1992

A:World united against AIDS. [videorecording].: Geneva, Switzerland : World Health Organization, [1988] 1 videocassette (21 min.) : sd., col. with b&w ; 1/2 in Unique Identifier : AIDSLINE AV/9200958A
Finding our way together. [videorecording]: [United States] : Rain Country Video, c1989 1 videocassette (28 min.) : sd., col. ; 1/2 in. + 1 leaflet Unique Identifier : AIDSLINE AV/9200941A; (Producer) People with AIDS and their caregivers discuss the special needs they have in dealing with AIDS. Two essential points are underscored: that caregivers also need caregivers, so that they can be strong, and that health should always be emphasized over sickness.
A:Right to care : help and health services for people with HIV/AIDS. [videorecording]: [Albany, N.Y.?] : The Department, c1990 1 videocassette (21 min.) : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/9200907A; (Producer) This video explores the legal rights to health care in New York State for people with HIV or AIDS. Brief vignettes illustrate and discuss possible forms of discrimination against people with HIV/AIDS.
Gastrointestinal manifestations of AIDS : recorded at DDW 1990, San Antonio. [sound recording]: [Thorofare, N.J.] : American Gastroenterological Association, c1990 2 sound cassettes (ca. 105 min.) : analog (AGA clinical symposium) Unique Identifier : AIDSLINE AV/9200942A
Communicable disease control. [videorecording]: Naples, Fla. : ASVP, c1991 1 videocassette (ca. 28 min.) : sd., col. ; 1/2 in (Hands on skills series) Unique Identifier : AIDSLINE AV/9200866A; West KH; (Producer) Essential for all pre-hospital care providers, this program provides important information on communicable diseases such as Hepatitis, Hepatitis Non-A and Non-B, HIV, and childhood diseases that can spread from patient to rescuer, from care provider to care provider, or from your last patient to your next
AIDS, every day precautions for healthcare workers : video update. [videorecording]: Mount Kisco, N.Y. : Guidance Associates, 1992 1 videocassette (37 min.) : sd., col. ; 1/2 in. + 1 guide Unique Identifier : AIDSLINE AV/9200885A; Alpert LI; Committee
[AIDS o shiru.]: Tokyo : Kodansha, 1983 viii, 166, 15 p. : ill Unique Identifier : AIDSLINE CAT/9209700; Nishioka K
AIDS and adolescents : the time for prevention is now.: Washington, DC : Center for Population Options, [1987] 24 p Unique Identifier : AIDSLINE CAT/9209211; Haffner D
AIDS legal guide. 2nd ed., completely rev. and expanded.: New York, NY (666 Broadway, New York 10012) : Lambda Legal Defense and Education Fund, c1987 1 v. (various pagings) Unique Identifier : AIDSLINE CAT/9208835; Rubenfeld AR
[AIDS geht jeden an : Ergebnisse der Internationalen AIDS-Tagung im November 1986 in Berlin.]: Berlin : Kulturbuch, [1987] 92 p Unique Identifier : AIDSLINE CAT/9208463
[Solidaritat der Uneinsichtigen : Aktionstag 9. Juli 1988, Frankfurt a.M. : eine Dokumentation der Reden.]: Berlin : Deutsche AIDS-Hilfe, 1988 64 p. : ill (AIDS-Forum D.A.H. Sonderband) Unique Identifier : AIDSLINE CAT/9209992; Becker F
[SIDA : actualidades.]: Madrid : Biolecta, [1988?] 76 p. : ill (Publicaciones cientificas / Asociacion Espanola de Biopatologia Clinica) Unique Identifier : AIDSLINE CAT/9209599
AIDS : helping families cope : recommendations for meeting the psychosocial needs of persons with AIDS and their families : report to the National Institute of Mental Health, November 1987.: [Silver Spring, Md. : National Association of Social Workers, 1988] 10 p Unique Identifier : AIDSLINE CAT/9209702; Zlotnik JL
AIDS : the women. 1st ed.: San Francisco : Cleis Press, c1988 251 p Unique Identifier : AIDSLINE CAT/9209213; Rieder I; Ruppelt P
Policy guidelines for addressing HIV infection in the academic medical community : a report of the AAMC Committee on AIDS and the Academic Medical Center.: Washington, D.C. (One Dupont Circle, N.W., Washington 20036) : Association of American Medical Colleges, c1988 vii, 33 p Unique Identifier : AIDSLINE CAT/9209048
[AIDS und Jugendhilfe : jugendhilfe- und sozialrechtliche Situation.]: Berlin : Arbeitskreis zur Forderung von Pflegekindern, c1989 152 p Unique Identifier : AIDSLINE CAT/9209701; Munder J
Blood issues update : minimizing the risk of transfusion-associated HIV infection.: Blood Resources [Chicago, Ill.] : American Hospital Association, [c1989] 14 p (Hospital technology series. Special report, ISSN 0888-711X ; v. 3, no. 21 (Aug. 1989)) Unique Identifier : AIDSLINE CAT/9208844
AIDS and drug use : breaking the link.: New York, N.Y. : Citizens Commission on AIDS for New York City and Northern New Jersey, 1989 53 p Unique Identifier : AIDSLINE CAT/9209212
Building systems of care for children with HIV infection & their families, August 1989.: Development. Office of Maternal and Child Health Washington, DC : Association for the Care of Children's Health, c1989 19 p Unique Identifier : AIDSLINE CAT/9209726
[Materialien aus den Einrichtungen des Modells Betreuung und Beratung HIV-infizierter Drogenabhangiger an Drogenberatungsstellen : Konzeptionsbeschreibungen = Conceptions of AIDS-counseling in outpatient treatment centers.]: Munchen : Institut fur Therapieforschung, 1989 301 p. : ill (IFT-Berichte ; Bd. 51) Unique Identifier : AIDSLINE CAT/9209464; Schumann J
Research in perinatal medicine II : an interdisciplinary approach with special emphasis on epidemiology, hypoxia, and infections. 1. Aufl.: Berlin : Verlag Gesundheit, c1990- v. : ill Unique Identifier : AIDSLINE CAT/9209077; Grauel EL
Client satisfaction with inpatient and outpatient HIV/AIDS services in New South Wales.: [Sydney : The Bureau], 1990 51 p (State health publication ; no. (AIDS) 90-42) Unique Identifier : AIDSLINE CAT/9208882; Linder-Pelz S
AIDS education videotapes : an annotated bibliography for NADR project staff.: Rockville, Md. (5600 Fishers Lane, Room 9A-30, Rockville, 20857) : National Institute on Drug Abuse ; Bethesda, Md. (4600 East-West Highway, Suite 700, Bethesda, 20814) : NOVA Research Company, [1990] 85 p Unique Identifier : AIDSLINE CAT/9208834; Joseph L; Bentley S
[Leben und Sterben mit AIDS : Gesprache mit Patienten im Krankenhaus.]: Frankfurt/Main : VAS, c1990 214 p. : ill Unique Identifier : AIDSLINE CAT/9208626; Knupp B
AIDS law for mental health professionals : a handbook for judicious practice.: San Francisco, Calif. ; Berkeley, Calif. : AIDS Health Project : Distributed to the trade by Celestial Arts, c1990 xvii, 245 p Unique Identifier : AIDSLINE CAT/9208464; Wood GJ; Marks R; Dilley JW
Productive living strategies for people with AIDS.: New York : Haworth Press, 1990 227 p (Occupational therapy in health care, ISSN 0738-0577 ; v. 7, no. 2-4) Unique Identifier : AIDSLINE CAT/9208699; Johnson JA; Pizzi M
Culture and AIDS.: New York : Praeger, 1990 vi, 216 p Unique Identifier : AIDSLINE CAT/9208523; Feldman DA
The:Guide to resources on women and AIDS. Began in 1990.: Washington, DC : Center for Women Policy Studies, v Unique Identifier : AIDSLINE CAT/9208935
[Sexualerziehung als AIDS-Pravention : Arbeitsformen und Erfahrungen aus der Jugend- und Bildungsarbeit.]: Weinheim : Juventa, 1991 180 p Unique Identifier : AIDSLINE CAT/9209569; Stickelmann B
[Transfusion sanguine et SIDA.]: Paris : Editions Frison-Roche, c1991 78 p. : ill (Les Monographies de la Societe nationale de transfusion sanguine) Unique Identifier : AIDSLINE CAT/9209616; Lefrere J
[Tourismus, Prostitution, Aids.] 1. Aufl.: Zurich : Rotpunktverlag, 1991 146 p. : ill (Kleine Reihe Tourismus & Entwicklung ; Bd. 5) Unique Identifier : AIDSLINE CAT/9208773; Maurer M
[AIDSbekampfung in der Bundesrepublik Deutschland.] Aktualisierte 3. Aufl.: Bonn : Bundesministerium fur Gesundheit, 1991 99 p. : ill., ports (Das Bundesgesundheitsministerium informiert) Unique Identifier : AIDSLINE CAT/9208465
AIDS & HIV education : effective teaching strategies.: Portland, Me. (P.O. Box 658, Portland, 04104-0658) : J. Weston Walch, c1991 xvii, 153 p. : ill Unique Identifier : AIDSLINE CAT/9208462; Firkaly ST
AIDS, a strategy for nursing care. 3rd ed.: London : Arnold, 1991 viii, 279 p Unique Identifier : AIDSLINE CAT/9208836; Pratt RJ
National AIDS Clearinghouse conference calendar : a service of the Centers for Disease Control, National AIDS Information and Education Program. July 1991-: Rockville, Md. : The Clearinghouse, [1991- v Unique Identifier : AIDSLINE CAT/9208658
AIDS : prevention through education : a world view.: New York : Oxford University Press, 1992 382 p. : ill Unique Identifier : AIDSLINE CAT/9209703; Sepulveda Amor J; Fineberg HV; Mann JM
The:essential HIV treatment fact book.: New York : Pocket Books, c1992 xvi, 448 p. : ill Unique Identifier : AIDSLINE CAT/9208426; Pinsky L; Douglas PH; Metroka C
Families living with drugs and HIV : intervention and treatment strategies.: New York : Guilford Press, c1993 xvi, 368 p Unique Identifier : AIDSLINE CAT/9208549; Barth RP; Pietrzak J; Ramler M
SCRIPPS MEMORIAL HOSPITALS FOURTEENTH ANNUAL CANCER SYMPOSIUM. OCTOBER 22-24, 1990, LA JOLLA, CA: Scripps Memorial Hospitals Fourteenth Annual Cancer Symposium. October 22-24, 1990, La Jolla, CA, Thomas T Stevens Cancer Center of Scripps Memorial Hospitals, 264 p., 1990.. Unique Identifier : AIDSLINE ICDB/92680731; Anonymous; No affiliation given; The Scripps Memorial Hospitals Fourteenth Annual Cancer Symposium was held October 22-24, 1990, in La Jolla, CA. The five major sessions focused on hematology, evolution of multimodality therapy in gastrointestinal cancer, gynecological cancer, issues for the 1990s, breast cancer and AIDS. The following subjects were
RETROVIRAL ENV-MEDIATED LEUKEMOGENESIS (MEETING ABSTRACT): Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Diseases. October 6-11, 1991, Padova/Venice, Italy, p. 3, 1991.. Unique Identifier : AIDSLINE ICDB/92682362; Amanuma H; Watanabe N; Ikawa Y; Tsukuba Life Science Center, RIKEN, Tsukuba, Ibaraki 305, Japan; Friend spleen focus-forming virus (SFFV), originally isolated as one of the components of the Friend virus complex, is a member of the murine replication-defective type C retroviruses and induces acute, progressive erythroleukemia, called Friend disease, in adult mice. In the early stage, enhanced polyclonal prolifera
FACTORS IN THE DEVELOPMENT OF AIDS-RELATED LYMPHOMAS (MEETING ABSTRACT): Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Diseases. October 6-11, 1991, Padova/Venice, Italy, p. 9, 1991.. Unique Identifier : AIDSLINE ICDB/92682367; Broder S; NCI, Bethesda, MD; The association between AIDS and a spectrum of malignancies relates to chronic, profound defects in both cellular and humoral mechanisms of immune surveillance. Furthermore, viruses in addition to HIV may act directly or indirectly as cofactors to induce malignant transformation. As AIDS patients (pts) live longer i
ONCOGENES AND TUMOR-SUPPRESSOR GENES IN B-CELL LYMPHOMA PATHOGENESIS (MEETING ABSTRACT): Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Diseases. October 6-11, 1991, Padova/Venice, Italy, p. 13, 1991.. Unique Identifier : AIDSLINE ICDB/92682369; Dalla-Favera R; Dept. of Pathology, Coll. of Physicians and Surgeons, Columbia; Univ., New York, NY 10032; A group of B-cell malignancies including Burkitt s lymphoma (BL), L3-type acute lymphoblastic leukemia (ALL) and AIDS-associated non-Hodgkin s lymphoma (AIDS-NHL) are associated with specific chromosomal translocations involving the c-myc and immunoglobulin loci. The consequences o
MORPHOLOGICAL AND PHENOTYPICAL CHANGES IN EBV-POSITIVE LYMPHOBLASTOID CELLS INFECTED BY HIV-1 (MEETING ABSTRACT): Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Diseases. October 6-11, 1991, Padova/Venice, Italy, p. 14, 1991.. Unique Identifier : AIDSLINE ICDB/92682370; De Rossi A; Calabro ML; D'Andrea E; Panozzo M; Saggioro D; Mammano F; Gallo P; Roncella S; Ferrarini M; Chieco-Bianchi L; Inst. of Oncology, Univ. of Padova, Padova, Italy; To study the mode of HIV-1 infection in EBV-positive lymphoblastoid cell lines (LCLs), as well as the molecular and biological features of EBV- and HIV-1-infected B cells, 3 spontaneous LCLs from HIV-1 seropositive individuals and 2 LCLs derived in vitro by infection with supernatant from the B95.8 marmoset cell line,
CHARACTERIZATION OF C-TERMINAL TRUNCATIONS OF MOLONEY MULV PR65GAG (MEETING ABSTRACT): Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Diseases. October 6-11, 1991, Padova/Venice, Italy, p. 20, 1991.. Unique Identifier : AIDSLINE ICDB/92682376; Ernst S; Gorelick R; Rein A; Lab. of Molecular Virology and Carcinogenesis, ABL-Basic Res.; Program, Frederick, MD 21702; In an attempt to define functional domains of the gag precursor in Moloney MuLV, we have generated a number of mutants in the gag gene of an infectious molecular clone of this virus. We introduced a series of termination codons at different points in the p30ca and p10nc coding regions. Mammalian cells were transfected
HTLV-I TAX: ASSOCIATION WITH VIRUS TRANSMISSION AND LEUKEMOGENESIS (MEETING ABSTRACT): Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Diseases. October 6-11, 1991, Padova/Venice, Italy, p. 21, 1991.. Unique Identifier : AIDSLINE ICDB/92682377; Essex M; Korber B; Okayama A; Chen Y; Renjifo B; Lee TH; Tachibana N; Marlink R; Dept. of Cancer Biology, Harvard Sch. of Public Health, Boston,; MA 02115; The vast majority of HTLV-I-infected individuals make antibodies to the virus structural proteins, especially the env gene products gp46 and gp21. The high frequency with which these antibodies are detected facilitate blood antibody screening with a high degree of success. A smaller but distinct fraction of HTLV-I-inf
LYMPHOMA, AN OPPORTUNISTIC NEOPLASIA OF AIDS: A MULTIPARAMETER STUDY OF 111 CASES (MEETING ABSTRACT): Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Disease. October 6-11, 1991, Padova/Venice, Italy, p. 37, 1991.. Unique Identifier : AIDSLINE ICDB/92682393; Ioachim HL; Dept. of Pathology, Lenox Hill Hosp., New York, NY; The incidence of lymphomas in HIV-infected persons has increased progressively since the beginning of the AIDS epidemic. In the United States there were, by 1989, 3000 cases of AIDS-associated non-Hodgkin s lymphomas (NHL) out of 100,000 cases of AIDS, an incidence of 3%, 60 times high
RETROVIRUS-INDUCED MURINE LYMPHOMA AND PARANEOPLASTIC SYNDROMES (MEETING ABSTRACT): Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Disease. October 6-11, 1991, Padova/Venice, Italy, p. 42, 1991.. Unique Identifier : AIDSLINE ICDB/92682397; Jolicoeur P; Kay DG; Simard C; Huang M; Clinical Res. Inst. of Montreal, Montreal, Canada; Murine AIDS (MAIDS) shows many similarities with human AIDS. The etiologic agent of MAIDS is a defective retrovirus encoding a precursor gag protein (Pr60gag) which remains uncleaved. Helper-free stocks of this defective virus have been shown to induce disease. Using such helper-free stocks, we have found that the inf
GEOGRAPHY MORE THAN PATHOLOGY INFLUENCES THE LIMITED HTLV-I GENOMIC VARIABILITY (MEETING ABSTRACT): Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Disease. October 6-11, 1991, Padova/Venice, Italy, p. 46, 1991.. Unique Identifier : AIDSLINE ICDB/92682398; Komurian F; Pelloquin F; Sonoda S; De The G; Pasteur Merieux, Marcy L'Etoile, France; In order to study the geographic and/or disease-associated variations of the HTLV-I genome, the ex-vivo DNA from seropositive peripheral blood lymphocytes of 4 Japanese patients (pts; 2 with tropical spastic paraparesis/HTLV-1 associated myelopathy [TSP/HAM] and 2 with adult T-cell leukemia [ATL]), 3 Caribbean pts (2
EXPRESSION AND BIOLOGICAL FUNCTION OF HUMAN ENDOGENOUS RETROVIRAL SEQUENCES (MEETING ABSTRACT): Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Disease. October 6-11, 1991, Padova/Venice, Italy, p. 48, 1991.. Unique Identifier : AIDSLINE ICDB/92682399; Leib-Mosch C; Bachmann M; Brack-Werver R; Werner T; Erfle V; Hehlmann R; III Medizinische Klinik Mannheim der Universitat Heidelberg,; Wiesbadener Str. 7-11, D-6800 Mannheim 31, Germany; The human genome contains a variety of retroviral elements resembling mammalian leukemia viruses. Most of these sequences have been found to be related to primate and murine C-type viruses (BaEV, SSAV/GaLV, MuLV), to murine B-type viruses and A-type particles (MMTV, IAP), or to human T-cell lymphotropic viruses (HTLV)
THE EPIDEMIOLOGY OF HUMAN VIRUS-ASSOCIATED HEMATOLOGIC MALIGNANCIES (MEETING ABSTRACT): Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Disease. October 6-11, 1991, Padova/Venice, Italy, p. 49, 1991.. Unique Identifier : AIDSLINE ICDB/92682400; Levine PH; Blattner WA; Viral Epidemiology Section, NCI, Bethesda, MD; The long history of virus-induced hematologic malignancies in a variety of animals strongly suggested that viruses would also be implicated in the etiology of human leukemia and lymphoma. Considerable clinical, epidemiologic and laboratory evidence links two viruses, Epstein-Barr virus (EBV) and human T-cell lymphotro
HTLV-I AS AGENT INDUCING GENETIC CHANGES IN INFECTED HUMAN LYMPHOCYTES (MEETING ABSTRACT): Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Disease. October 6-11, 1991, Padova/Venice, Italy, p. 54, 1991.. Unique Identifier : AIDSLINE ICDB/92682404; Maruyama K; Fukushima T; Mochizuki S; Kawamura K; Miyauchi M; Dept. of Pathology, Chiba Cancer Center Res. Inst., Chiba 280,; Japan; HTLV-I is etiologically associated with adult T-cell leukemia (ATL). However, the relative low incidence of ATL among virus carriers in ATL-endemic areas suggests host and/or environmental cofactors for the development of ATL. In a search for host cofactors, members in 3 generations of a suspected carrier family were
DIDEOXYNUCLEOSIDES AS SPECIFIC ANTILEUKEMIC AGENTS IN LYMPHOBLASTIC DISEASE (MEETING ABSTRACT): Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Disease. October 6-11, 1991, Padova/Venice, Italy, p. 55, 1991.. Unique Identifier : AIDSLINE ICDB/92682405; McCaffrey RP; Torres ER; Cronin K; Safran H; Dhawan R; Boston Univ. Medical Center, Boston, MA; Intense interest is now focused on the biological activity of 2 ,3 -dideoxynucleosides (ddNs) since their introduction as antiretroviral agents in HIV-infected individuals. We have noted that the lymphoblastic leukemia-associated DNA polymerase, terminal deoxynucleotidyl transferase (TdT), like HIV reverse transcripta
STUDIES ON THE MECHANISMS OF HTLV-I LEUKEMOGENESIS (MEETING ABSTRACT): Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Diseases. October 6-11, 1991, Padova/Venice, Italy, p. 82, 1991.. Unique Identifier : AIDSLINE ICDB/92682422; Saggioro D; Forino M; Chieco-Bianchi L; Inst. of Oncology, Univ. of Padova, Padova, Italy; Human T-lymphotropic virus type I (HTLV-I) gene expression in vivo and in vitro is quite restricted, even if HTLV-I LTR promoter/enhancer sequences are susceptible to different cellular and viral stimuli. The mechanisms of viral latency remain to be elucidated, but it is believed that host cellular factors are involve
NATURAL HYBRIDOMAS (MEETING ABSTRACT): Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Diseases. October 6-11, 1991, Padova/Venice, Italy, p. 88, 1991.. Unique Identifier : AIDSLINE ICDB/92682428; Sinkovics JG; Cancer Inst., St. Joseph's Hosp., Tampa, FL; Knowledge and expertise concerning artificially constructed hybridomas (the Kohler-Milstein technology and its modifications) rapidly increase. Information on naturally occurring hybridomas and on the role of these formations in the course and outcome of malignant disease remains in a most retarded state. The purpose
RETROVIRUS RECEPTORS EXPRESSED ON HUMAN CELLS (MEETING ABSTRACT): Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Diseases. October 6-11, 1991, Padova/Venice, Italy, p. 102, 1991.. Unique Identifier : AIDSLINE ICDB/92682440; Weiss RA; Chester Beatty Laboratories, Inst. of Cancer Res., London SW3; 6JB, UK; Eight distinct receptors have been delineated on human cells for 25 strains of C-type and D-type oncoviruses and lentiviruses. Some receptors are highly expressed in many cell lineages, whereas others are more restricted. The gene determining the receptor for the human and simian T-cell leukemia viruses resides on hum
HIV-1-INDUCED NEUROPATHY: HIV NEF EXHIBITS STRUCTURAL AND FUNCTIONAL SIMILARITIES TO PEPTIDES TARGETED TO ION CHANNELS (MEETING ABSTRACT): Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Diseases. October 6-11, 1991, Padova/Venice, Italy, p. 103, 1991.. Unique Identifier : AIDSLINE ICDB/92682441; Werner T; Ferroni S; Saermark T; Brack-Werner R; Banati RB; Mager R; Steinaa L; Keutzberg G; Erfle V; GSF-Center for Environmental and Health Res., Munchen, Germany; The molecular pathways leading to the HIV-mediated neuropathies are not well understood. Possibilities such as the neuronal killing of gp120 (Brenneman et al, 1990), the secretion of neurotoxic substances by HIV-1-infected macrophages (Giulian et al, 1990) or the neurotoxic activity of HIV-1 tat (Sabatia et al, 1991)
MOLECULAR STUDIES ON HTLV-1 GENE EXPRESSION ASSOCIATED WITH ADULT T-CELL LEUKEMIA AND TSP/HAM (MEETING ABSTRACT): Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Diseases. October 6-11, 1991, Padova/Venice, Italy, p. 106, 1991.. Unique Identifier : AIDSLINE ICDB/92682443; Yoshida M; Fujisawa J; Dept. of Cellular and Molecular Biology, Inst. of Medical Sci.,; Univ. of Tokyo, Shirokanedai, Minato-ku, Tokyo 108, Japan; Human T-cell leukemia virus type 1 (HTLV-1) is an etiologic agent of adult T-cell leukemia (ATL), and is also associated with tropical spastic paraparesia. Viral replication and gene expression are regulated by at least two viral transacting regulators, tax and rex, whose functions are also involved in development of
ANALYSIS OF CADMIUM-INDUCED MUTATIONS ALTERING CONDITIONALLY DEFECTIVE CELL TRANSFORMATION BY MUSVTS110 (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 33:A686 1992. Unique Identifier : AIDSLINE ICDB/92683212; Heckman CA; Murphy EC Jr; UT M.D. Anderson Cancer Center, Houston, TX 77030; A number of metals, including cadmium and nickel, are established carcinogens, but the mechanism by which they damage DNA is not well understood. For example, both are strongly clastogenic, but have proved negative or weakly mutagenic in prokaryotic assays. To study damage by carcinogens to mammalian genes, we develop
INHIBITION OF TUMOR PROMOTER-MEDIATED OXIDATIVE PROCESSES BY CAFFEIC ACID PHENETHYL ESTER (CAPE) (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 33:A967 1992. Unique Identifier : AIDSLINE ICDB/92683493; Frenkel K; Wei H; Bhimani R; Ye J; Huang MT; Ferraro T; Conney AH; Grunberger D; Dept. of Environmental Medicine, New York Univ. Medical Center,; New York, NY 10016; CAPE, a product isolated from the propolis of honey-bee hives, is cytotoxic to tumor and virally transformed, but not to normal cells. However, its mode of action is unknown. Since tumor promoters induce oxidative processes in vitro and in vivo, we evaluated the effect of CAPE upon these processes. We found that CAPE
POTENTIATION OF CYTOTOXICITY OF KAPOSI'S SARCOMA RELATED TO IMMUNODEFICIENCY SYNDROME (AIDS) BY LIPOSOME ENCAPSULATED DOXORUBICIN (LED) (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 33:A1483 1992. Unique Identifier : AIDSLINE ICDB/92684004; Masood R; Rahman A; Husain SR; Salahuddin SZ; Gill P; Dept. of Medicine, Norris Cancer Center, Univ. of Southern; California, Los Angeles, CA; Kaposi s sarcoma is an independent criteria for the diagnosis of AIDS and develops in nearly 30% of all cases. Current chemotherapy regimens are associated with substantial toxicity, particularly bone marrow suppression, which, thus, limits their use in many patients. To develop new modalities of treatment, LED was pr
HUMAN HERPES VIRUS-6 (HHV-6) INCREASES EXPRESSION OF HUMAN PAPILLOMA VIRUS (HPV) GENES IN MALIGNANT AND NONMALIGNANT CERVICAL CELLS (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 33:A2341 1992. Unique Identifier : AIDSLINE ICDB/92684897; DiPaolo JA; Chen MC; Corbellino M; Ablashi DV; NCI, Bethesda, MD 20892; Evidence associates HPVs as 1 factor in cervical cancer. This study examined the relationship between expression of HPV-16 or HPV-18 genes and HHV-6. HHV-6 transactivates HIV-1 LTR (HIV-1 has been found in cervicitis) suggesting that HHV-6 infection may affect other viruses such as cervical HPVs. Cervical HPV immortal
ACTIVATION OF PHORBOL DIESTER-INDUCED HUMAN IMMUNODEFICIENCY VIRUS GENE EXPRESSION IS INHIBITED BY ET-18-OCH3 AND RELATED ETHER LIPID ANALOGS (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 33:A2487 1992. Unique Identifier : AIDSLINE ICDB/92685008; Daniel LW; Civoli F; Smitherman PK; Wake Forest Univ., Winston-Salem, NC 27157-1016; The phorbol diester tumor promoter (TPA) stimulates protein kinase C (PKC), mimics the effects of growth factors on cell proliferation and stimulates replication of latent human immunodeficiency virus (HIV). Activation of the transcription factor NF-kB is associated with these effects. ET-18-OCH3 (1-O-octadecyl-2-O-me
NUCLEOSIDE TRANSPORT AND METABOLISM IN HUMAN IMMUNE CELLS (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 33:A2355 1992. Unique Identifier : AIDSLINE ICDB/92685077; Chan TC; Shaffer L; Redmond R; Pennington KL; Dept. of Physiology and Pharmacology, Purdue Univ., W. Lafayette,; IN 47907; There is a broad-specificity nucleoside transporter on mammalian cell membranes which is responsible for the facilitated uptake of endogenous nucleosides. It is unclear whether this nucleoside transport system is present in human immune cells, and whether any of the anti-HIV dideoxynucleosides are substrates of this f
2,3-DIDEOXYRIBOSE-1-PHOSPHATE, A MAJOR METABOLITE OF THE ANTI-HIV DIDEOXYPURINE DDINO (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 33:A2376 1992. Unique Identifier : AIDSLINE ICDB/92685086; Hao Z; Ford H; Ahluwalia G; Yeh H; Barchi J; Johns DG; Cooney DA; Lab. of Medicinal Chemistry, NCI, Bethesda, MD 20892; Purine nucleoside phosphorylase (PNP) cleaves dideoxyinosine to dideoxyribose-1-phosphate (ddR1P) and hypoxanthine. Previous attempts to identify ddR1P chromatographically have failed; we now trace that failure to the notable acid and heat lability of this sugar: its t1/2 at pHs 5, 7 and 10 being 1 min, 120 min and gr
PHARMACOKINETICS OF AN 'ANTISENSE' PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDE AFTER SUBCUTANEOUS INFUSION IN MICE (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 33:A3178 1992. Unique Identifier : AIDSLINE ICDB/92685713; Bigelow JC; Chrin LR; Mathews LA; McCormack JJ; Dept. of Pharmacology, Univ. of Vermont, Burlington, VT 05405; NSC 624958 is a phosphorothioate oligodeoxynucleotide (S-ODN; 27-mer) with a base-sequence antisense to the rev region of the HIV genome. Results of earlier pharmacokinetic studies, after iv administration to mice, suggested that continuous sc infusion might be an efficient approach to delivery of this drug. The maj
ANALYTICAL AND PHARMACOKINETIC STUDIES WITH AN ANTIVIRAL SULFONE DERIVATIVE (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 33:A3179 1992. Unique Identifier : AIDSLINE ICDB/92685714; Bigelow JC; Chrin LR; Mathews LA; McCormack JJ; Dept. of Pharmacology, Univ. of Vermont, Burlington, VT 05405; NSC 624231 is a phenyl sulfone derivative (PS) that has demonstrated activity against HIV in vitro. Detection and determination of PS in biological fluids is accomplished by HPLC analysis, using an ODS column and isocratic elution with acetonitrile/water (50/50); biological fluids are processed with acetonitrile prior
LYMPHOMA INDUCTION BY HUMAN B CELLS IN SCID MICE (MEETING ABSTRACT): Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Diseases. October 6-11, 1991, Padova/Venice, Italy, p. 2, 1991.. Unique Identifier : AIDSLINE ICDB/92682361; Amadori A; Veronese ML; Mazza MR; Zamarchi R; D'Andrea E; Menin C; Del Mistro A; Leszl A; Panozzo M; Chieco-Bianchi L; Inst. of Oncology, Univ. of Padova, Padova, Italy; The severe combined immunodeficiency (SCID) mouse represents a new interesting model for both immunologic and oncologic investigations. Several workers observed the high frequency with which SCID mice, injected ip with peripheral blood mononuclear cells (PBMC) from Epstein-Barr virus (EBV)-positive (+) donors, develop
TREATMENT OF NON-HODGKIN'S LYMPHOMAS (NHL) AND HUMAN IMMUNODEFICIENCY VIRUS (HIV) (MEETING ABSTRACT): Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Diseases. October 6-11, 1991, Padova/Venice, Italy, p. 30, 1991.. Unique Identifier : AIDSLINE ICDB/92682386; Gisselbrecht C; Tirelli U; Oksenhendler E; Gabarre J; Gastaldi R; Farcet JP; Lepage E; Raphael M; Monfardini S; GELA-GICAT, Inserm-CNR study, Hopital Saint-Louis, Paris 75010,; France; NHL HIV patients (pts) have a poor prognosis related to lymphoma and HIV infection. To evaluate whether a subset of pts could be treated with intensive chemotherapy, a pilot study was initiated based on a clinical stratification. Pts were stratified in 2 risk groups: group A, no opportunistic infection (OI) and perfor
CHARACTERIZATION OF EBV-POSITIVE LYMPHOBLASTOID B CELL LINES ORIGINATED FROM HIV-SEROPOSITIVE PATIENTS WITH AND WITHOUT LYMPHOMAS (MEETING ABSTRACT): Fifteenth Symposium of the International Association for Comparative Research on Leukemia and Related Disease. October 6-11, 1991, Padova/Venice, Italy, p. 78, 1991.. Unique Identifier : AIDSLINE ICDB/92682419; Roncella S; Francia Di Celle P; Cutrona G; Foa R; Carbone A; Rowe M; Ferrarini M; Istituto Nazionale per la Ricerca sul Cancro, Laboratorio di; Immunologia Clinica, Genova, Italy; EBV-positive B-cell lines (LCLs) were originated spontaneously,in vitro, from HIV-seropositive patients (pts). Particular caution was taken to ensure that the LCLs were originated by an in vitro expansion of in vivo latently infected B cells rather than by B cells infected by the EBV released in vitro. The LCLs from H
EFFECT OF RETROVIRAL LONG TERMINAL REPEAT (LTR)-CONTAINING TRANSGENES ON THYMIC LYMPHOMA INDUCTION IN FVB/N MICE NEONATALLY TREATED WITH AZACYTIDINE (MEETING ABSTRACT): Proc Annu Meet Am Assoc Cancer Res; 33:A1100 1992. Unique Identifier : AIDSLINE ICDB/92683623; Wang TH; Yang WK; Saavedra HI; Yang DM; Popp DM; Hoyt PR; Ch'ang LY; Yang MY; Biology Div., Oak Ridge Natl. Lab., Oak Ridge, TN 37831; In an attempt to activate the ecotropic LTR-containing transgene in FVB/N mice, we have found that neonatal injections of azacytidine can cause high incidence of thymic lymphomas in the transgenic mice at 3 to 7 mo of age, with massive involvement of thymus and other lymphoid tissues, as well as, tumor-cell infiltrati
Detection of Rhodococcus equi in tissues of HIV-infected patients by in situ hybridization (ISH) using a biotinylated probe.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:82 (abstract no. D-26). Unique Identifier : AIDSLINE ASM91/0010292; Brown J; McNeil M; Greer P; Lasker B; Bluth R; Schaffner W; Jahre J; Oblack D; Centers for Disease Control, Atlanta, GA.U Zaki S; R. equi, an emerging pathogen in severely immunocompromised patients, has recently been reported to cause disseminated fatal infections in HIV-infected patients. However, the diagnosis may be very difficult; definitive microbiologic identificatio may take 2 weeks and no fluorescein-labeled antibody test exists for R.
Detection and isolation of Mycoplasma fermentans from urine of patients with AIDS.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:134 (abstract no. G-4). Unique Identifier : AIDSLINE ASM91/0020292; Dawson MS; Wang R; Hayes M; Armstrong D; Budzko D; Lo SC; Kundsin R; ARP, Armed Forces Institute of Pathology, Washington, D.C.; Mycoplasmas of the M. fermentans species, a rarely identified urogenital mycoplasma was shown to infect the kidneys of HIV positive patients with AIDS-associated nephropathy. We set out in this study to 1) detect M. fermentans in the urine sediments of HIV positive patients utilizing the polymerase chain reaction (PCR
Selective detection of Mycoplasma fermentans using the polymerase chain reaction (PCR).: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:134 (abstract no. G-5). Unique Identifier : AIDSLINE ASM91/0030292; Wang R; Hu W; Dawson MS; Lo SC; Shih JW; ARP, Armed Forces Institute of Pathology, Washington, DC.; We previously developed a PCR assay for M. fermentans (incognitus strain). The assay using primer pairs RS47 and RS49 however failed to detect many mycoplasmas of the M. fermentans species, including PG-18, the prototype of M. fermentans and new clinical isolates from patients with AIDS. Recently, we reported the pres
Use of DNA probes to further characterize Mycobacterium avium complex (MAC) strains isolated from patients with AIDS.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:145 (abstract no. U-20). Unique Identifier : AIDSLINE ASM91/0040292; Yajko DM; Sanders CA; Kirihara JM; Nassos PS; Hadley WK; Gonzalez PC; Univ. of California, San Francisco Gen. Hosp. Med. Ctr., San; Francisco, CA.; Thirty stains of MAC isolated from AIDS patients (25 from blood, 4 from sputum, 1 from bile), that were previously characterized with regard to serotype and antimicrobial susceptibility patterns, were tested for reactivity with the 3 DNA probes in the SNAP (TM) (Syngene Inc, San Diego, CA) M. avium complex kit. The pr
Humoral response to Mycobacterium avium complex disease in AIDS and non-AIDS populations.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:148 (abstract no. U-33). Unique Identifier : AIDSLINE ASM91/0050292; Morris S; Armoa G; Rouse D; Chaparas S; Center for Biologics Evaluation and Research, FDA, Bethesda, MD; 20892.; Disease resulting from Mycobacterium avium, M. intracellulare complex (MAC) infections has become a serious complication for patients with acquired immmunodeficiency syndrome (AIDS). Because the detection of MAC disease is difficult and time-consuming, we have examined sera taken from AIDS and non-AIDS patients with M
Comparison of lymphocyte populations in patients infected with M. avium possessing varying colony morphology.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:148 (abstract no. U-34). Unique Identifier : AIDSLINE ASM91/0060292; Tassell SK; King B; Measel JW; Weis SE; Barrow WW; Biotherapeutics, Arlington, Texas.; The Mycobacterium avium complex is a group of opportunistic pathogens clinically important in AIDS patients and whose mechanisms of pathogenicity have not been defined. Lymphocyte populations were enumerated in a group of HIV-negative patients to identify modified immune parameters associated with chronic M. avium inf
Cost effective idenification of Mycobacteria isolated from blood.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:148 (abstract no. U-35). Unique Identifier : AIDSLINE ASM91/0070292; Kaminski DA; Weymouth LA; Casiano-Colon AE; Univ. of Rochester Med. Ctr., Rochester, NY.; Mycobacterium avium complex (MAC) is a common cause of disseminated infection and mycobacteremia in AIDS patients. A total of 994 blood specimens in Dupont Isolator tubes were received in our laboratory for mycobacterial culture during one year (8/89-7/90). 127 cultures (12.8%) from 26 patients were positive for mycob
Characterization of Mycobacterium avium isolated from multiple sites in AIDS patients.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:149 (abstract no. U-42). Unique Identifier : AIDSLINE ASM91/0080292; Yakrus M; Brown S; Smith C; Kilburn J; Good RC; Butler W; Centers for Disease Control, Atlanta, GA.; Mycobacterium avium can be isolated from a variety of sites in AIDS patients who have disseminated infection. We characterized isolates from multiple sites in 21 AIDS patients to determine if individual infections are due to one or more strains. Specimen sources included blood, sputum, stool, bronchial-alveolar lavage
In vitro synergistic inhibitory effect of ethambutol and vancomycin aginst Mycobacterium avium complex (MAC).: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:151 (abstract no. U-56). Unique Identifier : AIDSLINE ASM91/0090292; Berlin OG; Lang HL; Shum AC; UCLA Medical Center, Los Angeles, CA 90024-1713.; Fifty clinical isolates of MAC, from AIDS and non-AIDS patients (32 M. avium and 18 M. intracellulare), were tested against Ethambutol (EB) and Vancomycin (VA) individually and in combination. Commercially available antimicrobial disks (BBL Microbiology Systems, Cockeysville, MD) of EB (25 ug) and VA (30 ug) were plac
Therapeutic efficacy of Benzoxazinorifamycins against Mycobacterium avium complex infection induced in mice and rabbits.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:152 (abstract no. U-59). Unique Identifier : AIDSLINE ASM91/0100292; Saito H; Tomioka H; Sato K; Hidaka T; Shimane Medical University, Izumo, Japan.; Newly synthesized rifamycin derivatives, benzoxazinorifamycins (KRMs; Kanegafuchi Chemical Ind. Co., Osaka, Japan ), have a markedly improved in vitro activity against various mycobacteria including M.avium complex (MAC), and their MICs against most strains were more than 64 times lo
MICs and MBCs of clarithromycin for M. avium isolated from AIDS patients.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:152 (abstract no. U-60). Unique Identifier : AIDSLINE ASM91/0110292; Heifets L; Comstock D; Lindholm-Levy P; Natl. Jewish Ctr. Immunol. Respir. Med., Denver, CO.; Clarithromycin is the only antimicrobial agent that has been tested in a controlled clinical trial for the therapy of M. avium infection. This trial, conducted in France , has shown the ability of this drug to eliminate M. avium from the blood of AIDS patients. The aim of our study
Trends and correlations in Mycobacteria in an inner-city hospital 1983-89.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:153 (abstract no. U-65). Unique Identifier : AIDSLINE ASM91/0120292; Peters B; Olopoenia L; Frederick W; Delapenha R; Howard Univ. Hosp. and Col. of Med. Washington, DC.; Positive mycobacterial cultures (PMC) from 1983-89 were reviewed and compared. Total number of PMC, % of PMC due to M.tuberculosis (MTB), M.avium complex (MAC) and other mycobacteria (OM), mean age of patients (pts) and % of men with PMC were: TABULAR DATA, SEE ABSTRACT VOLUME. Yearly increases occurred in total PMC,
Sepsis caused by Mycobacterium tuberculosis (MTB) in Spanish patients.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:154 (abstract no. U-70). Unique Identifier : AIDSLINE ASM91/0130292; Mattar S; Drobnic L; Morta M; Hernaandez P; Saanzhez E; Urbina D; Gimeno O; Postgrado de Microbiologaia, Universidad de Cartagena and; Hospital Del Mar, Barcelona, Spain.; Mycobacteremia is rarely detected despite hematogenous spread of disease during dissemination, because culturing for MTB has not become a routine Laboratory test. In this work we studied 25 AIDS patients admitted to the Hospital with unknown fever. An HIV negative patient was also included in the study. Blood samples
Development of an escherichia coli culture and fermentation process for PL-regulated expression of HIV-1 protease.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:190 (abstract no. H-212). Unique Identifier : AIDSLINE ASM91/0140292; Strakalaitis N; Hoogerheide J; Mott J; Tomich CS; Brunner D; Vanzanten R; The Upjohn Co., Kalamazoo, MI.; HIV-1 protease consists of 99 amino acids and shares activity and homology with aspartyl proteases, such as pepsin and renin. Specific protease inhibitors block viral replication and infection, and are potential therapeutic agents for the treatment of AIDS. To date,
Virucidal efficacy of various lens cleaning and disinfecting solutions on HIV-I contaminted contact lenses.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:334 (abstract no. T-2). Unique Identifier : AIDSLINE ASM91/0150292; Amin RM; Dean MT; Poiesz BJ; Zaumetzer LE; VA Medical Center and SUNY Health Science Center at Syracuse, NY.; The isolation of Human Immunodeficiency Virus (HIV-I) from tears, cornea, conjuctival epithelium and contact lenses has raised significant concern about the possible transmissibility of this virus during routine opthalmologic procedures such as trial contact lens fittings. Because of this, we sought to determine viruc
A sensitive microculture assay for the isolation of human immunodeficiency virus type 1 (HIV-1) from blood leukocytes.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:334 (abstract no. T-3). Unique Identifier : AIDSLINE ASM91/0160292; Erice A; Sannerud KJ; Balfour Jr HH; Leske VL; Dept. of Lab Med. & Pathology. Univ. of Minnesota Hosp. and; Minnesota ACTU. Minneapolis, MN.; HIV-1 has been isolated by coculturing 10x10(6) peripheral blood mononuclear cells (PBMC) from HIV-1 seropositive patients (pospts) with 5x10(6) PHA-stimulated PBMC from normal donors. Because pospts contain high numbers of HIV-1 infected PBMC, we developed a microculture method (MCX) using fewer PBMC. 1x10(6) PBMC fr
Detection of HIV-1 transcropts and HIV-1 viremia by reverse-transcription polymerase chain reaction.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:334 (abstract no. T-4). Unique Identifier : AIDSLINE ASM91/0170292; Bagnarelli P; Clementi M; Menzo S; Pauri P; Valenza A; Varaldo PE; Manzin A; Institutes of Microbiology, University of Ancona and Trieste -; Italy.; Aim of the research has been to define a molecular boundary between virus latency and active replication phase in course of HIV-1 infection. For this purpose PBLs and plasma from seropositive subjects were checked for the presence of HIV-1 specific transcipts and genomic RNA (HIV-1 viremia), respectively, using revers
PCR detection of integrated HIV-1 DNA in peripheral blood lymphocytes (PBL) from infected individuals at various stages of disease.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:334 (abstract no. T-5). Unique Identifier : AIDSLINE ASM91/0180292; Casareale D; Kung K; Dragon B; Giron J; Wolfe L; PCR Division, Roche Diagnostic Systems Inc, Fair Lawn, NJ.; While available evidence indicates that viremia in HIV-infected individuals is not persistent and is influenced by neutralizing antibody levels, integrated HIV-1 DNA has been shown to be a more consistent marker for prior infection. Although most previous studies did not include terminal AIDS patients, in this study i
PCR sterilization: an evaluation of two methods.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:335 (abstract no. T-6). Unique Identifier : AIDSLINE ASM91/0190292; Frelow MM; Louie P; Rodgers G; Madej R; Roche Diagnostics Research, 1145 Atlantic Ave., Alameda, CA; 94501.; Contamination of polymerase chain reaction (PCR) reactions and DNA samples with previously amplified DNA products (amplicon) has become a source of concern. PCR sterilization involves the modification of elimination of amplicon contaminants. We have evaluated two methods for PCR sterilization: a post-PCR sterilization
Detection of HIV-1 and -2 infection by the polymerase chain reaction (PCR).: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:335 (abstract no. T-7). Unique Identifier : AIDSLINE ASM91/0200292; Brown V; Dela Torre N; Moore J; Fridlund C; George J; Schochetman g; Brattegaard K; Boateng E; Decock K; Ou CY; Centers for Disease Control. Atlanta, GA.; PCR is an effective diagnostic tool for the identification of HIV-1 infection from clinical specimens. Due to the presence of cross-seroreactivity and mixed infections in regions of West Africa, the use of PCR to differentiate HIV-1 and -2 infections is important. However, difficulty is encountered in designing HIV-2
Amplification of HIV gag and env genes from kidney biopsy archival material.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:335 (abstract no. T-8). Unique Identifier : AIDSLINE ASM91/0210292; Ferreira-Centeno A; Kimmel PL; Rodriguez ER; Farkas-Szallasi T; Abraham AA; Garrett CT; Departments of Pathology and Medicine, George Washington; University Medical Center, Washington D.C.; Patients infected with the HIV virus may develop a form of renal disease known as HIV-associated nephropathy. To elucidate whether HIV could cause renal disease directly, we first examined renal tissue from 8 patients with kidney disease to determine if HIV genome was present. DNA from paraffin sections of renal biops
PCR analysis of HIV protease sequences from lab isolates.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:335 (abstract no. T-9). Unique Identifier : AIDSLINE ASM91/0220292; Fontenot G; Cohen C; Robinson J; Johnston K; Luftig R; Dept. of Microbiology, Immunology and Parasitology; LSU Medical; Center, New Orleans, LA.; HIV replication involves a limited proteolysis of viral precursor proteins containing gag and gag-pol sequences by a specific viral protease. In order to characterize the HIV protease, sequences from: a) 5 patient isolates in New Orleans, b) 4 established strains grown in our lab, c) 10 strains in the Los Alamos datab
Primer extension analysis of the inhibition of purified HIV-1 reverse transcriptase by the TIBO analog, R82150.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:335 (abstract no. T-10). Unique Identifier : AIDSLINE ASM91/0230292; Noll GJ; Frank KB; Connell EV; Sim IS; Roche Res. Ctr., Nutley, NJ.; Recent studies have indicated that members of the TIBO (tetrahydro-imidazo [4,5,1-jk] [1,4]-benzodiazepin-2 (1H)-thione) family of compounds inhibit HIV-1 RT. We have used primer extension analysis to study the mechanism of action of one derivative. An in vitro transcript was made from a DNA construct containing the H
Development of an automated enzyme immunoassay for the detection and quantitation of human immunodeficiency virus (HIV) antigen.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:335 (abstract no. T-11). Unique Identifier : AIDSLINE ASM91/0240292; Bauer R; Cole C; Baxter Diagnostics, Mundelein, IL.; HIV is the etiologic agent of AIDS, and the demonstration of HIV antigen in patient serum or plasma samples correlates with disease progression. Further, monitoring HIV antigen levels during therapeutic intervention correlates with the therapeutic s efficacy. Thus, a method for the rapid and accurate quantitation of H
Comparison of whole cell viral lysate (VL), synthetic peptide (SP), and recombinant protein (RCP) EIA's for detection of HIV-1 antibody.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:336 (abstract no. T-12). Unique Identifier : AIDSLINE ASM91/0250292; Johnson JE; Univ. Kentucky and VA Medical Center, Lexington, KY.; Five hundred seventy five serum specimens received for HIV-1 antibody determination were tested prospectively by EIA using a whole cell viral lysate (Genetic Systems Corp.) a synthetic peptide ( United Biomedical , Inc.) and a recombinant protein (Syva Co.). Concordance of all 3
Human immunodeficiency virus type 1 (HIV-1) antibody testing: analytic sensitivity and analytic specificity of enzyme immunoassay (EIA) results.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:336 (abstract no. T-13). Unique Identifier : AIDSLINE ASM91/0260292; Cross GD; Schalla WO; Blumer SO; Hearn TL; Valdiserri RO; Centers for Disease Control, Atlanta, GA.; Laboratories enrolled in the CDC model performance evaluation program for HIV-1 antibody testing reported EIA results after testing HIV-1 performance evaluation samples sent them in February and May 1990. The panels contained 10 individual samples that were either HIV-1 antibody-negative, antibody-positive, or indeter
Evaluation of synthetic peptide EIA for HIV-1 and HIV-2 for use in seroprevalence studies.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:336 (abstract no. T-14). Unique Identifier : AIDSLINE ASM91/0270292; George R; Granade T; Holloman D; Schochetman G; De Cock K; Gayle H; Phillips S; Centers for Disease Control, Atlanta, GA.; Three commercial synthetic peptide EIAs (PEIA) for HIV-1 and -2 antibody and a combined HIV-1/2 EIA were evaluated for their sensitivity and specificity as compared to FDA-licensed whole virus lysate EIAs (VEIA) and Western blots (WB). A panel of 107 HIV-1 weakly reactive sera, 19 HIV-1 seroconversion panels, and 158
Opportunistic infections (OI) in patients with AIDS in central United States: differences from from large metropolitan areas.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:336 (abstract no. T-15). Unique Identifier : AIDSLINE ASM91/0280292; Woods GL; Goldsmith JC; University of Nebraska Medical Center (UNMC), Omaha, NE.; AIDS cases from the central United States in areas with less than or equal to 500,000 population are increasing; thus an awareness of the prevalence of infections in more rural locations is important to disease management and prevention. Of 102 adults (94 males, 8 females) with AIDS ca
Characterization of a murine monoclonal antibody to the transmembrane glycoprotein of human immunodeficiency virus type 2.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:336 (abstract no. T-16). Unique Identifier : AIDSLINE ASM91/0290292; Granade T; Parekh B; Phillips S; Pau C; George JR; Centers for Disease Control, Atlanta, GA.; Monoclonal antibodies (MAB) were developed to study the viral proteins of human immunodeficiency virus type 2 (HIV-2). Mabs were produced with standard techniques using whole viral lysate as immunogens. One MAB (1H5) displayed strong reactivity to the transmembrane glycoprotein gp41 by EIA and by Western blot analysis
Inhibition of HIV-2 induced syncytia formation by a monoclonal antibody.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:336 (abstract no. T-17). Unique Identifier : AIDSLINE ASM91/0300292; Rodriguez AE; Kraiselburd EN; Diaz AM; Dept. of Microbiology & Med. Zoology, Univ. of Puerto Rico, San; Juan, PR.; The purpose of this work was to test the ability of monoclonal antibodies to inhibit in vitro HIV-2 induced syncytia formation of CEMss cells. We have isolated one clone (K7.1) that produces monoclonal antibodies against HIV-2 antigens. These IgG antibodies were concentrated by injecting cloned cell into BALB/c mice,
HIV induction of lymphocyte-derived corticotropin.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:337 (abstract no. T-18). Unique Identifier : AIDSLINE ASM91/0310292; Hashemi FB; Hughes TK; Smith EM; Departments of Microbiology and Psychiatry, University of Texas; Medical Branch, Galveston, TX 77550.; AIDS is a disease which affects the immune, nervous and endocrine systems. Normally, cellular and humoral linkages exist among these three systems. We investigated HIV s role in altering these linkages via abnormal induction of ACTH by lymphocytes. Human peripheral blood mononuclear leukocytes (PBML) and cultured t-ly
Cytomegalovirus infection accelerates the rate of immunosuppression in HIV-infested subjects.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:337 (abstract no. T-19). Unique Identifier : AIDSLINE ASM91/0320292; Smith KO; Ludwig MJ; Ratner JJ; Boswell RN; The University of Texas Health Science Center at San Antonio and; the Wilford Hall USAF Hospital, San Antonio, TX.; This is the fourth year of a study to determine whether cytomegalovirus ( CMV ) might be a cofactor with the human immunodeficiency virus (HIV) to accelerate immunosuppression. Over seven hundred healthy HIV-seropositive U.S. A
Expression of CD4 and HIV-specific immunoglobulins in bacteria.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:337 (abstract no. T-20). Unique Identifier : AIDSLINE ASM91/0330292; McCallus DE; Ugen KE; Williams WV; Weiner DB; The Wistar Insitute and the University of Pennsylvania,; Philadelphia, PA.; The production of eucaryotic proteins in bacteria has been a major goal for many laboratories. We are attempting to express several HIV-related proteins in Escherichia coli using a pUC19-based vector. A bacterial plasmid (pDAB) was constucted containing the leader sequence for the pectate lyase protein of Erwinia caro
Detection of HTLVI DNA sequences by PCR in Multiple Sclerosis patients.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:338 (abstract no. T-27). Unique Identifier : AIDSLINE ASM91/0340292; Ferrante P; Mancuso R; Caputo D; Guerini F; Achilli G; Cattaneo E; Landini V; Zella D; Bertazzoni U; Don Gnocchi MS Ctr., Inst. Med. Microb. Univ. Milan, Italy.; In order to study the involvment of HTLVI in multiple sclerosis (MS) we searched HTLVI DNA in a group of 8 MS patients positive for antibody toward HTLVI antigens, in 18 MS patients without antibodies and in 8 healty controls. On the fresh PBL of all the subjects we performed PCR analysis using primers of the tax/rex
Assesment of human T-lymphotropic virus type I/II antibody testing.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:338 (abstract no. T-29). Unique Identifier : AIDSLINE ASM91/0350292; Blumer S; Schalla W; Cross D; Hearn T; Howerton D; Valdiserri R; Centers for Disease Control, Atlanta, GA.; In 3 performance evaluation surveys (September 1989, April and July, 1990), panels consisting of HTLV-I/II antibody-positive and antibody-negative plasma samples were mailed to more than 350 candidate reference and participant laboratories voluntarily enrolled in the CDC Model Performance Evaluation program for HTLV-I
Molecular characterization of recombinant BIV gag proteins.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:339 (abstract no. T-31). Unique Identifier : AIDSLINE ASM91/0360292; Atkinson RB; Liu ZQ; Wood C; University of Kansas, Lawrence, KS.; Bovine Immunodeficiencylike virus (BIV) is a member of the lentivirus subfamily of retroviruses. BIV has been shown to be antigenically related to HIV-1 from human, STLV-III from monkey, EIAV from horse, and CAEV from sheep. The purpose of our studies is to generate several recombinant BIV gag proteins for use in immu
Antigenic relatedness between HIV-1 and ovine progressive pneumonia virus.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:339 (abstract no. T-32). Unique Identifier : AIDSLINE ASM91/0370292; Maslak DM; Schmerr MJF; National Animal Disease Center, Agricultural Research Service,; USDA, Ames, IA.; Ovine progessive pneumonia virus (OPPV) is a lentivirus that infects sheep and causes a multi-systemic disease which can lead to death. The antigenic relatedness between HIV-1 and OPPV was examined by immunoblot analysis. Fourteen out of 20 sheep sera that were positive for OPPV on an immunodiffusion test reacted with
Specifice inhibition animal lentiviruses in cells by phosphorothioate oligodeoxynucleotides.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:339 (abstract no. T-33). Unique Identifier : AIDSLINE ASM91/0380292; Archambault D; Cohen J; Dahlberg J; Laval Univ., Ste-Foy, Quaebec, Canada.; One approach to prevent lentivirus infection, or at least limit virus spread within an infected host, is to make the use of anti-viral drugs. In this study, several phosphorothioate oligodeoxynucleotides were tested for their inhibitory effect on lentivirus replication in vitro. A 28-mer homooligomer of deoxycytidine
Retroviral sequences within the E-beta gene of the mouse MHC.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:339 (abstract no. T-35). Unique Identifier : AIDSLINE ASM91/0390292; Zimmerer EJ; Passmore HC; Murray State University, Murray, KY.; Sequence analysis in several inbred strains of mice through the second intron of the E-beta gene (MHC) revealed a major genetic rearrangement in the 5 half of this intron that separates the p and p-like haplotypes from the majority of common MHC haplotypes (b,d,k and s). A 597 bp nucleotide sequence found in the p ha
Higher frequency of HTLV-II over HTLV-I infection among Italian drug abusers.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:340 (abstract no. T-36). Unique Identifier : AIDSLINE ASM91/0400292; Ferrante P; Zella D; Mori L; Sala M; Casoli C; Magnani G; Lori F; Achilli G; Cattaneo E; Bertazzoni U; Ist. Med. Micr. Univ. Milano, Italy.; A cohort of 477 IVDAs was screened for the presence of HTLV-1 and HTLV-II with a particle agglutination assay, a WB procedure and by IFA. PBMC from 17 of 35 positive cases were further analysed by PCR amplification of tax sequences and detection with specific probes. Only one case out of 17 was confirmed positive for
Characterization of human herpes virus 6 gene segments that transactivate HIV promoter.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:341 (abstract no. T-45). Unique Identifier : AIDSLINE ASM91/0410292; Geng Y; Balachandran N; Wood C; University of Kansas, Lawrence, Kansas.; Human herpes virus 6 (HHV-6) is a recently isolated lymphotrophic herpes virus. HHV-6 can productively co-infect HIV-infected CD4+ T cells. It has been demonstrated that co-infection by both viruses can lead to accelerated cytopathic effects when compared to HIV or HHV-6 infection alone. We have demonstrated earlier t
Molecular cloning and characterization of a nuclear factor involved in the restricted HIV-1 expression in monocyte THP-1 cells.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:341 (abstract no. T-46). Unique Identifier : AIDSLINE ASM91/0420292; Mikovits J; Calvert I; West M; Young H; Ruscetti F; Kung H; Raziuddin; LBP, BRMP, BCDP, DCT, and PRI/DynCorp, National Cancer Institute,; FCRDC, Frederick, MD 21702-1201.; Monocyte/macrophage serves as a reservoir for HIV infection and plays a significant role in the pathogenesis of AIDS. We have established an HIV-1 infected human monocytic cell line THP-1 which showed multiple levels of viral expression; namely, 1) restricted or chronic low level expression and 2) high level expressio
L3T4+ subset of T-lymphocytes are responsible for paralysis and immunodeficiency induced by tsl, a mutant of moloney murine leukemia virus.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:341 (abstract no. T-47). Unique Identifier : AIDSLINE ASM91/0430292; Saha K; Wong PK; The University of Texas M. D. Anderson Cancer Center, Science; Park-Research Division, Smithville, TX 78957.; FVB mice develop hindlimb paralysis and immunodeficiency leading to death within 6 weeks when injected neonatally with a temperature-sensitive mutant (tsl) of MoMuLV. T-lymphocytes have been shown to be the primary target for tsl. In this study, we examined the role of L3T4+ (helper) T-cells in the disease pathogenesi
Quantitation of pneumocystis carinil cysts, trophozoites, and matrix in induced sputum using fluorescent monoclonal antibodies.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:349 (abstract no. C-41). Unique Identifier : AIDSLINE ASM91/0440292; Hulme P; Raviglione M; Currier J; Hanff P; Beth Israel Hospital, Harvard Medical School, Boston, MA.; Recent data suggest that the detection of Pneumocystis carinil (Pc) is more difficult in patients on aerosolized pentamidine (AP) prophyiaxis. To examine this issue, we quantitated the number of Pc cysts, trrophozoites, and matrix on positive slides made May 1989-November 1990 using a direct immunofluorescent monoclon
Evaluation of three stains for detection of Pneumocystis carinii.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:349 (abstract no. C-42). Unique Identifier : AIDSLINE ASM91/0450292; De Girolami PC; Dakos J; Karafotias G; Eichelberger K; New England Deaconess Hospital, Boston, MA.; We compared two direct immunofluorescent monoclonal antibody tests (DFA) from Genetic Systems (GS) and Meridian Diagnostics (MD) with a conventional Gram Weigert (GW) stain for rapid detection of Pneumocystis carinii (PC) in respiratory specimens. We tested 62 specimens including 26 bronchoalveolar lavage (BAL), 34 in
Diagnosis of disseminated human cytomegalovirus (HCMV) infection in patients with AIDS.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:353 (abstract no. C-66). Unique Identifier : AIDSLINE ASM91/0460292; Gerna G; Revello MG; Zipeto D; Parea M; Percivalle E; Univ. of Pavia and CNR Inst. of Genetics, Pavia, Italy.; Forty-seven AIDS patients were investigated for HCMV viremia when potentially HCMV-related symptoms were observed. Polymorphonuclear leukocytes (PMNL) from 153 blood samples were examined for: i) early virus isolation 24 h p.i. (viremia); ii) immediate-early antigen detection in PMNL (antigenemia); iii) HCMV DNA in bl
Evaluation of samples positive for cytomegalovirus (CMV) by polymerase chain reaction (PCR) for potenial confounding effect of HIV coinfection.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:353 (abstract no. C-67). Unique Identifier : AIDSLINE ASM91/0470292; Rockis M; Ferreira-Centeno J; Comerford J; Porter-Jordan K; Rodriguez R; Keiser J; Caparas MM; Ross A; Garrett C; George Washington University, Washington, DC.; PCR is considerably more sensitive than tissue culture (TC) for detection of CMV (Porter- Jordan et al., J Med Virol 30:85, 90) but the clinical significance of a positive resu
Evaluation of a rapid HIV-1 antigen monoclonal enzyme immunoassay.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:354 (abstract no. C-74). Unique Identifier : AIDSLINE ASM91/0480292; Rabito F; Pankey G; Mackenzie B; Cooper E; Leete J; Ochsner Clinic and Alton Ochsner Medical Foundation, New Orleans,; Louisiana.; Sera from 26 AIDS, 24 ARC, and 41 asymptomatic HIV-1 ELISA and Western Blot antibody-positive patients were tested, comparing a standard overnight HIV-1 antigen enzyme immunoassay (Abbott) with a rapid sandwich solid phase monoclonal enzyme immunoassay (Abbott) completed in 3.5 hours using an Abbott Dynamic Incubator.
Comparison of polymerase chain reaction (PCR) and virus culture for the detection of HIV-1 in pediatric patients.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:354 (abstract no. C-75). Unique Identifier : AIDSLINE ASM91/0490292; Hodinka RL; Titus DL; Dubin G; Friedman HM; Rutstein RM; Children's Hospital of Philadelphia and Univ. of Pennsylvania,; Philadelphia, PA.; PCR was compared with virus culture for the detection of HIV-1 from pediatric specimens. The study population included children infected with HIV, those born to HIV-seropositive mothers and children at low risk for HIV infection. A total of 67 specimens from 51 patients were examined. Peripheral blood mononuclear cell
Effect of the AIDS epidemic on the practice of clinical microbiology at a large acute care hospital.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:355 (abstract no. C-82). Unique Identifier : AIDSLINE ASM91/0500292; Southern PM; Byrd LA; Gander RM; The University of Texas Southwestern Medical Center and Parkland; Memorial Hospital, Dallas, Texas.; Parkland Memorial Hospital is a 900 bed county hospital that serves as a major teaching institution for our medical center. From 1980-90, bed size did not change appreciably, although major renovations occurred. Hospital admissions have increased by 130% since 1980, outpatient visits (ER and clinics) by 125%. An AIDS
In-Vitro susceptibility of dapsone against M. tuberculosis (MTB), and strains of M. avium (MA), and M. intracellulare (MI) isolated from AIDS patients.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:366 (abstract no. C-146). Unique Identifier : AIDSLINE ASM91/0510292; Kerkering TM; Espinel-Ingroff A; Dalton H; Warren N; Medical College of Virginia/VCU and State Consolidated; Laboratories, Richmond, VA.; The in-vitro susceptibility of dapsone against three genera of Mycobacteria was determined using a standardized disc elution agar test employing Mycobacteria 7H11 agar. MTB were from non-AIDS, and MA and MI were from AIDS pts. MA was differentiated from MI by DNA probe. 0.1ml. volumes of a 10(-3) and 10(-5) dilution o
Peritoneal dialysis related peritonitis in HIV positive vs. HIV negative patients.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:394 (abstract no. C-315). Unique Identifier : AIDSLINE ASM91/0520292; Marton R; Spinelli L; Slim J; Johnson E; Saint Michael's Medical Center, Newark, New Jersey.; The only therapeutic modalities available for HIV infected patients with end kidney disease (ESKD) are chronic ambulatory peritoneal dialysis (CAPD) or Hemodialysis (HD). A 6 year retrospective chart review was conducted in an inner city hospital of 91 patients undergoing CAPD to compare the incidence of peritonitis i
Treatment of human serum with a detergent/solvent combination for inactivation of human immunodeficiency virus (HIV) and hepatitis b virus (HBV) prior to determination of antibody levels to Neisseria meningitidis group A polysaccharide by ELISA.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:396 (abstract no. C-327). Unique Identifier : AIDSLINE ASM91/0530292; Bibb WF; Dewitt WE; Helsel LO; Carlone GM; Gheesling LL; Turner SH; Swaminathan B; Broome CV; CDC, Atlanta, GA. 30333.; The potential for occupational transmission of HIV and HBV may exist during manipulation of sera in the laboratory. A combination of 0.2% sodium cholate and 0.3% tri(n-butyl) phosphate has been shown to inactivate these viruses. Using a standardized ELISA, we studied the effects of these reagents on quantitation of an
Standardisation of an enzyme immunoassay for detection of IgG and IgM antibody against Hemophilus Ducreyi: time, HIV infection and performance.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:397 (abstract no. C-330). Unique Identifier : AIDSLINE ASM91/0540292; Desjardins M; Filion LG; Garber GE; Thompson CE; Cameron DW; Department of Microbiology and Immunology, University of Ottawa,; Ottawa, Ontario.; We standardised an enzyme immunoassay (EIA) for H. ducreyi IgG and IgM class antibodies to soluble antigen after serum absorption. A panel of 500 culture positive chancroid case and STD-negative control sera having substantial HIV prevalence was used for constructing receiver operator characteristic curves. We compare
Evaluation of the Cambridge Bioscience Recombigen HIV-1 EIA as a supplementary test for detection of antibodies to human immunodeficiency virus type 1.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:398 (abstract no. C-335). Unique Identifier : AIDSLINE ASM91/0550292; Starkey C; Yen-Lieberman B; Proffitt MR; The Cleveland Clinic Foundation, Cleveland, OH 44195.; We compared the performance of the Cambridge Bioscience (CB) Recombigen HIV-1 EIA, with a viral lysate-based screening assay, Genetic Systems (GS) LAV EIA, for the detection of antibodies to HIV-1. Of 473 sera tested, 169 were from kidney dialysis patients and 304 were from other sources, including STD and drug clini
Comparison of a recombinant antigen enzyme-immunoassay (EIA) with a viral lysate-based reference procedure for human immunodeficiency virus type 1 (HIV-1) serology.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:398 (abstract no. C-339). Unique Identifier : AIDSLINE ASM91/0560292; Wilcoski LM; Senf KL; Stevens JM; Janda WM; Univ. of Illinois Hosp., Chicago, IL.; Most laboratories performing HIV-1 serology use a viral lysated-based EIA and the Western blot supplemental test. Recombinant antigen-based EIAs have also been approved for screening serum specimens. In this study, the MicroTRAK HIV-1 recombinant antigen EIA (R-EIA, SYVA) was compared with a viral lysate-based EIA (L-
Hepatitis b delta HIV-1 HTLV-1 serologic profile in patients with malignancy in Gizan area of Saudi Arabia: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:400 (abstract no. C-347). Unique Identifier : AIDSLINE ASM91/0570292; Arya SC; Ashraf SJ; Pathak VP; Nanda V; King Fahad Centrai Hospital, Gizan, Saudi Arabia.; Serologic markers for HBV, HDV, HIV-1, HTLV-1 were tested in 42 patients with primary hepatocellular carcinoma (PHC). 19 with epithelial malignancy (EM) and 16 with non-epithelial malignancy (NEM). Total HBV exposure was 92% in 77 cases with a PHC, EM and NEM, with 75% HBsAg positives, 3.8% anti-HBc positive and 12.9%
Evaluation of the efficacy of subculture and extended incubation of BACTEC NR 660 blood culture media to detect fungemia.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:400 (abstract no. C-349). Unique Identifier : AIDSLINE ASM91/0580292; Robinson A; Binns L; Rhode Island Hospital and Brown University, Providence, RI.; The number of requests for fungal blood cultures has increased in our laboratory during the past 4 years. To assess the cost effectiveness of the more labor intensive fungal blood culture method, the respective values of 5 versus 28 days of incubation and blind subculture of BACTEC NR-660 culture media were assessed.
Unnamed gram negative rod isolated from AIDS patient description and changes on subculture.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:404 (abstract no. C-372). Unique Identifier : AIDSLINE ASM91/0590292; Clarridge JE; Simon BB; McGee H; VA Med. Ctr. and Baylor Col. of Med., Houston, TX.; The isolation of an unusual, unnamed GNR from HIV+ patients has been reported in the last year. We describe a similar, but not identical organism isolated from the blood of an AIDS patient on three occasions over a four month period. The cultures, positive only by lysiscentrifugation, produced small slow growing, rais
The seroprevalence of human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and human T-lymphotropic virus type I in a population of intravenous drug users in Albuquerque, New Mexico.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:404 (abstract no. C-376). Unique Identifier : AIDSLINE ASM91/0600292; Oty G; Levy A; Steece R; Voorhees R; Scientific Lab. Div., Albuquerque, NM.; From January of 1989 through September of 1990, 188 intravenous drug users admitted to a drug treatment clinic were tested for antibody to human immunodeficiency virus (anti-HIV) as part of a blinded nationwide seroprevalence study funded by the Centers for Disease Control. Additional tests to determine the serostatus
The incidence of HIV antibodies in persons with anti-treponemal antibodies in a New York City Hospital.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:405 (abstract no. C-377). Unique Identifier : AIDSLINE ASM91/0610292; Jones A; Lue YA; Grossman WS; Hewlett D Jr; Bolivar J; Lincoln Medical and New York Medical College, Bronx, New York,; NY.; There have been several reports which have associated the increase incidence of syphilis with illicit drug use. HIV infection has been associated with intravenous drug use. To determine the incidence of HIV antibody in individuals with specific treponemal antibodies, a random sampling of specimens positive and negativ
Prevalence of hepatitis B surface antigen, HIV-1 antibody and hepatitis C antibody among admissions to a Canadian hospital.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:405 (abstract no. C-378). Unique Identifier : AIDSLINE ASM91/0620292; Louie M; Low D; Feinman S; Chua R; Mitchell B; Baillargeon R; Simor A; Mount Sinai Hospital, Univ. of Toronto, Toronto, Canada.; The prevalence of hepatitis B surface antigen (HBsAG) and antibody to HIV (anti-HIV) and hepatitis C (anti-HCV) was determined in serial unselected adult admissions to a 450-bed tertiary care hospital. An anonymous unlinked serosurvey was done using sera collected from emergency and elective admissions for 6 months in
Clinical findings associated with isolation of Chlamydia sp. from BAL specimens.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:405 (abstract no. C-379). Unique Identifier : AIDSLINE ASM91/0630292; Hall C; Bugg F; Baselski V; University of Tennessee, Dept of Pathology, Memphis, TN.; With the recognition of Chlamydia pneumoniae as an important etiologic agent of pneumonia, in 1987 we instituted routine testing of bronchoalveolar lavage specimens (BAL) for Chlamydia sp. by McCoy cell culture and direct fluorescent antibody staining (DFA) using genus specific monoclonal reagents. A total of 8 cultur
Prevalence of neurosyphilis in HIV-infected patients with positive RPR.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:405 (abstract no. C-380). Unique Identifier : AIDSLINE ASM91/0640292; Holtom PD; Larsen RA; Leal ME; University of Southern California, Los Angeles, CA.; OBJECTIVE: To determine the prevalence of CSF VDRL-positive neurosyphilis in HIV-infected patients with positive serum RPR and MHA-TP. METHODS: HIV-infected patients initially seen at the LAC+USC Medical Center AIDS clinic from June to Dec 1990 with a positive serum RPR and no recent syphilis therapy were offered an L
Shigella bacteremia in AIDS patients.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:405 (abstract no. C-381). Unique Identifier : AIDSLINE ASM91/0650292; Kathpalia S; Hubbard-Shephard M; Dorigan F; Kocka FE; Cook County Hospital-Hektoen Institute, Chicago, IL 60612.; Shigella bacteremia in the general population is rare, however, it has been occasionally reported in AIDS patients. During the past 3 years we have encountered 3 cases of Shigella flexneri bacteremia in patients with AIDS. All 3 patients were homosexual, 2 were known to have gay bowel disease with S. flexneri prior to
Etiology of diarrhea among HIV-infected infants in Zaire.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:406 (abstract no. C-384). Unique Identifier : AIDSLINE ASM91/0660292; Wells J; Puhr N; Pavia A; Bopp C; Long E; Ryder R; Nsa W; Martin P; Griffin P; Centers for Disease Control, Atlanta, GA.; During March and April 1988, stool swabs were collected from 83 infants (ages 10-15 months) with diarrhea and 58 without diarrhea in Kinshasa, Zaire . Nine ill infants and 1 well infant were infected with HIV-1. Specimens were examined for Salmonella, Shigella, Campylobacter, Yersi
Treatment of non-meningeal cryptococcal disease in HIV-infected persons.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:409 (abstract no. F-4). Unique Identifier : AIDSLINE ASM91/0670292; Jones B; Larsen RA; Forthal D; Haghighat D; Bozzette S; California Collaborative Treatment Group USC, UCI and UCSD, CA.; OBJECTIVE: To evaluate the safety and efficacy of fluconazole and flucytosine in preventing evolution of cryptococcal meningitis in HIV positive persons with non-meningeal cryptococcosis. METHODS: Patients with non-meningeal cryptococcal infection were treated with fluconazole (400 mg/d) combined with flucytosine (150
Genetic variation among members of cryptococcus neoformans var. neoformans detected by cDNA and genomic probes.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:421 (abstract no. F-80). Unique Identifier : AIDSLINE ASM91/0680292; Spitzer ED; Spitzer SG; Dept. of Pathology, SUNY at Stony Brook, Stony Brook, NY.; C. neoformans is a leading cause of life-threatening infections in patients with AIDS. The ability to identify and analyze genetic differences among clinical isolates of C. neoformans would contribute to a better understanding of the virulence properties of this environmentally acquired pathogen. We have isolated seve
Evaluation of commercially available human immunodeficiency Virus-1 antibody immunoblotting kits.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:432 (abstract no. V-7). Unique Identifier : AIDSLINE ASM91/0690292; Warner NA; Leland DS; Suter LS; Indiana University Medical Center, Indianapolis, IN 46202.; Immunoblot (IB) kits for confirming the identity of human immunodeficiency virus-1 (HIV-1) antibodies are now available commercially. The purpose of this study was to compare IB kits from Bio-Rad, Ortho Diagnostics (formerly marketed by DuPont), American Bionetics (ABN), and Organon Teknika. A panel of 27 sera, 19 of
An enzyme immunoassay (EIA) to detect antibodies to human T-lymphotropic virus type-I in human plasma and serum.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:432 (abstract no. V-8). Unique Identifier : AIDSLINE ASM91/0700292; Anton-Byrnes J; Cole C; Smith L; Nath N; Nicol E; Baxter Diagnostics, Mundelein, IL.; Human T-Lymphotropic Virus Type-I (HTLV-I) has been associated with adult T-cell leukemia/lymphoma (ATL), tropical spastic paraparesis (TSP) and HTLV-I-associated myelopathy (HAM). An EIA has been developed for screening blood to prevent transmission of HTLV-I in cellular components during transfusion. The assay utili
An unique role of microbiologists in meeting the challenge of AIDS education.: Abstr Annu Meet Am Soc Microbiol. 1991 May 5-9;91:437 (abstract no. ED-13). Unique Identifier : AIDSLINE ASM91/0710292; Manuselis G; The Ohio State University, Columbus, OH.; With over 125,000 current cases, the aquired immunodeficiency syndrome (AIDS) continues to tax our traditional health care system. Due to increased numbers and increased longevity of AIDS patients, more health professionals will be exposed to and involved in the treatment of these individuals in the future. As the epi
Pathogenic (SIVmac-239) and nonpathogenic (SIVmac-1A11) molecular clones of SIV have distinct tissue distributions that vary with length of infection.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:21 (abstract no. 1). Unique Identifier : AIDSLINE PRIM9/0720292; Lackner AA; Vogel P; Hoogenboom E; Dandekar S; Kluge JD; Marthas M; New Mexico Regional Primate Research Laboratory, NMSU and; California Regional Primate Research Center, UC Davis.; To examine the pathogenesis of SIV we inoculated two groups of eight rhesus macaques with equal doses of either a pathogenic or nonpathogenic molecular clone of SIVmac (SIVmac-239 and SIVmac-1A11 respectively) and compared them to a third group of eight rhesus inoculated with an uncloned, biologic isolate of SIVmac (d
Development of a macrophage-topic, neurovirulent strain of SIV by multiple intracerebral passage.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:22 (abstract no. 2). Unique Identifier : AIDSLINE PRIM9/0730292; Zink MC; Sharma D; Adams RJ; Narayan O; Johns Hopkins University School of Medicine, Div. Comparative; Medicine, Baltimore MD 21205.; In man, HIV causes both non-suppurative encephalitis, and opportunistic infections secondary to immunosuppression. Whereas the immunosuppression is a result of the systemic depletion of infected CD4+ cells, studies using double staining on the brains of AIDS patients with dementia
Correlates of SIV-induced lesions in the central nervous system of experimentally infected rhesus monkeys.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:23 (abstract no. 3). Unique Identifier : AIDSLINE PRIM9/0740292; Baskin GB; Murphey-Corb M; Roberts ED; Didier PJ; Tulane Regional Primate Research Center, Tulane University,; Covington, Louisiana.; Necropsy records were reviewed from 204 SIV-infected rhesus monkeys that had been inoculated with various strains of SIV (166/204 with SIVDeltaB670) and had died of SIV-related disease. Of these, 66/204 (32%) had SIV-induced lesions in the brain parenchyma (range 0 - 62%/study); 24/204 (12%) had SIV-induced lesions in
Pathogenisis of the genital transmission of SIV: localization of SIV in the reproductive tract of chronically infected rhesus macaques.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:24 (abstract no. 4). Unique Identifier : AIDSLINE PRIM9/0750292; Miller CI; Vogel P; Hendrickx A; Alexander N; Dandekar S; Marx P; California Regional Primate Research Center, University of; California, Davis; An animal model for the heterosexual transmission of HIV was developed by infusing cell-free SIV into the vagina of female rhesus macaques or onto the foreskin glans and urethral os of male rhesus macaques. Animals inoculated by the genital route become persistently viremic and eventually develop simian AIDS. Thus the
Early pathogenesis of infection by SIVsmmPBj14 molecular clone 1.9 in macaques.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:25 (abstract no. 5). Unique Identifier : AIDSLINE PRIM9/0760292; Hoover EA; Israel ZR; Maul DH; Dean GA; O'Neil SP; Dreitz MJ; Mullins JI; Fultz PN; Department of Pathology, Colorado State University, Fort Collins,; CO 80523, USA.; We have studied the early pathogenesis of infection by molecular clone 1.9 of simian immunodeficiency virus (SIV) sooty mangabey (SMM) strain PBj14 in 4 pig-tailed (Macacca nemestrina) and 2 cynomolgus macaques (Macacca fasicularis) infected intravenously with either 6.3 x 10(4) (2 animals) or 6.3 x 10(3) TCID50 (4 an
Molecular cloning of SIVsmm/PBJ and identification of pathogenic determinants.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:26 (abstract no. 6). Unique Identifier : AIDSLINE PRIM9/0770292; Novembre FI; Hirsch VM; McClure HM; Johnson PR; Department of Microbiology, Georgetown University, and Laboratory; of Infectious Diseases, NIAID/NIH, Rockville, MD.; SIVsmm/PBj (PBj) induces a rapidly fatal disease (acute death syndrome) when inoculated into macaques. This syndrome, in contrast to the protracted immunodeficiency ordinarily associated with SIV, is characterized by a fulminant diarrhea and acidosis leading to death in 5 to 14 days. Genetic analysis of molecularly cl
Genetic mapping of viral determinants of SIV pathogenesis.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:27 (abstract no. 7). Unique Identifier : AIDSLINE PRIM9/0780292; Marthas M; Lohman B; Van Rompay K; Banapour B; Ramos R; Unger R; Higgins J; Torten J; Luciw P; Pedersen N; California Regional Primate Research Center, University of; California, Davis, CA 95616.; To identify viral determinants of pathogenesis, we constructed pairs of reciprocal recombinants between two molecular clones of SIVMac which are pathogenic (239) and a non-pathogenic (1A11). A large (6.2 kb) fragment containing gag, pol and env as well as regulatory genes (vpr, vif, and the first exons of tat and rev)
In vivo macrophage tropism of pathogenic and non-pathogenic molecular clones and recombinants of simian immunodeficiency virus (SIVmac).: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:28 (abstract no. 8). Unique Identifier : AIDSLINE PRIM9/0790292; Unger RE; Marthas ML; Lackner AA; Pratt-Lowe E; Lohman BL; Ronpay KV; Luciw PA; Department of Medical Pathology and the California Regional; Primate Research Center, University of California, Davis, 95616.; In vitro macrophage tropism differs between different molecular clones of SIVmac and recombinants between these clones. SIVmac1A11 is highly macrophage tropic for rhesus monocyte-derived and alveolar macrophages and SIVmac239 does not infect macrophages under these in vitro conditions (Banapour et al. Virology 183:12-
Modulation of SIV replication in macrophage cultures by neutralizing antibodies from SIV infected macaques.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:29 (abstract no. 9). Unique Identifier : AIDSLINE PRIM9/0800292; McEntee M; Anderson M; Zink MC; Clements J; Narayan O; Johns Hopkins University School of Medicine, Baltimore, MD.; The lentiviruses HIV and SIV cause productive infections in CD4+ lymphocytes and macrophages. The life-cycle of the virus is approximately 24 hours but inoculated cells require several days to reach their full productive potential. In vivo, infected cells rarely reach this potential during the subclinical phase of inf
Arteriopathy in macaques infected with simian immunodeficiency virus (SIVmac).: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:30 (abstract no. 10). Unique Identifier : AIDSLINE PRIM9/0810292; Chalifoux LV; Wyand MS; Desrosiers RC; Ringler DJ; Harvard Medical School, New England Regional Primate Research; Center, 1 Pine Hill Dr., Southborough, MA, USA.; Arteriopathy has been associated with human pediatric AIDS cases. A similar arteriosclerosis was seen in 19 of 85 Macaca mulatta infected with SIVmac. Fourteen were experimentally inoculated with uncloned SIVmac251, two were inoculated with tissue or blood from other SIVmac251-infected monkeys, two were naturally infe
Receptor-mediated activation of SIVagm by sCD4.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:31 (abstract no. 11). Unique Identifier : AIDSLINE PRIM9/0820292; Allan JS; Whitehead E; Hart T; Buck D; Bugelski P; Southwest Foundation for Biomedical Research, San Antonio, Texas.; The process of viral entry requires a complex series of conformational changes known as activation steps for the induction of viral fusion. As an example, influenza viruses undergo pH induced conformational changes which are thought to facilitate fusion. We previously theorized that the viral receptor for immunodefici
Gamma/delta T cells and SIV infection.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:32 (abstract no. 12). Unique Identifier : AIDSLINE PRIM9/0830292; Malkovsky M; MacKenzie D; Radtke B; Manning J; Fisch P; WRPRC, University of Wisconsin, Madison, Wisconsin.; The TCR delta 1 monoclonal antibody which reacts with all human gamma delta T cells also shows strong binding to a subset of CD3+ rhesus monkey peripheral blood mononuclear cells (4.9+/-3.0%), lymph node (4.4+/-1.6%) and speen (9.0+/-2.5%) cells (the values in parentheses represent means+/-SDs). The monkey TCR delta 1
Preferential replication of a clinical HIV-1 isolate in chimpanzee peripheral blood mononuclear cells.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:33 (abstract no. 13). Unique Identifier : AIDSLINE PRIM9/0840292; Fultz PN; Keddie E; Ghosh S; Shaw G; University of Alabama at Birmingham, Birmingham, AL 35294.; Previously, a chimpanzee-passaged strain of HIV-1, termed LAV-1b, was shown to replicate in chimpanzee PBMC and macrophages more efficiently than all other isolates of HIV-1 tested. LAV-1b also was shown to be cytopathic for both chimpanzee and human CD4+ lymphocytes, but the virus replicated equally well or better in
Simian virus-40 (SV40)-induced disease in macaques with AIDS.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:34 (abstract no. 14). Unique Identifier : AIDSLINE PRIM9/0850292; Horvath CJ; Simon MA; Bergsagel DJ; Garcea RL; Ringler DJ; Harvard Medical School, NERPRC, Southborough, MA, 01772-9102.; Recrudescence of latent DNA virus infections (e.g. herpes simplex, varicella-zoster) is a prominent feature of human AIDS. The Polyomavirinae subfamily of Papovaviridae includes DNA viruses which remain latent in renal tissue of humans (JCV and BKV) and rhesus monkeys (SV40). Polyomaviral disease in the natural host i
The role of genetic change in tissue tropism of SIVmac during the development of AIDS.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:35 (abstract no. 15). Unique Identifier : AIDSLINE PRIM9/0860292; Kodama T; Mori K; Ringler DJ; Desrosiers RC; New England Regional Primate Research Center, Harvard Medical; School, Southborough, MA USA.; Molecularly cloned SIVmac239 induces AIDS and death in the common rhesus monkey. As with HIV-induced disease in humans, the disease induced by SIVmac239 is heterogenous in nature. Rhesus monkey 316-85 died 5 1/2 months following infection with cloned SIVmac239 with generalized lymphoid depletion, giant cell pneumonia
Cell-specific variation of SIV/MNE in vitro and in vivo.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:36 (abstract no. 16). Unique Identifier : AIDSLINE PRIM9/0870292; Rudensey L; Wilson J; Papenhausen M; Overbaugh J; Department of Microbiology and Regional Primate Research Center,; University of Washington, Seattle, WA.; We have previosly reported the identification of two highly variable domains in the SIV/Mne env gene that correspond to V1 and V4 in HIV env. Other regions known to be variable in HIV, such as the V3 loop, were well conserved following SIV infection in vivo. In V1, change was detectable before CD4 depletion, but becam
Synthetic peptides designed to inhibit the HIV protease inhibit the protease of mason pfizer monkey virus preventing maturation and cleavage of gp22(TM) to gp20.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:37 (abstract no. 18). Unique Identifier : AIDSLINE PRIM9/0880292; Sommerfelt MA; Hunter E; University of Alabama at Birmingham, Dept. of Microbiology,; Birmingham, AL. 35294.; The MPMV protease is defined as an aspartyl protease and is responsible for cleavage of structural gene precursor proteins either during or shortly after budding in the process of maturation. The MPMV transmembrane (TM) envelope glycoprotein is initially cleaved from the Pr86 envelope precursor by a Golgi endopeptidas
Sequence analysis of SIVmac251 (32H reisolate) direct from macaques following infection.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:38 (abstract no. 17). Unique Identifier : AIDSLINE PRIM9/0890292; Almond N; Slade A; Jenkins A; Jones S; Chan WL; Flanagan B; Gaisford W; Ling C; Rose J; Page M; et al; NIBSC, Potters Bar, UK.; An important step in our understanding of virus-host interactions is the characterisation of virus sequences which are important in vivo and how these sequences may change during the course of infection and disease. Two cynomolgus macaques were infected with 10 MID50 of the 11/88 pool of the 32H reisolate of SIVmac251
The LTRs of two strains of SIVmac are differentially transactivated.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:39 (abstract no. 19). Unique Identifier : AIDSLINE PRIM9/0900292; Anderson M; Clements JE; The Johns Hopkins University School of Medicine Baltimore,; Maryland 21205 USA.; Two infectious molecular clones of the simian immunodeficiency virus - SIVmac251 and SIVmac239 have been found to have very different biologic effects in vivo as well as different transcriptional activities in cell culture. While SIVmac239 can cause AIDS-like symptons and death in 6 months or less, SIVmac251 causes a
Propagation of SIV vectors by genetic complementation.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:40 (abstract no. 20). Unique Identifier : AIDSLINE PRIM9/0910292; Rizvi TA; Panganiban A; McArdle Laboratory for Cancer Research, University of Wisconsin,; Madison, WI 53706.; In order to study SIV replication over a single round of replication we generated SIV239 virus particles that contain a replication defective vector containing a selectable marker. Genetic complementation between an env deficient SIV variant and plasmid that expresses the env gene of an amphotropic murine retrovirus r
SIV from Sykes' monkeys: prototype for a fifth group of primate lentivruses.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:41 (abstract no. 21). Unique Identifier : AIDSLINE PRIM9/0920292; Hirsch VM; Dapolito G; McClure H; Isahakaia M; Fultz PN; Johnson PR; Dept. of Microbiology, Georgetown University and Laboratory of; Infectious Diseases, NIAID, NIH, Rockville, Md.; Four distinct groups of primate lentiviruses have been identified to date: (i) HIV-1, including SIVcpz from a chimpanzee; (ii) HIV-2, a including SIV from sooty mangabeys (SIVsm), and SIV from macaques (SIVmac); (iii) SIV from African green monkeys (SIVagm); and, (iv) SIV from mandrills (SIVmnd). Sykes monkeys (Cerco
Maternal-fetal transmission of SIV in macaques.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:42 (abstract no. 22). Unique Identifier : AIDSLINE PRIM9/0930292; Ochs HD; Morton WR; Zhu Q; Kuller LD; Thouless ME; Benveniste RE; Department of Pediatrics, University of Washington, Seattle, WA.; To study the mechanisms of maternal-fetal transmission of HIV and to test strategies to prevent infection of the fetus, we have developed a model of maternal-fetal transmission in macaca (M.) nemestrina using the primate lymphotropic immunodeficiency virus, SIV/Mne. To date we have inoculated intravenously twelve M. n
Vaccination of pregnant cynomolgus monkeys with whole inactivated SIVmac.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:43 (abstract no. 23). Unique Identifier : AIDSLINE PRIM9/0940292; Titti F; Borsetti A; Geraci A; Sernicola L; Giuseppini L; Turillazzi GP; Pace M; Baroncelli S; Chieco-Bianchi L; Verani P; et al; Lab. Virology, Istituto Superiore di Sanitga Rome; The aim of the work was to study the antibody response in monkeys immunized during pregnancy, the effect, if any, of immunization on foetal growth, and passive transfer of antibodies to offsprings. Five pregnant (2-3.5 months) Macaca fascicularis were immunized with sucrose-gradient purified and formalin inactivated w
Decline in the CD4% and CD4/CD8 ratios in blood of SIV infected monkeys is not accompanied by concomitant decrease within the CD4+ pool present in lymph nodes.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:44 (abstract no. 24). Unique Identifier : AIDSLINE PRIM9/0950292; Rosenberg YJ; White BD; Papermaster SF; Zack PM; Jahrling PB; Eddy GA; Burke DS; Lewis MG; Henry M. Jackson Foundation Research Laboratory, Rockville, MD.; Although circulating CD4%, CD4+ cell counts and CD4/CD8 ratios are valuable in evaluating clinical progression to AIDS, it is not known how these values reflect the CD4+ cell pool as a whole. To examine this directly, lymphocytes from LN, spleen and PBMC from 16 SIV-PBj-14 infected macaques have been analyzed phenotyp
CD34+ progenitor cell, colony forming unit-granulocyte/macrophage (CFU-GM) and burst forming unit-erythroid (BFU-E) analysis in SIVsmm infected rhesus macaques (RM); functional bone marrow abnormalities without evidence of direct stem cell infection.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:45 (abstract no. 25). Unique Identifier : AIDSLINE PRIM9/0960292; Hillyer CD; Lackey DA; Villinger F; Winton EF; Ansari AA; McClure HM; Department of Pathology, Emory University, Atlanta, Georgia.; CFU-GM and BFU-E were cultured from iliac crest bone marrow aspirates of RM infected with SIVsmm9 (Macaca mulatta; n=15) and of SIV RM (n=8). Each culture plate contained 1x10(5) MNC/ml in 0.9% methylcellulose with 30% fetal calf serum, 5% rhesus PHA-LCM, 1 U/ml erythropoietin, 5x10(-5) M mercaptoethanol, penicillin a
Infection of Macaca nemestrina by human immunodeficiency virus (HIV-1).: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:46 (abstract no. 26). Unique Identifier : AIDSLINE PRIM9/0970292; Agy MB; Schmidt AM; Frumkin LR; Morton WR; Corey L; Katze MG; Regional Primate Research Center, University of Washington,; Seattle, WA 98195.; Objective: The current study was undertaken to determine the susceptibility of M. nemestrina to HIV-1 infection. Our preliminary in vitro and in vivo results are described here. Methods: (In vitro studies). Initially, peripheral blood mononuclear cells (PBMCs) were prepared from M. nemestrina, PHA stimulated and eithe
Altered course of primary syphilis in rhesus macaques with SIV infection.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:47 (abstract no. 27). Unique Identifier : AIDSLINE PRIM9/0980292; Marra CM; Handsfield HH; Kuller L; Morton WR; Lukehart SA; Department of Medicine and Regional Primate Research Center,; University of WA, Seattle, WA.; The natural history of early syphilis may be altered in HIV-infected persons, with more severe clinical manifestations and altered serological responses. Because the immunodeficiency caused by SIV and HIV are similar, we are studying the course of primary syphilis in 2 SIV-infected and 2 SIV-uninfected rhesus macaques
The anti-viral effect of AZT in rhesus monkeys infected with uncloned SIVmac251.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:48 (abstract no. 28). Unique Identifier : AIDSLINE PRIM9/0990292; Wyand MS; Partis RA; Mueller RA; Desrosiers RC; Tiemeier DC; TSI Mason Laboratories, Department of Experimental Medicine,; Worcester, MA.; The anti-viral effect of AZT was studied in a group of 10 male juvenile rhesus monkeys. Animals were randomized by weight into an untreated Group 1 (5 animals) and an AZT treated Group 2 (5 animals). AZT at 66.7 mg/kg was administered three times dail
Parenterally administered formalin-inactivated SIVmac protects rhesus macaques from intrarectal challenge.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:49 (abstract no. 29). Unique Identifier : AIDSLINE PRIM9/1000292; Cranage MP; Cook N; Dennis M; Rose J; Kitchin P; Baskerville A; Greenaway PJ; PHLS Centre for Applied Microbiology and Research, Porton Down,; Salisbury, SP4 OJG, UK.; Six rhesus macaques were inoculated intrarectally with the 11/88 vaccine challenge stock of SIVmac 32H isolate. Two animals were each inoculated with 3ml of virus at 10(-1), 10(-2) or 10(-3) respectively. Virus was recovered from both animals receiving 10(-1) and from one animal receiving 10(-2) virus dilutions from P
A formalin inactivated whole SIVmac vaccine formulated in RIBI adjuvant protects against homologous and heterologous SIV challenge.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:50 (abstract no. 30). Unique Identifier : AIDSLINE PRIM9/1010292; Putkonen P; Thorstensson R; Cranage M; Greenaway P; Albert J; Biberfeld G; The Departments of Immunology and Virology, The National; Bacteriological Laboratory, S-105 21 Stockholm, Sweden.; Eight cynomolgus monkeys received four intra-muscular 500 microgram doses of formalin inactivated SIVmac formulated in RIBI adjuvant on days 0, 30, 63 and 125. Four control animals received RIBI adjuvant only. No adverse reactions to vaccination were seen. Four vaccinated animals, together with two controls, were chal
Inactivated whole virus vaccine derived from a proviral DNA clone of SIV confers protection against homologous and heterologous challenge.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:51 (abstract no. 31). Unique Identifier : AIDSLINE PRIM9/1020292; Johnson PR; Montefiori DC; Chou J; Goldstein S; Hamm TE; Kitov S; Haigwood NL; Misher L; London WT; Gerin JL; et al; Department of Microbiology, Georgetown University, Rockville, MD.; The SIV model system has been an extremely useful tool for studying the pathogenesis, treatment, and prevention of primate lentivirus infections. With regard to vaccine development, other investigators have demonstrated in the past two years that inactivated whole-virus vaccines can prevent infection from a low dose (
Whole-inactivated and live, virulence-attenuated SIV vaccines protect rhesus macaques against infection by intravenous but not vaginal routes of challenge.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:52 (abstract no. 32). Unique Identifier : AIDSLINE PRIM9/1030292; Marthas ML; Sutjipto S; Miller C; Higgins J; Torten J; Unger R; Marx PA; Pedersen NC; California Regional Primate Research Center, University of; California, Davis, CA 95616.; We evaluated the ability of whole-inactivated and live-attenuated SIV vaccines to elicit immune responses which protect against intravenous (IV) or vaginal challenge. Four male and six female rhesus macaques received multiple intramuscular (IM) inoculations with UV-psoralen inactivated, uncloned SIVmac-251 in adjuvant
Vaccine protection against SIV infection in macaques.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:53 (abstract no. 33). Unique Identifier : AIDSLINE PRIM9/1040292; Mills KHG; Stott EJ; Kitchin PA; Gaisford W; Taffs F; Corcorran T; Silvera P; Rose J; Ling C; Bruck C; NIBSC, Potters Bar, Herts, UK.; It has previously been reported by us and others that immunisation with inactivated virus preparations can confer protection against homologous or heterologous SIV challenge. In the present study we have extended these findings to show that protection against low dose (10MID50) SIVmac 32H challenge can be achieved by
Development of recombinant vaccines against aids in primate models.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:54 (abstract no. 34). Unique Identifier : AIDSLINE PRIM9/1050292; Hu SL; Abrams K; Barber GN; Moran P; Zarling JM; Kuller L; Morton WR; Benveniste RE; Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle,; WA.; Recombinant viruses have been used to develop vaccines against retroviruses that cause AIDS-like diseases in primates. We previously showed that immunization with a recombinant vaccinia virus expressing the envelope glycoproteins of simian type D retrovirus (SRV) protected macaques against the homologous strain of SRV
Prior vaccination of macaques with conserved SIV envelope peptides does not stop initial infection but prevents transmission, disease progression and viral persistence.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:55 (abstract no. 35). Unique Identifier : AIDSLINE PRIM9/1060292; Eddy GA; Shafferman A; Lewis MG; Benveniste R; Lai CY; Jahrling PB; Eden-McCutchan F; Burke DS; Henry M. Jackson Foundation, Rockville, MD.; Earlier reports described rhesus macaques which had been immunized with a mixture of four peptides, from conserved, hydrophilic SIV envelope regions and challenged with 100 cell culture infectious doses of a biological clone of SIV/Mne. In this study they were tested for residual infectious virus and additional immune
Characterization of group specific antibodies in primates: studies with recombinant envelope antigens of HIV-1 in chimpanzees and baboons and of SIV in rhesus macaques.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:56 (abstract no. 36). Unique Identifier : AIDSLINE PRIM9/1070292; Haigwood NL; Misher LE; Planelles V; Gardner MB; Johnson PR; Steimer KS; Chiron Corporation, Emeryville CA.; Neutralizing antibodies have been shown to be protective against HIV-1 infection in chimpanzees. We have shown that high titer, cross-neutralizing activity against U.S., European, Carribean and African isolates was generated with native, glycosylated rgp120SF2 and low titer, more isolate-restricted neutralizing activi
Immune response of monkeys to a vaccination with vaccinia-HIV2Rod recombinants and purified proteins.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:57 (abstract no. 37). Unique Identifier : AIDSLINE PRIM9/1080292; Vogt G; LeGrand R; Kieny MP; Kaczorek M; Sonigo P; Girard M; Dormont D; SSA/DSV/DPTE/CEA, Fontenay aux Roses, France.; Objective: 1) To investigate the immune response of Rhesus monkeys vaccinated with a mixture of vaccinia-HIV2 recombinants, and boosted with purified proteins. 2) To determine the usefulness of anti-env response in the potential protection against HIV2. Methods: Our vaccine strategy involved different recombinant vacc
Human mesangial cells are resistant to productive infection by multiple strains of human immunodeficiency virus types 1 and 2.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:59 (abstract no. 38). Unique Identifier : AIDSLINE PRIM9/1090292; Alpers CE; McClure J; Hudkins KL; Bursten SL; University of Washington School of Medicine, Seattle, WA.; Human immunodeficienty virus-associated nephropathy (HIVAN) is a recognized clinical entity of unknown pathogenesis, which affects as many as 10% of patients infected with HIV in some medical centers. A role for viral infection of kidney cells in the initiation of this process at present is an intriguing but untested
Staphylococcal enterotoxins (superantigens) increase viral expression in SIV infected lymphocytes from macaca nemestrina.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:60 (abstract no. 39). Unique Identifier : AIDSLINE PRIM9/1100292; Axberg I; Firpo PP; Liang A; Clark EA; Regional Primate Research Center, University of Washington,; SJ-50, Seattle, WA 98195 USA.; Staphylococcal toxins, also called superantigens (SuperAg), are proteins secreted from Staphylococcus aureus (S. aureus) that can cause food poisoning in man and experimental animals. We have found that these SuperAg have a stimulatory effect on macaque peripheral blood lymphocytes (PBL) (J. Clin. Immunol., 11, in pre
Demonstration of SIV-specific structural viral proteins in infected AA-2 cells by immunoelectron microscopy.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:61 (abstract no. 40). Unique Identifier : AIDSLINE PRIM9/1110292; Brown CR; Lewis MG; Martin JE; Norton WN; Benveniste RE; Rippy MK; Zack PM; US Army Medical Research Institute of Infectious Diseases, Fort; Detrick, MD 21702.; AA-2 cells were infected with either SIVMne-E11S or SIVSM-PBj at an MOI of 1 and harvested at day 5 post-inoculation. Cells were pelleted, fixed with 2% paraformaldehyde/0.1% glutaraldehyde, dehydrated, and embedded in either PolyBed 812 epon or L R White resin. Several immunoelectron microscopic (IEM) post-embedment
Kinetics of lymph node infection following SIV inoculation in rhesus macaques.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:62 (abstract no. 41). Unique Identifier : AIDSLINE PRIM9/1120292; Chakrabarti L; Mairie MA; Hurtrel M; Montagnier L; Hurtrel B; Unitae d'Oncologie virale, Institut Pasteur, Paris, France.; Objective: to determine the sequence of events leading to acute infection and subsequent establishment of latency in lymph nodes of SIV infected rhesus macaques. Methods: Lymph nodes were obtained from 10 infected rhesus macaques that were sacrificed at days 7, 15, 30, 56, 65, 78, 98, and 105 following inoculation wit
Macrophages as early targets and reactivatable reservoirs of SIVsmmPBj14 in macaques.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:63 (abstract no. 42). Unique Identifier : AIDSLINE PRIM9/1130292; Israel ZR; Dean GA; Dow SW; O'Neil SP; Maul DH; Mullins JI; Fultz PN; Hoover EA; Department of Pathology, Colorado State University, Fort Collins,; CO 80523, USA.; Macrophages are a major reservoir of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) in the tissues of infected humans and macaques respectively. These studies were initiated to investigate the early target cells of SIVsmmPBj14-1.9 and were prompted by our observation that circulating monocy
Analysis of early intestinal abnormalities in SIV-infected rhesus macaques: a prospective study.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:64 (abstract no. 43). Unique Identifier : AIDSLINE PRIM9/1140292; Heise C; Vogel P; Lackner A; Halsted C; Dandekar S; Dept of Internal Medicine and California Primate Research Center,; University of California, Davis, CA 95616.; The goals of our research are to study pathogenic mechanisms of SIV-associated gastroenteropathy and the development of clinical malabsorption in rhesus macaques. A retrospective study of intestinal tissues from 15 SIV-infected rhesus macaques indicated a depression of jejunal brush border enzyme activities in all inf
Serum antibodies from macaques infected with SIV251 and SIV239 do not enhance receptor mediated endocytosis by macaque macrophages.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:65 (abstract no. 44). Unique Identifier : AIDSLINE PRIM9/1150292; Jolly PE; Hildreth J; Narayan O; Johns Hopkins University School of Medicine, Baltimore, MD.; Anitbody dependent enhancement (ADE) of infection by the human and simian immunodeficiency viruses (HIV and SIV) in human monocytic and lymphocytic cell lines has been reported by several investigators. In these studies enhancement occurred either by means of Fc receptor (FcR) or complement receptor (C R) mediated end
A whole blood assay for in vitro suppression of viral replication correlates with CD8+ lymphocyte medicated suppression assay in a comparison of 2 groups of SIV infected rhesus macaques.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:66 (abstract no. 45). Unique Identifier : AIDSLINE PRIM9/1160292; Lohman BL; Marthas ML; Pedersen NC; California Regional Primate Research Center, University of; California, Davis, CA.; CD8+ lymphocyte mediated supression of viral replication has been presented as a possible mechanism of aviremia in SIV infection. We developed a quick and inexpensive method for in vitro screening of SIV infected macaques for suppression of SIV replication. Briefly, washed whole blood from SIV-infected monkeys was inf
Hematologic changes in rhesus macaques experimentally infected with simian immunodeficiency virus (SIV).: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:67 (abstract no. 46). Unique Identifier : AIDSLINE PRIM9/1170292; Mandell CP; Jain NC; Lackner AA; Dandekar S; Department of Clinical Pathology, California Primate Research; Center and Department of Internal Medicine, University of; California, Davis, CA.; The objectives of the present study were to characterize the development of hematologic abnormalities in SIV-infected rhesus macaques and to identify cellular targets of SIV infection in bone marrow. Three groups of rhesus macaques, 8 monkeys each were inoculated with 1 of 3 SIV: group 1 was inoculated with an unclone
Long-term culture of rhesus macaque T lymphocytes and SIV-specific cytotoxic T lymphocyte (CTL) responses to autologous T cells infected with SIV.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:68 (abstract no. 47). Unique Identifier : AIDSLINE PRIM9/1180292; McGowan E; McChesney M; Virology and Immunology Unit, California Regional Primate; Research Center, University of California-Davis, Davis, CA.; In order to study aspects of the rhesus macaque CTL response to infection with SIV both in vitro and in vivo, we are developing methods to maintain and expand rhesus T lymphocytes in long-term culture. Peripheral blood mononuclear cells (PBMC) are stimulated with Concanavalin A and cultured in RPMI 1640 medium supplem
SIVsmmPBJ14 induced enteropathy in macaques.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:69 (abstract no. 48). Unique Identifier : AIDSLINE PRIM9/1190292; Mossman SP; O'Neil SP; Israel ZR; Maul DH; Dandekar S; Mullins JI; Fultz PN; Hoover EA; Department of Pathology, Colorado State University, Fort Collins,; CO 80523, USA.; Pigtail and cynomolgus macaques inoculated with SIVsmmPBj14 clone 1.9 undergo an acute infection characterised by profuse diarrhea, lymphadenopathy, fever and skin rash. The acute symptoms appear at about 7 days post infection and are resolved within 14 days, provided intravenous rehydration therapy is administered. T
Early morphological changes of thymus and lymph nodes during SIVmac251-infection of M. mulatta.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:70 (abstract no. 49). Unique Identifier : AIDSLINE PRIM9/1200292; Muuller IG; Schindler C; Krenn V; Kneitz C; Kerkau T; Schmausser B; Rethwilm A; Stahl-Hennig C; terMuelen V; Muuller-Hermelink HK; Inst. of Pathology, University of Wurzburg.; For the question of the pathogenesis of AIDS, lymph nodes and thymi of juvenile rhesus monkeys were morphologically investigated. Six juvenile monkey were investigated 1, 3, 6, 12, 24 and 30 weeks post intravenous infection with SIVmac251 and compared to three control animals and 6 animals of the terminal phase of inf
Natural killer activity in early and chronic SIV infection.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:71 (abstract no. 50). Unique Identifier : AIDSLINE PRIM9/1210292; O'Reilly KL; Hoover EA; Department of Pathology, Colorado State University, Fort Collins,; CO 80523, USA.; Natural killer (NK) cell activity of peripheral blood mononuclear cells from infected and uninfected pig-tailed (Macaca nemestrina) and rhesus (Macaca mulatta) macaques was examined using K562 and Raji cell targets in chromium release assays. As previously described (Vowels et al, AIDS Res Human Retroviruses 6:950, 19
Transmission of simiam immunodeficiency virus (SIV) in naturally infected African green monkeys (AGMs).: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:72 (abstract no. 51). Unique Identifier : AIDSLINE PRIM9/1220292; Otsyula M; Ochiago O; Suleman M; Gettie A; Isahakia M; Marx PA; Institute of Primate Research, PO Box 24481, Nairobi, Kenya.; To determine the mode of transmission of SIV in a breeding colony of AGMs (cercopithecus aethiops), 150 sera were screened for antibodies by ELISA and western blot. Thirty-six (25%) animals were seropositive and SIV was isolated from 15 of 36. Subsequently, virus positive and seronegative adults were used to form 8 ha
The accumulation of viral DNA in the peripheral blood mononuclear cells of simian immunodeficiency virus-infected rhesus macaques.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:73 (abstract no. 52). Unique Identifier : AIDSLINE PRIM9/1230292; Ramos RA; Unger R; Marthas M; Van Rompay K; Lackner A; Pedersen NC; Department of Medicine, School of Veterinary Medicine, University; of California, Davis, CA.; The simian immunodeficiency virus (SIV) causes an AIDS-like disease in rhesus macaques (Macaca mulatta). Several molecular clones of SIV are infectious, however, not all clones are capable of inducing simian AIDS (SAIDS). Experimental infection of macaques with SIVmac239 causes fatal disease in approximately half of t
Pathogenesis of HIV-2 infection in macaque species.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:74 (abstract no. 53). Unique Identifier : AIDSLINE PRIM9/1240292; Morton WR; Schmidt AM; McClure J; Hu SL; Gale M; Kuller L; Regional Primate Research Center, University of Washington,; SJ-50, Seattle, WA, USA.; Human immunodeficiency virus type (HIV-2) has a high degree of homology to the simian immunodeficiency virus (SIV), which has been shown to cause AIDS in several species of nonhuman primates. We have identified two subgroups of HIV-2 that have differing degrees of cytopathogenicity to macaque peripheral blood mononucl
SIV detected in progenitor enriched CD4 depleted bone marrow.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:75 (abstract no. 54). Unique Identifier : AIDSLINE PRIM9/1250292; Beltz LA; Narayan O; Adams RJ; Thoburn CJ; Noga SJ; Donnenberg AD; The Johns Hopkins University, School of Medicine, Baltimore, MD; 21205.; Infection with SIV results in changes in BM clonogenicity and peripheral blood composition. We have previously provided evidence that SIV can be recovered from long term cultures of progenitor enriched bone marrow obtained late after infection with SIV251. To further define which BM populations host SIV in vivo, we ha
Identification of viral determinants of macrophage tropism for simian immunodeficiency virus (SIVmac).: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:76 (abstract no. 55). Unique Identifier : AIDSLINE PRIM9/1260292; Banapour B; Marthas ML; Ramos RA; Gardner MB; Pedersen NC; Luciw PA; Department of Medical Pathology, University of California, Davis,; CA; In a previous report, we demonstrated that two molecular clones of SIVmac, SIVmac-1A11 and SIVmac-239, show differential tropism for macrophages (Banapour et al. Virology 183:12-19, 1991). To map the viral determinants of macrophage tropism, reciprocal recombinant genomes were constructed between these two clones. Inf
Simian immunodeficiency virus (SIV)-cell interactions in vitro: productive SIV infection is enhanced in large vessel aortic and central nervous system (CNS) white matter and testis gradient purified microvascular endothelial cells (EC).: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:77 (abstract no. 56). Unique Identifier : AIDSLINE PRIM9/1270292; Brooks BR; Madden R; Stone CM; Schultz KT; Panganiban A; Eckdahl T; Neurology and Research Services, William S Middleton Memorial VA; Hospital, Madison, Wisconsin.; The CNS pathology that may be associated with SIV infection of primates is prominent in the cerebral white matter compared with cerebral cortex or cerebellum. Murine neurotropic retroviruses demonstrate regional differences in the virus growth curve and cytopathogenesis in vitro between EC and other cell types derived
Monocyte infection and lymphocyte subset alterations in acute SIVsmmPBj14 infection.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:78 (abstract no. 57). Unique Identifier : AIDSLINE PRIM9/1280292; Dean GA; Maul DH; Mullins JI; Fultz PN; Hoover EA; Department of Pathology, Colorado State University, Fort Collins,; CO 80523 USA.; Simian immunodeficiency virus (SIV) sooty mangabey (SMM) strain PBj14 has been shown to infect macaques and induce disease with one of two outcomes: (1) acute enteric disease resulting in death, or (2) survivable acute-phase disease followed by chronic asymptomatic infection. To better understand the acute phase of SI
CD4-depleted, SIV-infected macaques have attenuated granulomatous responses.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:80 (abstract no. 59). Unique Identifier : AIDSLINE PRIM9/1290292; Horvath CJ; Hunt RD; Sehgal PK; Ringler DJ; Harvard Medical School, New England Regional Primate Research; Center, Box 9102, Southborough, Mass., 01772-9102, USA.; Granulomatous inflammation was studied in two control rhesus monkeys and two asymptomatic, SIV-infected animals with low (less than 14%) CD4+ blood lymphocyte (LC) counts. Complete Freund s adjuvant (.5 ml) was injected subcutaneously in two sites and a resulting nodule removed 11 and 24 days later for histologic and
A sensitive microplate assay for the titration of neutralizing antibodies against SIV and HIV-2.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:81 (abstract no. 60). Unique Identifier : AIDSLINE PRIM9/1300292; Le Grand R; Vogt G; Vaslin B; Dormont D; SSA/DPTE/DSV/CEA, BP6, 92265 Fontenay aux Roses, France.; Objective: To devlop a simple, quantitative and high sensitive assay for the titration of the neutralizing properties of sera from SIV or HIV-2 infected and/or vaccinated rhesus monkeys. Method: In a 96 wells microplate, and in a total volume of 50 microliter of PBS supplemented with 10% of a heat complement depleted
Natural killer (NK) cell activity in SRV-2/WA seronegative and seropositive pigtailed macaques (M. nemestrina).: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:83 (abstract no. 62). Unique Identifier : AIDSLINE PRIM9/1310292; Maggio-Price L; Shiota F; Moazed TC; Pollack SB; Departments of Comparative Medicine and Biological Structure; University of Washington, Washington Regional Primate Research; Center, Seattle, WA 98195.; We analyzed natural killer (NK) cell activity in pigtailed macaques (M. nemestrina) that were seronegative (virus negative/antibody negative, V-Ab-) or seropositive (virus negative/antibody positive V-Ab+) for type D retrovirus SRV-2/W (SAIDS retrovirus serotype 2). Peripheral blood lymphocyte preparations were evalua
Mutational analysis of the CD4 binding region of SIV envelope.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:84 (abstract no. 63). Unique Identifier : AIDSLINE PRIM9/1320292; Planelles V; Leung NJ; Unger RE; Haigwood NL; Scandella C; Misher L; Gardner MB; Luciw PA; University of California, Davis, CA 95616.; A transient expression system for SIV envelope surface glycoprotein (gp130) in Cos cells was developed. This system yields glycosylated recombinant gp130 that binds to soluble CD4. A panel of mutant SIV envelope constructs was created by site-directed mutagenesis and the corresponding glycoproteins were expressed and
Characterization of the neutralization mechanism of antibodies specific for the envelope glycoprotein of SRV.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:86 (abstract no. 65). Unique Identifier : AIDSLINE PRIM9/1330292; Torres JV; Malley A; Anderson DE; Benjamini E; Department of Medical Microbiology and Immunology, School of; Medicine, University of California, Davis, CA, 95616.; Simian Retroviruses (SRV) are type D viruses which induce immunodeficiency in several species of old world monkeys. Five different serotypes of SRV have been identified. The syndrome caused by SRV is very similar to AIDS induced by SIV in monkeys and HIV in humans, including clinical features, tissue tropism and cytop
Influence of SIVmac gp120 variable regions on recognition by neutralizing monoclonal antibodies.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:87 (abstract no. 66). Unique Identifier : AIDSLINE PRIM9/1340292; Collignon C; Burns DP; Kent K; Stott J; DeWilde M; Thiriart C; Desrosiers RC; New England Regional Primate Research Center, Harvard Medical; School, Southborough, MA USA.; Monoclonal antibody-secreting hybridomas were isolated from mice immunized with recombinant vaccinia virus expressing SIVmac251 gp150. Six monoclonal antibodies that recognized gp120 (SU) were found to neutralize SIVmac infectivity. These six neutralizing monoclonal antibodies (NMAbs) fell into at least three distinct
Early SIV replication in resting and activated macaque T lymphocytes.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:88 (abstract no. 67). Unique Identifier : AIDSLINE PRIM9/1350292; Firpo PP; Liang A; Clark E; University of Washington, Primate Center, Seattle, Washington.; The simian immunodeficiency virus (SIV) is tropic for T cells expressing on their surface the CD4 molecule which serves as a receptor for SIV, through its interaction with a component of the viral envelope glycoprotein. The factors which influence the susceptibility of resting CD4+ T cells to SIV entry activation of r
Molecular analysis of type D simian retrovirus serotype 2 (SRV-2) from pigtailed macaques with retroperitoneal fibromatosis.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:89 (abstract no. 68). Unique Identifier : AIDSLINE PRIM9/1360292; Grant R; Malinak C; Wu H; Tsai CC; University of Washington Regional Primate Research Center,; Seattle, WA.; Retroperitoneal fibromatosis (RF) is a fibromatous neoplasm associated with type D simian retrovirus serotype 2 (SRV-2) infections. RF in macaques has many similarities to Kaposi s sarcoma (KS) in humans, and SRV-2-associated RF is currently being studied as a model for AIDS-associated KS. SRV-2/WA isolated from macaq
Analysis of the immunogenicity of SIVmac251 gp120 using hybrid Ty-VLPS.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:90 (abstract no. 69). Unique Identifier : AIDSLINE PRIM9/1370292; Stenner N; Almond N; Kitchin P; Mills K; Kingsman S; Kingsman A; Adams S; British Bio-technology Ltd., Watlington Road, Oxford.; The SIV macaque model is currently being developed at several centres worldwide in order to improve our understanding of the processes of infection and protective immune responses against primate lentiviruses. Considerable progress has been made in this area by the demonstration of protection against SIV using fixed,
Molecular cloning and restriction endonuclease mapping of simian AIDS type D retrovirus serotype 2 and variant.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:91 (abstract no. 70). Unique Identifier : AIDSLINE PRIM9/1380292; Horenstein G; Kelley RD; Malley A; Shiigi SM; Hallick LM; Axthelm MK; Machida CA; Departments of Microbiology, Oregon Health Sciences University,; Portland, Oregon 97201.; Type D simian retrovirus (SRV) infection is the cause of most Simian Acquired Immunodeficiency Syndrome (SAIDS)-associated mortality in biomedical research colonies of Asian macaques. SAIDS in macaques at the ORPRC has been associated with three distinct serogroups of type D SRVs: D1/RHE/OR associated with severe immu
The cytoplasmic domain of the transmembrane protein of SIVmac239 is not necessary for virus infectivity.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:92 (abstract no. 71). Unique Identifier : AIDSLINE PRIM9/1390292; Johnston P; Hunter E; University of Alabama at Birmingham, Department of Microbiology,; Birmingham, AL 35294.; SIVmac239, a pathogenic molecular clone of SIV, is unusual in that the cytoplasmic domain of the TM protein is not truncated. Upon passage of the virus in human cells, spontaneous mutations within this region result in translation termination and synthesis of a smaller, 28kd, TM protein. In this study, we have introdu
Analysis of pathogenic and non-pathogenic molecular clones of simian immunodeficiency virus.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:93 (abstract no. 72). Unique Identifier : AIDSLINE PRIM9/1400292; Luciw PA; Shaw KE; Unger RE; Planelles V; Stout MW; Leung NJ; Banapour B; Marthas ML; Department of Medical Pathology and the California Regional; Primate Research Center, University of California, Davis, 95616.; Two molecular clones of simian immunodeficiency virus (SIVmac) have been characterized extensively in vivo and in vitro. SIVmac239 causes an AIDS-like disease in macaques; SIVmac1A11 does not produce disease. Infection of rhesus macaques with SIVmac239 results in persistent viremia. Infection by SIVmac1A11 results in
Cis-acting regulatory regions of simian foamy virus type 1.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:94 (abstract no. 73). Unique Identifier : AIDSLINE PRIM9/1410292; Mergia A; Pratt-Lowe E; Shaw KE; Luciw PA; Department of Medical Pathology, Davis, University of California; 95616.; The three subfamilies of retroviruses are oncoviruses, lentiviruses and spumaviruses. The latter, also designated foamy or syncytium-forming viruses, are found in a variety of species, including humans, and are highly cytopathic in tissue culture systems. In the host, spumaviruses appear to establish latency; a clear
Tissue distribution of proviral SRV-2/W in naturally infected M. nemestrina.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:95 (abstract no. 74). Unique Identifier : AIDSLINE PRIM9/1420292; Moazed TC; Thouless ME; Department of Pathobiology, University of Washington, Seattle, WA; 98915.; Simian immune deficiency syndrome (SAIDS) in pigtailed macaques (M. nemestrina) at the University of Washington Regional Primate Research Center (UWRPRC) is caused by a type D retrovirus, SRV-2/W (SAIDS Retrovirus serotype 2). SRV-2/W infection causes a transient viremia (V+) detectable by Raji co-cultivation of perip
Complex determinants of macrophage tropism in env of SIV.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:96 (abstract no. 75). Unique Identifier : AIDSLINE PRIM9/1430292; Mori K; Ringler DJ; Kodama T; Desrosiers RC; New England Regional Primate Research Center, Harvard Medical; School, Southborough, MA USA.; Virus derived from a molecular clone of SIVmac239 causes AIDS and death in about 40% of infected rhesus monkeys within six months. The other 60% develop a more protracted disease course that also closely resembles AIDS in humans. Cloned SIVmac239 replicates very poorly in primary rhesus monkey alveolar macrophage cult
Comparative survey by serology, virus isolation, and polymerase chain reaction of a cohort of infected chimpanzees.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:97 (abstract no. 76). Unique Identifier : AIDSLINE PRIM9/1440292; Jett CM; Murthy KK; Henrard DR; Eichberg JW; Southwest Foundation for Biomedical Research, San Antonio, TX.; The polymerase chain reaction (PCR) is a rapid and sensitive method for detecting proviral HIV DNA in cells, and is being evaluated as an additional diagnostic method for use in determining infection status of individuals with indeterminant serology. Examining a population of chimpanzees (n=35) with known dates of inf
Genome organization and expression of simian foamy virus type 3 (SFV-3).: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:98 (abstract no. 77). Unique Identifier : AIDSLINE PRIM9/1450292; Renne R; Friedl E; Schweizer M; Fleps U; Turek R; Neumann-Haefelin D; Abt. Virologie. Inst. f. Med. Mikrobiologie und Hygiene,; Universitaet Freiburg, Hermann-Herder-Str. 11, D-7800 Freiburg,; Germany.; The complete nucleotide sequence of simian foamy virus strain LK-3 (SFV-3), isolated from an African green monkey, was determined. In addition to translation frames representing the gag, pol, and env genes, three open reading frames are located in the region between the env gene and the 3 long terminal repeat (LTR).
A naturally attenuated SIVmac32H variant?: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:99 (abstract no. 78). Unique Identifier : AIDSLINE PRIM9/1460292; Rud EW; Yon J; Cranage MP; Cook N; Larder BA; Clarke BE; Wellcome Research Laboratories, Department of Molecular Sciences,; Beckenham, Kent, UK.; Molecular clones of SIVmac32H were generated in order to make molecularly defined virus available for vaccine challenge and pathogenesis studies. Total cellular DNA was extracted from JM cells infected with the 11/88 pool of SIVmac32H, EcoRI digested and cloned into Lambda Dash (Stratagene). Two clones were found to b
Polymerase chain reaction for direct diagnosis of SRV infection in macaque lymphocytes.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:100 (abstract no. 79). Unique Identifier : AIDSLINE PRIM9/1470292; Swenson RE; Thouless ME; University of Washington Regional Primate Research Center SJ-50; and Dept of Pathobiology SC-38, University of Washington,; Seattle, WA 98195.; The University of Washington Regional Primate Research Center has been using conventional virus isolation techniques to diagnose simian D-Type retrovirus (SRV) infections. The procedure is expensive and time consuming, and the results take up to a month to obtain. The use of the polymerase chain reaction (PCR) to dete
Detection of STLV-1 sequences by PCR in normal and lymphomatous monkey tissues.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:101 (abstract no. 80). Unique Identifier : AIDSLINE PRIM9/1480292; Voevodin AF; De BK; Griffits K; Luciw P; AIDS Control Center of Russian Federation, Moscow, USSR.; The seroepizootiology of HTLV-1 related baboon virus in hamadryas baboons of lymphoma-prone and lymphoma-free populations and individual site-specific monoclonal integration of this STLV-1 in baboon lymphoma were described previously (Voevodin et al., Int. J. Cancer, 1985,36,579; Modern Trends in Human Leukemia VII, 1
Influence of the infectious dose of SIV on the acute infection in cynomolgus monkeys and on the effect of treatment with 3'-fluorothymidine.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:102 (abstract no. 81). Unique Identifier : AIDSLINE PRIM9/1490292; Bottiger D; Oberg B; Department of Virology, Karolinska Institute; Stockholm, SWEDEN.; Objective: To study whether the infectious dose of simian immunodeficiency virus (SIVsm) influences the acute infection and the response to antiviral treatment of 3 -fluorothymidine (FLT). Methods: Cynomolgus monkeys treated s.c. with FLT (3 x 5 mg/kg/d for 10d) were inoculted with 3 different doses of SIVsm i.v. and
In utero inoculation of rhesus monkey fetuses with the simian immunodeficiency virus: a model for pediatric AIDS.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:103 (abstract no. 82). Unique Identifier : AIDSLINE PRIM9/1500292; Fazely F; Sharma PL; Greene MF; Wyand MS; Memon M; Letvin N; Ruprecht RM; Laboratory of Viral Pathogenesis, Dana-Farber Cancer Institute &; Harvard Medical School, Boston, MA.; SIV infection of rhesus monkeys closely resembles HIV-1 infection in humans, except that maternal transmission rarely, if ever, occurs in rhesus monkeys. Thus, the low transmission rate in this animal model may pose difficulties in studying lentiviral infections in the perinatal period. To circumvent the problem of lo
Evidence for autoimmune hemolysis in all macaques studied with end stage simian immunodeficiency virus (SIV) infection: an important etiology of anemia.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:104 (abstract no. 83). Unique Identifier : AIDSLINE PRIM9/1510292; Hillyer CD; Hall JM; Ansari AA; McCLure HM; Department of Pathology and the Winship Cancer Center, Emory; University School of Medicine, and Yerkes Regional Primate; Research Center, Emory University, Atlanta, GA.; Forty-nine SIV infected rhesus macaques (RM) were evaluated for autoimmune hemolytic anemia (AIHA); 25 SIV RM served as controls (Group A). The SIV+ RM were divided into 2 groups; Group B (n=35) were well with lymphadenopathy and/or hepatosplenomegaly only and Group C (n=14) were sick with weight loss, diarrhea, sever
Significant bone marrow abnormalities in SIVsmm infected rhesus macaques: analysis of aspirates and biopsies.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:105 (abstract no. 84). Unique Identifier : AIDSLINE PRIM9/1520292; Klumpp SA; Hillyer CD; Olberding BA; McClure HM; Yerkes Regional Primate Research Center, Emory University,; Atlanta, GA.; Reported abnormalities of the bone marrow from HIV infected persons include hypercellularity, megaloblastic hematopoiesis, reticuloendothelial iron blockade, myelodysplasia, myelofibrosis, serous atrophy of fat, plasmacytosis, lymphocytic aggregates, neoplasia and granulomas. To compare these findings with bone marrow
Normal erythropoietin (EPO) response observed in anemic SIVsmm infected rhesus macaques.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:106 (abstract no. 85). Unique Identifier : AIDSLINE PRIM9/1530292; Hillyer CD; Klumpp SA; McClure HM; Department of Pathology and the Winship Cancer Center, Emory; University School of Medicine, and Yerkes Regional Primate; Research Center, Emory University, Atlanta, GA.; An inadequate EPO response to anemia has characterized some human subjects infected with the human immunodeficiency virus, especially those patients taking zidovudine and has led to approval of recombinant EPO in the treatment of AIDS-associated anemia. AS SIV infected rhesus macaques have an anemia of uncertain etiol
Immunologic changes in the early stages of SIVmac infected infected rhesus monkeys.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:107 (abstract no. 86). Unique Identifier : AIDSLINE PRIM9/1540292; Kerkau T; Kneitz C; Sauer U; Muuller J; Duorries R; Stahl-Henning C; Coulibaly C; Hunsmann G; Fleckenstein B; Muuller-Hermelink HK; et al; Institute of Virology and Immunobiology University of Wirzburg,; Germany.; Objective: The aim of our study was to perform a quantitiative and functional analysis of different lymphocyte populations in the early stages of SIVinfected rhesus monkeys. Methods: Juvenile rhesus monkeys, approximately 2.5 - 3 years of age were immunised with KLH and 6 weeks later experimentally infected with SIVma
Potential heterosexual transmission of SIVMne in macaca nemestrina.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:108 (abstract no. 87). Unique Identifier : AIDSLINE PRIM9/1550292; Kuller L; Watanabe R; Benveniste RE; Morton WR; Regional Primate Research Center, University of Washington SJ-50,; Seattle, WA 98195.; A pregnant adult M. nemestrina was inoculated intravenously with 1x10(3) TCID wild type SIVMne for use in a fetal-transmission study and following delivery returned to a normal menstral cycle. Due to the decreased availability of pregnant animals for maternal-fetal transmission studies, a study was undertaken to deter
Retroviral infection in different monkey species.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:109 (abstract no. 88). Unique Identifier : AIDSLINE PRIM9/1560292; Lapin BA; Klots IN; Harashvili; Rezikyan SA; Institute of Experimental Pathology and Therapy, Sukhumi, USSR.; Institute of Experimental Pathology and Therapy (IEPT) is now keeping more than 6,000 monkeys. The main species are Baboons (Papio hamadryas), Rhesus monkey (Macaca mulatta), Cynomolgus monkeys (Macaca fascicularis) and African green monkeys (Cercopithecus aethiops). Annually IEPT imports a lot of monkeys from the wil
Horizontal transmission of SIVstm among group-housed juvenile male rhesus.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:110 (abstract no. 89). Unique Identifier : AIDSLINE PRIM9/1570292; Lowenstine LJ; Jennings MB; Yee JL; Vogel AP; Scott L; Lerche NW; Hendrickx AG; Department of Patholog and California Regional Primate Research; Centers, University of California, Davis, CA 95616.; The mode of transmission of SIV among nonhuman primates is unknown. In sooty mangabeys it is thought to be sexual or mother to infant. A propagating epizootic of SIV occurred in the 1970 s at the California Regional Primate Research Center that appeared to spread horizontally among stump-tailed macaques. This study wa
Simian T-cell leukemia virus infection in a captive baboon colony: a model for human T-cell leukemia virus type-I infection and pathogenesis.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:111 (abstract no. 90). Unique Identifier : AIDSLINE PRIM9/1580292; Mone J; Hubbard G; Leland M; Allan JS; Department of Virology and Immunology, Southwest Foundation for; Research, San Antonio, Texas.; The baboon is an old-world primate species which is a natural host for simian T-cell leukemia virus type-1 (STLV-I), a virus very similar to human T-cell leukemia virus type-1 (HTLV-I), the etiologic agent of adult T-cell leukemia. Despite the clinical importance of HTLV-I, little is known concerning the pathogenesis
The prognostic significance of SIV p27 antibody levels in SIV infected macaques.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:112 (abstract no. 92). Unique Identifier : AIDSLINE PRIM9/1590292; Pearlman S; Charie L; Toedter G; Hofheinz D; Letvin N; Coulter Immunology, Hialeah, Florida.; Declining levels or the absence of antibody to core antigens has been associated with the progression of disease in both SIV-1 infected macaques and in HIV-1 infected humans. Monitoring of anti-core antibodies can thus be of value in studies involving treatment or vaccines. A commercially available SIV p27 antigen ass
Immunohistochemical localization of type D SAIDS retrovirus serotype 2 (SRV-2) in the digestive system of pigtailed macaques with retroperitoneal fibromatosis.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:113 (abstract no. 93). Unique Identifier : AIDSLINE PRIM9/1600292; Tsai CC; Wu H; Regional Primate Research Center, University of Washington,; Seattle, WA 98195.; Simian acquired immunodeficiency syndrome (SAIDS) in pigtailed macaques (Macaca nemestrina) at the Washington Regional Primate Research Center is an endemic disease caused by a type D SAIDS retrovirus serotype 2 (SRV-2). SRV-2 has been identified as an important etiological agent for morbidity and mortality in the pig
Pneumocystis carinii (PC) pneumonia in SIV-infected rhesus macaques.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:114 (abstract no. 94). Unique Identifier : AIDSLINE PRIM9/1610292; Vogel AP; Lerche NW; Miller CJ; Lowenstine LJ; Walls JE; Lackner AA; Virology and Immunology Unit, CRPRC, U C Davis, CA.; Pneumocystis carinii pneumonia (PCP) remains the leading life-threatening opportunistic infection in AIDS. It is not clear whether PCP in immunosuppressed patients results from a reactivation of latent infection, a primary infection with pathogenic subtypes or a simple reinfection. Formalin-fixed paraffin-embedded tis
Immunologic response to Toxoplasma in immunocompetent and SIV-infected rhesus macaques.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:115 (abstract no. 95). Unique Identifier : AIDSLINE PRIM9/1620292; Warren JJ; Morton WR; Fritsche TR; Department of Laboratory Medicine and Regional Primate Research; Center, University of Washington, Seattle, Washington, USA.; Evaluation of the immune responses to Toxoplasma gondii during acute and reactivation stages of infection is the central focus of work begun on the development of a nonhuman primate model of toxoplasmic encephalitis (TE). Six male rhesus macaques have been monitored post infection for Toxoplasma specific IgG, IgM, and
A new method to detect SIV neutralizing antibodies in macaques: comparison of neutralization of wild type virus and a biological clone.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:116 (abstract no. 96). Unique Identifier : AIDSLINE PRIM9/1630292; Welch MJ; Thouless ME; University of Washington, Seattle, Washington. USA.; The simian immunovirus (SIV) macaque model for human immunodeficiency virus (HIV) infection is used in order to gain understanding of the host immune responses, and for the development of HIV vaccine strategies. The role of neutralizing antibodies in delaying the progression of AIDS is not well understood, but because
Diagnostic methods for determining simian retrovirus type D (SRV) serological and virological status of macaque monkeys.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:117 (abstract no. 97). Unique Identifier : AIDSLINE PRIM9/1640292; Yee JL; Jennings MB; Cotterman R; Vertti T; Ishizaki G; Lerche NW; Department of Medical Pathology, University of California, Davis.; Simian Retrovirus Type D (SRV) infects and causes an immunosuppressive disease in captive and wild macaque monkeys. The overall seroprevalence of this virus is 5-7%; and the mortality rate is 30-50%. Direct contact between infected and susceptible animals, or direct parenteral exposure to infectious blood or tissues c
Differential serology of SIV.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:118 (abstract no. 98). Unique Identifier : AIDSLINE PRIM9/1650292; Munaf A; Parker D; McClure M; Cranage M; Weber J; St. Mary's Hospital Medical School, London, UK.; Gene fragments encoding SIV proteins were generated by PCR amplification using a molecular clone of SIVmac251 (pBK28 from NEPRC) as a template. Five proteins have been expressed as B-galactosidase fusion proteins, expressed in E.coli. These are env gp32 (transmembrane); gag p27; full length pol; full length tat and ne
SIV vaccine protection of rhesus macaques.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:119 (abstract no. 100). Unique Identifier : AIDSLINE PRIM9/1660292; Jennings MB; Rosenthal A; Yee J; Schmerl S; Carlson JR; Gardner MB; Department of Pathology, School of Medicine, University of; California, Davis.; Rhesus macaques (M. mulatta) immunized with an inactivated whole SIVmac vaccine and muramyl dipeptide (MDP) have been protected against intravenous challenge with cell-free SIVmac and later with cell-free SIVsmm. The role of humoral immunity in the mechanism of protection and protection against cell-associated virus c
Immune response of rhesus macaques to recombinant SIVmac gp130.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:120 (abstract no. 101). Unique Identifier : AIDSLINE PRIM9/1670292; Giavedoni LD; Heigwood N; Ahmad S; Planelles V; Marthas M; Kluge JD; Gardner M; Luciw P; Yilma T; University of California, Davis, CA 95616.; The surface glycoprotein (pg130) of the Simian Immunodeficiency Virus (SIV), strain 1A11, was expressed in CHO cells (CHOgp130), vaccinia virus (vSIVgp130), and baculovirus (Bacgp130). Two groups of rhesus macaques (four/group) were vaccinated with vSIVgp130 by intradermal inoculation and scarification with 10(8) pfu
Vaccine protection of rhesus macaques against SIVmac infection by high but not low doses of inactivated whole SIVmac immunogen.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:121 (abstract no. 102). Unique Identifier : AIDSLINE PRIM9/1680292; Hartung S; Norley S; Bourquin P; Ennen J; Kurth R; Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51 - 59, 6070 Langen.; Eight Rhesus macaques were immunized intramuscularly four times (0, 1, 2, 4 months) over a period of 4 months with a formalin inactivated whole SIV vaccine in the presence of muramyl dipeptide (MDP) as adjuvant. Four animals received 0.5 mg and the other four 0.1 mg immunogen per injection. Three weeks after the final
Immunization of rhesus monkeys with synthetic peptide corresponding to CD4-binding site of the HIV-2 gp120.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:122 (abstract no. 104). Unique Identifier : AIDSLINE PRIM9/1690292; Lapin BA; Klots IN; Institute of Experimental Pathology and Therapy of the Academy of; Medical Science, Sukhumi, USSR.; The present study was undertaken to determine whether rhesus monkeys were capable of generating specific neutralizing antibody responses after immunization with synthetic peptide corresponding to CD4-binding site of the HIV-2 gp120. Peptide consisting of 32 amino acid residues was chemically synthesized and purified o
Neutralizing domain in the external enveope glycoprotein of SIVmac251.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:123 (abstract no. 105). Unique Identifier : AIDSLINE PRIM9/1700292; Benichou S; Legrand R; Nakagawa N; Vogt G; Faure T; Dormont D; Tiollais P; Kieny MP; Madaule P; Unitae de Recombinaison et Expression Gaenaetique, Institut; Pasteur, Paris.; Two murine monoclonal antibodies (MAbs), designated MATG2014 and MATG2033, were generated. They are reactive with the external envelope glycoprotein gp105 of the simian immunodeficiency virus of macaque monkey (SIVmac251), and display a cell-free virus neutralizing activity in vitro. Epitope mapping of these MAbs was
T cell epitopes on the envelope glycoproteins of simian retrovirus 1 and 2.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:124 (abstract no. 106). Unique Identifier : AIDSLINE PRIM9/1710292; Malley A; Torres J; Benjamini E; Pangares N; Axthelm K; Oregon Regional Primate Research Center, Beaverton, OR.; The T cell proliferative responses of Rhesus and Celebes macaques and several mouse strains immunized with SRV-1 and SRV-2 virus were used to define the T cell epitopes of their respective envelope glycoproteins. Monkey peripheral blood lymphocytes (PBL) (2.5x10(5) cells/well) or murine spleen cells (5x10(5)/well) wer
Induction of SIV-specific local mucosal immunity with a killed-virus oral vaccine.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:125 (abstract no. 107). Unique Identifier : AIDSLINE PRIM9/1720292; Marx PA; Eldridge JH; Gettie A; McGhee J; Kiyono H; Compans R; Div of Virol. and Immunol., New Mexico Regional Primate Research; Laboratory, New Mexico State Univ., Holloman AFB, NM.; Induction of local immunity remains an important issue in the development of simian immunodeficiency virus (SIV) vaccines. Research with mice suggests that microencapsulated vaccines may induce both local and systemic immunity in rhesus macaques. To test this hypothesis, 12 rhesus macaques were immunized with microenc
Compliance of a whole killed SIV vaccine with a checklist for a working vaccine for AIDS.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:126 (abstract no. 108). Unique Identifier : AIDSLINE PRIM9/1730292; Murphey-Corb M; Ohkawa S; Davison-Fairburn B; Martin L; Tulane Regional Primate Research Center, Covington, LA.; An ideal working vaccine for AIDS should fulfill the following objectives: 1) Prevent the establishment of infection 2) Have a broad specificity 3) Induce long-term immunity 4) Protect against the virus-infected cell as well as free virus 5) Induce immunity at mucosal surfaces. Using SIV as a prototype, we have determ
Comparison of mucosal vs. intravenous infectious dose of a cell associated SIV32H challenge stock in rhesus macaques.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:127 (abstract no. 109). Unique Identifier : AIDSLINE PRIM9/1740292; Niphuis H; Cranage M; Baskerville A; ten Haaft P; Koornstra W; Dubbes R; Heeney JL; Dept. of Chronic and Infectious Diseases, ITRI-TNO, Rijswijk, The; Netherlands.; A rhesus macaque infected with 10 monkey infectious doses (MID50) of the 11-88 stock of SIV32H served as a single source of peripheral blood mononuclear cells (PBMCs) and plasma taken at a single time point to establish a cell associated virus stock for homologous or heterologous vaccine challenge. At the time of coll
Immunological analysis of hepatitis B core antigen carrying epitopes from SIVmac251 and HIV-1.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:129 (abstract no. 111). Unique Identifier : AIDSLINE PRIM9/1750292; Yon J; Rud EW; Winsor S; Stapleton M; Bomford R; Rowlands DJ; Francis MJ; Clarke BE; Wellcome Research Laboratories, Department of Molecular Sciences,; Beckenham, Kent, UK, BR3 3BS.; The use of recombinant Hepatitis B core antigen (HBcAG) carrying heterologous protein sequences as potent particulate immunogens is well documented. These chimeric particles have been shown to stimulate both T-cell dependent and independent immune responses. We have introduced peptides from the envelope glycoprotein o
Localization of a neutralization epitope in the envelope glycoprotein (gp130) of SIVmac.: Symp Nonhum Primate Models AIDS. 1991 Nov 6-9;9:131 (abstract no. 113). Unique Identifier : AIDSLINE PRIM9/1760292; Torres JV; Banapour B; Benjamini B; Department of Medical Microbiology and Immunology, School of; Medicine, University of California, Davis, CA 95616.; A neutralization epitope has been localized in the sequence encompassing amino acids 414-433 of the envelope glycoprotein of SIVMAC. Antibodies induced by a synthetic peptide representing this area, neutralize the in vitro infectivity of the virus. Preincubation of SIVMAC molecular clones and biological isolates with
[HIV seropositivity in patients with herpes zoster]: Rev Inst Med Trop Sao Paulo. 1990 Sep-Oct;32(5):364-9. Unique Identifier : AIDSLINE MED/92245308; Vasconcellos MR; Castro LG; dos Santos MF; Disciplina de Dermatologia da Escola Paulista de Medicina,; Hospital das Clinicas, Sao Paulo, Brasil.; Relationship between zoster and seropositivity for HIV is studied. Serum samples from 66 patients presenting acute zoster infection were tested for HIV antibodies, using ELISA. There was no previous selection of patients, what rendered the population studied unbiased. Seven patients (10.6%) were positive for HIV antib
[Decrease of the risk of infection by human immunodeficiency virus (HIV) in patients in hemodialysis in the State of Rio de Janeiro, Brazil]: Rev Inst Med Trop Sao Paulo. 1990 Nov-Dec;32(6):419-27. Unique Identifier : AIDSLINE MED/92245318; Suassuna JH; Rocha PP; de Paiva DR; da Cruz VP; Hospital Universitario Pedro Ernesto, Universidade do Estado do; Rio de Janeiro, Brasil.; The initial surveys on the seroprevalence of anti-HIV-1 antibodies (HIV-Ab) in hemodialysis units in the State of Rio de Janeiro (RJ) were done in 1985. The alarming figures around 15% were ascribed to the poor quality of blood collected from professional donors in exchange for food or money. Recently a concerted effo
[Variants and serotypes of Cryptococcus neoformans in patients with AIDS and neurocryptococcosis in Sao Paulo, Brazil (letter)]: Rev Inst Med Trop Sao Paulo. 1990 Nov-Dec;32(6):480-2. Unique Identifier : AIDSLINE MED/92245327; Calvo B; Fischman O; Pignatari A; Del Bianco R; Zaror L
[Generalized persistent lymphadenopathy syndrome in parenteral drug addicts. Lymph node biopsy study of 41 patients]: An Med Interna. 1990 Dec;7(12):621-6. Unique Identifier : AIDSLINE MED/92248015; Vera-Sempere G; Vera-Sempere FJ; Guix-Garcia J; Departamento de Medicina, Hospital Clinico Universitario,; Valencia.; Of a total of 41 VIH positive patients, parenteral drug addicts, with persistent generalized lymphadenopathy syndrome, we performed 43 lymph-node biopsies. In two sequential biopsies, 2 and 12 months respectively after the first biopsy, were carried-out. After a clinical follow-up (ranging between 4-28 months) 12 pati
[Diabetes mellitus induced by pentamidine, without previous episodes of hypoglycemia, in patients with AIDS]: An Med Interna. 1990 Dec;7(12):637-8. Unique Identifier : AIDSLINE MED/92248019; Santos I; del Arco C; Garcia-Polo I; Noguerado A; Caso E; Gomez-Pan A; Servicio de M. Interna-Infecciosas, Hospital de la Princesa,; Madrid.; The onset of a pneumonia by P. carinii in AIDS patients have force scientist to look for others therapies against this parasite. It is more necessary when the first line treatment which is cotrimoxazol produced secondary effects or not therapeutic effects. Pentamidine which is an agent usually used to treat leishmania
[Candida parapsilosis esophagitis in HIV infected patient (letter)]: An Med Interna. 1990 Dec;7(12):655-6. Unique Identifier : AIDSLINE MED/92248029; Fernandez Horcajuelo J; Fernandez Capitan C; Pascual Gonzalez C; Fernandez Galan MA; Patron Costas G
Training nurses in HIV/AIDS.: Philipp J Nurs. 1990 Oct-Dec;60(4):16-20. Unique Identifier : AIDSLINE MED/92253625; Zaldivar SB
Tuberculosis in high risk reactors.: Bull Int Union Tuberc Lung Dis. 1990-91;66 Suppl:17-9. Unique Identifier : AIDSLINE MED/92248363; Miller B; Division of Tuberculosis Control, Centers for Disease Control,; Atlanta GA 30333.
BCG in subjects infected with HIV.: Bull Int Union Tuberc Lung Dis. 1990-91;66 Suppl:31. Unique Identifier : AIDSLINE MED/92248369; Guerin N; International Children's Centre, Paris, France.
The Tanzania National Tuberculosis/Leprosy Programme in the face of HIV infection.: Bull Int Union Tuberc Lung Dis. 1990-91;66 Suppl:53-5. Unique Identifier : AIDSLINE MED/92248378; Chum HJ; Ministry of Health, Dar-es-Salaam, Tanzania.
Probing the complex issues of AIDS, while waiting for the other shoe to drop [editorial]: Compendium. 1991 Nov;12(11):792-4. Unique Identifier : AIDSLINE MED/92240595; Isler SL
Severe Rhodococcus equi pneumonia: case report and literature review.: Eur J Clin Microbiol Infect Dis. 1991 Sep;10(9):762-8. Unique Identifier : AIDSLINE MED/92241338; Vestbo J; Lundgren JD; Gaub J; Roder B; Gutschik E; Department of Infectious Diseases, Hvidovre Hospital, University; of Copenhagen, Denmark.; Rhodococcus equi is an aerobic, gram-positive, non-motile pleomorphic bacillus infecting immunocompromised patients. Forty-nine cases of Rhodococcus equi infection have been reported, mainly in patients infected with the human immunodeficiency virus (HIV). A case in which Rhodococcus equi caused severe pulmonary infec
Absence of HTLV-I and HTLV-II infection in prostitutes in the area of Seville, Spain.: Eur J Clin Microbiol Infect Dis. 1991 Sep;10(9):773-5. Unique Identifier : AIDSLINE MED/92241341; Calderon EJ; Gomez-Lucia E; Aguado I; Pineda JA; Essex M; Leal M; Department of Internal Medicine, Virgen del Rocio University; Hospital, Seville, Spain.; Infection with human retroviruses other than HIV in Spain has only been reported in isolated cases in African immigrants and intravenous drug abusers infected with HTLV-I. The status of the prostitute population is unknown. The sera of 88 prostitutes in Seville were therefore tested
AIDS and dentistry--an update.: Dent Update. 1991 Jul-Aug;18(6):228-9. Unique Identifier : AIDSLINE MED/92241568; Samaranayake PL; Prince Philip Dental Hospital, University of Hong Kong.; How many patients have been infected with HIV by their dentists? How should the HIV-positive dental student be managed? What impact will the HIV epidemic have in the 1990s? How readily can HIV be transmitted by saliva? All these questions have been the subject of recent reports. Dr Samaranayake provides a summary of t
Preparative separation and analysis of the enantiomers of [3H]Abbott-69992, an HIV anti-infective nucleoside, by ligand-exchange high-performance liquid chromatography.: J Chromatogr. 1991 Nov 22;586(2):265-70. Unique Identifier : AIDSLINE MED/92242396; Thomas SB; Surber BW; Drug Metabolism Department, Abbott Labortories, Abbott Park, IL; 60064-3500.; Several chiral stationary phases (CSPs) were examined to separate the enantiomers of A-69992, a chiral HIV anti-infective nucleoside. The only CSP found to be effective was Nucleosil Chiral-1, a ligand-exchange CSP, which was used to prepare microgram amounts of the enantiomers of high optical purity. This appears to
American Academy of Dermatology Symposium on AIDS. Atlanta, Georgia, Dec. 1, 1990.: J Am Acad Dermatol. 1991 Dec;25(6 Pt 1):1086-91. Unique Identifier : AIDSLINE MED/92242608; Friedman-Kien AE; Harte JS; Department of Dermatology, New York University Medical Center, NY; 10016.
Aggressive periodontal destruction and herpes zoster in a suspected AIDS patient.: J Parodontol. 1991 Nov;10(4):359-69. Unique Identifier : AIDSLINE MED/92243354; Moskow BS; Hernandez G; Center for Clinical Research in Dentistry, School of Dental and; Oral Surgery, Columbia University, New York, N.Y.; An unusual case of spontaneous and rapidly destructive lesions involving the periodontal structures is described in a 54 year old, bi-sexual patients suspected of having AIDS. Concomitant with the periodontal breakdown, the patient developed a severe case of Herpes Zoster involving the area of the face innervated by t
Pathology of bovine leukosis.: Kitasato Arch Exp Med. 1991 Sep;64(2-3):101-14. Unique Identifier : AIDSLINE MED/92243768; Yoshikawa T; Department of Veterinary Pathology, School of Veterinary Medicine; and Animal Sciences, Kitasato University, Aomori, Japan.
Anti-HIV-1: extended validation of a modified gelatin particle agglutination assay, and its use with an image analyser.: Med Lab Sci. 1991 Oct;48(4):256-60. Unique Identifier : AIDSLINE MED/92243991; Rodriguez MA; Runganga J; Contreras M; Ahya R; Howell DR; Barbara JA; Haematology Dept, Naval Hospital, Vina del Mar, Chile.; Modification of a commercial gelatin particle agglutination assay for anti-HIV-1 (MAT) has increased sensitivity, reduced reaction time and lowered the cost by 90%. We tested over 10,000 blood donations in parallel with the ELISA currently in use, and found the modified test to be highly sensitive and to enhance cost-
[Cases of acquired immunodeficiency syndrome (AIDS) in infancy]: Orv Hetil. 1991 Nov 17;132(46):2557-60. Unique Identifier : AIDSLINE MED/92244650; Marosvari I; Szekely E; Tabanyi R; Marialigeti T; Janos Korhaz-Rendelointezet, Gyermekosztaly.; The authors report about two cases of AIDS in infancy. Both infants were Rumanian citizen brought to Hungary for examinations. Hepatosplenomegaly, lymphadenopathy and recurrent upper respiratory tract infections respectively were th
Effect of human immunodeficiency virus type 1 protease on the intermediate filament subunit protein vimentin: cleavage, in vitro assembly and altered distribution of filaments in vivo following microinjection of protease.: Acta Histochem Suppl. 1991;41:129-41. Unique Identifier : AIDSLINE MED/92245043; Shoeman RL; Mothes E; Honer B; Kesselmeier C; Traub P; Max-Planck-Institut fur Zellbiologie, Ladenburg, Germany.; The intermediate filament (IF) subunit protein vimentin is efficiently cleaved in vitro by purified human immunodeficiency virus type 1 (HIV-1) protease. Immunological data confirm that identical sites are cleaved when vimentin is polymerized into filaments or occurs as protofilaments. Preformed filaments require 10 t
Koch's phenomenon: can it be corrected?: Tubercle. 1991 Dec;72(4):241-9. Unique Identifier : AIDSLINE MED/92245589; Stanford JL; Department of Medical Microbiology, University College and; Middlesex School of Medicine, London, UK.
Tuberculous splenic abscesses in patients with the acquired immune deficiency syndrome [letter]: Tubercle. 1991 Dec;72(4):307-8. Unique Identifier : AIDSLINE MED/92245604; Lozano F; Gomez-Mateos J; Lopez-Cortes L; Garcia-Bragado F
Recombinant alpha-2a interferon treatment in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC): clinical and immunological evaluation.: Allergol Immunopathol (Madr). 1991 Sep-Oct;19(5):201-7. Unique Identifier : AIDSLINE MED/92246027; Mezzaroma I; Avella A; Paganelli R; Ensoli B; d'Offizi G; Sirianni MC; Luzi G; Valdarchi C; Aiuti F; Department of Allergy & Clinical Immunology, University La; Sapienza, Rome, Italy.; We evaluated clinical efficacy and tolerability of recombinant alpha 2a interferon (IFN), in a group of 16 patients with AIDS and ARC, including 3 children. All patients were followed up monthly for clinical and immunological studies. The frequency of oportunistic infections (OI) in AIDS, and the following symptoms in
[Fatalities related to morphine and heroin administration]: Beitr Gerichtl Med. 1991;49:19-27. Unique Identifier : AIDSLINE MED/92246798; Wiese J; Klug E; Institut fur Rechtsmedizin, Freien Universitat Berlin.; Between 1978 and 1989 403 fatal cases (72% male; 28% female) due to morphine and/or heroin have been investigated in the Institute for Forensic Medicine of the Free University in Berlin (West). These are about 50% of all forensic drug-autopsies in Berlin (West). All cases, in which combinations of drugs and medicament
[The sociodemographic profile and physical growth patterns of pediatric patients with the acquired immunodeficiency syndrome followed at the San Juan City Hospital: 1986-1990]: Bol Asoc Med P R. 1991 Nov;83(11):479-84. Unique Identifier : AIDSLINE MED/92247166; Capriles Quiros JA; Conde JG; Gorrin JJ; Rios-Dones O; Departamento de Pediatria, Hospital Municipal de San Juan,; Puerto Rico.; Between September 1989 and August 1990, Puerto Rico was ranked third in the number of pediatric AIDS cases in the United States . The highest number of pediatric AIDS cases has been identified in high risk metropolitan areas. AIDS usually affects
The re-emergence of scrofula with HIV infection: a review of epidemiology, pathogenesis, diagnosis and treatment.: Bol Asoc Med P R. 1991 Nov;83(11):487-8. Unique Identifier : AIDSLINE MED/92247168; Deleyiannis FW; Ramirez Ronda CH; Yale University School of Medicine, New Haven, Connecticut.; Scrofula has been called The Dangerous Masquerader because of its propensity to mimic other diseases. Scrofula has been mistaken for metastatic carcinoma, regional neoplasms, thyroglossal duct cysts, fungal disease, toxoplasmosis, lymphoma, osteosarcoma, chondrosarcoma, bacterial adenitis, and collagen vascular diseas
[Experience with the use of immune intravenous immunoglobulin in symptomatic children with human immunodeficiency virus infection]: Bol Asoc Med P R. 1991 Dec;83(12):538-42. Unique Identifier : AIDSLINE MED/92247180; Jimenez E; Carrer MT; Perez Dieppa I; Ortiz L; Fernandez M; Departamento de Pediatria, Hospital Municipal de San Juan,; Puerto Rico.; The Department of Pediatrics of the San Juan City Hospital participated in a collaborative clinical trial, placebo controlled, designed by NICHD with the purpose of determining if the use of gamma immunoglobulin is effective in preventing serious infections in symptomatic children infected with HIV. Of the 372 childre
CNS involvement in AIDS patients as seen with CT and MR: a review.: Bol Asoc Med P R. 1991 Dec;83(12):548-51. Unique Identifier : AIDSLINE MED/92247183; Rodriguez WL; Ramirez-Ronda CH; Infectious Diseases Program, University of Puerto Rico School of; Medicine, San Juan.; The human immunodeficiency virus infected persons frequently have manifestations of central nervous system disfunction. These can be primary involvement or secondary processes such as infections or tumors. The present paper presents a short review of radiologic CNS findings in patients with AIDS as seen on CT and or M
Effects of aromatic polyamidines on the electrophoretic mobility of HIV-1 genomic regions amplified by polymerase-chain reaction.: Farmaco. 1991 Nov;46(11):1323-35. Unique Identifier : AIDSLINE MED/92247236; Feriotto G; Cortesi R; Nastruzzi C; Gambari R; Institute of Chemical Biology, University of Ferrara, Italy.; In this paper we describe the use of polymerase chain reaction (PCR) to amplify DNA sequences suitable for studies on the activity of DNA-binding drugs of possible interest in anti-tumor as well as anti-viral therapy. To this aim (a) we amplified by PCR two regions of the HIV-1 genome (one localized within the LTR, th
4-Diazo-5-alkylsulphonamidopyrazoles: synthesis and evaluation of biological activity.: Farmaco. 1991 Nov;46(11):1351-63. Unique Identifier : AIDSLINE MED/92247238; Vicentini CB; Veronese AC; Giori P; Pani A; Piras G; Gabrielsen A; La Colla P; Dipartimento di Scienze Farmaceutiche, Universita di Ferrara,; Italy.; A series of 4-diazo-5-alkylsulphonamidopyrazoles (5) was prepared and tested for antitumor, antiviral and antimicrobial activity. Compounds (5a) and (5b) showed a selective, although not very potent cytostatic activity against L1210 and a human T lymphoblastoid cell line (C8166). Compounds (5a) and (5d-h) showed a sel
[Research on the development of Chinese materia medica and natural drug for AIDS]: Chung Kuo Chung Yao Tsa Chih. 1991 Dec;16(12):707-10, 761. Unique Identifier : AIDSLINE MED/92247333; Zhu Y; Shanghai Institute of Chinese Materia Medica.
The high sensitivity cognitive screen.: Int Psychogeriatr. 1991 Winter;3(2):273-88. Unique Identifier : AIDSLINE MED/92248070; Fogel BS; Department of Psychiatry and Human Behavior, Brown University,; Providence, Rhode Island.; Ceiling effects limit the utility of many established brief cognitive screening tests for detecting and measuring mild delirious states and prodromal disorders. The High Sensitivity Cognitive Screen (HSCS) (Faust & Fogel, 1989), a bedside test taking approximately 25 minutes to administer, may overcome this limitat
[Evaluation of screening reagents for detection of HIV-1 antibody]: Chung Hua Liu Hsing Ping Hsueh Tsa Chih. 1991 Dec;12(6):369-73. Unique Identifier : AIDSLINE MED/92248679; Wang Z; AIDS Research and Detection Center, Chinese Academy of Preventive; Medicine.; Evaluation of screening reagents including PA, ELISA (Wellcome), IE, QWB, and LA by using 134 sera from HIV-1 infected persons and 1468 sera from normal persons. Comparing of domestic reagent and rapid methods by using part of the sera, and evaluating pooling sera method. The results suggested that the quality of PA,
Psychosocial predictors of reported HIV-preventive behaviour change among adults in Bulawayo, Zimbabwe.: Cent Afr J Med. 1991 Jul;37(7):196-202. Unique Identifier : AIDSLINE MED/92248682; Wilson D; Dubley I; Msimanga S; Lavelle L; Psychology Department, University of Zimbabwe, Mount Pleasant,; Harare.; In order to reduce HIV transmission, improved understanding of factors that motivate safer sexual behaviour is needed. The Health Belief Model attempts to explain health-related behaviour, including HIV-preventive behaviour. The association of six elements of this model--AIDS knowledge, perceived susceptibility to HIV
Age-dependent symptoms in human immunodeficient virus infected children [letter] [published erratum appears in Cent Afr J Med 1992 Apr;38(4):173] [see comments]: Cent Afr J Med. 1991 Jul;37(7):225. Unique Identifier : AIDSLINE MED/92248689; Wolf BH
Communicating with patients about infection control.: Dent Econ. 1991 Oct;81(10):71-3. Unique Identifier : AIDSLINE MED/92249630; Spas A
A study on existing knowledge about AIDS among Naval personnel.: J Commun Dis. 1991 Sep;23(3):191-4. Unique Identifier : AIDSLINE MED/92251091; Thergaonkar WP; Tripathy GC; Aggarwal SK; Nagaraja T; Sharma D; JDMS(H), Naval headquarters, New Delhi.; In the present study 1123 Naval personnel posted in one of the Naval bases were interviewed to find out the existing level of knowledge regarding AIDS and its prevention. The personnel had reasonably fair idea about the disease, modes of transmission and its prevention. It was interesting to observe that personnel had
Antimalarial antibody in relation to seroreactivity for HIV infection in sera from blood donors.: J Commun Dis. 1991 Sep;23(3):195-8. Unique Identifier : AIDSLINE MED/92251092; Chattopadhya D; Kumari S; Chatterjee R; Verghese T; National Institute of Communicable Diseases, Delhi.; A total of 74 specimens from blood donors showing evidence of HIV infection comprising of 40 positive by both ELISA and Western Blot (true positive), 16 positive by ELISA but negative by Western Blot (false positive) and 18 specimens positive by ELISA but showing indeterminate bands in Western Blot were screened for a
Limited evidence of human immunodeficiency virus type 2 (HIV-2) infection in sera from blood donors showing positive ELISA but negative or indeterminate western blot reactivity for HIV-1 infection.: J Commun Dis. 1991 Sep;23(3):206-7. Unique Identifier : AIDSLINE MED/92251097; Chattopadhya D; Kumari S; Verghese T; AIDS Reference Laboratory, National Institute of Communicable; Diseases, Delhi, India.
AIDS/HIV risk assessment and risk reduction counseling in a school-based clinic.: J Sch Health. 1991 Dec;61(10):443-5. Unique Identifier : AIDSLINE MED/92252328; Naughton SS; Edwards LE; Reed N; Health Start, Inc., St. Paul, MN 55101.
Thiamine deficiency and Wernicke's encephalopathy in AIDS.: Metab Brain Dis. 1991 Dec;6(4):207-12. Unique Identifier : AIDSLINE MED/92252789; Butterworth RF; Gaudreau C; Vincelette J; Bourgault AM; Lamothe F; Nutini AM; Laboratory of Neurochemistry, Andre-Viallet Clinical Research; Center, Hopital Saint-Luc, University of Montreal, Quebec,; Canada.; Several neuropathological reports in the last 5 years have described brain lesions characteristic of Wernicke s Encephalopathy in patients with AIDS. Using the erythrocyte transketolase activation assay, we now report biochemical evidence of thiamine deficiency in 9/39 (23%) of patients with AIDS or AIDS-related compl
The p17 stretch at the N terminus of the HIV1-gag precursor and the intracellular part of HIV1-env gp41 have heptad repeat regions in their sequences that could bind to each other in a coiled coil [letter]: Protein Seq Data Anal. 1991 Dec;4(6):375-6. Unique Identifier : AIDSLINE MED/92253555; Wachinger G; Nitschko H; Wachinger M; von der Helm K
Homologies between mycoplasma adhesion peptide, CD4 and class II MHC proteins: a possible mechanism for HIV-mycoplasma synergism in AIDS.: Res Immunol. 1991 Sep;142(7):519-23. Unique Identifier : AIDSLINE MED/92253823; Root-Bernstein RS; Hobbs SH; Department of Physiology, Michigan State University, East Lansing; 48824.
[Human immunodeficiency virus infection in hemophiliacs: prevalence and current clinical situation]: Sangre (Barc). 1991 Dec;36(6):451-5. Unique Identifier : AIDSLINE MED/92254074; Lorenzo JI; Molina R; Arilla MJ; Dasi MA; Monteagudo E; Aznar JA; Unidad de Coagulopatias Congenitas de la Comunidad Valenciana,; Hospital La Fe.; The prevalence of HIV-antibody was studied in a cohort of 156 haemophiliacs controlled since before 1986. Ninety four patients (60%) were HIV-seropositive, and all of them had been previously treated with non-heated factor concentrates. Seroprevalence was 50% by 1983. Evidence for previous negative results was only av
Extrapulmonary tuberculosis--a simple diagnosis? A retrospective study at Dar es Salaam, Tanzania.: Trop Geogr Med. 1991 Oct;43(4):375-8. Unique Identifier : AIDSLINE MED/92254251; Richter C; Ndosi B; Mwammy AS; Mbwambo RK; Department of Medicine, Muhimbili Medical Centre, Dar es Salaam,; Tanzania.; Data from the national tuberculosis programme show that extrapulmonary tuberculosis is increasing rapidly in Tanzania , most likely caused by the human immunodeficiency virus (HIV) epidemic. Retrospective data from 271 patients admitted to Muhimbili Medical Centre (MMC), Dar es Sa
Intravenous immune globulin use in patients with human immunodeficiency virus-related thrombocytopenia who require dental extraction.: West J Med. 1991 Dec;155(6):610-2. Unique Identifier : AIDSLINE MED/92254393; Rarick MU; Burian P; de Guzman N; Espina B; Montgomery T; Jamin D; Levine AM; Department of Internal Medicine, University of Southern; California School of Medicine, Los Angeles.; Five patients with human immunodeficiency virus (HIV)-related immune thrombocytopenia who were undergoing dental extraction were treated with intravenous immune globulin (IVIG). All patients received IVIG, 1 gram per kg, the day before the dental extraction and again the day of the dental extraction. Four patients had
[HIV-positive pregnancy. Good care is necessary]: Vardfacket. 1991 Sep 26;15(16):XV-XVII. Unique Identifier : AIDSLINE MED/92254453; Ottenblad C
Human immunodeficiency virus proteinase: now, then, what's next?: Adv Exp Med Biol. 1991;306:395-405. Unique Identifier : AIDSLINE MED/92254727; Graves MC; Department of Molecular Genetics, Roche Research Center,; Hoffman-La Roche Inc., Nutley, New Jersey 07110.
Substrate specificity of the human (type 1) and simian immunodeficiency virus proteases.: Adv Exp Med Biol. 1991;306:407-15. Unique Identifier : AIDSLINE MED/92254728; Debouck C; Department of Molecular Genetics, SmithKline Beecham; Pharmaceuticals, King of Prussia, Pennsylvania.
Expression and characterization of genetically linked homo- and hetero-dimers of HIV proteinase.: Adv Exp Med Biol. 1991;306:417-28. Unique Identifier : AIDSLINE MED/92254729; Krausslich HG; Traenckner AM; Rippmann F; Institut fur Virusforschung/ATV, Deutsches; Krebsforschungszentrum, Heidelberg.
Expression of the HIV aspartic protease fused to a bacterial phenotypic marker.: Adv Exp Med Biol. 1991;306:429-32. Unique Identifier : AIDSLINE MED/92254730; Korant BD; Rizzo CJ; Central Research & Development Department, Du Pont Experimental; Station, Wilmington, Delaware 19880-0328.
Comparison of three inhibitor complexes of human immunodeficiency virus protease.: Adv Exp Med Biol. 1991;306:433-41. Unique Identifier : AIDSLINE MED/92254731; Swain AL; Gustchina A; Wlodawer A; Macromolecular Structure Laboratory, NCI-Frederick Cancer; Research and Development Center, Maryland 21702-1201.
The three-dimensional x-ray crystal structure of HIV-1 protease complexed with a hydroxyethylene inhibitor.: Adv Exp Med Biol. 1991;306:455-60. Unique Identifier : AIDSLINE MED/92254733; Graves BJ; Hatada MH; Miller JK; Graves MC; Roy S; Cook CM; Krohn A; Martin JA; Roberts NA; Roche Research Center, Hoffmann-La Roche Inc., Nutley, New Jersey; 07110.
Substrate cleavage by HIV-1 proteinase.: Adv Exp Med Biol. 1991;306:461-7. Unique Identifier : AIDSLINE MED/92254734; Jupp RA; Richards AD; Phylip LH; Kay J; Konvalinka J; Strop P; Kostka V; Scarborough PE; Farmerie WG; Dunn BM; Department of Biochemistry, University of Wales College of; Cardiff, United Kingdom.
The evaluation of non-viral substrates of the HIV protease as leads in the design of inhibitors for AIDS therapy.: Adv Exp Med Biol. 1991;306:469-82. Unique Identifier : AIDSLINE MED/92254735; Tomasselli AG; Hui JO; Sawyer TK; Thaisrivongs S; Hester JB; Heinrikson RL; Upjohn Laboratories, Upjohn Company, Kalamazoo, Michigan 49001.; Scheme 1 summarizes some of what we have learned from this study of non-viral protein substrates of the HIV proteases. Many of these findings contradict the current understanding of protease specificity. P1-P1 amino acids need not be bulky or hydrophobic and residues at these positions may be even less important than
Interaction of mutant forms of the HIV-1 protease with substrate and inhibitors.: Adv Exp Med Biol. 1991;306:483-7. Unique Identifier : AIDSLINE MED/92254737; Darke PL; Kohl NE; Hanobik MG; Leu CT; Vacca JP; Guare JP; Heimbach JC; Dixon RA; Merck Sharp and Dohme Research Laboratories, West Point,; Pennsylvania 19486.
Structure-based inhibition of HIV-1 protease activity and viral infectivity.: Adv Exp Med Biol. 1991;306:489-92. Unique Identifier : AIDSLINE MED/92254738; DeCamp DL; Babe LM; Furth P; Ortiz de Montellano P; Kuntz ID; Craik CS; Department of Pharmaceutical Chemistry, University of California,; San Francisco 94143-0446.
Analysis of temperature-sensitive mutants of the HIV-1 protease.: Adv Exp Med Biol. 1991;306:493-7. Unique Identifier : AIDSLINE MED/92254739; Manchester M; Loeb DD; Everitt L; Moody M; Hutchison CA 3d; Swanstrom R; Department of Biochemistry, University of North Carolina, Chapel; Hill 27599.
Studies of the autoprocessing of the HIV-1 protease using cleavage site mutants.: Adv Exp Med Biol. 1991;306:499-502. Unique Identifier : AIDSLINE MED/92254740; Louis JM; Oroszlan S; Mora PT; Laboratory of Cellular and Developmental Biology, NIDDK, NIH,; Bethesda, Maryland 20892.
Monoclonal and polyclonal antibodies: reagents for studying HIV-1 proteinase variants.: Adv Exp Med Biol. 1991;306:507-10. Unique Identifier : AIDSLINE MED/92254742; Stoller TJ; Lim JJ; Woltizky BA; Graves MC; Department of Molecular Genetics, Roche Research Center,; Hoffmann-LaRoche, Inc., Nutley, New Jersey 07110.
Protein-engineered proteinase of myeloblastosis associated virus, an enzyme of high activity and HIV-1 proteinase-like specificity.: Adv Exp Med Biol. 1991;306:515-8. Unique Identifier : AIDSLINE MED/92254744; Strop P; Horejsi M; Konvalinka J; Skrabana R; Velek J; Blaha I; Cerna V; Pichova I; Pavlickova L; Andreansky M; et al; Institute of Organic Chemistry and Biochemistry, Czechoslovak; Academy of Sciences, Prague.
Scintillation proximity enzyme assay. A rapid and novel assay technique applied to HIV proteinase.: Adv Exp Med Biol. 1991;306:525-8. Unique Identifier : AIDSLINE MED/92254746; Cook ND; Jessop RA; Robinson PS; Richards AD; Kay J; Assay Development Group, Amersham International plc, Cardiff,; Wales, United Kingdom.
Cleavage of the intermediate filament subunit protein vimentin by HIV-1 protease: utilization of a novel cleavage site and identification of higher order polymers of pepstatin A.: Adv Exp Med Biol. 1991;306:533-7. Unique Identifier : AIDSLINE MED/92254748; Shoeman RL; Honer B; Stoller TJ; Mothes E; Kesselmeier C; Traub P; Graves MC; Max-Planck-Institut fur Zellbiologie, Ladenburg/Heidelberg,; Federal Republic of Germany.
A new type of aspartic proteinase inhibitors with a symmetric structure.: Adv Exp Med Biol. 1991;306:539-42. Unique Identifier : AIDSLINE MED/92254749; Tarasova NI; Gulnik SV; Prischenko AA; Livantsov MV; Lysogorskaya EN; Oksenoit ES; Moscow State University, Department of Chemistry, USSR.
Time dependent heterodimer formation leads to inhibition of HIV protease activity.: Adv Exp Med Biol. 1991;306:543-7. Unique Identifier : AIDSLINE MED/92254750; Babe LM; Craik CS; Department of Pharmaceutical Chemistry, University of California,; San Francisco 94143-0446.
Molecular modeling of the HIV-2 protease.: Adv Exp Med Biol. 1991;306:549-53. Unique Identifier : AIDSLINE MED/92254751; Gustchina A; Weber IT; Wlodawer A; Crystallography Laboratory, NCI-Frederick Cancer Research and; Development Center, Maryland 21702-1201.
AIDS drugs & the pharmaceutical industry: a need for reform.: Am J Law Med. 1991;17(4):363-410. Unique Identifier : AIDSLINE MED/92254822; Griffin MT; Temple University School of Law.; The pharmaceutical industry has long enjoyed substantial profits despite increased requirements for drug approval and various attempts to regulate the industry. Drug companies have avoided effective regulation by blaming high prices on the costs of research and development. The search for drugs effective in combatting
District Court of Puerto Rico--AIDS: military dismissal based on HIV status--Doe v. Rice.: Am J Law Med. 1991;17(4):462-3. Unique Identifier : AIDSLINE MED/92254825
Pennsylvania Superior Court--AIDS: disclosure of physician's HIV status--in re Milton S. Hershey Medical Center.: Am J Law Med. 1991;17(4):472-3. Unique Identifier : AIDSLINE MED/92254826
Human immunodeficiency virus type 2 (HIV-2) gene expression: downmodulation by sequence elements downstream of the transcriptional initiation site.: AIDS Res Hum Retroviruses. 1991 Dec;7(12):1007-14. Unique Identifier : AIDSLINE MED/92256040; Arya SK; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892.; Human immunodeficiency virus type 2 (HIV-2) gene expression is downmodulated by sequence elements downstream of the transcriptional initiation site, corresponding to the U5 region of the long terminal repeat (LTR) and further downstream. This repression appeared to be related more to the length of the sequence interve
The HIV-1 nef protein does not have guanine nucleotide binding, GTPase, or autophosphorylating activities.: AIDS Res Hum Retroviruses. 1991 Dec;7(12):1015-20. Unique Identifier : AIDSLINE MED/92256041; Backer JM; Mendola CE; Fairhurst JL; Kovesdi I; Molecular Biology Research Section, American Cyanamid Company,; Lederle Laboratories, Pearl River, NY 10965.; Recombinant HIV-1 Nef proteins with either thr-15 or ala-15 have been constructed and expressed in the T7 bacterial system. From the soluble portion of bacterial lysates both Nef(thr-15) and Nef(ala-15) have been purified to near homogeneity through 6 nondenaturing chromatographic steps in the presence of MgCl2. Neith
TIBO R82913, a new HIV-1 inhibiting agent, does not inhibit hematopoietic progenitor cells.: AIDS Res Hum Retroviruses. 1991 Dec;7(12):1021-3. Unique Identifier : AIDSLINE MED/92256042; Geissler RG; Ganser A; Ottmann OG; Kojouharoff G; Reutzel P; Andries K; Schellekens K; Hoelzer D; University of Frankfurt, Department of Hematology, Federal; Republic of Germany.; In progressive stages of infection with human immunodeficiency virus type 1 (HIV-1), the majority of patients develop a pathophysiologically not yet completely explainable bone marrow failure with anemia, leukopenia, and thrombocytopenia. The clinically most widely used HIV-inhibiting antiviral drugs azidothymidine (
Tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM): treatment with an anabolic steroid danazol.: AIDS Res Hum Retroviruses. 1991 Dec;7(12):1031-4. Unique Identifier : AIDSLINE MED/92256044; Harrington WJ Jr; Sheremata WA; Snodgrass SR; Emerson S; Phillips S; Berger JR; William J. Harrington Center for Blood Diseases, Department of; Medicine, University of Miami, FL 33136.; Tropical spastic paraparesis or HTLV-I-associated myelopathy is a progressive spastic disorder associated with the human T-lymphotropic virus type I. Some cases have responded to prednisone. Danazol is an attenuated androgen with minimal virilizing effects. It is used in the treatment of endometriosis and various auto
Role of viral strains and host genes in determining levels of immune complexes in a model system: implications for HIV infection.: AIDS Res Hum Retroviruses. 1991 Dec;7(12):963-9. Unique Identifier : AIDSLINE MED/92256045; Tishon A; Salmi A; Ahmed R; Oldstone MB; Department of Neuropharmacology, Scripps Research Institute, La; Jolla, CA.; Virus-antibody immune complexes form during infection with most RNA and DNA viruses, including those with human immunodeficiency virus (HIV). Yet a subset of individuals so infected apparently does not mount such responses. To understand the principles involved, we studied the formation and deposition of virus-antibod
Prevention of HIV infection by passive immunization with HIV immunoglobulin.: AIDS Res Hum Retroviruses. 1991 Dec;7(12):971-3. Unique Identifier : AIDSLINE MED/92256046; Prince AM; Reesink H; Pascual D; Horowitz B; Hewlett I; Murthy KK; Cobb KE; Eichberg JW; Lindsley F. Kimball Research Institute, New York Blood Center, NY; 10021.; The use of a human immunodeficiency virus (HIV) immune globulin (HIVIG) in prevention of HIV infection in chimpanzees was investigated in the hope of ultimate application to interruption of vertical transmission. In previous experiments, no protection was observed when relatively high challenge doses were used. This s
Analysis of the V3 loop in neutralization-resistant human immunodeficiency virus type 1 variants by direct solid-phase DNA sequencing.: AIDS Res Hum Retroviruses. 1991 Dec;7(12):983-90. Unique Identifier : AIDSLINE MED/92256048; Wahlberg J; Albert J; Lundeberg J; Von Gegerfelt A; Broliden K; Utter G; Fenyo EM; Uhlen M; Department of Biochemistry and Biotechnology, Royal Institute of; Technology, Stockholm, Sweden.; To study the molecular basis for the emergence of human immunodeficiency virus type 1 (HIV-1) variants with reduced sensitivity to neutralization by autologous sera, the DNA sequence of the envelope V3 loop was determined in HIV-1 isolates derived from four patients with primary HIV-1 infection and sequentially therea
Education of one's own patients an important basic step.: Todays FDA. 1991 Oct;3(10):5B. Unique Identifier : AIDSLINE MED/92256077; Greene Q
Inhibition of HIV replication by baicalin and S. baicalensis extracts in H9 cell culture.: Chin Med Sci J. 1991 Dec;6(4):230-2. Unique Identifier : AIDSLINE MED/92256931; Zhang X; Tang X; Chen H; Institute of Medical Biotechnology, CAMS, Beijing.; Crude extracts of Scutellia baicalensis and a particular low molecular weight substance known as Baicalin were shown to inhibit HIV antigen expression in H9 cell culture, with 50% inhibitory doses of 0.6 microgram/ml and 3.3 micrograms/ml, respectively. They also inhibited P24 antigen production in H9 cells, with IC50
Seroprevalence of HIV infection amongst antenatal women in greater Harare, Zimbabwe.: Cent Afr J Med. 1991 Oct;37(10):322-5. Unique Identifier : AIDSLINE MED/92257571; Mahomed K; Kasule J; Makuyana D; Moyo S; Mbidzo M; Tswana S; Department of Obstetrics and Microbiology, University of; Zimbabwe, Avondale, Harare.; Prevalence of HIV infection appears to be rising in many African countries. HIV infection in the pregnant woman poses a dilemma for the mother as well as for her unborn child. There are no data on HIV prevalence in Zimbabwe . This prospective study designed to determine HIV preval
Recognition of HIV/AIDS-associated oral lesions by the dental team.: Clin Prev Dent. 1991 Nov-Dec;13(6):5-11. Unique Identifier : AIDSLINE MED/92257843; Tilliss TS; Stach DJ; Department of Dental Hygiene, School of Dentistry, University of; Colorado, Denver.; The abilities of dentists, dental hygienists and dental assistants to recognize HIV/AIDS-associated intraoral lesions were examined and compared. Subjects who were attending a regional dental meeting were shown six color photographs (2.5 in x 3.5 in) and asked to determine what condition might be depicted. There were
[T-lymphocyte subsets of peripheral blood monocytes and their ability to form T-cell colony in breast tumor]: Chung Hua Wai Ko Tsa Chih. 1991 Sep;29(9):558-60, 589. Unique Identifier : AIDSLINE MED/92258240; Zhang LH; Second Affiliated Hospital, Hunan Medical University, Changsha.; T-lymphocyte subsets and their ability to form T-lymphocyte colony were studied in 29 patients with breast cancer, 13 patients with benign breast diseases, and 28 normal females. Cellular immunity was found suppressed in breast cancer patients with an abnormally elevated percentage of OKT8. There were a reversed ratio
Some ocular manifestations of systemic drug abuse.: J Am Optom Assoc. 1991 Nov;62(11):832-42. Unique Identifier : AIDSLINE MED/92259819; Urey JC; EYEXAM2000 of California, San Diego 92108.; Optometrists are increasingly likely to see patients who use illicit drugs, which may cause ocular signs which mimic other problems. This paper reviews pharmacologic effects on the eye of depressants, hallucinogens, inhalants, marijuana, opiates, and stimulants including amphetamines and cocaine. Drug abusers suffer f
Salmonella and Shigella gastroenteritis at a public teaching hospital in Nairobi, Kenya [see comments]: Infect Control Hosp Epidemiol. 1991 Dec;12(12):710-7. Unique Identifier : AIDSLINE MED/92259950; Paton S; Nicolle L; Mwongera M; Kabiru P; Mirza N; Plummer F; Wamola I; Department of Medical Microbiology, University of Manitoba,; Winnepeg, Canada.; OBJECTIVE: To measure the proportion of nosocomial diarrhea cases associated with Salmonella and Shigella species. DESIGN: Prospective 6-month survey. SETTING: Tertiary care center in a developing country. PATIENTS: Pediatric and adult patients admitted with the previous 24 hours and all consenting adult or pediatric
Collaborative education regarding prevention of human immunodeficiency virus transmission in healthcare settings--Ghana.: Infect Control Hosp Epidemiol. 1991 Dec;12(12):718-24. Unique Identifier : AIDSLINE MED/92259951; Cronin W; Antwi P; Larson E; Johnson and Johnson Medical Inc., Arlington, Texas.; OBJECTIVE: To evaluate the effectiveness of a collaborative and participatory approach to professional training to reduce the risk of human immunodeficiency virus (HIV) transmission. SETTING: Healthcare settings in Ghana . METHODS: Two 5-day workshops were conducted for high-level nu
Decoy may block key AIDS protein [news]: Infect Control Hosp Epidemiol. 1991 Dec;12(12):744. Unique Identifier : AIDSLINE MED/92259955
Prevalence of positive anti-HIV in pregnant women at Ramathibodi Hospital.: J Med Assoc Thai. 1991 Dec;74(12):653-7. Unique Identifier : AIDSLINE MED/92260125; Jirapinyo M; Petchclai B; Phiromsawat S; Department of Obstetrics & Gynaecology, Faculty of Medicine,; Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.; Anti-HIV screening has routinely been done at the antenatal clinic in Ramathibodi Hospital since January 1990. The prevalence of positive anti-HIV during the first and second half of 1990, and the first half of 1991 are 0.056, 0.2, 0.24 per cent respectively. Twenty positive cases are now under counselling. Age range
Mandatory HIV testing legislation introduced. An interview with Rep. Dave Jaye.: J Mich Dent Assoc. 1991 Sep;73(7):18-20. Unique Identifier : AIDSLINE MED/92260501; Jaye D
AIDS: fear and fact.: J Mich Dent Assoc. 1991 Sep;73(7):27-9. Unique Identifier : AIDSLINE MED/92260503; Herschfus L; Department of Dental Surgery and Oral Medicine, Grace Hospital,; Detroit.
Sexual abstinence in patients with HIV infection: a 2-year follow-up study.: J Natl Med Assoc. 1991 Dec;83(12):1102-3. Unique Identifier : AIDSLINE MED/92260560; Jordan WC; Office of Postgraduate Medical Education, Martin Luther King Jr; General Hospital, Los Angeles, CA 90059.; Thirty-five human immunodeficiency virus (HIV)-positive patients were followed over a 2-year period. All agreed to abstain from sexual intercourse. This group had a low level of recurring infections. A comparison study of sexually active HIV males is underway.
The simian immunodeficiency viruses.: Mol Aspects Med. 1991;12(4):247-53. Unique Identifier : AIDSLINE MED/92261266; McClure MO; Department of Communicable Diseases, St. Mary's Hospital,; Paddington, London, U.K.
HIV and tropism: implications for pathogenesis.: Mol Aspects Med. 1991;12(4):267-82. Unique Identifier : AIDSLINE MED/92261268; Dalgleish AG; Habeshaw J; Manca F; Department of Oncology, St. George's Hospital, Tooting, London,; U.K.
Proteinase inhibitors.: Mol Aspects Med. 1991;12(4):329-40. Unique Identifier : AIDSLINE MED/92261272; Baboonian C; Dalgleish AG; Clinical Research Centre, Harrow, Middlesex, U.K.
AIDS and dentistry. Meeting the challenge of HIV infection.: Ont Dent. 1991 Sep;68(7):20-2. Unique Identifier : AIDSLINE MED/92262072; Hurst D
Cytokines and HIV infection: is AIDS a tumor necrosis factor disease? [editorial]: AIDS. 1991 Dec;5(12):1405-17. Unique Identifier : AIDSLINE MED/92265222; Matsuyama T; Kobayashi N; Yamamoto N
Virological markers in the cerebrospinal fluid from HIV-1-infected individuals.: AIDS. 1991 Dec;5(12):1419-24. Unique Identifier : AIDSLINE MED/92265223; Buffet R; Agut H; Chieze F; Katlama C; Bolgert F; Devillechabrolle A; Diquet B; Schuller E; Pierrot-Deseilligny C; Gentilini M; et al; Laboratoire de Bacteriologie-Virologie, Hopital de la; Pitie-Salpetriere, Paris, France.; We analysed 127 specimens of cerebrospinal fluid (CSF) from 118 HIV-1-infected individuals at different stages of infection. Intrathecal antibody synthesis was evident in 23 samples tested and was more frequently directed against HIV than against rubella virus, herpes simplex virus, varicella zoster virus or
Rheumatoid factors and circulating immune complexes in HIV-infected individuals.: AIDS. 1991 Dec;5(12):1441-6. Unique Identifier : AIDSLINE MED/92265226; Procaccia S; Blasio R; Villa P; Lazzarin A; Bonacina C; Novati R; Bini T; Memoli M; Imondi N; Zanussi C; Istituto di Medicina Interna, University of Milan, Italy.; We studied serological aspects of autoimmunity in patients with AIDS, AIDS-related complex (ARC) and in individuals at risk for AIDS. Immunoglobulin (Ig) M, IgG and IgA rheumatoid factors (RF) were quantified by enzyme-linked immunosorbent assay (ELISA), Ig by radial immunodiffusion, and circulating immune complexes (
Non-isotopic polymerase chain reaction methods for the detection of HIV-1 in Ugandan mothers and infants.: AIDS. 1991 Dec;5(12):1463-7. Unique Identifier : AIDSLINE MED/92265229; Jackson JB; Ndugwa C; Mmiro F; Kataaha P; Guay L; Dragon EA; Goldfarb J; Olness K; Department of Pathology, Case Western Reserve University,; Cleveland, Ohio 44106.; Two non-isotopic polymerase chain reaction (PCR) methods were evaluated by testing blood from 41 HIV-1-seropositive and 16 HIV-1-seronegative Ugandan mothers and 56 of their children (aged 0.5-15.0 months). Amplification of HIV-1 sequences was performed in duplicate using a biotinylated primer pair to the gag region (
Propagation and properties of Kaposi's sarcoma-derived cell lines obtained from patients with AIDS: similarity of cultured cells to smooth muscle cells.: AIDS. 1991 Dec;5(12):1485-93. Unique Identifier : AIDSLINE MED/92265232; Wittek AE; Mitchell CD; Armstrong GR; Albini A; Martin GR; Seemann R; Levenbook IS; Wierenga DE; Ridge J; Dunlap RC; et al; Division of Virology, Food and Drug Administration, National; Institutes of Health, Bethesda, Maryland.; Cells derived from Kaposi s sarcoma (KS) were propagated in vitro using conditions which resulted in elimination of contaminating fibroblasts and the emergence of homogeneous cell populations which morphologically resembled smooth muscle cells and had neoplastic characteristics. In long-term culture, they differentiat
Efficacy of octreotide in the management of chronic diarrhoea in AIDS.: AIDS. 1991 Dec;5(12):1495-9. Unique Identifier : AIDSLINE MED/92265233; Romeu J; Miro JM; Sirera G; Mallolas J; Arnal J; Valls ME; Tortosa F; Clotet B; Foz M; Infectious Diseases Unit, Hospital de Badalona, Barcelona, Spain.; Patients with HIV infection were studied to assess the efficacy of octreotide, a somatostatin analogue, in the long-term management of refractory diarrhoea. Dosage of subcutaneous octreotide was increased progressively at 48 h intervals from 150 to 300, 750 and 1500 micrograms/day according to response. Twenty-nine pa
Cognitive impairment in HIV infection.: AIDS. 1991 Dec;5(12):1501-7. Unique Identifier : AIDSLINE MED/92265234; Krikorian R; Wrobel AJ; Department of Psychiatry, University of Cincinnati Medical; Center, Ohio.; HIV-infected subjects at various stages of illness but without opportunistic cerebral disease were evaluated using a comprehensive, cognitively-based neuropsychological protocol and measures of levels of depression and anxiety. The data indicated a prominent attentional disorder among impaired subjects; however, langu
Risk factors and HIV seropositivity among injecting drug users in Bangkok.: AIDS. 1991 Dec;5(12):1509-13. Unique Identifier : AIDSLINE MED/92265235; Choopanya K; Vanichseni S; Des Jarlais DC; Plangsringarm K; Sonchai W; Carballo M; Friedmann P; Friedman SR; Health Department Bangkok Metropolitan Administration (BMA),; Thailand.; Bangkok experienced an extremely rapid spread of HIV infection among drug injectors in 1987 and 1988. This study examines risk factors for HIV infection and deliberate risk-reduction efforts by drug injectors. Two subsamples of injecting drug users were recruited in November 1989, a group in drug-use treatment (n = 34
Research into HIV and AIDS between 1981 and 1990: the epidemic curve.: AIDS. 1991 Dec;5(12):1515-9. Unique Identifier : AIDSLINE MED/92265236; Elford J; Bor R; Summers P; Department of Public Health and Primary Care, Royal Free Hospital; School of Medicine, London, UK.; The main features of research into HIV and AIDS between 1981 and 1990 were examined using a database of medical, nursing and dental journals [compact disc read-only memory (CD-ROM) version of the Medline database (Silver Platter Information Services, London, UK)]. More than 30,000 papers on HIV and AIDS were indexed b
Fertility rates in 238 HIV-1-seropositive women in Zaire followed for 3 years post-partum.: AIDS. 1991 Dec;5(12):1521-7. Unique Identifier : AIDSLINE MED/92265237; Ryder RW; Batter VL; Nsuami M; Badi N; Mundele L; Matela B; Utshudi M; Heyward WL; Project Sida, Kinshasa, Zaire.; Birth-control use and fertility rates were prospectively determined in 238 HIV-1-seropositive and 315 HIV-1-seronegative women in Kinshasa, Zaire , during the 36-month period following the delivery of their last live-born child. No women delivered children during the first follow-u
Trends in HIV-1 and HIV-2 infection in The Gambia [letter]: AIDS. 1991 Dec;5(12):1529-30. Unique Identifier : AIDSLINE MED/92265239; Wilkins A; Oelman B; Pepin J; Cham K; Corrah T; Hughes A; Manneh K; Manneh K; Njai R; Rolfe M; et al
Detection of HIV-1 genome in lymph-node biopsies by polymerase chain reaction: a useful tool for epidemiological studies [letter]: AIDS. 1991 Dec;5(12):1531-2. Unique Identifier : AIDSLINE MED/92265240; Uccini S; Paradiso P; De Re V; Boiocchi M; Luzi G; Fantini B; Ruco LP; Baroni CD
Residual blood in syringes: size and type of syringe are important [letter]: AIDS. 1991 Dec;5(12):1532-3. Unique Identifier : AIDSLINE MED/92265241; Grund JP; Stern LS
Simple phospholipids have selective anti-HIV activity [letter]: AIDS. 1991 Dec;5(12):1536-7. Unique Identifier : AIDSLINE MED/92265243; McGuigan C; O'Connor TJ; Swords B; Kinchington D
Giant esophageal aphthous ulcers in AIDS patients: treatment with low-dose corticosteroids [letter]: AIDS. 1991 Dec;5(12):1537-8. Unique Identifier : AIDSLINE MED/92265244; Sokol-Anderson ML; Prelutsky DJ; Westblom TU
Hyposplenism in AIDS [letter]: AIDS. 1991 Dec;5(12):1538-40. Unique Identifier : AIDSLINE MED/92265245; Grotto HZ; Costa FF
Immunoregulatory factors contributing to fetal allograft survival.: Int J Dev Biol. 1991 Sep;35(3):275-8. Unique Identifier : AIDSLINE MED/92265569; Rukavina D; Kapovic M; Radojcic A; Department of Physiology and Immunology, University of Rijeka,; Medical Faculty, Republic of Croatia, Yugoslavia.; A mammalian fetus expresses a variety of antigens potentially unknown to the immunologically competent mother. Presented here are the results of investigations of maternal immune reactivity to paternally derived antigens of fetoplacental unit, detected at various levels: 1) spleen and distant lymphatic organs, 2) regi
[Quantitative and qualitative changes in the immunoglobulins of HIV-infected children]: Rev Roum Virol. 1991 Jul-Dec;42(3-4):123-33. Unique Identifier : AIDSLINE MED/92265631; Alexandrescu R; Ditu S; Gaucan E; Cernescu C; Institut de Virologie Stefan S. Nicolau, Bucarest, Roumanie.; In HIV-infected children impairment of B lymphocytes appears to precede the T cell deficiency, elevated but dysfunctional immunoglobulins being a hallmark of pediatric infection. Electrophoretic and immunochemical data obtained with samples from 91 cases of AIDS in children aged 7-36 months in P2 clinical stage are re
[The AIDS epidemic among children in Romania. The current data and short-term forecasts]: Rev Roum Virol. 1991 Jul-Dec;42(3-4):157-69. Unique Identifier : AIDSLINE MED/92265635; Cajal N; Cernescu C; Institut de Virologie Stefan S. Nicolau, Bucarest, Roumanie.; Situation and main characteristics of the AIDS epidemics in Romania are analysed. Prevention measures, among which it is worth mentioning a correct information of the population, are proposed.
[The knowledge and attitudes of medical students in their 2d year about AIDS]: Rev Roum Virol. 1991 Jul-Dec;42(3-4):177-89. Unique Identifier : AIDSLINE MED/92265637; Deutsch I; Blujdescu M; Cernescu C; Institut de Virologie Stefan S. Nicolau, Bucarest, Roumanie.; This study had two specific aims: determining the level of knowledge about AIDS acquired through the courses on this subject; analysing the students attitude towards the disease, with respect to different aspects related to the future professional risk. For this purpose, a questionnaire was made up and from the answe
AIDS and Sjogren's syndrome.: Bull Rheum Dis. 1991;40(6):6-8. Unique Identifier : AIDSLINE MED/92266160; Talal N; HIV infection can produce a clinical syndrome and immunologic changes similar to those seen in SS. HIV infection can occasionally result in an SS-like disease but without the formation of antibodies to Ro(SS-A) or La(SS-B). Could this mean that a retrovirus yet to be discovered is responsible for the autoimmune exocri
The combined treatment of human peripheral blood mononuclear cells with thymolymphotropin and interleukin 2 increases PPD-driven T-cell proliferation and IL-2 induced cellular cytotoxicity against HIV-infected cells.: Int J Immunopharmacol. 1991;13(8):1157-65. Unique Identifier : AIDSLINE MED/92267736; Di Massimo AM; Gilardini MS; Bardone MR; Moras ML; Malkovsky M; Antonelli G; Colizzi V; Department of Biology, II University of Rome, Italy.; Two in vitro systems (the DNA synthetic response to mycobacterial antigens and cytotoxicity against lymphoid cells) were used to analyse the effect of thymolymphotropin (TLT) on peripheral blood mononuclear cells (PBMC). Purified protein derivative of mycobacteria (PPD)-driven T-cell proliferation in low-responder don
HIV testing [editorial]: J Ir Dent Assoc. 1991;37(2):37. Unique Identifier : AIDSLINE MED/92268690; Hayes NF
WHO sets guidelines for preventing HBV/HIV transmission in healthcare settings [news]: Philipp J Nurs. 1991 Jul-Dec;61(3-4):34-5. Unique Identifier : AIDSLINE MED/92270648
Statement of the ICN on the World Health Assembly technical discussions on strategies for Health for All in the face of rapid urbanization (May 1991).: Philipp J Nurs. 1991 Jul-Dec;61(3-4):4-5. Unique Identifier : AIDSLINE MED/92270651
Sharing the challenge World AIDS Day.: Philipp J Nurs. 1991 Jul-Dec;61(3-4):44-5. Unique Identifier : AIDSLINE MED/92270652
[Identification of isosporiasis in patients with acquired immunodeficiency syndrome in Salvador, Bahia]: Rev Soc Bras Med Trop. 1991 Jan-Mar;24(1):61-2. Unique Identifier : AIDSLINE MED/92270902; Moreira Junior ED; Silva N; Barberino MG; Brites C; Johnson Junior WD; Badaro R; Laboratorio de Retrovirus do Hospital Professor Edgar Santos,; Universidade Federal da Bahia, Salvador, Brasil.
[Mycoses and adrenocortical function. New pathogenetic aspects of adrenal hypofunction]: Recenti Prog Med. 1991 Dec;82(12):652-60. Unique Identifier : AIDSLINE MED/92270956; Angeli A; Masera RG; Gatti G; Dipartimento di Scienze cliniche e biologiche, Universita,; Torino.; Three aspects of the possible relationships between adrenocortical function and mycoses are considered: a) abnormal steroid hormone concentrations that may favour onset and/or clinical course of mycotic diseases; b) presence of granulomas in the adrenal glands during systemic mycoses; c) effects of antifungal drugs on
Effect of zidovudine on cerebrospinal fluid in patients with HIV infection and acute neurological disease.: Scand J Infect Dis. 1991;23(6):681-5. Unique Identifier : AIDSLINE MED/92271082; Hagberg L; Andersson M; Chiodi F; Fuchs D; Svennerholm B; Wachter H; Norkrans G; Department of Infectious Diseases, University of Goteborg, Ostra; Hospital, Sweden.; Two cases of HIV infection associated with neurological complications are described. The patients had been followed with repeated cerebrospinal fluid (CSF) analyses 1-3 years before the neurological disease and 5 months after zidovudine treatment. CSF mononuclear cell count and the AIDS predictors beta 2-microglobulin
Calprotectin in cerebrospinal fluid of the HIV infected: a diagnostic marker of opportunistic central nervous system infection?: Scand J Infect Dis. 1991;23(6):687-9. Unique Identifier : AIDSLINE MED/92271083; Dunlop O; Bruun JN; Myrvang B; Fagerhol MK; Department of Infectious Diseases, Ullevaal University Hospital,; Oslo, Norway.; The calprotectin level in the cerebrospinal fluid (CSF) of 15 HIV positive patients with symptoms from the central nervous system (CNS) was measured. All 5 patients with opportunistic infections had levels above the reference range and all 10 patients with HIV associated encephalopathy had levels within the reference
Dissemination of Pneumocystis carinii in patients with AIDS.: Scand J Infect Dis. 1991;23(6):691-5. Unique Identifier : AIDSLINE MED/92271084; Witt K; Nielsen TN; Junge J; Department of Infectious Disease, Hvidovre Hospital, University; of Copenhagen, Denmark.; Extrapulmonary Pneumocystis carinii infections in AIDS are still rare although the number of cases is increasing. We present 2 cases of extrapulmonary pneumocystosis detected at our institution during an 8-month period. The first was a patient treated for P. carinii pneumonia (PCP) disseminated to liver, spleen and ki
Low yield of screening for cryptococcal antigen by latex agglutination assay on serum and cerebrospinal fluid from Danish patients with AIDS or ARC.: Scand J Infect Dis. 1991;23(6):697-702. Unique Identifier : AIDSLINE MED/92271085; Hoffmann S; Stenderup J; Mathiesen LR; Department of Infectious Diseases, University of Copenhagen,; Hvidovre Hospital, Denmark.; From July 1, 1989 to September 5, 1990, 530 serum specimens and 50 cerebrospinal fluid (CSF) specimens from 334 HIV-1 infected patients, most of whom had AIDS or ARC, were analysed in a cryptococcal antigen latex agglutination assay, and all were negative. Three cases of meningitis due to Cryptococcus neoformans diagn
Cerebral toxoplasmosis in Danish AIDS patients.: Scand J Infect Dis. 1991;23(6):703-9. Unique Identifier : AIDSLINE MED/92271086; Smith E; Pers C; Aschow C; Mathiesen L; Department of Infectious Diseases, Hvidovre Hospital, University; of Copenhagen, Denmark.; We estimate the frequency of central nervous system (CNS) toxoplasmosis in Danish AIDS patients and evaluate the diagnostic accuracy using the following criteria for acceptance of the diagnosis: either (1) the demonstration of Toxoplasma gondii in brain tissue or (2) one or more hypodense or ring-enhancing lesions on
Natural killer cells and the post viral fatigue syndrome.: Scand J Infect Dis. 1991;23(6):711-6. Unique Identifier : AIDSLINE MED/92271087; Ho-Yen DO; Billington RW; Urquhart J; Microbiology Department, Raigmore Hospital, Inverness, United; Kingdom.; 60 patients were referred with a diagnosis of post viral fatigue syndrome (PVFS), but only 50 fulfilled strict criteria for this illness. Many lymphocyte subpopulations were normal, but there was a spectrum of natural killer (NK) cell results: 20/50 (40%) were raised; 8/50 (16%) were low;, 5/50 (10%) were low initiall
Design of site-specific protein drugs.: Sci Total Environ. 1991 Dec;109-110:9-16. Unique Identifier : AIDSLINE MED/92271182; Tomlinson E; Somatix Corporation, Cambridge, MA 02139.; The ability to clone and express proteins at high levels of abundance and purity has led to their increasing consideration as therapeutic agents. The use of various protein engineering and recombinant DNA techniques has enabled progression to where proteins can be tailored so that they have not only the ability to int
Physicians and the human immunodeficiency virus [editorial]: West J Med. 1991 Nov;155(5):540-1. Unique Identifier : AIDSLINE MED/92271503; Volbending PA
Human immunodeficiency virus infection in children who received transfusions in Mexico [letter]: West J Med. 1991 Nov;155(5):547. Unique Identifier : AIDSLINE MED/92271506; Ferdman RM; Church JA; Mascola L; Sato JK
Medication usage patterns in patients with human immunodeficiency virus infection: a comparison of patient-reported medication usage with medical chart review.: DICP. 1991 Dec;25(12):1374-8. Unique Identifier : AIDSLINE MED/92271570; Corelli RL; Guglielmo BJ; Kapusnik-Uner JE; McMaster JR; Greenblatt RM; Division of Clinical Pharmacy, School of Pharmacy, University of; California, San Francisco.; Patients infected with the human immunodeficiency virus (HIV) receive numerous medications from multiple providers. As a result, it is important that medication usage is properly documented in each patient s medical record. Lack of adequate documentation may confound a provider s assessment of drug efficacy, potential
Free-radical synthesis of 3-(2-cyanoethyl)- and 3-(2-methoxycarbonylethyl)-2,3-dideoxy-alpha-D-erythro-pentofu ranoside and their application in the synthesis of potential antiviral nucleosides.: Arch Pharm (Weinheim). 1991 Dec;324(12):953-8. Unique Identifier : AIDSLINE MED/92272586; Lau J; Walczak K; Pupek K; Buch C; Nielsen CM; Pedersen EB; Department of Chemistry, Odense University, Denmark.; Free-radical reaction of different carbohydrate educts 2, 5, and 7 with acrylonitrile in the presence of tributyltin hydride and a radical initiator (AIBN) gave the methyl 3-(2-cyanoethyl)-2,3-dideoxypentofuranosides 3a and 6. Similar reaction of 2 with methyl acrylate gave 3-(2-methoxycarbonylethyl)-2,3-dideoxypentof
Leukocyte immunophenotypes in bronchoalveolar lavage fluid and peripheral blood of paracoccidioidomycosis, sarcoidosis and silicosis.: Histol Histopathol. 1991 Jul;6(3):395-402. Unique Identifier : AIDSLINE MED/92240007; Tapia FJ; Goihman-Yahr M; Caceres-Dittmar G; Altieri E; Gross A; Isturiz G; Rosquete R; Viloria N; Avila-Millan E; Carrasquero M; et al; Biomedical Institute of Central University of Venezuela.; Leukocyte subsets in bronchoalveolar lavage (BAL) fluid and peripheral blood of patients with paraccoccidioidomycosis, sarcoidosis and silicosis were characterized using monoclonal antibodies and an immunoperoxidase technique. In paraccocidioidomycosis, the number of T-helper/inducer CD4-positive lymphocytes was lower
Patients with AIDS: do we have a duty to treat? Part 1.: Compendium. 1991 Sep;12(9):676, 678, 680. Unique Identifier : AIDSLINE MED/92240608; Koelbl JJ; Loyola University School of Dentistry, Maywood, Illinois.
Promising investigational drug available to AIDS patients.: Bol Asoc Med P R. 1991 Nov;83(11):508-9. Unique Identifier : AIDSLINE MED/92247175
Carbon dioxide laser surgery [letter; comment]: Spec Care Dentist. 1991 Sep-Oct;11(5):211-2. Unique Identifier : AIDSLINE MED/92254097; Salman RA; Department of Oral and Maxillofacial Surgery, New York; University.
Treatment modalities for intraoral Kaposi's sarcoma: report of case.: Spec Care Dentist. 1991 Nov-Dec;11(6):231-3. Unique Identifier : AIDSLINE MED/92263177; Chockley B; Coke JM; Saint Joseph Hospital, Denver 80218-1191.; Intraoral Kaposi s sarcoma (KS) is a lesion seen commonly in patients with AIDS. These lesions can interfere with both speech and mastication. The dental team should be aware of the various treatment modalities for KS and the complications associated with these treatments. One of the treatment modalities reviewed here
Correlation of plasma growth hormone level with wasting syndrome in feline AIDS [letter]: AIDS. 1991 Dec;5(12):1542-3. Unique Identifier : AIDSLINE MED/92265247; Teng CS
Mandatory HIV testing [editorial]: CDS Rev. 1991 Oct;84(9):12-3. Unique Identifier : AIDSLINE MED/92266403; Walsh T
Oral care of HIV infected patients: the knowledge and attitudes of Irish dentists.: J Ir Dent Assoc. 1991;37(2):41-3. Unique Identifier : AIDSLINE MED/92268692; McCartan BE; Samaranayake LP; Department of Oral Medicine and Pathology Trinity College,; Dublin.; As the numbers of people with HIV infection and AIDS increase, so will the contribution required from dental practitioners. A postal questionnaire survey was therefore conducted among dental practitioners in Ireland to determine the
[The ocular manifestations in the acquired immunodeficiency syndrome]: Oftalmologia. 1991 Apr-Jun;35(2):20-9. Unique Identifier : AIDSLINE MED/92247764; Nicu C; Sectia oftalmologie, Spitalul Judetean Drobeta, Turnu Severin.; The ocular manifestations in the infection with the human immunodeficiency virus are mentioned, among which the ischaemic retinal vasculopathy, the presence of dysoric nodules and the retinal vascularity. In addition, the presence of severe ocular manifestation caused by superinfections with
[First reported case of AIDS in China]: Chung Hua I Hsueh Tsa Chih (Taipei). 1991 Dec;71(12):671-3, 46. Unique Identifier : AIDSLINE MED/92248465; Wang N; In this paper is reported the first case of acquired immunodeficiency syndrome (AIDS) in the Chinese continent. In the initial stage, the patient (male) experienced fever, malaise and headache in April, 1990, and then developed repeated pulmonary infection and insidious progressive subacute encephalitis. The diagnosis
[A clinical study of 100 cases of AIDS in Africa]: Chung Hua I Hsueh Tsa Chih (Taipei). 1991 Dec;71(12):674-5, 46. Unique Identifier : AIDSLINE MED/92248466; Yu X; In this article, 100 cases of AIDS observed in Africa by the Chinese Medical Team are reported. The general clinical data were analyzed and studied, and the changes in the oral cavity and on the skin (Kaposi s sarcoma) are described. The results showed that oral mycotic infection and Kaposi s sarcoma are the strong ev
[Monitoring and controlling of renal transplant infection]: Chung Hua I Hsueh Tsa Chih (Taipei). 1991 Dec;71(12):676-9, 46. Unique Identifier : AIDSLINE MED/92248467; Fu W; Infection is still the leading cause of death in renal transplantation. How to control it is an urgent problem to be solved. Bacteria culture, computerized monitoring methods, OKT monoclonal antibody techniques and radioimmunoassay (RIA) were applied to study the cause, monitoring and prevention of the infection. The
Intraoral cytomegalovirus lesion and HIV-associated periodontitis in a patient with acquired immunodeficiency syndrome.: Oral Surg Oral Med Oral Pathol. 1991 Dec;72(6):716-20. Unique Identifier : AIDSLINE MED/92253198; Glick M; Cleveland DB; Salkin LM; Alfaro-Miranda M; Fielding AF; Department of Oral Medicine, School of Dentistry, Temple; University, Philadelphia, Pa.; Exposure to cytomegalovirus ( CMV ) is common in persons infected with the human immunodeficiency virus. Autopsy studies have documented the presence of CMV in multiple organs, but CMV is seldom indicated as the causative agent
Malignant lymphomas in Japanese AIDS patients.: Acta Pathol Jpn. 1991 Oct;41(10):744-50. Unique Identifier : AIDSLINE MED/92254624; Mori S; Koike M; Hondo R; Wakabayashi T; Maeda Y; Kazuyama Y; Kataoka I; Watanabe T; Department of Pathology, University of Tokyo, Japan.; Seven non-Hodgkin s malignant lymphomas (MLs) were found in 25 Japanese AIDS (acquired immune deficiency syndrome) patients who died at two hospitals in Tokyo. All of these MLs originated from extranodal organs including the brain (three cases), skin (two cases) liver and adrenal gland. B cell markers were demonstrate
Mutational analysis of a native substrate of the HIV-1 proteinase.: Adv Exp Med Biol. 1991;306:503-6. Unique Identifier : AIDSLINE MED/92254741; Partin K; Wimmer E; Carter C; Department of Microbiology, State University of New York, Stony; Brook 11794-8621.; The purpose of this study was to define further the determinants of substrate specificity of HIV-1 PR. Rather than using small peptides, we used an in vitro system which permitted us to evaluate the effect of a mutated site within the context of its natural precursor. We made single-amino-acid substitutions around two
Cloning, expression and kinetic characterization of the feline immunodeficiency virus proteinase.: Adv Exp Med Biol. 1991;306:511-3. Unique Identifier : AIDSLINE MED/92254743; Farmerie WG; Goodenow MM; Dunn BM; Department of Biochemistry and Molecular Biology, University of; Florida, Gainesville 32610.
Recent recommendations from the Centers for Disease Control.: Dent Today. 1991 Sep;10(7):29. Unique Identifier : AIDSLINE MED/92255894; Carpenter KL
Fighting for organized dentistry: an interview with incoming ADA President Geraldine T. Morrow, DMD [interview by Dr. Hugh F. Doherty CF: Dent Today. 1991 Sep;10(7):30, 32-3. Unique Identifier : AIDSLINE MED/92255895; Morrow GT
Formation of lentivirus particles by mammalian cells infected with recombinant fowlpox virus.: AIDS Res Hum Retroviruses. 1991 Dec;7(12):991-8. Unique Identifier : AIDSLINE MED/92256049; Jenkins S; Gritz L; Fedor CH; O'Neill EM; Cohen LK; Panicali DL; Therion Biologics Corporation, Cambridge, MA 02142.; Recombinant fowlpox viruses (FPV) containing the env or gag-pol genes of simian immunodeficiency virus from macaques (SIVmac) were constructed. The env, gag, and pol-encoded polypeptides were efficiently expressed and processed in avian cells productively infected with FPV as well as in mammalian cells, in which FPV i
Recommendations for preventing transmission of human immunodeficiency virus and hepatitis B virus to patients during exposure-prone invasive procedures.: J Mich Dent Assoc. 1991 Sep;73(7):22-4. Unique Identifier : AIDSLINE MED/92260502
The AIDS research agenda at the National Institutes of Health.: Am J Hosp Pharm. 1991 Dec;48(12):2662-6. Unique Identifier : AIDSLINE MED/92264418; Minor JR; Hamburg MA; Pharmacy Department, National Institutes of Health, Bethesda, MD; 20892.; The foundation, goals, and components of the research strategy developed by the National Institutes of Health to combat AIDS and HIV infection are discussed. The AIDS research agenda, based on systems originally designed to coordinate cancer research, involves a national effort to study various aspects of the disease,
Immunodiagnosis of feline immunodeficiency virus infection using recombinant viral p17 and p24.: AIDS. 1991 Dec;5(12):1477-83. Unique Identifier : AIDSLINE MED/92265231; Reid G; Rigby MA; McDonald M; Hosie MJ; Neil JC; Jarrett O; MRC Retrovirus Research Laboratory, University of Glasgow, UK.; The coding sequences of p17 and p24 of the Glasgow-8 strain of feline immunodeficiency virus (FIV) were amplified using the polymerase chain reaction and cloned into plasmid vectors. The predicted amino-acid sequences of FIV/Glasgow-8 p17 and p24 were compared with those of the Petaluma and PPR isolates of FIV. As see
Thromboembolic disease in AIDS is associated with cytomegalovirus disease [letter]: AIDS. 1991 Dec;5(12):1540-2. Unique Identifier : AIDSLINE MED/92265246; Jenkins RE; Peters BS; Pinching AJ
Statistics from the Centers for Disease Control [letter]: AIDS. 1991 Dec;5(12):1545-7. Unique Identifier : AIDSLINE MED/92265248
HCV seroprevalence in dialysis patients, their relatives and medical staff.: Rev Roum Virol. 1991 Jul-Dec;42(3-4):171-5. Unique Identifier : AIDSLINE MED/92265636; Capsa D; Cernescu S; Constantinescu SN; Cernescu C; Carol Davilla Hospital, Hemodialysis Unit, Bucharest, Romania.; HCV infection has emerged as a significant problem for both dialysis patients and medical staff. We report the data found in a dialysis center in Bucharest for hepatitis B, C and HIV infections. Single random samples collected from 133 dialysis patients give a seroprevalence of 91.7% for HCV antibodies in contrast wit
Interaction of human immunodeficiency virus type I Rev protein with nuclear scaffold nucleoside triphosphatase activity.: Cell Growth Differ. 1991 Nov;2(11):575-82. Unique Identifier : AIDSLINE MED/92265664; Clawson GA; Song YL; Schwartz AM; Shukla RR; Patel SG; Connor L; Blankenship L; Hatem C; Kumar A; Department of Pathology, Pennsylvania State University, Hershey; 17033.; Human immunodeficiency virus type I encodes a regulatory protein, termed Rev, which is associated with the appearance of unspliced and partially spliced viral RNAs in the cytoplasm. Rev is believed to function via interaction with a sequence element in the env region of the viral RNA, termed the Rev-responsive element
[Pneumocystis carinii pneumonia]: Pediatrie (Bucur). 1991;40(1-2):69-83. Unique Identifier : AIDSLINE MED/92265849; Dragomir D; Tauberg L; Popescu V; Clinica de Pediatrie, Spitalul Clinic Sf. Pantelimon, Bucuresti.; The paper reports on a theme of important pediatric interest, pneumonia with Pneumocystis carinii (PC), a more widespread affection lately, due to the progress in pediatric reanimation, on the one hand (that allowed the survival for a long time of several biologically handicapped infants) and as a consequence of the m
Feline leukaemia virus: generation of pathogenic and oncogenic variants.: Curr Top Microbiol Immunol. 1991;171:67-93. Unique Identifier : AIDSLINE MED/92266791; Neil JC; Fulton R; Rigby M; Stewart M; Beatson Institute for Cancer Research, Glasgow, UK.
Enhancement of monocyte antimycobacterial activity by diethyldithiocarbamate (DTC).: Int J Immunopharmacol. 1991;13(8):1067-72. Unique Identifier : AIDSLINE MED/92267726; Hubner L; Ernst M; von Laer D; Schwander S; Flad HD; Department of Immunology and Cell Biology, Forschungsinstitut; Borstel, F.R.G.; Diethyldithiocarbamate (DTC) has been recently reported to significantly reduce the incidence of opportunistic infections in HIV-infected patients. The present study addresses the question whether DTC is capable of stimulating antimycobacterial activity of mononuclear phagocytes. We found that peripheral blood mononuc
Pulmonary infections in the immunocompromised host.: J Assoc Physicians India. 1991 Aug;39(8):633-6. Unique Identifier : AIDSLINE MED/92267964; Soman RN; Sir HN Hospital, Bombay.
Neurological complications due to Semple-type antirabies vaccine. Clinical and therapeutic aspects [see comments]: J Assoc Physicians India. 1991 Sep;39(9):667-9. Unique Identifier : AIDSLINE MED/92267984; Swamy HS; Anisya V; Nandi SS; Kaliaperumal VG; National Institute of Mental Health and Neuro Sciences,; Bangalore.; Thirty nine patients with neuroparalytic accidents due to the use of Semple-type antirabies vaccine were studied. The mean age of the patients was 25.8 +/- 13.2 years. The suspected source of infection was the bite of a dog in 36 (92.3%) cases. The mean interval between the first dose of ARV and the onset of neurologi
AIDS and dentistry: ethical, legal, patient care and public policy issues.: Harv Dent Bull. 1991 Fall;1(2):13-8. Unique Identifier : AIDSLINE MED/92247852; Harvard Medical School.
A role for CD8+ T lymphocytes in the pathogenesis of AIDS.: Res Immunol. 1991 Sep;142(7):541-50. Unique Identifier : AIDSLINE MED/92253826; Aranda-Anzaldo A; Laboratoire d'Immunobiologie, Faculte de Medecine, Paris V.; Experimental and clinical evidence is presented which supports the hypothesis that CD8+ T lymphocytes aimed at suppressing HIV replication in infected CD4+ T cells may have an important role in the pathogenesis of AIDS by directly causing a decrease in CD4+ T lymphocyte numbers. Possible models to test this hypothesis
Analysis of synergism/antagonism between HIV-1 antibody-positive human sera and soluble CD4 in blocking HIV-1 binding and infectivity.: AIDS Res Hum Retroviruses. 1991 Dec;7(12):975-81. Unique Identifier : AIDSLINE MED/92256047; Kennedy MS; Orloff S; Ibegbu CC; Odell CD; Maddon PJ; McDougal JS; Immunology Branch, Centers for Disease Control, U.S. Public; Health Service, Atlanta GA 30333.; We tested human immunodeficiency virus type 1 (HIV-1) antibody-positive human sera and sCD4, alone and in combination, for synergistic, additive, or antagonistic effects on blocking of HIV binding and infectivity. Data were analyzed by an application of the median effect principle derived from the law of mass action.
Social, economic and operational research on tuberculosis: recent studies and some priority questions.: Bull Int Union Tuberc Lung Dis. 1991 Dec;66(4):149-56. Unique Identifier : AIDSLINE MED/92257177; Murray CJ; Center for Population and Development Studies, Harvard; University, Cambridge, MA 02138.; Social, economic and operational research has already contributed to the growing global awareness of the neglected burden of tuberculosis on individuals, families and communities. These studies have also illustrated that short-course chemotherapy for smear-positive pulmonary tuberculosis is a highly cost-effective too
The Mutual Assistance Programme of the IUATLD. Development, contribution and significance.: Bull Int Union Tuberc Lung Dis. 1991 Dec;66(4):159-72. Unique Identifier : AIDSLINE MED/92257178; Rouillon A; International Union Against Tuberculosis and Lung Disease, Paris,; France.; The Mutual Assistance Programme of the IUATLD is aimed at trying to compensate for the neglect into which tuberculosis had fallen from the part of governments, teaching institutions and international agencies, and represents an innovative approach to promote solidarity between governments and voluntary organizations o
The point of view of a high prevalence country: Malawi.: Bull Int Union Tuberc Lung Dis. 1991 Dec;66(4):173-4. Unique Identifier : AIDSLINE MED/92257179; Nyangulu DS; Ministry of Health of Malawi.; The National Tuberculosis Programme switched to short-course chemotherapy for smear-positive cases when the IUATLD started to assist in 1984. Treatment results in smear-positive cases improved from a 50-55% cure rate to an 87% cure rate in new cases (and 89% in retreatment cases). The hope of reducing the tuberculosis
Principles of IUATLD collaborative tuberculosis progammes.: Bull Int Union Tuberc Lung Dis. 1991 Dec;66(4):195-200. Unique Identifier : AIDSLINE MED/92257185; Enarson DA; University of Alberta, Department of Medicine, Edmonton, Canada.; The success of IUATLD-assisted National Tuberculosis Programme developed by Dr. Karel Styblo is dependent on a number of important principles. The most important step is the organization of the basic components of the National Tuberculosis Programme. This first step requires 1) a political commitment on the part of th
An emerging global programme against tuberculosis: agenda for research, including the impact of HIV infection.: Bull Int Union Tuberc Lung Dis. 1991 Dec;66(4):207-9. Unique Identifier : AIDSLINE MED/92257188; Murray JF; Chest Service, San Francisco General Hospital, Cal. 94110.; During the last 5 years, a worldwide resurgence of tuberculosis has been convincingly documented. Increased numbers of cases have been reported from several industrialized countries and there has been a veritable explosion of tuberculosis in the developing countries of sub-Saharan Africa. The fact that most of this in
Pharmacokinetics of anti-HIV nucleosides in microswine.: J Pharm Pharmacol. 1991 Dec;43(12):823-6. Unique Identifier : AIDSLINE MED/92260367; Swagler AR; Qian MX; Gallo JM; Department of Pharmaceutics, College of Pharmacy, University of; Georgia, Athens 30602.; The objective of the study was to determine if the micropig (Sus scrofa) would serve as an animal model for the anti-HIV nucleosides 3 -azido-3 -deoxythymidine ( AZT ), 2 ,3 -dideoxyinosine (ddI), and 2 ,3 -dideoxycytidine (
[T4 lymphocytes (helper cells) and T8 lymphocytes (cytotoxic and suppressor cells) in patients with asymptomatic and symptomatic HIV infection]: Pol Arch Med Wewn. 1991 Oct;86(4):239-46. Unique Identifier : AIDSLINE MED/92262323; Radkowski M; Laskus T; Kopicz-Kaminska E; Mian M; Babiuch L; Slusarczyk J; Zaklad Immunopatologii, Instytut Chorob Zakaznych i; Pasozytniczych Akademii Medycznej w Warszawie.; 250 determinations of lymphocyte T subsets in 130 HIV infected patients (79 asymptomatic carriers or with lymphadenopathy, 31 ARC- and 20 AIDS-patients) were analyzed as to the percentage, number, and ratio of T4 (helper) and T8 (cytotoxic/suppressor) lymphocytes in sequential clinical stages of HIV infection. Asympto
[Prospective studies of T4 and T8 lymphocyte subpopulations and beta 2-microglobulin in patients with HIV infection]: Pol Arch Med Wewn. 1991 Oct;86(4):247-53. Unique Identifier : AIDSLINE MED/92262324; Radkowski M; Laskus T; Kopicz-Kaminska E; Mian M; Babiuch L; Slusarczyk J; Zaklad Immunopatologii, Instytut Chorob Zakaznych i; Pasozytniczych Akademii Medycznej w Warszawie.; Sequential changes of percentage and number of T4 (helper) and T8 (cytotoxic/suppressor) lymphocyte subsets and serum beta 2 microglobulin (beta 2m) level were observed in 23 HIV infected patients for a period of 4 months to 3 years. 10 subjects were asymptomatic HIV carriers, 9 had already AIDS at the beginning of th
HIV-induced syncytium formation requires the formation of conjugates between virus-infected and uninfected T-cells in vitro.: AIDS. 1991 Dec;5(12):1425-32. Unique Identifier : AIDSLINE MED/92265224; Busso M; Thornthwaite J; Resnick L; Department of Retrovirology Research, Mount Sinai Medical Center,; Miami Beach, FL 33140.; The transmission of HIV requires the interaction of the cell-surface CD4 receptor and the viral envelope glycoprotein. Experiments were performed to determine the role of other cell-surface molecules in the development of HIV-induced syncytia. Although CEM and MT-2 cells had similar cell-surface CD4 receptor densities
The assembly of HIV within the Golgi apparatus and Golgi-derived vesicles of JM cell syncytia.: AIDS. 1991 Dec;5(12):1433-9. Unique Identifier : AIDSLINE MED/92265225; Grief C; Farrar GH; Kent KA; Berger EG; National Institute for Biological Standards and Control, South; Mimms, Hertfordshire, UK.; Chronic infection of the T-lymphocyte cell line JM with HIV-1 isolate GB8 results in the formation of multinucleate cells (syncytia). Transmission electron microscopy of these syncytia showed the presence of HIV particles both at the cell surface and within cytoplasmic vesicles. HIV particles were observed in dilated
Productive infection of T-helper lymphocytes with feline immunodeficiency virus is accompanied by reduced expression of CD4.: AIDS. 1991 Dec;5(12):1469-75. Unique Identifier : AIDSLINE MED/92265230; Willett BJ; Hosie MJ; Dunsford TH; Neil JC; Jarrett O; Department of Veterinary Pathology, University of Glasgow; Veterinary School, Scotland, UK.; An antigen-specific feline T-lymphocyte cell line (Q201) was generated and infected in vitro with the feline immunodeficiency virus (FIV). Syncytium formation and the release of the viral core protein p24 into culture fluid were accompanied by a reduction in expression of the CD4 surface antigen. The reduction in CD4
Statistical approaches to evaluating prognostic indices in HIV infection (reply) [letter; comment]: AIDS. 1991 Dec;5(12):1529. Unique Identifier : AIDSLINE MED/92265238; Burcham J
The AIDS virus. What we know and what we can do about it.: West J Med. 1991 Nov;155(5):481-7. Unique Identifier : AIDSLINE MED/92271477; Wong-Staal F; Department of Medicine, University of California, School of; Medicine, San Diego, La Jolla 92093-0613.
Angiogenesis and its inhibition: potential new therapies in oncology and non-neoplastic diseases.: Drug Des Discov. 1991 Nov;8(1):3-35. Unique Identifier : AIDSLINE MED/92239632; Billington DC; Institut de Recherches Servier, Suresnes, France.; To summarise the key points: The ability to mount an angiogenic response is probably present in all tissues, and stimulation of endothelial cells by any one of a wide variety of factors initiates a cascade of events leading to angiogenesis. In most tissues the overall lack of angiogenesis in normal situations probably
Novel naphthalenedisulfonic acid anti-HIV-1 agents. Synthesis and activity against reverse transcriptase, virus replication and syncytia formation.: Drug Des Discov. 1991 Nov;8(1):69-82. Unique Identifier : AIDSLINE MED/92239636; Mohan P; Singh R; Baba M; Department of Medicinal Chemistry and Pharmacognosy, College of; Pharmacy, University of Illinois, Chicago 60680.; Several naphthalenedisulfonic acid derivatives have been synthesized and evaluated in four anti-HIV-1 screens. Antiviral activity was evaluated in the assays that measure inhibition of HIV-1 reverse transcriptase (RT), HIV-1 induced giant cell (syncytia) formation, and HIV-1 induced cytopathogenicity in both a laborat
Role of interferon in clinical practice.: Ther Hung. 1991;39(4):159-66. Unique Identifier : AIDSLINE MED/92245529; Sreter L; Feher J; Second Department of Medicine, Semmelweis University Medical; School, Budapest.; Interferons are currently the most widely used biological response modifiers. They are of high clinical value in haematological malignancies (chronic myelogenous leukaemia, multiple myeloma, non-Hodgkin lymphoma), in solid tumours (malignant melanoma, hypernephroma, pancreas neoplasms, carcinoid tumours, Kaposi s sarc
Biological activity of novel macrocyclic alkaloids (budmunchiamines) from Albizia amara detected on the basis of interaction with DNA.: J Nat Prod. 1991 Nov-Dec;54(6):1531-42. Unique Identifier : AIDSLINE MED/92251355; Mar W; Tan GT; Cordell GA; Pezzuto JM; Jurcic K; Offermann F; Redl K; Steinke B; Wagner H; Department of Medicinal Chemistry and Pharmacognosy, College of; Pharmacy, University of Illinois, Chicago 60612.; Extracts derived from Albizia amara were found to demonstrate activity in a recently developed hplc system designed to detect compounds capable of interacting with DNA. Further investigation led to the procurement of four sets of alkaloid isolates X1-X4 that were found to be macrocyclic pithecolobine alkaloids. All fo
[Identification of varieties of Cryptococcus neoformans by the use of culture media]: Rev Cubana Med Trop. 1991 Apr-Aug;43(2):100-3. Unique Identifier : AIDSLINE MED/92253795; Fernandez Andreu C; Martinez Machin G; Menendez de San Pedro J; Oramas Rodriguez B; Laboratorio de Micologia, Instituto de Medicina Tropical Pedro; Kouri.; Ten Cryptococcus neoformans strains of human origin were studied in order to know their variety by using 2 different culture mediums: creatinine-bromothymol-blue-dextrose and glycine-cycloheximide-phenol red. The results obtained in the two mediums were not totally coincidental. The possible causes and the specificity
Ribosomal inhibitory proteins from plants inhibit HIV-1 replication in acutely infected peripheral blood mononuclear cells.: AIDS Res Hum Retroviruses. 1991 Dec;7(12):1025-30. Unique Identifier : AIDSLINE MED/92256043; Olson MC; Ramakrishnan S; Anand R; Department of Pharmacology, University of Minnesota, Minneapolis; 55455.; Peripheral blood mononuclear cells from seronegative donors were stimulated with phytohemagglutinin and then infected with human immunodeficiency virus (HIV-1). Using this experimental system, the antiviral activity of two translation inhibitory proteins (pokeweed antiviral protein, PAP-S, and Luffa ribosomal inhibito
Production and characterization of mouse monoclonal antibodies against the transmembrane protein of a human immunodeficiency virus type 2.: AIDS Res Hum Retroviruses. 1991 Dec;7(12):999-1005. Unique Identifier : AIDSLINE MED/92256050; Komatsu H; Yamashita A; Tozawa H; Mizutani Y; Honda M; Kawamura M; Hayami M; Department of Immunology, School of Hygienic Sciences, Kitasato; University, Sagamihara, Japan.; We established seven hybridoma clones producing monoclonal antibodies (MAbs) against the envelope transmembrane protein (TMP) of a Ghanian isolate of human immunodeficiency virus type 2 (HIV-2[GH-1]) from mice immunized with the detergent-disrupted purified whole virus. The MAbs were found to react with 35 kilodalton
The HIV-1 Rev protein: a model system for coupled RNA transport and translation.: New Biol. 1991 Dec;3(12):1220-32. Unique Identifier : AIDSLINE MED/92256307; Lawrence JB; Cochrane AW; Johnson CV; Perkins A; Rosen CA; Department of Cell Biology, University of Massachusetts Medical; Center, Worcester 01655.; The impact of the Rev protein of the human immunodeficiency virus type 1 (HIV-1) on RNA transport, intranuclear RNA distribution, and gene expression was examined for two Rev-dependent expression systems by means of fluorescence in situ hybridization, immunofluorescence, S1 nuclease protection, and functional assays.
The CD4 receptor: post binding events, conformational change and the second site.: Mol Aspects Med. 1991;12(4):255-65. Unique Identifier : AIDSLINE MED/92261267; Wilks D; Clinical Research Centre, Harrow, Middlesex, U.K.
A proposed molecular model for the carboxy terminus of HIV-1 gp120 showing structural features consistent with the presence of a T-cell alloepitope.: Mol Aspects Med. 1991;12(4):283-96. Unique Identifier : AIDSLINE MED/92261269; Hounsell EF; Renouf DV; Liney D; Dalgleish AG; Habeshaw J; Glycoconjugates Section, Clinical Research Centre, Harrow,; Middlesex, U.K.; A computer graphics molecular model of the C terminus of gp120 of HIV has been constructed using predicted secondary structure based on homologies with proteins for which X-ray crystallographic data have been published. The model shows sequences known to be important in CD4 binding in close proximity to regions with a
Vascular endothelium: a potential role in HIV infection and the pathogenesis of Kaposi's sarcoma: observations and speculations.: Mol Aspects Med. 1991;12(4):297-312. Unique Identifier : AIDSLINE MED/92261270; Kaul A; Pearson JD; Petty R; Williams DM; Dalgleish AG; Department of Oral Pathology, London Hospital Medical College,; Whitechapel, U.K.; Kaposi s sarcoma (KS) has become a source of interest in recent years primarily for its strong association with the acquired immune deficiency syndrome (AIDS). Endothelial cells (EC) are central to inflammation and can regulate coagulation and leucocyte emigration and may be central to the development of the disease.
Chemotherapy against human immunodeficiency virus infection.: Mol Aspects Med. 1991;12(4):313-28. Unique Identifier : AIDSLINE MED/92261271; Wilks D; Dalgleish AG; Clinical Research Centre, Harrow, Middlesex, U.K.
[Formation of phosphonoester bonds, catalyzed by DNA polymerases]: Mol Biol (Mosk). 1991 Nov-Dec;25(6):1688-700. Unique Identifier : AIDSLINE MED/92261583; Diatkina NB; Viktorova LS; Mozaherin DIu; Atrazhev AM; Rozenberg SG; Kukhanova MK; Kraevskii AA; 3 -Fluoro-2 ,3 -dideoxythymidine 5 -(alpha-methylphosphonyl)-beta, gamma-diphosphate (I) and 2 -deoxythymidine 5 -(alpha-methylphosphonyl)-beta,gamma-diphosphate (II) were synthesised. Reverse transcriptases of HIV and avian myeloblastosis virus, rat liver DNA polymerase beta, calf thymus terminal deoxynucleotidyl tra
[Hematopoietic growth factors]: Postepy Hig Med Dosw. 1991;45(6):461-96. Unique Identifier : AIDSLINE MED/92262351; Robak T; Pracownia Farmakologii Klinicznej Akademii Medycznej, Lodzi.; In the paper the role of interleukin-3, granulocyte-macrophage colony stimulating factor (GM-CSF), granulocyte-colony stimulating factor (G-CSF) and macrophage colony stimulating factor (M-CSF), in the proliferation and differentiation of haemopoietic cells and pathogenesis of leukaemia are reviewed. Role of erythropo
Inhibition of HIV-1 infection by alkylureas.: AIDS. 1991 Dec;5(12):1447-52. Unique Identifier : AIDSLINE MED/92265227; Goldstein H; Pettoello-Mantovani M; Kollmann TR; Calvelli TA; Rubinstein A; Department of Pediatrics, Albert Einstein College of Medicine,; Bronx, New York 10461.; The risk of infection by HIV-1 through transfusion of contaminated blood products has been markedly decreased but not eliminated by serological screening of donors. Methods are required to further minimize or eliminate the risk of infection of blood product recipients. We therefore examined the capacity of alkylureas
MS-8209, a new Amphotericin B derivative that inhibits HIV-1 replication in vitro and restores T-cell activation via the CD3/TcR in HIV-infected CD4+ cells.: AIDS. 1991 Dec;5(12):1453-61. Unique Identifier : AIDSLINE MED/92265228; Cefai D; Hadida F; Jung M; Debre P; Vernin JG; Seman M; Laboratoire d'Immunologie Cellulaire et Tissulaire, CERVI, La; Pitie-Salpetriere, Paris, France.; A new Amphotericin B derivative, MS-8209, which retains high antifungal activity with greatly reduced toxicity and improved solubility, has been developed. We investigated the antiviral properties of MS-8209 in Jurkat and CEM T-cell lines and in peripheral blood mononuclear cells infected in vitro with HIV-1BRU. Our r
Pharmacokinetics of intravenous pentosan polysulphate (HOE/BAY 946) in HIV-positive patients [letter]: AIDS. 1991 Dec;5(12):1534-5. Unique Identifier : AIDSLINE MED/92265242; Peters M; Witvrouw M; De Clercq E; Ruf B
Human immunodeficiency virus type 1 protease microinjected into cultured human skin fibroblasts cleaves vimentin and affects cytoskeletal and nuclear architecture.: J Cell Sci. 1991 Dec;100 ( Pt 4):799-807. Unique Identifier : AIDSLINE MED/92268231; Honer B; Shoeman RL; Traub P; Max-Planck-Institut fur Zellbiologie, Ladenburg bei Heidelberg,; Federal Republic of Germany.; In human skin fibroblasts microinjected with purified human immunodeficiency virus type 1 protease (HIV-1 PR), stress fibers were lost and alterations in nuclear morphology and condensation of nuclear chromatin were observed. Thereafter, the vimentin intermediate filament (IF) network collapsed. No effect was seen on
R-ELISA: repeated use of antigen-coated plates for ELISA and its application for testing of antibodies to HIV and other pathogens.: Biotechniques. 1992 Mar;12(3):412-7. Unique Identifier : AIDSLINE MED/92239141; Baunoch DA; Das P; Browning ME; Hari V; Department of Biological Sciences, Wayne State University,; Detroit, MI 48202.; In this paper we report on the evaluation of several procedures that allow for the repeated use of an antigen-coated, enzyme-linked immunosorbent assay (ELISA) plate for enzyme immunoassay (EIA). We have shown that antigen-coated ELISA plates that were incubated once with an aqueous solution containing 8 M urea, 2% so
Special issue dedicated to SIV.: AIDS Res Hum Retroviruses. 1992 Mar;8(3):325-421. Unique Identifier : AIDSLINE MED/92239208
Pathologic features of SIV-induced disease and the association of macrophage infection with disease evolution.: AIDS Res Hum Retroviruses. 1992 Mar;8(3):327-37. Unique Identifier : AIDSLINE MED/92239209; Simon MA; Chalifoux LV; Ringler DJ; Department of Pathology, Harvard Medical School, New England; Regional Primate Research Center, Southborough, MA.; Since the original isolation of simian immunodeficiency virus (SIV) from a macaque with an AIDS-like disease, numerous studies have demonstrated the close biologic and genetic relationship of the SIVs to the HIVs. Probably most important, the clinical spectrum of disease associated with SIVmac/SIVsmm infection in rhes
Malignant lymphoma associated with human AIDS and with SIV-induced immunodeficiency in macaques.: AIDS Res Hum Retroviruses. 1992 Mar;8(3):339-48. Unique Identifier : AIDSLINE MED/92239210; Feichtinger H; Kaaya E; Putkonen P; Li SL; Ekman M; Gendelman R; Biberfeld G; Biberfeld P; Department of Pathology, University of Innsbruck, Austria.; Malignant lymphomas associated with human (HIV) and simian (SIV) immunodeficiency virus infections are reviewed and compared. Recent observation of a high frequency of lymphomas in a series of cynomolgus macaques, highly immunodeficient after infection with SIVsm(smm3) are described. In addition to the increased frequ
The use of SIV-infected rhesus monkeys for the preclinical evaluation of AIDS drugs and vaccines.: AIDS Res Hum Retroviruses. 1992 Mar;8(3):349-56. Unique Identifier : AIDSLINE MED/92239211; Wyand MS; TSI Mason Laboratories, Worcester, MA 01068.; Macaque monkeys infected with the simian immunodeficiency virus (SIV) can be used for preclinical testing of drugs and vaccines against acquired immunodeficiency syndrome (AIDS) as well as for the study of AIDS pathogenesis. A number of pathogenic SIV strains that have been well characterized molecularly and biologica
Genetic variation of simian immunodeficiency viruses in nonhuman primates.: AIDS Res Hum Retroviruses. 1992 Mar;8(3):367-72. Unique Identifier : AIDSLINE MED/92239213; Johnson PR; Hirsch VM; Department of Pediatrics, Children's Hospital, Ohio State; University, Columbus.; The generation of biologically active proviral DNA clones of simian immunodeficiency virus (SIV) that give rise to infectious virions has allowed the detailed examination of genetic variation in experimentally inoculated monkeys. Studies of nucleotide sequences derived directly from circulating leukocytes of infected
The emergence of simian/human immunodeficiency viruses.: AIDS Res Hum Retroviruses. 1992 Mar;8(3):373-86. Unique Identifier : AIDSLINE MED/92239214; Myers G; MacInnes K; Korber B; Theoretical Division, Los Alamos National Laboratory, NM 87545.; Molecular evolutionary analyses strongly support the hypothesis that human immunodeficiency viruses have recently arisen from a diverse pool of nonhuman primate immunodeficiency viruses. Our understanding of the molecular phylogenetic relationships between primate and nonprimate lentiviruses is less certain, partly be
Genetic and biological comparisons of pathogenic and nonpathogenic molecular clones of simian immunodeficiency virus (SIVmac).: AIDS Res Hum Retroviruses. 1992 Mar;8(3):395-402. Unique Identifier : AIDSLINE GENBANK/M33262; Luciw PA; Shaw KE; Unger RE; Planelles V; Stout MW; Lackner JE; Pratt-Lowe E; Leung NJ; Banapour B; Marthas ML; Department of Medical Pathology, University of California, Davis; 95616.; Simian immunodeficiency virus (SIV) is a designation for a group of related but unique lentiviruses identified in several primate species. A viral isolate from a rhesus macaque (i.e., SIVmac) causes a fatal AIDS-like disease in experimentally infected macaques, and several infectious molecular clones of this virus hav
SIV/HIV recombinants and their use in studying biological properties.: AIDS Res Hum Retroviruses. 1992 Mar;8(3):403-9. Unique Identifier : AIDSLINE MED/92239217; Shibata R; Adachi A; Institute for Virus Research, Kyoto University, Japan.; A series of chimeric clones between human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency viruses (SIV) were constructed. Viability of the recombinant viruses was dependent on the position of recombination. Infectious chimeric viruses between HIV-1 and SIVAGM (isolated from an African green monkey) a
HIV with multiple gene deletions as a live attenuated vaccine for AIDS.: AIDS Res Hum Retroviruses. 1992 Mar;8(3):411-21. Unique Identifier : AIDSLINE MED/92239218; Desrosiers RC; New England Regional Primate Research Center, Harvard Medical; School, Southborough, MA 01772-9102.; Most viral vaccines currently in use in humans are live attenuated strains of virus that lack pathogenic potential. In general, such live attenuated vaccines induce the strongest longest-lasting immunity. Live attenuated strains of human immunodeficiency virus type 1 (HIV-1) have not been previously considered as vacc
Immune status of children on continuous ambulatory peritoneal dialysis.: Pediatr Nephrol. 1992 Mar;6(2):179-81. Unique Identifier : AIDSLINE MED/92239276; Hisano S; Miyazaki C; Hatae K; Kaku Y; Yamane I; Ueda K; Okamua S; Department of Paediatrics, Faculty of Medicine, Kyushu; University, Fukuoka, Japan.; Immunological parameters including serum IgG, IgA and IgM, lymphocyte phenotypes (CD3, CD4, CD8, HLA-DR+CD3-), natural killer cell activity and lymphocyte proliferation with phytohaemagglutinin were assessed in 10 children on continuous ambulatory peritoneal dialysis (CAPD) and 10 control subjects. Live vaccines were
Characterization of cells, immunoglobulins, and immune complexes present in the bronchoalveolar lavage of pediatric AIDS patients.: Reg Immunol. 1992 Jan-Feb;4(1):34-40. Unique Identifier : AIDSLINE MED/92239294; Nowakowski M; Clarke LM; Amaro R; Pellegrino MG; Sierra MF; Steiner P; Department of Pathology, State University of New York-Health; Science Center, Brooklyn 11203.; The role of local immunity in relation to the frequent and heterogeneous pulmonary manifestations of HIV-1 infection in children is poorly understood. In order to examine lung immunity in pediatric AIDS patients, the cellular composition, immunoglobulin, and immune complex (IC) levels were evaluated in 23 samples of b
Clinical and molecular aspects of molluscum contagiosum infection in HIV-1 positive patients.: Int J STD AIDS. 1992 Mar-Apr;3(2):101-6. Unique Identifier : AIDSLINE MED/92239487; Thompson CH; de Zwart-Steffe RT; Donovan B; Department of Infectious Diseases, University of Sydney,; Australia.; Molluscum contagiosum virus (MCV) lesions from 31 human immunodeficiency type 1 (HIV-1) positive patients and 54 HIV-1 negative adult control patients were examined for the presence and type of MCV DNA by high stringency Southern hybridization using 32P-labelled or digoxigenin-labelled MCV DNA probes. Of the 83 patien
Significance of Bacteroides ureolyticus in the lower genital tract.: Int J STD AIDS. 1992 Mar-Apr;3(2):107-10. Unique Identifier : AIDSLINE MED/92239488; Woolley PD; Kinghorn GR; Bennett KW; Eley A; Department of Genitourinary Medicine, Royal Hallamshire Hospital,; Sheffield, UK.; In a study to determine the significance of Bacteroides ureolyticus in the lower urogenital tract using a new selective and differential medium, this organism was isolated from 30.1% of asymptomatic men, 37.8% of men with genital warts, and 26.3% of men with non-gonococcal urethritis. Using the same selective medium B
Treatment of acute gonococcal infections in Bangkok with a dose range of the new cephalosporin, cefodizime.: Int J STD AIDS. 1992 Mar-Apr;3(2):111-6. Unique Identifier : AIDSLINE MED/92239489; Chitwarakorn A; Wongba C; Dagrosa EE; Schinzel B; Office for Communicable Disease Control, Region 1, Department of; Communicable Disease Control, Bangkok, Thailand.; In this randomized dose range study conducted in Bangkok, 326 patients with presumed acute uncomplicated gonorrhoea were treated with a single intramuscular dose of either 0.25 g, 0.5 g, or 1.0 g of a new aminothiazole cephalosporin, cefodizime. One hundred and eighty men and 110 women were evaluable for efficacy. Pat
Risk factors for Chlamydia trachomatis infection in 6810 young women attending family planning clinics.: Int J STD AIDS. 1992 Mar-Apr;3(2):117-22. Unique Identifier : AIDSLINE MED/92239490; Ramstedt K; Forssman L; Giesecke J; Granath F; University of Goteborg, Department of Dermato-Venereology,; Gothenburg, Sweden.; Screening programmes are important for the control of Chlamydia trachomatis (Ct) infection, a disease spread mainly by asymptomatic carriers. Risk factors for Ct infection were assessed in 6810 consecutive asymptomatic young women seeking contraceptive advice. All women filled in a questionnaire and were offered Ct te
Inflammatory cytology, infection and intraepithelial neoplasia.: Int J STD AIDS. 1992 Mar-Apr;3(2):123-4. Unique Identifier : AIDSLINE MED/92239491; Robinson AJ; Mercey DE; Preston M; Bingham JS; Department of Genitourinary Medicine, University College; Hospital, London, UK.; The prognostic implications of minor grades of abnormality on cervical cytology are unclear. Women attending genitourinary medicine clinics who had cytology showing inflammatory changes with or without koilocytosis or borderline dyskaryosis have a high incidence of cervical intraepithelial neoplasia and genital infect
Increasing workload of an HIV/AIDS counselling service in a London teaching hospital, 1990-91.: Int J STD AIDS. 1992 Mar-Apr;3(2):125-7. Unique Identifier : AIDSLINE MED/92239492; Bor R; Elford J; Richey L; Murray D; Salt H; Tilling J; Miller R; Johnson M; HIV/AIDS Unit, Royal Free Hampstead NHS Trust, London, UK.; The number of new patients referred to the HIV/AIDS Counselling Unit at the Royal Free Hospital, London, increased from 926 in 1989-90 to 1450 in 1990-91. Follow-up contacts nearly doubled during the same period of time. Growing demand for HIV testing as well as the shift to the treatment of HIV as a chronic condition
Balanitis (balanoposthitis) in patients attending a department of genitourinary medicine.: Int J STD AIDS. 1992 Mar-Apr;3(2):128-9. Unique Identifier : AIDSLINE MED/92239493; Abdullah AN; Drake SM; Wade AA; Walzman M; Department of Genitourinary medicine, Coventry and Warwickshire; Hospital, UK.; Eighty-six patients with balanitis/balanoposthitis who presented at the department of genitourinary medicine in Coventry between October 1989 and August 1990 were investigated. While 34 (41%) cases had no specific aetiological factor Candida spp. accounted for 26 cases (30%), and group B beta haemolytic streptococci f
Nebulized colistin (polymyxin E) for AIDS-associated Pseudomonas aeruginosa pneumonia.: Int J STD AIDS. 1992 Mar-Apr;3(2):130-1. Unique Identifier : AIDSLINE MED/92239494; Green ST; Nathwani D; Gourlay Y; McMenamin J; Goldberg DJ; Kennedy DH; Department of Infection and Tropical Medicine, Ruchill Hospital,; Glasgow, UK.
HIV infection, the brain and behaviour: major psychiatric disorder without cognitive impairment before or after the episode.: Int J STD AIDS. 1992 Mar-Apr;3(2):132-3. Unique Identifier : AIDSLINE MED/92239495; Dening TR; Klimes I; Catalan J; Rizza CR; Peto T; Fulbourn Hospital, Cambridge, UK.
Comparative recovery of Chlamydia from endocervical specimens using two types of plastic microtitre plates [letter]: Int J STD AIDS. 1992 Mar-Apr;3(2):136-7. Unique Identifier : AIDSLINE MED/92239497; Ravaoarinord M; Morisset R
Screening pregnant women for genital herpes [letter; comment]: Int J STD AIDS. 1992 Mar-Apr;3(2):137-8. Unique Identifier : AIDSLINE MED/92239498; Shen R; Mitchell S; Morton K; Thin RN
Breaking out of the rut: the use of alternative methodologies to measure AIDS-related attitudes and behaviour. Reply [letter; comment]: Int J STD AIDS. 1992 Mar-Apr;3(2):138. Unique Identifier : AIDSLINE MED/92239499; James NJ; Gillies PA; Bignell CJ
AIDS literature index.: Int J STD AIDS. 1992 Mar-Apr;3(2):141-55. Unique Identifier : AIDSLINE MED/92239500
HIV and pregnancy [editorial]: Int J STD AIDS. 1992 Mar-Apr;3(2):79-86. Unique Identifier : AIDSLINE MED/92239501; Johnstone FD
Are there still indications for single agent high-dose interferon-alpha against AIDS-associated Kaposi's sarcoma? [editorial]: Int J STD AIDS. 1992 Mar-Apr;3(2):87-91. Unique Identifier : AIDSLINE MED/92239502; de Wit R
The adolescent female prostitute and sexually transmitted diseases [editorial]: Int J STD AIDS. 1992 Mar-Apr;3(2):92-5. Unique Identifier : AIDSLINE MED/92239503; Markos AR; Wade AA; Walzman M; Prostitution may be seen as an adolescent s cry for help. A review into the background of the problem, the groups and individuals involved and the incidence of sexually transmitted diseases amongst them is presented. Psychological analysis and behavioural trends, especially in relation to attitudes towards sex, sexual
IDSA statement on healthcare workers with HIV infection 1991.: Clin Infect Dis. 1992 Jan;14(1):14. Unique Identifier : AIDSLINE MED/92239557
Aspergillus species colonization and invasive disease in patients with AIDS.: Clin Infect Dis. 1992 Jan;14(1):141-8. Unique Identifier : AIDSLINE MED/92239558; Pursell KJ; Telzak EE; Armstrong D; Department of Medicine, Memorial Sloan-Kettering Cancer Center,; New York, New York 10021.; Invasive aspergillosis is an uncommon infectious complication in patients with AIDS. Of the 972 patients with AIDS who were observed at our institution over a 10-year period, Aspergillus species were isolated from the respiratory sites of 45 patients before death. Invasive aspergillosis was documented at autopsy in fo
Norwegian scabies in a patient with AIDS.: Clin Infect Dis. 1992 Jan;14(1):162-4. Unique Identifier : AIDSLINE MED/92239562; Donabedian H; Khazan U; Department of Medicine, Medical College of Ohio, Toledo 43699.; Depression of cellular and humoral immunity can result in an overwhelming infection with the mite Sarcoptes scabiei. Infections in which the densities of mites are very high are known as Norwegian, or crusted, scabies. Cases of Norwegian scabies have been reported sporadically in patients with AIDS, but the appearance
Salvage therapy with clindamycin/primaquine for Pneumocystis carinii pneumonia.: Clin Infect Dis. 1992 Jan;14(1):183-8. Unique Identifier : AIDSLINE MED/92239566; Noskin GA; Murphy RL; Black JR; Phair JP; Department of Medicine, Northwestern University Medical School,; Chicago, Illinois 60611.; Clindamycin/primaquine is effective for treating mild-to-moderate cases of Pneumocystis carinii pneumonia (PCP) in patients with AIDS. We retrospectively reviewed our experience with this combination among patients in whom conventional therapy had failed or was not tolerated. Twenty-six patients who experienced 28 epi
Amyloidosis in association with human immunodeficiency virus infection [see comments]: Clin Infect Dis. 1992 Jan;14(1):189-91. Unique Identifier : AIDSLINE MED/92239567; Cozzi PJ; Abu-Jawdeh GM; Green RM; Green D; Department of Medicine, Northwestern University Medical School,; Chicago, Illinois.; Amyloidosis has not been previously reported in association with human immunodeficiency virus (HIV) infection. An HIV-infected patient with hemophilia who developed nephrotic syndrome due to amyloidosis is described. Amyloid disease has been observed in monkeys with AIDS, and patients with AIDS have had elevated level
Unusual manifestations of pneumococcal infection in human immunodeficiency virus-infected individuals: the past revisited.: Clin Infect Dis. 1992 Jan;14(1):192-9. Unique Identifier : AIDSLINE MED/92239568; Rodriguez Barradas MC; Musher DM; Hamill RJ; Dowell M; Bagwell JT; Sanders CV; Veterans Affairs Medical Center, Ben Taub General Hospital,; Houston, Texas.; Although AIDS was largely recognized and defined because of the increased presence of diseases that reflect deficiencies in cell-mediated immunity, susceptibility to common extracellular bacterial pathogens has also been shown to be increased. To our knowledge, adults with concurrent infection due to human immunodefic
The baron has AIDS: a case of factitious human immunodeficiency virus infection and review.: Clin Infect Dis. 1992 Jan;14(1):211-6. Unique Identifier : AIDSLINE MED/92239573; Zuger A; O'Dowd MA; Department of Medicine, Montefiore Medical Center, New York; 10467.; A 31-year-old cachectic intravenous drug user received treatment at in- and outpatient AIDS care facilities for almost one year before the diagnosis of Munchausen syndrome was established. Cases of factitious AIDS have been reported with increasing frequency since the onset of the AIDS epidemic. Patients typically giv
Chronic maxillary sinusitis associated with the mushroom Schizophyllum commune in a patient with AIDS.: Clin Infect Dis. 1992 Jan;14(1):46-8. Unique Identifier : AIDSLINE MED/92239604; Rosenthal J; Katz R; DuBois DB; Morrissey A; Machicao A; Division of Infectious Diseases, Case Western Reserve University,; Cleveland, Ohio.; Invasive infection with fungi of the Basidiomycota (rusts, smuts, toadstools, mushrooms, and puffballs) is extremely rare. We report such an infection in a patient with human immunodeficiency virus disease who presented with chronic maxillary sinusitis associated with the mushroom Schizophyllum commune. The organism w
Invasive aspergillosis in patients with AIDS.: Clin Infect Dis. 1992 Jan;14(1):66-74. Unique Identifier : AIDSLINE MED/92239608; Minamoto GY; Barlam TF; Vander Els NJ; Division of Allergy, Clinical Immunology, and Infectious; Diseases, St. Luke's/Roosevelt Hospital Center, New York, New; York 10025.; Invasive aspergillosis is a rare complication of AIDS. We discuss the cases of 18 patients with AIDS and invasive aspergillosis who were identified at our institution and 19 patients who are described in the literature. Twenty-one patients were either homosexual or bisexual, eight were intravenous drug users, three we
Pulmonary manifestations of acquired immunodeficiency syndrome.: Clin Infect Dis. 1992 Jan;14(1):98-113. Unique Identifier : AIDSLINE MED/92239612; Meduri GU; Stein DS; Division of Pulmonary and Critical Care Medicine, University of; Tennessee Medical Center, Memphis.; In at least 65% of patients with acquired immunodeficiency syndrome (AIDS), the lung is the site for life-threatening illness. To establish a basis for understanding the pulmonary pathology of such illness, we first review briefly the effects of the human immunodeficiency virus on the immune system and then review the
HIV-related infections of the oral cavity.: Crit Rev Oral Biol Med. 1992;3(3):207-31. Unique Identifier : AIDSLINE MED/92239615; Ficarra G; Shillitoe EJ; Institute of Odontology and Stomatology, University of Florence,; Italy.; Oral infections are among the first manifestations of infection by the human immunodeficiency virus (HIV). They include fungal, viral, and bacterial infections and range from being essentially trivial, through troublesome to life threatening. Although some infections are due to overproliferation of the normal oral flo
Changing causes of death in Pennsylvania's hemophiliacs 1976 to 1991: impact of liver disease and acquired immunodeficiency syndrome [letter]: Blood. 1992 May 1;79(9):2494-5. Unique Identifier : AIDSLINE MED/92239913; Eyster ME; Schaefer JH; Ragni MV; Gorenc TJ; Shapiro S; Cutter S; Kajani MK; Abrams J; Barron LE; Odenwelder A; et al
[Epidemiology of HIV infections in Switzerland and the German Federal Republic--contribution of official surveillance systems, of anonymous testing and of blood donor screening]: Gesundheitswesen. 1992 Mar;54(3):122-6. Unique Identifier : AIDSLINE MED/92240080; Estermann J; Sulliger JM; Skarabis H; Bundesamt fur Gesundheitswesen, Bern.; Official records on HIV infections are useful instruments to register and demonstrate the spread of the virus in the population observed. The data resulting from the registries allow the estimation of the means and the variabilities of age, sex and the probable path of infection in the observed population. In
New dispute over royalties for HIV test [news]: BMJ. 1992 Mar 14;304(6828):660. Unique Identifier : AIDSLINE MED/92240123; Connor S
Ethical modifications of the Emergency Drug Release Program for AIDS: a proposal [editorial]: Can Med Assoc J. 1992 May 1;146(9):1541-5. Unique Identifier : AIDSLINE MED/92240516; Gill MJ; Burgess MM; Kinsella TD
[Psychosocial aspects of certain fundamental needs of families with a child with HIV infection]: Can J Public Health. 1992 Jan-Feb;83(1):42-6. Unique Identifier : AIDSLINE MED/92240533; Taggart ME; Reidy M; Asselin L; Faculte des sciences infirmieres, Universite de Montreal.; The presence of a family of a young child with AIDS, with the exception of a small number of transfusion-infected children, implies almost necessarily the presence of infected adults, usually the mother. The problem in such a situation is not that of a child with a fatal illness but that of an entire family. Our study
The Talking Sex Project: descriptions of the study population and correlates of sexual practices at baseline.: Can J Public Health. 1992 Jan-Feb;83(1):47-52. Unique Identifier : AIDSLINE MED/92240534; Myers T; Tudiver FG; Kurtz RG; Jackson EA; Orr KW; Rowe CJ; Bullock SL; Department of Health Administration, Community Health Division,; Toronto, Ontario, Canada.; The Talking Sex Project is an HIV risk reduction education project for gay and bisexual men. It was developed to evaluate two types of small discussion groups using a randomized control study design. This paper reports on the baseline measures of knowledge, attitudes and sexual practices. The 612 subjects had a mean a
B cell responses to HIV and the development of human monoclonal antibodies.: Clin Exp Immunol. 1992 May;88(2):189-202. Unique Identifier : AIDSLINE MED/92240830; Boyd JE; James K; Department of Surgery, University Medical School, Edinburgh, UK.; In this review B cell responses in HIV-infected individuals are summarized together with the techniques used to date to produce human monoclonals to HIV and the properties of these antibodies. Profound disturbances in B cell responses are apparent both in vivo and in vitro. While there is evidence in vivo of marked po
Prolonged clinically asymptomatic evolution after HIV-1 infection is marked by the absence of complement C4 null alleles at the MHC.: Clin Exp Immunol. 1992 May;88(2):237-42. Unique Identifier : AIDSLINE MED/92240836; Hentges F; Hoffmann A; Oliveira de Araujo F; Hemmer R; Department of Immuno-Allergology, Centre Hospitalier de; Luxembourg.; The length of time after which persons infected with HIV-1 progress to AIDS is variable. Certain alleles at the MHC have been shown to influence negatively the clinical outcome of HIV-1-infected persons and to be associated with special clinical manifestations. We investigated the MHC class I, class II and class III a
The Ontario HIV seroprevalence study of childbearing women: results from the first year of testing.: Clin Invest Med. 1992 Feb;15(1):1-7. Unique Identifier : AIDSLINE MED/92240883; Coates RA; Frank JW; Arshinoff R; Major C; Wallace E; Millson ME; McLaughlin B; Demshar H; Khazen R; Garbutt J; et al; Dept of Preventive Medicine and Biostatistics, Faculty of; Medicine, University of Toronto, Ontario.; The Ontario HIV Seroprevalence Study of Childbearing Women is an unliked anonymous seroprevalence study designed according to the well-established ethical and legal guidelines for such studies. Commencing in November, 1989, randomly selected neonatal heelprick specimens were tested for the presence of HIV antibodies a
The long-term effects of aerosol pentamidine on pulmonary function. The Toronto Aerosolized Pentamidine Study (TAPS) Group.: Clin Invest Med. 1992 Feb;15(1):42-8. Unique Identifier : AIDSLINE MED/92240886; Tullis E; Yu DG; Rawji M; Rachlis A; Hyland R; Chan CK; Department of Medicine, Wellesley Hospital, Toronto, Ontario.; Aerosolized pentamidine (AP) has been widely used for prophylaxis of pneumocystis carinii pneumonia (PCP) since 1988. The objective of this study was to evaluate the long-term effects of AP on pulmonary function. Of 36 patients with AIDS who were receiving AP for secondary prophylaxis of PCP, 13 patients had been usin
Comparison of enzyme-linked immunosorbent and indirect immunofluorescence assays for the detection of human T-cell lymphotropic virus type-I antibodies in sera from rural Haiti.: Diagn Microbiol Infect Dis. 1992 Feb;15(2):121-4. Unique Identifier : AIDSLINE MED/92240919; Grant W; Bia FJ; Chacko TM; Jean-Baptiste M; Griffith BP; Virology Reference Laboratory, VA Medical Center, West Haven, CT; 06516.; Serum samples were obtained from 340 healthy individuals without evidence of neurologic disease living in rural Haiti . Sera were screened for antibodies to human T-cell lymphotropic virus type I (HTLV-I) using two commercially available enzyme immunoassays (EIA) and by an indirect i
AIDS and family planning counseling of psychiatrically ill women in community mental health clinics.: Community Ment Health J. 1992 Feb;28(1):13-20. Unique Identifier : AIDSLINE MED/92240941; Coverdale JH; Aruffo JF; Department of Psychiatry and Behavioral Sciences, Baylor College; of Medicine, Houston, Texas.; Eighty-two of 83 mental health professionals, including psychiatrists, were surveyed to determine their attitudes and behaviors toward AIDS prevention and family planning counseling with psychiatrically ill female outpatients. Nearly all reported that information should be provided on AIDS and family planning. However
[The informing of other physicians of an HIV finding]: Dtsch Med Wochenschr. 1992 Apr 24;117(17):678-9. Unique Identifier : AIDSLINE MED/92241099; Rieger HJ
Pituitary epithelial cell implants reverse the accumulation of CD4-CD8- lymphocytes in thymus glands of aged rats.: Endocrinology. 1992 May;130(5):2703-9. Unique Identifier : AIDSLINE MED/92241168; Li YM; Brunke DL; Dantzer R; Kelley KW; Department of Animal Sciences, University of Illinois, Urbana; 61801.; Although implantation of GH3 pituitary epithelial cells has been shown to reverse thymic aging in rats, the differentiation pattern of T-lymphocytes within the reconstituted thymus glands has not been investigated. Syngeneic GH3 cells were implanted into 22-month-old female (old) Wistar-Furth rats. Eight weeks later,
Trichosanthin treatment of HIV-induced immune dysregulation.: Eur J Clin Invest. 1992 Feb;22(2):113-22. Unique Identifier : AIDSLINE MED/92241367; Mayer RA; Sergios PA; Coonan K; O'Brien L; R. A. Mayer Clinic, Department of Research and Development, North; Miami, Florida.; Twenty patients with the acquired immunodeficiency syndrome (AIDS), AIDS-related complex (ARC) or asymptomatic HIV infection (HIV+) were given 20 mcg kg-3 trichosanthin (TCS; Compound Q ), a ribosome-inactivating protein with in vitro antiviral activity against human immunodeficiency virus (HIV) once every four weeks
Epidemiology of infection with HIV-1 in Sardinia: a multicentre prospective study.: Eur J Epidemiol. 1992 Jan;8(1):132-5. Unique Identifier : AIDSLINE MED/92241424; Farci P; Novick DM; Orgiana G; Coiana A; Lai ME; Mandas A; Strazzera A; Marongiu F; Chessa L; Lusso P; et al; Istituto di Medicina Interna, Universita di Cagliari, Italy.; To study the spread of human immunodeficiency virus type 1 (HIV-1) in Sardinia, we conducted a multicentre prospective study of the prevalence of antibody to HIV-1 (anti-HIV-1) in various populations during 1985-1989. The highest anti-HIV-1 prevalence (61.4%) was found in intravenous drug users. Anti-HIV-1 was found i
No evidence of HIV-2 infection amongst HIV-1 Ab positive people in the largest cities of north-eastern Italy [letter]: Eur J Epidemiol. 1992 Jan;8(1):140-1. Unique Identifier : AIDSLINE MED/92241426; Costigliola P; Ricchi E; Manfredi R; Tumietto F; Barelli A; Borri A; De Rosa V; Chiodo F
Hospital-based surveillance of HIV infection: epidemiological trends in Bordeaux, France 1983-1989. The Groupe D'epidemiologie Clinique du SIDA en Aquitaine (GECSA).: Eur J Epidemiol. 1992 Jan;8(1):58-66. Unique Identifier : AIDSLINE MED/92241434; Chene G; Dabis F; Salamon R; INSERM Unite n. 330, Departement d'Informatique Medicale,; Universite de Bordeaux II, France.; A hospital-based surveillance system of infection by the human immunodeficiency virus (HIV) has been implemented in nine wards of the Bordeaux University Hospital by the Groupe d Epidemiologie Clinique du SIDA en Aquitaine (GECSA). The aim was to systematically collect clinical, biological and epidemiological data on
Schizophrenia and AIDS [letter]: Hosp Community Psychiatry. 1992 Feb;43(2):181. Unique Identifier : AIDSLINE MED/92241833; Rector NA; Seeman MV
HIV-1 in inpatients [letter]: Hosp Community Psychiatry. 1992 Feb;43(2):181-2. Unique Identifier : AIDSLINE MED/92241834; Lee HK; Travin S; Bluestone H
HIV infection of monocytes inhibits the T-lymphocyte proliferative response to recall antigens, via production of eicosanoids.: Immunology. 1992 Mar;75(3):391-7. Unique Identifier : AIDSLINE MED/92241922; Foley P; Kazazi F; Biti R; Sorrell TC; Cunningham AL; Centre for Infectious Diseases and Microbiology, University of; Sydney, Westmead Hospital, New South Wales, Australia.; Human monocytes infected in vitro with human immunodeficiency virus (HIV) soon after adherence to plastic substrate demonstrated a significantly decreased ability to restimulate autologous immune T-lymphocyte proliferation after exposure to soluble (tetanus toxoid) and particulate [herpes simplex virus (HSV)] antigen.
Facing terminal illness in children with AIDS. Developing a philosophy of care for patients, families, and caregivers.: Home Healthc Nurse. 1992 Mar-Apr;10(2):40-3. Unique Identifier : AIDSLINE MED/92242097; Gary GA; To effectively meet the multiple care needs of AIDS/HIV patients and their families, healthcare professionals must gain awareness and sensitivity to their own concepts of death and dying as well as what it means to be a child in our society.
AIDS and the vascular surgeon [editorial]: J Cardiovasc Surg (Torino). 1992 Mar-Apr;33(2):139-42. Unique Identifier : AIDSLINE MED/92242259; Royle JP; The presence of the HIV virus has introduced a new risk to the surgeon and the operating team. Vascular and cardiac surgeons are at a higher risk of percutaneous exposure to blood than many other surgical groups. Re-examination of basic surgical techniques enables the development of strategies for the handling of inst
An international collaborative study to assess a set of reference reagents for HIV-1 PCR.: J Virol Methods. 1992 Apr;37(1):23-41. Unique Identifier : AIDSLINE MED/92242405; Bootman JS; Kitchin PA; MRC PCR Reference Centre, AIDS Collaborating Centre, NIBSC,; Potters Bar, Herts, UK.; An international collaborative study was performed to evaluate a set of PCR reference reagents for HIV diagnosis. Twenty-six laboratories from 9 countries analysed a proficiency panel of 10 coded DNA samples using the PCR reference reagents and protocols. For comparison, these coded samples were then assessed using a
Chemical inactivation of human immunodeficiency virus in vitro.: J Virol Methods. 1992 Apr;37(1):71-81. Unique Identifier : AIDSLINE MED/92242408; Aranda-Anzaldo A; Viza D; Busnel RG; C.N.R.S., Laboratoire d'Immunobiologie, Faculte de Medecine,; Paris, France.; Most chemicals with potential virucidal activity are extremely cytotoxic even at very small concentrations, thus introducing a number of technical problems and uncertainties in the evaluation of the net virucidal effect. In the present study, an attempt was made to confirm the reported virucidal activity of certain we
Sensitivity of the polymerase chain reaction for detecting human T-cell leukemia virus type I sequences in paraffin-embedded tissue. Effect of unbuffered formalin fixation.: J Virol Methods. 1992 Apr;37(1):83-8. Unique Identifier : AIDSLINE MED/92242409; Ohara Y; Honma M; Iwasaki Y; Department of Neurological Sciences, Tohoku University School of; Medicine, Sendai, Japan.; Recently, the application of the polymerase chain reaction (PCR) to formalin-fixed paraffin-embedded tissue has been reported. But formalin, especially unbuffered formalin, is known to break DNA into small fragments. DNA extracted from MT-2 cells fixed in unbuffered formalin for various periods of time were subjected
Depressed mood and its relationship to neuropsychological test performance in HIV-1 seropositive individuals.: J Clin Exp Neuropsychol. 1992 Mar;14(2):289-97. Unique Identifier : AIDSLINE MED/92242427; Hinkin CH; van Gorp WG; Satz P; Weisman JD; Thommes J; Buckingham S; UCLA School of Medicine 90024.; The relationship between depression and neuropsychological test performance in HIV-1 seropositive individuals is unclear. The present study was conducted to determine whether different patterns of neuropsychological test performance would be present in depressed vs. nondepressed individuals infected by the Human Immun
Nonmycetomic Actinomadura madurae infection in a patient with AIDS.: J Clin Microbiol. 1992 Apr;30(4):1008-10. Unique Identifier : AIDSLINE MED/92242435; McNeil MM; Brown JM; Scalise G; Piersimoni C; Mycotic Diseases Branch, Centers for Disease Control, Atlanta,; Georgia 30333.; Actinomadura madurae is an aerobic actinomycete which is best known worldwide as the cause of actinomycotic mycetomas. It has not previously been reported to have caused invasive pulmonary or disseminated infection in humans. We describe an AIDS patient with opportunistic A. madurae-induced pneumonia and bacteremia. T
Reactivity patterns and infection status of serum samples with indeterminate Western immunoblot tests for antibody to human immunodeficiency virus type 1.: J Clin Microbiol. 1992 Apr;30(4):801-5. Unique Identifier : AIDSLINE MED/92242458; Ramirez E; Uribe P; Escanilla D; Sanchez G; Espejo RT; Virology Unit, Faculty of Medicine, University of Chile,; Santiago.; Serum samples with indeterminate Western blot (WB) tests from 61 individuals whose sera were positive by enzyme-linked immunosorbent assay (ELISA) were studied in order to characterize their putative reactions with the human immunodeficiency virus (HIV) proteins and to resolve the HIV infection status of these individ
Comparison of three nonradioisotopic polymerase chain reaction-based methods for detection of human immunodeficiency virus type 1.: J Clin Microbiol. 1992 Apr;30(4):845-53. Unique Identifier : AIDSLINE MED/92242465; Whetsell AJ; Drew JB; Milman G; Hoff R; Dragon EA; Adler K; Hui J; Otto P; Gupta P; Farzadegan H; et al; Northwestern University, Chicago, Illinois 60611.; Three nonradioisotopic polymerase chain reaction (PCR)-based detection techniques were evaluated for sensitivity and specificity in detecting human immunodeficiency virus type 1 (HIV-1) proviral DNA in peripheral blood mononuclear cells. The Roche prototype HIV-1 PCR assay, the Du Pont enzyme-linked oligonucleotide sa
Infection of peripheral blood mononuclear cells and cell lines by cell-free human T-cell lymphoma/leukemia virus type I.: J Clin Microbiol. 1992 Apr;30(4):905-10. Unique Identifier : AIDSLINE MED/92242476; Fan N; Gavalchin J; Paul B; Wells KH; Lane MJ; Poiesz BJ; Department of Microbiology and Immunology, SUNY Health Science; Center, Syracuse.; Previous studies of in vitro infection by human T-cell lymphoma/leukemia virus type I (HTLV-I) have required cocultivation of target cells with HTLV-I cell lines or vesicular stomatitis virus pseudotypes containing HTLV-I envelope proteins. We report here the development of a cell-free infection assay for HTLV-I. Targ
Development of DNA probes for early diagnosis and epidemiological study of cryptococcosis in AIDS patients.: J Clin Microbiol. 1992 Apr;30(4):925-30. Unique Identifier : AIDSLINE MED/92242480; Polacheck I; Lebens G; Hicks JB; Department of Clinical Microbiology and Infectious Diseases,; Hadassah Medical Center, Jerusalem, Israel.; We report the isolation of middle-repetitive DNA sequences from Cryptococcus neoformans that are species and variety specific. These probes were used for assessing strain relatedness among cryptococcal isolates from patients with and without AIDS who were from Zaire and the
Genetic similarity and maintenance of Candida albicans strains from a group of AIDS patients, demonstrated by DNA fingerprinting.: J Clin Microbiol. 1992 Apr;30(4):935-41. Unique Identifier : AIDSLINE MED/92242482; Schmid J; Odds FC; Wiselka MJ; Nicholson KG; Soll DR; Department of Biology, University of Iowa, Iowa City 52242.; By using the computer-assisted Dendron system to analyze the patterns of Southern blots probed with the repetitive sequence Ca3, we have compared oral isolates of Candida spp. from a group of 11 nonhospitalized patients with AIDS suffering from recurrent episodes of oral thrush
Detection of antibody to immunodeficiency viruses by dot immunobinding assay.: J Clin Microbiol. 1992 Apr;30(4):993-5. Unique Identifier : AIDSLINE MED/92242492; Kalter SS; Heberling RL; Barry JD; Kuramoto IK; Holland PV; Sazama K; Virus Reference Laboratory, Inc., San Antonio, Texas 78229.; The dot immunobinding assay (DIA), a modified enzyme immunoassay (EIA), has been demonstrated to be a highly sensitive and specific assay for the detection of antibody to a number of viruses. Different laboratory procedures are available for detecting antibody to the immunodeficiency viruses; however, these procedures
Nurses' willingness to perform AIDS patient care.: J Contin Educ Nurs. 1992 May-Jun;23(3):110-7. Unique Identifier : AIDSLINE MED/92242620; Kemppainen J; St. Lawrence JS; Irizarry A; Weidema DR; Benne C; Fredericks CD; Wilson M; We evaluated nurses from hospitals with different prevalences of AIDS patients and with different levels of nursing education to measure their willingness to provide care to AIDS patients. Nurses who were most experienced in AIDS patient care, employed in high-prevalence hospitals, and who considered themselves most k
ICN takes stand on HIV-positive nurses in the workplace [news]: J Adv Nurs. 1992 Mar;17(3):273. Unique Identifier : AIDSLINE MED/92242651
Who will care? A survey of the knowledge and attitudes of hospital nurses to people with HIV/AIDS.: J Adv Nurs. 1992 Mar;17(3):400-1. Unique Identifier : AIDSLINE MED/92242667; Akinsanya JA; Rouse P; Faculty of Health and Social Work, Anglia Polytechnic,; Chelmsford, Essex, England.
HIV education for gay, lesbian, and bisexual youth: personal risk, personal power, and the community of conscience.: J Homosex. 1992;22(3-4):247-59. Unique Identifier : AIDSLINE MED/92242883; Cranston K; Massachusetts Department of Education, Bureau of Student; Development and Health, Quincy 02169-5183.; Adolescent gay and bisexual males face a higher risk of infection with HIV than most other young people because of their behaviors and because HIV prevention programs have failed to address their unique concerns. Ironically, current efforts to heighten public awareness about the AIDS pandemic may be nullifying the pot
The auto-regulation model: a unified concept of how HIV regulates its infectivity, pathogenesis and persistence.: Int Rev Immunol. 1992;8(1):1-32. Unique Identifier : AIDSLINE MED/92243011; Layne SP; Dembo M; Theoretical Division, University of California, Los Alamos; National Laboratory, New Mexico 87545.; The life cycle of HIV can be divided into two distinct stages: intracellular and extracellular. The prevailing view is that the intracellular stage provides the only locus for regulating the virus in response to physiologic stimuli. Such regulation is accomplished by modulating the rates of transcription, translation
Virus infections and cytokines: can we manage the interactions?: Int Rev Immunol. 1992;8(1):33-41. Unique Identifier : AIDSLINE MED/92243012; Bowen JC; Daniel S; Rouse BT; Department of Microbiology, College of Veterinary Medicine,; University of Tennessee, Knoxville 37996-0845.
Interferon alpha (IFN)-macrophage interactions in human immunodeficiency virus (HIV) infection: role of IFN in the tempo and progression of HIV disease.: Int Rev Immunol. 1992;8(1):43-54. Unique Identifier : AIDSLINE MED/92243013; Gendelman HE; Skillman DR; Meltzer MS; Department of Cellular Immunology, Walter Reed Army Institute of; Research, Rockville, Maryland.; Components of the host immune response that constrain virus replication and affect long-lasting antiviral immunity following HIV infection are incompletely defined. IFNs are critical participants in host antiviral processes. While IFN induces significant anti-retroviral activities, they also serve as harbingers for po
SIV infection of macaques as a model for AIDS pathogenesis.: Int Rev Immunol. 1992;8(1):55-63. Unique Identifier : AIDSLINE MED/92243014; Johnson PR; Hirsch VM; Department of Pediatrics, Children's Hospital, Ohio State; University, Columbus.; Simian immunodeficiency virus (SIV) infection of macaques is the best available animal model for studying the pathogenesis of AIDS. Experimental inoculation of macaques with SIV results in a persistent infection that leads to immunodeficiency, opportunistic infections, and death. Most aspects of the illness, including
Respiratory failure and death from HIV-associated myopathy.: J Ky Med Assoc. 1992 Apr;90(4):174-7. Unique Identifier : AIDSLINE MED/92243022; Altobellis SS; Roy TM; Joyce BW; Byrd RP Jr; University of Louisville School of Medicine.; As increasing numbers of patients with HIV infection enter the medical system, the neuromuscular problems caused by this retrovirus are better defined. Recent attention has focused on the development of myopathy and/or polyneuropathy in patients with the acquired immune deficiency syndrome. We report a patient whose i
Mycobacteria and AIDS.: J Fla Med Assoc. 1992 Mar;79(3):175-6. Unique Identifier : AIDSLINE MED/92243093; Blanchard DK; Department of Medical Microbiology and Immunology, University of; South Florida College of Medicine.; Mycobacteria are acid-fast, slow-growing microorganisms which have gained attention due to increasing prevalence in AIDS patients. Until the advent of AIDS, the only true pathogens of this group were Mycobacterium tuberculosis and M. leprae and the remaining mycobacteria were considered to be saprophytes or opportunis
Human T-cell lymphotropic virus type 1 infection and tropical spastic paraparesis in Belgian expatriates.: J Med Virol. 1992 Jan;36(1):13-5. Unique Identifier : AIDSLINE MED/92243098; Goubau P; Carton H; Cornet P; Vercauteren G; Van Gompel A; De Vooght H; Piot P; Desmyter J; Department of Microbiology, Rega Institute, University Hospitals,; Leuven, Belgium.; A case of HTLV-1 associated tropical spastic paraparesis is described in a Belgian nun who had been working as a midwife in Central Africa. Occupational exposure was the only risk factor identified. Among 2,482 Belgian expatriates in tropical countries, 92% of whom had resided in sub-Saharan Africa for an average of 1
Changing medical students' attitudes about AIDS.: J Okla State Med Assoc. 1992 Jan;85(1):11-4. Unique Identifier : AIDSLINE MED/92243210; Johnson J; Hustzi HC; Mullins LL; Adolescent Medicine Section, CHO 4N207, Oklahoma City, OK; 73104-5066.; Medical students may have negative attitudes about persons with the acquired immunodeficiency syndrome (AIDS) as well as concerns about occupational infection with human immunodeficiency virus. We conducted a brief intervention to assess and modify attitudes of first-year students. The intervention was presented to sm
Science transcends politics [editorial]: J Okla State Med Assoc. 1992 Feb;85(2):57. Unique Identifier : AIDSLINE MED/92243217; McIntyre RV
The feasibility of mandatory HIV testing for health professionals and other special populations.: J Okla State Med Assoc. 1992 Feb;85(2):74-80. Unique Identifier : AIDSLINE MED/92243220; Smallwood KG; Adult Medicine Clinic, OUHSC, Tulsa 74129.; Infection with the human immunodeficiency virus (HIV) has become an increasingly important public health problem. Due to the profound increase in the incidence of the disease, testing has become an important tool in prevention efforts as well as treatment. In view of the dire prognosis associated with the diagnosis of
Routine HIV testing?--You bet! [see comments]: J Okla State Med Assoc. 1992 Feb;85(2):81-2. Unique Identifier : AIDSLINE MED/92243221; Forsythe RL
5,425 cases so far. Most health care workers with AIDS don't get the disease on the job [news]: J Okla State Med Assoc. 1992 Feb;85(2):85. Unique Identifier : AIDSLINE MED/92243222
Cryptococcal meningitis associated with acquired immunodeficiency syndrome (AIDS) in African patients: treatment with fluconazole.: J Med Vet Mycol. 1992;30(1):71-8. Unique Identifier : AIDSLINE MED/92243305; Laroche R; Dupont B; Touze JE; Taelman H; Bogaerts J; Kadio A; M'Pele P; Latif A; Aubry P; Durbec JP; et al; I.M.T.S.S.A. Le Pharo, Marseille, France.; Cryptococcal meningitis associated with acquired immunodeficiency syndrome (AIDS) is particularly common in tropical Africa. This could be explained by the dramatic increase in the number of human immunodeficiency virus (HIV) infections and the high prevalence of Cry
NAPNAP president's message: the issue of AIDS.: J Pediatr Health Care. 1992 Mar-Apr;6(2):109-10. Unique Identifier : AIDSLINE MED/92243308; Clore ER
Preparing preschool programs to care for children with HIV infection.: J Pediatr Health Care. 1992 Mar-Apr;6(2):60-4. Unique Identifier : AIDSLINE MED/92243311; Urbano MT; Von Windeguth BJ; As a consequence of the increasing incidence and prevalence of HIV infection, preschools are seeking help in developing and implementing nondiscriminatory policies. Pediatric nurse practitioners are in an ideal position to provide leadership in adapting preschool programs to meet the special health care needs of these
Update on AIDS/HIV.: J Pediatr Health Care. 1992 Mar-Apr;6(2):94-7. Unique Identifier : AIDSLINE MED/92243318; Havens DH; Associated with the AIDS epidemic are some of the most difficult policy dilemmas society faces. The issues surrounding HIV are complex and involve legal, medical, ethical, and practice issues. In addition, many policy issues have received and will continue to receive attention--education, public health measures, healt
HLA and infection.: J R Coll Physicians Lond. 1992 Jan;26(1):11-6. Unique Identifier : AIDSLINE MED/92243372; Hill AV; John Radcliffe Hospital, Oxford.
Conception of AIDS and its prevention among students in a Nigerian university.: J R Soc Health. 1992 Apr;112(2):59-63. Unique Identifier : AIDSLINE MED/92243424; Odebiyi AI; Obafemi Awolowo University, Ile-Ife, Nigeria.; This study examines AIDS awareness, knowledge of transmission and prevention among students, who not only belong to the sexually active age bracket, but who are the future leaders of the nation. The student population was stratified into those in the health and non-health disciplines and an accidental sampling techniq
Synthesis and biological studies of unsaturated acyclonucleoside analogues of S-adenosyl-L-homocysteine hydrolase inhibitors.: J Med Chem. 1992 Apr 17;35(8):1435-9. Unique Identifier : AIDSLINE MED/92243443; Hasan A; Srivastava PC; Health and Safety Research Division, Oak Ridge National; Laboratory, Tennessee 37831-6022.; The design, synthesis, and biological evaluation of several unsaturated acyclonucleosides related to augustmycin A are described. The (propargyloxy)methyl acyclonucleoside analogues of 6-chloropurine, adenine, 6-methoxypurine, hypoxanthine, 6-mercaptopurine, and azathioprine have been prepared. The 9-[(propargyloxy)me
Synthesis and anti-HIV activity of 4'-azido- and 4'-methoxynucleosides.: J Med Chem. 1992 Apr 17;35(8):1440-51. Unique Identifier : AIDSLINE MED/92243444; Maag H; Rydzewski RM; McRoberts MJ; Crawford-Ruth D; Verheyden JP; Prisbe EJ; Syntex Research, Palo Alto, California 94304.; A series of nucleosides were synthesized in which the 4 -hydrogen was substituted with either an azido or a methoxy group. The key steps in the syntheses of the 4 -azido analogues were the stereo- and regioselective addition of iodine azide to a 4 -unsaturated nucleoside precursor followed by an oxidatively assisted d
A startling 19,000-word thesis on the origin of AIDS: should the JME have published it? [editorial] [see comments]: J Med Ethics. 1992 Mar;18(1):3-4. Unique Identifier : AIDSLINE MED/92243456; Gillon R
Ethics and ethics committees: HIV serosurveillance in Scotland.: J Med Ethics. 1992 Mar;18(1):43-6. Unique Identifier : AIDSLINE MED/92243459; Tappin DM; Cockburn F; Samson Gemmell Chair of Child Health, Royal Hospital for Sick; Children, Yorkhill, Glasgow.; Knowledge of the heterosexual spread of HIV is needed to plan future health-care needs. In December 1989 we gained approval and finance for unlinked anonymous testing of neonatal Guthrie card samples in Scotland. Local ethics committee approval was required before testing could start. Twenty ethics committees were app
From the Centers for Disease Control. Selected behaviors that increase risk for HIV infection among high school students--US, 1990.: JAMA. 1992 May 13;267(18):2448-9. Unique Identifier : AIDSLINE MED/92243583
TB or not TB, that is the question [letter; comment]: JAMA. 1992 May 13;267(18):2471-2. Unique Identifier : AIDSLINE MED/92243590; Jolson HM; Behrman RE
TB or not TB, that is the question [letter; comment]: JAMA. 1992 May 13;267(18):2472. Unique Identifier : AIDSLINE MED/92243591; Ciesielski S; Seed JR; Esposito D
The effect of zidovudine on patient subgroups [letter; comment]: JAMA. 1992 May 13;267(18):2472-3. Unique Identifier : AIDSLINE MED/92243592; Hamilton JD; Hartigan PM; Simberkoff MS
Sexual practices in the transmission of hepatitis B virus and prevalence of hepatitis delta virus infection in female prostitutes in the United States.: JAMA. 1992 May 13;267(18):2477-81. Unique Identifier : AIDSLINE MED/92243594; Rosenblum L; Darrow W; Witte J; Cohen J; French J; Gill PS; Potterat J; Sikes K; Reich R; Hadler S; Hepatitis Branch, Centers for Disease Control, Atlanta, Ga.; 30333.; OBJECTIVE--To evaluate heterosexual transmission of hepatitis B virus (HBV) and the prevalence of hepatitis delta virus (HDV) infection in female prostitutes. DESIGN--Survey. SETTING--Sexually transmitted disease clinics, drug treatment programs, detention centers, and/or outreach efforts in eight areas in the
Comparisons of hospital care for patients with AIDS and other HIV-related conditions.: JAMA. 1992 May 13;267(18):2482-6. Unique Identifier : AIDSLINE MED/92243595; Andrulis DP; Weslowski VB; Hintz E; Spolarich AW; Hospital Institute, Washington, DC 20005.; OBJECTIVE--To compare utilization and financing of inpatient care for persons with the acquired immunodeficiency syndrome (AIDS) (as defined by the Centers for Disease Control) and those with other HIV [human immunodeficiency virus]-related illness. DESIGN--A mailed survey of the members of five national organizations
Government extinguishes marijuana access, advocates smell politics [news]: JAMA. 1992 May 20;267(19):2573-4. Unique Identifier : AIDSLINE MED/92243602; Cotton P
Nosocomial transmission of tuberculosis in a hospital unit for HIV-infected patients [see comments]: JAMA. 1992 May 20;267(19):2632-4. Unique Identifier : AIDSLINE MED/92243625; Dooley SW; Villarino ME; Lawrence M; Salinas L; Amil S; Rullan JV; Jarvis WR; Bloch AB; Cauthen GM; Division of Tuberculosis Elimination, National Center for; Infectious Diseases, Centers for Disease Control, Atlanta, GA; 30333.; OBJECTIVE--To assess nosocomial transmission of tuberculosis (TB). DESIGN--A historical cohort study of hospitalized patients with the human immunodeficiency virus (HIV) and a purified protein derivative (PPD) tuberculin skin test survey of health care workers (HCWs). SETTING--A large public teaching hospital in San J
Tuberculosis control. Back to the future? [editorial; comment]: JAMA. 1992 May 20;267(19):2649-50. Unique Identifier : AIDSLINE MED/92243629; Gordin F
Disclosure of HIV status of health care workers supported [letter; comment]: J Emerg Nurs. 1992 Apr;18(2):97-8. Unique Identifier : AIDSLINE MED/92243730; Keeney C
[The acquired immunodeficiency syndrome in the elderly]: Med Clin (Barc). 1992 Mar 28;98(12):461-4. Unique Identifier : AIDSLINE MED/92243860; Antuna Egocheaga A; Moris de la Tassa J; Gutierrez del Rio C; Estrada Rato F; Garcia-Alcalde Fernandez ML; Servicio de Medicina Interna, Hospital de Cabuenes, Gijon,; Asturias.; Three cases of AIDS in patients older than 60 years of age are presented and are characterized by the delay in diagnosis even in the face of suggestive clinical manifestations because of the lack of suspicion leading to fatal short term evolution in all the cases. The importance of HIV infection and its characteristic
[Clindamycin desensitization in a patient with the acquired immunodeficiency syndrome (letter)]: Med Clin (Barc). 1992 Mar 28;98(12):478-9. Unique Identifier : AIDSLINE MED/92243869; Martin JA; Alonso MD; Navas E; Antela A
Cost-effectiveness of prophylactic AZT following needlestick injury in health care workers.: Med Decis Making. 1992 Apr-Jun;12(2):142-8. Unique Identifier : AIDSLINE MED/92244007; Ramsey SD; Nettleman MD; Department of Internal Medicine, University of Washington,; Seattle.; In response to health care workers concerns about contracting infection with the human immunodeficiency virus (HIV) in the workplace, several institutions now offer prophylactic azido-deoxythymidine ( AZT ) for needlesticks sustained while exposed to H
[New vaccines]: Mikrobiyol Bul. 1992 Jan;26(1):82-9. Unique Identifier : AIDSLINE MED/92244113; Ozisik A; Ustacelebi S; Uzm., Dr. Hacettepe Universitesi Tip Fakultesi Mikrobiyoloji; Anabilim Dali.; In this article, schedule for active immunization of normal infants and children in the routine strategy have been reviewed and some of the new vaccines were defined.
AIDS' impact on professional health care practice issues.: Neonatal Netw. 1992 Apr;11(3):57-8. Unique Identifier : AIDSLINE MED/92244148; Pompa K
Transmission of AIDS from blood screened negative for antibody to the human immunodeficiency virus [letter]: N Engl J Med. 1992 May 28;326(22):1499-500. Unique Identifier : AIDSLINE MED/92244323; Conley LJ; Holmberg SD
Hand preference, immune system disorder and cognitive function among gay/bisexual men: the Multicenter AIDS Cohort Study (MACS).: Neuropsychologia. 1992 Mar;30(3):229-35. Unique Identifier : AIDSLINE MED/92244448; Becker JT; Bass SM; Dew MA; Kingsley L; Selnes OA; Sheridan K; Department of Psychiatry, University of Pittsburgh, PA.; This study evaluated the self-reported patterns of handedness among a large subsample (n = 1612) of the gay/bisexual men comprising the Multicenter AIDS Cohort Study (MACS). There was a small but significant elevation in left-handedness among gay/bisexual men compared to available normative data. However, there were n
Viral politics: an end to the game [letter]: N J Med. 1992 Mar;89(3):185. Unique Identifier : AIDSLINE MED/92244488; Perry AW
AIDS--the second decade--working together!: N J Med. 1992 Mar;89(3):195. Unique Identifier : AIDSLINE MED/92244491
Mycobacterium haemophilum osteomyelitis in an AIDS patient.: N J Med. 1992 Mar;89(3):201-2. Unique Identifier : AIDSLINE MED/92244493; Gupta I; Kocher J; Miller AJ; Weisholtz SJ; Perz J; Scully M; Department of Internal Medicine, Englewood Hospital.; Mycobacterium haemophilum is a fastidious species that has been isolated from skin and subcutaneous nodules. The authors describe a case of Mycobacterium haemophilum osteomyelitis and skin infection in an AIDS patient and successful treatment with minocycline.
AIDS-related Pneumocystis pneumonia complicated by diffuse pneumatocele formation.: N Y State J Med. 1992 Jan;92(1):20-1. Unique Identifier : AIDSLINE MED/92244521; Jacob CN; Henein S; Hill AR; Division of Pulmonary Medicine, State University of New York; Health Science Center, Brooklyn, NY 11203.
T lymphocyte subsets and function in the peripheral blood of patients with urological cancer.: Oncology. 1992;49(2):108-13. Unique Identifier : AIDSLINE MED/92244550; Kaver I; Pecht M; Trainin N; Greenstein A; Braf Z; Department of Urology, Tel Aviv Medical Center, Sackler School of; Medicine, Tel Aviv University, Israel.; The phenotypic distribution and immune reactivity of T lymphocyte subpopulations from peripheral blood of 50 patients with urological cancer were determined. Included were 36 patients with bladder transitional cell carcinoma, 7 patients with renal cell carcinoma and 7 patients with prostatic carcinoma. Thirty-eight ag
Terminal care limited for AIDS.: Nurs Times. 1992 Apr 8-14;88(15):7. Unique Identifier : AIDSLINE MED/92244742; Carlisle D
Pioneer with AIDS dies [news]: Nurs Times. 1992 Apr 8-14;88(15):9. Unique Identifier : AIDSLINE MED/92244743; Mason P
Collecting HIV data without compromising anonymity [letter]: Nurs Times. 1992 Apr 15-21;88(16):14. Unique Identifier : AIDSLINE MED/92244744; Fern S
Growing concern.: Nurs Times. 1992 Apr 29-May 5;88(18):40-2. Unique Identifier : AIDSLINE MED/92244780; Carnegie A; Rutter J
Detection of antibodies to Pneumocystis carinii in bronchoalveolar lavage fluid by immunoreactivity to Pneumocystis carinii within alveoli, granulomas, and disseminated sites.: Mod Pathol. 1992 Mar;5(2):107-13. Unique Identifier : AIDSLINE MED/92244887; Blumenfeld W; McCook O; Griffiss JM; Department of Pathology, VA Medical Center, San Francisco,; California.; Although Pneumocystis carinii pneumonia (PCP) is the most common major opportunistic infection in the acquired immunodeficiency syndrome (AIDS), its immunopathogenesis is not fully understood. It is known that anti-pneumocystis antibodies are present in the sera of individuals with and without PCP. In order to determi
Maintaining an equal standard of care. HIV and the neonate.: Prof Nurse. 1992 Apr;7(7):457-60. Unique Identifier : AIDSLINE MED/92244914; Yellott G
Neuropsychological findings and psychiatric symptoms in HIV-1 infected and noninfected drug users.: Psychiatry Res. 1992 Feb;41(2):163-77. Unique Identifier : AIDSLINE MED/92244983; Pakesch G; Loimer N; Grunberger J; Pfersmann D; Linzmayer L; Mayerhofer S; Department of Psychiatry, University of Vienna, Austria.; Reports available on the extent and incidence of cognitive deficits in human immunodeficiency virus (HIV-1) patients are variable. To assess the influence of drug abuse and psychiatric symptoms on the extent of the cognitive deficit, we examined 42 drug-addicted HIV-1 patients and compared them with a group of seroneg
Evidence for a systemic immune activation during depression: results of leukocyte enumeration by flow cytometry in conjunction with monoclonal antibody staining.: Psychol Med. 1992 Feb;22(1):45-53. Unique Identifier : AIDSLINE MED/92245009; Maes M; Lambrechts J; Bosmans E; Jacobs J; Suy E; Vandervorst C; de Jonckheere C; Minner B; Raus J; Psychiatric Centre, Munsterbilzen, Belgium.; Several studies have reported a suppressed immune function (e.g. blast transformation) during depression. In an attempt to define the cellular basis of the reported immune disorders, the present study investigates the leukocyte cell subset profile of minor, simple major, and melancholic depressives, versus normal cont
Oligodeoxynucleotides as antisense inhibitors of gene expression.: Prog Nucleic Acid Res Mol Biol. 1992;42:79-126. Unique Identifier : AIDSLINE MED/92245081; Ghosh MK; Cohen JS; Pharmacology Department, Georgetown University Medical School,; Washington, D.C. 20007.
Oxidative stress, HIV and AIDS.: Res Immunol. 1992 Feb;143(2):145-8. Unique Identifier : AIDSLINE MED/92245182; Papadopulos-Eleopulos E; Turner VF; Papadimitriou JM; Department of Medical Physics, Royal Perth Hospital, Western; Australia.
Risk perception, risk taking and risk management among intravenous drug users: implications for AIDS prevention.: Soc Sci Med. 1992 Mar;34(6):591-601. Unique Identifier : AIDSLINE MED/92245397; Connors MM; University of Massachusetts, Ricards International Inc.,; Washington, DC 20009.; The risks associated with AIDS transmission among intravenous drug users overlap with a constellation of other risk events common in the use of IV drugs. This paper explores the subcultural definition, meaning and use of risk from the experience of the active user. In assessing the extent and nature of risk among IV d
HIV in the U.K.: problems of prevalence, sociological response and health education.: Soc Sci Med. 1992 Mar;34(6):697-707. Unique Identifier : AIDSLINE MED/92245407; Winn S; Skelton R; Department of Community Studies, Brighton Polytechnic, Falmer,; U.K.; It is argued that the prevalence of AIDS is substantially under-represented in existing national AIDS data. Thus although official statistics demonstrate significant recent shifts in transmission routes for HIV, health educators are faced with a problem because it is difficult to develop preventive strategies against
HIV and HTLV-I survey in Venda [letter]: S Afr Med J. 1992 May 2;81(9):485. Unique Identifier : AIDSLINE MED/92245434; Taylor MB; Janse van Rensburg E; Swanevelder C; Carlier ND; Glatthaar E
Agenda on AIDS.: Tex Med. 1992 Mar;88(3):33. Unique Identifier : AIDSLINE MED/92245514
HIV-infected health-care workers: Texas law.: Tex Med. 1992 Mar;88(3):48-9. Unique Identifier : AIDSLINE MED/92245516; Wilcox DP
Finding may calm fears about AIDS in bone transplants [news]: Tex Med. 1992 Apr;88(4):25. Unique Identifier : AIDSLINE MED/92245522
My patient population is predominantly female. Are they at any significant risk from HIV infection?: Tex Med. 1992 Apr;88(4):57. Unique Identifier : AIDSLINE MED/92245525
Pediatric AIDS cases blamed on mothers.: Tex Med. 1992 Apr;88(4):57. Unique Identifier : AIDSLINE MED/92245526
Postnatal human immunodeficiency virus antibody testing. The effects of current policy on infant care and maternal informed consent.: West J Med. 1992 Apr;156(4):371-5. Unique Identifier : AIDSLINE MED/92245688; Lester P; Partridge JC; Cooke M; School of Medicine, University of California, San Francisco.; Routine human immunodeficiency virus (HIV) antibody screening of umbilical cord blood identifies neonates at risk for HIV infection but may hold risks as well as benefits for infants and mothers. We describe the effect of testing on infant placement and care and report the women s understanding of pretest counseling a
Needle-stick injuries among health care professionals.: West J Med. 1992 Apr;156(4):409. Unique Identifier : AIDSLINE MED/92245695; Ferguson TJ
Impact of HIV infection on mycobacterial disease.: Am Fam Physician. 1992 May;45(5):2203-11. Unique Identifier : AIDSLINE MED/92246044; Mehta JB; Morris F; James H. Quillen College of Medicine of East Tennessee State; University, Johnson City.; The current epidemic of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome has resulted in a worldwide resurgence of tuberculosis. In the United States , the number of new cases of tuberculosis has increased in the past five years, leading to a cumulativ
Coulter counter identifies Cryptococcus neoformans as leukocytes. A case of pseudopleocytosis.: Am J Clin Pathol. 1992 May;97(5):663-4. Unique Identifier : AIDSLINE MED/92246153; Berger SA; Waitman DA; Baruch R; Department of Microbiology, Tel Aviv Sourasky Medical Center,; Israel.; Cerebrospinal fluid from a 42-year-old man with acquired immune deficiency syndrome was processed in a Coulter S-plus counter and found to contain 4.8 x 10(9) leukocytes/L:56.1% granulocytes and 37.7% lymphocytes. Direct examination of the same specimen in a counting chamber revealed that the leukocytes were cells of
Bacillary epithelioid angiomatosis involving the liver, spleen, and skin in an AIDS patient with concurrent Kaposi's sarcoma.: Am J Clin Pathol. 1992 May;97(5):713-8. Unique Identifier : AIDSLINE MED/92246161; Steeper TA; Rosenstein H; Weiser J; Inampudi S; Snover DC; Department of Pathology, Metropolitan-Mount Sinai Medical Center,; Minneapolis, Minnesota.; The simultaneous findings of bacillary epithelioid angiomatosis and Kaposi s sarcoma of the skin with visceral hepatosplenic bacillary epithelioid angiomatosis is reported in a patient with acquired immune deficiency syndrome. Liver biopsy showed periportal peliotic spindle cell foci that initially were misinterpreted
Pneumocystis carinii of the orbit [letter]: Am J Ophthalmol. 1992 May 15;113(5):595-6. Unique Identifier : AIDSLINE MED/92246196; Friedberg DN; Warren FA; Lee MH; Vallejo C; Melton RC
AIDS policy: guidelines for outpatient psychiatric services. American Psychiatric Association.: Am J Psychiatry. 1992 May;149(5):721. Unique Identifier : AIDSLINE MED/92246245
AIDS policy: guidelines for inpatient psychiatric units. American Psychiatric Association.: Am J Psychiatry. 1992 May;149(5):722. Unique Identifier : AIDSLINE MED/92246246
Tuberculosis and the surgeon.: Am J Surg. 1992 May;163(5):505-9. Unique Identifier : AIDSLINE MED/92246276; Langdale LA; Meissner M; Nolan C; Ashbaugh DG; Department of Surgery, University of Washington, Seattle.; With the resurgence of active tuberculosis in the United States , surgeons may be called upon to participate in the management of primary tuberculosis as well as major complications of the disease. To define the role of surgery in the diagnosis and treatment of tuberculosis in the 1990s
[Long-term follow-up study of 35 children with ADS treated with zidovudine (AZT)]: An Esp Pediatr. 1992 Feb;36(2):98-108. Unique Identifier : AIDSLINE MED/92246413; de Jose Gomez MI; Gonzalez de Dios J; Mellado Pena MJ; Garcia Miguel MJ; Garcia Rodriguez MC; Cilleruelo Ortega MJ; Martinez Zapico R; Fernandez Calle P; Martin Fontelo P; Servicio de Infecciosos, Hospital Infantil La Paz, Madrid.; Thirty-five children diagnosed of AIDS were studied in order to evaluate toxicity and efficacy of oral Zidovudine treatment ( AZT ), as well as to analyze the clinical, biochemical, immunological and virological evolution of HIV infection throughout the
Nonmelanoma skin cancers and infection with the human immunodeficiency virus.: Arch Dermatol. 1992 May;128(5):623-7. Unique Identifier : AIDSLINE MED/92246557; Lobo DV; Chu P; Grekin RC; Berger TG; Department of Dermatology, University of California, San; Francisco.; BACKGROUND AND DESIGN--Forty-eight human immunodeficiency virus-infected patients with nonmelanoma skin cancers seen during a four-year period were evaluated in a retrospective, case-control study. Patients were followed up after therapy and recurrence rates were determined. RESULTS--One hundred and sixteen nonmelanom
Anetoderma and human immunodeficiency virus infection.: Arch Dermatol. 1992 May;128(5):661-2. Unique Identifier : AIDSLINE MED/92246566; Ruiz-Rodriguez R; Longaker M; Berger TG; Department of Dermatology, San Francisco General Hospital, CA; 94110.; BACKGROUND--Autoimmune disorders such as vitiligo and alopecia areata have been reported in persons infected with the human immunodeficiency virus (HIV). OBSERVATIONS--Three HIV-infected men had anetoderma develop early in the course of their HIV infection. In two patients this preceded other features of HIV disease,
[Heart surgery and human immunodeficiency virus]: Arch Mal Coeur Vaiss. 1992 Mar;85(3):341-4. Unique Identifier : AIDSLINE MED/92246684; Sousa Uva M; Massonnet Castel S; Jebara V; Fabiani JN; Acar C; Desgranges P; Carpentier A; Departement de chirurgie cardiovasculaire, hopital Broussais,; Paris.; The authors report their experience of cardiac surgery in 9 carriers of the human immunodeficiency virus (HIV). Eight HIV seropositive patients underwent surgery under cardiopulmonary bypass for valve repair or replacement. Eight patients were asymptomatic with respect to their viral infection: one patient had general
Chemical glycosylation of peptide T at natural and artificial glycosylation sites stabilizes or rearranges the dominant reverse turn structure.: Biochem Biophys Res Commun. 1992 Apr 30;184(2):1125-32. Unique Identifier : AIDSLINE MED/92246931; Urge L; Gorbics L; Otvos L Jr; Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.; Peptide T (H-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-OH), a fragment of HIV gp120, has been reported to inhibit binding of the virus to the CD4 receptor. The peptide assumes a beta-turn secondary structure, and stabilization of the conformation may increase the biological activity. We synthesized the octapeptide and its C-ter
Inhibition of HIV-1 protease by short peptides derived from the terminal segments of the protease.: Biochem Biophys Res Commun. 1992 Apr 30;184(2):980-5. Unique Identifier : AIDSLINE MED/92246995; Schramm HJ; Breipohl G; Hansen J; Henke S; Jaeger E; Meichsner C; Riess G; Ruppert D; Rucknagel KP; Schafer W; et al; Max-Planck-Institut fur Biochemie, Martinsried, Germany.; The active HIV-1 protease is a homodimeric enzyme. A beta-sheet consisting of N- and C-terminal segments provides the main driving force for dimerization of the inactive protomers. Several short peptides with sequences derived from the N- and C-termini of the protease were tested for inhibition of protease activity an
CD4(81-92)-based peptide derivatives. Structural requirements for blockade of HIV infection, blockade of HIV-induced syncytium formation, and virostatic activity in vitro.: Biochem Pharmacol. 1992 Apr 15;43(8):1785-96. Unique Identifier : AIDSLINE MED/92247015; Rausch DM; Lifson JD; Padgett MP; Chandrasekhar B; Lendvay J; Hwang KM; Eiden LE; Unit on Molecular and Cellular Biology, National Institute of; Mental Health, Bethesda, MD 20892.; CD4(81-92) peptide block human immunodeficiency virus (HIV) infection, virus-induced cell fusion, and antigen production by HIV-1-infected cells when derivatized on specific amino acid residues. An extensive series of structural variants of 1,4,5-tribenzyl-10-acetyl-CD4(81-92) were tested as anti-viral agents in an at
Potential influences of residencies' health risk policies on their rankings by Ohio applicants.: Acad Med. 1992 May;67(5):340-1. Unique Identifier : AIDSLINE MED/92247223; Painter AF; Barnes HV; Markert RJ; Gillen JC; Good Samaritan Hospital and Health Center, Department of Medical; Education, Dayton, OH 45406.; Residents health risks constitute an area of increasing concern for hospitals and residencies. This study examined the importance of health risk policies in the context of students selection of residencies. In 1991, all 836 fourth-year students in six Ohio medical schools were surveyed about their attitudes regardin
[Nutrition of HIV-positive persons and patients with AIDS. Still, one has to eat...]: TVZ. 1992 Mar 19;(6):212-4. Unique Identifier : AIDSLINE MED/92247356; de Jong H
Metabolism of 2',3'-dideoxyinosine (ddI) in human blood.: Br J Clin Pharmacol. 1992 Mar;33(3):319-22. Unique Identifier : AIDSLINE MED/92247608; Back DJ; Ormesher S; Tjia JF; Macleod R; Department of Pharmacology and Therapeutics, University of; Liverpool.; 1. 2 ,3 -Dideoxyinosine (ddI) has potent activity against human immunodeficiency virus (HIV). It is converted within target cells to its active form dideoxyadenosine triphosphate(ddA-TP). 2. In addition to the intracellular formation of ddA-TP, ddI can be broken down to hypoxanthine, by purine nucleoside phosphorylase
New drug treatments for HIV infection and AIDS. A review following the Seventh International Conference on AIDS, Florence 16-21 June 1991.: Br J Clin Pharmacol. 1992 Mar;33(3):349-56. Unique Identifier : AIDSLINE MED/92247616; Venning GR; Scott GM; Department of Microbiology, University College Hospital, London.; 1. OBJECTIVE--To evaluate the status of clinical development of zidovudine and new drugs for the treatment of Human Immunodeficiency Virus (HIV) infections. 2. METHOD--A critical review of the clinical trial reports and assessment of the design and methodology of the therapeutic trials. Evaluation of the drugs being t
[Epidemiologic characteristics of pneumococcal bacteremia in the era of AIDS]: Enferm Infecc Microbiol Clin. 1992 Mar;10(3):138-42. Unique Identifier : AIDSLINE MED/92247858; Teira R; Munoz J; Zubero Z; Rojo P; Cisterna R; Santamaria JM; Seccion de Enfermedades Infecciosas, Hospital Civil de Bilbao.; BACKGROUND: The HIV infection and the development of penicillin-resistant pneumococci justify the review of the epidemiologic features of pneumococcal pneumonia in the last years. METHOD: A retrospective chart review of all patients admitted between 1987 and 1990 with a positive blood culture to Streptococcus pneumoni
[Campylobacter bacteremia and HIV infection]: Enferm Infecc Microbiol Clin. 1992 Mar;10(3):155-7. Unique Identifier : AIDSLINE MED/92247862; Vargas J; Corzo JE; Perez MJ; Lozano F; Martin E; Seccion de Microbiologia, Hospital Universitario de Valme,; Sevilla.; Bacteremia due to Campylobacter is a rare infection. Patients with HIV infection are an important risk group for this condition. We describe here two patients with Campylobacter bacteremia and advanced HIV infection. One case was due to C. jejuni infection in a drug addict, being also isolated C. jejuni in stool sampl
[Itchy rash in an HIV-positive patient]: Enferm Infecc Microbiol Clin. 1992 Mar;10(3):173-5. Unique Identifier : AIDSLINE MED/92247867; del Pozo LJ; Merino FJ; Alfaro J; Sanchez R; Unidad de Dermatologia, Hospital General del INSALUD, Soria.
Human B-cell TNF-beta microheterogeneity.: Lymphokine Cytokine Res. 1992 Feb;11(1):45-54. Unique Identifier : AIDSLINE MED/92247941; Benjamin D; Kofler G; Tschachler E; Lymphokine Research Laboratory, Arthur G. James Cancer Hospital,; Ohio State University, Columbus 43210.; The production of TNF-alpha and TNF-beta by human B-cell lines was studied at both the molecular and biological levels. The 24 B-cell lines studied included EBV+ cell lines (n = 13), EBV- cell lines (n = 8), and AIDS-associated B-cell lines (AABCL) (n = 3) which are EBV+/HIV-. Whereas radioimmunoprecipitation using TN
Zidovudine for chemoprophylaxis after occupational exposure to HIV-infected blood: an economic evaluation.: Clin Infect Dis. 1992 Apr;14(4):822-30. Unique Identifier : AIDSLINE MED/92247979; Allen UD; Read S; Gafni A; Division of Infectious Diseases, Hospital for Sick Children,; Toronto, Canada.; Three approaches to the management of health care workers (HCWs) following percutaneous exposure to blood of previously unknown serological status were compared using cost-effectiveness analysis. In strategy A, all HCWs are offered zidovudine as soon as possible after exposure. The decision is made within 72 hours to
Pulmonary toxoplasmosis: a review.: Clin Infect Dis. 1992 Apr;14(4):863-70. Unique Identifier : AIDSLINE MED/92247985; Pomeroy C; Filice GA; Infectious Disease Section, Veterans Affairs Medical Center,; Minneapolis, Minnesota 55417.; Toxoplasma pneumonia is being recognized with increased frequency, especially in patients with AIDS. We reviewed the English-, French-, and Spanish-language literature from January 1966 through February 1991 to identify cases of postnatally acquired pneumonia associated with Toxoplasma gondii. We identified two distin
Progression and clinical outcome of infection due to human immunodeficiency virus [see comments]: Clin Infect Dis. 1992 Apr;14(4):966-72. Unique Identifier : AIDSLINE MED/92248004; Lifson AR; Hessol NA; Rutherford GW; Department of Epidemiology and Biostatistics, School of Medicine,; University of California, San Francisco 94143-0560.; Ten years into the AIDS epidemic, how are we doing? Have we managed to significantly alter the course of infection with human immunodeficiency virus (HIV)? Have we defined factors that accelerate or decelerate the rate of progression of infection to clinical disease? Are we better able to predict who is most likely to
Nocardia brasiliensis infection in patients with AIDS [letter] [see comments]: Clin Infect Dis. 1992 Apr;14(4):977-8. Unique Identifier : AIDSLINE MED/92248007; Sieratzki HJ
Radiosensitivity of human immunodeficiency virus type 1 [letter]: Clin Infect Dis. 1992 Apr;14(4):978-9. Unique Identifier : AIDSLINE MED/92248008; Conway B; Tomford WW
[Treatment dropout rate in patients with tuberculosis and HIV infection (letter)]: An Med Interna. 1992 Feb;9(2):101-2. Unique Identifier : AIDSLINE MED/92248032; Gaspar G; Gato A; Ballesteros P; Perez Gomez V
[Pneumocystis carinii pneumonia in AIDS and prolonged fever]: An Med Interna. 1992 Feb;9(2):87-90. Unique Identifier : AIDSLINE MED/92248045; Navarro V; Nieto A; Bernacer B; Borras R; Ferrer C; Seccion de Enfermedades Infecciosas, Hospital General; Universitario de Valencia.; Pneumonia by Pneumocystis carinii (NPC) presents a high incidence in the evolution of patients infected by the human immunodeficiency virus (HIV). Common clinical signs include fever, dry cough and dyspnea, in the presence of pulmonar interstitial affection with several degrees of hypoxemia. One hundred and sixteen pa
[The liver and AIDS]: An Med Interna. 1992 Feb;9(2):91-4. Unique Identifier : AIDSLINE MED/92248046; Rull S; Sanchis MJ; Palacios A; Anguiz A; Colomina J; Servicio de Medicina Interna, Hospital General de Elda (Servicio; Valenciano de Salud), Alicante.; Hepatic disorders in AIDS are very common, although the injuries observed are usually non-specific. This is the reason why the real usefulness of hepatic biopsy in this patients is being currently discussed. In this work, such aspect and the hepatic injuries observed in patients with AIDS are discussed. Current indica
Antibody production in infants born to HIV-1-infected mothers.: Int J Med Microbiol Virol Parasitol Infect Dis. 1992 Feb;276(3):429-36. Unique Identifier : AIDSLINE MED/92248253; Guerra E; von Hunolstein C; Quinti I; Recchia S; Stegagno M; Visconti E; Orefici G; Department of Allergy and Clinical Immunology, University of Rome; La Sapienza, Italy.; Naturally occurring antibodies to polysaccharide antigens of pathogens commonly isolated from HIV-1-infected subjects were analyzed in serially collected sera of children born to seropositive mothers. Purified polysaccharides from type 14 Streptococcus pneumoniae, group C Neisseria meningitidis, type b Haemophilus inf
Prevalence of antibodies to parvovirus B19 in selected groups of patients and healthy individuals.: Int J Med Microbiol Virol Parasitol Infect Dis. 1992 Feb;276(3):437-42. Unique Identifier : AIDSLINE MED/92248254; Schwarz TF; Hottentrager B; Roggendorf M; Max von Pettenkofer-Institut fur Hygiene and Medizinische; Mikrobiologie, Ludwig-Maximilians-Universitat, Munchen.; The prevalence of antibodies to parvovirus B19 in sera (n = 745) of various groups of patients and healthy individuals was determined by the enzyme immunoassay, using viral particles as antigen. Among healthy individuals, anti-B19 IgG prevalence was highest in nurses (65.4% (17/26)); in medical students it was 34.1% (
Bacillary angiomatosis. A new disease with a broadening clinicopathologic spectrum.: Histol Histopathol. 1992 Jan;7(1):143-52. Unique Identifier : AIDSLINE MED/92248274; Tsang WY; Chan JK; Institute of Pathology, Queen Elizabeth Hospital, Hong Kong.; Bacillary angiomatosis (BA) is a reactive vasoproliferative lesion occurring almost exclusively in immunocompromised individuals in response to infection by a bacillus closely related to Rochalimaea quintana. The commonest site of involvement is the skin, in the form of multiple erythematous nodules, but
Attitudes and experiences of human immunodeficiency virus-positive patients to surgery and surgeons.: Br J Surg. 1992 Apr;79(4):333-4. Unique Identifier : AIDSLINE MED/92248406; Gill SK; Emberton M; Scott HJ; Academic Department of Genitourinary Medicine, University College; and Middlesex School of Medicine, Middlesex Hospital, London, UK.; The issues regarding screening and identification of patients at risk for human immunodeficiency virus (HIV) infection before surgery continue to be discussed, and there is a need for information regarding attitudes of both surgeons and patients to this issue. A population of HIV-positive patients attending a genitour
[HTLV-I retroviral variant in Zaire in patient with chronic neuromyelopathy. Nucleotidic sequence of the envelope gene]: C R Acad Sci III. 1992;314(4):159-64. Unique Identifier : AIDSLINE MED/92248462; Gessain A; Boeri E; Kazadi K; Garin B; Salaun JJ; Gallo R; de The G; Franchini G; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institute of Health, Bethesda.; The oncoretrovirus HTLV-I is the etiological agent of adult T cell leukemia (ATL) and tropical spastic paraparesis/HLTV-I associated myelopathy (TSP/HAM). In contrast to the human lentiretroviruses, HIV-I and HIV-2, the causative agents of AIDS, HTLV-I is genetically very stable. We report here the molecular character
Preventing cognitive decline.: Clin Geriatr Med. 1992 Feb;8(1):19-34. Unique Identifier : AIDSLINE MED/92248539; Nolan KA; Blass JP; Altschul Laboratory for Dementia Research, Burke Medical Research; Institute, Cornell University Medical College, White Plains, New; York.; Many studies of age-related cognitive decline have failed to distinguish between usual and successful aging. Although some degree of cognitive impairment is associated with aging, when one looks at average performance, there is great variability among individuals, with many showing little or no deleterious effects of
Antiviral therapy: current concepts and practices.: Clin Microbiol Rev. 1992 Apr;5(2):146-82. Unique Identifier : AIDSLINE MED/92248549; Bean B; Department of Pathology, Humana Hospital-Michael Reese, Chicago,; Illinois 60616.; Drugs capable of inhibiting viruses in vitro were described in the 1950s, but real progress was not made until the 1970s, when agents capable of inhibiting virus-specific enzymes were first identified. The last decade has seen rapid progress in both our understanding of antiviral therapy and the number of antiviral ag
Differentiation patterns of CD4/CD8 thymocyte subsets in cocultures of fetal thymus and lymphohemopoietic cells from c-fos transgenic and normal mice.: Cell Immunol. 1992 May;141(2):279-92. Unique Identifier : AIDSLINE MED/92248709; Fridkis-Hareli M; Abel L; Eisenbach L; Globerson A; Department of Cell Biology, Weizmann Institute of Science,; Rehovot, Israel.; This study examined the involvement of c-fos protooncogene in thymocyte development from lymphohemopoietic T cell progenitors, within the thymic microenvironment. We first analyzed the thymocytes developing in vitro in the fetal thymus from the c-fos transgenic mice and found a high proportion of CD4+ single positive
HIV-1 infection and the acquired immunodeficiency syndrome in children.: Curr Probl Pediatr. 1992 Apr;22(4):166-204; discussion 205. Unique Identifier : AIDSLINE MED/92248996; Indacochea FJ; Scott GB; Division of Pediatric Immunology and Infectious Diseases,; University of Miami School of Medicine, Florida.
Radiology of AIDS in the pediatric patient.: Curr Probl Diagn Radiol. 1992 May-Jun;21(3):79-109. Unique Identifier : AIDSLINE MED/92248997; Grattan-Smith D; Harrison LF; Singleton EB; Department of Radiology, Royal Children's Hospital, Melbourne,; Australia.; The Acquired Immunodeficiency Syndrome (AIDS) has involved the pediatric age group and is especially prevalent in babies born of mothers who are intravenous drug abusers or prostitutes. Approximately 30% of children born to mothers who are seropositive for the human immunodeficiency virus (HIV) will develop HIV infect
Investigation on lymphocyte subpopulations in the intestinal lamina propria in inflammatory bowel diseases.: Chin Med J (Engl). 1992 Jan;105(1):18-24. Unique Identifier : AIDSLINE MED/92249032; Yuan SZ; Foster LP; Wang NS; Kraft SC; Gastrointestinal Research Laboratory, Sun Yat-Sen Memorial; Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou.; Intestinal lamina proprial lymphocytes were enumerated in 13 patients with Crohn s disease (CD), 7 with ulcerative colitis (UC) and 9 control subjects with grossly normal bowel. The percentages and absolute numbers of B cells and complement receptor-bearing lymphocytes in the patients with UC did not differ significan
Transcriptional regulation of the HIV-1 promoter by NF-kappa B in vitro.: Genes Dev. 1992 May;6(5):761-74. Unique Identifier : AIDSLINE MED/92249769; Kretzschmar M; Meisterernst M; Scheidereit C; Li G; Roeder RG; Laboratory of Biochemistry and Molecular Biology, Rockefeller; University, New York, New York 10021.; NF-kappa B, purified from HeLa cell cytosol, and a recombinant p50 subunit of NF-kappa B alone (expressed in and purified from bacteria) both stimulated transcription from the HIV-1 promoter in vitro (at least up to 15-fold). A deletion analysis of the p50 subunit revealed that transcriptional activation was mediated
Disseminated Penicillium marneffei infection in HIV-infected subject.: Histopathology. 1992 Apr;20(4):287-93. Unique Identifier : AIDSLINE MED/92249939; Tsui WM; Ma KF; Tsang DN; Institute of Pathology, Queen Elizabeth Hospital, Hong Kong.; Penicillium marneffei is a rare human pathogen predominantly affecting residents of South-east Asia. We report four fatal cases from Hong Kong in human immunodeficiency virus-infected patients. The diagnosis was established by histo
Hairy leukoplakia [letter; comment]: Histopathology. 1992 Apr;20(4):365. Unique Identifier : AIDSLINE MED/92249952; Lucas S
Complete replacement of membrane cholesterol with 4,4',14-trimethyl sterols in a human T cell line defective in lanosterol demethylation.: J Biol Chem. 1992 May 5;267(13):8819-26. Unique Identifier : AIDSLINE MED/92250464; Buttke TM; Folks TM; Department of Microbiology & Immunology, East Carolina; University, School of Medicine, Greenville, North Carolina; 27858-4354.; A3.01 is a hypoxanthine/aminopterin/thymidine-sensitive, human immunodeficiency virus-susceptible, human T cell line derived by Folks et al. (Folks, T., Benn, S., Rabson, A., Theodore, T., Hoggan, M. D., Martin, M., Lightfoote, M., and Sell, K. (1985) Proc. Natl. Acad. Sci. U.S.A. 82, 4539-4543) following exposure of
Structural implications of spectroscopic characterization of a putative zinc finger peptide from HIV-1 integrase.: J Biol Chem. 1992 May 15;267(14):9639-44. Unique Identifier : AIDSLINE MED/92250614; Burke CJ; Sanyal G; Bruner MW; Ryan JA; LaFemina RL; Robbins HL; Zeft AS; Middaugh CR; Cordingley MG; Department of Pharmaceutical Research, Merck Research; Laboratories, West Point, Pennsylvania 19486.; The N-terminal domain of human immunodeficiency virus (HIV-1) integrase (IN) contains the sequence motif His-Xaa3-His-Xaa23-Cys-Xaa2-Cys, which is strongly conserved in all retroviral and retrotransposon IN proteins. This structural motif constitutes a putative zinc finger in which a metal ion may be coordinately boun
Cognitive dysfunction in an HIV-infected patient.: Hosp Pract (Off Ed). 1992 May 15;27(5):91-9, discussion 99-100. Unique Identifier : AIDSLINE MED/92250769; Singer EJ; University of California, Los Angeles.
[The kinetic changes in murine lymphocyte subsets in regenerating liver]: Nippon Ika Daigaku Zasshi. 1992 Apr;59(2):166-75. Unique Identifier : AIDSLINE MED/92250800; Hirano F; Sakamoto T; Miki M; Yokomuro K; Department of Microbiology and Immunology, Nippon Medical School,; Tokyo, Japan.; The regeneration of the liver is frequently observed after the resection of liver tumor and partial liver transplantation, and it is assumed that the modification of the hematolymphoid system in the liver will occur during this process and influence not only the progress of the primary disease but also liver regenerat
Rapid differentiation of Mycobacterium xenopi from mycobacteria of the Mycobacterium avium-intracellulare complex by pyrolysis mass spectrometry.: J Clin Pathol. 1992 Apr;45(4):355-7. Unique Identifier : AIDSLINE MED/92250928; Sisson PR; Freeman R; Magee JG; Lightfoot NF; Regional Public Health Laboratory, General Hospital, Newcastle; upon Tyne.; Thirty four cultures of slow growing, Tween-80 negative mycobacteria were analysed by pyrolysis mass spectrometry. The results showed that pyrolysis mass spectrometry could positively distinguish strains of Mycobacterium xenopi from those of the Mycobacterium avium-intracellulare (MAI) complex. Pyrolysis mass spectrom
Bovine mononuclear leukocyte subpopulations in peripheral blood and mammary gland secretions during lactation.: J Dairy Sci. 1992 Apr;75(4):998-1006. Unique Identifier : AIDSLINE MED/92251008; Park YH; Fox LK; Hamilton MJ; Davis WC; Department of Veterinary Microbiology and Pathology, Washington; State University, Pullman 99164.; Florescence flow cytometry and monoclonal antibodies were used to analyze the composition of leukocytes from peripheral blood and mammary gland secretions. Samples were obtained from Holstein dairy cows, free of IMI, at six time points during the lactation cycle. The percentage of monocytes in peripheral blood mononuc
Preferred sources of information on AIDS among high school students from selected schools in Zimbabwe.: J Adv Nurs. 1992 Apr;17(4):507-13. Unique Identifier : AIDSLINE MED/92251044; Ndlovu RJ; Sihlangu RH; Department of Nursing Science, Faculty of Medicine, University of; Zimbabwe.; Following various national HIV and AIDS awareness campaign activities under the auspices of the Ministries of Health and Education, Zimbabwe , an AIDS KABP survey was undertaken. The study sample comprised 478 high school students randomly selected and stratified to represent sex
Impact of human immunodeficiency virus infection on women and infants.: Infect Dis Clin North Am. 1992 Mar;6(1):1-17. Unique Identifier : AIDSLINE MED/92251105; Kline MW; Shearer WT; Department of Pediatrics, Baylor College of Medicine, Houston,; Texas.; Infection with HIV is a problem of growing magnitude among women and children in the United States . During 1991, AIDS will be among the five leading causes of death for women of childbearing age. Over 80% of children with HIV have acquired the infection vertically, and AIDS is now a le
Immunoglobulin therapy in older infants and children.: Infect Dis Clin North Am. 1992 Mar;6(1):97-116. Unique Identifier : AIDSLINE MED/92251121; Fischer GW; Department of Pediatrics, F. Edward Hebert School of Medicine,; Uniformed Services University of the Health Sciences, Bethesda,; Maryland.; The availability of intravenous immunoglobulin preparations and human monoclonal antibodies has broadened the potential utility of antibody therapy to include treatment of viral infections such as cytomegalovirus and respiratory syncytial virus and prevention and treatment of serio
Prevalence of four blood-borne viruses (HBV, HCV, HTLV-I, HIV-1) among haemodialysis patients in Japan.: J Med Virol. 1992 Apr;36(4):271-3. Unique Identifier : AIDSLINE MED/92251340; Tamura I; Koda T; Kobayashi Y; Ichimura H; Kurimura O; Kurimura T; Institute of Clinical Research, Kure National Hospital, Japan.; To investigate the prevalence of four blood-borne viruses among a cohort of haemodialysis (HD) patients in Japan , hepatitis B surface antigen (HBsAg), antibody to hepatitis C virus (anti-HCV), antibody to human T-cell lymphotropic virus type-I (anti-HTLV-I), and antibody to human im
Serologic differentiation of human T lymphotropic virus type I from type II infection by synthetic peptide immunoassays.: J Med Virol. 1992 Apr;36(4):298-302. Unique Identifier : AIDSLINE MED/92251345; Roberts CR; Mitra R; Hyams K; Brodine SK; Lal RB; Department of Diagnostic Retrovirology, Walter Reed Army; Institute of Research, Washington, D.C.; Synthetic peptide-based serologic assays (Select-HTLV and SynthEIA) that distinguish the closely related human T-cell lymphotropic virus types I (HTLV-I) and II (HTLV-II) were tested blindly for their ability to correctly identify infection caused by either virus type. Of 57 HTLV-I and 38 HTLV-II specimens from indivi
Antibody titers to HTLV-I-p40tax protein and gag-env hybrid protein in HTLV-I-associated myelopathy/tropical spastic paraparesis: correlation with increased HTLV-I proviral DNA load.: J Neurol Sci. 1992 Jan;107(1):98-104. Unique Identifier : AIDSLINE MED/92251382; Kira J; Nakamura M; Sawada T; Koyanagi Y; Ohori N; Itoyama Y; Yamamoto N; Sakaki Y; Goto I; Department of Neurology, Kyushu University, Fukuoka, Japan.; We studied the relationship between antibody titers to recombinant HTLV-I p40tax protein and gag-env hybrid protein in serum (by an enzyme-linked immunosorbent assay) and HTLV-I proviral DNA load in peripheral blood mononuclear cells (by a quantitative polymerase chain reaction method) in 18 patients with HTLV-I-assoc
Implementing an infection control program for the community-based healthcare facility.: J Nurs Adm. 1992 May;22(5):18-22. Unique Identifier : AIDSLINE MED/92251488; Rice R; Jorden JU; Barnes College, St. Louis, MO.; With the rampant increase in patients with communicable diseases, including AIDS and Hepatitis B, a sound infection control program is vital. Focusing on the needs of administrators in community healthcare agencies such as home health agencies, long-term care facilities, and public health departments, the authors disc
States cautious on HIV testing [news]: J Nurs Adm. 1992 May;22(5):4. Unique Identifier : AIDSLINE MED/92251492
HIV-infected woman. Illness cognition assessment.: J Psychosoc Nurs Ment Health Serv. 1992 Feb;30(2):11-5. Unique Identifier : AIDSLINE MED/92251709; Regan-Kubinski MJ; Sharts-Engel N; 1. Special attention is particularly important in addressing the mental health needs of HIV-infected women. These needs may involve issues such as concerns about present or future pregnancy; child-rearing, often as single parents; poverty, illicit drug use or addiction; and the potential lack of support services. 2. D
New evidence links cocaine use and HIV [news]: J Psychosoc Nurs Ment Health Serv. 1992 Mar;30(3):45. Unique Identifier : AIDSLINE MED/92251724
Intra-operative injury and military surgeons.: J R Army Med Corps. 1992 Feb;138(1):36-7. Unique Identifier : AIDSLINE MED/92251731; Lovell ME; 208 General Hospital, TA Centre, Liverpool.
Behavioral change through empowerment: prevention of AIDS [editorial]: J Natl Med Assoc. 1992 Mar;84(3):225-8. Unique Identifier : AIDSLINE MED/92251814; Ting D; Carter JH
Hormone pattern in pharmacologically feminized male transsexuals in the California State prison system.: J Natl Med Assoc. 1992 Mar;84(3):241-50. Unique Identifier : AIDSLINE MED/92251817; Valenta LJ; Elias AN; Domurat ES; Patton State Hospital, Department of Mental Health, State of; California.; The hormonal profile of 40 transsexual inmates from a pool of 86 inmates in the California State prison system was studied before and after therapy with feminizing hormones. Clinical and social data were obtained on all 86 inmates; the incidence of human immunodeficiency virus (HIV) seropositivity was examined in 76 o
The effect of changing the definition of AIDS on the modeling of AIDS [letter]: JAMA. 1992 May 27;267(20):2737-8. Unique Identifier : AIDSLINE MED/92251927; Hoover DR; Taylor JM; Black CA; Munoz A; Saah AJ; Chmiel JS; Kingsley L
Human immunodeficiency virus type 2 infection in the United States. Epidemiology, diagnosis, and public health implications.: JAMA. 1992 May 27;267(20):2775-9. Unique Identifier : AIDSLINE MED/92251940; O'Brien TR; George JR; Holmberg SD; Division of HIV/AIDS, Centers for Disease Control, Atlanta, GA; 30333.
[Detection of HTLV-ImRNA by in situ hybridization technique using biotinylated oligonucleotide probe]: Rinsho Ketsueki. 1992 Mar;33(3):311-6. Unique Identifier : AIDSLINE MED/92251988; Hirose S; Transfusion Center, Kochi Medical School.; The expressions of human T-lymphotropic virus type I (HTLV-I) mRNA in the HTLV-I-infected lymphocytes were studied in the peripheral blood of two HTLV-I carriers and of three patients with adult T-cell leukemia (ATL) (acute, chronic and lymphoma types) by in situ hybridization technique using two biotinylated single-s
Human immunodeficiency virus associated anemia.: Med Clin North Am. 1992 May;76(3):699-709. Unique Identifier : AIDSLINE MED/92252448; Doukas MA; Lucille P. Markey Cancer Center, University of Kentucky,; Lexington.; Anemia in HIV-infected patients is often overshadowed by other disorders associated with this viral disease, but it can markedly contribute to morbidity and limit antiviral therapy. Evaluation of this patient population is difficult because of the probability of a multifactorial etiology and spurious laboratory indica
Use of blood transfusion in management of anemia.: Med Clin North Am. 1992 May;76(3):727-44. Unique Identifier : AIDSLINE MED/92252450; Jain R; Hematology-Oncology Section, Salem Veterans Administration; Medical Center, Virginia.; Transfusion of red blood cells is useful in restoring oxygen-carrying capacity in patients with symptomatic anemia. In general, physicians should avoid transfusing blood based on hemoglobin concentration alone. Instead, they should focus on the impact of anemia on the patient s symptoms and level of activity. The conc
[Testing all pregnant women in Sweden for HIV is not meaningful]: Lakartidningen. 1992 Apr 1;89(14):1158. Unique Identifier : AIDSLINE MED/92252457; Eitrem R; Liljestrand J; Smittskyddslakare, Landstinget Blekinge.
[Compulsory isolation of HIV-positive patients in practice]: Lakartidningen. 1992 Apr 1;89(14):1187-8. Unique Identifier : AIDSLINE MED/92252466; Christenson B; Lundbergh P; Karolinska sjukhuset, Stockholm.
Update: investigations of patients who have been treated by HIV-infected health-care workers.: MMWR Morb Mortal Wkly Rep. 1992 May 15;41(19):344-6. Unique Identifier : AIDSLINE MED/92252819; Investigation of the patients of a Florida dentist with acquired immunodeficiency syndrome (AIDS) concluded that human immunodeficiency virus (HIV) was transmitted to five (0.5%) of approximately 1100 patients who were evaluated (1-3). Although the precise events resulting in transmission of HIV to these patients are
Risky business [see comments]: N Engl J Med. 1992 Jun 4;326(23):1546-9. Unique Identifier : AIDSLINE MED/92252877; Pauker SG; Kopelman RI; Division of Clinical Decision Making, New England Medical Center,; Tufts University School of Medicine, Boston.
H. influenzae vaccines in HIV [letter; comment]: N Engl J Med. 1992 Jun 4;326(23):1569; discussion 1570-1. Unique Identifier : AIDSLINE MED/92252887; Hecht FM
H. influenzae vaccines in HIV [letter; comment]: N Engl J Med. 1992 Jun 4;326(23):1569-70; discussion 1570-1. Unique Identifier : AIDSLINE MED/92252888; Ranki A; Leinikki P; Krohn K; Sarna S; Valle SL
Plasma concentrations of zidovudine [letter]: N Engl J Med. 1992 Jun 4;326(23):1571. Unique Identifier : AIDSLINE MED/92252889; Escolano S; Mentre F; Golmard JL; Diquet B; Mallet A
Central pain from cerebral abscess: thalamic syndrome in AIDS patients with toxoplasmosis [see comments]: Neurology. 1992 May;42(5):1107-9. Unique Identifier : AIDSLINE MED/92253033; Gonzales GR; Herskovitz S; Rosenblum M; Foley KM; Kanner R; Brown A; Portenoy RK; Department of Neurology, University of Cincinnati, OH.; We describe two patients with acquired immunodeficiency syndrome (AIDS) who developed classic thalamic syndrome (TS) due to Toxoplasma abscesses in the thalamic region. Treatment with amitriptyline provided substantial relief in both patients. Postmortem examination in one case revealed a lesion in the internal capsul
The ethical role of neurologists in the AIDS epidemic. Report of the Ethics and Humanities Subcommittee of the American Academy of Neurology.: Neurology. 1992 May;42(5):1116-7. Unique Identifier : AIDSLINE MED/92253035
Cellular antioxidant status and human immunodeficiency virus replication [see comments]: Nutr Rev. 1992 Jan;50(1):15-8. Unique Identifier : AIDSLINE MED/92253101; Baker DH; Wood RJ; Department of Animal Sciences, University of Illinois, Urbana; 61801.; The factors that stimulate replication of the human immunodeficiency virus (HIV) and determine the period of disease latency are poorly understood. Recent evidence from in vitro cell culture studies of HIV-infected cells suggest that HIV activity is profoundly affected by the presence of antioxidants, such as glutathi
The impact of human immunodeficiency virus serostatus on reproductive decisions of women.: Obstet Gynecol. 1992 Jun;79(6):1027-31. Unique Identifier : AIDSLINE MED/92253141; Sunderland A; Minkoff HL; Handte J; Moroso G; Landesman S; Department of Internal Medicine, State University of New York; Health Science Center, Brooklyn.; Each year in the United States , several thousand women infected with the human immunodeficiency virus (HIV) become pregnant. The scope of the pediatric HIV epidemic will be determined by the reproductive decisions of these women. Although initial studies have not documented an effect o
School placement for human immunodeficiency virus-infected children: the Baltimore City experience.: Pediatrics. 1992 May;89(5 Pt 1):843-8. Unique Identifier : AIDSLINE MED/92253278; Santelli JS; Birn AE; Linde J; Baltimore City Health Department, MD.; Over the past 6 years, the city of Baltimore has successfully implemented a school placement policy for human immunodeficiency virus (HIV)-infected children and children with acquired immunodeficiency syndrome (AIDS). Both policy and specific procedures are based on nationally promulgated guidelines. School placement
Guidelines for cardiac monitoring of children during and after anthracycline therapy: report of the Cardiology Committee of the Childrens Cancer Study Group.: Pediatrics. 1992 May;89(5 Pt 1):942-9. Unique Identifier : AIDSLINE MED/92253297; Steinherz LJ; Graham T; Hurwitz R; Sondheimer HM; Schwartz RG; Shaffer EM; Sandor G; Benson L; Williams R; Memorial Sloan-Kettering Cancer Center, New York, NY.; The anthracycline antibiotics, daunorubicin, doxorubicin, and the newer derivatives, are important components of many antineoplastic chemotherapeutic regimens. Their usefulness is limited by their cardiotoxicity. Sequential monitoring of cardiac function of patients undergoing chemotherapy allows identification of sub
Changes in acquired immunodeficiency syndrome-related risk behavior after adolescence: relationships to knowledge and experience concerning human immunodeficiency virus infection.: Pediatrics. 1992 May;89(5 Pt 1):950-6. Unique Identifier : AIDSLINE MED/92253298; Stiffman AR; Earls F; Dore P; Cunningham R; George Warren Brown School of Social Work, Washington University,; St Louis, MO 63130.; This paper explores the extent of change in acquired immunodeficiency syndrome (AIDS) risk level and in the numbers of AIDS-related risk behaviors in 602 inner-city adolescents as they enter young adulthood. Youths risk level for human immunodeficiency virus (HIV) infection during adolescence was categorized as high
Prevention of pre-PCR mis-priming and primer dimerization improves low-copy-number amplifications.: Nucleic Acids Res. 1992 Apr 11;20(7):1717-23. Unique Identifier : AIDSLINE MED/92253375; Chou Q; Russell M; Birch DE; Raymond J; Bloch W; Cetus Corporation, Emeryville, CA 94608.; A Hot Start Polymerase Chain Reaction (PCR) entails the withholding of at least one reagent from the reaction mixture until the reaction tube temperature has reached 60-80 degrees C. Hot Start amplification with an AmpliWax vapor barrier uses a layer of solid wax to separate the retained reagent(s) and the test sample
Neuroscience findings in AIDS: a review of research sponsored by the National Institute of Mental Health.: Prog Neuropsychopharmacol Biol Psychiatry. 1992 Mar;16(2):145-70. Unique Identifier : AIDSLINE MED/92253686; Pequegnat W; Garrick NA; Stover E; Office of AIDS Programs, NIMH, Rockville, MD.; 1. The human immunodeficiency virus (HIV-1) infects cells in both the immune system and the brain, but these effects are not independent. 2. Research funded by the National Institute of Mental Health (NIMH) has been directed at identifying some of the mechanisms by which HIV-1 infects the brain, produces pathology, ca
[Sonographic findings in AIDS. Our experience with 125 patients]: Radiol Med (Torino). 1992 Mar;83(3):192-200. Unique Identifier : AIDSLINE MED/92253732; Carreri AL; Cepich MS; Dognini L; Seddio C; Stellini R; Allegri R; Cattedra di Radiologia, Universita, Brescia.; The US findings of 125 patients with the Acquired Immunodeficiency Syndrome (AIDS) were retrospectively reviewed in order to assess the effective role of the method in the study of this disease. US findings are reported organ by organ: a few of them appear to be exclusively related to HIV infection (opportunistic infe
[The hypereosinophilia syndrome in an HIV+ patient (letter)]: Rev Clin Esp. 1992 Mar;190(5):278. Unique Identifier : AIDSLINE MED/92253785; Carbonell Rabanal MA; Alonso Pacheco ML; Caballero Herraez P; Rodriguez Zapata M
[Renal tubular acidosis due to cotrimoxazole in a patient with AIDS and P. carinii pneumonia (letter)]: Rev Clin Esp. 1992 Mar;190(5):281. Unique Identifier : AIDSLINE MED/92253789; Romeu J; Bertran X; Vilageliu M; Sirera G
Local immune components in chronic obstructive pulmonary disease.: Respiration. 1992;59 Suppl 1:17-9. Unique Identifier : AIDSLINE MED/92253855; Costabel U; Maier K; Teschler H; Wang YM; Abteilung Pneumologie/Allergologie, Ruhrlandklinik, Essen, FRG.; Bronchoalveolar lavage (BAL) may have a potential role in contributing to a more precise definition of COPD disorders, but at present little is known about the cellular and biochemical changes that occur in BAL in the different stages of COPD. On the contrary, BAL features due to smoking habits, a well-known risk fact
BAL modifications after antiblastic and immunomodulant therapy in lung cancer.: Respiration. 1992;59 Suppl 1:50-2. Unique Identifier : AIDSLINE MED/92253866; Capelli O; Rovatti E; Gilioli F; Garuti GC; Lega M; De Maria D; Covi M; Capitolo S; Fontana A; Pellegrino M; et al; Department of Physiology and Pulmonary Diseases, University of; Modena, Italy.; The bronchoalveolar compartment can be easily investigated with BAL (bronchoalveolar lavage) before and after antiblastic therapy. We studied 50 patients affected by primary lung cancer, of whom 31 served as a control group and 19 were submitted to BAL after chemo- and/or radiotherapy. Data from BAL performed in an un
Sleep disturbances in men with asymptomatic human immunodeficiency (HIV) infection.: Sleep. 1992 Apr;15(2):150-5. Unique Identifier : AIDSLINE MED/92253940; Norman SE; Chediak AD; Freeman C; Kiel M; Mendez A; Duncan R; Simoneau J; Nolan B; Sleep Disorders Center, University of Miami School of Medicine,; Mount Sinai Medical Center, Miami Beach, Florida 33140.; During the clinical latency phase of human immunodeficiency virus (HIV) disease the central nervous system may be infected and begin to manifest subtle dysfunction. Our early investigations demonstrated persistent alterations in the sleep architecture of HIV-infected asymptomatic men. The major aims of this study were
HIV associated risk factors: a survey of a troubled adolescent population.: S D J Med. 1992 Apr;45(4):91-4. Unique Identifier : AIDSLINE MED/92254037; Loecker G; Smith DA; Smith L; Bunger P; USD School of Medicine.; The incidence of Acquired Immunodeficiency Syndrome (AIDS) in young adults and the typical incubation period for AIDS suggest that exposure to this disease often occurs in adolescence, a period of life during which risk taking behavior is particularly common. The population of adolescents with mental or behavioral pro
[HIV transmission in heterologous insemination?]: Ugeskr Laeger. 1992 Mar 30;154(14):942-3. Unique Identifier : AIDSLINE MED/92254279
[Diagnosis of HIV-1 infection (letter)]: Ugeskr Laeger. 1992 Mar 30;154(14):943. Unique Identifier : AIDSLINE MED/92254280; Vestergaard BF; Nielsen C
Interviews with anti-HIV-positive individuals detected through the systematic screening of blood donations: consequences on predonation medical interview.: Vox Sang. 1992;62(1):25-8. Unique Identifier : AIDSLINE MED/92254381; Lefrere JJ; Elghouzzi MH; Paquez F; N'Dalla J; Nubel L; Fondation Nationale de Transfusion Sanguine, Paris, France.; This study is based upon interviews with 74 individuals found to be human immunodeficiency virus (HIV)-seropositive through the screening of blood donations between January 1988 and December 1990. The donation history and the risk factor of HIV infection were established. Questions about the use of blood donation as a
Reversal of the decline in the incidence of tuberculosis in the Austrian Tyrol and Vorarlberg in 1989.: Wien Klin Wochenschr. 1992;104(6):158-62. Unique Identifier : AIDSLINE MED/92254418; Fille M; Allerberger F; Zangerle R; Dierich MP; Bundesstaatliche bakeriologisch-serologische; Untersuchungsanstalt, Innsbruck.; The incidence of tuberculosis in the Austrian Tyrol and Vorarlberg has been declining over decades. In 1989 a reversal in this trend was observed. The number of initial isolates of Mycobacterium tuberculosis at the Federal Public Health Laboratory in Innsbruck increased by 2.2% in 1990 (137 strains), as compared with
SMS Board of Directors adopts new guidelines on HIV-infected health care workers.: Wis Med J. 1992 Feb;91(2):95-6. Unique Identifier : AIDSLINE MED/92254435
Properties of nine continuous B-cell lines established from enzootic bovine leukosis tumors.: Zentralbl Veterinarmed [B]. 1992 Feb;39(1):32-8. Unique Identifier : AIDSLINE MED/92254526; Koyama H; Hohdatsu T; Satake M; Kobayashi M; Ashizawa T; Sugimoto K; Yoshikawa H; Okada K; Yoshikawa T; Saito H; Department of Veterinary Infectious Diseases, School of; Veterinary Medicine and Animal Sciences, Kitasato University,; Aomori, Japan.; We established 9 cell lines from 63 tumor cases of enzootic bovine leukosis and studied their properties. Cells of all lines formed small clumps and floated in culture medium, indicating growth. Four of the 9 cell lines were surface immunoglobulin (SIg)-positive, but the remaining 5 line cells were negative for SIg or
Aspiration cytology of lymphocyte-depleted Hodgkin's lymphoma in a man infected with the human immunodeficiency virus. A case report.: Acta Cytol. 1992 May-Jun;36(3):395-8. Unique Identifier : AIDSLINE MED/92254556; Kragel PJ; Miller LK; Casafrancisco D; Department of Pathology, University of Missouri-Kansas City,; Truman Medical Center 64108.; We describe the case of a 39-year-old, human immunodeficiency virus (HIV)-positive man who was noted to have a chest wall mass on physical examination. Fine needle aspiration of the mass showed atypical spindle cells. Excisional biopsy of the mass revealed Hodgkin s lymphoma with areas of lymphocyte depletion consisti
Cytology of extrapulmonary Pneumocystis carinii infection in the acquired immunodeficiency syndrome.: Acta Cytol. 1992 May-Jun;36(3):440-4. Unique Identifier : AIDSLINE MED/92254566; Abati AD; Opitz L; Brones C; Burstein DE; Gallo L; Department of Pathology, New York University Medical Center, New; York 10016.; Rare cases of extrapulmonary Pneumocystis carinii (EPPC) have been seen in patients with acquired immunodeficiency syndrome (AIDS). We report seven such diagnoses of nonpulmonary P carinii (PC) from four AIDS patients between 1986 and 1989. The specimens included fine needle aspirate of liver, spleen, periarticular ti
Self-reported HIV and AIDS experience, practices, and knowledge of Pennsylvania family physicians.: J Am Board Fam Pract. 1992 May-Jun;5(3):249-55. Unique Identifier : AIDSLINE MED/92254640; Jones RL; Samkoff JS; Jacques CH; Hamory BH; Spotts DA; Localio R; Department of Family & Community Medicine, Pennsylvania State; University College of Medicine, Milton S. Hershey Medical Center,; Hershey 17033.; BACKGROUND: Patients with disease caused by the human immunodeficiency virus (HIV), while still more commonly treated in urban settings, are being seen in nonurban areas in numbers rapidly outstripping the local availability of specialists with expertise in HIV or acquired immunodeficiency syndrome (AIDS). METHODS: A
Treatment of AIDS and HIV-related conditions: 1992.: J Am Board Fam Pract. 1992 May-Jun;5(3):335-50. Unique Identifier : AIDSLINE MED/92254652; Goldschmidt RH; Dong BJ; Family Practice Residency Program, San Francisco General; Hospital, CA 94110.
Acute Guillain-Barre syndrome associated with asymptomatic HIV infection.: Acta Neurol (Napoli). 1992 Feb;14(1):66-70. Unique Identifier : AIDSLINE MED/92254681; Franciotta DM; Brustia R; Minoli L; Bono G; Ceroni M; Parisi A; Melzi d'Eril G; IRCCS, Istituto Neurologico, Fondazione C. Mondino, Universita; Degli Studi, Pavia.; A 25-year-old male drug addict presented with a rapidly progressive ascending tetraplegia, requiring assisted ventilation. One month earlier he had fever (40 degrees C) and asthenia. Cerebrospinal fluid (CSF) examination showed elevated albumin level and albuminocytologic dissociation. HIV testing was positive in both
Interactions between persons at risk for AIDS and the general population in Denmark.: Am J Epidemiol. 1992 Mar 15;135(6):593-602. Unique Identifier : AIDSLINE MED/92254787; Melbye M; Biggar RJ; Department of Epidemiology, State Serum Institute, Copenhagen,; Denmark.; A nationwide study of sexual behavior was undertaken among 4,680 randomly selected Danes aged 18-59 years. The median number of sexual partners (lifetime) was highest for men aged 30-34 years (eight partners) and for women aged 25-29 years (seven partners). After adjustment for age and sex, having had greater than or
Compliance with zidovudine therapy in patients infected with human immunodeficiency virus, type 1: a cross-sectional study in a municipal hospital clinic.: Am J Med. 1992 May;92(5):495-502. Unique Identifier : AIDSLINE MED/92254883; Samet JH; Libman H; Steger KA; Dhawan RK; Chen J; Shevitz AH; Dewees-Dunk R; Levenson S; Kufe D; Craven DE; Department of Medicine, Boston University School of Medicine,; Massachusetts.; PURPOSE: To determine the extent of and clinical variables associated with zidovudine compliance. PATIENTS AND METHODS: A survey of 83 patients infected with human immunodeficiency virus (HIV) followed in a municipal hospital clinic was performed. Compliance histories were validated by serum and urine zidovudine level
Occupational exposure to human immunodeficiency virus and hepatitis B virus: a comparative analysis of risk.: Am J Med. 1992 May;92(5):503-12. Unique Identifier : AIDSLINE MED/92254884; Owens DK; Nease RF Jr; Department of Veterans Affairs Medical Center, Palo Alto, CA.; OBJECTIVE: To estimate the occupational risk from infection with the human immunodeficiency virus (HIV) in terms of loss of (quality-adjusted) life expectancy, and to compare that risk to those posed by other hazards faced by health care workers. DESIGN: Decision-analytic model. RESULTS: For a 30-year-old female healt
Response of HIV-1-associated polymyositis to intravenous immunoglobulin [letter]: Am J Med. 1992 May;92(5):580-1. Unique Identifier : AIDSLINE MED/92254899; Viard JP; Vittecoq D; Lacroix C; Bach JF
A comparison of retrieval effectiveness for three methods of indexing medical literature.: Am J Med Sci. 1992 May;303(5):292-300. Unique Identifier : AIDSLINE MED/92254904; Hersh WR; Hickam DH; Biomedical Information Communication Center, Oregon Health; Sciences University, Portland 97201.; Conventional approaches to indexing medical literature include the human assignment of terms from a controlled vocabulary, such as MeSH, or the computer assignment of all words in the title and abstract as indexing terms. Human indexing suffers from inconsistency, while word-based indexing suffers from the multiple me
A new drug (566C80) for the treatment of Pneumocystis carinii pneumonia [editorial]: Ann Intern Med. 1992 Jun 1;116(11):953-4. Unique Identifier : AIDSLINE MED/92255105; Hughes WT
Immunologic aspects of schistosomiasis.: Annu Rev Med. 1992;43:209-18. Unique Identifier : AIDSLINE MED/92255284; Capron A; Dessaint JP; Centre d'Immunologie et de Biologie Parasitaire, Unite Mixte; INSERM Ul 67-CNRS 624, Institut Pasteur, Lille, France.; Immunity to schistosomes, helminth worms that infect 200 million people, is targeted to invading larvae (concomitant immunity). In vitro studies have revealed the role of T cells and of particular antibody isotypes in immune defense: IgE antibody cooperates with mononuclear phagocytes, eosinophils, and platelets to ki
Molecular and cellular targeting in the expression of foreign polypeptides in bacteria.: Antonie Van Leeuwenhoek. 1992 Feb;61(2):143-52. Unique Identifier : AIDSLINE MED/92255321; Clement JM; Charbit A; Leclerc C; Martineau P; Muir S; O'Callaghan D; Popescu O; Szmelcman S; Hofnung M; Unite de Programmation Moleculaire and Toxicologie Genetique,; CNRS URA 1444, Paris, France.
AIDS newsletters offer needed advice [news]: AORN J. 1992 May;55(5):1158. Unique Identifier : AIDSLINE MED/92255328
AIDS issues, health insurance reform top state legislative agenda.: AORN J. 1992 May;55(5):1261-72. Unique Identifier : AIDSLINE MED/92255337
[Analysis of lymphocyte surface markers in childhood acute lymphoblastic leukemia during maintenance chemotherapy]: Gan To Kagaku Ryoho. 1992 May;19(5):659-64. Unique Identifier : AIDSLINE MED/92255352; Sugita K; Kurosawa H; Sakakibara H; Eguchi M; Furukawa T; Second Dept. of Pediatrics, Dokkyo University, School of; Medicine, Tochigi, Japan.; In this study we investigated T-cell subsets, HLA-DR and IL2 receptor (IL2R, CD25) expression on T-cells in peripheral blood lymphocytes from the patients with childhood acute leukemia undergoing maintenance chemotherapy with 6-MP and MTX, and compared them with those in the healthy controls. There were decrease of re
An unusual presentation of secondary syphilis in a patient with human immunodeficiency virus infection. A case report and review of the literature.: Arch Dermatol. 1992 Apr;128(4):530-4. Unique Identifier : AIDSLINE MED/92255379; Glover RA; Piaquadio DJ; Kern S; Cockerell CJ; Department of Dermatology, University of Texas Southwestern; Medical Center, Dallas 75235-9072.; BACKGROUND--Syphilis has been reported to assume unusual clinical appearances and to exhibit unusual courses in patients infected with the human immunodeficiency virus (HIV) type 1. We recently observed a distinct manifestation of syphilis in an HIV-infected patient with features not previously described. OBSERVATIONS
Neonatal BCG immunisation.: Arch Dis Child. 1992 Apr;67(4):473-4. Unique Identifier : AIDSLINE MED/92255394; Clarke A; Rudd P; Children's Centre, Royal United Hospital, Bath.
T cell immunodeficiency in dyskeratosis congenita.: Arch Dis Child. 1992 Apr;67(4):524-6. Unique Identifier : AIDSLINE MED/92255407; Lee BW; Yap HK; Quah TC; Chong A; Seah CC; Department of Paediatrics, National University of Singapore.; Dyskeratosis congenita has been found to be associated with abnormal immune function. In this study we report a patient with this association. He developed Pneumocystis carinii interstitial pneumonia, and impaired cell mediated immunity was confirmed by the presence of depressed lymphoproliferative responses to in vit
Human milk banking at Sorrento Maternity Hospital, Birmingham.: Arch Dis Child. 1992 Apr;67(4):556-9. Unique Identifier : AIDSLINE MED/92255416; Balmer SE; Wharton BA; Milk Bank, Sorrento Maternity Hospital, Birmingham.
Thalidomide in patients with acquired immunodeficiency syndrome [letter] [see comments]: Arch Intern Med. 1992 May;152(5):1089-90. Unique Identifier : AIDSLINE MED/92255442; Bouza E; Munoz P; Diaz MD; Vicente T
Analytic sensitivity and specificity of enzyme immunoassay results in testing for human immunodeficiency virus type 1 antibody [see comments]: Arch Pathol Lab Med. 1992 May;116(5):477-81. Unique Identifier : AIDSLINE MED/92255489; Cross GD; Schalla WO; Hancock JS; Hearn TL; Blumer SO; Taylor RN; Valdiserri RO; Laboratory Practice Assessment Branch, Centers for Disease; Control, US Department of Health and Human Services, Atlanta, Ga; 30333.; In 1986, a performance evaluation program at the Centers for Disease Control was implemented to assess the quality of performance of laboratories testing for human immunodeficiency virus type 1 antibody and to identify problems that occur during the testing process. Laboratories participating in the Centers for Diseas
Human immunodeficiency virus type 1 testing. Implications of kit and laboratory performance [editorial; comment]: Arch Pathol Lab Med. 1992 May;116(5):482-3. Unique Identifier : AIDSLINE MED/92255490; Zuck TF
Otic and ophthalmic pneumocystosis in acquired immunodeficiency syndrome. Report of a case and review of the literature.: Arch Pathol Lab Med. 1992 May;116(5):500-3. Unique Identifier : AIDSLINE MED/92255496; Wasserman L; Haghighi P; Laboratory Service, Veteran's Administration Medical Center, San; Diego, CA.; A case of primary Pneumocystis carinii infection involving the left middle ear of a patient with acquired immunodeficiency syndrome is described, and the literature on the otic and ophthalmic pneumocystosis is reviewed. Otic pneumocystosis typically presents as a unilateral polypoid mass, and it is clinically manifest
The gelatinous bone marrow (serous atrophy) in patients with acquired immunodeficiency syndrome. Evidence of excess sulfated glycosaminoglycan.: Arch Pathol Lab Med. 1992 May;116(5):504-8. Unique Identifier : AIDSLINE MED/92255497; Mehta K; Gascon P; Robboy S; Department of Laboratory Medicine, University of Medicine and; Dentistry of New Jersey, New Jersey Medical School, Newark.; Patients with the acquired immunodeficiency syndrome uniformly exhibit hematologic abnormalities characterized by anemia and/or pancytopenia. In a study of 75 consecutive bone marrow biopsy specimens from patients with acquired immunodeficiency syndrome, 29% exhibited serous atrophy, characterized by marrow hypoplasia
Siderotic cerebral macrophages in the acquired immunodeficiency syndrome.: Arch Pathol Lab Med. 1992 May;116(5):509-16. Unique Identifier : AIDSLINE MED/92255498; Gelman BB; Rodriguez-Wolf MG; Wen J; Kumar S; Campbell GR; Herzog N; Department of Pathology, University of Texas Medical Branch,; Galveston 77550.; Excessive hemosiderin-laden perivascular macrophages have been described in the brains of patients with the acquired immunodeficiency syndrome (AIDS) who underwent autopsy; its meaning remains unclear. In the brains of 53 patients with AIDS who consecutively underwent autopsy, we quantified the abnormality, elucidated
Pseudallescheria boydii infection in the acquired immunodeficiency syndrome.: Arch Pathol Lab Med. 1992 May;116(5):535-6. Unique Identifier : AIDSLINE MED/92255503; Scherr GR; Evans SG; Kiyabu MT; Klatt EC; Department of Laboratories and Pathology, Los Angeles County,; University of Southern California Medical Center 90033.; Pulmonary and renal infection developed in a 44-year-old Hispanic man due to the fungus Pseudallescheria boydii. Pseudallescheria boydii has been associated with cutaneous infection known as mycetoma but occurs very infrequently in extracutaneous sites. To our knowledge, this is the second reported case of P boydii in
Clofazimine crystals in alveolar macrophages from a patient with the acquired immunodeficiency syndrome.: Arch Pathol Lab Med. 1992 May;116(5):541-3. Unique Identifier : AIDSLINE MED/92255506; Sandler ED; Ng VL; Hadley WK; Department of Laboratory Medicine, University of California, San; Francisco.; An induced sputum specimen from a 35-year-old patient with the acquired immunodeficiency syndrome (AIDS) contained numerous bright orange-red needle-shaped crystal inclusions in his alveolar macrophages. Careful questioning revealed that he recently had been treated for 7 months with clofazimine (200 mg/d) for persist
Oral presentation of Kaposi's sarcoma in a patient without severe immunodeficiency.: Arch Pathol Lab Med. 1992 May;116(5):543-5. Unique Identifier : AIDSLINE MED/92255507; Beckstead JH; Department of Pathology, Oregon Health Sciences University,; Portland 97201.; Primary oral Kaposi s sarcoma of the traditional type (non-African, non-acquired immunodeficiency syndrome, nonimmunosuppressed) is a rare disorder. Presentation of this disorder at this site has not been well documented in the surgical pathology literature. This report describes a primary oral Kaposi s sarcoma in an
Neurosyphilis and human immunodeficiency virus type 2 infection [letter]: Arch Neurol. 1992 May;49(5):440. Unique Identifier : AIDSLINE MED/92255550; Savall R; Cabre M; Grifol M
Plasma vitamin B12 level as a potential cofactor in studies of human immunodeficiency virus type 1-related cognitive changes [see comments]: Arch Neurol. 1992 May;49(5):501-6. Unique Identifier : AIDSLINE MED/92255563; Beach RS; Morgan R; Wilkie F; Mantero-Atienza E; Blaney N; Shor-Posner G; Lu Y; Eisdorfer C; Baum MK; Department of Epidemiology and Public Health, Broward General; Medical Center, Fort Lauderdale, FL 33136.; Studies of cognitive function in subjects with human immunodeficiency virus type 1 (HIV-1) infection who remain relatively asymptomatic (ie, Centers for Disease Control stages II and III) have provided widely variable estimates of cognitive impairment. In view of the finding that approximately 25% of asymptomatic HIV-
Orbital lymphoma associated with acquired immunodeficiency syndrome [letter]: Arch Ophthalmol. 1992 May;110(5):610-1. Unique Identifier : AIDSLINE MED/92255584; Turok DI; Meyer DR
Monoclonal large granular lymphocyte proliferation in SLE with HTLV-I seroreactivity [published erratum appears in Aust N Z J Med 1992 Apr;22(2):141]: Aust N Z J Med. 1992 Feb;22(1):54-5. Unique Identifier : AIDSLINE MED/92255666; Marlton P; Taylor K; Elliott S; McCormack J; Mater Misericordiae Hospitals, Brisbane, Qld., Australia.; A 60-year-old part Aboriginal woman was observed to develop severe neutropenia and a large granular lymphocyte (LGL) proliferation five years after the diagnosis of systemic lupus erythematosus (SLE). Monoclonality of the CD3+, CD4-, CD8+ LGL population was confirmed using the novel approach of X-linked restriction fr
Mania and AIDS: a psychodynamic emphasis.: Aust N Z J Psychiatry. 1992 Mar;26(1):111-8. Unique Identifier : AIDSLINE MED/92255699; Vamos MJ; Department of Psychiatry & Behavioural Science, School of; Medicine, University of Auckland, New Zealand.; Two cases of mania in homosexual men with AIDS are presented. Particular emphasis is placed on the psychodynamic and psychosocial factors thought to be aetiologically significant. AIDS is seen both as an example of a terminal illness, and also as creating unique difficulties. It is suggested that integrative rather th
BCG immunization and paediatric HIV infection.: Wkly Epidemiol Rec. 1992 May 1;67(18):129-32. Unique Identifier : AIDSLINE MED/92256158
Lymphoid subsets and prognostic factors in multiple myeloma. Cooperative Group for the Study of Monoclonal Gammopathies.: Br J Haematol. 1992 Mar;80(3):305-9. Unique Identifier : AIDSLINE MED/92256199; San Miguel JF; Gonzalez M; Gascon A; Moro MJ; Hernandez JM; Ortega F; Jimenez R; Guerras L; Romero M; Casanova F; et al; Department of Hematology, Hospital Clinico, Universidad de; Salamanca, Spain.; In a uniform series of 170 untreated myeloma patients (MM) we investigated the distribution of T cell subsets in peripheral blood (PB) and their relationship with the most relevant disease characteristics, including survival. CD4 cells were significantly decreased both in percentage and absolute numbers (P less than 0
Intramuscular anti-D immunoglobulins for home treatment of chronic immune thrombocytopenic purpura.: Br J Haematol. 1992 Mar;80(3):337-40. Unique Identifier : AIDSLINE MED/92256204; Gringeri A; Cattaneo M; Santagostino E; Mannucci PM; A. Bianchi Bonomi Hemophilia, University of Milan, Italy.; To assess the efficacy of home treatment with intramuscular anti-D immunoglobulins (anti-D IgG) in patients with idiopathic or HIV-related chronic immune thrombocytopenic purpura (ITP), we conducted an open label, non-controlled, prospective study with a follow-up of 6 months in 51 consecutive patients with HIV-relate
Immunological studies in HIV seronegative haemophiliacs: relationships to blood product therapy.: Br J Haematol. 1992 Mar;80(3):364-9. Unique Identifier : AIDSLINE MED/92256208; Cuthbert RJ; Ludlam CA; Steel CM; Beatson D; Peutherer JF; Department of Haematology, Royal Infirmary of Edinburgh.; Immunological studies were performed on a group of 44 haemophilia A and 15 haemophilia B patients who were treated exclusively with blood products manufactured by the Scottish National Blood Transfusion Service (SNBTS). All patients were HIV seronegative throughout the study. Of the haemophilia A patients 14 (32%) had
Kaposi's sarcoma associated with adult T-cell leukaemia.: Br J Haematol. 1992 Mar;80(3):411-3. Unique Identifier : AIDSLINE MED/92256217; Ozaki S; Kawachi Y; Sakamoto Y; Uchida T; Sasaki K; Mori M; Setsu K; Department of Internal Medicine, Takamatsu Red Cross Hospital,; Kagawa, Japan.
Use of several second generation serological assays to determine the true prevalence of hepatitis C virus infection in haemophiliacs treated with non-virus inactivated factor VIII and IX concentrates.: Br J Haematol. 1992 Apr;80(4):514-8. Unique Identifier : AIDSLINE MED/92256235; Watson HG; Ludlam CA; Rebus S; Zhang LQ; Peutherer JF; Simmonds P; Department of Haematology, Royal Infirmary, Edinburgh.; To investigate the prevalence of hepatitis C virus infection in two risk groups, stored serum samples from treated haemophiliacs and intravenous drug users were tested for anti-HCV by both anti-C-100 based and second generation ELISAs (Abbott and Ortho) followed by testing in two confirmatory immunoblot assays that in
[Bacterial pneumonia in the acquired immunodeficiency syndrome]: An Med Interna. 1992 Apr;9(4):175-7. Unique Identifier : AIDSLINE MED/92256624; Hernandez-Flix S; Castella J; Puzo C; Ausina V; Rodo M; Mayos M; Cornudella R; Servicio de Aparato Respiratorio, Hospital de la Santa Creu i; Sant Pau, Barcelona.; Sixty five patients with AIDS and clinical and/or radiological evidence of pulmonary infection underwent 78 bronchofibroscopies (BF) with protected brushing and bronchoalveolar washing-out. Out of the 78 BF, bacterial infection was diagnosed in 30 cases and associated opportunistic infection in 12 cases. The 18 cases
[A cerebral infarct associated with cryptococcal meningitis in an AIDS patient (letter)]: An Med Interna. 1992 Apr;9(4):206-7. Unique Identifier : AIDSLINE MED/92256634; Tornero Estebanez C; Paricio Blasco A; Pons Espana E
Preservation of a kinetically originated folding of the cis antirepressor sequence for transport of HIV-1 viral RNA.: Biophys Chem. 1992 Jan;42(1):1-6. Unique Identifier : AIDSLINE MED/92256700; Belinky A; Fernandez A; Department of Chemistry, University of Miami, Coral Gables, FL; 33124.; We compute a metastable secondary structure for the cis antirepressor sequence (CAR) in the viral RNA of human immunodeficiency virus 1 (HIV-1) whose lifetime is long enough to allow for further stabilization by interaction with the ribosomal machinery. The structure emerges as the viral genome RNA is being synthesize
New York frees prisoners dying of AIDS [news]: BMJ. 1992 Apr 11;304(6832):935. Unique Identifier : AIDSLINE MED/92257205; Tanne JH
Aggressive HIV management in San Francisco [news]: Br J Hosp Med. 1992 Apr 1-14;47(7):549. Unique Identifier : AIDSLINE MED/92257271
Ultrasonic findings in visceral Pneumocystis carinii infection in AIDS [letter]: Br J Radiol. 1992 Apr;65(772):354. Unique Identifier : AIDSLINE MED/92257306; Grech P
Re: Bladder dysfunction due to human T-lymphotrophic virus type I associated myelopathy. M. Saito et al. Br. J. Urol., 68, 365-368, 1991 [letter; comment]: Br J Urol. 1992 Apr;69(4):440. Unique Identifier : AIDSLINE MED/92257338; McLoughlin J
AIDS and cancer: common interests, common cause.: Cancer Invest. 1992;10(3):243-5. Unique Identifier : AIDSLINE MED/92257351; Turner S
Genetics of Hodgkin's and non-Hodgkin's lymphoma: a review.: Cancer Invest. 1992;10(3):247-56. Unique Identifier : AIDSLINE MED/92257352; Lynch HT; Marcus JN; Lynch JF; Department of Preventive Medicine/Public Health, Creighton; University School of Medicine, Omaha, Nebraska 68178.; Host susceptibility factors have been documented in both HD and NHL wherein a subset of pedigrees provide evidence for an autosomal dominantly inherited factor. Families with both HD and NHL occurring in genetically informative patients provide evidence in support of a possible common pathogenetic pathway for these di
Triple-helical capture assay for quantification of polymerase chain reaction products.: Clin Chem. 1992 May;38(5):687-94. Unique Identifier : AIDSLINE MED/92257720; Vary CP; Idexx Corp., Portland, ME 04101.; This method for rapid, automated analysis of polymerase chain reaction (PCR) products makes use of PCR primers containing 5 -polypyrimidine sequences. Polypyrimidine-headed primers confer to the PCR product the ability to form triple helical complexes with a third polypyrimidine oligonucleotide. Third-strand oligonucl
Enzyme immunoassay with synthetic peptides to detect anti-HTLV-I antibodies.: Clin Chem. 1992 May;38(5):699-703. Unique Identifier : AIDSLINE MED/92257722; Yamada K; Kuroda N; Washitani Y; Shiraki H; Maeda Y; Central Research Laboratories, Kuraray Co., Ltd., Okayama, Japan.; We developed an enzyme immunoassay (EIA) system to detect antibodies to human T-lymphotropic virus type I (HTLV-I). This system uses chemically synthesized oligopeptides to capture anti-HTLV-I antibodies in serum. The two epitopes of HTLV-I proteins exhibiting the most specific antigen-antibody reaction reside within
The role of fiberoptic bronchoscopy for diagnosis of pulmonary tuberculosis in patients at risk for AIDS [see comments]: Chest. 1992 May;101(5):1211-4. Unique Identifier : AIDSLINE MED/92258112; Miro AM; Gibilara E; Powell S; Kamholz SL; King's County Hospital Center, Brooklyn, NY.; In patients with acquired immunodeficiency syndrome (AIDS)-associated pulmonary Mycobacterium tuberculosis (MTB) (group 1), we analyzed whether the addition of transbronchial biopsy (TBB) and bronchial brushings augmented the diagnostic MTB yield over nonbiopsy sampling. Positive acid-fast bacilli (AFB) smears from co
Bronchoalveolar lavage in immunocompromised patients. Clinical and functional consequences.: Chest. 1992 May;101(5):1215-20. Unique Identifier : AIDSLINE MED/92258113; Verra F; Hmouda H; Rauss A; Lebargy F; Cordonnier C; Bignon J; Lemaire F; Brochard L; Service de Pneumologie, Hopital Henri Mondor, Creteil, France.; Fiberoptic bronchoscopy and bronchoalveolar lavage are major tools in the diagnosis of acute pneumonia in immunocompromised patients. We conducted a prospective study to assess the morbidity associated with this procedure in 14 patients with AIDS and 16 patients with drug-induced immunosuppression. No patient had a Pa
Pseudoepidemic of nontuberculous mycobacteria due to a contaminated bronchoscope cleaning machine. Report of an outbreak and review of the literature.: Chest. 1992 May;101(5):1245-9. Unique Identifier : AIDSLINE MED/92258118; Gubler JG; Salfinger M; von Graevenitz A; Medizinische Klinik, Kantonsspital, Winterthur, Switzerland.; We describe a pseudoepidemic due to nontuberculous mycobacteria contaminating the water tank of a machine used to clean and disinfect fiberoptic endoscopes. Forty-six bronchoscopies performed on 41 patients during a six-month period yielded 16 specimens positive for acid-fast bacilli (AFB). One specimen showed Mycobac
Concurrent bacterial lung infection in patients with AIDS, PCP, and respiratory failure.: Chest. 1992 May;101(5):1399-403. Unique Identifier : AIDSLINE MED/92258144; Peruzzi WT; Shapiro BA; Noskin GA; Currie DL; Skoutelis A; Murphy RL; Cane RD; Blake MJ; Department of Anesthesia, Northwestern Memorial Hospital,; Chicago, Ill 60611.; STUDY OBJECTIVES: To determine and compare the incidence of concurrent bacterial lung infection in intubated and nonintubated patients with the acquired immunodeficiency syndrome (AIDS) and Pneumocystis carinii pneumonia (PCP) requiring medical intensive care unit (MICU) admission for support of their respiratory func
Length of stay and survival after intensive care for severe Pneumocystis carinii pneumonia. A prospective study. California Collaborative Treatment Group.: Chest. 1992 May;101(5):1404-6. Unique Identifier : AIDSLINE MED/92258145; Bozzette SA; Feigal D; Chiu J; Gluckstein D; Kemper C; Sattler F; Division of Infectious Diseases, University of California, San; Diego.; Survival rates for persons receiving intensive care for Pneumocystis carinii pneumonia have improved. However, the utility of prolonged intensive care for patients who do not show initial improvement remains unclear. We assessed survival in a nested cohort study of patients receiving intensive care while participating
Positive Kveim test in patients with coexisting sarcoidosis and human immunodeficiency virus infection.: Chest. 1992 May;101(5):1454-6. Unique Identifier : AIDSLINE MED/92258162; Amin DN; Sperber K; Brown LK; Chusid ED; Teirstein AS; Division of Pulmonary and Critical Care Medicine, Mount Sinai; Medical Center, New York.; We present two cases of sarcoidosis complicated by HIV infection. Each case had a different level of sarcoidosis activity and coexisted with either an AIDS-related infection or a HIV-positive state. Manifestations of sarcoidosis were not apparent in the patient with the AIDS-defining opportunistic infection, but were
Rapid evolution of cardiac tamponade due to bacterial pericarditis in two patients with HIV-1 infection.: Chest. 1992 May;101(5):1461-3. Unique Identifier : AIDSLINE MED/92258166; Karve MM; Murali MR; Shah HM; Phelps KR; Department of Medicine, Kings County Hospital Center, Brooklyn.; We describe two HIV-seropositive patients with acute pneumococcal empyema and pericarditis. Cardiac tamponade evolved rapidly in each patient and was reversed with prompt surgical intervention. In each case, immunologic abnormalities were detected which could have facilitated local spread of infection and progression
Spontaneous pneumothorax in AIDS patients not receiving prophylaxis against Pneumocystis carinii pneumonia [letter]: Chest. 1992 May;101(5):1473-4. Unique Identifier : AIDSLINE MED/92258173; Bagheri K; Truitt TJ; Safirstein BH
Perineal manifestations of HIV infection.: Dis Colon Rectum. 1992 Apr;35(4):310-4. Unique Identifier : AIDSLINE MED/92258258; Orkin BA; Smith LE; Division of Colon and Rectal Surgery, George Washington; University Medical Center, Washington, D.C. 20037.; Individuals who are seropositive for the human immunodeficiency virus (HIV) frequently have disorders affecting the anorectum, yet little has been reported on this subject. We reviewed our initial experience with patients with HIV referred to the Division of Colon and Rectal Surgery. Forty patients (age range, 19-45 y
[Vaccinations in secondary immune defects--indications, vaccination success and complications]: Ergeb Inn Med Kinderheilkd. 1992;60:241-331. Unique Identifier : AIDSLINE MED/92258373; Belohradsky BH; Nissl L; Kinderklinik, Universitat Munchen im Dr. von Haunerschen; Kinderspital, Bundesrepublik Deutschland.
Tumor necrosis factor alpha levels in serum and cerebrospinal fluid of patients with AIDS.: Funct Neurol. 1992 Jan-Feb;7(1):35-8. Unique Identifier : AIDSLINE MED/92258715; Franciotta DM; Melzi d'Eril GL; Bono G; Brustia R; Ruberto G; Pagani I; Neuro-AIDS Unit, IRCCS C. Mondino Foundation, Pavia, Italy.; We used a sensitive enzyme-linked immunosorbent assay technique to measure tumor necrosis factor alpha (TNF alpha) levels in serum and cerebrospinal fluid (CSF) samples from 30 patients infected with human immunodeficiency virus type 1 and from 10 normal controls. We found detectable levels of TNF alpha in 19 of 30 CS
[An epidemic in the USA? Diagnosis of tuberculosis impeded by HIV (news)]: Fortschr Med. 1992 Mar 20;110(8):14. Unique Identifier : AIDSLINE MED/92258807; Kle R
HIV prevalence in patients with sexually transmitted diseases in Yaounde, (Cameroon) in 1989 and 1990: necessity of an STD control programme.: Genitourin Med. 1992 Apr;68(2):117-9. Unique Identifier : AIDSLINE MED/92258832; Zekeng L; Yanga D; Trebucq A; Sokal D; Salla R; Kaptue L; Service National de Lutte Contre le Sida, Yaounde, Cameroon.; OBJECTIVE--To monitor HIV seroprevalence among STD clinic attenders as part of a sentinel surveillance programme. DESIGN--Seroepidemiological survey on randomly selected patients. SETTING--Elig Essono STD clinic, Yaounde; from February 1989 to December 1990. PATIENTS--1161 randomly selected patients. MAIN OUTCOME MEAS
Seventh IUVDT Regional Conference on Sexually Transmitted Diseases, Kuala Lumpur, 5-7 September 1991.: Genitourin Med. 1992 Apr;68(2):139-40. Unique Identifier : AIDSLINE MED/92258837; Robinson AJ; Waugh MA
Protection against AIDS [news]: Int Nurs Rev. 1992 Mar-Apr;39(2):41. Unique Identifier : AIDSLINE MED/92259122
Meeting the new AIDS challenge [news]: Int Nurs Rev. 1992 Mar-Apr;39(2):42. Unique Identifier : AIDSLINE MED/92259123
AIDS education [news]: Int Nurs Rev. 1992 Mar-Apr;39(2):45. Unique Identifier : AIDSLINE MED/92259124
Canada: AIDS consultations to give new educational directions [news]: Int Nurs Rev. 1992 Mar-Apr;39(2):45. Unique Identifier : AIDSLINE MED/92259125
Tumor necrosis factor-alpha in the retina in acquired immune deficiency syndrome.: Invest Ophthalmol Vis Sci. 1992 May;33(6):1829-35. Unique Identifier : AIDSLINE MED/92259145; Hofman FM; Hinton DR; Department of Pathology, University of Southern California School; of Medicine, Los Angeles 90033.; The presence of specific cytokines and the number and distribution of leukocytes were determined in the retinas of patients with acquired immune deficiency syndrome (AIDS). Using immunohistocytochemical techniques, three retinas from patients with AIDS had focal infiltration by T-lymphocytes and macrophages. These spe
HTLV-I uveitis: a distinct clinical entity caused by HTLV-I.: Jpn J Cancer Res. 1992 Mar;83(3):236-9. Unique Identifier : AIDSLINE MED/92259295; Mochizuki M; Watanabe T; Yamaguchi K; Takatsuki K; Yoshimura K; Shirao M; Nakashima S; Mori S; Araki S; Miyata N; Department of Ophthalmology, Kurume University School of; Medicine.; Seroepidemiological, clinical and virological studies were carried out in an HTLV-I endemic area to find out if HTLV-I caused an intraocular inflammatory disorder, uveitis. The seroprevalence in patients with uveitis without defined etiologies (62/175, 35.4%) was significantly higher than that in patients with non-uve
Detection of human immunodeficiency virus type 1 (HIV-1) in urine cell pellets from HIV-1-seropositive individuals.: J Clin Microbiol. 1992 May;30(5):1051-5. Unique Identifier : AIDSLINE MED/92259580; Li JJ; Huang YQ; Poiesz BJ; Zaumetzger-Abbot L; Friedman-Kien AE; Department of Microbiology, New York University Medical Center,; New York 10016.; Fresh urine pellets from human immunodeficiency virus type 1 (HIV-1)-seropositive individuals were examined for the presence of the HIV-1 genomic sequence and gene products. By using the polymerase chain reaction technique, HIV-1 DNA proviral sequences were detected in 53 of 80 (66.25%) fresh urine pellets from HIV-1-
Time course of anti-SL-IV immunoglobulin G antibodies in patients with tuberculosis and tuberculosis-associated AIDS.: J Clin Microbiol. 1992 May;30(5):1089-93. Unique Identifier : AIDSLINE MED/92259588; Martin-Casabona N; Gonzalez Fuente T; Papa F; Rossello Urgell J; Vidal Pla R; Codina Grau G; Ruiz Camps I; Servicio de Microbiologia y Parasitologia, Ciudad Sanitaria; Universitaria Vall d'Hebron, Barcelona, Spain.; Immunoglobulin G (IgG) and IgM antibodies against the SL-IV antigen of Mycobacterium tuberculosis in the sera of patients with tuberculosis with negative serology for human immunodeficiency virus (HIV) infection (TB group; n = 97), patients with tuberculosis with positive serology for HIV infection (TB-HIV group; n =
Use of serum antibody and lysozyme levels for diagnosis of leprosy and tuberculosis.: J Clin Microbiol. 1992 May;30(5):1105-10. Unique Identifier : AIDSLINE MED/92259591; Near KA; Lefford MJ; Department of Immunology and Microbiology, Wayne State University; School of Medicine, Detroit, Michigan 48201.; Active tuberculosis (TB) and leprosy are difficult to diagnose early because there are few organisms to detect and the specific immune response does not distinguish between active and inactive disease. We developed an immunoassay for lysozyme to see whether serum lysozyme levels could be used to identify individuals w
Stability of human immunodeficiency virus type 1 antibodies in whole blood dried on filter paper and stored under various tropical conditions in Kinshasa, Zaire [see comments]: J Clin Microbiol. 1992 May;30(5):1179-82. Unique Identifier : AIDSLINE MED/92259604; Behets F; Kashamuka M; Pappaioanou M; Green TA; Ryder RW; Batter V; George JR; Hannon WH; Quinn TC; Projet SIDA, Kinshasa, Zaire.; The use of whole-blood spots on filter paper for the detection of antibody to human immunodeficiency virus type 1 (HIV-1) was evaluated during a 20-week period under a variety of storage environments simulating the harsh tropical field conditions in Kinshasa, Zaire . During the fir
Niacin-positive Mycobacterium kansasii isolated from immunocompromised patients.: J Clin Microbiol. 1992 May;30(5):1344-6. Unique Identifier : AIDSLINE MED/92259641; Nachamkin I; MacGregor RR; Staneck JL; Tsang AY; Denner JC; Willner M; Barbagallo S; Department of Pathology and Laboratory Medicine, University of; Pennsylvania School of Medicine, Philadelphia 19104.; Niacin-positive Mycobacterium kansasii was isolated from three patients, two with respiratory infections and one with a perirectal abscess. The isolates were phenotypically similar to other strains of M. kansasii, differing only in their ability to produce niacin. This phenotype has been reported only twice in the lit
HIV and contact lens wear [editorial]: J Am Optom Assoc. 1992 Jan;63(1):13-5. Unique Identifier : AIDSLINE MED/92259885; Wilson R
The HIV-infected optometrist [editorial]: J Am Optom Assoc. 1992 Jan;63(1):16-7. Unique Identifier : AIDSLINE MED/92259886; Wilson R
Preventing transmission of infectious diseases including the human immunodeficiency virus in the practice of optometry.: J Am Optom Assoc. 1992 Jan;63(1):18-20. Unique Identifier : AIDSLINE MED/92259887; Tillman T; Klotz SA; Maino JH; VA Medical Center, Kansas City, MO 64188.; The risks of acquisition of infectious diseases including the human immunodeficiency virus--1 (HIV) to practitioners and patients in the practice of optometry is discussed. Measures that reduce the risk of contracting or transmitting HIV and other infectious diseases in optometry are presented. Effective disinfection
Medical management of acquired immune deficiency syndrome patients: a review.: J Am Optom Assoc. 1992 Jan;63(1):35-42. Unique Identifier : AIDSLINE MED/92259890; Harkins T; Herriott KB; VA Medical Center, Kansas City, MO 64128.; Patients with acquired immunodeficiency syndrome (AIDS) may become infected by a number of different opportunistic pathogens. Treatment to control the Human Immune Virus (HIV) and its associated infections can be complex, and the medications required are not commonly used on patients with normal immunity.
Alterations in the course of experimental syphilis associated with concurrent simian immunodeficiency virus infection.: J Infect Dis. 1992 Jun;165(6):1020-5. Unique Identifier : AIDSLINE MED/92259994; Marra CM; Handsfield HH; Kuller L; Morton WR; Lukehart SA; Department of Medicine, University of Washington, Seattle.; Case reports suggest that the course of syphilis is altered in patients infected with human immunodeficiency virus (HIV). To investigate this issue, a model of syphilis in rhesus macaques with and without simian immunodeficiency virus (SIV) was developed. After intradermal inoculation with Treponema pallidum, 2 SIV-in
T lymphocyte subsets during and after pregnancy: analysis in human immunodeficiency virus type 1-infected and -uninfected Malawian mothers.: J Infect Dis. 1992 Jun;165(6):1116-9. Unique Identifier : AIDSLINE MED/92260009; Miotti PG; Liomba G; Dallabetta GA; Hoover DR; Chiphangwi JD; Saah AJ; Department of Epidemiology, Johns Hopkins University School of; Hygiene and Public Health, Baltimore, Maryland.; Flow cytometric studies were done in Malawi on 229 women in their third trimester and 128 women 6 weeks postpartum; both human immunodeficiency virus type 1 (HIV-1)-seropositive and seronegative women demonstrated an increase in the absolute number of CD4 and CD8 lymphocytes betwee
Quantitation of plasma human immunodeficiency virus type 1 RNA by competitive polymerase chain reaction [published erratum appears in J Infect Dis 1993 Apr;167(4):995]: J Infect Dis. 1992 Jun;165(6):1119-23. Unique Identifier : AIDSLINE MED/92260010; Scadden DT; Wang Z; Groopman JE; Division of Hematology/Oncology, New England Deaconess Hospital,; Harvard Medical School, Boston, Massachusetts.; Clinical measures of human immunodeficiency virus (HIV) type 1 activity in vivo are limited and hinder the assessment of antiretroviral therapies. Reported here is a method for quantitating HIV-1 RNA in human plasma using the polymerase chain reaction (PCR). This method uses an internal cRNA standard generated from a
Association of biologic false-positive reactions for syphilis with human immunodeficiency virus infection.: J Infect Dis. 1992 Jun;165(6):1124-6. Unique Identifier : AIDSLINE MED/92260011; Rompalo AM; Cannon RO; Quinn TC; Hook EW 3d; Division of Infectious Diseases, Johns Hopkins University School; of Medicine, Baltimore, Maryland.; The prevalence of biologic false-positive (BFP) reactions for syphilis (reactive rapid plasma reagin [RPR] test, nonreactive fluorescent treponemal antibody absorption [FTA-ABS] test) among patients attending two sexually transmitted disease (STD) clinics was evaluated to assess relationships between BFP reactions and
Antibody responses to a major Pneumocystis carinii antigen in human immunodeficiency virus-infected patients with and without P. carinii pneumonia.: J Infect Dis. 1992 Jun;165(6):1151-5. Unique Identifier : AIDSLINE MED/92260018; Lundgren B; Lundgren JD; Nielsen T; Mathiesen L; Nielsen JO; Kovacs JA; Department of Infectious Diseases, University of Copenhagen,; Hvidovre Hospital, Denmark.; Antibody responses to a major purified human Pneumocystis carinii surface antigen (gp95) were determined by ELISA in human immunodeficiency virus (HIV)-infected patients. Serum IgG directed against gp95 was measured in 129 consecutive HIV-infected patients who underwent bronchoscopy for evaluation of pulmonary symptom
Serum cytokines in toxoplasmosis: increased levels of interferon-gamma in immunocompetent patients with lymphadenopathy but not in AIDS patients with encephalitis [letter]: J Infect Dis. 1992 Jun;165(6):1168-70. Unique Identifier : AIDSLINE MED/92260026; Canessa A; Del Bono V; Miletich F; Pistoia V
Sequence variation of functional HTLV-II tax alleles among isolates from an endemic population: lack of evidence for oncogenic determinant in tax.: J Med Virol. 1992 Feb;36(2):136-41. Unique Identifier : AIDSLINE MED/92260186; Hjelle B; Chaney R; United Blood Services, Albuquerque, New Mexico.; Human T-cell leukemia-lymphoma virus type II (HTLV-II) has been isolated from patients with hairy cell leukemia (HCL). We previously described a population with longstanding endemic HTLV-II infection, and showed that there is no increased risk for HCL in the affected groups. We thus have direct evidence that the endem
Prevalence of antibodies to recombinant virion infectivity factor in the sera of prospectively studied patients with HIV-1 infection.: J Med Virol. 1992 Feb;36(2):142-6. Unique Identifier : AIDSLINE MED/92260187; Schwander S; Braun RW; Kuhn JE; Hufert FT; Kern P; Dietrich M; Wieland U; Department of Clinical Medicine, Bernhard Nocht Institute for; Tropical Medicine, Hamburg, Germany.; Two hundred twenty-four sera were collected from 34 HIV-1 infected patients during an observation period of up to 4.5 years (109 patient years of observation). The sera were tested for the presence of antibodies against the HIV-1 virion infectivity factor (vif) protein. Thirty sera from 6 HIV-1 seronegative individual
Low risk of transmission of the human immunodeficiency virus by a solvent-detergent-treated commercial factor VIII concentrate.: J Med Virol. 1992 Feb;36(2):71-4. Unique Identifier : AIDSLINE MED/92260189; Di Paolantonio T; Mariani G; Ghirardini A; Gringeri A; Mannucci PM; Mastrullo L; De Biasi R; Giustarini G; Morfini M; Schiavoni M; et al; Department of Human Biopathology, University of Rome La Sapienza,; Italy.; A study evaluating the risk of a commercial factor VIII (FVIII) concentrate s transmitting the human immunodeficiency virus (HIV) was carried out on hemophiliacs, by using multiple serological markers and the polymerase chain reaction (PCR). Twenty-nine hemophiliacs, negative for HIV antibodies, were treated for 18 mo
The influence of mental health problems on AIDS-related risk behaviors in young adults.: J Nerv Ment Dis. 1992 May;180(5):314-20. Unique Identifier : AIDSLINE MED/92260203; Stiffman AR; Dore P; Earls F; Cunningham R; George Warren Brown School of Social Work, Washington University,; St Louis, Missouri 63130.; This paper explores how symptoms of mental health problems influence acquired immune deficiency syndrome-related risk behaviors, and how changes in those symptoms relate to risk behaviors engaged in by young adults. Repeated interviews with 602 youths since 1984 provide a history of change in behaviors. Mental health
HLA profile and HTLV-I associated myelopathy (HAM/TSP) in Natal, South Africa [letter]: J Neurol Neurosurg Psychiatry. 1992 Apr;55(4):329-30. Unique Identifier : AIDSLINE MED/92260260; Bhigjee AI; Bill PL; Hammond MG; Windsor IM
Expression of major histocompatibility complex antigens in the brains of patients with progressive multifocal leukoencephalopathy.: J Neuropathol Exp Neurol. 1992 May;51(3):257-63. Unique Identifier : AIDSLINE MED/92260270; Achim CL; Wiley CA; Department of Pathology, University of California, San Diego, La; Jolla 92093-0612.; Progressive multifocal leukoencephalopathy (PML) is caused by JC virus (JCV) infection of the central nervous system (CNS) in immunosuppressed patients. The immunopathogenesis of this chronic encephalitis is unknown. Because major histocompatibility (MHC) class I and class II antigens are important in modulating the i
Periodontal health in 200 HIV-positive patients.: J Oral Pathol Med. 1992 Mar;21(3):124-7. Unique Identifier : AIDSLINE MED/92260408; Riley C; London JP; Burmeister JA; Laboratory of Microbial Ecology, NIDR, NIH, Bethesda, MD 20892.; Two hundred HIV-positive subjects were surveyed to determine their periodontal health status. Particular attention was given to the occurrence of a severe and rapidly progressing form of periodontal disease designated HIV-associated periodontitis, which has been reported as being unique to AIDS patients. Among the sub
Fluconazole: a new option in the treatment of Candida mucositis and esophageal candidiasis.: J Otolaryngol. 1992 Apr;21(2):92-4. Unique Identifier : AIDSLINE MED/92260591; Garber GE; Department of Medicine, Ottawa General Hospital, Ontario, Canada.; Fluconazole is a new triazole antifungal agent with good activity against Candida and cryptococcal meningitis. It is well-tolerated and effective in immunosuppressed patients with oral-pharyngeal candidiasis. This review outlines the characteristics of fluconazole and discusses its role among the class of antifungal a
Effects of deletions in the cytoplasmic domain on biological functions of human immunodeficiency virus type 1 envelope glycoproteins.: J Virol. 1992 Jun;66(6):3306-15. Unique Identifier : AIDSLINE MED/92260597; Gabuzda DH; Lever A; Terwilliger E; Sodroski J; Division of Human Retrovirology, Dana-Farber Cancer Institute,; Boston, Massachusetts 02115.; The role of the cytoplasmic domain of the human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins in virus replication was investigated. Deletion of residues 840 to 856 at the carboxyl terminus of gp41 reduced the efficiency of virus entry during an early step in the virus life cycle between CD4 binding and
Human immunodeficiency virus type 2 infection and fusion of CD4-negative human cell lines: induction and enhancement by soluble CD4.: J Virol. 1992 Jun;66(6):3531-7. Unique Identifier : AIDSLINE MED/92260623; Clapham PR; McKnight A; Weiss RA; Chester Beatty Laboratories, Institute of Cancer Research,; London, England.; We describe human immunodeficiency type 2 (HIV-2) strains which induce cell-to-cell fusion and infect certain CD4- human cell lines. Soluble CD4 (sCD4) induces or enhances fusion by most HIV-2 strains tested. Soluble CD4-immunoglobulin G chimeras and conjugates of sCD4 and antibody to the third domain of CD4 block HIV
Derivation of neurotropic simian immunodeficiency virus from exclusively lymphocytetropic parental virus: pathogenesis of infection in macaques.: J Virol. 1992 Jun;66(6):3550-6. Unique Identifier : AIDSLINE MED/92260625; Sharma DP; Zink MC; Anderson M; Adams R; Clements JE; Joag SV; Narayan O; Division of Comparative Medicine, Johns Hopkins University School; of Medicine, Baltimore, Maryland 21205.; Neurological disease resulting from lentivirus (including human immunodeficiency virus) infections is usually caused by a strain of virus that replicates productively in microglia in vivo and in macrophage cultures in vitro. We undertook this study using the model of simian immunodeficiency virus in macaques (SIVmac)
Mutations in the env gene of friend spleen focus-forming virus overcome Fv-2r-mediated resistance to Friend virus-induced erythroleukemia.: J Virol. 1992 Jun;66(6):3652-60. Unique Identifier : AIDSLINE GENBANK/M90673; Majumdar MK; Cho CL; Fox MT; Eckner KL; Kozak S; Kabat D; Geib RW; Department of Life Sciences, Indiana State University, Terre; Haute.; Although Fv-2r homozygous mice are resistant to leukemias induced either by an erythropoietin-encoding virus or by wild-type Friend virus (FV) (M. E. Hoatlin, S. L. Kozak, F. Lilly, A. Chakraborti, C. A. Kozak, and D. Kabat, Proc. Natl. Acad. Sci. USA 87:9985-9989, 1990), they are susceptible to some variants of FV (R
Ribosomal frameshifting efficiency and gag/gag-pol ratio are critical for yeast M1 double-stranded RNA virus propagation.: J Virol. 1992 Jun;66(6):3669-76. Unique Identifier : AIDSLINE MED/92260639; Dinman JD; Wickner RB; Section on the Genetics of Simple Eukaryotes, National Institute; of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland; 20892.; About 1.9% of ribosomes translating the gag open reading frame of the yeast L-A double-stranded RNA virus positive strand undergo a 1 frameshift and continue translating in the pol open reading frame to make a 170-kDa gag-pol fusion protein. The importance of frameshifting efficiency for viral propagation was tested i
A specific sequence with a bulged guanosine residue(s) in a stem-bulge-stem structure of Rev-responsive element RNA is required for trans activation by human immunodeficiency virus type 1 Rev.: J Virol. 1992 Jun;66(6):3699-706. Unique Identifier : AIDSLINE MED/92260643; Holland SM; Chavez M; Gerstberger S; Venkatesan S; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892.; We demonstrate that both the in vitro RNA binding and in vivo trans activation functions of human immunodeficiency virus type 1 Rev regulatory protein Rev require the presence of a 9-nucleotide 5 -CACUAUGGG-3 RNA motif on its cognate target, the Rev-responsive element RNA. For optimal Rev recognition, this sequence m
Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription.: J Virol. 1992 Jun;66(6):3883-7. Unique Identifier : AIDSLINE MED/92260664; Liu J; Perkins ND; Schmid RM; Nabel GJ; Department of Internal Medicine, Howard Hughes Medical Institute,; University of Michigan Medical Center, Ann Arbor 48109-0650.; NF-kappa B is a protein complex which functions in concert with the tat-I gene product to stimulate human immunodeficiency virus (HIV) transcription. To determine whether specific members of the NF-kappa B family contribute to this effect, we have examined the abilities of different NF-kappa B subunits to act with Tat
Synergistic activation of the human immunodeficiency virus type 1 promoter by the viral Tat protein and cellular transcription factor Sp1.: J Virol. 1992 Jun;66(6):3932-6. Unique Identifier : AIDSLINE MED/92260673; Kamine J; Chinnadurai G; Institute for Molecular Virology, St. Louis University School of; Medicine, Missouri 63110.; We have previously shown that the human immunodeficiency virus type 1 (HIV-1) Tat protein can activate a synthetic promoter containing consensus-binding sites for the cellular transcription factor Sp1. In this report, we show that a GAL-Tat fusion protein targeted via GAL4 DNA-binding sites can also trans activate an
Tumor necrosis factor alpha negatively regulates hepatitis B virus gene expression in transgenic mice.: J Virol. 1992 Jun;66(6):3955-60. Unique Identifier : AIDSLINE MED/92260678; Gilles PN; Fey G; Chisari FV; Department of Molecular and Experimental Medicine, Scripps; Research Institute, La Jolla, California 92037.; It is well known that several inflammatory cytokines can modulate hepatocellular gene expression in a complex physiological process known as the hepatic acute-phase response. Since hepatitis B virus (HBV) characteristically induces a vigorous lymphomononuclear inflammatory response in the liver during acute and chroni
Cytoplasmic domain truncation enhances fusion activity by the exterior glycoprotein complex of human immunodeficiency virus type 2 in selected cell types.: J Virol. 1992 Jun;66(6):3971-5. Unique Identifier : AIDSLINE GENBANK/M86924; Mulligan MJ; Yamshchikov GV; Ritter GD Jr; Gao F; Jin MJ; Nail CD; Spies CP; Hahn BH; Compans RW; Department of Medicine, University of Alabama, Birmingham; 35294-0006.; To investigate the glycoprotein determinants of viral cytopathology, we constructed chimeric env genes between a noncytopathic strain of human immunodeficiency virus type 2 (HIV-2), designated HIV-2/ST, and a highly fusogenic and cytopathic variant derived from this virus. Expression of the resulting chimeric glycopro
OSHA bloodborne pathogens standard aims to limit occupational transmission [news]: JAMA. 1992 Jun 3;267(21):2853-4. Unique Identifier : AIDSLINE MED/92260683; Goldsmith MF
As number of trials increases, gene therapy begins to look promising for medicine's future [news]: JAMA. 1992 Jun 3;267(21):2854-5. Unique Identifier : AIDSLINE MED/92260684; Marwick C
From the Centers for Disease Control. Investigations of patients who have been treated by HIV-infected health-care workers.: JAMA. 1992 Jun 3;267(21):2864, 2867. Unique Identifier : AIDSLINE MED/92260688
Percutaneous injuries during operation. Who is at risk for what? [editorial; comment]: JAMA. 1992 Jun 3;267(21):2938-9. Unique Identifier : AIDSLINE MED/92260710; Nichols RL
[Children of drug-dependent mothers--personal experiences and review of the literature]: Klin Padiatr. 1992 Mar-Apr;204(2):92-7. Unique Identifier : AIDSLINE MED/92260881; Bode H; Fabian T; Rudin C; Nars PW; Heinzl S; Univ. Kinderspital Basel.; The increasing incidence of drug abuse in central Europe leads to a growing number of children with intrauterine drug exposure. During pregnancy various risks affect these children. Postnatally severe symptoms of withdrawal are observed frequently. The psychosocial development is endangered. Between 1986 and 1990 30 d
[Hemolytic anemia due to cold-reacting antibodies: association with human immunodeficiency virus infection and non-Hodgkin's lymphoma]: Med Clin (Barc). 1992 Apr 4;98(13):502-4. Unique Identifier : AIDSLINE MED/92261098; Lopez Dupla JM; Rodriguez Perez A; Martinez Martinez P; de Castro Carpeno J; Lavilla Uriol P; Gil Aguado A; Servicio de Medicina Interna, Hospital La Paz, Madrid.; Hemolytic disease by cold-reacting antibodies is a rare form of hemolytic anemia. In most cases a subjacent cause is found. This disease is generally related with reactive lymphoproliferative processes (infections by the Epstein-Barr virus and cytomegalovirus ) or uncontrolled lymph
[Acute pancreatitis associated with varicella-zoster virus infection in a patient with acquired immunodeficiency syndrome]: Med Clin (Barc). 1992 Mar 7;98(9):339-41. Unique Identifier : AIDSLINE MED/92261112; Fernandez de la Puebla Gimenez RA; Lechuga Varona T; Kindelan Jaquotot JM; Jurado Jimenez R; Delgado Blanco M; de Non-Louis y Persson E; Unidad de Enfermedades Infecciosas, Hospital Regional; Universitario Reina, Sofia, Cordoba.; A patient with the acquired immunodeficiency syndrome (AIDS) who developed acute pancreatitis (AP) during the course of a disseminated herpes zoster is presented. Diagnosis was based on the simultaneity of abdominal pain with hyperamylasemia, the dissemination of the cutaneous lesions and the positive varicella-zoster
A unique monoclonal antibody that recognizes mature p17 of HIV-1 but not its precursor.: Microbiol Immunol. 1992;36(1):105-11. Unique Identifier : AIDSLINE MED/92261370; Saitoh A; Tanaka N; Nakata A; Ikuta K; Shinagawa H; Department of Experimental Chemotherapy, Osaka University, Japan.; The entire and partial gag regions of human immunodeficiency virus type 1 (HIV-1) were overproduced in Escherichia coli and used for epitope mapping of antibodies against p17. We found that a mouse monoclonal antibody to p17, V17 recognizes the mature p17 but not the unprocessed Gag proteins containing the entire p17
Potential role of the viral protease in human immunodeficiency virus type 1 associated pathogenesis.: Med Hypotheses. 1992 Mar;37(3):137-50. Unique Identifier : AIDSLINE MED/92261417; Shoeman RL; Honer B; Mothes E; Traub P; Max-Planck-Institut fur Zellbiologie, Ladenburg, Federal; Republic of Germany.; Infection with the human immunodeficiency virus type 1 (HIV-1) results in a variety of pathological changes culminating in the acquired immune deficiency syndrome (AIDS). While most of these changes can readily be accounted for either by direct effects of HIV-1 on the immune system or by indirect effects of secondary
Minnesota HIV/HBV Joint Task Force recommendations. Executive summary.: Minn Med. 1992 Apr;75(4):32-5. Unique Identifier : AIDSLINE MED/92261500
The result of an educational intervention for physicians providing HIV-antibody testing and counseling.: Minn Med. 1992 Apr;75(4):37-9. Unique Identifier : AIDSLINE MED/92261501; Terry P; Pheley A; Williams D; Strickland S; Based upon our findings related to physicians human immunodeficiency virus (HIV) antibody-testing practices in a multispecialty group practice, we randomly selected a group of family practice physicians and over six months provided them with patient education resources and information about HIV-antibody-testing guide
New OSHA rule governs employees' exposure to bloodborne pathogens.: Minn Med. 1992 Apr;75(4):40-2. Unique Identifier : AIDSLINE MED/92261502; Colovic MA
AZT research [news]: Minn Med. 1992 Apr;75(4):53. Unique Identifier : AIDSLINE MED/92261506
HIV seroprevalence among adults treated for cardiac arrest before reaching a medical facility--Seattle, Washington, 1989-1990.: MMWR Morb Mortal Wkly Rep. 1992 May 29;41(21):381-3. Unique Identifier : AIDSLINE MED/92261547; As part of an ongoing study of determinants of out-of-hospital cardiac arrest, the Seattle-King County Department of Health conducted an anonymous human immunodeficiency virus (HIV) serosurvey of these patients in Seattle from January 1989 through December 1990. The serum specimens were obtained from patients for whom
Manipulating the immune system with immune globulin. The National Institute of Child Health and Human Development. Intravenous Immunoglobulin Study Group [letter]: N Engl J Med. 1992 Jun 11;326(24):1636-7; discussion 1637-8. Unique Identifier : AIDSLINE MED/92261695; Mofenson LM; Shearer WT; Moye J; Nugent R; Willoughby A
AIDS vaccine 'may not work' in Africa.: Nurs RSA. 1992 Feb;7(2):14. Unique Identifier : AIDSLINE MED/92261700
AIDS helpline. Preventing exposure to disease.: Nurs RSA. 1992 Feb;7(2):15. Unique Identifier : AIDSLINE MED/92261701; Allan B
The AIDS epidemic--beyond the myths.: Nurs RSA. 1992 Mar;7(3):21-3. Unique Identifier : AIDSLINE MED/92261710
Predicting AIDS patient care intentions among nursing students [see comments]: Nurs Res. 1992 May-Jun;41(3):172-7. Unique Identifier : AIDSLINE MED/92262243; Jemmott LS; Jemmott JB 3d; Cruz-Collins M; Rutgers University, College of Nursing, Newark, NJ.; Predictors of intentions to care for AIDS patients were examined among 153 sophomore and senior nursing students. Multiple regression analysis revealed that students who had relatively less AIDS knowledge and who perceived greater occupational risk of HIV infection expressed stronger intentions to avoid caring for AID
Worrying policy [news]: Nurs Times. 1992 May 6-12;88(19):20. Unique Identifier : AIDSLINE MED/92262253; Schroeder I
More than a letter needed on HIV risks [news]: Nurs Times. 1992 May 6-12;88(19):5. Unique Identifier : AIDSLINE MED/92262267
Genetic risk factors for perinatally acquired HIV-1 infection.: Paediatr Perinat Epidemiol. 1992 Apr;6(2):215-24. Unique Identifier : AIDSLINE MED/92262338; Just J; Louie L; Abrams E; Nicholas SW; Wara D; Stein Z; King MC; School of Public Health, University of California, Berkeley; 94720.; This study evaluates genetic influence on susceptibility to perinatal HIV-1 infection among 106 Black infants from New York and San Francisco born to mothers infected with HIV-1. Genes tested by molecular techniques are HLA class II loci DRB1, DPB1 and DQA1; HLA class III loci complement C4A and C4B; alpha and beta in
Identification of highest-affinity ligands by affinity selection from equimolar peptide mixtures generated by robotic synthesis.: Proc Natl Acad Sci U S A. 1992 May 15;89(10):4505-9. Unique Identifier : AIDSLINE MED/92262468; Zuckermann RN; Kerr JM; Siani MA; Banville SC; Santi DV
Neuropathology and pathogenesis of HIV encephalopathies.: Acta Histochem Suppl. 1992;42:107-14. Unique Identifier : AIDSLINE MED/92262724; Wiestler OD; Leib SL; Brustle O; Spiegel H; Kleihues P; Laboratory of Neuropathology, University of Zurich, Switzerland.; The nervous system is frequently affected in patients with the acquired immune deficiency syndrome (AIDS). In addition to opportunistic CNS infections and cerebral lymphomas, approx. 20% of the patients develop HIV-associated encephalopathies. Two major histopathological manifestations are observed. HIV leukoencephalo
[When love is a game of improvisation ... (news)]: Rev Infirm. 1992 Feb;42(4):7. Unique Identifier : AIDSLINE MED/92262996
The HIV pandemic in Sweden: what do people really think about mandatory HIV testing?: Scand J Soc Med. 1992 Mar;20(1):19-24. Unique Identifier : AIDSLINE MED/92263051; Herlitz C; Department of Social Medicine, University of Uppsala, Sweden.; This study examines (1) how the general population of Sweden defines the concept of mandatory HIV testing; (2) what measures people consider should be taken against HIV infected individuals if mandatory testing is introduced; and (3) how the opinion of mandatory testing is affected
Women and AIDS.: Sci Am. 1992 Mar;266(3):96. Unique Identifier : AIDSLINE MED/92263063; Mayer KH; Carpenter CC; Brown University AIDS program.
NIH leak policy honored in the breach [news]: Science. 1992 May 1;256(5057):603. Unique Identifier : AIDSLINE MED/92263087
Magic lessons: rated R [editorial] [see comments]: South Med J. 1992 May;85(5):455-6. Unique Identifier : AIDSLINE MED/92263117; Thomison JB
Seroprevalence of human immunodeficiency virus among adolescent attendees of Mississippi sexually transmitted disease clinics: a rural epidemic.: South Med J. 1992 May;85(5):460-3. Unique Identifier : AIDSLINE MED/92263119; Young RA; Feldman S; Brackin BT; Thompson E; Department of Pediatrics, Children's Hospital, University of; Mississippi Medical Center, Jackson 39216.; Human immunodeficiency virus (HIV) infection among adolescents is causing increasing concern, and teenagers attending sexually transmitted disease (STD) clinics run a high risk of contracting it. To determine the status of HIV infection in a Mississippi adolescent population, we evaluated seroprevalence rates for adol
Perioperative complications of long-term central venous catheters in high-risk patients: predictors versus myths.: South Med J. 1992 May;85(5):498-501. Unique Identifier : AIDSLINE MED/92263125; Azarow KS; Molloy M; Kavolius J; Sayles J; Cabellon S Jr; Pearl RH; Department of General Surgery, Walter Reed Army Medical Center,; Washington, DC 20307-5001.; A prospective cohort of 126 patients having long-term central venous catheterization was collected over a 10-month period. The patients were preoperatively assessed for the following risk factors: previous catheter placement, an absolute neutrophil count less than 500/mm3, a platelet count less than 50,000/mm3, a BUN
Courvoisier's sign revisited: two patients with palpable gallbladder.: South Med J. 1992 May;85(5):548-50. Unique Identifier : AIDSLINE MED/92263134; Fournier AM; Michel J; Department of Medicine, University of Miami School of Medicine,; Fla. 33101.; More than a century ago, Courvoisier published his observation on the significance of a palpable gallbladder in the differential diagnosis of obstructive jaundice. We have described two patients with newly described conditions--AIDS-associated cholangiopathy and diet-induced cholecystitis--who had a palpable gallbladd
Correction of HIV-associated thrombocytopenia with low doses of interferon alfa.: South Med J. 1992 May;85(5):557-9. Unique Identifier : AIDSLINE MED/92263137; Murphy KP; Stein MD; D'Amico RP; Brown University Program in Medicine, Rhode Island Hospital,; Providence 02903.; We have presented a case of HIV-associated thrombocytopenia successfully treated with low dose interferon alfa-2a. Increases in platelet levels were achieved within 1 week without hospitalization or surgery. Further, the patient had no systemic side effects from therapy. Zidovudine alone was ineffective in maintaining
Adult T-cell leukaemia/lymphoma associated with HTLV-I in Natal [letter]: S Afr Med J. 1992 May 16;81(10):528-9. Unique Identifier : AIDSLINE MED/92263153; Jogessar VB; de Bruyn CC; Bhigjee AI; Naicker VL; Bill PL; Tait D
AIDS and the lung: update 1992. 1. Pneumocystis carinii pneumonia.: Thorax. 1992 Apr;47(4):305-14. Unique Identifier : AIDSLINE MED/92263260; Miller RF; Mitchell DM; Department of Medicine, University College and Middlesex School; of Medicine, Middlesex Hospital, London.
Feline AIDS: symptoms and treatment.: Tijdschr Diergeneeskd. 1992 Apr;117 Suppl 1:26S. Unique Identifier : AIDSLINE MED/92263281; Egberink HF; Horzinek MC; Department of Virology, Faculty of Veterinary Medicine,; University of Utrecht, The Netherlands.
A survey of allied health students' knowledge of HIV and AIDS.: Todays OR Nurse. 1992 May;14(5):16-23. Unique Identifier : AIDSLINE MED/92263432; Beitz JM; 1. The best and only preventative treatment for AIDS is quality, in-depth education. 2. Increasing the knowledge of adolescents and young adults is not easy despite enormous media exposure; many engage in high-risk behaviors, believing themselves to be invulnerable to infection. 3. Although respondents reported that t
Extrachromosomal human immunodeficiency virus type 1 sequences are methylated in latently infected U937 cells.: Virology. 1992 Jun;188(2):451-8. Unique Identifier : AIDSLINE MED/92263747; Singh MK; Pauza CD; Aaron Diamond AIDS Research Center, New York, New York 10016.; Long-term human immunodeficiency virus type 1 (HIV-1) infection of the human monocytic cell line U937 resulted in a progressive loss of infectivity that was correlated with the accumulation of stable, extrachromosomal forms of viral DNA. Viral latency was also characterized by reduced levels of HIV-1 transcription. Th
Identification of amino acid residues critical for endonuclease and integration activities of HIV-1 IN protein in vitro.: Virology. 1992 Jun;188(2):459-68. Unique Identifier : AIDSLINE MED/92263748; Drelich M; Wilhelm R; Mous J; Department of Biology, F. Hoffmann-LaRoche, Ltd., Basel,; Switzerland.; HIV-IN protein, tagged with a hexahistidine tail was expressed in Escherichia coli and purified by a one-step nickel chelate affinity chromatography procedure. The purified IN protein was characterized in terms of its endonuclease and integrase properties in vitro. Specific cleavage and integration of HIV U5 LTR ends
Studies on compartmentation and turnover of murine retrovirus envelope proteins.: Virology. 1992 Jun;188(2):477-85. Unique Identifier : AIDSLINE MED/92263750; Yu Y; Wong PK; University of Texas M. D. Anderson Cancer Center, Science; Park-Research Division, Smithville 78957.; Several aspects of turnover and degradation of cell membrane proteins were studied in an NIH 3T3 cell clone expressing the env gene of Moloney murine leukemia virus ts1. Both internalization and shedding of the extracellular domain of the envelope protein gp70 occurred at the cell surface, albeit, in the case of shedd
RNA packaging signal of human immunodeficiency virus type 1.: Virology. 1992 Jun;188(2):590-9. Unique Identifier : AIDSLINE MED/92263762; Hayashi T; Shioda T; Iwakura Y; Shibuta H; Department of Viral Infection, University of Tokyo, Japan.; Cells infected with a recombinant vaccinia virus carrying the gag and pol regions of the human immunodeficiency virus type 1 genome (Vac-gag/pol) released human immunodeficiency virus (HIV)-like particles containing HIV-specific RNA. However, cells infected with another recombinant vaccinia, Vac-gag/pol-dP, derived th
Reexamination of the coding potential of the HTLV-1 pX region.: Virology. 1992 Jun;188(2):618-27. Unique Identifier : AIDSLINE MED/92263765; Caputo A; Haseltine WA; Dana Farber Cancer Institute, Department of Human Retrovirology,; Boston, Massachusetts 02115.; The human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T cell leukemia (ATL) and tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM). In addition to tax and rex genes eight additional open reading frames are present in the pX region of HTLV-1. The possibility that these open re
HTLV-I Tax is a zinc-binding protein: role of zinc in Tax structure and function.: Virology. 1992 Jun;188(2):754-64. Unique Identifier : AIDSLINE MED/92263779; Semmes OJ; Jeang KT; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, Maryland 20892.; We have examined the functional significance of the cysteine- and histidine-rich region (amino acids 22-53) of HTLV-I Tax. A modeling of this region suggests two possible overlapping zinc-finger-like motifs. Using a zinc blotting technique, we show that Tax binds zinc. An N-terminal deletion in Tax that removed this z
Replication of HIV-1 and HIV-2 in human bone marrow cultures.: Virology. 1992 Jun;188(2):840-9. Unique Identifier : AIDSLINE MED/92263788; Potts BJ; Hoggan MD; Lamperth L; Spivak J; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, Maryland 20892.; The bone marrow is a target organ for the human immunodeficiency virus (HIV), but the mechanisms by which suppression of hematopoiesis occurs during the course of HIV infection are not well understood. To study this issue, the effect of several different HIV-1 isolates (monotrophic and lymphotrophic) and one HIV-2 iso
Isolation and characterization of a highly divergent HIV-2[GH-2]: generation of an infectious molecular clone and functional analysis of its rev-responsive element in response to primate retrovirus transactivators (Rev and Rex).: Virology. 1992 Jun;188(2):850-3. Unique Identifier : AIDSLINE MED/92263789; Kawamura M; Katahira J; Fukasawa M; Sakuragi J; Ishikawa K; Nakai M; Mingle JA; Osei-Kwasi M; Netty VB; Akari H; et al; Institute for Virus Research, Kyoto University, Japan.; A highly divergent HIV-2 designated as HIV-2[GH-2] was obtained from an AIDS-related complex (ARC) patient in Ghana . A full-length molecular clone of this isolate was obtained and a biologically active clone was constructed. Its restriction pattern differed from that of prototype HI
Virus-cell membrane fusion does not predict efficient infection of alveolar macrophages by human immunodeficiency virus type 1 (HIV-1).: Virology. 1992 Jun;188(2):864-8. Unique Identifier : AIDSLINE MED/92263792; Potash MJ; Zeira M; Huang ZB; Pearce TE; Eden E; Gendelman HE; Volsky DJ; Molecular Virology Laboratory, St. Luke's/Roosevelt Hospital; Center, New York, New York.; Alveolar macrophages (AM) are the principal target cells for HIV-1 in lung tissue. To investigate the mechanisms of HIV-1 infection and efficient replication in these cells we isolated AM from 14 HIV-1 negative donors and exposed them to two virus isolates, either N1T, which replicates well in T lymphocytic and monocy
Retroviral envelope protein fusions to secreted and membrane markers.: Virology. 1992 Jun;188(2):869-74. Unique Identifier : AIDSLINE MED/92263793; Mace MC; Hansen M; Whiting S; Wang CT; Barklis E; Vollum Institute, Portland, Oregon.; We have analyzed a series of Moloney murine leukemia (M-MuLV) envelope (env) protein fusions to the marker proteins invertase and placental alkaline phosphatase (PLAP), expressed in Psi2 retrovirus packaging cells. The yeast invertase protein, fused at its third amino acid residue to the amino-terminal signal sequence
Sexual behavior and status for human immunodeficiency virus type 1 among homosexual and bisexual males in Mexico City.: Am J Epidemiol. 1992 Apr 15;135(8):883-94. Unique Identifier : AIDSLINE MED/92264328; Hernandez M; Uribe P; Gortmaker S; Avila C; De Caso LE; Mueller N; Sepulveda J; Ministry of Health, Mexico City, Mexico.; The authors examined sexual behaviors, the seroprevalence of human immunodeficiency virus type 1 (HIV-1), and condom use among 2,314 homosexual and bisexual men tested during 1988-1989 at the AIDS (acquired immunodeficiency syndrome) National Center in Mexico City. Bisexuals constituted 24% of the sample; the seroprev
Thrombotic thrombocytopenic purpura in patients with human immunodeficiency virus infection: a report of three cases and review of the literature.: Am J Hematol. 1992 Jun;40(2):103-9. Unique Identifier : AIDSLINE MED/92264334; Rarick MU; Espina B; Mocharnuk R; Trilling Y; Levine AM; Department of Internal Medicine, USC School of Medicine, Los; Angeles 90033.; Three cases of thrombotic thrombocytopenic purpura (TTP) and coexistent human immunodeficiency virus (HIV) infection are presented with a review of 15 cases reported in the literature. Of the 18 total patients, one-half presented with no symptoms of HIV infection while nine patients presented with symptomatic HIV dise
Physician and infection control practitioner HIV/AIDS reporting characteristics.: Am J Public Health. 1992 Jun;82(6):889-91. Unique Identifier : AIDSLINE MED/92264442; Jones JL; Meyer P; Garrison C; Kettinger L; Hermann P; South Carolina Department of Health and Environmental Control,; Columbia 29201.; We surveyed a random sample of South Carolina physicians and infection control practitioners about the reporting of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) cases. Of physicians surveyed, 79% indicated that HIV infection as well as AIDS should be reported by name. The following
Community-based case management of HIV disease [news]: Am J Public Health. 1992 Jun;82(6):893-4. Unique Identifier : AIDSLINE MED/92264444; Payne FJ; Sharrett CS; Poretz DN; Eron LJ; Stage T; Foroobar R; Bowman C; Miller RK
Evolving epidemiology of HIV infection among adults.: Ann Allergy. 1992 May;68(5):375-85. Unique Identifier : AIDSLINE MED/92264512; Koziol DE; Henderson DK; Hospital Epidemiology Service, Warren G. Magnuson Clinical; Center, National Institutes of Health, Bethesda, Maryland.; Whereas new, or changes in existing, routes of transmission of HIV have not been identified in the 11 years since AIDS was identified as a clinical syndrome, changes in the epidemiology of HIV infection in the US have been identified during that period. The role of injection drug use as a risk for both parenteral and
Primary pulmonary hypertension in association with human immunodeficiency virus infection. A possible viral etiology for some forms of hypertensive pulmonary arteriopathy.: Am Rev Respir Dis. 1992 May;145(5):1196-200. Unique Identifier : AIDSLINE MED/92264595; Mette SA; Palevsky HI; Pietra GG; Williams TM; Bruder E; Prestipino AJ; Patrick AM; Wirth JA; Pulmonary Division, University of Pennsylvania School of; Medicine, Philadelphia.; Recent reports have suggested a possible association between HIV-1 infection and primary pulmonary hypertension (PPH), but most of the patients described to date have either had acquired immunodeficiency syndrome (AIDS) with concurrent lung infections or have administered Factor VIII intravenously for hemophilia. We r
Detection of cryptococcal antigen in bronchoalveolar lavage fluid: a prospective study of diagnostic utility.: Am Rev Respir Dis. 1992 May;145(5):1226-9. Unique Identifier : AIDSLINE MED/92264603; Baughman RP; Rhodes JC; Dohn MN; Henderson H; Frame PT; Department of Internal Medicine, University of Cincinnati Medical; Center, Ohio.; Cryptococcal pneumonia is associated with significant morbidity and mortality in immunocompromised patients. We examined the utility of screening bronchoalveolar lavage (BAL) fluid for cryptococcal antigen. In a pilot study, we found that cryptococcal antigen was always positive in unprocessed BAL specimens of seven p
Quality-of-life evaluation in a clinical trial of zidovudine therapy in patients with mildly symptomatic HIV infection. The AIDS Clinical Trials Group.: Ann Intern Med. 1992 Jun 15;116(12 Pt 1):961-6. Unique Identifier : AIDSLINE MED/92264642; Gelber RD; Lenderking WR; Cotton DJ; Cole BF; Fischl MA; Goldhirsch A; Testa MA; Division of Biostatistics and Epidemiology, Dana-Farber Cancer; Institute, Boston, MA 02115.; OBJECTIVE: To evaluate the effects of zidovudine therapy in patients with mildly symptomatic HIV infection using Q-TWiST (quality-adjusted: Time Without Symptoms and Toxicity). DESIGN: Analysis of a previously reported multicenter, randomized, placebo-controlled clinical trial. SETTING: Thirty-two AIDS Clinical Trial
Typhlitis in patients with HIV-1 infection [see comments]: Ann Intern Med. 1992 Jun 15;116(12 Pt 1):998-1000. Unique Identifier : AIDSLINE MED/92264650; Till M; Lee N; Soper WD; Murphy RL; Northwestern University Medical School, Department of Medicine,; Chicago, IL 60611.
Cytokine expression in the brain during the acquired immunodeficiency syndrome.: Ann Neurol. 1992 Apr;31(4):349-60. Unique Identifier : AIDSLINE MED/92264695; Tyor WR; Glass JD; Griffin JW; Becker PS; McArthur JC; Bezman L; Griffin DE; Department of Neurology, Johns Hopkins University School of; Medicine, Baltimore, MD.; The pathogenesis of central nervous system (CNS) disease in acquired immunodeficiency syndrome (AIDS) is poorly understood but may be related to specific effects of the immune system. Cytokines such as tumor necrosis factor and interleukin-1 may have toxic effects on CNS cells and have been postulated to contribute to
Human immunodeficiency virus infection in microglia: correlation between cells infected in the brain and cells cultured from infectious brain tissue.: Ann Neurol. 1992 Apr;31(4):361-5. Unique Identifier : AIDSLINE MED/92264696; Brinkmann R; Schwinn A; Narayan O; Zink C; Kreth HW; Roggendorf W; Dorries R; Schwender S; Imrich H; ter Meulen V; Institut fur Virologie und Immunobiologie, Johns Hopkins; University School of Medicine, Baltimore, MD.; In acquired immunodeficiency syndrome, the lesions of the central nervous system in association with the human immunodeficiency virus are thought to be related to an infection of microglia, although no studies are available in which cultured and physiological characteristics of microglia cells infected in vivo have be
Relationships over 1 year between lymphocyte subsets and psychosocial variables among adults with infection by human immunodeficiency virus [see comments]: Arch Gen Psychiatry. 1992 May;49(5):396-401. Unique Identifier : AIDSLINE MED/92264879; Perry S; Fishman B; Jacobsberg L; Frances A; Department of Psychiatry, Cornell University Medical College, New; York, NY.; To examine relationships between immune and psychosocial variables among adults infected with human immunodeficiency virus type 1, 221 subjects without acquired immunodeficiency syndrome were assessed for degree of depression, anxiety, psychiatric symptoms, social support, stressful life events, hardiness, hopelessnes
Synthesis and anti-HIV-1 activity of N-hydroxy-N1-aminoguanidines.: Arzneimittelforschung. 1992 Jan;42(1):65-9. Unique Identifier : AIDSLINE MED/92265046; Doubell PC; Oliver DW; Department of Pharmaceutical Chemistry, Pretoria College of; Pharmacy, University of Pretoria, Republic of South Africa.; The synthesis of 13 new Schiff bases of N-hydroxy-N1-aminoguanidines starting from thiosemicarbazide are reported. These new derivatives were for the first time tested against infection by the Human Immunodeficiency Virus Type 1 (HIV-1) using the human T-lymphocyte cell line. Four N-hydroxy-N1-aminoguanidines exhibite
Mouth-to-mouth ventilation: the dying art.: Am J Emerg Med. 1992 Mar;10(2):156-61. Unique Identifier : AIDSLINE MED/92265082; Michael AD; Forrester JS; Central Cardiology, Bakersfield, CA 93301.
Interferon-gamma may enhance infection of blood-derived macrophages with HIV-1 in the presence of HIV-positive serum.: APMIS. 1992 May;100(5):465-9. Unique Identifier : AIDSLINE MED/92265293; Degre M; Beck S; Rollag H; Virology section, Wilhelmsens Institute of Bacteriology,; University of Oslo, Rikshospitalet, Norway.; HIV multiplication in blood-derived macrophages was slightly inhibited by pretreatment of cells with interferon-gamma or by preincubation of virus with serum containing antibodies against HIV. When these pretreatments were combined, the HIV titres observed a short time after infection were enhanced. This effect was bl
Trainees' knowledge of AIDS and HIV [letter; comment]: Br J Gen Pract. 1992 Apr;42(357):171. Unique Identifier : AIDSLINE MED/92265452; Tamin J
The spontaneous regression of lymphoma in AIDS.: Clin Oncol (R Coll Radiol). 1992 May;4(3):196-7. Unique Identifier : AIDSLINE MED/92265682; Daniels D; Lowdell CP; Glaser MG; Department of Genito-urinary Medicine, Charing Cross Hospital,; London, UK.; Non-Hodgkin s lymphomas are an increasing problem in the AIDS population. They are generally aggressive, high-grade lymphomas and more commonly present at extranodal sites, particularly the central nervous system. Although chemo- and radiosensitive, the duration of response is generally short lived. Spontaneous remiss
Initial experience with CAPD in patients with HIV infection in a developing country [letter]: Perit Dial Int. 1992;12(2):267-8. Unique Identifier : AIDSLINE MED/92265800; Mcligeyo SO
Productive human immunodeficiency virus-1 infection of megakaryocytic cells is enhanced by tumor necrosis factor-alpha.: Blood. 1992 May 15;79(10):2670-9. Unique Identifier : AIDSLINE MED/92265921; Monte D; Groux H; Raharinivo B; Plouvier B; Dewulf J; Clavel T; Grangette C; Torpier G; Auriault C; Capron A; et al; Centre d'Immunologie et de Biologie Parasitaire, Unite Mixte; INSERM 167-CNRS 624, Institut Pasteur de Lille, France.; Recent findings have indicated that megakaryocytes may be susceptible to human immunodeficiency virus (HIV) infection, suggesting a potential role for megakaryocytes as viral reservoirs in HIV-infected patients. We report that the megakaryocytic cell line Dami could be productively infected with the HTLV III-B strain
Purity of factor VIII concentrates and immune function in hemophiliacs [letter; comment]: Blood. 1992 May 15;79(10):2800-1. Unique Identifier : AIDSLINE MED/92265942; Farrugia A
Anorectal HIV infection and AIDS: diagnosis and management.: Baillieres Clin Gastroenterol. 1992 Mar;6(1):95-103. Unique Identifier : AIDSLINE MED/92266021; Sim A
Immunological abnormalities in haemophiliacs.: Blood Rev. 1992 Mar;6(1):26-33. Unique Identifier : AIDSLINE MED/92266028; Watson HG; Ludlam CA; Department of Haematology, Royal Infirmary of Edinburgh, UK.; 10 years ago, it became apparent that haemophiliacs were developing diseases which were indicative of underlying immunodeficiency. The results of investigation confirmed that many had abnormal immune systems, particularly with regard to cell-mediated immunity. These abnormalities were thought to be a consequence of th
Platelet antibodies in immune thrombocytopenia.: Blood Rev. 1992 Mar;6(1):34-42. Unique Identifier : AIDSLINE MED/92266029; Hegde UM; Department of Haematology, Ealing Hospital, Southall, Middx, UK.; Several tests to detect antibodies to platelets in patients with immune thrombocytopenia have been developed over the 40 years since it was first noted that this disorder was mediated by antiplatelet factors. Early tests were crude and not reproducible. A major landmark was the quantitation of IgG immunoglobulin on pl
Prevalence of HIV antibody in forensic cases.: BMJ. 1992 Apr 18;304(6833):1027-8. Unique Identifier : AIDSLINE MED/92266038; Sadler DW; Pounder DJ; Urquhart GE; Porter-Boveri M; Department of Forensic Medicine, Royal Infirmary, University of; Dundee.
Recording HIV status on police computers [editorial] [see comments]: BMJ. 1992 Apr 18;304(6833):995-6. Unique Identifier : AIDSLINE MED/92266067; Mason JK
Prevalence of HIV among childbearing women and women having termination of pregnancy: multidisciplinary steering group study.: BMJ. 1992 Apr 25;304(6834):1082-5. Unique Identifier : AIDSLINE MED/92266079; Goldberg DJ; MacKinnon H; Smith R; Patel NB; Scrimgeour JB; Inglis JM; Peutherer JF; Urquhart GE; Emslie JA; Covell RG; et al; Communicable Diseases (Scotland) Unit, Ruchill Hospital, Glasgow.; OBJECTIVE--To determine the prevalence of HIV among pregnant women, in particular those whose behaviour or that of their partners put them at low risk of infection. DESIGN--Voluntary named or anonymous HIV testing of pregnant women during 21 months (November 1988 to July 1990). SUBJECTS AND SETTING--All women who plan
Ban on home HIV tests is unjustified [letter]: BMJ. 1992 Apr 25;304(6834):1118. Unique Identifier : AIDSLINE MED/92266106; Gore SM
The challenges of HIV nephropathy.: Cleve Clin J Med. 1992 Mar-Apr;59(2):142. Unique Identifier : AIDSLINE MED/92266557; Appel GB; Columbia-Presbyterian Medical Center, New York.
Auditory function in patients infected with the human immunodeficiency virus.: Clin Otolaryngol. 1992 Apr;17(2):117-21. Unique Identifier : AIDSLINE MED/92266594; Birchall MA; Wight RG; French PD; Cockbain Z; Smith SJ; Department of ENT Surgery, St Mary's Hospital, London, UK.; A prospective study of auditory function in 18 HIV positive male patients at different CDC (Centres for Disease Control) stages was undertaken. One-third had abnormalities on either auditory evoked response testing or pure tone audiometry. No correlation was found between interwave latencies I-V, I-III, III-V and stag
Ga-67 scintigraphy and computed tomography in the diagnosis of pneumocystis carinii pneumonia in patients with AIDS. A prospective comparison.: Clin Nucl Med. 1992 May;17(5):387-94. Unique Identifier : AIDSLINE MED/92266631; Tumeh SS; Belville JS; Pugatch R; McNeil BJ; Department of Radiology, Brigham & Women's Hospital, Harvard; Medical School, Boston, Massachusetts.; A prospective evaluation of Ga-67 scintigraphy and transmission computed tomography was performed in 70 consecutive patients with AIDS who were suspected of having Pneumocystis carinii pneumonia. Studies were evaluated independently by two observers. Receiver operating characteristic curves were plotted. Although scin
In-111 leukocyte imaging in disseminated mycobacterium avium-intracellulare infection.: Clin Nucl Med. 1992 May;17(5):409-10. Unique Identifier : AIDSLINE MED/92266639; Palestro CJ; Roumanas P; Swyer AJ; Kim CK; Goldsmith SJ; Department of Physics-Nuclear Medicine, Mt. Sinai School of; Medicine, Mt. Sinai Medical Center, New York, New York.
[Primary pulmonary hypertension and mesangioproliferative glomerulonephritis in HIV infection]: Dtsch Med Wochenschr. 1992 May 22;117(21):815-8. Unique Identifier : AIDSLINE MED/92266883; Reiser P; Opravil M; Pfaltz M; Speich R; Schneider J; Departement fur Pathologie, Universitatsspital, Zurich.; Four years after an HIV infection and without any preceding illness characteristic of AIDS, a 24-year-old woman developed dyspnoea on exertion and peripheral oedema. She had for several years been an intravenous drug addict and contracted hepatitis A and B. There were no symptoms of the HIV infection. Clinical, radiol
AIDS in women.: Eur J Obstet Gynecol Reprod Biol. 1992 Mar 23;44(1):31-2. Unique Identifier : AIDSLINE MED/92267213
AIDS and victims of sexual assault [see comments]: Hosp Community Psychiatry. 1992 May;43(5):447-8. Unique Identifier : AIDSLINE MED/92267472; Burgess AW; Baker T; University of Pennsylvania School of Nursing, Philadelphia 19104.
Developing family planning services for female chronic mentally ill outpatients.: Hosp Community Psychiatry. 1992 May;43(5):475-8. Unique Identifier : AIDSLINE MED/92267476; Coverdale J; Aruffo J; Grunebaum H; Baylor College of Medicine, Houston.; The family planning needs of chronic mentally ill women outpatients, many of whom do not use contraceptives and are at high risk for unwanted pregnancies, have been rarely addressed. Taking a thorough sexual history is the first step in assessing patients need for family planning services. Patient education, includin
Assessment of risk behaviors for HIV infection among psychiatric inpatients.: Hosp Community Psychiatry. 1992 May;43(5):482-5. Unique Identifier : AIDSLINE MED/92267478; Volavka J; Convit A; O'Donnell J; Douyon R; Evangelista C; Czobor P; Nathan S. Kline Institute for Psychiatric Research, Orangeburg,; NY 10962.; A 13-item questionnaire was constructed to assess risk factors for HIV infection among 476 patients newly admitted over a one-year period to a state psychiatric hospital in New York City. Because psychopathology can affect patients self-reports, the validity of the instrument was established by HIV antibody tests in
Vaccinia recombinants as vaccine vectors.: Immunobiology. 1992 Feb;184(2-3):126-46. Unique Identifier : AIDSLINE MED/92267541; Mahr A; Payne LG; Applied bioTechnology, Cambridge, Massachusetts.
Vaccination against HIV.: Immunobiology. 1992 Feb;184(2-3):193-207. Unique Identifier : AIDSLINE MED/92267545; Norley S; Kurth R; Paul Ehrlich Institute, Langen, Germany.; The spread of AIDS progresses unrelentingly despite all efforts of public education and the only real hope of epidemiological control lies in the development of an effective vaccine. The very nature of the AIDS virus (HIV) and the manner with which it interacts with the host makes development of a practical vaccine ve
Identification and initial characterization of five Cryptosporidium parvum sporozoite antigen genes.: Infect Immun. 1992 Jun;60(6):2343-8. Unique Identifier : AIDSLINE MED/92267648; Petersen C; Gut J; Leech JH; Nelson RG; Parasitology Laboratory, San Francisco General Hospital,; California.; Cryptosporidium parvum, an Apicomplexan parasite of gastrointestinal epithelial cells, causes severe disease in persons with AIDS and is a common cause of self-limited diarrhea in children, animal handlers, and residents of developing countries. No approved therapy exists; in research studies, however, hyperimmune bov
Human immunodeficiency virus type 1 enhances intracellular growth of Mycobacterium avium in human macrophages.: Infect Immun. 1992 Jun;60(6):2453-8. Unique Identifier : AIDSLINE MED/92267664; Kallenius G; Koivula T; Rydgard KJ; Hoffner SE; Valentin A; Asjo B; Ljungh C; Sharma U; Svenson SB; National Bacteriological Laboratory, Karolinska Institute,; Stockholm, Sweden.; Disseminated Mycobacterium avium infections are common in patients with AIDS and result in a reduced life expectancy. Human monocytes/macrophages are important target cells for both human immunodeficiency virus (HIV) and M. avium. We have studied the interaction in vitro of M. avium and HIV type 1 (HIV-1) in human mac
Chemical synthesis of a biotinylated derivative of the simian immunodeficiency virus protease. Purification by avidin affinity chromatography and autocatalytic activation.: J Biol Chem. 1992 May 25;267(15):10232-7. Unique Identifier : AIDSLINE MED/92268054; Tomasselli AG; Bannow CA; Deibel MR Jr; Hui JO; Zurcher-Neely HA; Reardon IM; Smith CW; Heinrikson RL; Biochemistry Unit, Upjohn Laboratories, Kalamazoo, Michigan; 49001.; The protease from simian immunodeficiency virus (SIV) was chemically synthesized by automated solid-phase technology as an NH2-terminally extended derivative, capped with biotin. Biotin-linker-(SIV protease (1-99)): the linker segment, Gly-Gly-Asp-Arg-Gly-Phe-Ala-Ala, corresponds to the amino acid sequence preceding t
Anorectal lesions in human immunodeficiency virus-infected patients.: Int J Colorectal Dis. 1992 Feb;7(1):26-30. Unique Identifier : AIDSLINE MED/92268733; Puy-Montbrun T; Denis J; Ganansia R; Mathoniere F; Lemarchand N; Arnous-Dubois N; Department of Coloproctology, Leopold Bellan Hospital, Paris,; France.; In a prospective study, we analysed the anorectal lesions observed in 148 human immunodeficiency virus-infected patients and compared the data with those reported in the literature. The majority of the patients (97.3%) were homosexual or bisexual men. The mean age of the population was 34.2 years. A history of previou
AIDS-associated Kaposi's sarcoma and the mechanisms of interferon alpha's activity; a riddle within a puzzle.: J Intern Med. 1992 Apr;231(4):321-5. Unique Identifier : AIDSLINE MED/92268768; de Wit R; Department of Medical Oncology, Rotterdam Cancer Institute, The; Netherlands.; As yet, the pathogenesis of Kaposi s sarcoma in the context of the acquired immunodeficiency syndrome (AIDS) is not completely understood; this is also true for the mechanisms of action of interferon-alpha against this tumour. The present review focuses on recent developments that may provide some further insight into
Pseudomonas infections in patients with AIDS and AIDS-related complex.: J Intern Med. 1992 Apr;231(4):437-43. Unique Identifier : AIDSLINE MED/92268786; Franzetti F; Cernuschi M; Esposito R; Moroni M; Clinic of Infectious Diseases, University of Milan, Italy.; We identified and reviewed retrospectively all the cases of infection by Pseudomonas and related genera in patients with AIDS and AIDS-related complex (ARC) who were hospitalized at our Institution over a 36-month period. We recorded 48 episodes of infection in 34 of 355 patients with AIDS, and in two of 73 patients w
CD4 T cells in murine acquired immunodeficiency syndrome: polyclonal progression to anergy.: J Exp Med. 1992 Jun 1;175(6):1589-99. Unique Identifier : AIDSLINE MED/92268807; Muralidhar G; Koch S; Haas M; Swain SL; Department of Biology, University of California, San Diego, La; Jolla 92093.; We have examined the kinetics of changes that occur in the helper T cell subset during murine acquired immunodeficiency syndrome, which occurs after infection with the mix of viruses known as BM5. We find that there is expansion of the CD4 T cells by 2 wk, 50% of the CD4 T cells become large as the disease progresses,
Cryptococcosis in cats: clinical and mycological assessment of 29 cases and evaluation of treatment using orally administered fluconazole.: J Med Vet Mycol. 1992;30(2):133-44. Unique Identifier : AIDSLINE MED/92269068; Malik R; Wigney DI; Muir DB; Gregory DJ; Love DN; Department of Veterinary Clinical Sciences, University of Sydney,; NSW, Australia.; Twenty-nine cats with naturally occurring cryptococcosis were evaluated prior to commencing oral fluconazole therapy (25-100 mg every 12 h). Affected cats ranged from 2 to 15 years-of-age. Male cats (19; 66%) and Siamese cats (5; 21%) appeared to be over-represented in comparison to the hospital s cat population. Myco
A 2-year follow-up of an anti-HIV immune reaction in HIV-1 gp160-immunized healthy seronegative humans: evidence for persistent cell-mediated immunity.: J Acquir Immune Defic Syndr. 1992;5(6):539-46. Unique Identifier : AIDSLINE MED/92269105; Picard O; Achour A; Bernard J; Halbreich A; Bizzini B; Boyer V; Desgranges C; Bertho JM; Lachgar A; Polliotti B; et al; Hopital Saint Antoine, Paris, France.; The first trial of an anti-HIV immunization, using a recombinant vaccinia virus expressing gp160 (rV) for priming and paraformaldehyde-fixed rV-infected PBLs and soluble gp 160 for boosting, clearly showed an in vitro HIV-protective immune reaction. This result led us to carry out an additional 2 year Phase I clinical
Changes in AIDS incidence trends in the United States.: J Acquir Immune Defic Syndr. 1992;5(6):547-55. Unique Identifier : AIDSLINE MED/92269106; Green TA; Karon JM; Nwanyanwu OC; Division of HIV/AIDS, Centers for Disease Control, Atlanta,; Georgia 30333.; Estimating the current prevalence of human immunodeficiency virus (HIV) and projecting the future incidence of AIDS require that trends in incidence be analyzed and interpreted. We analyzed AIDS incidence trends in the United States by exposure category and selected demographic factors
Sexual behavior and risk factors for HIV infection in a group of male factory workers who donated blood in Harare, Zimbabwe.: J Acquir Immune Defic Syndr. 1992;5(6):556-9. Unique Identifier : AIDSLINE MED/92269107; Bassett MT; Latif AS; Katzenstein DA; Emmanuel JC; Department of Community Medicine, University of Zimbabwe, Harare.; Zimbabwe has experienced a rapid rise in HIV seroprevalence in recent years. As many as 1 million people (10% of the population) are predicted to become seropositive by 2000. We examined social and behavioral factors associated with HIV infection in a case-control study among mal
HIV antibody testing in France: results of a national survey.: J Acquir Immune Defic Syndr. 1992;5(6):560-4. Unique Identifier : AIDSLINE MED/92269108; Quenum B; Guiguet M; Wells J; Valleron AJ; Centre Cooperateur de Donnees sur l'Epidemiologie de; l'Immunodeficience Humaine, INSERM SC4 Paris, France.; Data from a knowledge, attitudes, and behavior survey conducted at the end of 1988 suggest that 13% of the population in France , aged 16 to 50 years, had been tested for HIV antibodies. Geographical differences in testing were observed, with a greater number of respondents tested i
Ten-year follow-up of HIV-infected homosexual men with lymphadenopathy syndrome: evidence for continuing risk of developing AIDS.: J Acquir Immune Defic Syndr. 1992;5(6):565-70. Unique Identifier : AIDSLINE MED/92269109; Kaplan JE; Spira TJ; Fishbein DB; Lynn HS; Division of Viral and Rickettsial Diseases Centers for Disease; Control, Atlanta, Georgia 30333.; Seventy-five homosexual men with lymphadenopathy syndrome (LAS), subsequently shown to be seropositive for the human immunodeficiency virus (HIV), were enrolled in a prospective study in Atlanta in 1982 and 1983. Subjects have been followed up at 3- to 6-month intervals with clinical and immunologic evaluations, inclu
Cooperativity of neutralizing antibodies directed against the V3 and CD4 binding regions of the human immunodeficiency virus gp120 envelope glycoprotein.: J Acquir Immune Defic Syndr. 1992;5(6):591-9. Unique Identifier : AIDSLINE MED/92269113; Thali M; Furman C; Wahren B; Posner M; Ho DD; Robinson J; Sodroski J; Division of Human Retrovirology, Dana-Farber Cancer Insti