New York, NY : Trustees of Columbia University, c1986 1 videocassette (60 min.) : sd., col. ; 1/2 in (Managing our miracles ; program no. 105) Unique Identifier : AIDSLINE AV/9000241A
(Producer) The clinical and biologic significance of cervical lymph nodes makes their identification on images vital. Intelligent communication of findings requires that the radiologist be familiar with the anatomic location and organization of the cervical nodes and the terminology needed to relate these findings to
(Producer) This videotape discusses patients infected with the Human Immunodefiency Virus (HIV) who are presently being given emergency care or are being hospitalized in many areas of the United States . Dr. Perlino then talks about the risk of acquiring HIV infection in the work setti
Phoenix : Oryx Press, v (Oryx science bibliographies ; v. 1, etc.) Unique Identifier : AIDSLINE CAT/9000808
Topical listing of selected, evaluated, and current references on AIDS. Intended for undergraduate level ; contains only English-language materials. Topical arrangement. Entries give bibliographic information and annotation. Bold faced citations indicate the most important references. Author index.
Transmissiveis/AIDS [Brazil : Ministerio da Saude, Secretaria Nacional de Programas Especiais de Saude, Divisao de Doencas Sexualmente Transmissiveis e SIDA/AIDS, v. : ill Unique Identifier : AIDSLINE CAT/9001291
New York, NY (61 West 62nd St., New York 10023) : Greater New York Hospital Foundation, c1988 1 v. (loose leaf) : ill Unique Identifier : AIDSLINE CAT/9000806
Dar es Salaam : Tanzania National Documentation Centre, National Central Library, 1988 iii, 24 leaves (Special subject bibliography series ; no. 1) Unique Identifier : AIDSLINE CAT/9000807
Wellingborough, Northamptonshire, England : Thorsons ; New York, N.Y. : Distributed by Sterling Pub. Co., 1988 288 p Unique Identifier : AIDSLINE CAT/9001264
London ; New York : Royal Society of Medicine Services, 1988 xi, 194 p. : ill (International congress and symposium series ; no. 141) Unique Identifier : AIDSLINE CAT/9001285
Centres Copenhagen : World Health Organization, Regional Office for Europe ; Albany, NY : United States of America, WHO Publications Center USA [distributor], c1988 v, 27 p Unique Identifier : AIDSLINE CAT/9001513
New York, N.Y. : American Foundation for AIDS Research : Distributed by R.R. Bowker, 1989 viii, 270 p Unique Identifier : AIDSLINE CAT/9000951
Halleron TA; Pisaneschi JI; Trapani M
Intended as a reference tool for educators, service providers, program managers, policy makers and other individuals interested in or affected by the AIDS/HIV epidemic. Printed and audiovisual materials. Entries give identifying, descriptive, and review information. Indexes by titles, format, and titles other than
Pacific Haemophilia with Special Reference to AIDS and HIV Infection Manila, Philippines : Regional Office for the Western Pacific of the World Health Organization, [1989] 16 p Unique Identifier : AIDSLINE CAT/9001486
Cancer Growth Prog; 4:133-8 1989. Unique Identifier : AIDSLINE ICDB/90657750
Brunson KW; Goldfarb RH; Dept. of Infectious Diseases, Pfizer Central Res., Eastern Point; Rd., Croton, CT 06340
The role of the immune response in preventing or limiting tumor growth and in affecting metastases has long been debated. A consensus has emerged that the major components of the immune system involved in surveillance and tumor cell killing are cell-mediated: T-cell-mediated cytotoxicity, macrophage-mediated cytotoxic
Scott DW; Univ. of Rochester Cancer Center and Sch. of Medicine and; Dentistry, Rochester, NY
Vertebrates have evolved an immune system consisting of both specific and nonspecific defense barriers, which interface with one another to protect the integrity of the organism in a hostile environment. Once potentially pathogenic agents pass through the first lines of defense (skin and mucosal tissues), they interac
Raab-Traub N; Pagano JS; Lineberger Cancer Res. Center, Sch. of Medicine, Univ. of North; Carolina, Chapel Hill, NC
The Epstein-Barr virus (EBV) is the only well-characterized virus known to infect human B lymphocytes. This ubiquitous agent infects human beings universally. An EBV infection also evokes striking cell-mediated immune responses, both specific and nonspecific, as part of a host response to a unique consequence of EBV i
Joshi VV; Morrison S; Connor EM; Marquis J; Oleske JM; Dept. of Pathology, Children's Hosp. of New Jersey, United; Hospitals Medical Center, Newark, NJ
Since the recognition of pediatric AIDS, pulmonary lesions have been of special clinical significance because of their role in the diagnosis and management of the syndrome. Data are reported for a total of 33 children (20 boys, 13 girls; 5 mo to 7 yr old; many with two lesions); lung biopsies were done in 21 patients
Taniguchi T; Fujita T; Yamada G; Hatakeyama M; Ishizaka E; Miyamoto M; Maruyama M; Shibuya H; Institute for Molecular and Cellular Biology, Osaka University,; Japan.
Cytokines represent essential soluble mediators in cell-to-cell communication and they are known to play crucial roles in many biological processes, including viral infection, inflammation and immunity. We have been focusing on two cytokine systems, the interferon (IFN) and interleukin 2 (
Miller AR; Griffin GE; Batman P; Farquar C; Forster SM; Pinching AJ; Harris JR; Department of Communicable Diseases, St George's Hospital Medical; School, Tooting, London.
Diarrhoea and weight loss are common features of human immunodeficiency virus (HIV) disease. The mechanism of diarrhoea occurring in the absence of known enteropathogens is currently unknown. We have measured fat absorption, using the 14C triolein breath test, and quantitatively assessed jejunal villous architecture i
Vitetta ES; Department of Microbiology, University of Texas Southwestern; Medical Center, Dallas 75235.
Immunotoxins (ITs) consist of cell-reactive ligands coupled to toxins or their toxic subunits. The ligands are usually antibodies, hormones, or growth factors and the toxins are of bacterial or plant origin. In the case of the plant toxin, ricin, its structure consists of a ribosome-inactivating A chain of 32 Kd linke
Trans Assoc Am Physicians. 1988;101:212-8. Unique Identifier : AIDSLINE MED/90070372
Markowitz DG; Goff SP; Bank A; Department of Genetics and Development, Columbia University,; College of Physicians and Surgeons, New York, New York 10032.
The construction of a retrovirus packaging cell line which produces high-titer, helper-free retrovirus is an essential prerequisite for experiments whose goal is gene therapy. We have constructed an ecotropic packaging cell line, GP + E-86, and an amphotropic packaging cell line, GP + envAm12, in which the viral gag a
Yodoi J; Tagaya Y; Masutani H; Maeda Y; Kawabe T; Institute for Immunology, Faculty of Medicine, Kyoto University,; Japan.
Lymphocyte transformation/activation is accompanied by the induction of a variety of the inducible receptors associated with the activation antigens. The p55 chain of the interleukin-2 receptor (IL-2R/p55) recognized by anti-Tac monoclonal antibody (mAb) is expressed on activated T and B cells as well as natural kille
Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, Maryland 20853.
Human retroviruses (HTLV-I, HTLV-II, HIV-1, and HIV-2) and some human herpes viruses (notably EBV and HHV-6 or HBLV) infect chiefly target cells of the immune system. They can alter function of these cells, leading to many side effects, including mild (HTLVs), transient (EBV, HHV-6), or profound (HIVs) immune impairme
Mariotti M; Lefrere JJ; Noel B; Ferrer-le-Coeur F; Vittecoq D; Girot R; Courouce AM; Salmon C; Rouger P; Institut National de Transfusion Sanguine, Universite Pierre et; Marie Curie (UER St-Antoine), Paris, France.
Polymerase Chain Reaction (PCR) allows the amplification of specific segments of Human Immunodeficiency Virus (HIV) genome. This technique is of interest for direct detection of HIV-1 DNA sequences in peripheral blood mononuclear cells. In our study, 54 out of 55 HIV-1 seropositive subjects were found positive with PC
Courouce AM; Baudelot J; Elghouzzi MH; Gueguen M; Janot C; Lemaire JM; Maniez M; Mesnier F; Noel L; North ML; et al; Fondation Nationale de Transfusion Sanguine, Paris.
Human T-lymphotropic virus type I (HTLV-I) has been recently found to be associated with slowly progressive myelopathy. We have seen 12 patients with HTLV-I associated myelopathy (HAM), three of whom showed retinal vasculitis. In addition two patients had ocular symptoms of vitreous opacity. Retinal vasculitis in thes
Fox HB; Gutman PD; Dave HP; Cao SX; Mittelman M; Berg PE; Schechter AN; Laboratory of Chemical Biology, National Institute of Diabetes,; Digestive and Kidney Diseases, Bethesda, MD 20892.
We studied the effects of a known retroviral trans-activating factor, HTLV-I tax1, on transcription of human globin genes. Transfection of HeLa cells by the cloned tax1 gene stimulated activity of both the beta- and epsilon-globin promoters approximately 20-fold, as measured by chloramphenicol acetyl transferase (CAT)
Blau IW; Elstner E; Waechter M; Ihle R; von Janta-Lipinski M; Langen P; Clinic of Internal Medicine, Department of Haematology, Charite,; Humboldt University, Berlin.
3 -Deoxy-3 -fluorothymidine (FT), a thymidine analogue highly effective against HIV 1 in vitro was investigated as to its in vitro effect on normal human bone marrow CFU-GM (agar colony assay) and on human peripheral myeloid leukaemic clonogenic cells (CFU-L, colony assay in methylcellulose). For comparison, 3 -azido-
Shin MS; Liendo C; Ho KJ; Department of Radiology School of Medicine, University of Alabama; Birmingham.
Pneumocystis carinii pneumonia in a 52-year-old homosexual AIDS patient is described because of its unusual manifestations of multiple cavitary and noncavitary peripheral pulmonary nodules and spontaneous pneumothorax. Such manifestations might become more common in the future because of the improvement of diagnostic
Cancer. 1989 Dec 15;64(12):2424-30. Unique Identifier : AIDSLINE MED/90058398
Epstein JB; Lozada-Nur F; McLeod WA; Spinelli J; Cancer Control Agency of British Columbia, Vancouver, Canada.
Treatment of palatal Kaposi s sarcoma (KS) with intralesional injection of vinblastine was seen to provide effective palliation. Of the ten patients studied, four had a 25% to 50% response, two 50% to 75% response, and four had 75% to 100% response with one or two intralesional injections of vinblastine. Response to t
Cancer. 1989 Dec 15;64(12):2515-24. Unique Identifier : AIDSLINE MED/90058412
Yoshida T; Kikuchi M; Ooshima K; Takeshita M; Kimura N; Kozuru M; Satoh H; First Department of Pathology, School of Medicine, Fukuoka; University, Japan.
Proviral DNA of adult T-cell leukemia virus (HTLV-I) was examined by the standard Southern blotting method in lymph nodes of 45 patients with anti-HTLV-I antibody (ATLA)-positive adult T-cell leukemia/lymphoma (ATLL). Six of these patients revealed no monoclonal proviral HTLV-I DNA in tumor cells. These six patients s
Cancer. 1989 Dec 15;64(12):2585-7. Unique Identifier : AIDSLINE MED/90058422
Shaw MT; Jacobs SR; Department of Medicine, Maricopa Medical Center, Phoenix, Arizona; 85010.
A 22-year-old man with human immunodeficiency virus infection had skin nodules of the chest wall. When a biopsy was performed on these nodules, Hodgkin s disease was discovered. The patient was subsequently found to have widespread disease involving the lymph nodes and liver. Skin involvement with Hodgkin s disease is
Feinfeld DA; Kaplan R; Dressler R; Lynn RI; Baumritter Kidney Center, Albert Einstein College of Medicine,; Bronx, New York 10583.
It has recently been reported that patients on maintenance dialysis with the acquired immune deficiency syndrome (AIDS) survive only 1 to 3 months. We studied all patients on maintenance dialysis at the Baumritter Kidney Center who were known to be infected with the human immunodeficiency virus (HIV). Five patients me
de Miranda P; Good SS; Yarchoan R; Thomas RV; Blum MR; Myers CE; Broder S; Wellcome Research Laboratories, Research Triangle Park, NC.
The anti-human immunodeficiency virus drug zidovudine is metabolized extensively in human beings to the 5 -glucuronide (GAZT) and is cleared rapidly, resulting in a short half-life and the need for frequent dosing. This study explores whether probenecid, which is also metabolized by glucuronidation, reduces zidovudine
Polish LB; Cohn DL; Ryder JW; Myers AM; O'Brien RF; Department of Medicine, Denver Department of Health and; Hospitals, Colorado.
Whereas extralymphatic involvement is common in lymphomas associated with HIV infection, there have been few reports of pulmonary lymphoma. In 648 cases of AIDS reported in Colorado, 40 have had non-Hodgkin s lymphoma . Of these, four have had documented pulmonary involvement and ar
EMBO J. 1989 Dec 1;8(12):3641-9. Unique Identifier : AIDSLINE MED/90059963
Pelchen-Matthews A; Armes JE; Marsh M; Chester Beatty Laboratories, Institute of Cancer Research,; London, UK.
The internalization of CD4, a T cell differentiation antigen and the receptor for the human immunodeficiency viruses (HIV-1 and 2), has been examined in HeLa and murine 3T3 cells transfected with CD4 cDNA. Fab fragments of the anti-CD4 monoclonal antibody Leu3a were generated by pepsin digestion and used as a specifi
202 patients with HIV infections of different stages [1 (n = 59): symptomless HIV seropositivity, 2 (n = 64): pre-AIDS (LAS = Lymphadenopathy syndrome, ARC = AIDS related complex), 3 (n = 79): AIDS] were prospectively examined. The findings of the first examination were analyzed statistically in a cross-section-study.
Pezzella M; Caprilli F; Vonesch N; Cordiali-Fei P; Gentili G; Sturchio E; Mannella E; Institute of Infectious Diseases, University of Rome La Sapienza,; Italy.
The presence of the human immunodeficiency virus (HIV) genome was investigated by applying in situ hybridisation techniques to peripheral blood mononuclear cells (PBMCs). Twenty asymptomatic anti-HIV seronegative homosexual men were the subjects of our study. The cells were hybridised with: (1) an SP 64 plasmid contai
Ijichi S; Eiraku N; Osame M; Izumo S; Kubota R; Maruyama I; Matsumoto M; Niimura T; Sonoda S; Third Department of Internal Medicine, Faculty of Medicine,; Kagoshima University, Japan.
In order to detect activated T lymphocytes in the cerebrospinal fluid (CSF) of patients with human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP), we studied CSF lymphocytes in untreated patients with HAM/TSP and other neurological diseases (OND). Dual-immunofluoresce
Armstrong-Esther C; Hewitt WE; School of Nursing, University of Lethbridge, Alberta, Canada.
Within the growing literature on AIDS, relatively little attention has been paid to the public s knowledge and perception of the disease. Even less is known about nurse s understanding of, and attitudes towards AIDS, even though in large part, the treatment and care of AIDS patients rests in their hands. As a partial
Jungbauer A; Tauer C; Wenisch E; Steindl F; Purtscher M; Reiter M; Unterluggauer F; Buchacher A; Uhl K; Katinger H; Institute of Applied Microbiology, University of Agriculture and; Forestry, Vienna, Austria.
Human monoclonal antibodies against the transmembrane protein gp41 of HIV-1 were isolated and purified on a pilot scale. A purification scheme was established for the production of human monoclonal antibodies on the gram scale. 50 1 of culture supernatant can be treated in one purification cycle. The hybridomas were m
Riedel L; Segal I; Mohamed AE; Hale M; Mannell A; Gastroenterology Unit, Baragwanath Hospital, Bertsham, South; Africa.
Review of biopsy specimens showed that a patient incorrectly diagnosed 7 years ago as having Crohn s disease actually had histologically proven gastrointestinal tuberculosis of 7 years duration. It is significant that gastrointestinal tuberculosis and Crohn s disease can mimic each other not only in their clinical, r
J Immunol. 1989 Dec 1;143(11):3602-8. Unique Identifier : AIDSLINE MED/90063047
Norrby E; Parks DE; Utter G; Houghten RA; Lerner RA; Department of Virology, School of Medicine, Stockholm, Sweden.
The immunochemistry of two homologous uniquely antigenic peptides representing Ala582 to Cys604 in the transmembrane proteins of simian immunodeficiency virus of rhesus macaque origin, SIVmac (closely related to HIV-2) and HIV-1 (strain HTLV-IIIB) was characterized at the resolution of single amino acids. Five differe
Guthertz LS; Damsker B; Bottone EJ; Ford EG; Midura TF; Janda JM; Microbial Diseases Laboratory, California Department of Health; Services, Berkeley 94704.
A genetic probe (Gen-Probe) was used to evaluate potential epidemiologic and susceptibility differences of Mycobacterium avium complex (MAC) strains isolated from 154 patients with and without the acquired immunodeficiency syndrome (AIDS). Genetic analysis revealed that 98% of the 45 patients with AIDS harbored only M
Verghese A; Berk SL; Sarubbi F; Department of Medicine, Veterans Administration Medical Center,; Johnson City TN.
Although the AIDS Commentaries published over the past 18 months have focused on clinical questions relevant to all practicing infectious diseases physicians, they have emphasized clinical information gathered from the large epicenters of the epidemic. We need to remember that clinicians dealing with HIV-infected pati
Bigbee PD; Sarin PS; Humphreys JC; Eubanks WG; Sun D; Hocken DG; Thornton A; Adams DE; Simic MG; Forensic Science Research and Training Center, FBI Academy,; Quantico, VA.
A method to use ionizing radiation to inactivate HIV (Human Immunodeficiency Virus) in human body fluids was studied in an effort to reduce the risk of accidental infection to forensic science laboratory workers. Experiments conducted indicate that an X-ray absorbed dose of 25 krad was required to completely inactivat
Petersen J; Church J; Gomperts E; Parkman R; Childrens Hospital of Los Angeles, Division of Research; Immunology/Bone Marrow Transplantation, CA 90027.
To determine whether assays of lymphocyte phenotype were predictive of antigen-specific immunologic function in children infected with human immunodeficiency virus type 1 (HIV-1), we compared the antigen-specific cellular and humoral functions (tetanus toxoid-induced T lymphocyte blastogenesis and anti-tetanus toxoid
Gardner LI Jr; Brundage JF; Burke DS; McNeil JG; Visintine R; Miller RN; Department of Epidemiology, Walter Reed Army Institute of; Research, Washington, D.C. 20307-5100.
Reports of an increased proportion of AIDS cases occurring in small and medium-sized cities suggest that the HIV epidemic may be spreading into locations that were previously characterized by their low HIV antibody prevalences. Studying the question of the geographic spread of the HIV infection epidemic (rather than t
Battjes RJ; Pickens RW; Amsel Z; National Institute on Drug Abuse, Rockville, MD 20857.
To explore the introduction of human immunodeficiency virus (HIV) infection into intravenous drug abusing populations, risk behaviors of 1,154 intravenous drug abusers (IVDAs) in four U.S. cities with low prevalence of IVDA/HIV infection (0.9-13.0%) were examined. Seropositive subjects (N = 54) were compared with demo
de-The G; Giordano C; Gessain A; Howlett W; Sonan T; Akani F; Rosling H; Carton H; Mouanga Y; Caudie C; et al; CNRS Laboratory of Epidemiology and Immunovirology of Tumors,; Faculty of Medicine Alexis Carrel, Lyon, France.
HTLV-I is associated with tropical spastic paraparesis (TSP) in the Caribbean area and with certain chronic myelopathies termed HAM (HTLV-I-associated myelopathy) in Japan . In order to investigate the situation in Africa, we tested for HTLV-I, but also for HIV-1 and HIV-2 antibodies
Colebunders RL; Lebughe I; Nzila N; Kalunga D; Francis H; Ryder R; Piot P; Department of Public Health, Belgian-Zairian Medical Cooperation,; Kinshasa, Belgium.
Cutaneous delayed-type hypersensitivity (DTH) reactions were assessed by the CMI-Multitest (Merieux, Lyon, France ) in patients with different stages of human immunodeficiency virus (HIV) infection in Kinshasa, Zaire . Skin tests were read after
Dokhelar MC; Pickford H; Sodroski J; Haseltine WA; Division of Human Retrovirology, Dana-Farber Cancer Institute,; Boston, Massachusetts.
The human T cell leukemia/lymphoma virus type I (HTLV-I) encodes two regulatory proteins, a 42 kDa trans-activator protein (p42tax) and a 27 kDa protein (p27rex), required for virus capsid protein synthesis. The experiments described here show that the p27rex protein negatively regulates the expression of the p42tax p
Schild GC; Cope JE; National Institute for Biological Standards and Control,; Hertfordshire, Great Britain.
In 1987 the U.K. Medical Research Council established a Directed Programme of AIDS Research, the primary objective of which is the development of vaccines and therapeutic approaches against HIV infection and AIDS. The Programme s activities have been rapidly built up and by mid-1989 comprised some 130 individual resea
Hedaya MA; Sawchuk RJ; Department of Pharmaceutics, College of Pharmacy, University of; Minnesota, Minneapolis 55455.
The effect of probenecid on the renal excretion of zidovudine (3 -azido-3 -deoxythymidine; AZT ) and its distribution into CSF was studied in the rabbit. Although probenecid is chemically unrelated to AZT, it has been shown that probenecid inhibits AZT
Wanzala P; Manji F; Pindborg JJ; Plummer F; Kenya Medical Research Institute, Nairobi.
In Nairobi ( Kenya ) 334 women prostitutes of whom 80.5% were HIV-1 positive, were examined for oral mucosal lesions; 15.6% of seropositive, and 4.6% of seronegative, women had oral mucosal lesions, predominantly oral candidiasis. In the seropositives, 8.6% had erythematous, 1.1% had
J Miss State Med Assoc. 1989 Nov;30(11):355-9. Unique Identifier : AIDSLINE MED/90064474
Bailey LG; Johnson BC; Starkey PL; Kellogg CE
This paper reports the results of a study performed to address the many unresolved issues concerning health care workers and their treatment of patients with AIDS. A survey was developed to measure knowledge, attitudes and opinions, and other information of health care workers. The survey was administered to all emplo
Soderstrom CA; Furth PA; Glasser D; Dunning RW; Groseclose SL; Cowley RA; Maryland Institute for Emergency Medical Services Systems,; Baltimore 21201-1595.
Human immunodeficiency virus (HIV) infection rates among 1,497 consecutive adult trauma victims triaged from rural and urban sectors to a statewide trauma center in Baltimore were studied. Those studied were 71.7% men, 77.4% whites, 63.2% vehicular trauma victims, 11.2% assault victims, and 25.7% other trauma victims.
Lowe FC; Lattimer DG; Metroka CE; Department of Urology, St. Luke's, Roosevelt Hospital Center, New; York, New York.
With the growing number of patients with the acquired immunodeficiency syndrome there has been a marked increase in the incidence of Kaposi s sarcoma. Kaposi s sarcoma of the penis was the initial presenting manifestation of acquired immunodeficiency syndrome in 4 patients. Overall, less than 3% of all acquired immuno
JAMA. 1989 Dec 22-29;262(24):3435-8. Unique Identifier : AIDSLINE MED/90064949
Benenson AS; Peddecord M; Hofherr LK; Ascher MS; Taylor RN; Hearn TL; Graduate School of Public Health, San Diego State University, CA; 92182-0405.
We conducted a pilot study of potential sources of incorrect laboratory reports of human immunodeficiency virus type 1 testing using blind proficiency testing. Sets of three serum samples, including one serum sample with negative reactions in antibody tests, one serum sample with positive reactions, and one that gave
We investigated the pretreatment characteristics and prognosis of T-cell lymphomas, including mycosis fungoides (MF), T-cell lymphoma of the skin other than MF (CTL), adult T-cell leukemia/lymphoma (ATL), immunoblastic lymphadenopathy (IBL)-like T-cell lymphoma and angioimmunoblastic lymphadenopathy with dysproteinemi
Kimura I; Tsubta T; Ueda N; Tada S; Yoshimoto S; Sogawa J; Shiraishi T; Tamaki T; Ueno K; Fujita T; et al
A new clinicopathological state related to HTLV-I infection was found in patients with diffuse panbronchiolitis (DPB) and idiopathic interstitial pneumonia (IIP). This specific state with chronic and progressive respiratory symptoms caused by bronchiolar or alveolar disorder was characterized by smoldering adult T-cel
Klin Wochenschr. 1989 Oct 17;67(20):1033-41. Unique Identifier : AIDSLINE MED/90065461
Kamradt T; Niese D; Schneweis KE; Brackmann HH; Kamps B; van Loo B; Hammerstein U; Medizinische Universitatsklinik Bonn, Klinische Immunologie.
At our institution 686 hemophiliacs are being treated. Of them 402 (59%) are anti-HIV-seropositive. The general use of heat-treated clotting factor products was begun in July 1983, and from May 1984 all patients exclusively used heat-treated clotting factors. Thus, one can assume that infection occurred no later than
Windle M; Research Institute on Alcoholism, Buffalo, New York 14203.
A total of 51 (34 men and 17 women) heterosexual alcoholic inpatients were assessed with respect to their engagement in high-risk behaviors for HIV infection and AIDS. Results indicated that a subset of the subjects engaged in frequent and diverse high-risk sexual activities, often had several different sexual partner
Lakartidningen. 1989 Nov 15;86(46):3991-4. Unique Identifier : AIDSLINE MED/90065781
Wahlund LO; Agartz I; Saaf J; Wetterberg L; Marions O
The use of MRI in clinical psychiatry is evaluated on the basis of over four years experience. Of 931 psychiatric patients examined, 156 were found to manifest pathological cerebral conditions, a frequency of 17 per cent, as compared with 2 per cent (2/101) among apparently healthy controls. The occurrence of intrace
Ment Retard. 1989 Aug;27(4):209-11. Unique Identifier : AIDSLINE MED/90066036
Rubinstein A
There was substantial difficulty in the early years of the HIV epidemic in confirming the presence of this infection in children. Serological testing finally allowed the identification of a spectrum of clinical expressions. An understanding gradually developed about the serious central nervous system involvement in ch
Ment Retard. 1989 Aug;27(4):227-8. Unique Identifier : AIDSLINE MED/90066040
Whitney CK
The hemophilia community has been rocked by the catastrophe of AIDS. The use of blood products that had first restored the potential for normal survival turned out also to bring involvement with, or the threat of, HIV infection. Persons with hemophilia are now burdened with fear and discrimination. Strong leadership h
Ment Retard. 1989 Aug;27(4):229-32. Unique Identifier : AIDSLINE MED/90066041
Kastner TA; Nathanson R; Marchetti A; Pincus S
The achievement of community living and greater personal independence has placed adults with developmental disabilities in a potentially vulnerable position regarding acquisition of HIV infection. Early surveys have identified a limited number of individuals who have become infected. Few states have undertaken plannin
Ment Retard. 1989 Aug;27(4):233-7. Unique Identifier : AIDSLINE MED/90066042
Jacobs R; Samowitz P; Levy JM; Levy PH
The AIDS epidemic poses a serious threat to people with developmental disabilities, the magnitude of which has not yet been fully realized by many professionals working with this population. Models for effective AIDS prevention education have been developed, however, within other populations. Key principles utilized i
Ment Retard. 1989 Aug;27(4):241-3. Unique Identifier : AIDSLINE MED/90066044
Connelly JJ
Segregation, based on fear of liability, is being practiced regarding persons with HIV infection. The story is told of 16-year-old Chris, who has mental retardation and a positive blood test for HIV infection. He lost his foster care placement, underwent a lengthy hospital admission, and had a long and complicated pro
Ment Retard. 1989 Aug;27(4):245-8. Unique Identifier : AIDSLINE MED/90066045
West J
An analysis of the interplay between public opinion and public policy in terms of HIV infection yielded a four-stage framework for considering the development of public policy in relation to a highly charged issue. The phases are denial, irrationality, acceptance, and the development of a rational response. As we move
Ment Retard. 1989 Aug;27(4):249-51. Unique Identifier : AIDSLINE MED/90066046
Stavis PF
Modern judicial activism--establishing caselaw that functions as law until statutes are subsequently enacted--has been the hallmark of the variety of legal issues surrounding the HIV condition and AIDS diseases. Most federal and state courts have been compelled to resolve many HIV/AIDS-related controversies in advance
Bonfanti C; Manca N; Caruso A; Gargiulo F; Turano A; Institute of Microbiology, University of Brescia, Italy.
Recent reports have shown that HTLV I infection is widespread and that HIV/HTLV I combined infections may accelerate the progression of seropositive patients towards AIDS. In order to obtain a tool for the detection and identification of HTLV I in cell culture we have developed an antigen-capture ELISA, which is based
Med Hypotheses. 1989 Aug;29(4):241-3. Unique Identifier : AIDSLINE MED/90066102
Rabinoff M; Biology Dept., University of Tennessee, Chattanooga, 37403.
The measurement of urinary neopterin and biopterin may be an important non-specific diagnostic tool. Urinary biopterin has been found to be decreased in parkinsonian patients, and in hyperphenylalanemia as a variant of phenylketonuria. Urinary neopterin has been found to be elevated in numerous conditions. It has been
Wolf J; Hurter P; Kinderkrankenhaus auf der Bult, Hannover.
The clinical course of a perinatal HIV infection in a 3 1/2-year-old girl is presented. The girl became HIV-positive at the age of 6 months, at about the same time as her mother. She is receiving continuous prophylactic treatment with immunoglobulins and cotrimoxazol. The pathological findings and the stage according
N Engl J Med. 1989 Dec 14;321(24):1621-5. Unique Identifier : AIDSLINE MED/90066612
Ho DD; Moudgil T; Alam M; Department of Medicine, UCLA School of Medicine, Cedars-Sinai; Medical Center 90048.
We used end-point-dilution cultures to measure the level of infectious human immunodeficiency virus type 1 (HIV-1) in peripheral-blood mononuclear cells (PBMC) and plasma of 54 infected patients who were not receiving antiviral chemotherapy. HIV-1 was recovered from the plasma and PBMC of every seropositive patient, b
All instrument and needle accidents, and mucosal exposure to blood involving surgical specialists and operating room personnel were recorded for a seven-month period in a middle-sized Amsterdam hospital, the St. Lucas. Fifty-four accidents were reported, of which 42 were percutaneous wounds and 12, blood splatters in
Link H; Cruz M; Gessain A; Gout O; de The G; Kam-Hansen S; Department of Neurology, Karolinska Institutet, Huddinge; University Hospital, Stockholm, Sweden.
Among 22 patients with human T-lymphotropic virus type I (HTLV-I)-associated chronic progressive myelopathy, agarose isoelectric focusing (AIF) revealed oligoclonal IgG bands in 21: in 3 in CSF only; in 11 in CSF and to some extent in serum; and in 7, identical patterns in CSF and serum. By immunoblot after AIF of CSF
Evans BK; Gore I; Harrell LE; Arnold T; Oh SJ; Department of Neurology, University of Alabama Birmingham School; of Medicine.
A patient who had always lived in the United States had an HTLV-I infection and a chronic myelopathy clinically mimicking amyotrophic lateral sclerosis. Needle EMG and nerve conduction studies were consistent with anterior horn cell disease but muscle biopsy showed denervation and an i
Janke J; College of Nursing and Health Sciences, University of Alaska,; Anchorage.
AIDS is a lethal disease that poses a major threat to adolescents who engage in high-risk behaviors such as unsafe sex and IV drug use. It is estimated that 21 percent of individuals diagnosed with AIDS in their 20s were infected as teens. Public health officials maintain that education is the best strategy for limiti
Huszti HC; Clopton JR; Mason PJ; Department of Pediatrics, University of Oklahoma Health Sciences; Center, Oklahoma City.
Although many schools are presenting acquired immunodeficiency syndrome (AIDS) education programs for adolescents, few have evaluated the effects of the programs. The effects of two different types of program presentation, a lecture or a film, were compared to a no-program condition. Students who received the lecture
Rooks CA; School of Nursing, University of Maryland, Baltimore.
Issues relating to treatment of clients with AIDS or HIV infections are not easy to resolve. It is important, however, to understand both sides of the issue prior to determining what actions or policies one might make. The ethical concerns presented here reflected issues related to the principles of autonomy, benefice
Walger P; Baumgart P; Wilke G; Kupfer U; von Eiff M; Dorst KG
After an average observation time of 12 months we can confirm that methadone substitution on an outpatient basis has proved significantly useful for a majority of chronically intravenously opiate-dependent HIV-infected patients of the stages CDC IV or WR 3-6 if methadone is given under controlled conditions, the impro
Brechot JM; Dore MF; Capron F; Bouvet A; Waked M; Rochemaure J; Service de Pneumologie, Hotel Dieu de Paris.
This study concerns 37 cases of Pneumocystis carinii pneumonia in AIDS patients. The time elapsed between human immunodeficiency virus (HIV) seropositivity and the onset of pneumocystosis has been established. Three clinical types are individualized. In cases with normal X-ray films of the chest, measurement of carbon
Cacoub P; Parquin F; Roux P; Carette MF; Mayaud C; Akoun G; Service de Pneumologie et de Reanimation respiratoire, Hopital; Tenon, Paris.
The authors report the case of an AIDS patient presenting with both Streptococcus pneumoniae pneumoniae and pneumocystosis. What was remarkable in that case was the appearance, in an otherwise favourable course, of a large excavation in the territory of the pneumonia. The responsibility of Pneumocystis carinii in this
Gillet JY; Service de Gynecologie-Obstetrique, Hopital Saint-Roch, Nice.
This study reports a particular experiment due to the large proportion of seropositive women followed during pregnancy at the maternity of Nice, where 100 cases were recorded in a little more than two years. The author summarizes the epidemiology and the consequences of the association of pregnancy and AIDS seropositi
Pedersen C; Lundgren JD; Nielsen T; Andersen WH; Department of Infectious Diseases, Hvidovre Hospital, University; of Copenhagen, Denmark.
A total of 100 consecutive patients with AIDS were evaluated for efficacy and safety of treatment and secondary prophylaxis directed against Pneumocystis carinii pneumonia (PCP). 89 episodes of PCP were recorded in 75 patients. 63 of the 75 patients (84%) with a first episode of PCP were discharged. Of 72 patients wit
Lidman C; Ortqvist A; Lundbergh P; Julander I; Bergdahl S; Department of Infectious Diseases, Roslagstull Hospital,; Stockholm, Sweden.
In 33 consecutive AIDS patients with a first episode of Pneumocystis carinii pneumonia (PCP) we evaluated treatment, outcome, recurrence rate and pyrimethamine as chemoprophylaxis in a 1-year follow-up. Only 2 patients had a CD4 lymphocyte cell count greater than 0.2 X 10(9)/l. Trimethoprim-sulfamethoxazole (TMP-SMX)
39 persons with an incidentally discovered seroconversion from HIV antibody negative (Ab-) to antibody positive (Ab+) state as measured by an enzyme-linked immunosorbent assay (ELISA) were investigated for the presence of (1) HIV antigen (Ag) and (2) immunoblotting test (IBT) Ab in serum samples collected within the y
Morfeldt-Manson L; Julander I; Nilsson B; Department of Infectious Diseases, Roslagstull Hospital,; Stockholm, Sweden.
In a prospective longitudinal study of 89 men with HIV infection and persistent generalized lymphadenopathy (PGL) we tried to find clinical signs predictive of development to AIDS/opportunistic infection (OI). The mean observation time was 47 months. 27 patients (30%) developed AIDS/OI after a mean of 37 months. The e
The occurrence of visceral leishmaniasis is rare in Switzerland . We discovered this disturbance in a patient while on immunosuppressive medication for mycosis fungoides. Untreated visceral leishmaniasis has a high mortality. It can be expected that more cases will be observed
Volinn IJ; Department of Physiological Nursing, University of Washington,; Seattle 98195.
It is demonstrated how definitions can determine social consequences of impairment and disability. A comparison between leprosy and AIDS provides the basis for the discussion. The United States is the geographic and political arena under consideration. Issues of classification as STD (
Salud Publica Mex. 1989 Jul-Aug;31(4):536-40. Unique Identifier : AIDSLINE MED/90069755
Cruz-Lopez A; Cortes-Riveroll R; Valerdi-Minor G; Gonzalez E
The use of a fixing solution (FAF) to preserve parasite specimens in routine coproparasitoscopy is considered in this paper as an essential tool in surveys and field work aimed at diagnosing intestinal parasitic disease. It increases the reliability of the analysis procedure when the samples have to be transported ove
Mangos JA; Doran T; Aranda-Naranjo B; Rodriguez-Escobar Y; Scott A
The current epidemic of HIV infection/AIDS initially limited to homosexual males appears to be spreading through heterosexual transmission and intravenous drug abuse. Infants, children, and adolescents are affected. We examine the modes of transmission of HIV infection in this population and the impact the spreading o
Tidsskr Nor Laegeforen. 1989 Oct 20;109(29):3032-4. Unique Identifier : AIDSLINE MED/90070028
Skogstad M; Fossum S
In our opinion, screening of women seeking abortion and pregnant women does not benefit the work of HIV-prevention. Of the 115,600 tested from September 1987 to December 1988 in Norway , four new and HIV-positive and 92 false positive women were diagnosed. From the time screening st
The authors observed high incidence (100% among citizens of the USSR) and intensity of caries in 47 patients with diagnosed acquired HIV infection in the stage of symptom-free course and AIDS. In 2 persons out of 9 in symptom-free course of HIV infection an increase of mental lymph nodes has been observed. Significant
West J Med. 1989 Oct;151(4):410-3. Unique Identifier : AIDSLINE MED/90070671
Dixon AC; Yanagihara ET; Kwock DW; Nakamura JM
Concomitant strongyloidiasis and human T-cell lymphotropic virus type I (HTLV-I) infection has been reported from areas in Japan where both organisms are endemic. We present four cases of concomitant infection with these organisms from an area that is not endemic for Strongyloides s
West J Med. 1989 Oct;151(4):467-71. Unique Identifier : AIDSLINE MED/90070681
Seidman RL; Williams SJ; Mortensen LM
The economic cost of the acquired immunodeficiency syndrome (AIDS) in San Diego County, California, is forecast to increase from $103 million in 1986 to between $502 and $743 million in 1991, rising at a minimum average annual rate of 30% after adjusting for inflation. A greater emphasis on outpatient care and the use
Wis Med J. 1989 Sep;88(9):10-2. Unique Identifier : AIDSLINE MED/90070772
Meier PR; Baldauf MC
The incidence of infection by the human immunodeficiency virus (HIV) among pregnant women in north central Wisconsin is unknown. We devised and used an anonymous screening protocol to determine both the incidence of HIV infection and the rate of infection spread in this population. Our data demonstrate an extremely lo
Antibody spectra to individual proteins of human immunodeficiency virus (HIV) in 74 seropositive serum samples collected in the USSR and 65 serum samples collected in Britain were studied by immunoblotting techniques. Most of the sera belonged to clinically healthy persons, some of the sera collected in Britain contai
Sera from 5,705 persons were tested for antibodies to human T-cell leukemia virus type 1 (HTLV-I) by gelatin particle agglutination test (PA) and enzyme immunoassay (EIA) as screening methods, and the antibodies were confirmed by indirect immunofluorescence assay (IF) and Western blotting method (WB). The antibodies w
Biggar RJ; Pahwa S; Minkoff H; Mendes H; Willoughby A; Landesman S; Goedert JJ; Viral Epidemiology Section, National Cancer Institute, Bethesda,; MD 20892.
One hundred two pregnant women at high risk of infection with the human immunodeficiency virus (62 who were drug abusers and 40 of Haitian origin) were prospectively examined for immunologic changes during and after pregnancy. Among the 63 human immunodeficiency virus-negative women, levels of CD4+ (helper) cells fell
Lorentz A; Schipplick M; Gmehlin U; Osswald PM; Winter M; Institut fur Anaesthesiologie und Operative Intensivmedizin,; Universitat Heidelberg.
Transfusion of homologous blood components is associated with immunological (incompatibility, alloimmunization, immunosuppression) and infectious risks (hepatitis, cytomegalovirus , HIV and other agents). Endoprosthetic surgery of the hip and knee frequently requires transfusion. Pr
Drew RH; Weller S; Gallis HA; Walmer KA; Bartlett JA; Blum MR; Division of Infectious Diseases, Duke University Medical Center,; Durham, North Carolina 27710.
The objectives of this open-labeled, multiple-dose, three-way-crossover trial were to evaluate the safety and tolerance of zidovudine (Retrovir) oral syrup and to assess the bioequivalence of this formulation relative to zidovudine solution and capsule formulations in human immunodeficiency virus-infected patients. Ov
Pedersen U; Hansen IM; Bottzauw J; ENT Department, University Hospital, Aarhus, Denmark.
Fiberoptic bronchoscopy was carried out in 17 consecutive AIDS patients with suspected opportunistic infections. A total number of 23 bronchoscopies were performed and a comparison was made about the effectiveness of the available diagnostic techniques, which included bronchoalveolar lavage, transbronchial lung biopsy
Biochem Biophys Res Commun. 1989 Nov 15;164(3):1086-92. Unique Identifier : AIDSLINE MED/90073632
Swapna GV; Jagannadh B; Gurjar MK; Kunwar AC; Indian Institute of Chemical Technology, Hyderabad.
1H and 13C NMR study of 3 -azido-2 ,3 -dideoxyribosylthymine ( AZT ), an inhibitor of HIV (human immunodeficiency virus) replication, has been undertaken. Modified Karplus relations have been used to obtain the molecular structure from the indirect coup
Biochem Biophys Res Commun. 1989 Nov 15;164(3):1190-7. Unique Identifier : AIDSLINE MED/90073647
Balzarini J; Van Aerschot A; Herdewijn P; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
2 ,3 -Didehydro-2 ,3 -dideoxy-5-chlorocytidine (D4CC) is, in contrast with 2 ,3 -dideoxy-5-chlorocytidine (ddClCyd) and 2 ,3 -didehydro-2 ,3 -dideoxy-5-chlorouridine (D4CU), a potent and selective inhibitor of the replication of human immunodeficiency virus (HIV) types 1 and 2, simian immunodeficiency virus (SIV) and
Biochem Biophys Res Commun. 1989 Nov 30;165(1):401-7. Unique Identifier : AIDSLINE MED/90073742
Gogu SR; Beckman BS; Rangan SR; Agrawal KC; Department of Pharmacology, Tulane University School of Medicine,; New Orleans, LA.
Antiviral activity and bone marrow toxicity of 3 -azido-3 deoxythymidine (Zidovudine; AZT ) was evaluated in the presence of alpha-D-tocopherol acid succinate (ATS) in the MT4 cell line and in murine hematopoietic progenitor cells, respectively. At var
AIDS Res Hum Retroviruses. 1989 Oct;5(5):475-7. Unique Identifier : AIDSLINE MED/90074393
Goudsmit J; Dekker JT; Boucher CA; Smit L; De Ronde A; Debouck C; Barin F; Human Retrovirus Laboratory, Academic Medical Center, Amsterdam,; The Netherlands.
AIDS Res Hum Retroviruses. 1989 Oct;5(5):507-16. Unique Identifier : AIDSLINE MED/90074397
Hasler JM; Weighous TF; Pitts TW; Evans DB; Sharma SK; Tarpley WG; Division of Cancer and Infectious Diseases Research, Upjohn; Company, Kalamazoo, MI 49001.
We constructed a human immunodeficiency virus (HIV) trans-activator cDNA (tat) encoding the N-terminal 76 amino acids of the viral trans-activator followed by two additional amino acids (val and pro). This cDNA encoded a functional trans-activator (TAT) as shown by cotransfection into murine cells with a HIV promoter-
AIDS Res Hum Retroviruses. 1989 Oct;5(5):517-23. Unique Identifier : AIDSLINE MED/90074398
Lee FK; Nahmias AJ; Lowery S; Nesheim S; Reef S; Thompson S; Oleske J; Vahlne A; Czerkinsky C; Emory University School of Medicine, Atlanta, GA.
A new approach to detect and enumerate HIV-specific antibody-secreting cells (ASC) in the peripheral blood was developed using the enzyme-linked immunospot (ELISPOT) methodology. ASC to an HIV envelope recombinant protein were demonstrated in 75% of 16 adults and 72% of 21 children with untreated AIDS or ARC and in 63
AIDS Res Hum Retroviruses. 1989 Oct;5(5):525-33. Unique Identifier : AIDSLINE MED/90074399
Bottiger B; Karlsson A; Andreasson PA; Naucler A; Costa CM; Biberfeld G; Department of Immunology, National Bacteriological Laboratory,; Stockholm, Sweden.
A total of 57 HIV-1 antibody-positive sera and 43 HIV-2 antibody-positive sera were all tested for neutralizing capacity against two HIV-1 isolates (HTLV-IIIB and HTLV-IIIRF) and two HIV-2 isolates (SBL-6669 and SBL-K135). SBL-K135 is a new HIV-2 isolate obtained from a patient with clinical AIDS from
AIDS Res Hum Retroviruses. 1989 Oct;5(5):541-50. Unique Identifier : AIDSLINE MED/90074401
Agarwal RP; Busso ME; Mian AM; Resnick L; Department of Oncology, University of Miami School of Medicine,; FL 33101.
The uptake of 2 ,3 -dideoxyadenosine was examined in a human immunodeficiency virus (HIV) infected and uninfected T cell line (H9 cells), a B cell line (Namalwa), and in normal peripheral blood mononuclear cells. After a 10-minute incubation at ambient temperature, the intracellular 2 ,3 -dideoxyadenosine-derived radi
AIDS Res Hum Retroviruses. 1989 Oct;5(5):551-4. Unique Identifier : AIDSLINE MED/90074402
Re MC; Tommaseo M; Furlini G; La Placa M; Institute of Microbiology, University of Bologna, Italy.
An unusually high prevalence (45%) of serum antibodies to human T cell leukemia virus type I (or to an antigenically related virus) in comparison with that observed against other viral pathogens (human immunodeficiency virus type 1, herpes simplex virus, human cytomegalovirus , vari
Aymard JP; Ferry R; Janot C; Schooneman F; Legras B; May T; Streiff F; Regional Blood Transfusion and Haematology Centre, Nancy, France.
HPA-23 is a competitive inhibitor of the RNA-dependent DNA polymerase (reverse transcriptase) of the human immunodeficiency virus (HIV). It may therefore potentially benefit patients with HIV infection. This study aimed at defining the haematopoietic toxicity of this drug and particularly its effects on the normal hum
Fuchs D; Milstien S; Kramer A; Reibnegger G; Werner ER; Goedert JJ; Kaufman S; Wachter H; Institute of Medical Chemistry and Biochemistry, University of; Innsbruck, Austria.
Neopterin measurements are especially useful as an early marker in (e.g.) allograft rejections and in patients infected with human immunodeficiency virus type 1 (HIV-1). An increased concentration of total neopterins (neopterin + dihydroneopterin) is also a significant marker in patients with HIV-1 infection. In this
Kaposi s sarcoma is seen in one of several clinical settings. Before the recognition of the acquired immune deficiency syndrome (AIDS) in the early 1980s, the most frequent presentation of Kaposi s sarcoma in the UK was the so-called classical form of the disease. The most common form of Kaposi s sarcoma in this cou
Fosse E; Svennevig JL; Pillgram-Larsen J; Gerner T; Ulstrup J; Department of Surgery, Ulleval Hospital, Oslo, Norway.
Of a total number of 643 injured patients admitted during 1986 and 1987, 113 were tested for antibodies against the human immunodeficiency virus (HIV) and hepatitis B surface antigen HBsAg and the concentration of hepatitis B surface antibodies (HBsAb) was determined. Nine patients were HIV positive while HBsAg was de
Wescott WB; Werksman L; Dental Service, Veterans Administration Medical Center, San; Francisco 94121.
All health care providers must become increasingly aware of the early signs and symptoms of AIDS as KS frequently appears in the head, neck, and oral regions. Dentists are responsible for recognizing these lesions, especially the early lesions, providing dental treatment as appropriate, and for referring patients with
The transmissibility of HIV infection through blood transfusion has resulted in many altered ideas about blood transfusion and a re-evaluation of the indications for transfusion. Because of the risks of transfusion, the increased emphasis on proper use of hospital resources and the increasing number of managed care pa
Bowie C; Ford N; Somerset Health Authority, Taunton.
A survey of 16-21 year old people in Somerset was undertaken to find out about their sexual behaviour prior to mounting a local education campaign on AIDS. A representative sample of 400 people, using quota sampling in 40 randomly selected electoral wards, completed a schedule structured part self administered questio
Martin RA; Williams T; Montalto N; Department of Family Medicine, College of Medicine, Ohio State; University, Columbus 43210.
This report is a description of two Ohio cases of acquired immunodeficiency syndrome (AIDS) and disseminated histoplasmosis, with discussion of diagnosis and treatment of this combination. The patient in case 1 developed disseminated histoplasmosis as the first significant symptomatic medical condition of his life. Th
Ottomanelli G; Heller S; Bihari B; Kramer T; Juni S; State University of New York, Health Science Center, Brooklyn; 11203.
The Defense Mechanism Inventory (DMI) and The Risk Behavior Inventory (RBI) were administered to substance abusers hospitalized on a drug detoxification service. The groups were categorized on the basis of self-reported IV versus non-IV substance abuse. Significant between-group differences were obtained on the DMI an
Itoyama T; Sadamori N; Tokunaga S; Sasagawa I; Nakamura H; Yao E; Jubashi T; Yamada Y; Ikeda S; Ichimaru M
The chromosome 14q11 anomaly has been reported to be specific to adult T-cell leukemia (ATL) and this anomaly has also been confirmed in preleukemic state of ATL (pre-ATL) patients though the frequency is low. In an attempt to clarify if the same chromosome aberrations could be found also at the stage of HTLV-I carrie
Nakasone T; Masuda M; Arakaki H; Shimoji T; Araki K; Mimura G
A 60-year-old man born in Okinawa was admitted to our hospital because of epigastralgia. Physical examination revealed general lymphadenopathy, mild hepatomegaly and skin eruption. The peripheral blood leukocyte count was 168,600/microliters, with 93% abnormal lymphocytes showing convoluted or lobulated nuclei. Anti H
The whole world is divided into 3 groups by the magnitude of tuberculosis problem: namely, developed countries in which tuberculosis is already a minor health problem and continues to decline; NIES and some oil-producing countries in which tuberculosis started to decline significantly; and most developing countries in
Med Care. 1989 Dec;27(12):1085-98. Unique Identifier : AIDSLINE MED/90080984
Kelly JV; Ball JK; Turner BJ; National Center for Health Services Research and Health Care; Technology Assessment (NCHSR), Department of Health and Human; Services, Rockville, Maryland 20857.
This study uses the Severity Classification for AIDS Hospitalizations to examine and contrast the duration and costs of hospitalizations among 6,142 AIDS discharges from New York hospitals during 1985. Multivariate regression analyses of resource-use differences suggest that more severely ill AIDS patients have consid
Med Lab Sci. 1989 Apr;46(2):135-40. Unique Identifier : AIDSLINE MED/90081232
Barbara JA; Salker R; Challis P; Contreras M
Modification of a commercial gelatin particle agglutination assay for anti-HIV reduces the test time to 30 min, increases the sensitivity sevenfold without any prozoning, and maintains specificity while cutting the cost of the test by 90%. The modification involves a tenfold dilution of the gelatin particles, which ar
Med Educ. 1989 Nov;23(6):534-7. Unique Identifier : AIDSLINE MED/90081463
Russell JG; Smithurst BA; Department of Dental Surgery, University College, Cork, Republic; of Ireland.
A plea is made for a significant input on AIDS to the dental undergraduate curriculum by medical teachers. The suspicion is that in some schools the teaching of medicine to dental students is not treated seriously. Figures are quoted depicting the worldwide spread of AIDS. The risk of dentists acquiring HIV in the hea
Bennett G; Chapman S; Bray F; Department of Community Medicine, Westmead Hospital, NSW.
One hundred and seventy-six men who had engaged in sexual activity with other men in the past six months were interviewed, in the western area of Sydney, about their sexual activities and knowledge as related to the acquired immunodeficiency syndrome (AIDS). Comparisons were made between men who had frequented beats (
Bennett G; Chapman S; Bray F; Department of Community Medicine, Westmead Hospital, NSW.
Fifty-four actively bisexual men with recent sexual experiences with both men and women were interviewed as part of a wider study of 176 homosexual men, many of whom frequented beats (public toilets, parks and isolated roads where men meet for homosexual encounters). Forty-six per cent of the bisexual men were engagin
Tindall B; Swanson C; Donovan B; Cooper DA; NHMRC Special Unit in AIDS Epidemiology and Clinical Research,; Surry Hills, NSW.
Between January 1, and October 31, 1987, 420 homosexual men who participated in a cohort study of infection with the human immunodeficiency virus (HIV) completed a questionnaire that examined their sexual practices during the previous six months. Of the subjects, 205 (48.8%) men were HIV-seropositive and 215 (51.2%) m
N Engl J Med. 1989 Dec 28;321(26):1791-6. Unique Identifier : AIDSLINE MED/90081778
Scott GB; Hutto C; Makuch RW; Mastrucci MT; O'Connor T; Mitchell CD; Trapido EJ; Parks WP; Department of Pediatrics, University of Miami School of Medicine,; Fla. 33101.
We describe our experience at Jackson Memorial Hospital in Miami, Florida, with 172 children who were given diagnoses of perinatally acquired infection with human immunodeficiency virus type 1 (HIV-1). The 146 mothers of the children acquired HIV-1 through heterosexual contact (69 percent), intravenous drug use (30 pe
Nature. 1989 Dec 21-28;342(6252):948-50. Unique Identifier : AIDSLINE GENBANK/X16109
Dietrich U; Adamski M; Kreutz R; Seipp A; Kuhnel H; Rubsamen-Waigmann H; Chemotherapeutisches Forschungsinstitut, Georg-Speyer-Haus,; Frankfurt, FRG.
It has been suggested that the human immunodeficiency virus type 2 (HIV-2) and the simian immunodeficiency virus from rhesus macaques (SIVmac) evolved from the sooty mangabey virus SIVsm (ref. 1). We now describe an HIV-2-related isolate, HIV-2-D205, from a healthy Ghanaian woman that is genetically equidistant to the
The Human Immunodeficiency Virus (HIV) epidemic raised the question of whether students should be required to provide nursing care for clients whose diagnosis for treatments may jeopardize students health. Policies and procedures are necessary to provide a framework of functioning for faculty and students when studen
AIDS surveillance data are used routinely to define the magnitude of the epidemic, project future case numbers, delineate risk behaviors, and to assist in health planning and resource allocation. The purposes of this study are: (1) to evaluate the effectiveness of the Ohio Department of Health (ODH) AIDS Surveillance
De BK; Srinivasan A; Retrovirus Diseases Branch Centers for Disease Control, Atlanta,; Georgia 30333.
To type the specific human T-lymphotropic virus (HTLV) coinfection in acquired immunodeficiency syndrome (AIDS) patients, we have utilized the polymerase chain reaction technique. The primer pairs employed for HTLV-I and HTLV-II are derived from pol and env regions and gag region for human immunodeficiency virus (HIV)
Alpha interferon has been extensively studied in the treatment of the epidemic form of Kaposi s sarcoma (KS) common in the acquired immunodeficiency syndrome (AIDS). Its safety and efficacy against KS have been well documented, with objective tumor responses seen in 25%-50% of cases. In a number of large uncontrolled
Practitioner. 1989 Jun 8;233(1470):851, 853-4. Unique Identifier : AIDSLINE MED/90082955
Lockie C
Unfamiliar physical conditions and pathogens are encountered during foreign travel. Ill effects can be avoided by careful planning and this is particularly important for the elderly, children and for travellers with chronic medical problems.
Practitioner. 1989 Jun 22;233(1471):942-3. Unique Identifier : AIDSLINE MED/90082974
Gallagher M
General practice provides many opportunities for health education and for giving advice that may help prevent the spread of HIV infection. This article looks at some of the opportunities and problems.
If nurses are to care for people with AIDS properly and inform the public effectively, it is important for them to explore their feelings about the disease and resolve any prejudices they may have.
Orefice G; Carrieri PB; Chirianni A; Tullio-Cataldo P; Farace A; Gentile S; Troisi E; Striano S; Istituto per lo Studio delle Malattie del Sistema Nervoso, 2a; Facolta di Medicina e Chirurgia, Napoli.
Cerebral toxoplasmosis is the most common cause of focal CNS disease complicating AIDS and may afflict 10% to 33% of such patients. We present the clinical, neuroradiological and immunological findings in 5 cases with cerebral toxoplasmosis complicating the acquired immune deficiency syndrome. All patients had focal n
Singapore Med J. 1989 Feb;30(1):28-31. Unique Identifier : AIDSLINE MED/90084583
Chew SK; Monteiro EH
The Acquired Immunodeficiency Syndrome (AIDS) is caused by a retrovirus, the Human Immunodeficiency Virus (HIV). As at 30 April 1988, there were 22 infected individuals in Singapore , of which 4 had AIDS. A comprehensive retrospective study was carried out to establish the clinic
Immune thrombocytopenic purpura may be the sole clinical manifestation of HIV infection. Results of the treatment of 6 patients with spontaneous bleeding due to severe thrombocytopenia, are presented. In all patients immune thrombocytopenic purpura was the only clinical manifestation of HIV infection. Four of them wer
Sex Transm Dis. 1989 Oct-Dec;16(4):178-83. Unique Identifier : AIDSLINE MED/90084824
Wasser SC; Aral SO; Reed DS; Bowen GS; Division of Sexually Transmitted Diseases, Centers for Disease; Control, Atlanta, Georgia 30333.
Four hundred fifty-five women in family-planning and sexually transmitted disease (STD) clinics were surveyed to determine the degree of participation in behaviors known to be associated with increased risk of human immunodeficiency virus (HIV) infection. A previous history of STD (20%) and multiple sexual partners (7
Sex Transm Dis. 1989 Oct-Dec;16(4):184-9. Unique Identifier : AIDSLINE MED/90084825
Cannon RO; Schmid GP; Moore PS; Pappaioanou M; Centers for Disease Control, Atlanta, GA.
We reviewed published and unpublished studies on seroprevalence of HIV antibody in persons attending sexually transmitted disease (STD) clinics in the United States from 1985 through 1987. We identified 23 studies from 16 states; nine studies determined risk factors for HIV. Overall, 8
The leadership of the 70th Texas Legislature (1987) created the Legislative Task Force on AIDS to study the impact of AIDS in Texas and to recommend to the 71st Legislature (1989) public policies needed to reduce the impact of AIDS in Texas. The task force held numerous public hearings and received testimony from witn
Mangos JA; Doran T; Aranda-Naranjo B; Rodriguez-Escobar Y; Scott A
HIV infection/AIDS in infants and children under the age of 13 years expresses itself clinically so differently from the same infection in adults that a separate classification of the symptomatology has been adopted. Recurrent bacterial infections, as well as various opportunistic infections predominate, and while Kap
Tidsskr Nor Laegeforen. 1989 Nov 20;109(32):3341-3. Unique Identifier : AIDSLINE MED/90085227
Sundet JM; Magnus P; Kvalem IL; Bakketeig LS
In a questionnaire survey on sexual behaviour, a random sample of 10,000 Norwegians aged 18 through 60 were asked about use of condoms during their last intercourse. The response rate was 62.7%. Except as regards level of education, the response group was fairly representative of the population with respect to socio-d
Tidsskr Nor Laegeforen. 1989 Nov 20;109(32):3345-8. Unique Identifier : AIDSLINE MED/90085228
Diseth TH
Limiting the use of contaminated syringes is an important step in the battle against hepatitis B and HIV epidemics. In 1987 a project, the first of its kind, was started in Larvik and the county of Vestfold in Norway . Syringe dispensers were put up in order to ensure that drug addi
Kuntz BM; Bruster HT; Institute of Bloodcoagulation & Transfusionmedicine,; Heinrich-Heine-Universitat, Dusseldorf, FRG.
In a 5-year-study of HLA-phenotypes in 411 HIV-1-infected individuals, a progressive decrease of the formerly elevated frequency of HLA-DR5 has been observed. HLA-DR3 seems to have a protective effect. These results are discussed with respect to the mimicry-hypothesis of HLA and disease associations. Further prelimina
Ugeskr Laeger. 1989 Nov 13;151(46):3059-62. Unique Identifier : AIDSLINE MED/90085455
Schmidt KW; Kroon S; Petersen CS; Worm AM
With the object of describing how their own health is experienced, the social circumstances and sexual behaviour in anti-HIV-positive homosexual and bisexual men, an anonymous questionnaire to be completed by the recipient was distributed in 1987 in connection with a placebo controlled investigation to assess the valu
Ugeskr Laeger. 1989 Nov 20;151(47):3155-7. Unique Identifier : AIDSLINE MED/90085475
Mathiesen O; Brodthagen UA; Edvardsen I; Grunnet N
We performed a questionnaire study among 413 consecutive voluntary unpaid blood donors being bled for the first time. About 50% were aged below 26 years, 93% were employed or students, and 50% of the donors came from families with other blood donors. The motives to donate blood were investigated. As motives we found:
Hu W; Vander Heyden N; Ratner L; Department of Medicine, Washington University, St. Louis,; Missouri 63110.
To investigate the function of vpx, a gene in HIV-2 and SIV, but not in HIV-1, three site-directed mutants (pMX) were constructed from a functional proviral HIV-2 plasmid clone (pSE). Transfection of COS-1 cells with all three mutants as well as pSE gave rise to equivalent amounts of virus. Each virus could be passage
The number of patients with AIDS is still growing rapidly. The identification of opportunistic diseases requires special skills in microbiology. The methods for identifying and distinguishing between opportunistic fungi and pneumocystis carinii are introduced.
Lepage P; Van de Perre P; Nsengumuremyi F; Van Goethem C; Bogaerts J; Hitimana DG; Department of Paediatrics, and Center Hospitalier de Kigali,; Rwanda.
In Rwanda , both HIV infection and bacteraemia represent major health problems among paediatric populations. We carried out of prospective study of determine if bacteraemia is a marker of HIV infection among ambulatory and hospitalized Rwandese children. All children presenting at t
Labrune P; Blanche S; Catherine N; Maier-Redelsperger M; Delfraissy JF; Tchernia G; Service de Pediatrie Generale, Hopital Antoine Beclere,; Clamart, France.
Severe thrombocytopenia was the initial manifestation of human immunodeficiency virus infections in 5 infants under 15 months of age. In only 2/5 cases maternal seropositivity was previously known while in the other 3 it was discovered after onset of the infants thrombocytopenia. One infant died, due to intracranial
Between May 1987 and November 1988 we performed the human immunodeficiency virus (HIV) antibody serological test on 586 patients of the Urology and Nephrology Services, and it was positive in 14 cases. Of these, 6 came on account of urological pathology: bilateral cryptorchidism, giant condylomata acuminata, acute pye
Am J Drug Alcohol Abuse. 1989;15(4):443-61. Unique Identifier : AIDSLINE MED/90086708
Westermeyer J; Seppala M; Gasow S; Carlson G; Department of Psychiatry, University of Minnesota, Minneapolis; 55455.
Little has been written about the treatment of substance use disorders among seropositive HIV patients or high-risk seronegative substance abusers. Demographic and clinical characteristics, along with treatment issues, were examined based on experience with 18 patients in a substance abuse program in a university medi
Am J Gastroenterol. 1989 Dec;84(12):1521-4. Unique Identifier : AIDSLINE MED/90086719
Gray JR; Rabeneck L; Department of Medicine, University of British Columbia, St.; Paul's Hospital, Vancouver, Canada.
This paper will describe a case series of 35 AIDS patients with infection of the gastrointestinal (GI) tract with Mycobacterium avium-intracellulare (MAIC). Thirty-five homosexual men with a mean age of 35 yr and a mean duration of AIDS of 7.7 months prior to the diagnosis of MAIC were investigated to determine the ex
Am J Gastroenterol. 1989 Dec;84(12):1525-31. Unique Identifier : AIDSLINE MED/90086720
Comer GM; Mukherjee S; Scholes JV; Holness LG; Clain DJ; Department of Medicine, Harlem Hospital Center, New York, NY.
A retrospective review of 48 liver biopsies in 34 patients with acquired immune deficiency syndrome (AIDS) and 10 patients with AIDS-related complex (ARC) was performed at Harlem Hospital Center to assess the diagnostic yield of liver biopsies in this distinct patient population. Among the patients, 93.2% were black a
Am J Med Sci. 1989 Dec;298(6):407-9. Unique Identifier : AIDSLINE MED/90086865
Ibanez HE; Ibanez MA; Department of Medicine, San Juan Veterans Administration; Hospital, Puerto Rico.
The clinical and histopathological features and the therapeutic response of a pustular eruption occurring in a homosexual man with Acquired Immune Deficiency Syndrome (AIDS) is reported. The rare cutaneous presentation consisted of mostly circumscribed, tender, tense pustules, associated with erythema, confined to the
Ann Med Interne (Paris). 1989;140(5):399-403. Unique Identifier : AIDSLINE MED/90087535
Nguyen Q; Laurent M; Bouchon JP; Lons Danic D; Vachon F; Bletry O; Frottier J; Congy F; Bousser MG; Leport C; et al; Unite d'Immunopathologie Clinique, Hopital Henri-Mondor,; Creteil.
If geriatric AIDS is defined as the occurrence of this disease in individuals over 60 years old, it represents about 5% of the cases reported to the Direction Generale de la Sante by the end of 1988. We retrospectively analyzed 22 clinical cases of geriatric AIDS observed between 1985 and 1987, i.e. 21% of the cases r
Ann Med Interne (Paris). 1989;140(5):405-7. Unique Identifier : AIDSLINE MED/90087536
Taillan B; Roul C; Fuzibet JG; Vinti H; Pesce A; Bayle J; Cassuto JP; Dujardin P; Service de Medecine Interne I, Hopital de Cimiez, Nice.
One hundred and fifty-seven HIV seropositive patients were included in a prospective study of coagulation parameters. Activated partial thromboplastin time, prothrombin time, thrombin time and specific factor assays of the intrinsic pathway were performed using standard techniques. The tissue thromboplastin inhibition
De Rienzo B; Mongiardo N; Pellegrino F; Coppini M; Lami G; Zanchetta G; Borghi V; Cocchi I; Squadrini F; Giannetti A; Department of Infectious and Tropical Diseases, University of; Modena, Italy.
The transmission of the human immunodeficiency virus (HIV) was studied in 647 subjects who presented no apparent risk factors for the infection other than having had promiscuous heterosexual relations, heterosexual relations with people with an elevated risk of infection, or heterosexual relations with people infected
Psychiatric-mental health nurses are taking a leadership role in the human immunodeficiency virus epidemic. This article details activities, developed through federally-supported acquired immune deficiency syndrome (AIDS) projects, which are designed to meet the mental health needs of health professionals who work int
Linn LS; Spiegel JS; Mathews WC; Leake B; Lien R; Brooks S; Department of Medicine, UCLA 90024-1685.
We studied the sociodemographic characteristics, knowledge, and beliefs about acquired immunodeficiency syndrome transmission and sexual practices of 823 gay or bisexual men seeking primary care. During the previous 2 months, 64% had engaged in at least one sexual behavior considered unsafe. These patients compared wi
Kone I; Michel G; Thuret I; Siccardi F; Vallee D; Juhan I; Perrimond H; Service d'Hematologie Pediatrique, Groupe Hospitalier de la; Timone, Marsielle.
We report the cases of 38 children with transfusion-associated HIV infection: 18 hemophiliacs and 2 patients with Von Willebrand disease, 6 with hemoglobinopathies, 8 with malignant diseases or aplastic anemia, 2 transfused during neonatal period and 2 during a surgical operation. Two groups with a different prognosis
Costa CM; Salgueiro MR; Carton H; Do Vale OC; De Arruda AM; Department of Physiology, Federal University of Ceara, Brazil.
Ten possible cases of tropical spastic paraparesis (TSP) in Northeastern Brazil (Ceara) are presented. They show the typical symptoms and signs of TSP consisting of weakness of the lower limbs, spastic gait, hyperreflexia, bladder dysfunction and variable signs of posterior columns
Eighteen patients with DPB and 15 with IIP were studied on the relationship between the diseases and ATL. Anti-ATL antigen (ATLA) antibody and its related reactions were examined using immunofluorescence and Western blotting techniques. Five of 18 DPB patients (28%) were anti-ATLA antibody positive, and were diagnosed
Bettaieb A; Oksenhendler E; Fromont P; Duedari N; Bierling P; Centre Departemental de Transfusion Sanguine du Val de Marne,; Hopital Henri Mondor, Creteil, France.
Serum antiplatelet IgG and platelet-associated IgG (PAIgG) were studied in 68 AIDS-free human immunodeficiency virus (HIV)-infected patients with severe immunologic thrombocytopenic purpura (ITP), for the presence of platelet autoantibodies. Serum IgG with antiplatelet activity was found in 72% of the sera. However, t
Fan FS; Lin DL; Yeh HM; Chen MS; Su JL; Lin SH; Tzeng CH; Chuang MW; Liu JH; Hsieh RK; et al
Nine hundred and sixty five serum samples of blood donors from the blood bank of Veterans General Hospital Taipei were screened for antibodies to human T-cell leukemia virus type I (HTLV-I) by different methods. Adult T-cell Leukemia cell lines MT-1, MT-2, KH-2 and MT-2 stimulated by phorbol 12-myristate 13-acetate (P
Curr Top Microbiol Immunol. 1989;148:1-42. Unique Identifier : AIDSLINE MED/90059388
Kabat D
Friend virus clearly provides an important model for understanding the molecular biology of cancer. Moreover, the most important aspects of the erythroleukemia can be caused by a single SFFV infection in the absence of any helper virus. The SFFV env gene encodes a membrane glycoprotein, gp55. This glycoprotein, when e
EMBO J. 1989 Sep;8(9):2653-60. Unique Identifier : AIDSLINE MED/90060026
Delchambre M; Gheysen D; Thines D; Thiriart C; Jacobs E; Verdin E; Horth M; Burny A; Bex F; Department of Molecular Biology, University of Brussels, Belgium.
To examine the potential role of the GAG precursor polyprotein in morphogenesis and assembly of the simian immunodeficiency virus (SIV), we have expressed the gag gene of SIVMac using a baculovirus expression vector. Infection of insect cells with recombinant virus containing the entire gag gene results in high expres
Raoult D; Hechemy KE; Baranton G; Centre National de Reference des Rickettsioses, Centre; Hospitalier Universitaire la Timone, Marseille, France.
We have studied the cross-reaction with Borrelia burgdorferi of sera positive for leptospirosis, syphilis, or human immunodeficiency virus by using the microimmunofluorescence test (micro-IF). The percentage of sera reactive in the micro-IF before absorption varied from 7 to 37% and was reduced to 3 to 8% after absorp
Vasudevachari MB; Uffelman K; Pierce PF; Lane HC; Salzman NP; Department of Microbiology, Georgetown University School of; Medicine, Washington, D.C. 20007.
A passive hemagglutination test (PHA) for detecting human immunodeficiency virus type 1 antibodies in serum samples by using envelope glycoprotein (gp160)-coupled sheep erythrocytes was described earlier (M.B. Vasudevachari, K. U. Uffelman, T.C. Mast, R.L. Dewar, V. Natarajan, H.C. Lane, and N.P. Salzman, J. Clin. Mic
Chadwick EG; Yogev R; Kwok S; Sninsky JJ; Kellogg DE; Wolinsky SM; Department of Pediatrics, Northwestern University Medical School,; Chicago, Illinois.
The presence of the human immunodeficiency virus type 1 (HIV) provirus was assessed in peripheral blood mononuclear cells (PBMCs) from 27 offspring of HIV-infected mothers, 12 of these mothers, and 4 HIV-uninfected mother-infant control pairs. Enzymatic amplification of specific conserved regions of the gag and env ge
Ganz WI; Serafini AN; Department of Radiology, University of Miami School of Medicine,; Florida.
This paper is a review of (a) the pathophysiology of the autoimmune deficiency syndrome (AIDS), and (b) the diagnostic procedures nuclear medicine has to evaluate human immunodeficiency virus related disorders. This article is organized in an organ system approach to AIDS pathology. The application of [67Ga]citrate, 1
Yee JM; Raghavendra BN; Horii SC; Ambrosino M; Department of Radiology, NYU Medical Center, NY 10016.
Sonographic examination of the abdomen was performed in 155 patients with clinical diagnosis of AIDS. Approximately one half of the patients had hyperechoic (fatty) liver and splenomegaly. About one third of the patients had lymphadenopathy and hyperechoic kidneys. Intravenous drug abusers were more likely to have ren
Baier M; Werner A; Cichutek K; Garber C; Muller C; Kraus G; Ferdinand FJ; Hartung S; Papas TS; Kurth R; Paul-Ehrlich-Institut, Langen, Federal Republic of Germany.
Simian immunodeficiency viruses have been isolated from African green monkeys originating from Ethiopia . A molecular clone, termed SIVagm3, was found to be highly divergent from SIVagmTYO-1 in terms of its restriction map and partial nucleotide sequence. A premature stop codon pr
Valensin PE; Zazzi M; Valassina M; Bianchi Bandinelli ML; Toti M; Almi P; Rubino M; Caruso A; Institute of Microbiology of the University, Siena, Italy.
Live-cell indirect immunofluorescence was used to detect HIV-associated antigens in fresh uncultured peripheral blood mononuclear cells from 29 HIV-seropositive subjects. Conventional fixed-cell immunofluorescence and live-cell immunofluorescence were run in parallel on each sample using monoclonal antibodies directed
Med Hypotheses. 1989 Aug;29(4):283-91. Unique Identifier : AIDSLINE MED/90066110
Ayre SG
The Human Immunodeficiency Virus (HIV) is the causative agent of AIDS and this has been found to be neurotropic. For this reason the development of an effective strategy for the delivery of antiviral drugs across the blood-brain barrier is of paramount importance in the treatment of HIV infection. There are insulin re
Koch CA; Moran M; Sadowski I; Pawson T; Division of Molecular and Development Biology, Mount Sinai; Hospital Research Institute, Toronto, Ontario, Canada.
A conserved noncatalytic domain SH2 (for src homology region 2) is located immediately N terminal to the kinase domains of all cytoplasmic protein-tyrosine kinases. We found that the wild-type v-fps SH2 domain stimulated the enzymatic activity of the adjacent kinase domain 10-fold and functioned as a powerful positive
Because of the known pathogenicity of Cryptococcus neoformans and of aspergilli depending on defined but different immunodeficiencies of the host, the evaluation of their simultaneous cultural detection in specimens of the respiratory tract of AIDS patients is of epidemiological, diagnostic, pathogenetic and therapeut
Fifty bone marrows from patients with AIDS were studied to identify the abnormalities related to marrow failure. Prominent reticulin fibrosis and increased atypical megakaryocytes were the major changes associated with the aberrant hematopoietic microenvironment.
Reeder JM; School of Nursing, University of Maryland, Baltimore.
Ethical dilemmas in perioperative nursing practice occur during all phases and in every practice setting. Awareness of commonly experienced dilemmas and understanding of a model available to analyze and resolve these dilemmas can benefit patients and perioperative nurses. Patients will benefit from nurse advocates who
Kramer EL; Sanger JJ; Nuclear Medicine Service, Memorial Sloan-Kettering Cancer Center,; New York, New York.
The challenge of the acquired immunodeficiency syndrome (AIDS) for nuclear medicine has been the early detection of related intrathoracic opportunistic infections, inflammatory conditions, and neoplasms. Gallium-67 citrate scanning has proved a sensitive test not only for Pneumocystis carinii pneumonia but for many of
Mitchell DM; Department of Medicine, St Mary's Hospital, London, U.K.
Since the first case of AIDS in the United Kingdom was described in 1981 (1), there have been up to October 1988, 1794 AIDS cases reported, of whom 965 are dead and 8794 individuals known to be Human Immunodeficiency Virus (HIV) seropositive (2). In fact the actual number of seropositi
Huraux JM; Ingrand D; Agut H; Devillechabrolle A; Lab. de Bacteriologie-Virologie, Groupe Hospitalier; Pitie-Salpetriere, Paris.
The advances achieved in our knowledge on the virus multiplication cycle and the challenge created by the advent of AIDS have resulted in a rational development of new antiviral agents. However, antiviral chemotherapy is hindered by several obstacles: (1) most antiviral drugs are cytotoxic, with the exception of
Teglbjaerg LL; Mathiesen LR; Soeberg B; Nielsen L; Thorsen B; Buhl M; Pedersen C; Bonnevie O; Nielsen C; Vestergaard BF; et al; Department of Infectious Diseases, Hvidovre Hospital, Copenhagen,; Denmark.
In 1987, a total of 138 Danish patients (94 AIDS and 44 ARC) received treatment with zidovudine, a total observation period of 572 treatment months. 15 AIDS and 1 ARC patient died after a median of 70 days (range 2-295). In the ARC group 4 patients developed AIDS (3 Pneumocystis carinii pneumonia, 1 Kaposi s sarcoma).
Leinikki P; Mattila E; Koistinen J; Leikola J; Kantanen ML; Brummer-Korvenkontio H; HIV-Laboratory, National Institute of Public Health, Helsinki,; Finland.
5,287 serum samples from 2 different sources in Finland , people possibly at risk and healthy blood donors, were tested for the presence of HTLV-I antibodies. No positive cases were found. The result suggests that this virus is not e
Science. 1989 Dec 1;246(4934):1149-52. Unique Identifier : AIDSLINE MED/90069585
Miller M; Schneider J; Sathyanarayana BK; Toth MV; Marshall GR; Clawson L; Selk L; Kent SB; Wlodawer A; NCI-Frederick Cancer Research Facility, BRI-Basic Research; Program, MD 21701.
The structure of a complex between a peptide inhibitor with the sequence N-acetyl-Thr-Ile-Nle-psi[CH2-NH]-Nle-Gln-Arg.amide (Nle, norleucine) with chemically synthesized HIV-1 (human immunodeficiency virus 1) protease was determined at 2.3 A resolution (R factor of 0.176). Despite the symmetric nature of the unligande
Recently the first report of zidovudine-resistant human immunodeficiency virus obtained from AIDS patients was published. Resistance to antiviral agents may result from single point mutations in the virus genome. Several mechanisms of resistance have already been elucidated at the biochemical level but the clinical si
Ugeskr Laeger. 1989 Oct 30;151(44):2870-3. Unique Identifier : AIDSLINE MED/90070314
Hansen PR
Chronic progressive polyneuropathy is frequently cryptogenic but occurs in association with monoclonal gammopathy. In cases of this type, a relatively mild, mainly axonal sensomotor neuropathy is frequently present and may be difficult to distinguish from carcinomatous neuropathy in malignant conditions without the pr
Ugeskr Laeger. 1989 Nov 6;151(45):2955-8. Unique Identifier : AIDSLINE MED/90070336
Jepsen OB; Strobaek S; Zimakoff J
In the world literature, 31 probable or certain cases of occupational HIV-infection among health staff have been described during a period of ten years from 1977. In 17 cases needle punctures had occurred while cuts or skin/mucosal exposure had occurred on 11 occasions. The predominant route of infection was thus perc
Ugeskr Laeger. 1989 Nov 6;151(45):2960-2. Unique Identifier : AIDSLINE MED/90070338
Hansen PB; Olsen NV
Beta-2-microglobulin (beta 2M) is a low-molecular protein which is filtered freely over the glomeruli. Under normal circumstances, more than 99.9% is resorbed in the proximal tubuli of the kidneys and is metabolized there. In renal disease with damage to this segment of the nephron, eg acute tubulo-interstitial nephro
Berlin L; Pincus JH; Department of Neurology, Yale University School of Medicine, New; Haven, Conn.
All cases of cryptococcal meningitis at Yale-New Haven (Conn) Hospital seen during a 4 1/2-year period were reviewed to calculate the rate of false-negative antigen test results and cultures preceding diagnosis. Of 13 patients, 9 were immunosuppressed and were diagnosed following the initial lumbar puncture, with both
Biochem Biophys Res Commun. 1989 Nov 15;164(3):955-60. Unique Identifier : AIDSLINE MED/90073685
Heimbach JC; Garsky VM; Michelson SR; Dixon RA; Sigal IS; Darke PL; Department of Molecular Biology, Merck Sharp and Dohme Research; Laboratories, West Point, PA 19486.
An inhibitor of the HIV-1 protease has been employed in the generation of a resin which allows the rapid purification of this enzyme. A peptide substrate analogue, H2N-Ser-Gln-Asn-(Phe-psi[CH2N]-Pro)-Ile-Val-Gln-OH, was coupled to agarose resin. The HIV-1 protease was expressed in E. coli and the supernatant from lyse
Tirelli U; Vaccher E; Rezza G; Barbui T; Bernasconi C; Cajozzo A; Cargnel A; de Lalla F; Dessalvi P; Fassio PG; et al; Division of Medical Oncology, Centro Di Riferimento Oncologico,; Aviano, Italy.
In an Italian cooperative study on AIDS and cancer a diagnosis of Hodgkin s disease was established in 36 HIV-positive patients. The series was characterized by a high proportion of drug abusers, a high proportion of mixed cellularity and lymphocytic depletion subtypes and short survival. It is still unclear if HIV in
AIDS Res Hum Retroviruses. 1989 Oct;5(5):495-506. Unique Identifier : AIDSLINE MED/90074396
Hammar L; Eriksson S; Morein B; Department of Veterinary Virology, Biomedical Center, Uppsala,; Sweden.
Recombinant glycoproteins derived from the HIV env gene are available and are under evaluation as antigens in vaccines against AIDS. The importance of the glycoconjugate structure for eliciting a protective immune response by these proteins is incompletely known. In this report we devise a method for the characterizat
Bailly D; Dervaux A; Servant D; Parquet PJ; Psychopathology and Alcohology Unit, University Hospital,; Hopital de La Charite, France.
Infections with the hepatitis B (HBV) and delta (HDV) viruses and with the human immunodeficiency virus (HIV) are very common among intravenous drug addicts. The serum of 80 percent of drug addicts contains one of the HBV markers, and 15 percent of them carry an anti-D antibody. Infections with the hepatitis A and non
Cell. 1989 Dec 1;59(5):789-95. Unique Identifier : AIDSLINE MED/90075223
Chang DD; Sharp PA; Center for Cancer Research, Massachusetts Institute of; Technology, Cambridge 02139.
The ability of the Rev protein of HIV to regulate the cytoplasmic level of unspliced RNA from a beta-globin gene containing the Rev response element was dependent on the integrity of the 5 and 3 splice sites. A beta-globin pre-mRNA containing the Rev response element is not under regulation by Rev but is made Rev re
Some similarities and several differences in the epidemiological, morphological, therapeutic, and prognostic features of HIV-associated disseminated HZV infection and disseminated HZV infection occurring in HIV-seronegative immunosuppressed patients exist. The severity of the cutaneous disseminated HZV infection, the
Preston SJ; Buchanan WW; Florance and Cope Professional Department of Rheumatology, Royal; North Shore Hospital, St. Leonards, NSW, Australia.
This article reviews the rheumatic manifestation of the immune deficiency disorders. In particular, the rheumatic manifestations of hypogammaglobulinaemia and the acquired immune deficiency syndrome (AIDS) are discussed.
Connor E; Bardeguez A; Apuzzio J; UMD-New Jersey Medical School.
The number of HIV-infected pregnant women in the United States is steadily increasing. While seroprevalence rates vary widely by geography, as many as 2 to 5 per cent of pregnant women in epicenters are seropositive. Medical management of the HIV-infected woman during labor and deliver
Stein DK; Sugar AM; Evans Memorial Department of Clinical Research, Boston University; School of Medicine, Massachusetts.
With the increased number of immunocompromised patients there has been a concomitant increase in patient morbidity and mortality due to fungi. The etiologic microorganisms vary depending upon the type of immune dysfunction. Patients with malignancies and chemotherapy-induced neutropenia commonly are infected with Cand
Rufli T; Department of Dermatology, University Hospital, Basel,; Switzerland.
Treponema pallidum and HIV are both sexually transmitted agents of infectious diseases with epidemiological similarities. Ulcerous genital diseases such as primary syphilis facilitate transmission of HIV. An increasing number of case reports gives evidence that in HIV-infected patients secondary syphilis runs a more s
Bouhnik Y; Chaussade S; Robin P; Gobert JG; Couturier D; Guerre J; Service de Gastroenterologie, Hopital Cochiu, Paris.
A 35-year-old HIV positive patient with skin and gastrointestinal localization of a Kaposi s sarcoma was admitted for severe diffuse edema. Increased alpha-I-antitrypsin clearance (150 ml/24 h) allowed us to confirm the diagnosis of protein loosing enteropathy resulting from sarcoma infiltration in the stomach, the du
Decker MD; Schaffner W; Vanderbilt University School of Medicine, Nashville, Tennessee.
From the staphylococcal era through the gram-negative era into the AIDS era, hospital infection control has evolved into a dynamic discipline whose horizons are broadening to include many of the challenges facing hospitals today.
Hopkins CC; Massachusetts General Hospital, Harvard Medical School, Boston.
The use of universal blood and body-fluid precautions, or universal precautions to prevent the acquisition of blood-borne diseases in health care workers is now widely recommended. Such recommendations are soundly based on a number of biologic, psychologic, and administrative bases. Implementation of the program in an
A high incidence of multiple primary neoplasms has been observed in our patients with ATL in comparison to persons with other forms of hematologic malignancy who we have observed during the past 24 years (1963-1985). Five of 15 patients with ATL (33.3%) have had at least one other associated neoplasm in comparison to
Krone A; Schaal KP; Brawanski A; Schuknecht B; Department of Neurosurgery, University of Wurzburg, West; Germany.
A 72 year old female with cerebral abscess due to Nocardia farcinica is reported. Needle aspiration, antimicrobial therapy using a new combination of imipenem and amikacin, and, finally, surgical excision led to prompt and complete recovery. This is the oldest patient to survive cerebral nocardiosis reported in the li
Wendel GD Jr; Department of Obstetrics and Gynecology, University of Texas; Southwestern Medical School, Dallas.
The incidence of infectious syphilis is increasing in the United States , particularly among women. Not surprisingly, congenital syphilis rates have also risen. These have led to a rekindling of interest in the manifestations and treatment of primary, secondary, and latent syphilis. Coi
Wenstrom KD; Gall SA; Department of Obstetrics and Gynecology, University of Iowa; Hospitals and Clinics, Iowa City.
Acquired immunodeficiency syndrome (AIDS) cripples the immune system, making the patient susceptible to a variety of infections and disorders. AIDS is caused by direct blood contact with a transmissible agent, now known as the human immunodeficiency virus (HIV). The pathophysiology, clinical disease, and treatment of
McGregor JA; French JI; Spencer NE; Department of Obstetrics and Gynecology, University of Colorado; Health Sciences Center, Denver.
Sexually transmitted diseases (STDs) are among the most common infections worldwide. Spread by sexual contact, various STDs directly cause much morbidity and mortality. General as well as specific aspects of STD prevention are discussed.
Proc Natl Acad Sci U S A. 1989 Dec;86(23):9188-92. Unique Identifier : AIDSLINE MED/90083233
Konig R; Ashwell G; Hanover JA; Laboratory of Biochemistry and Metabolism, National Institute of; Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.
CD4 is a T-cell surface glycoprotein and serves as the receptor for the human immunodeficiency virus. Glycosylation of CD4 has been shown to be necessary for proper surface expression. To study the biosynthesis and assembly of CD4, wild-type and glycosylation-deficient mutant Chinese hamster ovary (CHO) cells were cot
Proc Natl Acad Sci U S A. 1989 Dec;86(23):9544-8. Unique Identifier : AIDSLINE MED/90083304
Kim S; Ikeuchi K; Byrn R; Groopman J; Baltimore D; Whitehead Institute, Nine Cambridge Center, MA 02142.
Human immunodeficiency virus type 1 (HIV-1) contains an open reading frame called nef at the 3 end of its genome. The nef gene product has been reported to down-regulate viral growth by suppressing viral transcription through interaction with the long terminal repeat region. We have compared two isogenic HIV-1 (HIV-1
Proc Natl Acad Sci U S A. 1989 Dec;86(23):9549-53. Unique Identifier : AIDSLINE MED/90083305
Hammes SR; Dixon EP; Malim MH; Cullen BR; Greene WC; Howard Hughes Medical Institute, Duke University Medical Center,; Durham, NC 27710.
The type 1 human immunodeficiency virus (HIV-1) encodes a 27-kDa protein termed Nef (negative factor). Nef has been reported to down-regulate viral gene transcription directed by the HIV-1 long terminal repeat. To assess the possible role of Nef in the initiation or maintenance of viral latency, we prepared two differ
Levy JH; Liss RA; Maguire AM; Department of Ophthalmology, Sinai Hospital of Baltimore,; Maryland.
Epidemiologic studies have demonstrated a strong association between human immunodeficiency virus (HIV) and syphilitic infection. Recent reports have suggested that concurrent HIV and luetic infection may lead to an accelerated and more fulminant course of syphilis. Specifically, neurosyphilis is encountered much earl
Bloch AB; Rieder HL; Kelly GD; Cauthen GM; Hayden CH; Snider DE; Division of Tuberculosis Control, Centers for Disease Control,; Atlanta, GA 30333.
Tuberculosis (TB) in the United States is primarily and increasingly a disease of minorities and the foreign-born. TB among non-Hispanic whites is predominantly a disease of the elderly, while among minorities and the foreign-born, it is primarily concentrated in young adults. In the p
Hanson CA; Reichman LB; Department of Medicine, University of Medicine and Dentistry of; New Jersey, New Jersey Medical School, Newark.
Tuberculin skin testing is a reliable tool for the detection of tuberculous infection and the eventual prevention of tuberculous disease. False-negative tests may occur in individuals with a compromised immune system, including those with human immunodeficiency virus (HIV) infection, persons taking immunosuppressive d
Fertel D; Pitchenik AE; University of Miami Medical Center, FL 33125.
The acquired immune deficiency syndrome (AIDS) epidemic has resulted in a rising incidence of tuberculosis (TB) in the United States , especially in inner cities where AIDS is prevalent and among human immunodeficiency virus (HIV) infected subpopulations with a relatively high backgroun
Nardell EA; Harvard Medical School, Cambridge Hospital, MA.
Tuberculosis (TB) is a problem in some institutions, but not in others. Six factors may be used to assess the risk of TB in an institution: the entrance-point prevalence of infection among institutional residents and staff, the potential for reactivation, the role of transmission within the institution, the potential
Rosenberg ZF; Fauci AS; National Institute of Allergy and Infectious Diseases, Bethesda.
Infection with human immunodeficiency virus (HIV) causes an extensive array of immunologic abnormalities which ultimately lead to severe immunosuppression, opportunistic disease, and death. Many of the immunologic defects can be attributable to the quantitative and qualitative deficiencies of T4 lymphocytes caused by
Science. 1989 Dec 22;246(4937):1625-9. Unique Identifier : AIDSLINE MED/90084526
Dayton ET; Powell DM; Dayton AI; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Disease, Bethesda, MD 20892.
Expression of high levels of the structural proteins of the human immunodeficiency virus type 1 (HIV-1) requires the presence of the protein encoded by the rev open reading frame (Rev) and its associated target sequence CAR (cis anti-repression sequence) which is present in the env region of viral RNA. Extensive mutag
Sex Transm Dis. 1989 Oct-Dec;16(4):201-9. Unique Identifier : AIDSLINE MED/90084830
Bibel DJ; Elie Metchnikoff Memorial Library, Oakland, California.
The recent social and scientific confrontations with acquired immune deficiency syndrome (AIDS) echo those of syphilis 100 years ago. Various historical parallels and outright recurrences in politics and medical ethics, in the courts and in the laboratory, are presented to show the failure of government and other soci
Epidemiological evidence indicates that transmission of human immunodeficiency virus (HIV) other than by direct inoculation or sexual contact is extremely rare. HIV has, however, been found on fibreoptic bronchoscopes used on patients with AIDS and there is a clear theoretical risk of transmission by bronchoscopy. App
Wien Med Wochenschr. 1989 Aug 31;139(15-16):342-5. Unique Identifier : AIDSLINE MED/90085939
Male O; I. Universitats-Hautklinik Wien.
This article gives a survey of the most important general aspects of mycoses. This comprises their spectrum of organisms, their pathogenicity and their nosologic features. In a more detailed way, the following topical forms of infections will be discussed: Mycoses favoured by factors of civilization, survival mycoses,
Am J Pathol. 1989 Dec;135(6):1025-33. Unique Identifier : AIDSLINE MED/90086988
Nerenberg MI; Wiley CA; Department of Neuropharmacology, Research Institute of Scripps; Clinic, La Jolla, California.
The HTLV-1 tax gene under control of the HTLV-1 long terminal repeat (LTR) was introduced into transgenic mice. Previously tax protein expression in the muscle and peripheral nerves of three independent mouse lines was reported. Here the localization of this transgenic protein at a cellular and subcellular level is de
Ann Trop Med Parasitol. 1989 Feb;83(1):37-49. Unique Identifier : AIDSLINE MED/90087959
Fleming AF; Tropical Diseases Research Centre, Ndola, Zambia.
The aetiology of severe anaemia (haemoglobin less than 7.0 g dl-1) has been studied in 37 pregnant Zambians. Aetiology was usually multiple; 31 (84%) had Plasmodium falciparum malaria, 23 (62%) were folate deficient, 13 (35%) were iron deficient, one had sickle-cell anaemia and one had the acquired immunodeficiency sy
Espinoza LR; Aguilar JL; Berman A; Gutierrez F; Vasey FB; Germain BF; Department of Internal Medicine, University of South Florida; College of Medicine, Tampa.
Loiacono BR; Carter GR; Carter CS; Leitman SF; Klein HG; Department of Transfusion Medicine, Warren G. Magnuson Clinical; Center, National Institutes of Health 20892.
To determine the efficacy of various methods of confidential unit exclusion (CUE) among donors at increased risk of HIV exposure, we surveyed AABB institutional members on their experience with 3 CUE methods: ballot or barcode, completed at the time of donation, and call-back, performed by the donor after leaving the
Portegies P; de Gans J; Lange JM; Derix MM; Speelman H; Bakker M; Danner SA; Goudsmit J; Academic Medical Centre, University of Amsterdam, The; Netherlands.
OBJECTIVE--To assess the incidence of the AIDS dementia complex and the presence of HIV I p24 antigen in cerebrospinal fluid in relation to zidovudine treatment. DESIGN--Retrospective study of a consecutive series of patients with AIDS from 1982 to 1988. SETTING--An academic centre
Abergel C; Loret E; Claverie JM; Laboratoire de Cristallogenese et de Cristallographie des; Macromolecules Biologiques URA 232-CNRS, Paris, France.
The structure of two T-immunogenic peptides, one from the gag p24 protein of the human immunodeficiency virus, the other from the 11.1 gene product of Plasmodium falciparum, was studied by circular dichroism spectroscopy in various pH and solvent conditions. Although both sequences are predicted to adopt an alpha-heli
Martin P; Di Bisceglie AM; Kassianides C; Lisker-Melman M; Hoofnagle JH; Liver Diseases Section, National Institute of Diabetes and; Digestive and Kidney Diseases, Bethesda, Maryland.
No information is available on the role of non-A, non-B hepatitis in the various hepatic abnormalities described in patients with the acquired immune deficiency syndrome. Of 97 patients referred with suspected non-A, non-B hepatitis, 3 were found to have antibody to the human immunodeficiency virus. These latter 3 pat
de Biasi R; Miraglia E; Mastrullo L; Rocino A; Pisani M; Ruocco V
The authors report the natural history of HIV infection in a patient with severe hemophilia A who became HIV-seropositive in 1983 and, four years later, developed full-blown AIDS associated with a disseminated Kaposi s sarcoma. Neutralizing antibody titers against HIV were shown to be inversely disease-associated, whi
Nakakuma H; Kawaguchi T; Koito A; Hattori T; Kagimoto T; Takatsuki K; Second Department of Internal Medicine, Kumamoto University; Medical School.
As the first step in human immunodeficiency virus (HIV) infection, HIV binds to CD4 molecules on the surface of human T lymphocytes. Expression of CD4 by the cells is remarkably modulated by exogenously added gangliosides, which are normal components of the surface of animal cells. We report here that these physiologi
Shimizu K; Hamajima N; Ohnishi K; Hara K; Kunii A; Department of Medicine, Fujita Gakuen Health University School of; Medicine, Aichi.
This study was undertaken to determine which if any pretreatment factors are statistically significant determinants of the clinical outcome in patients with non-Hodgkin s lymphoma . The pretreatment factors in 20 patients with T-cell lymphoma, including two patients with adult T-cel
Maury CP; Fourth Department of Medicine, University of Helsinki, Finland.
The relation between the inflammatory cytokine tumour necrosis factor-alpha (TNF or cachectin), which induces acute phase responses, and an established acute phase protein, C-reactive protein, was studied in various infectious and inflammatory diseases in man. All cases with very high serum concentrations of C-reactiv
Skolnik PR; Kosloff BR; Bechtel LJ; Huskins KR; Flynn T; Karthas N; McIntosh K; Hirsch MS; Department of Medicine, Tufts University, New England Medical; Center, Boston, MA 02111.
Urine and peripheral blood samples from 48 human immunodeficiency virus type 1 (HIV-1) seropositive individuals (38 adults and 10 children) were evaluated for the presence of HIV-1 by cocultivation and for HIV-1 p24 antigen by ELISA. None of the urine samples contained replication-competent HIV-1; 41 (85%) of 48 simul
Cutaneous lesions of adult T-cell lymphoma on the bilateral temples in a 74-year-old male were treated either with rINF-gamma and local hyperthermia or rIFN-gamma alone. The size of the tumor on the left temple was reduced by 40% 10 days after the therapy was initiated by the intravenous administration of rIFN-gamma (
Simberkoff MS; New York Veterans Administration Medical Center, New York.
Over 91,000 cases of AIDS have been reported in United States , and it has been estimated that more than 1 million individuals are currently infected by the human immunodeficiency virus (HIV). The disease is growing most rapidly among intravenous drug abusers and minority patients. This
N Engl J Med. 1989 Dec 14;321(24):1626-31. Unique Identifier : AIDSLINE MED/90066613
Coombs RW; Collier AC; Allain JP; Nikora B; Leuther M; Gjerset GF; Corey L; Department of Laboratory Medicine, University of Washington,; Seattle 98105.
To determine which markers of human immunodeficiency virus type 1 (HIV) replication correlate most closely with progressive disease, we compared the following: (1) the frequency of isolation of HIV from peripheral-blood mononuclear cells (PBMC), (2) the frequency of isolation of the virus from cell-free plasma (plasma
Public Health Rep. 1989 Nov-Dec;104(6):552-9. Unique Identifier : AIDSLINE MED/90068758
Bowles J; Robinson WA; University of Pennsylvania.
The Office of Minority Health (OMH) was established in December 1985 in response to recommendations developed by the Secretary s Task Force on Black and Minority Health. Originally, OMH s mission emphasized six health problems identified by the Task Force as priority areas: cancer, cardiovascular disease and stroke; c
Public Health Rep. 1989 Nov-Dec;104(6):560-5. Unique Identifier : AIDSLINE MED/90068759
Moran JS; Aral SO; Jenkins WC; Peterman TA; Alexander ER; Center for Prevention Services, Division of Sexually Transmitted; Diseases, Atlanta, GA 30333.
Sexually transmitted diseases (STD) are more prevalent among some minority populations in the United States than they are among the white majority. Primary and secondary syphilis occurs 45 times as often among non-Hispanic blacks as among non-Hispanic whites and 13 times as often among
Public Health Rep. 1989 Nov-Dec;104(6):646-53. Unique Identifier : AIDSLINE MED/90068772
Snider DE Jr; Salinas L; Kelly GD; Division of Tuberculosis Control, Centers for Disease Control,; Atlanta, GA 30333.
Although the number of tuberculosis cases reported annually in the United States has decreased markedly during the past three and a half decades, the decrease among whites has been considerably greater than among nonwhites. As a result of this widening gap, nearly two-thirds of the cas
Bottiger B; Morfeldt-Manson L; Putkonen P; Nilsson B; Julander I; Biberfeld G; Department of Immunology, Karolinska Institute, Stockholm,; Sweden.
From 1982 to 1985, 89 HIV-1 seropositive men with persistent generalized lymphadenopathy (PGL) were enrolled into a prospective longitudinal study. In February 1988, after a mean observation time of 45 months, 23 patients had progressed to AIDS with opportunistic infection (AIDS/OI), 4 had developed Kaposi s sarcoma,
Wakabayashi Y; Sugimoto M; Ishiyama T; Hashimoto M; Horie S; Hirose S; Department of Internal Medicine, Juntendo University School of; Medicine, Tokyo, Japan.
In order to study the abnormal differentiation and proliferation of precursor T cells in homosexual men, a study was made of T-cell colony formation in 15 healthy homosexual men without anti-human immunodeficiency virus (HIV) antibody. The colony forming method used was the one-step monolayer technique using phytohema
Tryba M; Universitatsklinik fur Anaesthesiologie, Intensiv- und; Schmerztherapie, Bergmannsheil Bochum.
About 2% of patients in central Europe who receive transfusions of whole blood or blood components still develop typical transfusion-induced infections, most often non-A-non-B hepatitis. The risk of infection increases in direct correlation to the number of transfused units, which mainly means the number of different
BMJ. 1989 Oct 28;299(6707):1076-9. Unique Identifier : AIDSLINE MED/90074760
Glanz A; Byrne C; Jackson P; Institute of Psychiatry, Addiction Research Unit, London.
OBJECTIVE--To determine the current and potential roles of community pharmacists in the prevention of AIDS among misusers of injected drugs. DESIGN--Cross sectional postal survey of a one in four random sample of registered pharmacies in England and Wales. SETTING--Project conducted in the addiction research unit of t
Willoughby PB; Lisker A; Folds JD; Clinical Microbiology-Immunology Laboratories, North Carolina; Memorial Hospital, Chapel Hill, NC 27514.
Three enzyme immunoassay (EIA) methods for the detection of human immunodeficiency virus (HIV-1) were evaluated. Serum or plasma samples from 22 individuals seropositive for HIV-1 antibodies were tested with the Abbott, Coulter, and DuPont kits for presence of HIV-1 p24 antigen. Another 12 samples were tested with two
Burgisser P; Odier L; Schupbach J; Frei PC; Division of Immunology and Allergy, Centre Hospitalier; Universitaire Vaudois, Lausanne, Switzerland.
Few cases of human immunodeficiency virus type 2 (HIV-2) infection have been reported in individuals other than of West African origin. The first well documented case of HIV-2 infection observed in a Swiss subject is presented here. The 50-year-old woman had a sexual relationship with a Senegalese man, who was later s
Vercauteren G; Piot P; Vandenbruaene M; van der Groen G; Department of Microbiology, Institute of Tropical Medicine,; Antwerp, Belgium.
The performance of two HIV antigen enzyme immunoassays (EIAs), the HTLV-III antigen EIA (Abbott) and the Innotest HIV antigen EIA (Innogenetics), was assessed using 276 HIV-1 antibody positive and 42 HIV antibody negative sera from European and African individuals. On the initial screening 16% (51/318) of the sera wer
Kiehn TE; Diagnostic Microbiology Laboratory, Memorial Sloan-Kettering; Cancer Center, New York, New York 10021.
Considerable changes have occurred during the 1980s in the clinical nature and diagnosis of bacteremia and fungemia in the immunocompromised patient. Cancer patients with prolonged neutropenia, many with indwelling catheters, and AIDS patients with both T-cell and B-cell deficiencies have changed the spectrum of organ
Ikeda S; Kinoshita K; Amagasaki T; Momita S; Soda H; Ito M; Kanda T; Tachibana K; Doi H; Tsuji Y; et al
Infection of HTLV-1 during childhood may be the most probable cause of leukemogenesis of ATL. The possibility of mother to child transmission of HTLV-1 was studied. Our epidemiological investigation disclosed that almost all mothers of HTLV-1 carrier children were positive for anti-HTLV-1 antibody and children born fr
Stambuk D; Youle M; Hawkins D; Farthing C; Shanson D; Farmer R; Lawrence A; Gazzard B; St Stephens Hospital, London.
The efficacy and toxicity of oral azidothymidine has been studied in 145 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC). The median survival time of AIDS patients on azidothymidine was 4.5 times higher when compared to a historical AIDS group who had not received the drug. Th
Thromb Haemost. 1989 Nov 24;62(3):835-9. Unique Identifier : AIDSLINE MED/90085147
Mariani G; Solinas S; Pasqualetti D; Ghirardini A; Verani P; Butto S; Lopez M; Moretti T; Dipartimento di Biopatologia Umana, Universita di Roma La; Sapienza, Italy.
Three hemophiliacs with high titre inhibitor were treated with a medium-high FVIII dose schedule (100 IU/kg bw daily) with the aim of inducing the immunotolerance. These patients were followed-up extensively concerning their immunological status and HIV serology. In all of them the inhibitor disappeared and normal FVI
Kunsch C; Wigdahl B; Department of Microbiology and Immunology, Pennsylvania State; University, College of Medicine, Hershey 17038.
Human immunodeficiency virus type 1 (HIV-1), the etiologic agent of acquired immunodeficiency syndrome (AIDS), has been implicated in the generation of AIDS-associated neurologic dysfunction. We are currently examining the replicative processes involved in HIV-1 infection of selected human fetal neural cell population
Ann Intern Med. 1989 Dec 15;111(12):961-72. Unique Identifier : AIDSLINE MED/90087496
Wolinsky SM; Rinaldo CR; Kwok S; Sninsky JJ; Gupta P; Imagawa D; Farzadegan H; Jacobson LP; Grovit KS; Lee MH; et al; Northwestern University Medical School, Chicago, Illinois.
STUDY OBJECTIVE: To study the natural history of human immunodeficiency virus type 1 (HIV-1) infection, we used an in-vitro amplification technique to detect HIV-1 nucleic acid sequences in sequential aliquots of peripheral blood mononuclear cells from homosexual men enrolled in the Multicenter AIDS Cohort Study. DESI
Ann Intern Med. 1989 Dec 15;111(12):973-81. Unique Identifier : AIDSLINE MED/90087497
Holland HK; Saral R; Rossi JJ; Donnenberg AD; Burns WH; Beschorner WE; Farzadegan H; Jones RJ; Quinnan GV; Vogelsang GB; et al; Johns Hopkins School of Medicine, Baltimore, Maryland.
Human immunodeficiency virus type 1 (HIV-1)-infected patients with non-Hodgkin lymphoma are classified as having the acquired immunodeficiency syndrome (AIDS). Allogeneic bone marrow transplantation is a successful therapy for patients with lymphoma who have a poor prognosis. Combined therapy with allogeneic bone marr
Soria AG; Picchio GR; Bouzas MB; Muchinik GR; Anselmo A; Perez Bianco R; de Bracco MM; Ruibal-Ares BH
The alloantigen responses of hemophilic patients was evaluated using a unidirectional mixed lymphocyte culture (MLC). The results of this study indicate that both the ability of peripheral blood mononuclear cells (PBMC) to proliferate in response to alloantigens and the capacity to stimulate the MLC are impaired in he
Pillai S; Mahmood MA; Limaye SR; Department of Ophthalmology, D.C. General Hospital, Washington,; D.C. 20003.
A 42-year-old man presented with herpes zoster ophthalmicus on the right side. He was found to have acquired immune deficiency syndrome-related complex. Two weeks later he developed toxoplasmic retinochoroiditis in the left eye. He also presented later with left hemiplegia, which was probably caused by herpes zoster a
According to cautious estimations some 60,000-120,000 HIV-infected persons are currently living in the FRG. The presence of HIV in almost every body fluid has lead to a lively discussion about the potential of a nosocomial infection of health care workers caring for HIV-infected and AIDS patients. The results of ongoi
The AIDS Control Programme of the Federal Government is the first national programme in the Federal Republic of Germany , trying to prevent the spread of a specific disease on a broader scale. The question is raised whether the present highly legally orientated Public Health servic
The Model project Public Health Departments , part of the West German government s AIDS Action Programme, supports the employment of an AIDS counsellor in every local public health department. The Institute for Health Systems Research Kiel designed a reporting system for the model project. After reaching an agreemen
AIDS has stimulated public interest in the legal aspects of the Federal German Law on Epidemic Diseases. Publications do not always accurately describe the legal situation. Land governments should have paid more attention to the provisions restricting the use of disinfectants to certain approved products. Some regulat
Previous work had shown that HIV-1 is a large group of highly divergent viruses, which mutate quickly in the infected person. The analysis of two HIV-2 strains by molecular cloning and sequence analysis has now proved that HIV-2 is a large and very divergent family of viruses as well and that genetically different sub
The AIDS-Hilfe movement-more than 80 local groups are presently united in the Federal German organization of the Deutsche AIDS-Hilfe e. V. -looks back at a more than five years of experience in the fields of prevention for different target groups, counselling, care, PR-work and representation of interests. Central poi
Ugeskr Laeger. 1989 Oct 23;151(43):2784-7. Unique Identifier : AIDSLINE MED/90070295
Westh H
Hepatitis-B infections can be prevented by vaccination. Although a safe and efficacious plasma-derived vaccine has been available in Denmark since 1983, only approximately 7,000 persons have been vaccinated. This was among other thi
Am J Cardiol. 1989 Dec 1;64(19):1396-9. Unique Identifier : AIDSLINE MED/90071843
Himelman RB; Dohrmann M; Goodman P; Schiller NB; Starksen NF; Warnock M; Cheitlin MD; Department of Medicine, University of California, San Francisco; 94143.
Liu CM; Muirhead KA; George SP; Landay AL; Department of Immunology, Smith Kline and French Laboratories,; Philadelphia, Pennsylvania.
The utility of CD4 lymphocytes in monitoring disease progression and prognosis of human immunodeficiency virus (HIV)-infected patients is well established. We have modified a previously described antibody cocktail to provide complete lymphocyte subset analysis on 100-200-microL samples of whole blood. This method opti
Am J Epidemiol. 1989 Dec;130(6):1167-75. Unique Identifier : AIDSLINE MED/90072051
Hessol NA; Lifson AR; O'Malley PM; Doll LS; Jaffe HW; Rutherford GW; Department of Public Health, City and Country of San Francisco,; CA.
Between 1978 and 1980, 359 hepatitis B seronegative homosexual and bisexual men were recruited from the San Francisco municipal sexually transmitted disease clinic for hepatitis B vaccine trials. Of the 359 participants, 320 (89%) consented to have their stored blood samples tested for human immunodeficiency virus ant
Chanh TC; Allan JS; Matthews JL; Sogandares-Bernal F; Judy MM; Skiles H; Leveson J; Marengo-Rowe A; Newman JT; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, TX 78284.
A photodynamic flow system employing a dihematoporphyrin ether (DHE) was tested for its ability to inactivate the in vitro infectivity of simian immunodeficiency virus (SICMac) at 630 +/- 5 nm with a light fluence of 5 J/cm2. Cell-free SIVMac was inactivated by photoactivated hematoporphyrin derivative in a dose-depen
Science. 1989 Dec 22;246(4937):1629-32. Unique Identifier : AIDSLINE MED/90084527
Cheng-Mayer C; Iannello P; Shaw K; Luciw PA; Levy JA; Department of Medicine, University of California, San Francisco; 94143.
Stable lymphoid cell lines expressing the human immunodeficiency virus type 1 (HIV-1) nef gene product, p27, were established. The presence of p27 in the lymphoid cells suppressed replication of some strains of both HIV-1 and HIV-2. This observation indicates that nef could be important in the establishment of HIV lat
Bull Math Biol. 1989;51(6):715-30. Unique Identifier : AIDSLINE MED/90057809
Spouge JL; Layne SP; Dembo M
In a separate paper, we developed a mathematical model describing HIV infection and used it to suggest experiments for quantifying characteristic viral parameters. In this paper we generalize the model to any well-mixed assay system. We also present complete and rigorous derivations of fundamental results needed for t
Carrazana EJ; Rossitch E Jr; Samuels MA; Division of Neurology, Brigham and Women's Hospital, Harvard; Medical School, Boston, Massachusetts 02115.
We examined the clinical and pathological features of 26 patients who presented with a diagnosis of CNS toxoplasmosis. Patient data was analyzed with respect to demographics, clinical presentation, treatment course and pathology. Patients presented with a wide variety of signs and symptoms. All patients had positive s
A murine T cell hybridoma with a receptor specific for the class I molecule H-2 Dd was transfected with an expressible cDNA for human CD4. Expression of the human class II MHC molecule HLA-DP on Dd-positive murine fibroblasts resulted in a greatly enhanced response of the CD4-positive T cell hybridoma, measured either
Between 1985 and 1989 108 HIV-positive patients underwent cytologic examinations at the Dept. of Obstetrics and Gynecology, Univ. of Berlin. These patients showed 15 times more pathologic smears (group IIId to V) than all other patients of the hospital investigated. By histological controls 10 cervical intraepithelial
Matsuura A; Third Department of Internal Medicine, Hokkaido University School; of Medicine, Sapporo.
Immunological state of HIV-infected and HIV-uninfected hemophiliacs are studied as compared with that of healthy controls. (1) EBV-specific cellular immunity observed in HIV infected hemophiliacs is significantly lower than that of HIV-uninfected patients and healthy controls. (2) The titers of anti-EBNA anti-VCA anti
Banerjee R; Karpen S; Siekevitz M; Lengyel G; Bauer J; Acs G; Department of Neoplastic Diseases, Mount Sinai School of; Medicine, City University of New York, New York 10029.
Tumor necrosis factor-alpha is an inducer of acute-phase protein synthesis in liver cells. The mechanism by which tumor necrosis factor-alpha alters gene expression in these cells is largely unknown. In this study, we demonstrate that tumor necrosis factor-alpha stimulates human immunodeficiency virus-1 long terminal
Nakamura M; Niki M; Nagata K; Ohtani K; Saito S; Hinuma Y; Sugamura K; Department of Microbiology, Tohoku University School of Medicine,; Sendai, Japan.
The trans-acting transcriptional factor p40tax of human T-cell leukemia virus type I (HTLV-I) can activate expression not only of its own viral genes but also of other viral and cellular genes. We examined the cis-acting sequences in the simian virus 40 (SV40) enhancer required for its activation by HTLV-I p40tax. Exp
Francis ND; Boylston AW; Roberts AH; Parkin JM; Pinching AJ; Department of Histopathology, St Mary's Hospital, London.
All gastrointestinal tract biopsy specimens from 190 patients positive for HIV-1 or with AIDS were reviewed to assess the prevalence of cytomegalovirus ( CMV ) infection, morphology of infected cells, and the associated histopa
McNeely MC; Yarchoan R; Broder S; Lawley TJ; Dermatology Branch, National Institutes of Health, Bethesda, MD; 20892.
We describe a distinctive mucocutaneous eruption that occurred in 14 of 20 (70%) patients with human immunodeficiency virus infection while they were being treated with a new therapeutic agent, 2 3 -dideoxycytidine. A maculopapular eruption developed in these patients on day 10 or 11 of treatment. Seven of 14 patients
Anderson KP; Lucas C; Hanson CV; Londe HF; Izu A; Gregory T; Ammann A; Berman PW; Eichberg JW; Department of Pharmacological Sciences, Genentech, Inc., South; San Francisco, California 94080.
To evaluate the immunogenicity of purified recombinant envelope glycoprotein of HIV-1 (rgp120) as a potential vaccine for AIDS, the antibody response of 45 baboons to rgp120 was investigated using an adjuvant (alum) and route of administration (intramuscular) suitable for humans. The primary purpose was to evaluate th
Lang DJ; Kovacs AA; Zaia JA; Doelkin G; Niland JC; Aledort L; Azen SP; Fletcher MA; Gauderman J; Gjerset GJ; et al; City of Hope National Medical Center, Duarte, California.
Antibodies to human cytomegalovirus ( CMV ) and Epstein-Barr virus (EBV) were evaluated among 1,171 persons with and without antibodies to human immunodeficiency virus type 1 (anti-HIV-1). These included 97 blood donors, 577 pe
Chavanet P; Solary E; Giroud M; Waldner A; Beuriat P; Nordman P; Portier H; Service des Maladies Infectieuses et Tropicales, Hopital; Universitaire, Dijon, France.
To assess subclinical involvement of the peripheral nervous system and its relationship to the immunological status of human immunodeficiency virus (HIV)-infected patients, we prospectively studied the peripheral nerve conductions and the subsets of peripheral blood lymphocytes of HIV patients. Fifty-seven patients, a
Schrager LK; Friedland GH; Maude D; Schreiber K; Adachi A; Pizzuti DJ; Koss LG; Klein RS; Department of Medicine, Montefiore Medical Center, Albert; Einstein College of Medicine, Bronx, New York 10467.
We sought to determine whether women infected with human immunodeficiency virus (HIV) had cervicovaginal cellular changes suggesting lower genital tract neoplasia or human papillomavirus (HPV) infection at a rate different from that in women without HIV infection. In a blinded fashion, cytological preparations of cerv
Reichart PA; Langford A; Gelderblom HR; Pohle HD; Becker J; Wolf H; Abteilung fur zahnarztliche Chirurgie/Oralchirurgie-Nord-Freie; Universitat Berlin, West Germany.
Oral hairy leukoplakia (HL) was observed in 25.4% of 373 HIV-seropositive patients (n = 95). 87 were men of an average age of 37.1 yr, 8 were women (30.3 yr). 71.6% of the patients were male homosexuals. At initial diagnosis of HL the majority of cases was classified as CDC IVc1 (45.3%) and CDC II (22.1%). Average CD4
J R Coll Gen Pract. 1989 Mar;39(320):101-3. Unique Identifier : AIDSLINE MED/90064280
Bury G; O'Kelly F
A group general practice in Dublin s inner city has had extensive experience of intravenous drug users since the late 1970s. Since 1985 a total of 54 human immunodeficiency virus (HIV) seropositive patients have attended the practice, of whom 48 are intravenous drug users, four are the children of drug users and two h
J R Coll Gen Pract. 1989 Mar;39(320):104-5. Unique Identifier : AIDSLINE MED/90064281
Mansfield SJ; Singh S
In a study of 100 patients with the acquired immune deficiency syndrome (AIDS), 77% were registered with a general practitioner and a further 14% wished to register. Of those 77 who were registered with a general practitioner, only 47 doctors knew their diagnosis; 19 of the 77 did not want their general practitioner t
Fenrick R; Malim MH; Hauber J; Le SY; Maizel J; Cullen BR; Howard Hughes Medical Institute, Department of Medicine, Duke; University Medical Center, Durham, North Carolina 27710.
The trans-activator (Tat) proteins of the related but distinct type 1 and type 2 human immunodeficiency viruses (HIV-1 and HIV-2) display incomplete functional reciprocity. One possible explanation of this observation, suggested by computer analysis of potential RNA secondary structures within the viral trans-activati
Arthur LO; Bess JW Jr; Waters DJ; Pyle SW; Kelliher JC; Nara PL; Krohn K; Robey WG; Langlois AJ; Gallo RC; et al; Program Resources, Inc., National Cancer Institute-Frederick; Cancer Research Facility, Maryland 21701.
The human immunodeficiency virus type 1 (HIV-1), the causative agent of acquired immunodeficiency syndrome, infects humans and chimpanzees. To determine the efficacy of immunization for preventing infection, chimpanzees were immunized with gp120 purified from human T-cell lymphotrophic virus type IIIB (HTLV-IIIB)-infe
Katzman M; Katz RA; Skalka AM; Leis J; Department of Biochemistry, Case Western Reserve University,; Cleveland, Ohio 44106.
The purified integration protein (IN) of avian myeloblastosis virus is shown to nick double-stranded oligodeoxynucleotide substrates that mimic the ends of the linear form of viral DNA. In the presence of Mg2+, nicks are created 2 nucleotides from the 3 OH ends of both the U5 plus strand and the U3 minus strand. Simi
Kitamura T; Yogo Y; Doi N; Ueki T; Moriyama N; Takahashi S; Fukutani K; Kawabe K; Aso Y
Last year, we reported that human papilloma virus type 16 genome (HPV 16 genome) was detected in a case (S.Y.) of bladder carcinoma in situ (bladder CIS) (Cancer Res., 1988). Since then, a number of bladder tumors other than CIS were searched for HPV genome. However, no HPV genome was detected in the bladder tumors. F
Klin Wochenschr. 1989 Nov 3;67(21):1108-15. Unique Identifier : AIDSLINE MED/90065473
Schrappe-Bacher M; Steffen HM; Ollenschlager G; Salzberger B; Fatkenheuer G; Degenhardt S; Kruger GR; Medizinische Klinik II und Poliklinik, Universitat Koln.
Eleven Human Immunodeficiency Virus 1 (HIV1)-infected patients (10 male, 1 female; age 23-51 years (median 36); 10 male homosexuals, 1 IV drug abuser; WR3 1 patient, WR5 5, WR6 5) with intestinal Cytomegalovirus ( CMV )-manifestations were compared with a group of
Numazaki K; Goldman H; Bai XQ; Wong I; Wainberg MA; Montreal Children's Hospital Research Institute, Quebec, Canada.
A tissue culture system for the growth of human fetal and infantile thymic epithelial (TE) cells has been established and characterized. We have investigated the effects of infection of these cells by human cytomegalovirus ( CMV
The review describes the replication and genetic variability of retroviruses. The steps of the replication cycle are detailed for murine leukemia (MuLV) and AIDS (HIV-1) viruses.
Marriott SJ; Boros I; Duvall JF; Brady JN; Laboratory of Molecular Virology, National Cancer Institute,; Bethesda, Maryland 20892.
Several laboratories have demonstrated that tandem copies of the human T-cell leukemia virus type I 21-base-pair (bp) repeat cloned upstream of either a homologous or heterologous promoter increase transcription in the presence of tax1 protein. In this report, we provide evidence for a second tax1-responsive sequence
Scaravilli F; Ellis DS; Tovey G; Harcourt-Webster JN; Guiloff RJ; Sinclair E; Department of Neuropathology, National Hospital, London.
Two HIV-positive male patients presented with a variety of symptoms including hemiparesis, unsteadiness, progressive loss of vision and poor memory. There were multiple non-enhancing lesions shown by CT scan in the white matter of the cerebral hemispheres. Specimens obtained by burr-hole biopsy showed the features of
Young TL; Robin JB; Holland GN; Hendricks RL; Paschal JF; Engstrom RE Jr; Sugar J; UIC Eye Center, University of Illinois at Chicago College of; Medicine 60612.
Acquired immune deficiency syndrome (AIDS) is associated with a wide spectrum of systemic and ocular infectious diseases. Little information is known about herpes simplex virus type 1 (HSV-1) keratoconjunctivitis in association with AIDS. The authors present six cases of recurrent HSV keratitis occurring in AIDS patie
Shibuya H; Taniguchi T; Institute for Molecular and Cellular Biology, Osaka University,; Japan.
Regulated expression of interleukin-2 ( IL-2 ) gene constitutes an essential part in the clonal proliferation of activated T lymphocytes (T-cells). In order to gain insight on the mechanism(s) of the IL-2 gene induction, deletions were introduced in the human IL-2 gene 5
Smith E; Franzmann M; Mathiesen LR; Department of Infectious Diseases, Hvidovre Hospital, University; of Copenhagen, Denmark.
We present the first case of disseminated histoplasmosis in an AIDS patient in Europe, a 33-year-old Danish homosexual man, and recommend a detailed travel history in HIV-positive patients presenting with fever, weight loss and organomegaly. In Scandinavia disseminated histoplasmosis is rare but should be kept in mind
Science. 1989 Dec 8;246(4935):1293-7. Unique Identifier : AIDSLINE MED/90069604
Murphey-Corb M; Martin LN; Davison-Fairburn B; Montelaro RC; Miller M; West M; Ohkawa S; Baskin GB; Zhang JY; Putney SD; et al; Delta Regional Primate Research Center, Tulane University,; Covington, LA 70434.
A vaccine against human immunodeficiency virus (HIV) would be highly effective in stopping the acquired immunodeficiency syndrome (AIDS) epidemic. A comprehensive evaluation of potential vaccine methodologies can be made by means of the simian model for AIDS, which takes advantage of the similarities in viral composit
Verges B; Chavanet P; Desgres J; Vaillant G; Waldner A; Brun JM; Putelat R; Department of Endocrinology, Hopital du Bocage, University of; Dijon, France.
Since anatomopathological lesions of the adrenal gland have been frequently observed at autopsy in AIDS, we investigated the glucocorticoid function in 63 patients (51 men, 12 women) infected by the human immunodeficiency virus (HIV) in order to determine the incidence and the nature of any adrenocortical abnormalitie
Uccini S; Monardo F; Vitolo D; Faggioni A; Gradilone A; Agliano AM; Manzari V; Ruco LP; Baroni CD; Second Chair of Pathological Anatomy, University La Sapienza,; Rome, Italy.
The presence of human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) antigens and genome has been investigated in 50 lymph nodes involved by persistent generalized lymphadenopathy (PGL). All the patients were HIV infected and most of them (42 of 50) also had anti-EBV serum antibodies. At lymph node level, H
Nichols L; Balogh K; Silverman M; Department of Pathology, New England Deaconess Hospital, Lahey; Clinic, Boston, Massachusetts.
In a group of 46 adult patients with acquired immunodeficiency syndrome (AIDS) who came to autopsy in 1983-1987, the authors found that 38 (83%) had bacterial (nonmycobacterial) infections some time during the course of their illness, compared with 34 (74%) who had parasitic infections, 31 (67%) who had viral infectio
Biochem Biophys Res Commun. 1989 Nov 15;164(3):1323-30. Unique Identifier : AIDSLINE MED/90073666
Hicks K; Friedman B; Rosner MR; Massachusetts Institute of Technology, Cambridge 02139.
The conditioned medium of Simian sarcoma virus (SSV)-transformed NRK cells contains at least two activities that down regulate the epidermal growth factor receptor. To identify these activities, we analyzed the medium for the presence of factors both related to and distinct from the v-sis oncogene product. Fractionati
Br Dent J. 1989 Oct 21;167(8):269-74. Unique Identifier : AIDSLINE MED/90074439
Lamey PJ; Lewis MA
The fourth article in this series deals with viral infections which may present in the dental surgery. Two groups of viruses, herpes and coxsackie, are responsible for the majority of viral conditions involving the orofacial region which present to the dentist. Mucosal ulceration is the most frequent clinical presenta
Jones PD; Marriott D; Speed BR; Department of Infectious Diseases, Prince Henry Hospital,; Matraville, N.S.W., Australia.
In this clinical trial, oral fluconazole was used to treat cryptococcal meningitis in 32 patients with Acquired Immune Deficiency Syndrome (AIDS). In 11 patients who received 200 to 400 mg/day of fluconazole as primary therapy, a favorable clinical response was obtained in 67% of all evaluable patients. A negative cer
Ikemoto H; Department of Internal Medicine, Juntendo University School of; Medicine, Tokyo, Japan.
A multicenter clinical study of fluconazole was conducted at 41 hospital sites in Japan . Fluconazole was administered orally or intravenously at daily doses of 50 to 400 mg to 199 patients with deep-seated mycoses. Clinical efficacy was evaluable in 125 of these patients. Most cases
Rudlinger R; Buchmann P; Department of Dermatology, Zurich University Hospital,; Switzerland.
A homosexual man in stage IV of HIV infection, who suffers from HPV 16-positive bowenoid papulosis of the anal region, is described. In one area the patient developed an HPV 16-positive squamous-cell carcinoma of the anus. Bowenoid papulosis represents a squamous-cell carcinoma in situ, and usually follows a benign cl
EMBO J. 1989 Dec 20;8(13):4251-8. Unique Identifier : AIDSLINE MED/90076147
Sambucetti LC; Cherrington JM; Wilkinson GW; Mocarski ES; Department of Microbiology and Immunology, Stanford University; School of Medicine, CA 94305.
The expression of cytomegalovirus alpha (immediate early) genes is under control of an enhancer that carries signals for strong constitutive expression as well as response elements for transactivation by viral proteins. We have used synthetic oligonucleotides representing the 16, 1
FASEB J. 1989 Dec;3(14):2593-606. Unique Identifier : AIDSLINE MED/90076756
Gardner MB; Luciw PA; Department of Medical Pathology, University of California, Davis; 95616.
Animal models of AIDS are essential for understanding the pathogenesis of retrovirus-induced immune deficiency and encephalopathy and for development and testing of new therapies and vaccines. AIDS and related disorders are etiologically linked to members of the lentivirus subfamily of retroviruses; these lymphocytopa
Rush JD; Ng VL; Hopewell PC; Hadley WK; Mills J; Clinical Microbiology Laboratory, San Francisco General Hospital,; California 94110.
The recovery rates of cytomegalovirus from mucolysed induced sputum samples and bronchoalveolar lavage fluid obtained from individuals at risk for or with acquired immunodeficiency syndrome were compared. It was demonstrated that cytomegalovirus could be reliably recovered from muc
Gerberding JL; Department of Medicine, University of California, San Francisco.
Transmission of hepatitis B, HIV-1 and CMV by percutaneous, mucosal, or contact with intact skin is of concern to health care personnel. This article summarizes current information regarding the risks of transmission of these agents and emphasizes infection cont
J R Coll Gen Pract. 1989 Jun;39(323):234-8. Unique Identifier : AIDSLINE MED/90079824
Naji SA; Russell IT; Foy CJ; Gallagher M; Rhodes TJ; Moore MP
To estimate the effect of human immunodeficiency virus (HIV) infection on general practice, a postal survey was undertaken of one in three of all principals in Scotland. Of the 834 general practitioners who responded (78% response rate), 31% were working in practices with patients known to be infected with HIV. The es
J R Coll Gen Pract. 1989 Jul;39(324):280-3. Unique Identifier : AIDSLINE MED/90079850
King MB
A total of 2510 general practitioners in the London postal districts were circulated with a questionnaire about their involvement with patients with human immunodeficiency virus (HIV) infection--1261 (50%) replies could be analysed. Over half of the respondents had at least one patients who was HIV seropositive and mo
J R Coll Gen Pract. 1989 Jul;39(324):284-8. Unique Identifier : AIDSLINE MED/90079851
Naji SA; Russell IT; Foy CJ; Gallagher M; Rhodes TJ; Moore MP
To assess the knowledge and attitudes of general practitioners about HIV infection, a postal survey was undertaken of one in three of all principals in Scotland; 834 (77.6%) responded. Respondents knowledge about HIV was often limited, and they found the discussion of sexual behaviour difficult. Most were in favour o
Inoue T; Furukawa Y; Yamane T; Hiyoshi M; Sasaki A; Kishida T; Im T; Tatsumi N; Sannomiya Y
A 30-year-old man was admitted to our hospital because of fever and cervical lymphadenopathy. Hematological examination revealed leukocytosis with atypical lymphocytes in peripheral blood. Mature histiocytes with erythrophagia were detected in the bone marrow. GOT and GPT were elevated. Anti-EB virus antibody titer wa
Nature. 1989 Dec 7;342(6250):714-6. Unique Identifier : AIDSLINE MED/90081849
Zapp ML; Green MR; Department of Biochemistry and Molecular Biology, Harvard; University, Cambridge, Massachusetts 02138.
The human immunodeficiency virus type 1 (HIV-1) Rev protein acts post-transcriptionally to increase the amounts of the viral gag-pol and env messenger RNAs in the cytoplasm of infected cells. The mechanism of Rev action is uncertain. Possibilities include an accelerating effect on the rate of export of its mRNA target
Data of the literature about frequency and specificity of giant cells during AIDS encephalitis are conflicting. These discrepancies could be explained by several factors. Envelope glycoprotein Gp 120, when free, induces the formation of giant cells through the fusion of cerebral monocytes. The concentration of this pr
Science. 1989 Dec 22;246(4937):1606-8. Unique Identifier : AIDSLINE MED/90084519
Viscidi RP; Mayur K; Lederman HM; Frankel AD; Department of Pediatrics, Johns Hopkins University School of; Medicine, Baltimore, MD 21205.
The purified human immunodeficiency virus type-l (HIV-l) Tat protein inhibited lymphocyte proliferation induced by tetanus toxoid or Candida antigens by 66 to 97% at nanomolar concentrations of Tat. In contrast, Tat did not cause a significant reduction of lymphocyte proliferation in response to mitogens such as phyto
Kuljic-Kapulica N; Zivanovic-Marinkovic V; Saric A; Djokic M
Forty-seven anti-HIV positive sera and 47 sera of normal individuals were analyzed to the presence of IgG and IgM antibodies versus CMV , HSV and VZ. IgG antibodies in comparison to CMV were found in 27 cases (57.44%); in comparison to HSV in 40 (85.1%) subject a
Hatfield D; Feng YX; Lee BJ; Rein A; Levin JG; Oroszlan S; Laboratory of Experimental Carcinogenesis, National Cancer; Institute, Bethesda, Maryland 20892.
An examination of the frameshift signals or proposed signals within published sequences of retroviruses and other genetic elements from higher animals shows that each site utilizes a tRNA which normally contains Wybutoxine (Wye) base or Queuine (Q) base in the anticodon loop. We find experimentally that most of the Ph
Markovitz DM; Kenney S; Kamine J; Smith MS; Davis M; Huang ES; Rosen C; Pagano JS; Department of Medicine, University of North Carolina, Chapel Hill; 27599.
The BMLF1 region of the Epstein-Barr virus (EBV) genome and the immediate-early (IE) region of human cytomegalovirus (HCMV) both encode proteins which can trans-activate heterologous promoter/chloramphenicol acetyl transferase (CAT) constructs, including a human immunodeficiency vi
Am J Gastroenterol. 1989 Dec;84(12):1517-20. Unique Identifier : AIDSLINE MED/90086718
Wu GD; Shintaku IP; Chien K; Geller SA; Department of Pathology and Laboratory Medicine, Cedars-Sinai; Medical Center, Los Angeles, California.
Eighty (80) paraffin-embedded intestinal biopsies from 35 AIDS patients were evaluated for the presence of cytomegalovirus by use of biotinylated DNA probe, immunohistochemical assay, and routine hematoxylin and eosin (H&E) staining. Cytomegalovirus was detected in 13 biopsies (16.
Am J Gastroenterol. 1989 Dec;84(12):1560-3. Unique Identifier : AIDSLINE MED/90086727
Fritz HP; Polio J; Hewitt JK; University of Connecticut Health Center, Division of; Gastroenterology, Farmington.
Biloma has been defined as an extraductular collection of bile within a defined capsular space. Prior reports have documented an association of biloma with abdominal trauma and abdominal surgery. Biloma has not been reported in association with or as the presenting manifestation of hepatocellular carcinoma. In additio
Am J Ophthalmol. 1989 Dec 15;108(6):691-8. Unique Identifier : AIDSLINE MED/90086944
Gross JG; Sadun AA; Wiley CA; Freeman WR; Department of Ophthalmology, University of California San Diego; School of Medicine, La Jolla 92093.
We examined ten patients from a consecutive series of 73 patients with either isolated cytomegalovirus papillitis or limited cytomegalovirus retinitis contiguous with the optic disk. Patients with peripheral retinitis and other areas of retinitis were excluded. All patients were tr
Holland GN; Buhles WC Jr; Mastre B; Kaplan HJ; AIDS Unit, UCLA Uveitis Center, Jules Stein Eye Institute.
To evaluate more accurately the clinical response of cytomegalovirus retinopathy to ganciclovir, a system for the assessment of disease outcome was developed that uses retinal photographs and three factors: development of new lesions, enlargement of preexisting lesions, and change
Heinemann MH; Department of Surgery, Memorial Sloan-Kettering Cancer Center,; New York, NY.
The safety and efficacy of intravitreously administered ganciclovir sodium as sole treatment for cytomegalovirus retinitis complicating the acquired immunodeficiency syndrome was studied prospectively in seven patients. All but one of the patients had bilateral cytomegalovirus reti
Lee CA; Phillips A; Elford J; Miller EJ; Bofill M; Griffiths PD; Kernoff PB; Academic Department of Haematology, Royal Free Hospital School of; Medicine, London.
112 haemophilic patients infected with HIV were followed up with clinical and laboratory assessment between 1 December 1979 and 30 November 1988. Sixty-six (59%) of the patients developed HIV-related clinical symptoms and 22 (20%) developed AIDS. Twenty (18%) of the patients developed p24 antigenaemia. Amongst the 59
EMBO J. 1989 Oct;8(10):3019-27. Unique Identifier : AIDSLINE MED/90059887
Ensoli B; Lusso P; Schachter F; Josephs SF; Rappaport J; Negro F; Gallo RC; Wong-Staal F; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20892.
Human Herpes virus-6 (HHV-6) can co-infect with HIV-1 human CD4+ T-cells, leading to accelerated cell death, and factors in HHV-6-infected cells stimulate HIV-1 LTR directed gene expression. In this study, we have examined the mechanism of HIV-1 activation by HHV-6 and localized the cis-acting sequences of HIV-1 LTR r
Demeter J; Paloczi K; Foldi J; Hokland M; Hokland P; Benczur M; Lehoczky D; National Institute of Haematology and Blood Transfusion,; Budapest, Hungary.
A hairy cell leukaemia (HCL) patient is presented in whom the peripheral blood mononuclear cells (PBMCs) carried suppressor T-cell markers (CD3+, CD2+, CD8+/CD4-, CD38+). Analysis of genomic DNA of PBMNC showed the presence of a monoclonal population of T cells, the T-cell receptor (TCR) beta-chain gene being rearrang
Invernizzi R; Perugini O; De Fazio P; Bonetti F; Nespoli BL; Department of Internal Medicine, University of Pavia, Italy.
The cytochemical distribution of dipeptidylaminopeptidase IV (DAP IV) was studied in 5 cases of T lymphoblastic leukaemic lymphoma and 12 cases of acute T lymphoblastic leukaemia, in order to ascertain differences between the enzyme positivity patterns of T cells at different stages of differentiation. Early thymic ph
Brinchmann JE; Gaudernack G; Thorsby E; Jonassen TO; Vartdal F; Institute of Transplantation Immunology, National Hospital, Oslo,; Norway.
A procedure for reliable and reproducible isolation of human immunodeficiency virus (HIV) from cultures of CD4+ T cells from healthy HIV seropositive individuals is described. Using immunomagnetic cell separation techniques, CD4+ T cells were positively selected from blood or peripheral blood mononuclear cells from 34
Ragni MV; Kingsley LA; Nimorwicz P; Gupta P; Rinaldo CR; Department of Medicine, University of Pittsburgh School of; Medicine, Pennsylvania.
Six (13%) of 45 female partners of 45 HIV antibody positive [Ab(+)] hemophiliacs in Western Pennsylvania have become HIV Ab(+), a mean of 10.4 months from the time of first exposure. By comparison, the mean time from first exposure to the last/recent exposure in the HIV Ab(-) female partners was 54.2 months. All six h
Dodon MD; Bernard A; Gazzolo L; Immuno-Virologie Moleculaire et Cellulaire, UMR30 Centre; National de la Recherche Scientifique-Universite Claude Bernard,; Lyon, France.
Human T-cell leukemia virus type I (HTLV-I) is etiologically associated with adult T-cell leukemia, an aggressive lymphoproliferative disorder, and with chronic neurological diseases. In vitro it can infect several types of cells but transforms only human T lymphocytes. We have previously shown that HTLV-I viral parti
Am J Med. 1989 Dec;87(6):628-32. Unique Identifier : AIDSLINE MED/90072223
Hollander H; Lifson AR; Maha M; Blum R; Rutherford GW; Nusinoff-Lehrman S; Department of Medicine, University of California, San Francisco; 94143.
PURPOSE: The combination of zidovudine and acyclovir has shown in vitro antiretroviral activity and led to short-term improvement in patients with symptomatic human immunodeficiency disease (HIV) disease. We performed a phase I study of zidovudine (500 mg/day) plus acyclovir (2
A technique for isolation of HIV using selective cultures of T4 cells obtained from peripheral blood by immunochemical separation was developed and optimized. Using this method infectious virus could be isolated in single isolation attempts from 89% of 35 HIV-infected patients in different stages of immunodeficiency.
Clerici M; Stocks NI; Zajac RA; Boswell RN; Lucey DR; Via CS; Shearer GM; Experimental Immunology Branch, National Cancer Institute,; Bethesda, Maryland 20892.
We have tested the T helper cell (TH) potential of asymptomatic, HIV seropositive (HIV+) patients, using an in vitro assay for IL-2 production. Peripheral blood leukocytes (PBL) from 74 HIV+ patients and 70 HIV- control donors were tested for TH function when stimulate
J Immunol. 1989 Dec 15;143(12):3956-60. Unique Identifier : AIDSLINE MED/90078995
Israel N; Hazan U; Alcami J; Munier A; Arenzana-Seisdedos F; Bachelerie F; Israel A; Virelizier JL; Laboratoire d'Immunologie Virale, Institut Pasteur, Paris,; France.
We have investigated the effect of TNF, a cytokine produced during most immunologic and inflammatory reactions, on HIV genome expression in human T lymphocytes. A CD4+ human T cell line (J.Jhan) was transfected with vectors permitting the expression of the chloramphenicol acetyl transferase (CAT) gene under the contro
To find out whether systemic glutathione deficiency is associated with human immunodeficiency virus (HIV) infection, thus contributing to the immunodeficiency state, glutathione concentrations in venous plasma and lung epithelial lining fluid (ELF) of symptom-free HIV-seropositive and normal individuals were measured.
Lancet. 1989 Dec 9;2(8676):1351-4. Unique Identifier : AIDSLINE MED/90081086
Goedert JJ; Mendez H; Drummond JE; Robert-Guroff M; Minkoff HL; Holman S; Stevens R; Rubinstein A; Blattner WA; Willoughby A; et al; Viral Epidemiology Section, National Cancer Institute, Bethesda,; Maryland.
In a prospective study of pregnant women infected with human immunodeficiency virus type 1 (HIV-1) in Brooklyn, New York, USA, 16 (29%) of 55 evaluable infants were infected with HIV-1. 9 infants had paediatric acquired immunodeficiency syndrome, 6 had less severe clinical manifestations of HIV-1 infection, and 1 was
Lancet. 1989 Dec 16;2(8677):1442-4. Unique Identifier : AIDSLINE MED/90081156
Davison CF; Ades AE; Hudson CN; Peckham CS; Department of Paediatric Epidemiology, Institute of Child Health,; London.
Current policies on antenatal testing for human immunodeficiency virus (HIV) in the main obstetric units of the United Kingdom and the Republic of Ireland were surveyed by postal questionnaire; 294 o
Cloyd MW; Lynn WS; Ramsey K; Baron S; Department of Microbiology, University of Texas Medical Branch; Galveston 77550.
Details of the molecular interactions between human immunodeficiency virus (HIV-1) and its host cell during the infection process are not entirely clear. Building on recent reports by Lehr and Zimmer (1986, DMW 111, 1001-1002) that the membrane-reactive, anti-epileptic drug diphenylhydantoin (dilantin or phenytoin) (P
Bagasra O; Kajdacsy-Balla A; Lischner HW; Department of Microbiology, University of Medicine and Dentistry; of New Jersey-School of Osteopathic Medicine, Camden 08103-1505.
A role for the biological effects of alcohol is postulated in the increased risk of AIDS known to be associated with chronic alcohol abuse and alcohol consumption during sexual activity. In pilot experiments peripheral blood mononuclear cells from healthy volunteers were studied before and after a single ingestion of
Bull Cancer (Paris). 1989;76(7):729-32. Unique Identifier : AIDSLINE MED/90057724
Beuzeboc P; Quang TN; Flam TA; Zerbib M; Vellard P; Fenton J; Mathieu G; Boissonnas A; Institut Curie, Service de medecine oncologique, Paris, France.
Two homosexuals with advanced HIV infection and testicular seminoma stage IIb and IIc were treated with irradiation associated with chemotherapy in one patient. Subdiaphragmatic irradiation was followed by moderate diarrhoea. Initial chemotherapy consisted of cisplatinum, vinblastine, bleomycin replaced by cyclophosph
Cancer Lett. 1989 Nov 30;48(2):95-103. Unique Identifier : AIDSLINE MED/90058473
Tremblay M; Wainberg MA; Lady Davis Institute for Medical Research of the Sir Mortimer B.; Davis-Jewish General Hospital, Montreal, Quebec, Canada.
We have examined 3 different EBV-carrying B cell lines, in terms of ability to be super-infected by the human immunodeficiency virus (HIV-1), and have followed these lines, after infection by HIV-1, over a period of 3 months. We found significant variation among different HIV-1 strains in terms of the multiplicity of
EMBO J. 1989 Nov;8(11):3279-85. Unique Identifier : AIDSLINE MED/90059919
Barat C; Lullien V; Schatz O; Keith G; Nugeyre MT; Gruninger-Leitch F; Barre-Sinoussi F; LeGrice SF; Darlix JL; Labo-Retro Centre de Recherche de Biochimie et Genetique; Cellulaires du CNRS, Toulouse, France.
The virion cores of the replication competent type 1 human immunodeficiency virus (HIV-1), a retrovirus, contain and RNA genome associated with nucleocapsid (NC) and reverse transcriptase (RT p66/p51) molecules. In vitro reconstructions of these complexes with purified components show that NC is required for efficient
FEBS Lett. 1989 Nov 6;257(2):311-4. Unique Identifier : AIDSLINE MED/90060343
Schatz O; Cromme FV; Gruninger-Leitch F; Le Grice SF; Central Research Units, F. Hoffmann-LaRoche Ltd., Basel,; Switzerland.
Two single site substitutions (E478----Q and H539----F) were introduced into the C-terminal RNase H domain of HIV-1 reverse transcriptase. These mutant proteins were expressed in Escherichia coli and purified by Ni2+-nitrilotriacetic acid affinity chromatography. Both enzymes are clearly defective in RNase H function,
Berzofsky JA; Molecular Immunogenetics and Vaccine Research Section, National; Cancer Institute, Bethesda, Maryland 20892.
Immunodominant T-cell antigenic sites can so dominate a response that their presence leads to high responsiveness and their absence to low responsiveness. Therefore, it is important to locate such sites for vaccine development. Factors that lead to immunodominance include features extrinsic to the structure of the sit
J Immunol. 1989 Dec 1;143(11):3632-40. Unique Identifier : AIDSLINE MED/90063052
Ware RE; Scearce RM; Dietz MA; Starmer CF; Palker TJ; Haynes BF; Department of Medicine, Duke University Medical Center, Durham,; NC 27710.
The CD7 gp40 molecule is a member of the Ig gene superfamily and is expressed on T cell precursors before their entry into the thymus during fetal development. N-terminal amino acids 1-107 of CD7 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain of CD7 is proli
J Immunol. 1989 Dec 1;143(11):3737-42. Unique Identifier : AIDSLINE MED/90063068
Noguchi Y; Tateno M; Kondo N; Yoshiki T; Shida H; Nakayama E; Shiku H; Department of Oncology, Nagasaki University School of Medicine,; Japan.
T cell immune responses in syngeneic WKA/H rats were analyzed by using lymphoid cell lines, TARS-1, TART-1, and TARL-2, infected with human T-lymphotropic virus type 1 (HTLV-1). Spleen cells of rats in which these cell lines had been rejected were sensitized in vitro with the same cell lines, and cells cytotoxic to th
Webb PA; Happ CM; Maupin GO; Johnson BJ; Ou CY; Monath TP; Division of Vector-Borne Viral Diseases, Centers for Disease; Control, Fort Collins, Colorado 80522.
Human immunodeficiency virus (HIV) was detected in bedbugs (Cimex hemipterus) up to 8 d after oral exposure to highly concentrated virus in blood meals, but no virus replication was observed. HIV did not replicate in either intraabdominally inoculated bedbugs or intrathoracically inoculated mosquitoes (Toxorhynchites
Takahashi H; Houghten R; Putney SD; Margulies DH; Moss B; Germain RN; Berzofsky JA; Molecular Immunogenetics and Vaccine Research Section, National; Cancer Institute, Bethesda, Maryland 20892.
In H-2d mice, the immunodominant determinant of the HIV-1-IIIB gp160 envelope glycoprotein recognized by CD8+ CTL is represented by a 15-residue synthetic peptide (315-329: RIQRGPGRAFVTIGK). This peptide is seen in association with the Dd class I MHC molecule expressed on H-2k L cell fibroblast targets. We explored th
Spence RP; Jarvill WM; Ferns RB; Tedder RS; Parker D; Department of Molecular Biology, Wellcome Biotech, Beckenham,; Kent, U.K.
The sequences encoding the p24 core protein of human immunodeficiency virus type 1 were identified in a cDNA library made from infected CEM cells. The nucleotide sequence of the DNA coding for p24 was shown to be very similar but not identical to the sequences of lymphadenopathy virus and human T-cell leukaemia virus
The sequences coding for the p18 protein of CBL-1, a British human immunodeficiency virus (HIV) type 1 isolate, were expressed in Escherichia coli as beta-galactosidase fusion proteins. The recombinant proteins were used to screen a panel of five monoclonal antibodies (MAbs) raised against p18 expressed in CBL-1-infec
D'Aquila RT; Summers WC; Department of Internal Medicine, Yale University School of; Medicine, New Haven, Connecticut.
The human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT)/ribonuclease H has been expressed to high levels in Escherichia coli from a recombinant plasmid constructed using the polymerase chain reaction (PCR) for in vitro mutagenesis. Translational initiation and termination codons were introduced by t
Kunsch C; Hartle HT; Wigdahl B; Department of Microbiology and Immunology, Pennsylvania State; University, College of Medicine, Hershey 17033.
Human immunodeficiency virus type 1 (HIV-1) has been implicated in the generation of acquired immunodeficiency syndrome-associated neurological dysfunction, and it is believed that the presence of CD4 in the nervous system may be involved in the susceptibility of selected neural cell populations to HIV-1 infection. We
The reverse transcriptase (RT) activity of human immunodeficiency virus type 1 and other retroviruses is closely associated with a hybrid-degrading RNase H activity which is essential for retroviral replication. We have analyzed the effect of sulfated polysaccharides on human immunodeficiency virus type 1 recombinant
Berkhout B; Jeang KT; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892.
We have used site-directed mutagenesis to delineate sequence specific domains within the human immunodeficiency virus type 1 (HIV-1) trans-acting-responsive (TAR) RNA element that are required for trans activation by the viral Tat protein. Our data in part corroborate a recent report [S. Feng and E. C. Holland, Nature
Ment Retard. 1989 Aug;27(4):213-7. Unique Identifier : AIDSLINE MED/90066037
Diamond GW
The majority of children with symptomatic HIV infection present with a variety of neurodevelopmental impairments, including mental retardation and motor abnormalities. Their clinical courses vary widely, with some infants showing progressive deterioration during the first year of life whereas some children follow a st
Ment Retard. 1989 Aug;27(4):219-22. Unique Identifier : AIDSLINE MED/90066038
Hopkins KM
A population of young children is appearing with HIV infection of perinatal origin whose personal and family problems are complex. Most of their mothers are involved with intravenous drug abuse. The infants are in reasonable health for the first half year and then present with increasing medical and developmental prob
Ment Retard. 1989 Aug;27(4):223-5. Unique Identifier : AIDSLINE MED/90066039
Crocker AC
The significant developmental special needs of young children with congenital HIV infection require evaluation, training and education, therapy, and other supports. These services would usually be guided by developmentalists in a child study center, who are in close alliance with the medical, educational, and communit
Ment Retard. 1989 Aug;27(4):239-40. Unique Identifier : AIDSLINE MED/90066043
Spitzborg R
The special concerns of the child welfare community regarding pediatric HIV infection were described. These include appropriate use of foster care, preparation and commitment of personnel, and assurance of access to necessary services. There are both contrasts and common interests in work with this population between
Retrovirus particles, with an ultrastructure of type C-virus similar to HTLV-I were observed in several mid-term cultures of leukemic cells derived from a woman with a well characterised Sezary syndrome who had always resided in France . Reverse transcriptase activity was detected i
Res Virol. 1989 Sep-Oct;140(5):405-18. Unique Identifier : AIDSLINE MED/90069203
Goudsmit J; Bakker M; Smit L; Human Retrovirus Laboratory, Academic Medical Center, Amsterdam,; The Netherlands.
Chimpanzees infected with the HIV-1 strains HTLV-IIIB or LAV-1 in primary, secondary or tertiary passages developed neutralizing antibodies binding to variable domain V3 in the carboxyl terminal half of the external envelope (amino acids 309-317). Nonapeptide antigens reflecting either the HTLV-IIIB/LAV-1 neutralizati
Res Virol. 1989 Sep-Oct;140(5):419-36. Unique Identifier : AIDSLINE MED/90069204
Goudsmit J; Zwart G; Bakker M; Smit L; Back N; Epstein L; Kuiken C; d'Amaro J; de Wolf F; Human Retrovirus Laboratory, Academic Medical Center, Amsterdam,; The Netherlands.
Antibodies elicited by HIV-1 strains, and which neutralize such strains in vitro, bind to synthetic peptides of 5-8 amino acids in length. These amino acids, although variable, have a fixed location between two cysteines in the carboxyl terminus of the HIV-1 external envelope. Nine peptides of 9 amino acids correspond
Schweiz Med Wochenschr. 1989 Nov 4;119(44):1539-43. Unique Identifier : AIDSLINE MED/90069515
Ludwig CU; Onkologische Abteilung, Department fur Innere Medizin,; Kantonsspital Basel.
Only the recent production of large amounts of highly purified recombinant interferons has made it possible to elucidate precisely the in vitro and in vivo effect of alpha- and gamma-interferon. Interferon-alpha has significantly widened the treatment modalities for some rare tumors such as hairy cell leukemia and chr
Science. 1989 Dec 1;246(4934):1155-8. Unique Identifier : AIDSLINE MED/90069587
Larder BA; Kemp SD; Molecular Sciences Department, Wellcome Research Laboratories,; Beckenham, Kent, United Kingdom.
Human immunodeficiency virus (HIV) isolates with reduced sensitivity to zidovudine (3 -azido-3 -deoxythymidine, AZT ) from individuals with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex were studied to determine the genetic basis of
Twenty-five hybridomas of CMK series were generated which produced monoclonal antibodies (MCA) to human immunodeficiency virus (HIV). The MCA were shown to react with HIV antigenic determinants in enzyme-immunoassays to titres 5 X 10(3)--10(5). It was established by immunoblot that some MCA interact with HIV proteins
Wien Klin Wochenschr. 1989 Nov 10;101(21):738-40. Unique Identifier : AIDSLINE MED/90070696
Waldenberger FR; Furtwangler W; Oberwalder P; Cottogni M; I. Universitatsklinik fur Chirurgie, Innsbruck.
The risks of blood transfusion in context with the increasing number of operative open-heart procedures and the linked increased demand for blood products present a challenge to find methods of saving homologous blood. On the one hand there is increasingly less blood at the surgeon s disposal and on the other hand the
Eriksson BF; Chu CK; Schinazi RF; Veterans Administration Medical Center (Atlanta), Decatur,; Georgia 30033.
3 -Azido-2 ,3 -dideoxyuridine-5 -triphosphate was found to be a potent and highly selective inhibitor of human immunodeficiency virus type 1 and simian immunodeficiency virus reverse transcriptases. The affinity of 3 -azido-2 ,3 -dideoxyuridine-5 -triphosphate for the reverse transcriptases was similar to that observe
Jucowics P; Ramon ME; Don PC; Stone RK; Bamji M; Department of Dermatology, New York Medical College-Metropolitan; Hospital Center, NY 10029.
A 6-month-old infant with acquired immunodeficiency syndrome (AIDS) and typical scabies subsequently developed Norwegian scabies, with deterioration of clinical status. The infestation spread to several health care workers who were in close contact with the patient, despite standard isolation precautions. In the rapid
Biochem Biophys Res Commun. 1989 Nov 30;165(1):488-95. Unique Identifier : AIDSLINE MED/90073755
Matthes E; Lehmann C; von Janta-Lipinski M; Scholz D; Zentralinstitut fur Molecularbiologie, Akademe der Wissenchaften; der DDR, Berlin-Buch, GDR.
From a series of newly synthesized 3 -fluoro-modified nucleosides the C-5-chloro-substituted derivative of 2 ,3 -dideoxy-3 -fluorouridine (FddUrd) and the 4-thio analogue of 2 ,3 -dideoxy-3 -fluorothymidine (FddUrd) emerged as the most efficient and selective anti-HIV agents. Their antiviral doses (ED50) proved to be
AIDS Res Hum Retroviruses. 1989 Oct;5(5):479-86. Unique Identifier : AIDSLINE MED/90074394
Veronese FD; Rahman R; Kalyanaraman VS; Pal R; Lusso P; Tritch R; Petteway S; Gallo RC; Sarngadharan MG; Department of Cell Biology, Bionetics Research, Inc., Kensington,; MD 20895.
We report on the development of monoclonal antibodies directed against the transmembrane portion of the envelope of HTLV-III451 gp41. One of these monoclonal antibodies, designated M71/2B4, was found to cross-react with transmembrane proteins from other independent isolates of HIV-1, namely IIIB, MN, and RF. Thus, thi
AIDS Res Hum Retroviruses. 1989 Oct;5(5):487-93. Unique Identifier : AIDSLINE MED/90074395
Norrby E; Biberfeld G; Johnson PR; Parks DE; Houghten RA; Lerner RA; Department of Virology, Karolinska Institute, School of Medicine,; Stockholm, Sweden.
The advent of site-directed serology has provided a specific and simplified means of distinguishing antibody responses to the two types of human immunodeficiency virus (HIV) in an outbred population. Remarkably, human sera containing HIV antibodies and simian sera containing simian immunodeficiency virus (SIV) antibod
AIDS Res Hum Retroviruses. 1989 Oct;5(5):535-40. Unique Identifier : AIDSLINE MED/90074400
Wolfs TF; Geelen JL; Schellekens H; Barin F; Dekker JT; Goudsmit J; Department of Virology, Academic Medical Centre, University of; Amsterdam, The Netherlands.
The inhibition of HIV-1 and SIV reverse transcriptase by human and rhesus macaque serum positive for HIV-1 or HIV-2/SIV antibodies was studied. The domain to which reverse transcriptase-inhibiting antibodies were elicited appeared to be highly antigenic. A total of 67% (48 of 72) of individuals had HIV-1 reverse trans
Ohlin M; Broliden PA; Danielsson L; Wahren B; Rosen J; Jondal M; Borrebaeck CA; Department of Biotechnology, Lund University, Sweden.
Peripheral blood lymphocytes from healthy, HIV sero-negative blood donors have been in vitro immunized using penv9, a recombinant fragment of the envelope of HIV-1. This primary in vitro immunization followed by Epstein-Barr virus (EBV) transformation and somatic cell fusion subsequently gave rise to several specific
J Immunol. 1989 Dec 15;143(12):3967-75. Unique Identifier : AIDSLINE MED/90078997
Liou RS; Rosen EM; Fung MS; Sun WN; Sun C; Gordon W; Chang NT; Chang TW; Tanox Biosystems, Inc., Houston, TX 77025.
Murine mAb BAT123, which was made against the envelope glycoprotein gp120 of HTLV-IIIB strain of HIV type 1 (HIV-1), is capable of neutralizing HTLV-IIIB in vitro. It also inhibits the fusion between uninfected CD4+ cells and HIV-1-infected cells to form syncytia. As a step to explore the potential utility of the anti
Tsai CC; Yarnall M; Follis KE; Benveniste RE; Regional Primate Research Center, University of Washington,; Seattle 98195.
A rapid, sensitive and specific antigen capture (AC) assay has been established for the detection of p27 core protein of SAIDS type-D retrovirus (SRV). SRV p27 antigen in test samples was identified on rabbit anti-p27 IgG-coated microtiter plates by the addition of biotinylated rabbit anti-p27 IgG. This assay was spec
Proc Natl Acad Sci U S A. 1989 Dec;86(23):9514-8. Unique Identifier : AIDSLINE MED/90083298
Walker BD; Flexner C; Birch-Limberger K; Fisher L; Paradis TJ; Aldovini A; Young R; Moss B; Schooley RT; Infectious Disease Unit, Massachusetts General Hospital, Boston.
The definition of human immunodeficiency virus type 1 (HIV-1) immunogenic epitopes is central to the rational design of AIDS vaccine strategies. In this study, we have generated seven HIV-1 reverse transcriptase-specific cytotoxic T-lymphocyte (CTL) clones from the peripheral blood of two seropositive subjects. Epitop
Proc Natl Acad Sci U S A. 1989 Dec;86(23):9539-43. Unique Identifier : AIDSLINE MED/90083303
Berger EA; Clouse KA; Chaudhary VK; Chakrabarti S; FitzGerald DJ; Pastan I; Moss B; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20852.
We previously described an unusual recombinant protein, designated CD4(178)-PE40, containing the gp120 binding region of human CD4 linked to active regions of Pseudomonas exotoxin A. The ability of this molecule to selectively inhibit protein synthesis in cells expressing the surface envelope glycoprotein of human imm
Nishikawa K; Fukuhara N; Liprandi F; Green K; Kapikian AZ; Chanock RM; Gorziglia M; Laboratory of Infectious Diseases, National Institute of Allergy; and Infectious Diseases, Bethesda, Maryland 20892.
The complete VP4 gene of porcine rotavirus strain OSU has been inserted into a baculovirus expression vector under the control of the polyhedrin promoter. The VP4 outer capsid protein, which is a major neutralization antigen in rotavirus, was expressed in high yield in Spodoptera frugiperda cells. Reactivity with poly
Tadepalli SM; Quinn RP; Division of Experimental Therapy, Wellcome Research Laboratories,; Research Triangle Park, North Carolina 27709.
Two solid phase, nonradioactive immunoassays were developed and evaluated for the determination of zidovudine (Retrovir, ZDV, AZT ) concentrations in serum. The first, an enzyme-liked immunosorbent assay (ELISA), used an anti-AZT monoclonal antibody (M
Tartaglione TA; Holeman E; Opheim K; Smith T; Collier AC; Department of Pharmacy, University of Washington, Seattle.
Zidovudine (azidothymidine, AZT ) disposition was examined during a hemodialysis session in an HIV-infected male with mesangial proliferative glomerulonephritis. Serum concentrations of zidovudine and its glucuronidated inactive metabolite (G-ZDV) were
Atkinson JC; Yeh C; Oppenheim FG; Bermudez D; Baum BJ; Fox PC; Clinical Investigations and Patient Care Branch, National; Institute of Dental Research, Bethesda, Maryland 20892.
Thirty-seven HIV-1-positive patients contributed salivary samples from individual major salivary glands. Nineteen patients were unmedicated and asymptomatic, and 18 patients had developed signs of AIDS. Salivas from 15 healthy males served as controls. Levels of four salivary antimicrobial proteins (lactoferrin, lysoz
Rosenberg PS; Epidemiologic Methods Section, National Cancer Institute,; Rockville, Maryland 20892.
A simple noniterative method is presented for adjustment of AIDS surveillance data for reporting delays. The method estimates the distribution of reporting delays from a cross-classification of incident cases according to date of diagnosis vs. length of reporting delay. Using the delay distribution, the number of case
Kaplan EH; School of Organization and Management, Yale University, New; Haven, Connecticut 06520.
The simplest models of HIV infectivity treat the HIV transmission process as a series of independent Bernoulli trials over sex acts or sex partners. In this paper, an approximate maximum likelihood estimator of the transmission probability is derived for such models, and applied to two data sets. Nonparametric models
Wiktor SZ; Biggar RJ; Melbye M; Ebbesen P; Colclough G; DiGioia R; Sanchez WC; Grossman RJ; Goedert JJ; Viral Epidemiology Section, National Cancer Institute, Bethesda,; Maryland 20892.
One hundred thirty-four homosexual men from a prospective cohort study of AIDS risk from New York City and Washington D.C. and 139 homosexual men from a similar cohort in Copenhagen and Aarhus, Denmark were questioned regarding thei
Chiasson MA; Stoneburner RL; Joseph SC; AIDS Research Unit, New York City Department of Health, New York; 10013.
Six human immunodeficiency virus type 1 (HIV-1) seropositive semen donors were identified during an antibody screening program initiated at an artificial insemination clinic in New York City in 1985. A total of 176 women underwent artificial insemination with fresh semen from these six donors between 1978 and mid-1985
Hira SK; Nkowane BM; Kamanga J; Wadhawan D; Kavindele D; Macuacua R; Mpoko G; Malek M; Cruess DF; Perine PL; School of Medicine, University of Zambia.
Persons living in the same household as index patients with AIDS or ARC in Lusaka, Zambia were clinically and serologically evaluated for HIV-1 infection. In the 150 households of male index cases, 92 (61.3%) of their spouses were infected, compared with 57 (73.1%) of the spouses o
Hira SK; Ngandu N; Wadhawan D; Nkowne B; Baboo KS; Macuacua R; Kamanga J; Mpoko B; Heiba IM; Perine PL; School of Medicine, University of Zambia.
Among 1,350 patients with serologically confirmed HIV-1 infection evaluated at the Dermatovenerealogy Clinic, University Teaching Hospital. Lusaka, through March 1987, 125 (9.3%) had AIDS, 1,178 (87.3%) had AIDS-related complex, and 46 (3.5%) were asymptomatic. The male to female ratio of cases was 1.5:1 and women wer
Chesebro B; Buller R; Portis J; Wehrly K; National Institute of Allergy and Infectious Diseases, Rocky; Mountain Laboratories, Hamilton, Montana 59840.
CD4 molecules on human cells function as a major receptor for human immunodeficiency virus (HIV); however, certain CD4-negative cell types may also be susceptible to infection. Therefore, we attempted to quantitate the relationship between HIV infection and CD4 expression on human cell lines before and after introduct
Lilienbaum A; Duc Dodon M; Alexandre C; Gazzolo L; Paulin D; Universite Paris 7, Institut Pasteur, France.
We report that the expression of the vimentin gene, a cytoskeletal growth-regulated gene, is activated in trans by the Tax (p40x) transactivator protein encoded by the human T-cell leukemia virus type I. Expression of the Tax protein activates a number of cellular genes, such as those coding for the alpha chain of the
Shibata R; Miura T; Hayami M; Sakai H; Ogawa K; Kiyomasu T; Ishimoto A; Adachi A; Department of Viral Oncology, Kyoto University, Japan.
We constructed a full-length molecular clone of simian immunodeficiency virus from an African green monkey. Upon transfection, this clone directed the production of virus particles cytopathic and infectious to human CD4+ leukemia cell lines. Mutations were introduced by recombinant DNA techniques into eight open readi
JAMA. 1990 Jan 5;263(1):60-4. Unique Identifier : AIDSLINE MED/90080195
Khabbaz RF; Darrow WW; Hartley TM; Witte J; Cohen JB; French J; Gill PS; Potterat J; Sikes RK; Reich R; et al; Division of Viral Diseases, Centers for Disease Control, Atlanta,; Ga 30333.
We tested 1305 female prostitutes from eight areas of the United States for antibodies to human T-cell lymphotropic virus type I/II. Overall, 6.7% were human T-cell lymphotropic virus type I/II seropositive (with antibodies to both gag and env gene products). The seroprevalence rates r
Am J Psychiatry. 1990 Jan;147(1):89-93. Unique Identifier : AIDSLINE MED/90087143
Perry S; Jacobsberg LB; Fishman B; Frances A; Bobo J; Jacobsberg BK; Department of Psychiatry, Cornell University Medical College, New; York Hospital, NY 10021.
To identify the diagnostic characteristics and counseling needs of individuals at risk for acquired immune deficiency syndrome (AIDS), standardized DSM-III-R diagnoses were given to 207 physically asymptomatic adults when they sought serological testing for the human immunodeficiency virus (HIV). The subjects had high
Am J Public Health. 1990 Jan;80(1):54-6. Unique Identifier : AIDSLINE MED/90087159
Marchetti AG; Nathanson RS; Kastner TA; Owens R; Developmental Disability Center, Morristown Memorial Hospital, NJ; 07960.
A survey of state developmental disability agencies was undertaken in October 1987 regarding AIDS policy development, education, and training and service provision. Of 44 states responding to the 27-item questionnaire, only 21 had formal AIDS policies. Policies varied considerably from state to state. Twenty-five of t
Am J Public Health. 1990 Jan;80(1):82-4. Unique Identifier : AIDSLINE MED/90087169
Magura S; Shapiro JL; Siddiqi Q; Lipton DS; Narcotic and Drug Research, Inc., New York, NY 10013.
Correlates of condom use were identified using cross-sectional data from a convenience sample of 211 sexually active intravenous drug users enrolled in methadone maintenance in New York City. Sixty-eight percent did not use condoms at all in the previous month and only 11 percent used condoms every time. Nineteen perc
Perez G; Ortiz-Interian C; Bourgoignie JJ; Lee H; de Medina M; Allain JP; Schiff E; Parks E; Roth D; Milgrom M; et al; Department of Medicine, University of Miami School of Medicine,; FL 33101.
The prevalence of retroviral infection in renal transplantation remains poorly defined. We tested retrospectively sera from 224 of 331 patients undergoing renal transplantation between 1979 and 1985. Viral antigen based EIA was used for screening IgG antibodies to human immunodeficiency virus (HIV-I) and human T-cell
Ann Intern Med. 1990 Jan 1;112(1):35-49. Unique Identifier : AIDSLINE MED/90087506
Glassock RJ; Cohen AH; Danovitch G; Parsa KP; Department of Medicine, Harbor-UCLA Medical Center, Torrance; 90509.
Since the first report on the acquired immunodeficiency syndrome (AIDS) in 1981, organ involvement of AIDS has increased. We discuss the effect of human immunodeficiency virus (HIV) infection, the causative agent of AIDS, on the field of nephrology. Hyponatremia, the commonest fluid and electrolyte abnormality, is cau
Cohen EA; Terwilliger EF; Jalinoos Y; Proulx J; Sodroski JG; Haseltine WA; Department of Human Retrovirology, Dana-Farber Cancer Institute,; Harvard Medical School, Massachusetts 02115.
To investigate the role of vpr (viral protein R) in the replication and cytopathicity of human immunodeficiency virus type 1 (HIV-1), infectious proviruses were constructed that were isogenic except for the ability to produce the protein product of vpr. The experiments described here demonstrate that vpr encodes a 96
Ann Intern Med. 1990 Jan 1;112(1):3-10. Unique Identifier : AIDSLINE MED/90087505
Itescu S; Brancato LJ; Buxbaum J; Gregersen PK; Rizk CC; Croxson TS; Solomon GE; Winchester R; New York University Medical Center, New York.
STUDY OBJECTIVE: To describe the clinical, immunologic, and immunogenetic features of a diffuse infiltrative lymphocytic disorder resembling Sjogren syndrome in persons infected with human immunodeficiency virus (HIV). DESIGN: Clinical case study. SETTING: University-affiliated hospitals and outpatient clinics. PATIEN
In a previous paper, we determined that treatment of lymphocytes with nonviable preparations of human immunodeficiency virus type 1 (HIV-1) results in an impairment of the phosphatidylinositol/protein kinase C pathway, most likely due to an inhibition of the cleavage of phosphatidylinositol bisphosphate into inositol
Gustavson LE; Fukuda EK; Rubio FA; Dunton AW; Department of Drug Metabolism, Hoffmann-La Roche Inc., Nutley, NJ; 07110.
Eight patients with AIDS or ARC received four single doses of 2 ,3 -dideoxycytidine ( ddC ). The treatments included 0.5 and 5 mg oral tablets, a 0.5 mg oral solution, and a 0.5 mg intravenous infusion. Blood samples were collected for 4 to 6 h after ea
Selik RM; Buehler JW; Karon JM; Chamberland ME; Berkelman RL; AIDS Program, Centers for Disease Control, Atlanta, Georgia.
To measure the impact of the 1987 expansion of the definition of acquired immune deficiency syndrome on the number and characteristics of cases in the United States , we reviewed the 28,920 cases diagnosed since the revision and reported through 1988. The proportion meeting only new cri
Montefiori DC; Robinson WE Jr; Hirsch VM; Modliszewski A; Mitchell WM; Johnson PR; Department of Pathology, School of Medicine, Vanderbilt; University, Nashville, Tennessee 37232.
Plasma from two rhesus macaques (Macaca mulatta) experimentally infected with the simian immunodeficiency virus (SIV; isolate SIVmac251) enhanced SIVmac infection of a human CD4+ lymphoblastoid cell line, MT-2. Prechallenge plasma samples from these animals and serum from SIV-negative macaques did not enhance infectio
Uhnoo I; Riepenhoff-Talty M; Dharakul T; Chegas P; Fisher JE; Greenberg HB; Ogra PL; Department of Pediatrics, School of Medicine, State University of; New York, Buffalo.
The pathogenic profiles of two heterologous animal rotaviruses, rhesus rotavirus strain MMU 18006 and bovine rotavirus strain WC3, were evaluated in mice with severe combined immunodeficiency (SCID mice) and normal BALB/c mice. Control animals were inoculated with homologous murine strain EDIM 5099 or a tissue culture
Patton DF; Shirley P; Raab-Traub N; Resnick L; Sixbey JW; Department of Hematology/Oncology, St Jude Children's Research; Hospital, Memphis, Tennessee.
Defective Epstein-Barr virus (EBV) has a deleted and rearranged genome (termed het DNA) that disrupts latency and induces standard EBV to replicate in vitro. We used the polymerase chain reaction to detect, in 2 of 10 patient samples, the junction of abnormally juxtaposed EBV DNA fragments BamHI W and Z, a genomic rea
Mergia A; Shaw KE; Lackner JE; Luciw PA; Department of Pathology, School of Medicine, University of; California, Davis 95616.
We have molecularly cloned and sequenced a portion of the simian foamy virus type 1 (SFV-1); open reading frames representing the endonuclease domain of the polymerase (pol) and the envelope (env) genes were identified by comparison with the human foamy virus (HFV). Unlike the HFV genomic organization, the SFV-1 pol g
Rasty S; Dhruva BR; Schiltz RL; Shih DS; Issel CJ; Montelaro RC; Department of Biochemistry, Louisiana State University, Baton; Rouge.
The structure and integration patterns of equine infectious anemia virus (EIAV) proviral DNA and the patterns of viral transcription were examined in persistent and cytopathic infections of cultured cells. The results of Southern blot analyses indicated that, in persistently infected cells, about 30% of the EIAV provi
Brundage JF; McNeil JG; Miller RN; Gardner LI Jr; Harrison SM; Hawkes C; Craig DB; Redfield R; Burke DS; Hawks C/[corrected to Hawkes C]; Division of Preventive Medicine, Walter Reed Army Institute of; Research, Washington, D.C. 20307-5100.
North Eastern Reporter, 2d Series. 1988 Nov 16 (date of decision);530:168-173. Unique Identifier : AIDSLINE KIE/28927
The Supreme Judicial Court of Massachusetts held that the Commissioner of Insurance had no statutory authority, expressed or implied, to promulgate regulations prohibiting or restricting underwritng practices of insurance companies regarding the testing of prospective insurees for exposure to the AIDS virus. The Court
Federal Reporter, 2d Series. 1988 Aug 25 (date of decision);855:536-541. Unique Identifier : AIDSLINE KIE/29092
U.S. Court of Appeals EC
The U.S. Court of Appeals, Eighth Circuit, affirmed the dismissal without prejudice of an inmate s civil rights action seeking injunctive relief and damages for the failure of Arkansas prison authorities to protect inmates from exposure to the AIDS virus. The Court found no indication that the prison authorities were
Pacific Reporter, 2d Series. 1988 Nov 28 (date of decision);763:1003-1020. Unique Identifier : AIDSLINE KIE/28958
A patient who received a unit of HIV-contaminated blood from Belle Bonfils Memorial Blood Center sued Belle Bonfils for negligently screening the donation and sought disclosure of donor records. Information provided by the Center did not disclose donor identification. The trial court ordered the Center to produce the
Federal Supplement. 1988 Sep 29 (date of decision);701:717-726. Unique Identifier : AIDSLINE KIE/29094
The U.S. District Court for the Western District of Missouri entered a summary judgment in favor of AIDS patients who were eligible for Medicaid, requiring Medicaid reimbursement for the drug AZT . Missouri law, patterned after
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