; Moore GW; Hutchins GM; Department of Pathology, Johns Hopkins Medical Institutions,; Baltimore, Maryland.
Clinical studies have indicated that pancreatitis is a common cause of morbidity in patients with acquired immunodeficiency syndrome (AIDS). In order to assess the morphologic basis of this pancreatic disease, we reviewed 82 autopsies performed on AIDS patients at The Johns Hopkins Hospital. Pancreatic lesions were de
Mod Pathol. 1990 Jan;3(1):64-70. Unique Identifier : AIDSLINE MED/90175344
Niedt GW; Myskowski PL; Urmacher C; Niedzwiecki D; Chapman D; Safai B; Department of Pathology, New York Hospital-Cornell Medical; Center, New York.
The original cutaneous biopsy specimens of 93 patients who presented themselves to the Memorial Sloan-Kettering Cancer Center with acquired immunodeficiency syndrome (AIDS)-related Kaposi s sarcoma (KS) were systematically reviewed for 23 histologic variables. KS was the initial manifestation of AIDS in all of the pat
Proc Natl Acad Sci U S A. 1990 Mar;87(5):1874-8. Unique Identifier : AIDSLINE MED/90175399
Guatelli JC; Whitfield KM; Kwoh DY; Barringer KJ; Richman DD; Gingeras TR; Department of Medicine, University of California San Diego School; of Medicine 92161.
A target nucleic acid sequence can be replicated (amplified) exponentially in vitro under isothermal conditions by using three enzymatic activities essential to retroviral replication: reverse transcriptase, RNase H, and a DNA-dependent RNA polymerase. By mimicking the retroviral strategy of RNA replication by means o
Proc Natl Acad Sci U S A. 1990 Mar;87(5):1917-21. Unique Identifier : AIDSLINE GENBANK/M31451
McNearney T; Westervelt P; Thielan BJ; Trowbridge DB; Garcia J; Whittier R; Ratner L; Department of Medicine, Washington University School of Medicine,; Saint Louis, MO 63110.
Human immunodeficiency virus type 1 isolates were obtained over a 3-year period from blood, brain, and lung of three patients in a clustered infectious outbreak. This included a blood donor who was initially asymptomatic but subsequently developed AIDS-related complex and two neonatal transfusion recipients who develo
Lawrence DN; Division of Host Factors, Centers for Disease Control, Atlanta,; GA 30333.
Seroconversion surveillance is informative and must be continued. The level of safety is now so high that individual candidate cases of seroconversion need exquisite investigation to exclude the possibility of another source of the HIV infection. Consequently, we must be mindful that the inappropriate assignment of an
Science. 1990 Mar 2;247(4946):1082-4. Unique Identifier : AIDSLINE MED/90176437
Jeang KT; Widen SG; Semmes OJ 4th; Wilson SH; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, MD 20892.
Human T cell leukemia virus type I (HTLV-I) is the etiological agent for adult T cell leukemia (ATL). The HTLV-I trans-activator protein Tax can activate the expression of its own long terminal repeat (LTR) and many cellular and viral genes. Tax down-regulated the expression of human beta-polymerase (hu beta-pol), a c
Science. 1990 Mar 2;247(4946):1084-8. Unique Identifier : AIDSLINE MED/90176438
Allan JS; Strauss J; Buck DW; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, TX 78284.
The CD4 receptor on human T cells has been shown to play an integral part in the human immunodeficiency virus type 1 (HIV-1) infection process. Recombinant soluble human CD4 (rCD4) was tested for its ability to inhibit SIVagm, an HIV-like virus that naturally infects African green monkeys, in order to define T cell su
Foster WF; Somerville MA; Duckett M; Faculty of Law, McGill University, Montreal, Quebec, Canada.
In general, there is a low incidence of HIV infection in members of school communities. Moreover, all available evidence supports the conclusion that HIV is not transmitted by the everyday contacts which occur in family, social, employment and educational settings. Despite this, the presence, in a school community, of
Walkey FH; Taylor AJ; Green DE; Department of Psychology, Victoria University of Wellington, New; Zealand.
Two propositions about attitudes, which have previously been supported with respect to the mentally ill, were examined with respect to AIDS patients. The first, that people attach a stigma to the AIDS patient, was strongly supported, and two quite independent components of the stigma were found. One of these component
AIDS is a notifiable disease in Austria . Until August 31, 1989, a total of 324 cases were recorded, with 145 deaths. Since 1988, the annual doubling of cases that was initially found is no longer observed. Centralization of confirmatory testing of samples that are positive in the
Kurtin PJ; McKinsey DS; Gupta MR; Driks M; Department of Pathology, Research Medical Center and Infectious; Disease Associates of Kansas City, Missouri.
In areas where Histoplasma capsulatum infections are endemic in the United States , there is an increasing frequency of progressive disseminated histoplasmosis (PDH) as an opportunistic infection in patients with acquired immune deficiency syndrome (AIDS). The bone marrow and peripheral
Am J Gastroenterol. 1990 Mar;85(3):296-8. Unique Identifier : AIDSLINE MED/90178050
Ezzell JH Jr; Bremer J; Adamec TA; Division of Gastroenterology, University of Tennessee, Memphis; Center for the Health Sciences.
Bacterial esophagitis is uncommon and has not been well characterized. We present a patient who fulfills the strict definition of bacterial esophagitis set forth by Walsh: histopathologically demonstrable bacterial invasion of esophageal mucosa or deeper layers with no concomitant fungal, viral, or neoplastic involvem
Johnson JE; Anders GT; Blanton HM; Hawkes CE; Bush BA; McAllister CK; Matthews JI; Pulmonary Disease Service, Brooke Army Medical Center, Fort Sam; Houston, TX 78234-6200.
To confirm the presence of exercise dysfunction in patients seropositive for the human immunodeficiency virus (HIV), 32 such patients without AIDS were evaluated with cardiopulmonary exercise testing, pulmonary function testing, bronchoalveolar lavage, chest roentgenography, and gallium scanning. No evidence of pulmon
Appl Environ Microbiol. 1990 Jan;56(1):264-8. Unique Identifier : AIDSLINE MED/90179161
Stinson MC; Galanek MS; Ducatman AM; Masse FX; Kuritzkes DR; Environmental Medical Service, Massachusetts Institute of; Technology, Cambridge.
A method is described for autoclaving low levels of solid infectious, radioactive waste. The method permits steam penetration to inactivate biologic waste, while any volatile radioactive compounds generated during the autoclave process are absorbed. Inactivation of radiolabeled infectious waste has been problematic be
Ann Thorac Surg. 1990 Mar;49(3):481-2. Unique Identifier : AIDSLINE MED/90179324
Egan TM; Maitland A; Sinave C; Pollick C; David TE; Department of Surgery, University of Toronto, Ontario, Canada.
A hemophiliac with acquired immunodeficiency syndrome-related complex was seen with sepsis related to a ventricular septal abscess. The abscess was debrided and the septum was patched with a single layer of autologous pericardium. The patient recovered and survived 6 months before dying of acquired immunodeficiency sy
Biochem Biophys Res Commun. 1990 Feb 28;167(1):1-8. Unique Identifier : AIDSLINE MED/90179733
Oka S; Urayama K; Hirabayashi Y; Ohnishi K; Goto H; Mitamura K; Kimura S; Shimada K; Department of Infectious Diseases, University of Tokyo, Japan.
A method for detecting human immunodeficiency virus type 1 (HIV-1) provirus DNA in lymphocytes with improved sensitivity and reproducibility was developed using the polymerase chain reaction (PCR). Amplified HIV-1 DNA was hybridized with a 32P-labeled probe and quantitated with a beta-scanner after electrophoresis. A
Biochem Biophys Res Commun. 1990 Feb 28;167(1):222-31. Unique Identifier : AIDSLINE MED/90179754
Cornet B; Vandenbranden M; Cogniaux J; Giurgea L; Dekegel D; Ruysschaert JM; Laboratoire de Chimie-Physique des Macromolecules aux; Interfaces, Universite Libre de Bruxelles, Belgium.
Purified Human Immunodeficiency Virus (HIV) was solubilized in octylglucopyranoside. After centrifugation, the supernatant was added to lipid-detergent mixed micelles. Formation of virosomes occurred during overnight dialysis. Centrifugation on a continuous glycerol gradient showed that envelope glycoproteins (gp120 a
D'Onofrio C; Alvino E; Garaci E; Bonmassar E; Santoro MG; Department of Experimental Medicine and Biochemical Sciences, II; University of Rome, Italy.
Type A prostaglandins (PGA1 and 16,16-dimethyl-PGA2-methyl ester) were found to block the proliferation of HTLV-I infected cord blood lymphocytes (CBL) in vitro, thus preventing the clonal immortalisation that is considered as a predisposing condition to HTLV-I positive leukaemia. PGA1 and di-M-PGA2 did not affect the
Blood. 1990 Mar 15;75(6):1267-72. Unique Identifier : AIDSLINE MED/90181613
Ragni MV; Bontempo FA; Myers DJ; Kiss JE; Oral A; Department of Medicine, University of Pittsburgh School of; Medicine, PA.
Clinical bleeding tendency and tests of immune function were studied prospectively in 11 human immunodeficiency virus (HIV)-infected hemophiliacs with immune thrombocytopenic purpura (ITP) and a platelet count less than 50,000/microL. These 11 patients represented 13% of a well-characterized cohort of 87 HIV + hemophi
Gellert GA; Durfee MJ; Berkowitz CD; UCLA School of Public Health.
The incidence of human immunodeficiency virus (HIV) infection acquired by children through sexual abuse is presently unknown. A telephone survey of 63 practitioners of pediatric sexual abuse (PSA) assessment in the five U.S. regions with highest prevalence of HIV infection was conducted to determine the present status
Can J Public Health. 1990 Jan-Feb;81(1):39-45. Unique Identifier : AIDSLINE MED/90182521
Bardsley J; Turvey J; Blatherwick J; North Health Unit, Vancouver, B.C.
To stem the spread of HIV among intravenous drug users, and between them and their sexual partners and offspring, Vancouver initiated a multifaceted ways and means needle exchange program in March of 1989. As of the end of October, over 2,600 users have registered. The needle exchange rate has increased steadily, reac
Can J Public Health. 1990 Jan-Feb;81(1):46-9. Unique Identifier : AIDSLINE MED/90182522
Millson M; Coates R; Devenyi P; Franklin T; Rankin J; Department of Preventive Medicine & Biostatistics, Faculty of; Medicine, University of Toronto, Ontario, Canada.
Ninety injection drug users (61 males, 29 females) attending the Addiction Research Foundation Clinical Institute completed an anonymous, self-administered questionnaire about their knowledge, attitudes and behaviour regarding Human Immunodeficiency Virus (HIV) infection. Sixty-two percent had used drugs for more than
Can J Public Health. 1990 Jan-Feb;81(1):50-2. Unique Identifier : AIDSLINE MED/90182523
Frank JW; Coates RA; Brant R; Garbutt JM; Department of Preventive Medicine and Biostatistics, Faculty of; Medicine, University of Toronto, Ontario, Canada.
Can J Anaesth. 1990 Mar;37(2):156-9. Unique Identifier : AIDSLINE MED/90182786
Trepanier CA; Lessard MR; Brochu JG; Denault PH; Departement d'Anesthesie, Hopital de l'Enfant-Jesus,; Universite Laval, Quebec.
The rate of blood contamination of IV tubings used in anaesthesia practice was investigated. Only IV tubings started in the operating room were studied. First, 300 tubings of three different types were tested at the three distal injection sites. The contamination rate was 3.3 per cent at the injection site closest to
Jones C; Orengo I; Rosen T; Ellner K; Baylor College of Medicine, Houston, Texas.
A forty-one-year-old homosexual man with acquired immunodeficiency syndrome (AIDS) and biopsy proven Kaposi s sarcoma of the oral cavity presented to our clinic with a several month history of violaceous papules and plaques on his trunk and extremities. Although the patient already carried a clinical diagnosis of Kapo
Beck DE; Jaso RG; Zajac RA; Department of General Surgery, Wilford Hall USAF Medical Center,; Lackland AFB, Texas 78236.
A retrospective review of 677 patients who tested positive for the human immunodeficiency virus, evaluated from January 1986 to February 1988, demonstrated 119 patients (18 percent) with anal condylomata. Demographics of these patients were similar to the total human immunodeficiency virus group; ages ranged from 19 t
EMBO J. 1990 Mar;9(3):957-64. Unique Identifier : AIDSLINE MED/90183997
Montagne J; Beraud C; Crenon I; Lombard-Platet G; Gazzolo L; Sergeant A; Jalinot P; UMR 49 CNRS-ENS, Ecole Normale Superieure de Lyon, France.
Activation of the HTLV-I promoter by the viral Tax1 transactivator is mediated by a 21 bp sequence motif imperfectly repeated three times and composed of three exactly conserved domains (A, B and C from 5 to 3 ). We show here that the Tax1 response requires the integrity of the B domain and of at least one of the fla
Of 44 children born to human immunodeficiency virus (type 1) (HIV)-infected mothers, 11 have become seronegative. After the loss of maternal antibodies all children were analysed for several immunological functions and virological parameters in order to determine their HIV status. All children to date are clinically h
FEBS Lett. 1990 Feb 26;261(2):339-42. Unique Identifier : AIDSLINE MED/90184475
Gobert B; Amiel C; Tang JQ; Barbarino P; Bene MC; Faure G; Laboratoire d'Immunologie, Faculte de Medecine, Universite de; Nancy, Vandoeuvre-les Nancy, France.
The expression of a molecule recognized by CD4 monoclonal antibodies was investigated on human sperm using immunolabelling, biochemical and immunochemical methods. Flow cytometry detected a significant fluorescence signal. SDS-PAGE analysis and Western blotting identified a molecule of 60 kDa, consistent with a CD4-li
Duclos B; Reimund JM; Lang JM; Coumaros G; Chamouard P; Lehr L; Baumann R; Koehl C; Weill JP; Service d'Hepato-Gastroenterologie et d'Assistance Nutritive,; CHU Hautepierre, Strasbourg.
To determine the degree of mononuclear blood cell activation in Crohn s disease (CD), 65 patients were prospectively investigated (22 with mild, 26 with moderate and 17 with severe disease). Serum levels of soluble receptors for interleukin-2 (SR- IL-2 ) were measured by
We report on our experience with 47 HIV-positive women, died in the meantime. 32% stated, that they had never taken i.v. drugs. Their clinical pattern varies greatly. Psychosocial problems and infections, such as genital herpes and candidosis and others predominate. Long-term co
Bottoni F; Gonnella P; Autelitano A; Orzalesi N; Institute of Biomedical Science, University Eye Clinic, S. Paolo; Hospital, Milano, Italy.
We examined a child with a human immunodeficiency virus (HIV) infection who at 15 months of age developed acute encephalitis, followed 1 week later by a diffuse, uniocular retinochoroiditis. The clinical picture in the right eye was characterized by the occurrence of some intraretinal hemorrhages; punctate, yellow-whi
Schleifer SJ; Keller SE; Franklin JE; LaFarge S; Miller SI; Department of Psychiatry, University of Medicine and Dentistry of; New Jersey-New Jersey Medical School, Newark 07103.
Mulhall BP; Fieldhouse S; Clark S; Carter L; Harrison L; Donovan B; Short RV; Burnet Clinical Research Unit, Walter and Eliza Hall Institute of; Medical Research, Melbourne.
The sera of 60 homosexual males were examined for the presence of antibodies to sperm using an indirect immunobead test (IBT). Six of 60 (10%) had antibodies of IgG isotype; in addition two of the six had antibodies of IgA isotype. The presence of antibodies was associated with the practice of unprotected receptive an
Alonso A; Montesino M; Iturralde MJ; Vallejo G; Sancho M; Tena G; Varela JM; Saiz A; Najera R; Instituto Nacional de Toxicologia, Madrid, Espana.
Group-specific component (GC) subtyping was performed by isoelectric focusing in 318 Spanish drug users at risk for infection or infected by HIV (85 HIV seronegatives, 111 HIV seropositives without symptoms, 89 seropositives with symptoms, 33 AIDS patients) and 187 healthy individuals. There was no significant associa
Ponka A; Helsinki City Health Department, Finland.
The number of new serologically diagnosed HIV infections has decreased in Helsinki since 1986. The clinical search for infections was started in 1983 and the serodiagnostic search in late 1984. The maximum yearly number of new HIV infections was 40 cases in 1986. In 1987 and 1988 the corresponding numbers were 31 and
As the HIV epidemic spreads, throughout the United States , and as an increasing number of persons become infected with the virus and manifest its many complications, more and more physicians are being asked to give presentations on HIV disease to professional and community groups. This
DeLaney AR; Damato RA; Ikeda CJ; Bothin Burn Center, St. Francis Memorial Hospital, San Francisco,; CA 94109.
Two cases that show delayed autograft loss secondary to late polymicrobial infection in patients whose test results are positive for the human immunodeficiency virus (HIV-positive patients) are presented. Mechanisms of immune dysfunction in HIV-positive patients are reviewed, and speculation on the possible contributi
Katz P; Yeager H Jr; Whalen G; Evans M; Swartz RP; Roecklein J; Division of Rheumatology, Immunology and Allergy, Georgetown; University School of Medicine, Washington, D.C. 20007.
Since the precise mechanism of host responses to infection with Mycobacterium-avium complex (MAC) is unclear and since cytotoxic lymphocytes may be involved in the destruction of cells infected with intracellular pathogens, we investigated the ability of normal peripheral blood lymphocytes to kill MAC-infected monocyt
Babu K; Sonnenberg M; Kathpalia S; Ortega P; Swiatlo AL; Kocka FE; Division of Infectious Disease, Cook County Hospital, Hektoen; Institute for Medical Research, Chicago, Illinois 60612.
Salmonella arizonae and other Salmonella serovars were isolated from four different rattlesnake preparations which were used for self-treatment of various diseases. A case of disseminated S. arizonae infection is reported in a patient who had acquired immunodeficiency syndrome and ingested dried rattlesnake.
Harris PE; Strba-Cechova K; Rubinstein P; Mann D; King DW; Suciu-Foca N; Department of Pathology, College of Physicians and Surgeons,; Columbia University, New York 10032.
Human immunodeficiency virus (HIV) infection is associated with a profound impairment of T cell function. Hence, enhancement of T cell reactivity to viral and bacterial antigens is important in the treatment of patients with AIDS. To develop tools for amplifying T cell reactivity, we have immunized mice with human hel
Francis ND; Logan RP; Walker MM; Polson RJ; Boylston AW; Pinching AJ; Harris JR; Baron JH; St Mary's Hospital, London, Department of Histopathology.
Fifty one patients with human immuno-deficiency virus (HIV-1) infection who had been consecutively endoscoped for upper gastrointestinal symptoms were biopsied (stomach or duodenum, or both) and compared with 59 age and sex matched controls for the presence of Campylobacter pylori. In 28 (47%) of the control group but
Fan DP; Shaffer CL; Department of Genetics and Cell Biology, University of Minnesota,; St. Paul.
This study used computer content analysis of written essays to explore university students knowledge and attitudes about AIDS. Because the essays were long, averaging 650 words each, and were on the very general topics of what individuals and society should do about AIDS, it was possible to study a wide variety of su
A population-based serosurvey of human immunodeficiency virus in Belle Glade, FL, enabled evaluation of risk factors for hepatitis B virus (HBV) infection in this racially mixed community. Serum samples from 725 adults and 130 children were tested for markers of HBV infection, and histories of exposure to HBV were obt
Kashiwagi S; Kajiyama W; Hayashi J; Noguchi A; Nakashima K; Nomura H; Ikematsu H; Sawada T; Kida S; Koide A; Department of General Medicine, Kyushu University Hospital,; Fukuoka, Japan.
To investigate the physiologic significance of antibody to human T cell leukemia virus type 1 (HTLV-1) tax gene product (p40tax), 147 male and 243 female HTLV-1 carriers were examined for anti-p40tax, and 104 carriers were checked for anti-p40tax an average of 5.4 times during an 8-year period. Prevalence of anti-p40t
Lifson AR; Stanley M; Pane J; O'Malley PM; Wilber JC; Stanley A; Jeffery B; Rutherford GW; Sohmer PR; Department of Public Health, AIDS Office, San Francisco, CA; 94102.
The polymerase chain reaction (PCR) for human immunodeficiency virus type 1 (HIV-1) DNA was performed on specimens from 197 homosexual and bisexual men enrolled in studies of HIV-1 infection. Thirty cycles of amplification were conducted, followed by detection with probes corresponding to two gag primer pairs (SK 38/3
Elliott B; Brunham RC; Laga M; Piot P; Ndinya-Achola JO; Maitha G; Cheang M; Plummer FA; Department of Medicine, University of Manitoba, Winnipeg, Canada.
With the objective of determining if specific sexually transmitted diseases (STDs) are associated with prematurity (birth weight less than or equal to 2500 g and gestational age less than or equal to 36 weeks), a case-control study was conducted to evaluate women for serologic evidence of syphilis and human immunodefi
Hickey SA; Buckley JG; Macartney JC; Department of ENT Surgery, St Thomas' Hospital, London.
A case of symptomatic recurrent adenoidal hypertrophy, as the presenting feature of HIV infection in a haemophiliac child, is reported. The incidence of non-malignant nasopharyngeal lymphoid hyperplasia in HIV infection is examined and the relevance of the histological appearance is discussed in relation to progressio
An immunoglobulin preparation for oral use was prepared from pooled bovine colostrum from more than 100 animals. The preparation has high antibacterial antibody titres, and a high capacity for the neutralization of bacterial toxins. It is well tolerated and highly effective in the treatment of severe diarrhoea, e.g. i
Scherberich JE; Birk HW; Schoeppe W; Abt. Nephrologie, Klinikum der Johann W. Goethe-Universitat,; Frankfurt am Main.
As a contribution to the noninvasive diagnosis of kidney damage, polyclonal antisera specifically directed against brush border surface glycoproteins of the proximal tubule of the human kidney were used in radioimmunoblotting studies for the assessment of kidney-tissue proteinuria. Urine specimens from healthy control
To obtain a detailed understanding of the various factors influencing the polymerase chain reaction, we optimized parameters such as ion concentration, pH, primer sequence and concentration, hybridization stringency, cycle numbers, etc. Using 3 different plasmids (2 HIV2 clones and pUC18) and several genomic DNA sampl
J Med Virol. 1990 Feb;30(2):103-6. Unique Identifier : AIDSLINE MED/90188325
Scott JS; Pan PE; Pace RA; Sloots TP; Cooksley WG; Department of Biochemistry, University of Queensland, Royal; Brisbane Hospital, Australia.
Sera from 20 Chinese patients with chronic hepatitis B were examined for hepatitis B e antigen and hepatitis B virus (HBV) DNA. There was considerable discordance with HBV DNA not being detectable in 10 out of 13 (77%) patients who were hepatitis B e antigen positive. Further testing for anti-HBe and HBV-DNA polymeras
Lopez TM; Hagemeister FB; McLaughlin P; Velasquez WS; Swan F; Redman JR; Rodriguez MA; Tucker SL; Silvermintz K; Johnson J; et al; Department of Hematology, University of Texas MD Anderson Cancer; Center, Houston 77030.
Small noncleaved cell lymphoma (SNCCL), a rare lymphoma in adults, is associated with not only a rapid complete response (CR) to chemotherapy but also with the potential to rapidly relapse both systemically and in the CNS. We treated 44 assessable adults with two similar protocols, consisting of three sequential chemo
Reddy MM; Grieco MH; R.A. Cooke Institute of Allergy, St. Luke's-Roosevelt Hospital; Center, New York, NY 10019.
Circulating immune complexes were quantitated in asymptomatic intravenous drug abusers (IVDA), male homosexuals, and patients with lymphadenopathy or acquired immunodeficiency syndrome (AIDS) by two different methods. Circulating immune complexes were elevated in HIV-seronegative IVDAs and male homosexuals, probably r
This study was conducted to assess knowledge of and attitudes toward AIDS in primary grade teachers and students before the implementation of a mandated AIDS curriculum. Teachers and children completed questionnaires. Although both the teachers and the children were knowledgeable about some aspects of AIDS, both group
Gail MH; Rosenberg PS; Goedert JJ; National Cancer Institute, Epidemiology and Biostatistics; Program, Rockville, MD 20892.
Since the middle of 1987, fewer consistently defined AIDS cases have been reported than expected among homosexual and bisexual men in the United States . This AIDS deficit was greater among homosexual and bisexual men in New York City, San Francisco, and Los Angeles, but was also striki
Marmor M; Krasinski K; Sanchez M; Cohen H; Dubin N; Weiss L; Manning A; Bebenroth D; Saphier N; Harrison C; et al; Department of Environmental Medicine, New York University Medical; Center, New York.
Persons attending outpatient clinics at Bellevue Hospital Center in Manhattan, New York City were invited to be tested for antibodies to human immunodeficiency virus (HIV). In pretest counseling, males were asked if they had injected nonprescription drugs or engaged in sex with other men since January 1, 1977; if so,
Merino N; Sanchez RL; Munoz A; Prada G; Garcia CF; Polk BF; Fundacion Santa Fe de Bogota, Colombia.
From October 1985 to November 1987, a sample of 294 Colombian homosexual men volunteered to answer a questionnaire on sexual practices and consented to HIV-1 testing. Testing for HIV-1 was performed using an ELISA and those positive were confirmed with envelope- and core-specific ELISAs. Statistical methods for data a
Skoutelis AT; Murphy RL; MacDonell KB; VonRoenn JH; Sterkel CD; Phair JP; Department of Medicine, Northwestern University Medical School,; Chicago, Illinois 60611.
Indwelling central venous catheters are increasingly useful in the clinical management of patients with acquired immune deficiency syndrome (AIDS). To evaluate the risk of catheter infection in this group of patients, we reviewed the records of 299 patients with Hickman and Port-a-cath catheters. Patients were stratif
Hosoi S; Borsos T; Dunlop N; Nara PL; Laboratory of Immunobiology, National Cancer Institute, FCRF,; Frederick, MD 21701-1013.
We studied inactivation of HIV-1 by fresh sera of animals. We found that while fresh sera of humans and chimpanzees (among others) did not have antiviral activity, fresh sera of several other mammals, especially those of rodents and felines, showed a dose-dependent viral-inactivating property against cell-free HIV-1;
Casriel C; Des Jarlais DC; Rodriguez R; Friedman SR; Stepherson B; Khuri E; Narcotic and Drug Research, Inc., New York City.
Preventing illicit drug injection would be the ideal point for preventing HIV infection and AIDS among illicit drug injectors. This paper reports on clinical issues that arose in a program for intranasal (sniffer) heroin users who were at high risk of injecting drugs. Extensive field notes were kept by the staff of th
Med Care. 1990 Mar;28(3):251-60. Unique Identifier : AIDSLINE MED/90190019
Rizzo JA; Marder WD; Willke RJ; National Center for Health Services, Research and Health Care; Technology Assessment, Rockville, Maryland 20857.
The growing population of HIV-seropositives raises serious concerns about who will provide medical care to this group. This article presents the first national estimates of physician involvement in, and attitudes toward, the treatment of HIV-seropositive patients. Nearly 50% of the nonfederal patient care physicians i
A 7-year-old boy with severe hemophilia B suffered an intraspinal extradural hemorrhage without preceding trauma. Since the age of 3 years the patient is HIV-1 positive. The actual hemorrhage caused a strong pain in the thoracolumbar area without signs of spinal cord compression. It was diagnosed by CT-scan. By early
Ned Tijdschr Geneeskd. 1990 Mar 10;134(10):495-7. Unique Identifier : AIDSLINE MED/90190919
van der Ende ME; Kroes AC; Buitenwerf J; van der Poel CL; Afd. Inwendige Geneeskunde, Academisch Ziekenhuis; Rotterdam-Dijkzigt.
In four patients in Rotterdam AIDS was diagnosed, and it was subsequently demonstrated that they were infected with HIV type 2. One of the patients was an immigrant from the Cape Verde islands, two of the others had heterosexual contacts with persons of this area, and the fourth
Ned Tijdschr Geneeskd. 1990 Feb 24;134(8):390-4. Unique Identifier : AIDSLINE MED/90190932
Bindels PJ; Jong JT; Poos MJ; Leentvaar-Kuijpers A; Jager JC; Coutinho RA; Gemeentelijke Geneeskundige en Gezondheidsdienst, sector; Volksgezondheid en Milieu, Amsterdam.
The results are reported of AIDS monitoring in Amsterdam in the period 1982-1988. Males with homosexual contacts are the principal risk group followed by the fast-growing group of users of intravenous drugs. Transmission of the human immunodeficiency virus to the heterosexual population will occur mostly via sexual co
Simpson DM; Bender AN; Farraye J; Mendelson SG; Wolfe DE; Department of Neurology, Mount Sinai Medical Center, New York,; NY.
We evaluated 5 patients with the diagnosis of HIV wasting syndrome. None had severe diarrhea or other causes for malabsorption. All had myopathy by clinical, laboratory, and muscle biopsy criteria. Withdrawal of azidothymidine in 3 patients did not lead to improvement. Corticosteroid therapy was effective in 3 patient
Feraru ER; Aronow HA; Lipton RB; Department of Neurology, Albert Einstein College of Medicine,; Bronx, NY.
We report 2 HIV-seropositive patients with neurosyphilis whose initial CSF VDRL tests were negative. The CSF VDRL became positive after 12 days of IV penicillin treatment for syphilitic meningitis in the 1st patient. The 2nd patient developed syphilitic polyradiculopathy and a positive CSF VDRL 3 months after treatmen
N Y State J Med. 1990 Mar;90(3):123-6. Unique Identifier : AIDSLINE MED/90191360
Harris RE; Langrod J; Hebert JR; Lowinson J; Zang E; Wynder EL; American Health Foundation, New York, NY 10017.
Forty newly admitted patients to a methadone treatment clinic in New York City were interviewed to assess their patterns of intravenous (IV) drug abuse, sexual activity, and other risk behaviors for the acquired immunodeficiency syndrome (AIDS). The study revealed a marked decline in needle sharing since 1984 (46% to
N Y State J Med. 1990 Mar;90(3):126-8. Unique Identifier : AIDSLINE MED/90191361
Chang HG; Murphy D; Diferdinando GT Jr; Morse DL; Bureau of Communicable Disease Control, New York State Department; of Health, Albany 12237.
A 1988 survey regarding the level of knowledge about acquired immunodeficiency syndrome (AIDS) among 505 clients of sexually transmitted disease (STD) clinics demonstrated 80% correct responses. However, 13% thought AIDS could be transmitted via sharing utensils, and 51% were unaware that acquiring another STD could i
N Y State J Med. 1990 Mar;90(3):129-33. Unique Identifier : AIDSLINE MED/90191362
Ruder AM; Flam R; Flatto D; Curran AS; Division of Planning and Evaluation, Westchester County Health; Department, White Plains, NY 10601.
From 1986 through mid-1988, the Westchester County (NY) Health Department made AIDS education presentations upon request to junior and senior high school students and to adult educators and supervisors. In 1987, an evaluation component was added to measure the effectiveness of the presentations in increasing knowledge
N Y State J Med. 1990 Mar;90(3):133-8. Unique Identifier : AIDSLINE MED/90191363
Morse DL; Truman BI; Hanrahan JP; Mikl J; Broaddus RK; Maguire BH; Grabau JC; Kain-Hyde S; Han Y; Lawrence CE; Bureau of Communicable Disease Control, New York State Department; of Health, Albany 12237.
During the last five years, AIDS has become the preeminent health care problem in New York State correctional facilities. Through December 31, 1988, 915 cases of AIDS had been diagnosed among inmates. This represented approximately 1% of the cumulative AIDS cases in the United States ,
N Y State J Med. 1990 Mar;90(3):139-42. Unique Identifier : AIDSLINE MED/90191364
Pincus SH; Schoenbaum EE; Webber M; Department of Social Medicine, Montefiore Hospital and Medical; Center, Bronx, NY 10467.
The prevalence of human immunodeficiency virus (HIV) infection among adults who are mentally retarded is not known. Policies for those in residential settings are being established despite incomplete information. Knowledge regarding HIV seroprevalence would enable administrators to make more effective policy decisions
Safrin S; Dattel BJ; Hauer L; Sweet RL; Department of Medicine, University of California, San Francisco.
As the number of women with acquired immunodeficiency syndrome (AIDS) continues to rise in the United States , it becomes important to target preventive interventions as effectively as possible toward those groups at highest risk of acquiring human immunodeficiency virus (HIV) infection
Seltzer V; Benjamin F; Department of Obstetrics and Gynecology, Queens Hospital Center,; Long Island Jewish Medical Center, Jamaica, New York.
There is evidence to suggest that the human immunodeficiency virus (HIV) can be transmitted from mothers to their uninfected offspring via infected breast milk. The quantitative risk of transmission by this route is unknown. We must urge all individuals at risk for HIV infection to be tested. In the
Williams CA; Winkler JR; Grassi M; Murray PA; Department of Stomatology, University of California, San; Francisco.
This report describes a case of HIV-associated periodontitis complicated by necrotizing stomatitis in a homosexual male patient with AIDS. Necrotizing stomatitis is a rapidly progressive ulcerative and necrotic infection that causes massive destruction of the oral tissues and underlying bone. Like HIV periodontitis, i
Glick M; Pliskin ME; Weiss RC; Infectious Disease Center, Temple University School of Dentistry,; Philadelphia, Pa.
Human immunodeficiency virus-associated gingivitis (HIV-G) has been described recently as a clinical entity in HIV-infected patients. However, little is known about the etiology and pathogenesis of this condition. We report a case of HIV-G in a 32-year-old man with acquired immunodeficiency syndrome (AIDS). The histol
Orv Hetil. 1990 Mar 11;131(10):503-5. Unique Identifier : AIDSLINE MED/90191669
Peter S; Kollar L; Kiss T; Rozsos I; Pecsi Orvostudomanyi Egyetem, I. Sebeszeti Klinika.
Use of autotransfusion has recently come into the limelight of clinical practice especially because of the AIDS-risk and financial considerations. Authors have analysed data of 20 patients with peripheral arterial disease at whom hemodilution were carried out before the operation with the aim of using autotransfusion.
The human T-cell leukemia virus type I (HTLV-I) promoter contains three copies of imperfect repeats of a 21-base pair sequence designated here as TRE (Tax-response element) that is responsive to the virally encoded transactivator protein Tax. We have identified and separated four nuclear proteins from C81-66-45 cells,
Royce LA; Rossignol PA; Department of Entomology, Oregon State University, Corvallis; 97331-2907.
We demonstrate, by truncating the expected negative binomial distribution, that the tracheal mite parasite, Acarapis woodi, causes mortality in the European honey bee, Apis mellifera, but, that this mortality can be documented only during periods of low mite densities (mites per bee). At high mite densities, this tech
Bell NK; Department of Philosophy, School of Medicine, University of South; Carolina, Columbia.
For someone seeking to understand the ethical dimensions of trauma nursing, it quickly becomes apparent that there is a uniquely complex set of issues to be examined in this context. Many of these issues are made more difficult by the fact that the provider/patient relationship that undergirds the moral dimension of p
Proc Natl Acad Sci U S A. 1990 Mar;87(6):2379-83. Unique Identifier : AIDSLINE MED/90192811
Oyaizu N; Chirmule N; Kalyanaraman VS; Hall WW; Pahwa R; Shuster M; Pahwa S; Department of Pediatrics, North Shore University Hospital-Cornell; University Medical College, Manhasset, NY 11030.
Envelope glycoprotein gp120 of human immunodeficiency virus type 1 (HIV-1) is known to inhibit T-cell function, but little is known about the mechanisms of this immunosuppression. Pretreatment of a CD4+ tetanus toxoid-specific T-cell clone with soluble gp120 was found to exert a dose-dependent inhibition of soluble an
Chrysikopoulos HS; Press GA; Grafe MR; Hesselink JR; Wiley CA; Department of Radiology, University of California, San Diego; School of Medicine 92103.
To determine the computed tomographic (CT) and magnetic resonance (MR) imaging manifestations of central nervous system (CNS) infection by the human immunodeficiency virus (HIV), the authors analyzed the results of imaging of the CNS in 24 patients with HIV encephalitis confirmed at autopsy. Careful pathologic correla
Schweiz Med Wochenschr. 1990 Mar 10;120(10):335-8. Unique Identifier : AIDSLINE MED/90193620
Chave JP; Juvet A; Maziero A; Francioli P; Departement de medecine interne, CHUV, Lausanne.
From 1 July to 31 December 1988 risk factors for HIV infection were systematically recorded for all individuals tested anonymously at our institution and compared with similar data observed when anonymous testing was introduced (1985-1986). The absolute number of homosexuals and intravenous drug abusers remained stabl
de Roche R; Luscher NJ; Zimmerli W; Klinik fur Kiefer-, Plastische und Wiederherstellende Chirurgie,; Universitatsspital Basel.
The case of a 33-year-old HIV-positive patient who suffered from second- and third-degree burn injuries involving 30% of the body surface is reported. She was treated by early tangential excision of the burnt skin and split-thickness mesh grafting. The burn wounds healed without complications within the usual time, wi
Campbell CA; Department of Sociology, California State University, Long Beach; 90840.
This article describes the epidemiology of acquired immunodeficiency syndrome (AIDS) in women in the United States . Comparisons of female and male transmission categories are made and emphasis is placed on the heterosexual transmission and undetermined risk categories for women. Since
Brendstrup E; Schmidt K; Department of Epidemiology, Statens Seruminstitut, Copenhagen,; Denmark.
This paper describes how the threat of HIV infection is appraised and coped with by homosexual and bisexual men. Very little is known about men who do not want to be HIV tested, thus non-HIV-tested homosexual and bisexual men have been interviewed in depth about themes concerning their lives during the AIDS epidemic.
Herlitz C; Brorsson B; Department of Social Medicine, University of Uppsala, Sweden.
This study compares police officers and registered nurses and the general public concerning their perceptions of the risk of HIV infection, attitudes toward HIV-infected individuals, and attitudes toward measures used to fight the AIDS epidemic. Information was obtained through mail questionnaires sent to random sampl
Wiener LS; Siegel K; HIV Psychosocial Support Program, National Cancer Institute,; Bethesda, MD 20892.
With the steadily increasing number of people infected with the human immunodeficiency virus, social workers are being called on to play a key role in meeting the complex psychosocial needs of infected individuals and their significant others. To understand more about social workers levels of comfort in providing ser
South Med J. 1990 Mar;83(3):303-7. Unique Identifier : AIDSLINE MED/90193824
Uzych L
Testing for the presence of human immunodeficiency virus (HIV) antibodies creates a legal conflict between the individual s right to autonomy and privacy versus society s right to control the public health. A body of laws exists to address these conflicting rights. These laws, however, must evolve so as to strike a be
South Med J. 1990 Mar;83(3):322-4. Unique Identifier : AIDSLINE MED/90193829
Judson MA; Postic B; Division of Pulmonary and Critical Care Medicine, University of; South Carolina School of Medicine, Columbia 29208.
We have described the case of a patient with AIDS in whom a chylothorax developed, probably as a result of lymphatic obstruction from KS. This case emphasizes that the loss of proteins, fats, and lymphocytes into chylous pleural effusions can be particularly devastating in AIDS patients, who have profound nutritional
Ness PM; Douglas D; Koziol D; Harper M; Munoz A; Polk BF; American Red Cross Blood Services-Chesapeake Region, Baltimore,; Maryland.
Blood banks have intensified their efforts to discourage donations from individuals at risk for the human immunodeficiency virus (HIV-1). Since the onset of HIV-1 donor screening in April 1985, a marked reduction in seroprevalence has been seen at the authors institutions: from 51 cases per 100,000 donors in 1985 to
Samson S; Busch M; Ward J; Garner J; Salk S; Fernando L; Holland P; Rutherford G; Benjamin R; Perkins H; Irwin Memorial Blood Centers, San Francisco, California.
An expanded look-back program has been developed, in which patients who may have been exposed to HIV through blood transfusion were identified via three triggers: the blood that they received was donated by persons who 1) have subsequently been reported to local health departments as meeting the diagnostic criteria fo
Windolf J; Inglis R; Wesch M; Rueger JM; Pannike A; Klinikum der Johann-Wolfgang-Goethe-Universitat Frankfurt.
From January 1st, 1984 until December 31st, 1988 586 employees of the University Clinic of Frankfurt, West- Germany , were treated after occupational accidents with potentially HIV-contaminated materials. The majority of the patients were admitted because of lacerations that occurre
Union Med Can. 1990 Jan-Feb;119(1):31-4. Unique Identifier : AIDSLINE MED/90194462
Goyette M; Vincelette J; Hopital Saint-Luc, Montreal, Quebec.
Human immunodeficiency virus (HIV) antigens can be detected during early infection but usually disappear afterwards. Their later reappearance in serum seems to herald a greater virus replication and a poor prognosis. The prognostic value of antigen detection at the first clinical visit was assessed among 37 symptomati
Visani G; Re MC; Colombini R; Cenacchi AR; Tosi P; Furlini G; Sermasi G; Ricci P; Fogli M; Zucchelli P; et al; L. and A. Seragnoli Institute of Haematology, University of; Bologna, Italy.
We report the results of a survey of a total of 553 intravenous drug users (IVDUs) investigated at the drug addiction out-patient unit of the Psychiatric Department of Vienna University for antibodies to human immunodeficiency virus (HIV-1) using both enzyme-linked immuno sorbent and Western blot assays. HIV-1 antibod
Burnett RJ; Reents SB; Department of Pharmacy, Saint Francis Hospital, Blue Island, IL; 60406.
The use of pentamidine for treating Pneumocystis carinii pneumonia in AIDS patients has increased the awareness of pentamidine-induced adverse reactions. We report a case of severe hypomagnesemia and concurrent hypocalcemia that occurred during therapy with intravenous pentamidine. Pentamidine therapy was subsequently
Cope J; AIDS Secretariat, Medical Research Council, London, UK.
The UK Medical Research Council initiated a Directed Programme, aimed at developing vaccines for prevention and drugs for treatment of HIV infection and AIDS, in April 1987. This is a single collaborative research programme encompassing work in about 100 UK laboratories together with a small number in Europe and the U
Am J Hematol. 1990 Apr;33(4):230-3. Unique Identifier : AIDSLINE MED/90195982
Bello JL; Burgaleta C; Magallon M; Herruzo R; Villar JM; Hospital La Paz, Servicio de Hematologia, Madrid, Spain.
Hematological abnormalities are common in patients with AIDS or AIDS-related complex. We studied cytological characteristics in peripheral blood and bone marrow samples of 33 hemophilic patients with HIV Infection and in six HIV negatives. The HIV-positive patients presented leukopenia (60.6%), thrombocytopenia (69.9%
Am J Med Sci. 1990 Mar;299(3):158-63. Unique Identifier : AIDSLINE MED/90196066
Musher DM; Watson DA; Nickeson D; Gyorkey F; Lahart C; Rossen RD; Medical Service, Veterans Administration Medical Center, Houston,; Texas 77030.
Pulmonary alveolar macrophages (PAM) play a central role in host defense against pulmonary infection. The authors studied the number, viability, and ultrastructure of PAM recovered by bronchoalveolar lavage from normal and HIV-infected subjects, and their ability to phagocytose and kill Staphylococcus aureus. PAM from
Vincent TA; Schkade JK; Occupational Therapy, Texas Woman's University, Dallas.
In this pilot study, knowledge regarding AIDS was tested in 36 occupational therapy students and 33 education students. Also measured were the students attitudes toward AIDS patients and the resulting health care controversies. An analysis of the results revealed no significant differences in knowledge between the tw
Atchison BJ; Beard BJ; Lester LB; Department of Associated Health Professions, Eastern Michigan; University, Ypsilanti.
This study explored the attitudes, knowledge, and fears of occupational therapists and certified occupational therapy assistants regarding AIDS and HIV. The 119 respondents scores related to knowledge and fear revealed that many had significant fears about AIDS, which in turn may inhibit their willingness to care fori
Weinstein BD; Department of Occupational Therapy, University of Puget Sound,; Tacoma, Washington 98416.
This article presents a definition of HIV disease as a four-stage process. The Sickness Impact Profile (SIP) (Bergner, Bobbitt, Carter, & Gilson, 1981) was used to measure behavioral dysfunction in a sample of 15 persons with Stage 3 or Stage 4 (symptomatic) HIV disease. The areas of work, leisure, cognitive behavi
Weinstein BD; De Neffe LS; Department of Occupational Therapy, University of Puget Sound,; Tacoma, Washington 98416.
This article describes the blood clotting disorder of hemophilia, including its transmission, incidence, and physical and psychosocial effects. The epidemiology of persons with both hemophilia and HIV are discussed, as well as HIV s rapid spread due to contaminated blood products and the mechanisms commonly used to co
Gutterman L; Village Nursing Home's AIDS Day Treatment Program, New York, New; York 10011.
This paper describes the Village Nursing Home s day treatment program for persons with AIDS, with an emphasis on the role of occupational therapy and the outcomes of occupational therapy interventions. The clients demographics are included, and a general program philosophy of clients empowerment is discussed. The hee
Hansen RA; American Occupational Therapy Association's Standards and Ethics; Commission, Eastern Michigan University, Ypsilanti 48197.
Health care professionals encounter many ethical issues in the care of persons who are HIV positive or who have been diagnosed as having AIDS. Such issues include the allocation of scarce resources for research and health care; the use of various methods of disease control, including mandatory testing, forced isolatioe
AIDS presents difficult and unprecedented legal problems. Because modern law requires that persons with disabilities or illnesses be integrated into the mainstream of society, past responses to those with communicable diseases are no longer acceptable. Laws dealing with AIDS patients will have to evolve gradually and e
Anderson J; Hinojosa J; Bedell G; Kaplan MT; Occupational Therapy Program, College of Health Related; Professions, State University of New York, Brooklyn 11203-2098.
This article discusses occupational therapy for children with perinatal HIV infection and their care-givers. An interdisciplinary early intervention and preschool program serving these children is described. Current medical and neurological research is reviewed to serve as a basis for occupational therapy interventione
HIV infection affects all aspects of a person s occupational functioning. This article examines the application of the Model of Human Occupation (Kielhofner & Burke, 1980) to adults with HIV. An occupational therapy assessment battery based on the model is introduced. Given the physical, psychosocial, and environme
Piemme JA; Bolle JL; Clinical Nursing Educator, National Institutes of Health,; Bethesda, Maryland.
AIDS has or will affect virtually every professional health care provider. Occupational therapists are in a key position to identify and intervene with the social and occupational changes and losses commonly experienced by this patient population. Suggestions are provided to assist occupational therapists in helping p
Peloquin SM; Occupational Therapy, School of Allied Health Sciences,; University of Texas Medical Branch, Galveston 77550.
AIDS evokes powerful feelings, often manifestations of fear, among health care providers. To effectively treat patients with AIDS, occupational therapists must acknowledge and reconcile their personal feelings. One way to formulate a compassionate response to patients is to understand the meanings that we give to AIDS
Am J Public Health. 1990 Apr;80(4):405-10. Unique Identifier : AIDSLINE MED/90196411
Kelley PW; Miller RN; Pomerantz R; Wann F; Brundage JF; Burke DS; Division of Preventive Medicine, Walter Reed Army Institute of; Research, Washington, DC 20307-5100.
Between October 1985 and June 1989, most active duty US Army soldiers were screened for human immunodeficiency virus (HIV) antibody. Of 648,032 screened soldiers in this analysis, 1,588 were HIV-antibody positive. In a multivariate analysis, correlates of positivity included: age [Adjusted Odds Ratios (ref less than 2
Am J Public Health. 1990 Apr;80(4):416-8. Unique Identifier : AIDSLINE MED/90196413
Kelly JA; St. Lawrence JS; Brasfield TL; Stevenson LY; Diaz YE; Hauth AC; Department of Psychiatry and Human Behavior, University of; Mississippi Medical Center, Jackson 39216.
Men entering gay bars in three small southern cities were administered questionnaires to assess AIDS (acquired immunodeficiency syndrome) risk knowledge, perceived norms concerning the social acceptability of AIDS risk precautions, and personal sexual behavior. Seventy-seven percent (N = 355) of male patrons completed
We report here a summary of the data obtained from two HIV-1 antibody counseling and testing sites in Minneapolis-St. Paul for the first 48 months of operation (24,911 persons tested). The HIV-1 antibody seroprevalence rate for all persons tested was 5 percent. The highest seroprevalence rates were in male homosexual/
Am J Public Health. 1990 Apr;80(4):460-2. Unique Identifier : AIDSLINE MED/90196423
Stein ZA; HIV Center for Clinical and Behavioral Studies, New York State; Psychiatric Institute, NY 10032.
Efforts to prevent heterosexual transmission of HIV (human immunodeficiency virus) infection have thus far focused on modifying sexual behaviors and the use of condoms. While the experience of family planners, particularly in those countries most threatened by heterosexual HIV transmission, has shown that the most eff
Am J Public Health. 1990 Apr;80(4):463-4. Unique Identifier : AIDSLINE MED/90196424
Modesitt SK; Hulman S; Fleming D; Office of Health Status Monitoring, Oregon Health Division,; Portland 97201.
We searched for unreported AIDS cases in Oregon through death certificate and medical record review, and enhanced infection control practitioner and physician surveillance. Fifty-six AIDS cases diagnosed between February 1, 1986 and January 31, 1987 were reported passively. Twenty-nine additional cases diagnosed durin
Am J Public Health. 1990 Apr;80(4):465-6. Unique Identifier : AIDSLINE MED/90196425
Lewis DK; Watters JK; Case P; University of California, Santa Cruz 95064.
A sample of 149 (70 White, 79 Black) male intravenous drug users with steady female sexual partners was interviewed in 1987, in treatment and street settings, about sexual practices during the previous five years. Eighty-three percent had multiple partners, 15 percent reported male sexual contact, 38 percent reported
Am J Public Health. 1990 Apr;80(4):467-8. Unique Identifier : AIDSLINE MED/90196426
Gerbert B; Maguire BT; Coates TJ; Division of Behavioral Sciences, University of California-San; Francisco, School of Dentistry.
We conducted a nationwide telephone survey of a random sample of United States adults in summer 1988 (n = 2000, response rate = 75 percent) to find out if physicians were providing education and counseling to the public about AIDS and AIDS prevention. Within the previous five years, 94
Ann Ophthalmol. 1990 Feb;22(2):47-51. Unique Identifier : AIDSLINE MED/90196892
Cohen JI; Saragas SJ; Beth Israel Hospital, Boston, MA.
A 27-year-old man with acquired immunodeficiency syndrome [AIDS] had endophthalmitis OS four years after a trabeculectomy was done. The patient had a history of disseminated infection with Mycobacterium avium. Examination showed an intact filtering bleb with inflammation and hypopyon formation in the anterior chamber
Ann Neurol. 1990 Feb;27(2):149-56. Unique Identifier : AIDSLINE MED/90197130
Jacobson S; Gupta A; Mattson D; Mingioli E; McFarlin DE; Neuroimmunology Branch, National Institutes of Health, Bethesda,; MD 20892.
Tropical spastic paraparesis (TSP) and other chronic-progressive myelopathies have been clearly associated with increased serum and cerebrospinal fluid antibody titers to human T-lymphotropic virus type I (HTLV-I). However, little is known about the cellular immune function in TSP. In the present study, activated T ly
The purpose of this study was to describe nurses concerns, opinions, and precautions related to nursing patients infected with the human immunodeficiency virus (HIV). Of special interest was a comparison of responses by nurses who reported exposure to the HIV through broken skin or mucous membranes with the responses
ANNA J. 1990 Feb;17(1):13-8, 28. Unique Identifier : AIDSLINE MED/90197305
Scherting DG; Butera E
Hemodialysis of HIV-positive patients poses a new challenge to dialysis facilities. Organizations need to address treatment options, staffing issues, and occupational risks as programs for treatment of these individuals are developed. This article presents an overview of these concerns and one facility s experience.
ANNA J. 1990 Feb;17(1):21-8, 38. Unique Identifier : AIDSLINE MED/90197306
Schoenfeld P
The AIDS epidemic is growing worldwide, and projections for the next decade indicate that over 6 million people will develop clinical AIDS, an increase of 10-30 times the number that has been reported to date. AIDS is spreading rapidly among intravenous drug abusers, which is the risk group that is at highest risk for
ANNA J. 1990 Feb;17(1):68-70, 75. Unique Identifier : AIDSLINE MED/90197311
Collins D; Passariello B
As nurses, our belief is that not enough is known regarding AIDS or the HIV virus that causes it and because of this, concern among health care workers is justified. Prompted by this concern, we developed a protocol that we think will help improve staff safety while maintaining quality patient care. We are sharing our
Sprecher E; Becker Y; Department of Molecular Virology, Faculty of Medicine, Hebrew; University, Jerusalem, Israel.
Macrophages have been shown to play a determining role in the immune defense against herpes simplex virus-1 (HIV-1) intraperitoneal infection in the mouse. In the present study, the effect of HSV-1 infection on interleukin-1 alpha and beta gene transcription in peritoneal exudate cells was investigated. HSV-1 infectio
Dtsch Med Wochenschr. 1990 Feb 23;115(8):295-9. Unique Identifier : AIDSLINE MED/90168680
Gross M; Permanetter W; Heinrich B; Medizinische Poliklinik, Universitat Munchen.
One year after the diagnosis of HIV infection, a 34-year-old man developed marked but painless swelling of the left parotid of uncertain cause. The swelling completely regressed under 60Co gamma radiation. Subsequently subfebrile temperatures were noted, together with nausea and back pain. Hepatomegaly with signs of b
Gen Hosp Psychiatry. 1990 Mar;12(2):98-123. Unique Identifier : AIDSLINE MED/90169495
Cohen MA; New York Medical College, Metropolitan Hospital Center, New York.
The human immunodeficiency virus (HIV) epidemic has created a multidimensional crisis that is challenging the health care system. Individuals with or without risk behaviors have anxieties about acquired immunodeficiency syndrome (AIDS) and need support and counseling. Once symptoms of HIV infection develop, crisis int
J Med Genet. 1990 Jan;27(1):2-7. Unique Identifier : AIDSLINE MED/90172381
Lynch JR; Brown JM; Nuffield Department of Clinical Medicine, John Radcliffe; Hospital, Headington, Oxford.
The polymerase chain reaction has undergone rapid improvement since its initial development, such that the technique currently permits rapid, accurate, predictive tests to be made in the field of prenatal diagnosis and has greatly aided forensic medicine. It is anticipated that the polymerase chain reaction will also
JAMA. 1990 Mar 16;263(11):1497-501. Unique Identifier : AIDSLINE MED/90172481
Lemp GF; Payne SF; Rutherford GW; Hessol NA; Winkelstein W Jr; Wiley JA; Moss AR; Chaisson RE; Chen RT; Feigal DW Jr; et al; AIDS Office, Department of Public Health, City and County of San; Francisco, Calif 94102.
To develop a model for predicting acquired immunodeficiency syndrome (AIDS) morbidity in San Francisco, Calif, through June 1993, we combined annual human immunodeficiency virus seroconversion rates for homosexual and bisexual men and for heterosexual intravenous drug users with estimates of the cumulative proportion
Rickard KA; Haematology Department, Royal Prince Alfred Hospital, Sydney,; N.S.W., Australia.
The impact of HIV infection on health care delivery in haemophilia has been enormous and epoch making. Essential modifications and developments in blood product preparation have led to a shortage of FVIII concentrates and an increased cost to the consumer of the final product. The complexity and extent of the clinical
Shapiro IM; Meier C; Vlach V; McDonald TL; Wigzell H; Stevenson M; Department of Immunology, Karolinska Institute, Stockholm,; Sweden.
The human immunodeficiency virus type I (HIV-1) possesses powerful regulatory elements that control the rate of replication of HIV-1 and subsequent processing of HIV-1 genes. We have used this regulatory mechanism to drive expression of foreign genes inserted in retrovirus vectors. This approach was used to express th
Mangos JA; Doran T; Aranda-Naranjo B; Rodriguez-Escobar Y; Scott A; South Texas Children's AIDS Center, Department of Pediatrics,; University of Texas Health Science Center, San Antonio; 78284-7802.
The Centers for Disease Control reported that 109,167 cases of AIDS had been diagnosed since 1981 and that approximately 40,000 persons were living with AIDS at the time of this writing. These numbers, however, are the tip of an iceberg that consists of approximately 1.5 million Americans who are infected by the human
Wien Klin Wochenschr. 1990 Jan 19;102(2):36-45. Unique Identifier : AIDSLINE MED/90177308
Zielinski C; II. Medizinische Universitatsklinik, Wien.
An overview has been attempted of the internal complications, including infections, malignancies and other HIV-associated diseases, in patients with the acquired immune deficiency syndrome (AIDS) and a comparison made between international data and our own experience in Austria . M
Since the earliest reports of what was later termed the acquired immune deficiency syndrome (AIDS) appeared in 1980/81, with the recognition of opportunistic infections and Kaposi s sarcoma in homosexual men and i.v. drug abusers, more than 60% of AIDS patients develop pulmonary manifestations at some time in the cour
The central nervous system of nearly every HIV-positive patient becomes affected by the AIDS virus itself or by one of the associated diseases during the course of the illness. Early diagnosis of lesions which demand therapeutic consequences is of the most importance concerning prolongation of life and improvement in
Wien Klin Wochenschr. 1990 Jan 19;102(2):58-62. Unique Identifier : AIDSLINE MED/90177312
Hutterer J; Osterreichische AIDS-Hilfe, Wien.
The Austrian AIDS Foundation was founded in 1985 to satisfy the urgent needs of HIV-infected persons and those at increased risk of HIV infection, where such aid could not be met by existing medical institutions. Seven counselling centres with more than 100 members of staff provide services all over Austria. On the on
Ann Emerg Med. 1990 Mar;19(3):225-32. Unique Identifier : AIDSLINE MED/90178762
Quinn TC; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, Maryland.
During the past decade, AIDS has become a global health problem with 182,000 cases reported from 152 countries. It is estimated that nearly five to ten million people are infected worldwide with the etiologic agent of AIDS, human immunodeficiency virus type 1 (HIV-1). With a mean incubation period from time of infecti
Ann Emerg Med. 1990 Mar;19(3):233-41. Unique Identifier : AIDSLINE MED/90178763
Terwilliger EF; Sodroski JG; Haseltine WA; Division of Human Retrovirology, Dana-Farber Cancer Institute,; Boston, Massachusetts 02115.
Human immunodeficiency virus type 1 (HIV-1), a retrovirus, is the etiologic agent of AIDS. Like all retroviruses, the viral genes are carried in the viral particle in the form of single-stranded RNA. Once inside a susceptible host cell, this RNA template is reverse-transcribed by virally supplied enzyme functions into
Pimentel E; Centro Nacional de Genetica, Universidad Central de Venezuela,; Caracas.
The colony-stimulating factors (CSFs) are hematopoietic growth factors (HGFs) involved in regulating the formation of nonlymphoid blood cells. A brief review of the different types of CSFs and their biological properties is presented. The current nomenclature of CSFs and other HGFs is confused by the use of terms and
A 99-amino acid protein having the deduced sequence of the protease from human immunodeficiency virus type 2 (HIV-2) was synthesized by the solid phase method and tested for specificity. The folded peptide catalyzes specific processing of a recombinant 43-kDa GAG precursor protein (F-16) of HIV-1. Although the proteas
Aviat Space Environ Med. 1990 Feb;61(2):165-8. Unique Identifier : AIDSLINE MED/90179655
Clark JB; Neurology Department, Naval Aerospace Medical Institute,; Pensacola, FL 32508-5600.
This article reviews the available medical data that form the basis for the U.S. Navy s policy on aeromedical disposition of Human Immunodeficiency Virus (HIV) seropositive flyers. Following a brief review of military HIV antibody testing and clinical evaluation, this article addresses the main issue in the Navy s aer
Blood. 1990 Mar 15;75(6):1215-9. Unique Identifier : AIDSLINE MED/90181605
Hammer SM; Gillis JM; Pinkston P; Rose RM; Department of Medicine, New England Deaconess Hospital, Boston,; MA 02215.
The alveolar macrophage (AM), as a representative human tissue macrophage, was used in an in vitro system to examine the anti-human immunodeficiency virus type-1 (HIV-1) activity of zidovudine ( AZT ) and granulocyte-macrophage colony-stimulating factor
Can Med Assoc J. 1990 Mar 15;142(6):557-62. Unique Identifier : AIDSLINE MED/90182459
Rock GA; Tricklebank GW; Kasaboski CA; Department of Medicine, University of Ottawa.
Since 1982 the Canadian Apheresis Study Group (CASG) has collected data on plasma exchange activities in Canada . In 1987, 5907 such procedures were carried out on 700 patients for more than 22 different diseases; this represented an increase of 28% over the figure for 1982. A shift
Dan Med Bull. 1990 Feb;37(1):86-9. Unique Identifier : AIDSLINE MED/90183490
Orholm M; Lundgren JD; Nielsen TL; Iversen J; Department of Infectious Diseases, Hvidovre Hospital, Copenhagen.
During a six-month period, 40 consecutive fiberoptic bronchoscopic procedures including bronchoalveolar lavage, bronchial brushing and forceps biopsy were performed in local anaesthesia on 34 HIV-infected males presenting symptoms compatible with Pneumocystis carinii pneumonia. In 23 examinations, P. carinii was found
EMBO J. 1990 Mar;9(3):965-70. Unique Identifier : AIDSLINE MED/90183998
Salfeld J; Gottlinger HG; Sia RA; Park RE; Sodroski JG; Haseltine WA; Dana-Farber Cancer Institute, Department of Pathology, Harvard; Medical School, Boston, MA 02115.
A 26 kd protein reactive with antiserum to the transactivator tat of the Human Immunodeficiency Virus Type 1 (HIV-1) has been detected in virus producing cells. The 26 kd protein is shown to be a tripartite fusion protein including coding sequences of the tat, envelope (env) and regulator of virion expression (rev) ge
Miller RF; Department of Medicine, Jules Thorn Institute of Clinical; Science, University College and Middlesex School of Medicine,; Middlesex Hospital, London, UK.
Over the last decade the acquired immunodeficiency syndrome (AIDS) has become one of the leading causes of morbidity and mortality both in Europe and the United States . The disease is due to infection by the human immunodeficiency virus (HIV), which results in progressive loss of cellu
Sonnichsen N; Kolzsch J; Klinik und Poliklinik fur Hautkrankheiten, Bereichs Medizin; (Charite), Humboldt-Universitat zu Berlin.
The HIV-infection represents simultaneously a new and important problem. Multiple changes appear on skin and mucous membranes in all stages of the infection. These changes have an essential diagnostic significance especially in the early phase of the infection. The most important changes become represented systematica
The authors report a case of tuberculous pancreatitis in a 29 year old Zairan man. Serum antibodies against HIV were positive. T-lymphocyte analysis revealed 18/mm3 OKT4 with an OKT4/OKT8 ratio of 0.43. The initial examination suggested severe acute pancreatitis. Only the postmortem histopathological analysis revealed
Allergy Proc. 1990 Jan-Feb;11(1):15-8. Unique Identifier : AIDSLINE MED/90185172
Kaplan AP; Department of Medicine, SUNY, Stony Brook 11794.
It appears that when hives are fleeting, as is seen in physically induced hives, they are caused by a rapid burst of local mast cell degranulation. There is no tissue infiltration with cells, no late-phase component to the reaction, and therapy is dependent on antihistaminics or mast cell stabilizing agents. The nonsu
Hosp Community Psychiatry. 1990 Mar;41(3):290-300. Unique Identifier : AIDSLINE MED/90185611
Dickson LR; Ranseen JD; Department of Psychiatry, University of Kentucky College of; Medicine, Lexington 40536.
The authors review recent literature on four medical conditions that constitute important examples of organic mental disorders: AIDS dementia complex, cocaine abuse, cerebrovascular accident, and traumatic brain injury. These disorders are of particular interest because they are fr
Kinghorn GR; Department of Genitourinary Medicine, Royal Hallamshire Hospital,; Sheffield, UK.
The arrival of AIDS/HIV infection in the UK has conferred a new significance upon genitourinary medicine which is necessarily involved in all aspects of patient care, surveillance and prevention. HIV should now be considered a relevant issue for discussion with all presenting patients who are at-risk of contracting an
Alvarez R; Adan A; Martinez JA; Casale A; Miro JM; Infectious Diseases Unit, Hospital Clinic i Provincial,; Barcelona, Spain.
A case of haematogenous Serratia marcescens endophthalmitis in an HIV-infected intravenous drug addict is described. The patient was admitted with fever, ocular pain and visual loss in the right eye following an i.v. injection of pulverized buprenorphine. A vitreous humor culture grew S. marcescens. The patient was tr
Yust I; Vardinon N; Skornick Y; Zakuth V; Hasner A; Shinitzky M; Goldman Memorial Clinical Immunology Laboratory, Ichilov; Hospital, Tel Aviv Medical Center, Israel.
Sixteen patients seropositive for human immunodeficiency virus (HIV) at different stages participated in an open trial using the lipid mixture AL-721. Seven patients were antigen negative and asymptomatic and the other nine antigen positive, three of whom were virtually asymptomatic. AL-721 was given per os once a day
Karpatkin S; New York University Medical School, Department of Medicine, New; York.
Immunologic thrombocytopenia has recently been described in HIV-1 seropositive patients: homosexuals, narcotic addicts, hemophiliacs, and heterosexual partners of HIV-1 infected patients. All patients have markedly elevated platelet-bound IgG and C3C4 as well as circulating immune complexes. The immune complexes of ho
Markowicz S; Engleman EG; Department of Pathology, Stanford University School of Medicine,; California 94305.
Interest in human dendritic cells (DC) has been heightened recently by the discovery that this cell type is a primary target of the human immunodeficiency virus, the causative agent of AIDS. DC are bone marrow-derived cells with an extraordinarily potent ability to promote the immunological activity of T lymphocytes.
Cockerell CJ; LeBoit PE; Department of Dermatology, University of Texas Southwestern; Medical Center, Dallas 75235-9072.
Bacillary angiomatosis (also called epithelioid angiomatosis) is a newly recognized disease most often characterized by a cutaneous infection with reddish papules of vascular origin. It is caused by a weakly reactive gram-negative bacillus, which can be easily demonstrated in tissue sections with the Warthin-Starry st
Jimenez-Acosta F; Pardo RJ; Cohen RJ; Gould EW; Penneys NS; Department of Dermatology and Cutaneous Surgery, University of; Miami School of Medicine, FL 33101.
Sacks HS; Rose DN; Clinical Trials Unit, Mount Sinai School of Medicine, City; University of New York, New York.
OBJECTIVE: To perform a decision analysis to determine the thresholds of safety and effectiveness that would justify short-term zidovudine ( AZT ) administration for persons with accidental percutaneous exposure to HIV-positive blood. DESIGN: Published
Biondi M; Kotzalidis GD; Third Psychiatric Clinic, University of Rome, La Sapienza, Italy.
Studies in human psychoneuroimmunology began around 1919, but a systematic approach wasn t used until the work of Solomon in the 1960s. Recently, the new specialty has achieved relative independence due to considerable data acquisition. Stress research has revealed relationships between neuroendocrine and immune chang
Ranki A; Jarvinen K; Valle SL; Nurmilaakso P; Krohn K; Department of Dermatology, Helsinki University Central Hospital,; Finland.
Antibodies to the human immunodeficiency virus (HIV) regulatory gene nef (negative factor) product are claimed to be characteristic of early and latent HIV infection. We looked for anti-nef antibodies in individuals infected with HIV or at risk for HIV, in blood donors, and in patients with diverse dermatological diso
Anderson RM; Gupta S; Ng W; Parasite Epidemiology Research Group, Imperial College, London; University, U.K.
The paper provides a brief review of the significance of heterogeneity in sexual behaviour to the transmission dynamics of HIV and the spread of AIDS. It addresses the formulation of mathematical models to encapsulate variability in the rate of sexual partner change, the structure of networks of sexual partner contact
Voll R; Aepinus C; Krapf F; Herrmann M; Kalden JR; Fleckenstein B; Institut fur Klinische und Molekulare Virologie, Universitat; Erlangen-Nurnberg, Federal Republic of Germany.
The rev (art/trs) protein of human immunodeficiency virus type 1 (HIV-1), a phosphoprotein of 20 K apparent molecular weight, is essential to target the mRNA for virion polypeptides into the cytoplasm. The rev protein was expressed in Escherichia coli as a beta-galactosidase fusion protein with a cleavage site for pro
N Y State J Med. 1990 Mar;90(3):155-7. Unique Identifier : AIDSLINE MED/90191367
Ravalli S; Garcia RL; Vincent RA; Shein R; Department of Pathology, Beth Israel Medical Center, Mount Sinai; School of Medicine, City University of New York 10003.
King FJ; Cole MD; Department of Biology, Princeton University, NJ.
The c-fgr gene is a member of the tyrosine kinase family of proto-oncogenes and is expressed exclusively in hemopoietic cells. We found that c-fgr was expressed at high levels in a limited subset of murine monocyte/macrophage tumors that were induced by the c-myc oncogene, in cells representing late stages of monocyte
Kwok S; Kellogg DE; McKinney N; Spasic D; Goda L; Levenson C; Sninsky JJ; Department of Infectious Diseases, Cetus Corporation, Emeryville,; CA.
We investigated the effects of various primer-template mismatches on DNA amplification of an HIV-1 gag region by the polymerase chain reaction (PCR). Single internal mismatches had no significant effect on PCR product yield while those at the 3 -terminal base had varied effects. A:G, G:A, and C:C mismatches reduced ov
Joshi VV; Oleske JM; Connor EM; Department of Pathology, Children's Hospital of New Jersey, New; Jersey Medical School, Newark 07107.
The lesions observed in biopsy and autopsy material from children with the acquired immunodeficiency syndrome (AIDS) can be divided into three pathogenetic categories: primary lesions related to infection by human immunodeficiency virus (HIV) (e.g., lymphoreticular system and brain); lesions due to the sequelae of HIV
Luburich P; Bru C; Ayuso MC; Azon A; Condom E; Department of Radiology, Hospital Clinic i Provincial, Barcelona,; Spain.
Abdominal ultrasonography (US) and computed tomography (CT) were performed in two patients with acquired immunodeficiency syndrome (AIDS) and necropsy-proved hepatic Kaposi sarcoma. At US, small (5-12-mm) hyperechoic nodules and dense periportal bands were seen in the liver. These lesions appeared hypoattenuated on ba
Science. 1990 Mar 9;247(4947):1216-9. Unique Identifier : AIDSLINE MED/90193681
Roy S; Katze MG; Parkin NT; Edery I; Hovanessian AG; Sonenberg N; Department of Biochemistry, McGill University, Montreal, Canada.
The tat-responsive region (TAR) of the human immunodeficiency virus-1 (HIV-1) exhibits a trans-inhibitory effect on translation in vitro by activating the interferon-induced 68-kilodalton protein kinase (p68 kinase). Productive infection by HIV-1 was shown to result in a significant decrease in the amount of cellular
During autumn- and winter epidemics respiratory syncytial (RS) virus accounts for the majority of respiratory infections in infants and young children. In case of an acute lower respiratory tract infection, RS virus can induce serious symptoms. These are age-dependent. The most important symptoms in babies and toddler
Am J Dermatopathol. 1990 Feb;12(1):63-6. Unique Identifier : AIDSLINE MED/90196522
Pierard GE; Pierard-Franchimont C; Estrada JA; Rurangirwa A; Dosal FL; Department of Dermatopathology, University of Liege, Belgium.
We report a new case of mixed infection occurring at the same site of the skin in a human immune deficiency virus-positive patient. Hyperkeratotic and crusted erosions contained fusospirochetal organisms, Cryptococcus neoformans, and another unidentified fungus.
Ilyinskii PO; Morozov VA; Ilyin KV; All-Union Cancer Research Center, Moscow, U.S.S.R.
The study of the gag-coded glycosylated polyprotein (gPr78gag) from type D retrovirus-producing cells is reported. It is shown that glycosylation inhibitors tunicamycin and 2-deoxy-D-glucose are blocking the synthesis of gPr78gag. This demonstrates that gPr78gag is a N-glycan. The protein part of gPr78gag is supposedl
McChesney M; Tanneau F; Regnault A; Sansonetti P; Montagnier L; Kieny MP; Riviere Y; Departement de Medecine, Institut Pasteur, Paris, France.
A heterogenous population of envelope glycoprotein-specific cytotoxic effector cells are found in the peripheral blood of individuals infected with HIV-1, and in many cases env-specific lysis is not restricted by MHC molecules and is not blocked by antibody to CD3 (Riviere, Y. et al., J. Virol. 1989, 63:2270). In orde
Gallo P; Piccinno MG; De Rossi A; Pagni S; Amadori A; Chieco-Bianchi L; Tavolato B; Institute of Neurology, Interuniversity Center for Research on; Cancer, University of Padova, Italy.
The presence of immunoglobulin (Ig) free light chains (FLC) was investigated in the cerebrospinal fluid (CSF) of human immunodeficiency virus type 1 (HIV-1)-infected patients. Intrathecal synthesis of FLC was demonstrated in 80% of the patients, even in the absence of oligoclonal Ig. The FLC patterns were characterize
Hibberd PL; Rubin RH; Harvard Medical School, Boston, Massachusetts.
An ever-increasing population of immunocompromised individuals, including not only the burgeoning AIDS population but also those patients whose host defenses have been damaged by a wide variety of diseases and their therapies, requires prophylaxis against infectious diseases. Existing vaccines can provide some benefit
J Med Chem. 1990 Mar;33(3):978-85. Unique Identifier : AIDSLINE MED/90172375
Marquez VE; Tseng CK; Mitsuya H; Aoki S; Kelley JA; Ford H Jr; Roth JS; Broder S; Johns DG; Driscoll JS; Laboratory of Medicinal Chemistry, National Cancer Institute,; NIH, Bethesda, Maryland 20892.
2 ,3 -Dideoxy purine nucleosides have anti-HIV activity in vitro and the inosine analogue is being clinically evaluated. The instability of these compounds toward acidic conditions complicates oral administration. The effect of the addition of a fluorine atom to the 2 -position was investigated by preparing the fluori
Mil Med. 1990 Jan;155(1):23-6. Unique Identifier : AIDSLINE MED/90174410
Perciballi JA; Etienne HB; Ghosh BC; Department of Surgery, Uniformed Services University of the; Health Sciences, Bethesda.
Kaposi s Sarcoma is a rare disease. Gastrointestinal involvement of Kaposi s is very unusual. With the increasing incidences of Acquired Immune Deficiency Syndrome (AIDS) it has become more common in both civilian and military practice. The practicing physician should be aware of gastrointestinal symptoms of Kaposi s
Mil Med. 1990 Jan;155(1):27-30. Unique Identifier : AIDSLINE MED/90174411
Daniell FD; Skelly RR; Friedman S; Slifer D; Anderson G; McLean S; Johnson L; Occupational Health and Preventive Medicine Department, Naval; Hospital, Bethesda, Maryland.
A basic Public Health approach to the Human Immunodeficiency Virus (HIV) epidemic has been considered by many to be the most appropriate initial strategy against the spread of this infection. Comprehensive Preventive Medicine services were implemented at Naval Hospital Bethesda, which utilized a sexually transmitted d
Mil Med. 1990 Feb;155(2):76-80. Unique Identifier : AIDSLINE MED/90174429
Pace J; Brown GR; Rundell JR; Paolucci S; Drexler K; McManis S; Department of Psychiatry (SGHMS), Wilford Hall Medical Center,; Lackland AFB, TX 78236.
Ninety-five randomly selected human immunodeficiency virus (HIV)-seropositive Air Force personnel were psychiatrically examined during a routine medical evaluation. Of the 95, 95% did not have acquired immunodeficiency syndrome and were largely asymptomatic; 61.1% had clinical axis I diagnoses, which included simple p
Mod Pathol. 1990 Jan;3(1):54-60. Unique Identifier : AIDSLINE MED/90175342
Westermann CD; Hurtubise PE; Linnemann CC; Swerdlow SH; Department of Pathology and Laboratory Medicine, University of; Cincinnati College of Medicine, Ohio.
While cell suspension immunophenotypic studies are widely used as an aid in the diagnosis and classification of lymphomas and leukemias, much less attention has been directed toward interpretation of the results in reactive lymphoid proliferations. Cell suspension immunophenotypic data were therefore analyzed for 119
Public Health Rep. 1990 Jan-Feb;105(1):1-12. Unique Identifier : AIDSLINE MED/90175810
Hellinger FJ; Division of Extramural Research, National Center for Health; Services Research, Rockville, MD.
Data on the number of AIDS cases reported to the Centers for Disease Control (CDC) from January 1984 to June 1989 are used to predict the number of AIDS cases that will be diagnosed during the years 1989 through 1993. Using quadratic and linear models with the most recent data, it is projected that about 44,000 cases
Brandwein M; Choi HS; Strauchen J; Stoler M; Jagirdar J; Department of Pathology, Mount Sinai School of Medicine, New; York, NY.
We report 5 patients with AIDS who had an unusual spindle cell proliferation in the lymph nodes and skin caused by nontuberculous mycobacteriosis. The spindle cell proliferation in these tissues may mimic a spindle cell neoplasm and pose a diagnostic problem if an infectious aetiology is not suspected. The fibroblast-
BMJ. 1990 Jan 27;300(6719):219-23. Unique Identifier : AIDSLINE MED/90181687
Skidmore CA; Robertson JR; Robertson AA; Elton RA; Edinburgh Drug Addiction Study, Muirhouse Medical Group,; Edinburgh.
OBJECTIVE--To follow up known intravenous drug users to determine current health state and drug use, compare characteristics with those of recent drug users, and examine HIV exposure and serostate. DESIGN--Subjects were identified from conventional general practice records and recruited from 1980 to the end of 1985; t
BMJ. 1990 Jan 27;300(6719):241-3. Unique Identifier : AIDSLINE MED/90181696
Smits A; Mansfield S; Singh S; St. Mary's Hospital, London.
To complement the role of primary care teams working with patients with HIV disease and AIDS within greater London and to ease the load on the special hospital units a home support team was developed. It comprises six specialist nurses, a general practitioner trained medical officer, and a receptionist and is funded f
BMJ. 1990 Feb 3;300(6720):300-4. Unique Identifier : AIDSLINE MED/90181722
Cruickshank JK; Richardson JH; Morgan OS; Porter J; Klenerman P; Knight J; Newell AL; Rudge P; Dalgleish AG; Department of Medicine, Northwick Park Hospital, Harrow.
OBJECTIVE--To compare the prevalence of antibody to and proviral DNA of the retrovirus HTLV-I in relatives of 11 British patients with tropical spastic paraparesis who had migrated from Jamaica before they developed symptoms, and to examine factors possibly related to transmission
Cell. 1990 Mar 9;60(5):747-54. Unique Identifier : AIDSLINE MED/90182664
Camerini D; Seed B; Department of Genetics, Harvard Medical School, Boston,; Massachusetts.
HIV infection of chimpanzees results in a chronic viremia unaccompanied by the ultimately fatal immunodeficiency that marks HIV infection in man. We show here that expression of HIV envelope proteins allows syncytium formation between cells expressing human but not chimpanzee or macaque CD4. We find that the CD4 seque
Arora PK; Fride E; Petitto J; Waggie K; Skolnick P; Laboratory of Neuroscience, NIDDK, National Institutes of Health,; Bethesda, Maryland 20892.
The high incidence of human immunodeficiency virus (HIV) seropositivity among drug abusers prompted us to examine in an animal model the effects of morphine on aspects of the immune system that may be specifically related to HIV infection. We now report a robust, sustained elevation in the ratio of CD4+/CD8+ cells in
FEBS Lett. 1990 Feb 26;261(2):241-4. Unique Identifier : AIDSLINE MED/90184453
Goldblum A; Department of Pharmaceutical Chemistry, School of Pharmacy,; Hebrew University of Jerusalem, Israel.
The active sites of 3 types of aspartic proteases are modeled, based on crystallographic coordinates of endothiapepsin and of a model of HIV-1 protease. The enthalpies of deprotonation from neutral to mono-anion and to dianion are calculated with semiempirical minimal neglect of differential overlap, hydrogen bonding
Spielberg FA; Kabeya CM; Quinn TC; Ryder RW; Kifuani NK; Harris J; Bender TR; Heyward WL; Tam MR; Auditore-Hargreaves K; Program for Appropriate Technology in Health, Seattle, Washington; 98109.
Recent studies have shown that rapid, instrument-free assays for the detection of antibody to human immunodeficiency virus (HIV) can be as sensitive and specific as enzyme-linked immunosorbent assay (ELISA) for screening of donated blood in developing countries. Currently, however, specimens which test positive on a s
Le Gales C; Moatti JP; INSERM Unite 240, Evaluation des risques et des actions de; prevention, Fontenay-aux-Roses.
Spontaneous diffusion of HIV screening at the occasion of pregnancy has been especially rapid in France . In April-May 1988, 45% of general practitioners systematically prescribed HIV screening during premarital or prenatal consultations. Experimentation of systematic prenatal HIV s
Mil Med. 1990 Mar;155(3):98-104. Unique Identifier : AIDSLINE MED/90191191
Rothberg JM; Bain MW; Boggiano W; Cline WR; Grace WC; Holloway HC; Rock NL; Division of Neuropsychiatry, Walter Reed Army Institute of; Research, Washington, DC 20307-5100.
Following mandatory military-wide testing for the human immunodeficiency virus (HIV), Army medical facilities have gained extensive experience with HIV-positive persons who undergo special stresses as a result of their affiliation with the military. The consequences of evacuation to medical centers for evaluation of H
Hughes RG; School of Health Administration and Policy, College of Business,; Arizona State University.
Arizona is a second wave state, ranking twenty-first among states in a number of reported AIDS cases. Interviews with 50 administrators and providers were used to determine how Arizona s Medicaid program, the Arizona Health Care Cost Containment System (AHCCCS), has responded to the AIDS epidemic. AHCCCS is a unique M
Science. 1990 Mar 9;247(4947):1222-5. Unique Identifier : AIDSLINE MED/90193683
Sarver N; Cantin EM; Chang PS; Zaia JA; Ladne PA; Stephens DA; Rossi JJ; Division of Research and Development Program, National Institute; of Allergy and Infectious Diseases, Bethesda, MD 20892.
Certain RNA molecules, called ribozymes, possess enzymatic, self-cleaving activity. The cleavage reaction is catalytic and no energy source is required. Ribozymes of the hammerhead motif were identified in plant RNA pathogens. These ribozymes possess unique secondary (and possibly tertiary) structures critical for the
Jessurun J; Romo-Garcia J; Lopez-Denis O; Olvera-Rabiela JE; Unidad de Patologia, Hospital General de Mexico, D.F. 06726.
A case of crusted (Norwegian) scabies in a patient with the acquired immunodeficiency syndrome (AIDS) is described and seven previous reports of this association are reviewed. Injury to epidermal Langerhans cells by the human immunodeficiency virus or cytotoxic cells may explain the appearance of this unusual form of
J Immunol. 1990 Mar 1;144(5):1696-704. Unique Identifier : AIDSLINE MED/90171560
Pantaleo G; Koenig S; Baseler M; Lane HC; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892.
This study examines the potential mechanism(s) responsible for the defective clonability of CD8+ T lymphocytes in patients with AIDS. By the combined use of one- and two-color fluorescence cytofluorometry we have shown an increase in the number of circulating DR+ cells due to the expression of DR on a relatively large
Bridges AJ; Norback D; Fisch P; England D; Sondel P; Department of Medicine, University of Wisconsin, Madison 53792.
A 36-year-old man presented with an acute immune-mediated illness characterized by leukocytoclastic vasculitis and polyarthritis. Evaluation of the synovial fluid, bone marrow, and peripheral blood revealed large numbers of abnormal lymphoid cells labeling a 4B4-positive, CD4-positive,
Khayat D; Soubrane C; Andrieu JM; Visonneau S; Eme D; Tourani JM; Beldjord K; Weil M; Fernandez E; Jacquillat C; Laboratory of the Department of Medical Oncology, Salpetriere; Hospital, Paris, France.
The modulation of soluble CD16 titers in human immunodeficiency virus (HIV)-infected patients serum, with an initial increase in Centers for Disease Control (CDC) clinical stage II and III patients followed by a dramatic drop in patients with AIDS (CDC clinical stage IV), is reported. These changes are statistically
Poland GA; Love KR; Hughes CE; Section of General Internal Medicine, Mayo Clinic and Foundation,; Rochester, Minnesota.
Physicians should develop the habit of considering, during initial routine and subsequent examinations of persons coming under their primary care, whether a vaccine is needed to establish or maintain universally recommend immunity. Furthermore, the physician should identify specific circumstances that call for special
We retrospectively studied the clinical, serological, bacteriological and histopathological data obtained in 6 HIV seropositive patients seen in our department from 1986 to 1989 for secondary syphilis. The clinical presentation was atypical in 4 of the 6 patients, with 2 palmoplantar keratodermas and 2 ulcerative syph
Can J Vet Res. 1990 Jan;54(1):42-8. Unique Identifier : AIDSLINE MED/90167575
Narayan O; Division of Comparative Medicine, Johns Hopkins University School; of Medicine, Baltimore, Maryland 21205.
Lentiviruses are species-specific, exogenously transmitted retroviruses that have a unique ability to replicate continuously but at a restricted rate in host tissues. This property is thought to be related to the retroviral nature of the replication process (RNA to DNA to RNA) and to the ability of the viruses to do t
Cancer. 1990 Mar 15;65(6):1345-9. Unique Identifier : AIDSLINE MED/90167597
Mittal K; Neri A; Feiner H; Schinella R; Alfonso F; Department of Pathology, New York University School of Medicine,; Bellevue Hospital, NY 10016.
A case of lymphomatoid granulomatosis of lung that occurred in a patient with the acquired immunodeficiency syndrome (AIDS) was studied by light microscope, electron microscope, cell surface markers, and Southern blot test. Clonal selection of two clones of B-cells was seen. Two clones were infected with Epstein-Barr
Merenich JA; McDermott MT; Asp AA; Harrison SM; Kidd GS; Department of Medicine, Fitzsimons Army Medical Center, Aurora,; Colorado 80045-5001.
Adrenal, gonadal, and thyroid function were assessed in 40 asymptomatic subjects in whom infection with the human immunodeficiency virus (HIV) had recently been documented. None of the patients had historical or clinical evidence of endocrine dysfunction. Their mean serum hormone levels were also within the expected r
Villette JM; Bourin P; Doinel C; Mansour I; Fiet J; Boudou P; Dreux C; Roue R; Debord M; Levi F; Unite d'Hormonologie, Laboratoire de Biochimie, Hopital; Saint-Louis, Paris, France.
Alterations in the circadian time structure of the secretion of several hormones were investigated in 13 male patients infected with human immunodeficiency virus (HIV). Seven were asymptomatic (classified CDC II, according to the criteria of the Atlanta Centers for Disease Control), and 6 had acquired immunodeficiency
Oberfield SE; Kairam R; Bakshi S; Bamji M; Bhushan V; Mayes D; Levine LS; Department of Pediatrics, St. Luke's-Roosevelt Hospital Center,; New York, New York 10025.
To evaluate whether frank or subtle disorders of adrenal steroidogenesis exist in human immunodeficiency virus (HIV)-infected children, the adrenal steroid response to an iv bolus of ACTH-(1-24) (0.25 mg Cortrosyn) was determined. Ten children (six males and four females, aged 7 months to 7.5 yr) were studied. Five un
Lazzarotto T; Guan MX; Furlini G; Re MC; Ripalti A; Landini MP; La Placa M; Institute of Microbiology, University of Bologna, St. Orsola; General Hospital, Italy.
Acute or recent Cytomegalovirus infections were serologically identified in HIV1-seropositive individuals and studied in relation to HIV1 replication as HIV1-p24 antigenemia. The results obtained indicate that active CMV infections are often observed in HIV1-ser
N Engl J Med. 1990 Mar 15;322(11):713-6. Unique Identifier : AIDSLINE MED/90174215
Jenny C; Hooton TM; Bowers A; Copass MK; Krieger JN; Hillier SL; Kiviat N; Corey L; Stamm WE; Holmes KK; Department of Pediatrics, University of Washington School of; Medicine, Seattle.
The risk of acquiring a sexually transmitted disease as a result of rape is not known, in part because it is difficult to ascertain whether infections were present before the assault or acquired during it. To investigate this question, we examined female victims of rape within 72 hours of the assault and again at leas
Bieth E; Gabus C; Darlix JL; LaboRetro, Centre de Recherches de Biochimie et de Genetique; Cellulaires du CNRS, Toulouse, France.
The genetic material of all retroviruses examined so far is an RNA dimer where two identical RNA subunits are joined at their 5 ends by a structure named dimer linkage structure (DLS). Since the precise location and structure of the DLS as well as the mechanism and role(s) of RNA dimerization remain unclear, we analy
McGuire TC; Lacy PA; O'Rourke KI; Department of Veterinary Microbiology and Pathology, College of; Veterinary Medicine, Washington State University, Pullman; 99164-7040.
Computer tomographic and histopathological findings in 55 patients who died of the complications of acquired immunodeficiency syndrome, were reviewed retrospectively. In 23 patients (42%) an increased space of the internal or external cerebral spinal fluid was diagnosed. 20 patients (36%) had focal lesions. We differe
Di Luca D; Katsafanas G; Schirmer EC; Balachandran N; Frenkel N; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, NIH, Rockville, Maryland 20852.
Human herpesvirus 6 (HHV-6) is a newly identified lymphotropic herpesvirus. We have analyzed viral and host DNA replication in peripheral blood lymphocytes infected in the absence of drugs or infected in the presence of phosphonoacetic acid (PAA) or acyclovir (ACV). The results
Ann Emerg Med. 1990 Mar;19(3):242-8. Unique Identifier : AIDSLINE MED/90178764
Kelen GD; Division of Emergency Medicine, Johns Hopkins University School; of Medicine, Baltimore, MD.
The AIDS epidemic is having an increasing impact on the practice of emergency medicine. In inner-city emergency departments, significant numbers of patients have unrecognized human immunodeficiency virus (HIV) infection. Transmission of HIV in the health care setting has been predominantly from exposure to patients i
Heifets LB; Lindholm-Levy PJ; Flory MA; National Jewish Center for Immunology and Respiratory Medicine,; Denver, CO 80206.
Minimal inhibitory and bactericidal concentrations (MICs and MBCs) of rifampin (RMP), rifabutin (RBT), rifapentine (RPT), CGP-7040, and P-DEA, were determined for 50 M. avium strains in 7H12 liquid medium radiometrically under various pH conditions. Half were isolated from patients with AIDS and the other half from pa
Ann Intern Med. 1990 Mar 15;112(6):416-22. Unique Identifier : AIDSLINE MED/90178896
Englund JA; Zimmerman ME; Swierkosz EM; Goodman JL; Scholl DR; Balfour HH Jr; University of Minnesota Health Sciences Center, Minneapolis.
STUDY OBJECTIVE: To determine the sensitivity of herpes simplex virus isolates to acyclovir and the importance of resistant isolates in hospitalized patients. DESIGN: Retrospective incidence cohort study. SETTING: All herpes simplex virus isolates cultured over 1 year from patie
Enders G; Biber M; Meyer G; Helftenbein E; Inst. f. med. Virologie u. Infektions-epidemiologie, Stuttgart,; FR Germany.
We determined IgG antibodies against Human Herpesvirus-6 (strain Uganda 1102, M. D. Griffin, London) in the indirect immunofluorescence test in sera from 1105 persons of various age groups. Of these sera 570 were retested using HHV-6 strain St. W. (Prof. Schneweis, Bonn). We could
Handzel ZT; Burstein R; Cohen J; Pecht M; Trainin N; Vonsover A; Sayer Y; Gotlieb-Stematsky T; Bentwich Z; R. Ben-Ari Institute of Clinical Immunology, Kaplan Hospital,; Rehovot, Israel.
High rates of immunologic abnormalities in asymptomatic, clinically healthy urban homosexual men have been associated with promiscuous, unprotected receptive rectal intercourse, and related to infection by the human immunodeficiency virus (HIV), Epstein-Barr virus (EBV) and cytomegalov
J Immunol. 1990 Mar 15;144(6):2173-8. Unique Identifier : AIDSLINE MED/90187858
Yoshimura N; Nakamura H; Ishikawa K; Noda Y; Honjo S; Hayami M; Department of Animal Pathology, University of Tokyo, Japan.
Studies were made on the cellular immunity of 13 African green monkeys (Cercopithecus aethiops) naturally infected with Simian T cell leukemia virus type 1 (STLV-1), closely related to human T cell leukemia virus type 1. They were classified into 3 groups: 1) progressed carrier, 2) carrier, and 3) normal control. This
Human herpesvirus-6 (HHV-6) and human immunodeficiency virus (HIV) are both tropic for CD4+ lymphocytes. To determine whether HHV-6 infection affects the susceptibility to or the course of HIV infection, HHV-6 titers were measured by an anticomplement immunofluorescence assay in serum of three groups of homosexual or
Caputo A; Sodroski JG; Haseltine WA; Division of Human Retrovirology, Dana-Farber Cancer Institute,; Boston, MA 02115.
The production and characterization of Jurkat cell lines that constitutively express functional human immune deficiency virus type 1 (HIV-1) tat protein, using a BK virus plasmid expression vector and HIV-1 tat cDNA, is described. An increased growth rate of these Jurkat-tat cell lines as compared with control cell li
Simultaneous primary infection with HIV and CMV in an 18-year-old woman led to an acute cytotoxic reaction, manifesting as pancytopenia, hepatitis, nephritis, perimyocarditis, and myositis. Within 14 days parameters indicating acute cell damage reverted to norma
Mo Med. 1990 Mar;87(3):141-4. Unique Identifier : AIDSLINE MED/90190576
Clifford DB; Department of Neurology, Washington University School of; Medicine, St. Louis, Missouri.
The neurological complications of acquired immunodeficiency syndrome (AIDS) can be severe. The author presents an overview of the most common neurological conditions HIV infected patients are susceptible to and stresses the importance of early diagnosis.
Nature. 1990 Mar 15;344(6263):257-9. Unique Identifier : AIDSLINE MED/90190844
Haigh A; Greaves R; O'Hare P; Marie Curie Research Institute, Oxted, Surrey, UK.
Induction of transcription of the immediate-early (IE) genes of herpes simplex virus (HSV) involves the assembly of a DNA-binding complex containing the cellular transcription factor Oct-1 and the virus regulatory protein Vmw65 (VP16). Complex assembly can be observed using deletion variants of Vmw65 which lack the ac
Verma RK; Ziegler DK; Kepes JJ; Department of Neurology, University of Kansas Medical Center,; Kansas City 66103.
A young homosexual man presented with slowly progressive weakness and diffuse fasciculations. Muscle biopsy was compatible with clinical diagnosis of motor neuron disease. The patient died from opportunistic infections related to acquired immunodeficiency syndrome. Autopsy revealed evidence of myelopathy, patchy fiber
Anderson VM; Greco MA; Recalde AL; Chandwani S; Church JA; Krasinski K; New York City Department of Health, Bureau of Child Health, New; York 10013.
Cytomegalovirus in children with human immunodeficiency virus (HIV) infection can result in widespread involvement of enteric ganglion cells. Intestinal ganglioneuronitis, as noted in the two infants cited, expands the spectrum of neurologic lesions in children with acquired immunodeficiency syndrome (AIDS).
Pryka RD; Novak RM; Wagner DK; Rodvold KA; Clinical Pharmacokinetics and Infectious Diseases, College of; Pharmacy, University of Toledo, OH.
Daptomycin is a new lipopeptide antibiotic for which preliminary pharmacokinetic data in adults have been limited to normal healthy volunteers and patients with renal insufficiency. We report the clinical pharmacokinetics of the first and fifth doses of iv daptomycin 150 mg (2 mg/kg) q24h in a 29-year-old man being tr
Sivit CJ; Taylor GA; Patterson K; Thompson R; Josephs SH; Department of Diagnostic Imaging and Radiology, Children's; National Medical Center, Washington, DC.
Lynch P; Cummings MJ; Roberts PL; Herriott MJ; Yates B; Stamm WE; Department of Medicine, Harboview Medical Center, University of; Washington School of Medicine, Seattle 98104.
Body substance isolation (BSI) is a system of infection precautions intended to reduce nosocomial transmission of infectious agents among patients and to reduce the risk of transmission of hepatitis B virus, human immunodeficiency virus, and other infectious agents to health care personnel. Harborview Medical Center i
ANNA J. 1990 Feb;17(1):44-50, 66. Unique Identifier : AIDSLINE MED/90197309
Moffatt AK
Cytomegalovirus ( CMV ) is a particular threat to the patient with AIDS. Retinitis that may progress to blindness is one of the most distressing manifestations of CMV. DHPG (Ganciclovir) has been used with some success in the treatment of CMV retinitis. This artic
Bukrinskaya AG; Sharova NK; D. I. Ivanovsky Institute of Virology, U.S.S.R. Academy of; Medical Sciences, Moscow.
The treatment of HIV-1 virions with ionic and nonionic detergents (NP 40, octylglucoside, Na deoxycholate) resulted in an effect unusual for enveloped viruses: instead of solubilization of glycoproteins, the core protein p24 was solubilized while envelope glycoproteins with other structural proteins were found in subv
Unified procedures to control those infections that are transmitted by inoculation of blood are recommended. These should be applied to patients with acquired immune-deficiency syndrome (AIDS), AIDS-related complex, persistent generalized lymphadenopathy or hepatitis B, those with serological evidence of infection by
J Immunol. 1990 Mar 1;144(5):1705-10. Unique Identifier : AIDSLINE MED/90171561
Portnoi D; Stall AM; Schwartz D; Merigan TC; Herzenberg LA; Basham T; Department of Genetics, Stanford University School of Medicine,; CA 94305.
Using flow cytometry technology and multiparameter analyses, we report early and characteristic alterations in lymphoid cell profile in spleen and lymph nodes due to LP-BM5 retrovirus disease (murine AIDS (MAIDS)) and the effect of azido dideoxythymidine, a nucleoside inhibitor, on these changes. MAIDS has been charac
Polydefkis M; Koenig S; Flexner C; Obah E; Gebo K; Chakrabarti S; Earl PL; Moss B; Siliciano RF; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21205.
Human CD4+ T cell clones and cell lines were shown to lyse recombinant vaccinia virus-infected cells that synthesize the HIV-1 envelope glycoprotein gp160. The processing of endogenously synthesized gp160 for recognition by CD4+ T cells required that the protein, after synthesis on the rough endoplasmic reticulum and
We investigated the ability of urinary neopterin concentrations and T-cell subset data, and their ratios to discriminate between anti-HIV-1 seronegatives, seropositives, and AIDS cases. Using receiver-operated-characteristics curves, neopterin levels were shown to provide the best discrimination. Of the ratios derived
Lancet. 1990 Mar 3;335(8688):516-9. Unique Identifier : AIDSLINE MED/90173555
Peckham CS; Tedder RS; Briggs M; Ades AE; Hjelm M; Wilcox AH; Parra-Mejia N; O'Connor C; Department of Paediatric Epidemiology, Institute of Child Health,; London, UK.
This pilot study established that unlinked anonymous testing of dried blood spots routinely collected on Guthrie cards for neonatal screening is a feasible method for monitoring HIV prevalence in women at the time of delivery. The method was sensitive, specific, and less expensive than more conventional ELISAs. 114,51
Hilgartner MW; Department of Pediatrics Hematology/Oncology, New York; Hospital-Cornell University Medical Center, NY 10021.
In summary: We have presented 1) data which supports the observation that the progression of immune impairment to AIDS in HIV infected children, adolescents and young adults is significantly slower than in the older adult. 2) Preliminary data suggesting that a relationship may exist between somatic growth and developm
Philos Trans R Soc Lond B Biol Sci. 1990 Jan 30;326(1235):179-87. Unique Identifier : AIDSLINE MED/90175644
Bestor TH; Department of Anatomy and Cellular Biology, Harvard Medical; School, Boston, Massachusetts 02115.
The amino acid sequence of mammalian DNA methyltransferase has been deduced from the nucleotide sequence of a cloned cDNA. It appears that the mammalian enzyme arose during evolution via fusion of a prokaryotic restriction methyltransferase gene and a second gene of unknown function. Mammalian DNA methyltransferase cu
Lancet. 1990 Mar 17;335(8690):619-21. Unique Identifier : AIDSLINE MED/90190086
Surtees R; Hyland K; Smith I; Department of Child Health, Institute of Child Health, London,; UK.
To assess methyl-group metabolism in the central nervous system in infection with human immunodeficiency virus (HIV), levels of 5-methyltetrahydrofolate, methionine, and S-adenosylmethionine were measured by high-performance liquid chromatography in cerebrospinal fluid (CSF) from six children with congenital HIV infec
Lancet. 1990 Mar 24;335(8691):679-82. Unique Identifier : AIDSLINE MED/90190134
Reisinger EC; Kern P; Ernst M; Bock P; Flad HD; Dietrich M; Clinical Department, Bernhard Nocht Institute for Tropical; Medicine, Hamburg, West Germany.
60 patients with HIV-1 infection in Walter Reed stages 2-4 were randomised to treatment with intravenous or oral dithiocarb (diethyldithiocarbamate, DTC) or placebo for 24 weeks in a paired double-blind design. 55 patients were evaluable at the end of the study: no patient who had received DTC but 6 placebo patients h
Volberding PA; Lagakos SW; Koch MA; Pettinelli C; Myers MW; Booth DK; Balfour HH Jr; Reichman RC; Bartlett JA; Hirsch MS; et al; University of California, San Francisco.
Zidovudine ( AZT ) is a potent inhibitor of the replication of the human immunodeficiency virus (HIV), and it has been shown to improve survival in advanced HIV disease. We conducted a randomized, double-blind trial in adults with asymptomatic HIV infec
Am J Psychiatry. 1990 Apr;147(4):495-7. Unique Identifier : AIDSLINE MED/90196384
Rabkin JG; Harrison WM; New York State Psychiatric Institute, NY 10032.
Eleven men with major depression and human immunodeficiency virus (HIV) infection underwent an open trial of imipramine. Eight of nine (89%) who completed 12 weeks responded. The mean decline in T4 cells from baseline was 100 at week 12 and 16 at week 26. No major exacerbations of HIV infection occurred.
J Immunol. 1990 Mar 1;144(5):1677-83. Unique Identifier : AIDSLINE MED/90171557
Mills KH; Kitchin PA; Mahon BP; Barnard AL; Adams SE; Kingsman SM; Kingsman AJ; National Institute for Biological Standards and Control, South; Mimms, Potters Bar, Herts, UK.
We have investigated Th cell recognition of the HIV core protein p24 by using CD4+ T cell clones derived from cynomolgus macaques immunized with hybrid HIV p24: Ty virus-like particles (VLP). T cell lines from two immunized animals responded to p24: Ty-VLP, control Ty-VLP, purified p24, and whole inactivated HIV, indi
J Immunol. 1990 Mar 1;144(5):1684-8. Unique Identifier : AIDSLINE MED/90171558
Nishimura M; Adachi A; Maeda M; Akiguchi I; Ishimoto A; Kimura J; Department of Neurology, Faculty of Medicine, Kyoto University,; Japan.
To study the possible involvement of human T lymphotrophic virus type I (HTLV-I) or a related retrovirus in Japanese cases of multiple sclerosis (MS), we first performed a Western blot analysis with purified Ag of HTLV-I. Ten out of 31 MS patients (32.2%), 19 of 66 patients (28.8%) with other neurologic diseases, and
Lancet. 1990 Mar 10;335(8689):565-8. Unique Identifier : AIDSLINE MED/90173599
Lewis SH; Reynolds-Kohler C; Fox HE; Nelson JA; Department of Obstetrics and Gynecology, College of Physicians; and Surgeons, Columbia University, New York, NY 10032.
AIDS in children is usually caused by vertical transmission of human immunodeficiency virus type 1 (HIV-1). Aborted eight-week fetal and placental tissue from HIV-1 positive and negative (enzyme-linked immunosorbent assay and Western blot) women was analysed by immunocytochemistry and in-situ hybridisation. Maternal d
Furlini G; Re MC; Musiani M; Zerbini ML; La Placa M; Microbiology Institute, University of Bologna, St. Orsola; Hospital, Italy.
Rapid exposure to supra-optimal temperature (heat-shock) and a variety of other treatments are able to induce changes in cellular translational and transcriptional activity referred to as the heat-shock response. The effect of heat-shock was investigated in H9 lymphoblastic cells and in peripheral blood lymphocytes in
Mo Med. 1990 Jan;87(1):26-8. Unique Identifier : AIDSLINE MED/90174056
Raju PI; Roy T; Knight W 3d; Ahuja S; McDonald R; Department of Radiation Oncology and Hematology/Oncology, St.; Louis University Hospital, Missouri.
Kaposi s sarcoma is a common manifestation of AIDS, particularly in young male homosexual patients. Between 1987 and 1988, eight patients with Epidemic Kaposi s sarcoma received palliative radiation therapy. The authors experience indicates that radiation therapy can provide good to excellent palliation for skin and
Bordier B; Tarrago-Litvak L; Sallafranque-Andreola ML; Robert D; Tharaud D; Fournier M; Barr PJ; Litvak S; Sarih-Cottin L; Institut de Biochimie Cellulaire et Neurochimie du CNRS,; Bordeaux, France.
Human immunodeficiency virus (HIV) reverse transcriptase (RT) uses host tRNA(Lys) partially annealed to the primer binding site (PBS) as primer for the initiation of cDNA synthesis. When assaying cDNA synthesis with a template-primer complex formed by an RNA fragment carrying the PBS site and bovine tRNA(Lys) we notic
Shioda T; Shibuta H; Department of Viral Infection, University of Tokyo, Japan.
We constructed a recombinant vaccinia virus carrying the entire gag and pol genes of human immunodeficiency virus type 1 (HIV-1). The main gene product detected in the lysates of infected CV-1 and SW480 cells was the gag precursor protein. However, in the culture fluid of infected SW480 cells, but not of infected CV-1
The principles of viral vaccine development and the immune responses to vaccination are described. An effective vaccine should stimulate both cellular and humoral immune responses to provide lasting protection against infection and disease. We describe specific problems associated with the development of an AIDS vacci
Biochem Biophys Res Commun. 1990 Feb 28;167(1):244-50. Unique Identifier : AIDSLINE MED/90179757
Dudding LR; Harington A; Mizrahi V; Molecular Biology Laboratory, School of Pathology, South African; Institute for Medical Research, Johannesburg.
Endoribonucleolytic cleavage by the ribonuclease H activity associated with HIV-1 reverse transcriptase was observed in vitro using substrates consisting of synthetic oligodeoxynucleotides hybridized to a 345 nucleotide T7 RNA polymerase transcript derived from the gag region of HIV-1. This observation suggests that a
Neumuller M; Karlstrom AR; Kallander CF; Gronowitz JS; Research Unit of Replication Enzymology, Uppsala University,; Sweden.
A one-step procedure which uses enzymes in a crude extract of herpes simplex virus (HSV) type 1-infected cells to synthesize 5-[125I]iodo-2 -deoxyuridine triphosphate [( 125I]dUTP) from [125I]dU is described. The design of a one-step procedure for the purification of the product is also presented. The recovery of [125
Chen JH; Le SY; Shapiro B; Currey KM; Maizel JV; Division of Cancer Biology and Diagnosis, National Cancer; Institute, National Institutes of Health, Frederick, MD 21701.
In our recent series of papers, we have used the structures of statistical significance from Monte Carlo simulations to improve the predictions of secondary structure of RNA and to analyze the possible role of locally significant structures in the life cycle of human immunodeficiency virus. Because of intensive comput
Retroviruses encode proteinases necessary for the proteolytic processing of the viral gag and gag-pol precursor proteins. These enzymes have been shown to be structurally and functionally related to aspartyl proteinases such as pepsin and renin. Cerulenin is a naturally occurring antibiotic, commonly used as an inhibi
HIV-positive Patients often suffer from the symptoms of accompanying diseases. Palliative radiation therapy of associated tumors leads to an improvement of the patient s condition. Particularly skin tumors, which give rise to pronounced itching and ulcerating, are eliminated fast and safe by radiation therapy. Between
J Immunol. 1990 Mar 15;144(6):2131-9. Unique Identifier : AIDSLINE MED/90187852
Hillman K; Shapira-Nahor O; Gruber MF; Hooley J; Manischewitz J; Seeman R; Vujcic L; Geyer SJ; Golding H; Division of Virology, National Institute of Dental Research,; National Institutes of Health, Bethesda, MD 20892.
This study describes the derivation of a series of mutants from the human leukemic cell line CEM using the frame shift mutagen Ethyl-methanesulfonate followed by negative selection with multiple treatments of OKT4A + C, and sorting into CD4-, CD4-dull, and CD4-intermediate mutants. These mutants express reduced CD4 le
J Immunol. 1990 Mar 15;144(6):2152-8. Unique Identifier : AIDSLINE MED/90187855
Mann DL; Gartner S; Le Sane F; Buchow H; Popovic M; Laboratory of Viral Carcinogenesis, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20895.
Monocyte/macrophages (MM) were isolated from HIV-1 seronegative individuals, infected with HIV-1 and examined for their ability to infect autologous T lymphocytes with and without concomitant presentation of exogenous Ag. HIV-1-infected MM presented tetanus toxin (TT) and streptokinase to T cells (as measured by [3H]t
Boucher CA; Krone WJ; Goudsmit J; Meloen RH; Naylor PH; Goldstein AL; Sun DK; Sarin PS; Human Retrovirus Laboratory, University of Amsterdam, The; Netherlands.
A thirty amino acid synthetic peptide (HGP30) representing the conserved region of HIV-1 p17 induced high titer antibodies to the native p17 in rabbits. This immune sera neutralized HIV-1 replication in cell culture and one of the high titer antisera also inhibited CD4-dependent cell fusion. Pepscan analysis with over
Fultz PN; Stricker RB; McClure HM; Anderson DC; Switzer WM; Horaist C; Yerkes Regional Primate Research Center, Emory University,; Atlanta, Georgia 30322.
Natural infection of sooty mangabey monkeys with simian immunodeficiency virus, designated SIV/SMM, results in long-term persistent infections with little or no disease. In contrast, experimental infection of macaques with isolates of SIV/SMM induces chronic and progressive disease that terminates in an AIDS-like illn
Witvrouw M; Baba M; Balzarini J; Pauwels R; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
Dextran sulfate and pentosan polysulfate are two promising candidate anti-acquired immune deficiency syndrome (AIDS) drugs that have already been the subject of initial clinical trials in patients with AIDS. There is at present no reliable assay method to monitor blood drug levels in humans following the administratio
Tremblay M; Numazaki K; Goldman H; Wainberg MA; Lady Davis Institute, Sir Mortimer B. Davis-Jewish General; Hospital, Montreal, Quebec, Canada.
We have succeeded in infecting human thymic lymphocytes with both the HIV-IIIB laboratory strain of HIV-1 as well as with a clinical isolate of this virus. Thymic lymphocytes were at least as susceptible to infection by HIV-1 as were cord blood lymphocytes, but appeared to display somewhat greater resistance to the cy
Wells CL; Rhame FS; Department of Laboratory Medicine, University of Minnesota,; Minneapolis 55455.
Oral dextran sulfate is associated with adverse intestinal effects, including severe diarrhea, in some AIDS patients. We therefore investigated the intestinal flora and the intestinal histology of mice given drinking water supplemented with 8 mg/ml of dextran sulfate. There were no noticeable alterations in the major
Hafkemeyer P; Neftel KA; Hubscher U; Institute of Pharmacology and Biochemistry, University; Zurich-Irchel, Switzerland.
Penicillin-binding proteins are the specific targets for the beta-lactam antibiotics. Recently it was observed that beta-lactam antibiotics also have targets in proliferating eukaryotic cells (1), one of which most likely is the replicative DNA polymerase alpha. Here we show that HIV-reverse transcriptase and human DN
Proc Natl Acad Sci U S A. 1990 Mar;87(6):2344-8. Unique Identifier : AIDSLINE MED/90192804
Hosmalin A; Clerici M; Houghten R; Pendleton CD; Flexner C; Lucey DR; Moss B; Germain RN; Shearer GM; Berzofsky JA; Metabolism Branch, National Cancer Institute, National Institutes; of Health, Bethesda, MD 20892.
T-cell-mediated cytotoxicity may play an important role in control of infection by the human immunodeficiency virus (HIV). In this study, we have identified and characterized a relatively conserved epitope in the HIV-1 reverse transcriptase recognized by murine and human cytotoxic T cells. This epitope was identified
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