Capitol Heights, MD : National AudioVisual Center, 1985 1 videocassette (30 min.) : sd., col. ; 1/2 in. + 1 guide Unique Identifier : AIDSLINE AV/9200498A
(Producer) Through the use of dramatic vignettes, in which the camera is the audience, individual victims describe the ways in which they contracted AIDS, and its impact on themselves and their families. The picture ends with an explanation of the only acceptable methods of preventing infection with the HTLV-III (HI
Marshfield, WI : The Network, c1988 1 videocassette (43 min. 40 sec.) : sd., col. ; 1/2 in (Medical education for the 1990s) Unique Identifier : AIDSLINE AV/9200560A
Health Program Washington, D.C. : Congress of the United States, Office of Technology Assessment : For sale by the Supt. of Docs., U.S. G.P.O., 1988-[1990] 6 v. : ill Unique Identifier : AIDSLINE CAT/9204107
Philadelphia : Lippincot ; London ; New York : Gower Medical Pub., c1989 vii, 113 p. : ill (Pocket picture guides) Unique Identifier : AIDSLINE CAT/9203692
Oulu, Finland : Nordic Council for Arctic Medical Research, 1990 38 p. : ill (Arctic medical research, ISSN 0787-5339 ; 49/90, suppl. 3) Unique Identifier : AIDSLINE CAT/9204858
Bethesda, Md. : U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Library of Medicine, Reference Section. ; Washington, D.C. : Sold by the Supt. of Docs., U.S. G.P.O., [1991] viii, 48 p (Current bibliographies in medicine ; no. 91-3) Unique Identifier : AIDSLINE CAT/9204290
New Generation Vaccines. Woodrow GC and Levine MM, eds. New York, Marcel Dekker, p. 741-53, 1990.. Unique Identifier : AIDSLINE ICDB/92678614
Tacket CO; Center for Vaccine Development, Dept. of Medicine, Univ. of; Maryland Sch. of Medicine, Baltimore, MD
AIDS has taxed the abilities of basic scientists, physicians, and epidemiologists, who have described the etiologic agent, clinical spectrum, and modes of transmission. For AIDS vaccine development, gaps in knowledge about both pathogenesis and the protective immune response hinder the design of a vaccine. HIV-1 infec
Int Congress Ser; (925):277-80 1990. Unique Identifier : AIDSLINE ICDB/92679907
Biberfeld P; Nakamura S; Ensoli B; Salahuddin ZS; Barillari G; Parravicini C; Gendelman R; Kaaya E; Gallo RC; Immunopathology Lab., Dept. of Pathology, Karolinska Inst.,; Stockholm, Sweden
Culture conditions were developed recently that permit the continuous in vitro propagation of Kaposi s sarcoma (KS)-derived cells, thus permitting their genomic, phenotypic, and functional characterization. Various phenotypic features appeared most likely to correspond to the characteristic spindle cells usually thoug
The goal of this thesis was to synthesize certain restricted pyrimidine acyclic nucleosides (R(anti)-PANs) and their corresponding C6-PANs for their potential as a source of antiviral agents and to possibly afford insight into the conformation of nucleosides involved in the enzymatic interaction of HSV-TK. Thus, two n
The synthesis and biological evaluation of analogs of two antimitotic natural products were undertaken. Application of a novel manganese(III) acetate oxidation process provided the key step in the synthesis of podophyllotoxin congeners. The syntheses of several A and AB-ring taxol analogs were also accomplished. A tub
In this study the synthesis, structure elucidation and biological evaluation of a number of novel N-hydroxy-N -aminoguanidines were performed. The derivatives were synthesized as Schiff bases by reacting 1-amino-3-hydroxyguanidine tosylate with various benzaldehydes. Benzaldehyde was used as the basic aldehyde in synt
Marino P; Fruttero A; Preatoni A; Bossi B; Ferrigno D; Buccheri GF; Dipartimento di Medicina dell'Universita, Ospedale S. Paolo,; Milan, Italy
Previously, we showed increased serum levels of the IL-2 receptor (sIL-2r) in patients (pts) with lung cancer (Br J Cancer, 1990). The goal of the present study was to evaluate CD expression on resting and activated T cells and to seek a relationship between sIL-2r and
Chiner E; Larramendi CH; Calpe J; Munoz J; Chest and Immunology Sections, Hosp. de la Vila Joiosa-Benidorm,; Spain
Differences between pleural fluid and blood lymphocyte subsets have been scarcely studied. We have evaluated a group of 19 patients with pleural effusion (PE) of diverse etiology (10 transudates [Tr] and 9 exudates [Ex]) according to the Light s criteria. Quantitation of lymphocyte subsets was performed by cell flow c
Second International Symposium on Hodgkin's Disease, October 3-5, 1991, Cologne, Germany, p. 31, 1991.. Unique Identifier : AIDSLINE ICDB/92679728
Nyongo A; Abinya NO; Nyabola J; Univ. of Nairobi, P.O. Box 19676, Nairobi, Kenya
In order to show changes in the Hodgkin s lymphoma (HL) pattern in Kenya after the onset of the AIDS epidemic, a retrospective study was undertaken using Kenya Cancer Registry material. The HL diagnoses made from 1/1/68 to 12/31/87 were reevaluated. There were 685 cases (520 males,
Causes, Cures and Consequences of Lymphoproliferative Diseases--A Symposium to Honor George and Eva Klein. May 9-11, 1991, Omaha, NE, 1991.. Unique Identifier : AIDSLINE ICDB/92679927
Bashir RM; Purtilo DT; No affiliation given
In situ hybridization, using a biotinylated sequence from the internal repeat (IR1) region of Epstein-Barr virus, was performed on two well characterized EBV-infected cell lines, B95-8 (productively infected) and Namalwa (latently infected), and on eighteen formalin-fixed paraffin-embedded primary CNS lymphomas. Ten o
Causes, Cures and Consequences of Lymphoproliferative Diseases--A Symposium to Honor George and Eva Klein. May 9-11, 1991, Omaha, NE, 1991.. Unique Identifier : AIDSLINE ICDB/92679937
Gorm P; Hamilton-Dutoit S; Sandvej K; Lab. of Immunohistology, Aarhus University Hosp.,; Kommunehospitalet, 8000 Aarhus C, Denmark
EBV infection in humans is associated epithelial lesions (nasopharyngeal carcinoma, histologically similar carcinomas in other organs, thymoma, oral hairy leukoplakia) and a number of lymphoproliferative disorders. The latter are mostly B-cell proliferations such as infectious mononucleosis (acute, chronic or fatal ty
Causes, Cures and Consequences of Lymphoproliferative Diseases--A Symposium to Honor George and Eva Klein. May 9-11, 1991, Omaha, NE, 1991.. Unique Identifier : AIDSLINE ICDB/92679942
Shapiro RS; Univ. of Minnesota, Minneapolis, Minnesota, 55455
Epstein-Barr virus (EBV)-associated B cell lymphoproliferative disorder (BLPD) is a recognized complication of primary (congenital) immunodeficiency as well as secondary (acquired or iatrogenic) immunodeficiency such as after organ transplantation, following bone marrow transplantation, and in patients (pts) with AIDS
Sugimura T; Fujiki H; Nagao M; Suganuma M; Shima H; Nakayasu M; Natl. Cancer Center Res. Inst., 1-1 Tsukiji 5-chome, Chuo-ku,; Tokyo 104, Japan
Okadaic acid (OA) is a skin irritant and tumor promoter isolated from croton oil and other sources. NIH3T3 cells that had been transformed morphologically by activated c-raf coding for serine/threonine-kinase or activated c-ret (ret II) coding for tyrosine kinase, were cultured in the presence of 8 ng/ml of okadaic ac
Seventh International Symposium on Cancer Research of the House of the Hungarian Academy of Sciences: Convergences of International Cancer Research. June 12-14, 1991, Budapest, Hungary, p. 15, 1991.. Unique Identifier : AIDSLINE ICDB/92679644
Oroszlan S; United States
The discovery in the early 1980s of human retroviruses, human T-cell leukemia virus (HTLV) and human immunodeficiency virus (HIV), the etiologic agent of adult T-cell leukemia and AIDS, respectively, has brought serious challenges to public health. Worldwide, major efforts are being directed towards controlling virus
Second International Symposium on Hodgkin's Disease, October 3-5, 1991, Cologne, Germany, p. 31, 1991.. Unique Identifier : AIDSLINE ICDB/92679727
Tirelli U; Vaccher E; Bertola G; Serraino D; Boiocchi M; Carbone A; Montardini S; Div. of Medical Oncology, Centro di Rileci Menyo Oncologico, Via; Pedemiat and Occidentale, Aviano, Italy
Since 1986, Gruppo Italiano Cooperativo AIDS e Tumori (GICAT) has been collecting data on malignant tumors in pts with HIV infection. As of March 1991, 85 pts with HD and HIV infection have been observed in Italy . Ninety-two of the pts are males and the median age is 27 yr (range 20
First International Congress on Biological Response Modifiers. March 22-24, 1991, Quebec City, Quebec, Canada, A46, 1991.. Unique Identifier : AIDSLINE ICDB/92679785
Sinkovics JG; Cancer Inst., St. Joseph's Hosp., Tampa, FL
In the mouse, murine and human IFN beta inhibited tumor-induced angiogenesis in species-specific fashion and IFNs alpha, beta, and gamma suppressed lymphocyte-induced angiogenesis without inhibiting replication of tumor cells (Sidky and Borden, Cancer Res 47:5155, 1987). In humans, Hu-r-IFN alpha induced remissions of
Int Congress Ser; (925):333-47 1990. Unique Identifier : AIDSLINE ICDB/92679909
Metcalf D; The Walter and Eliza Hall Inst. of Medical Res., P.O. Royal; Melbourne Hosp., 3050 Victoria, Australia
Each cell division by granulocyte-macrophage precursors has been shown to require active stimulation. Four distinct molecules are associated with this biological activity; the four known colony-stimulating factors (CSFs) are granulocyte (G)-CSF, a relatively selective stimulus for granulocyte formation, macrophage (M)
In Vivo. 1988 Jan-Feb;2(1):67-71. Unique Identifier : AIDSLINE MED/92135557
DeHoratius RJ; Division of Clinical Immunology/Rheumatology, Hahnemann; University, Philadelphia, PA 19102.
LCTA are a heterogenous group of antibodies found in many disease states. The recurring observation is that they are able to modulate immune function in vitro. The exact mechanism of this modulation is unknown, however, alteration of cell surface antigens appears to be important. Recent advances in molecular biologica
In Vivo. 1988 Jan-Feb;2(1):91-4. Unique Identifier : AIDSLINE MED/92135562
Baranski BG; Young NS; Cell Biology Section, National Heart, Lung, and Blood Institute,; Bethesda, Maryland 20892.
Recovery of bone marrow function in aplastic anemia patients treated with immunosuppressive therapy first suggested a role for the immune system in bone marrow failure. High recovery rates in patients treated with immunosuppressive therapy suggested that an immune mechanism may be a final common pathway of marrow fail
In Vivo. 1988 Jan-Feb;2(1):15-8. Unique Identifier : AIDSLINE MED/92135548
Phillips PE; Division of Clinical Immunology, State University of New York; Health Science Center, Syracuse 13210.
In spite of the lack of firm evidence implicating infectious agents, it is still likely that SLE requires an initiating event, probably environmental, and possibly infectious. In the setting of genetically determined perturbations of the immune system, an infectious trigger could be a trivial event clinically, and cou
In Vivo. 1989 Mar-Apr;3(2):61-78. Unique Identifier : AIDSLINE MED/92135627
Schulhafer EP; Verma RS; Department of Allergy and Immunology, Long Island College; Hospital, SUNY, Brooklyn 11201.
AIDS is one of the most perplexing diseases to confront modern medicine today. AIDS will rank just behind accidents, heart disease and cancer as a major cause of potential life lost in the USA by 1991. Over half million AIDS cases are predicted by 1993 in the United States alone. There
Del Pezzo M; De Filippis A; D'Alessio A; Rosiello M; Tosone G; Gulletta E; Dipartimento di Biologia e Patologia Cellulare e Molecolare, II; Facolta di Medicina, Universita degli Studi, Napoli.
The Authors have tested the new Tb-Elisa method to detect specific antibodies, raised against A60 major mycobacterial antigen complex, in patients of groups II, III and IV of CDC classification suffering from acquired immunodeficiency and in HIV-1 negative control subjects. The test results support laboratory diagnosi
Solis Moran CE; Molina Moguel JL; Hospital Regional 20 de Noviembre, ISSSTE.
Ever since its initial outbursts in high-risk groups, AIDS has had an appalling impact within the oncological sphere, since it combines opportunistic pathologies with the occurrence of malignancies caused by loss of defensive cells, thus allowing abnormal or cancerous cells to multiply. This paper conveys some recent
Rev Soc Bras Med Trop. 1990 Oct-Dec;23(4):229-31. Unique Identifier : AIDSLINE MED/92159478
da Silva MV; Batista L; Camargo ED; Leitao PA; Szalkay VG; Rosenthal C; Vaz AJ; de Souza AM; Hospital Emilio Ribas e Instituto Adolfo Lutz, Sao Paulo,; Brasil.
Two patients with concomitant leptospirosis and the acquired immunodeficiency syndrome (AIDS) are reported. In these cases different clinical aspects that can be attributed to simultaneity of these pathologies was not observed.
Rev Hosp Clin Fac Med Sao Paulo. 1990 Sep-Oct;45(5):223-8. Unique Identifier : AIDSLINE MED/92132425
Basile MA; Lopes MH; Yasuda MA; Amato Neto V; Departamento de Doencas Infecciosas e Parasitarias, Faculdade; de Medicina da USP.
The authors reviewed medical literature concerning viral infections potentially hazardous to pregnant health workers. Precautions are suggested specially involving AIDS and cytomegalovirus infection.
In Vivo. 1990 May-Jun;4(3):171-3. Unique Identifier : AIDSLINE MED/92135681
Mencoboni M; Lerza R; Bogliolo G; Flego G; Gasparini L; Pannacciulli I; Istituto Scientifico di Medicina Interna, Universita di Genova,; Italy.
Several antiviral compounds showed a toxicity or hemopoietic progenitor cells, 2 , 3 Dideoxycytidine (ddc) is the most potent drug in vitro against human T cell lymphotropic viruses and is now being tested on patients with AIDS and AIDS-related complex. We studied its toxicity on mouse hemopoietic progenitors. Result
Int J Addict. 1990-91;25(12A):1503-14. Unique Identifier : AIDSLINE MED/92155846
Brown BS; Community Research Branch, National Institute on Drug Abuse,; Rockville, Maryland.
The emergence of AIDS has triggered significant change in drug user treatment practices. The vast majority of programs are involved in some aspects of AIDS prevention counseling, large numbers encourage HIV testing, and an increasing number of programs offer on-site testing. Resources available to drug user treatment
Int J Addict. 1990-91;25(12A):1515-36. Unique Identifier : AIDSLINE MED/92155847
Rawson RA; Matrix Institute on Addictions, Beverly Hills, CA 90211.
The development of the alcoholism and drug addiction/use treatment systems was completely separate. By 1980, the drug addiction/use field had a solid scientific base but was losing momentum as a public priority. The alcoholism treatment system was gaining acceptance and the 28-day hospital was becoming the treatment s
Anticancer Drug Des. 1991 Dec;6(6):521-9. Unique Identifier : AIDSLINE MED/92126175
Morvan F; Rayner B; Imbach JL; Laboratoire de Chimie Bio-Organique, URA 488 du CNRS, Universite; Montpellier II, France.
alpha-Anomeric oligonucleotides are resistant to nucleases and display parallel hybridization with complementary DNA and RNA sequences. Although alpha-DNA/beta-RNA duplexes are not substrates for RNases H, alpha-oligos are able to inhibit translation through a RNase H independent mechanism. alpha-Oligos and their alph
Anticancer Drug Des. 1991 Dec;6(6):531-8. Unique Identifier : AIDSLINE MED/92126176
Iversen P; Department of Pharmacology, University of Nebraska Medical; Center, Omaha 68198-6260.
Phosphorothioate oligonucleotides which contain 35S at each internucleoside linkage have been prepared and employed to evaluate the in vivo pharmacokinetics in mice, rats and rabbits. A single administration of a 27-mer complementary to the rev gene of HIV into adult male rats by either the intravenous or intraperiton
Pell MF; Thomas DG; Whittle IR; National Hospital for Neurology and Neurosurgery, London.
Central nervous system involvement with AIDS is not uncommon. The indications and timing of brain biopsy remains controversial. Stereotactic CT-guided biopsy offers a safe and effective means of establishing a diagnosis in any patient with a cerebral mass lesion and has less morbidity and mortality than freehand biops
English A; Adolescent Health Care Project, National Center for Youth Law,; San Francisco, CA 94104.
Significant numbers of runaway and street youth are at risk for human immunodeficiency virus (HIV) infection. These youth are physically, socially, and psychologically vulnerable and need access to health care and related services. Legal and ethical concerns of consent and confidentiality may limit their access, altho
Luna GC; Mount Zion Hospital and Medical Center, University of California,; San Francisco 94120.
This article discusses adaptational and survival strategies of homeless youth and describes how pilot research, begun in 1982 on these strategies in the western United States , led to additional research and activity focused upon the related international street youth problem. The resul
Cohen E; Mackenzie RG; Yates GL; Division of Adolescent Medicine, Childrens Hospital of Los; Angeles, CA 90027.
In this article, we present data obtained with the psychosocial interview instrument, HEADSS (Home, Education, Activities, Drug use and abuse, Sexual behavior, Suicidality and depression) that was administered to High Risk Youth Clinic clients at their initial visits during a 1-year period. Of the 1,015 new patients,
Goulart M; Madover S; Larkin Street Youth Center, San Francisco, CA 94109.
Larkin Street Youth Center (LSYC) is a multidisciplinary service center for homeless youth in San Francisco. This article describes the strategies developed by the medical clinic at LSYC for the prevention of human immunodeficiency virus infection.
Fang JC; Bodeus M; Burtonboy G; Department of Cell Biology, Beijing Institute for Cancer; Research, China.
The rat-rat hybridoma technique has some definite advantages in the three systems (mouse, rat or human system) currently utilized for monoclonal antibody production. The study on rat-rat hybridoma technique and its application to the productions of monoclonal antibodies against human immunodeficiency virus (HIV) and h
Phipps AR; Clarke JA; South West Thames Regional Burns Unit, Queen Mary's University; Hospital, London.
Large burns continue to pose the problem of providing sufficient autologous skin cover. The experience of this unit using cultured keratinocytes as a substitute for split-skin grafts has been disappointing; at the same time, we have been obliged to abandon human allograft skin from cadavers and other patients because
Eardley I; Fowler CJ; Nagendran K; Kirby RS; Rudge P; Department of Urology, St Bartholomew's Hospital, London.
We report the clinical features, urodynamic results and neurophysiological findings in 6 patients with urinary symptoms related to tropical spastic paraplegia. The widespread nature of the pathological changes within the nervous system result in a complex variety of urodynamic and neurophysiological features.
Richens J; London School of Hygiene and Tropical Medicine, UK.
Donovanosis is a predominantly tropical cause of genital ulcer occurring chiefly in small endemic foci in all continents except Europe. Diagnosis requires the careful collection, staining and examination of smears or biopsies of characteristic genital and, occasionally, extragenital lesions for demonstration of the pa
OBJECTIVE--To determine the adverse psychological implications of referral for colposcopic screening within a genitourinary medicine clinic. DESIGN--Cross sectional survey. SETTING--A colposcopy clinic held within a genitourinary medicine clinic. SUBJECTS--160 consecutive women referred to the clinic were assessed for
Duncan ME; Reimann K; Tibaux G; Pelzer A; Mehari L; Lind I; Department of Bacteriology, University of Edinburgh, Scotland.
OBJECTIVES--To determine aetiological factors associated with the prevalence of gonorrhoea in Ethiopian women to enable subsequent formulation of intervention policies. SUBJECTS--1851 Ethiopian women: 50% symptomatic, 50% asymptomatic. SETTING--Gynaecological outpatient departments, antenatal, postnatal and family pla
Int J Psychiatry Med. 1991;21(4):369-78. Unique Identifier : AIDSLINE MED/92129057
Cohen MA; Aladjem A; Horton A; Lima J; Palacios A; Hernandez I; Lefer J; Mehta P; Metropolitan Hospital Center, New York Medical College, New York.
Our hypothesis was that a one-day survey of all patients hospitalized on Adult General Care would demonstrate a need for expanded addiction services in a municipal teaching hospital in East Harlem. We interviewed 276 patients in Adult General Care on February 16, 1990 to assess whether they abused drugs or alcohol or
Int J Psychiatry Med. 1991;21(4):383-91. Unique Identifier : AIDSLINE MED/92129059
el-Mallakh RS; National Institute of Mental Health, Neuropsychiatric Research; Hospital, Washington, D.C.
Cases of mania associated with acquired immune deficiency syndrome (AIDS) are reviewed in an attempt to elucidate patterns that may be helpful in guiding treatment, determining prognosis, and understanding pathophysiology. Fourteen well-described cases in the English language literature were critically reviewed. Data
Tussey LG; Frelinger JA; Department of Microbiology and Immunology, University of North; Carolina, Chapel Hill 27599-7290.
We have constructed a secreted analogue (sA2) of the human class I molecule HLA-A2. sA2 was affinity purified both in the presence and absence of detergent and the effects of detergent on the magnitude and specificity of A2 binding to solid phase peptides tested. sA2 purified in the presence of detergent and detergent
Coutlee F; Saint-Antoine P; Olivier C; Voyer H; Kessous-Elbaz A; Berrada F; Begin P; Giroux L; Viscidi R; Department of Microbiology and Infectious Diseases, Hopital; Notre-Dame, Montreal, Quebec, Canada.
A convenient assay combining solution hybridization and enzyme immunoassay for DNA-RNA hybrids (polymerase chain reaction-enzyme immunoassay [PCR-EIA]) was developed to detect human immunodeficiency virus type 1 (HIV-1) provirus amplified by the PCR and was compared with oligomer hybridization with 32P-labeled SK19. I
Fonseca K; Anand CM; Provincial Laboratory of Public Health for Southern Alberta,; Calgary, Canada.
Two algorithms for screening sera for antibody to human immunodeficiency virus type 1 were compared for their efficiency in identifying a true-positive sample in a population with heterogeneous risk factors, using the criteria of specificity and positive predictive value (PPV). In the first algorithm, all sera were sc
Bessesen MT; Wang E; Echeverria P; Blaser MJ; Disease Control Service, Denver Health and Hospitals, Colorado; 80204.
A strain of enteroinvasive Escherichia coli was isolated from the blood of a patient with advanced human immunodeficiency virus disease on repeated occasions, associated with severe diarrheal illness. The isolate was killed in vitro by control sera but not by sera collected from the patient before or after his bacteri
Kitada K; Oka S; Kimura S; Shimada K; Serikawa T; Yamada J; Tsunoo H; Egawa K; Nakamura Y; Department of Tumor Biology, University of Tokyo, Japan.
Pneumocystis carinii is a eukaryotic microbe which causes fatal pneumonia in patients with AIDS. Oligonucleotide primers were used to amplify the 5S rDNA sequence of P. carinii by the polymerase chain reaction (PCR) in various clinical and animal samples. Of 35 independent lung specimens tested, PCR detected the P. ca
J Community Health. 1991 Dec;16(6):287-97. Unique Identifier : AIDSLINE MED/92129688
Joseph KM; Adib SM; Joseph JG; Tal M; School of Public Health, University of Michigan, Ann Arbor 48109.
This paper explores the relationship between risky sexual behavior and issues of gay identity in homosexual men. We identify three main conceptual categories important to gay identity: sexual identity, gay social interaction, and identity development milestones. Each of these categories are analyzed as to their predic
Smith KJ; Skelton HG 3d; Angritt P; James WD; Yeager J; Wagner K; Walter Reed Army Institute of Research, Washington, DC.
Although HIV-infected patients are commonly infected by organisms that require an intact T cell immune system for control or eradication, there are some exceptions. The intracellular pathogen Listeria monocytogenes is one such organism. Listeriosis occurs primarily in neonates, elderly patients, patients on immune sup
Antoni MH; Baggett L; Ironson G; LaPerriere A; August S; Klimas N; Schneiderman N; Fletcher MA; Department of Psychology, University of Miami, Coral Gables,; Florida 33124.
Forty-seven asymptomatic, healthy gay men were randomly assigned to a cognitive-behavioral stress management (CBSM) condition or an assessment-only control group 5 weeks before being notified of their HIV-1 antibody status. Seventy-two hours before and 1 week after serostatus notification, blood samples and psychometr
Reddy MM; McKinley GF; Grieco MH; AIDS Clinical Trials Unit, St. Luke's-Roosevelt Hospital Center,; New York, NY 10019.
Circulating HIV P24 antigen, beta 2-microglobulin, neopterin, soluble CD4, soluble CD8, and soluble interleukin-2 receptor were measured in 13 zidovudine-intolerant patients (8 with ARC and 5 with AIDS) treated with dideoxyinosine (ddI). Measurements were made at baseline and at several intervals during therapy. Mean
Hinkula J; Gilljam G; Wahren B; Department of Virology, National Bacteriological Laboratory,; Stockholm, Sweden.
A mouse monoclonal hybridoma cell line producing IgG 1k to human immunodeficiency virus (HIV-1) gp120 envelope protein was cultured in several systems. A small-scale flask culture was essential for characterizing the culture variables of the hybridoma. A dialysis tubing culture appeared to be an excellent alternative
Watters DA; Bem C; Echun DA; Ahmed A; University Teaching Hospital, Lusaka, Zambia.
A 1-year prospective audit of 2233 operations performed by one general surgical unit in a Central African teaching hospital is presented. In addition to the usual general surgical procedures, operations also included emergency craniotomy, reconstructive surgery for open fractures, and hysterectomy. There were 37 (1.
Robertson PE; Bhate SR; Bhate MS; Royal Scottish National Hospital, Larbert.
At present, there is a lot of concern about the acquired immune deficiency syndrome (AIDS). Efforts are being made to educate the public about AIDS, so that individuals can take precautions against acquiring or transmitting the disease. Many people with a mental handicap may not benefit from the current education camp
Rossanigo PL; Achilli G; Cattaneo E; Gatti S; Okware SI; Manfrin V; Scaglia M; Department of Infectious Diseases, University, IRCCS San Matteo,; Pavia, Italy.
At the end of 1985, when the AIDS epidemic was in its early stages in Uganda , a survey was carried out in a peripheral area of the country. Sera were collected from groups of people, and examined for the presence of HIV infection. The results show a very limited number of positive
Mascellino MT; Iona E; Iegri F; Catania S; Trinchieri V; Oliva P; Amenta L; Reverberi L; Sorice F; Institute of Infectious Diseases, Universita La Sapienza, Rome,; Italy.
HIV infection is thought to exacerbate the virulence of normal saprophytic vaginal microflora. We studied the vaginal ecosystem of HIV patients to detect the quantitative and qualitative variation of vaginal microorganisms. 15 patients (5 with AIDS and 10 with ARC) were investigated. Vaginal candidiasis was more frequ
We report here the extended Phase I testing of d-ala-Peptide-T-amide (Peptide T) in open trial. The drug was given intravenously in doses ranging from 0.1 to 3.2 mg/kg/day to 14 acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC) patients for 12 weeks. Following a 4-week off-drug period, the first
Rev Mal Respir. 1991;8(6):583-6. Unique Identifier : AIDSLINE MED/92132160
Bayle JY; Ducros B; Bejui-Thivolet F; Perol M; Guerin JC; Service de Pneumologie, Hopital de la Croix-Rousse, Lyon.
Systemic cryptococcosis occurs in at least 6% patients with human immunodeficiency virus infection (HIV). The lung infection by cryptococcus neoformans, less frequently observed than meningeal involvement, consists usually in focal parenchymal mycosis. Authors report an apparently isolated pleural cryptococcosis in a
Rev Med Chil. 1990 Jun;118(6):622-8. Unique Identifier : AIDSLINE MED/92132276
Cartier L; Araya F; Castillo JL; Verdugo R; Mora C; Gajdusek DC; Gibbs CJ; Departamento de Ciencias Neurologicas, Hospital Salvador,; Facultad de Medicina, Universidad de Chile.
We screened 140 patients with different neurological diseases for the presence of anti HTLV-1 virus antibodies. ELISA test confirmed with Western Blot analysis was performed in CSF and blood. Positive findings were obtained in 23 out of 52 patients with progressive spastic paraparesis (44%). All patients with multiple
Rev Med Chil. 1990 Jun;118(6):671-4. Unique Identifier : AIDSLINE MED/92132285
Martinez V; Franco C; Sazunic I; Puga M; Bronfman L; Rodriguez C; Departamento de Hemato/Oncologia del Servicio de Medicina,; Hospital San Juan de Dios, Santiago de Chile.
A 51 year old man with acquired immune deficiency syndrome for 2 years developed a chronic leukemia/T cell lymphoma. Anti HTLV-1 antibodies were confirmed by Western Blot. In the last months he developed hypercalcemia and leukocytosis of 130,000. Necropsy confirmed the diagnosis of Leukemia/T cell lymphoma without cut
Sacks LV; Labriola AM; Gill VJ; Gordin FM; Department of Infectious Diseases, Veterans Affairs Medical; Center, Washington, D.C 20422.
A 36-year-old homosexual man who was infected with human immunodeficiency virus presented with a 2-month history of fever and intermittent diarrhea. Stool cultures were negative for bacterial pathogens, ova, parasites, and acid-fast organisms. An initial blood culture became positive after 5 days for a curved, gram-ne
Pedro-Botet J; Maristany MT; Miralles R; Lopez-Colomes JL; Rubies-Prat J; Department of Medicine, Hospital del Mar, Universidad Autonoma; de Barcelona, Spain.
Splenic tuberculosis is an uncommonly considered diagnosis in clinical practice. We report splenic tuberculosis in three patients with AIDS who were admitted to the hospital because of fever and constitutional syndrome. In all of the patients, abdominal sonography and abdominal computed tomography revealed multiple hy
Clark RA; Blakley SL; Greer D; Smith MH; Brandon W; Wisniewski TL; Tulane/LSU AIDS Clinical Trial Unit, Tulane University Medical; Center, New Orleans, Louisiana 70112.
Proof of hematogenous dissemination of Mycobacterium tuberculosis was initially reported in the early 1900s and was noted to be most frequent in patients with miliary tuberculosis. More recently, M. tuberculosis bacteremia has been reported in human immunodeficiency virus (HIV)-infected patients. We describe 13 adult
Cherubin CE; Appleman MD; Heseltine PN; Khayr W; Stratton CW; Department of Pathology, Los Angeles County-University of; Southern California Medical Center.
To reassess the epidemiology and treatment of listeriosis in the United States , we reviewed greater than 120 cases of listeriosis from four medical centers in three geographically separated cities: Los Angeles County-University of Southern California Medical Center (LAC-USCMC); Rush-Pr
Levitz SM; Evans Memorial Department of Clinical Research, University; Hospital, Boston, Massachusetts.
The ecology of Cryptococcus neoformans and the epidemiology of cryptococcosis are reviewed. Two varieties of C. neoformans have been recognized. C. neoformans variety neoformans has been found in nature worldwide, primarily in association with bird droppings, although nonavian sources have also been found. Most cases
Mayaud C; Houacine S; Parrot A; Cadranel J; Akoun G; Service de Pneumologie et de Reanimation Respiratoire, Hopital; Tenon, Paris.
This review paper is divided into three parts. The first two parts are devoted to an analytical description of the clinical, diagnostic, prognostic and therapeutic aspects of the various bronchopulmonary and pleural lesions observed in AIDS. The third part presents an overall view of the main diagnostic and therapeuti
Desfemmes T; Chouaid C; Febvre M; Housset B; Lebeau B; Service de pneumologie, Hopital Saint-Antoine, Paris.
The authors report a case of AIDS in a 77-year old man, 6 years after pneumonectomy for epidermoid lung cancer. They take this opportunity to review the epidemiological, clinical and prognostic characteristics of geriatric AIDS.
Shah I; Thongthai V; Leoprapai B; Mundigo AI; Prasartkul P; Chamratrithirong A; Special Programme of Research, Development and Research Training; in Human Reproduction, World Health Organization (WHO), Geneva,; Switzerland.
People s knowledge and perceptions about AIDS are critical in efforts to combat the further spread of this disease. Using data from a study on Determinants and Consequences of Contraceptive Use Patterns in Thailand , this paper investigates the knowledge and perceptions about AIDS
Anal Biochem. 1991 Aug 1;196(2):302-7. Unique Identifier : AIDSLINE MED/92133742
Toyoshima T; Kimura S; Muramatsu S; Takahagi H; Shimada K; Department of Infectious Diseases, University of Tokyo, Japan.
In order to analyze the efficacy of azidothymidine ( AZT ), it is important to know intracellular concentrations of AZT metabolites. However, it has been impossible to measure intracellular AZT 5 -monophosphate (AZT-MP), AZT 5 -diphosphate (AZT-DP), and
A protein profile has been monitored during human immunodeficiency virus (HIV) infection. The investigation concerned 60 patients suffering from acquired immunodeficiency syndrome (AIDS), 24 asymptomatic HIV-antibody seropositive subjects and 22 healthy HIV-antibody seronegative, individuals voluntary blood donors. Da
Ann N Y Acad Sci. 1991;640:219-23. Unique Identifier : AIDSLINE MED/92133891
Stern Y; Department of Neurology, Columbia University College of; Physicians and Surgeons, New York, New York 10032.
It is now recognized that human immunodeficiency virus (HIV) can directly impact on cognitive function, particularly in patients with AIDS. Whether HIV affects neuropsychologic performance in otherwise asymptomatic seropositive individuals is controversial, and several large studies have not detected performance chang
Naesens L; Balzarini J; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
9-(2-Phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) are selectively inhibitory to human immunodeficiency virus and other retroviruses. We have now investigated the effects of different PMEA and PMEDAP treatment schedules in newborn mice infected with Moloney murine sa
Goldberg D; Morel P; Chatenoud L; Boitard C; Menkes CJ; Bertoye PH; Revillard JP; Bach JF; Department of Rheumatology, Hopital Cochin, Paris, France.
A phase I/II trial of the anti-CD4 monoclonal antibody (mAb) was undertaken in seven rheumatoid arthritis patients in order, (1) to investigate changes in clinical symptoms and possible side effects, and (2) to study the pharmacokinetics and to determine the dose required to achieve saturation of antibody binding site
World Health Forum. 1991;12(3):297-301. Unique Identifier : AIDSLINE MED/92134472
Lewis G; Finlay J; Widdus R; AIDS Unit, UK Department of Health, London, England.
National AIDS programmes of industrialized countries are moving from rapid growth to consolidation. This transition should afford opportunities for strengthening the approaches to AIDS prevention.
World Health Forum. 1991;12(3):302-6. Unique Identifier : AIDSLINE MED/92134473
Magezi MG; TASO, AIDS Support Organization, Kampala, Uganda.
HIV infection has spread at an alarming rate in Uganda and is continuing to do so. Polygamy and other long-standing cultural practices on the one hand, and certain life-styles adopted under Western influence on the other, have done much to make the AIDS epidemic so severe. Women ar
The noma has been rarely seen during these last decades. It is of an infections etiology, primarily affecting malnourished or immunodeficient children. It is easily confused with neoplastic tumors, tuberculosis, mycosis or gangrene ecthyma which may condition errors in treatment with severe undesirable side-effects. I
Kang DH; Davidson RJ; Coe CL; Wheeler RE; Tomarken AJ; Ershler WB; School of Nursing, University of Wisconsin-Madison 53792.
The relation between brain activity and the immune system was evaluated by assessing immune responses in 20 healthy women who manifested extreme differences in the asymmetry of frontal cortex activation. One group showed extreme and stable left frontal activation; the other group showed extreme and stable right fronta
Candotti D; Jung M; Kerouedan D; Rosenheim M; Gentilini M; M'Pele P; Huraux JM; Agut H; Laboratoire de Bacteriologie-Virologie, CERVI, Hopital de la; Pitie-Salpetriere, Paris, France.
Nine isolates of HIV-1 obtained from Congolese AIDS patients were amplified by the polymerase chain reaction (PCR) using primer pairs and oligomer probes derived from the HIV-1 LAV-BRU (BRU) sequence. When compared to BRU, two isolates exhibited a significant decrease of PCR efficiency with a given primer pair. Moreov
Parekh BS; Pau CP; Granade TC; Rayfield M; De Cock KM; Gayle H; Schochetman G; George JR; Laboratory Investigations Branch, Centers for Disease Control,; Atlanta, Georgia 30333.
Western blot (WB) analysis of various strains of HIV-2 indicated that transmembrane glycoprotein (TMP) of HIV-2 exists as trimers. These trimers have molecular weights and electrophoretic mobilities in the region of the major external glycoprotein, gp120, resulting in WB misidentification during diagnosis. A simple an
Kaleebu P; Cheingsong-Popov R; Callow D; Katabira E; Mubiru F; Biryahwaho B; Sempala S; Gilks C; Brindle R; Were JB; et al; Department of Medicine, St Mary's Hospital Medical School,; London, UK.
We compared 1616 sera from HIV-1-infected subjects and matched HIV-negative local controls in Uganda , Kenya and the UK. Sera were screened for specific antibody to HIV-1 p24 Gag and gp120 Env proteins and for p24 antigenaemia. In contrast to the
Flegg PJ; Brettle RP; Robertson JR; Clarkson RC; Bird AG; Regional Infectious Diseases Unit, City Hospital, Edinburgh, UK.
beta 2-microglobulin (beta 2M) levels were measured in 217 Edinburgh drug users to assess their usefulness as a marker for HIV-related disease. Eighty HIV-seronegative drug injectors had significantly higher levels than 100 HIV-seronegative blood-donor controls. Amongst 137 asymptomatic HIV-seropositive drug users, th
Gaughwin MD; Gowans E; Ali R; Burrell C; National Centre for Epidemiology and Population Health,; Australian National University, Canberra, ACT.
Residual HIV-infected blood in needles and syringes is a source of HIV infection. Using radiolabelled blood we have stimulated needlestick injuries and sharing of syringes by intravenous drug users and quantified the volumes of blood which could be transferred to recipients in these situations. Up to 0.75 microliters
Chave JP; David S; Wauters JP; Van Melle G; Francioli P; Department of Internal Medicine, Centre Hospitalier,; Universitaire Vaudois, Lausanne, Switzerland.
Five renal transplant recipients developed Pneumocystis carinii pneumonia (PCP) over a 22-month period, while no cases had been observed over a 5-year period in 114 transplanted patients treated with the same immunosuppressive protocol. All patients were HIV-negative, and no modification in diagnostic techniques for P
Cooper DA; Pedersen C; Aiuti F; Vilde JL; Ruhnke M; Pehrson PO; Clumeck N; Farthing C; Luthy R; Doherty RR; et al; National Centre in HIV Epidemiology and Clinical Research, St; Vincent's Hospital Medical Centre, Sydney, New South Wales,; Australia.
Our objective was to evaluate the efficacy and safety of zidovudine (250 mg every 6 h) alone or in combination with acyclovir (800 mg every 6 h) as treatment for AIDS-related complex (ARC). A double-blind, controlled clinical trial of 6 months therapy was conducted at teaching h
Chapman CJ; Harris JD; Collins MK; Latchman DS; Department of Biochemistry, University College and Middlesex; School of Medicine, London, UK.
To study the effects of regulatory proteins encoded by herpes viruses on the HIV long terminal repeat (LTR) in the presence or absence of HIV-encoded regulatory products, we prepared a proviral construct containing 5 and 3 HIV LTR, but lacking the coding sequences of any HIV proteins. This construct allowed the effe
Saermark T; Kleinschmidt A; Wulff AM; Andreassen H; Magee A; Erfle V; Laboratory for HIV Membrane Biology, Medical Faculty, University; of Copenhagen, Denmark.
Acylation of virus proteins is an important covalent modification which has been shown, in many cases, to be necessary for their normal function. Furthermore, it has been shown that cerulenin, an inhibitor of this process, inhibits formation of vesicular stomatitis virus and Rous sarcoma virus in infected cultures, as
Moreno S; Martinez R; Barros C; Gonzalez-Lahoz J; Garcia-Delgado E; Bouza E; Department of Clinical Microbiology, Hospital General Gregorio; Maranon, Spain.
Pneumonia caused by common pyogenic bacteria occurs frequently in HIV-infected patients. Its clinical presentation has been described as being similar to that seen in non-immunosuppressed hosts but clearly different to that of opportunistic pneumonias. An atypical presentation has rarely been seen. In a 10-month perio
Lindan C; Allen S; Carael M; Nsengumuremyi F; Van de Perre P; Serufilira A; Tice J; Black D; Coates T; Hulley S; Department of Epidemiology and Biostatistics, University of; California, San Francisco 94105.
We examined factors associated with perceived risk of AIDS, behavior change, and HIV infection in a representative sample of 1458 child-bearing urban women in Rwanda , central Africa. Although 68% of women reported only one lifetime partner, and the majority (87%) lived with a husba
Ann Med. 1991 Dec;23(6):615-24. Unique Identifier : AIDSLINE MED/92134748
Niskanen E; Division of Hematology/Oncology, University of Virginia Health; Sciences Center, Charlottesville.
Five primary hematopoietic growth factors have been extensively evaluated in trials in patients with inadequate blood cell formation. Results have convincingly demonstrated that various chronic anemias can be corrected with erythropoietin. Similarly, there is no doubt that granulocyte-macrophage colony-stimulating fac
Brown-Peterside P; Sibbald B; Freeling P; Department of General Practice and Primary Care, St George's; Hospital Medical School, London.
In order to assess the adequacy of learning about the human immunodeficiency virus (HIV) and the acquired immune deficiency syndrome (AIDS) in vocational training for general practice, a postal questionnaire survey was carried out among trainers and their trainees in seven health regions of England and Scotland. A tot
AIDS Educ Prev. 1991 Winter;3(4):293-304. Unique Identifier : AIDSLINE MED/92134938
Adib SM; Joseph JG; Ostrow DG; James SA; Department of Epidemiology, School of Public Health University of; Michigan, Ann Arbor 48109.
Selected sociodemographic, psychosocial, and behavioral variables were used to predict maintenance or relapse in sexual practices over a 1-year interval in a cohort of homosexual men in Chicago. Univariate analyses and multivariate logistic regression were used to define predictive models for safer practices separatel
AIDS Educ Prev. 1991 Winter;3(4):305-12. Unique Identifier : AIDSLINE MED/92134940
Rotheram-Borus MJ; Koopman C; HIV Center for Clinical and Behavioral Studies, New York State; Psychiatric Institute, Columbia University, NY 10032.
Current sexual risk behavior, AIDS knowledge, and beliefs about AIDS prevention were examined among 59 black and Hispanic male adolescents attending a community center for gay and lesbian youth. Most (73%) were sexually active in the last 3 months, with a median of 2.0 partners and with only 21% reporting consistent c
AIDS Educ Prev. 1991 Winter;3(4):313-21. Unique Identifier : AIDSLINE MED/92134941
Henry K; Maki M; Willenbring K; Campbell S; Department of Medicine, St. Paul-Ramsey Medical Center, MN; 55101-2595.
A survey on HIV antibody testing practices was sent to the 200 hospitals in the United States that conduct infectious disease (ID) fellowship training and to all 171 short-term care Minnesota hospitals. Responses were obtained from 124 U.S. ID hospitals (62%) and from 133 (78%) Minneso
AIDS Educ Prev. 1991 Winter;3(4):322-7. Unique Identifier : AIDSLINE MED/92134942
Gerbert B; Maguire BT; Sumser J; Division of Behavioral Sciences, University of California, San; Francisco 94143-0754.
Our nationwide telephone survey conducted in 1988 (n = 2,000) reveals that the public perceives a considerable risk of contracting AIDS during routine transactions in health care settings. In addition to previously noted public concerns about getting infected with the AIDS virus through blood transfusions and blood do
New Image Teen Theatre combines peer education and theatre in an informative and entertaining package. This study was undertaken to assess the effectiveness of New Image Teen Theatre on altering teenagers attitudes, knowledge, and intentions regarding sexual behavior. A total of 143 adolescents between the ages of 13
AIDS Educ Prev. 1991 Winter;3(4):341-52. Unique Identifier : AIDSLINE MED/92134944
Allender J; Senf J; Bauman K; Duffy PR; University of Arizona AIDS Education Projects, Tucson 85716.
The need for improved knowledge and attitudes about HIV infection and HIV-infected clients has been documented, as has the effectiveness of AIDS education programs in affecting change in these characteristics of health care workers. Analyzing a sample of 336 health care providers, the current study assessed the impact
AIDS Educ Prev. 1991 Winter;3(4):353-66. Unique Identifier : AIDSLINE MED/92134945
Corby NH; Wolitski RJ; Thornton-Johnson S; Tanner WM; Long Beach Department of Health and Human Services, CA 90806.
Interviews were conducted with 137 female sex partners of male injection drug users to provide quantitative and qualitative information regarding their AIDS knowledge, attitudes, and specific risk behaviors. Levels of knowledge regarding HIV transmission and prevention were high, with an average of 81.8% correct on a
AIDS Educ Prev. 1991 Winter;3(4):367-75. Unique Identifier : AIDSLINE MED/92134946
Dusenbury L; Botvin GJ; Baker E; Laurence J; Department of Public Health, Cornell University Medical College,; New York, NY 10021.
The purpose of this study was to determine how much young adolescents know about AIDS and AIDS risk and to identify areas of confusion that might serve as important targets of educational intervention. A multiethnic (43% white, 33% black, 18% Latino) sample of 303 seventh-grade students (48% male) in 3 schools in the
New Biol. 1991 Nov;3(11):1063-73. Unique Identifier : AIDSLINE GENBANK/X57455
Adams BS; Leung KY; Hanley EW; Nabel GJ; Howard Hughes Medical Institute, University of Michigan Medical; Center, Department of Internal Medicine, Ann Arbor 48109-0650.
Transcriptional activation of the interleukin-2 receptor alpha (IL-2R alpha) gene in T cells is dependent on a regulatory element that can bind NF-kappa B but differs in sequence and function from the kappa B site of the immunoglobulin (Ig) enhancer. To define the molecular basis of gene-specific regulation by this va
Magura S; Siddiqi Q; Freeman RC; Lipton DS; Narcotic and Drug Research, Inc., New York, NY 10013.
A cohort sample of 93 addicts admitted to methadone maintenance in four clinics was followed-up for one year to determine change, and predictors of change, in cocaine use. Any use of cocaine in the preceding month decreased from 84% of subjects at admission to 66% at follow-up, and mean days of cocaine use per month f
Sorensen JL; Substance Abuse Services-Ward 92, UCSF, San Francisco General; Hospital 94110.
The AIDS epidemic has dramatically affected drug treatment programs, creating both an epidemiological crisis and a psychological one. A paramount question for treatment program staff is how to prevent patients from acquiring or spreading HIV. The health belief model has been useful in generating prevention approaches,
Hagan H; Des Jarlais DC; Purchase D; Reid T; Friedman SR; Tacoma-Pierce County Health Department, WA 98408.
For over a year, the Tacoma Syringe Exchange has been operating in spite of existing drug paraphernalia laws. One hundred fifty-four subjects have been interviewed regarding drug injection practices for the month prior to first use of the exchange and for the most recent month since using the exchange. Statistically s
Sufian M; Friedman SR; Curtis R; Neaigus A; Stepherson B; Narcotic and Drug Research, Inc.
This paper looks at an innovative approach to AIDS risk reduction among intravenous drug users who are not in treatment. The new method utilizes an organizing model that involves the mobilization of drug users to promote risk reduction. This strategy targets the group as well as the individual for change. Standard out
Cohen JB; Department of Medicine, University of California San Francisco.
Women infected with Human Immunodeficiency Virus (HIV) via a sexual relationship with an infected drug using partner are the second largest group of women diagnosed with AIDS in this country. Since 1983, they have been the most rapidly growing subgroup of adults with AIDS, and the increase has been even more rapid amo
Fournier JG; Escaig-Haye F; Grigoriev V; INSERM U.43, Hopital St Vincent de Paul, France.
We describe a procedure for detecting and localizing cellular rRNA and HIV virus RNA, based on in situ hybridization at the ultrastructural level. After contact with ultrathin sections of cells embedded in Lowicry K4M, biotinylated DNA probes yield specific hybrids identified by a colloidal gold immunocytochemistry ma
Bloor M; Leyland A; Barnard M; McKeganey N; MRC Medical Sociology Unit, Glasgow University.
This paper outlines a new method we have developed for estimating the prevalence of streetworking prostitution and the proportions of female street-working prostitutes who are injecting drug users. This method is based on the capture/recapture approach and involves distinguishing new fieldwork contacts from repeat fie
Kelly B; Dunne M; Raphael B; Buckham C; Zournazi A; Smith S; Statham D; Department of Psychiatry, University of Queensland, Princess; Alexandra Hospital, Woolloongabba, Australia.
This paper examines patterns of psychological adjustment in a small sample of asymptomatic HIV antibody positive men. Comparison is made with data available on male cancer patients. HIV positive men reported greater degrees of anxious preoccupation and hopelessness, and lower levels of the more adaptive fighting spir
Dev Biol Stand. 1991;73:233-41. Unique Identifier : AIDSLINE MED/92137504
Ginnaga A; Morokuma K; Furukawa S; Shigaki T; Katsuki N; Aihara K; Oka T; Sakoh M; Tamura C; Imaizumi A; Chemo- Sero- Therapeutic Research Institute, Kumamoto, Japan.
The heat-treated apoceruloplasmin (Apocp) is a useful protein as an affinity ligand for the purification of pertussis toxin (PT). The amounts of Apocp in the purified antigens or the pertussis component vaccine were determined. Anti-Apocp antibodies were not detected by the passive cutaneous anaphylaxis (PCA) test in
Indian J Med Res. 1991 Sep;93:277-9. Unique Identifier : AIDSLINE MED/92137957
Seth P; Sharma UK; Department of Microbiology, All India Institute of Medical; Sciences, New Delhi.
Peripheral blood mononuclear cells (PBMC) from 13 asymptomatic healthy human immunodeficiency virus type-1 (HIV-1) antibody positive prostitutes from Tamil Nadu, southern India , were cocultivated with phytohemagglutinin stimulated PBMC from HIV antibody negative donors for HIV isola
Li LX; Xu LD; AIDS Research Project, School of Medicine, Wright State; University, Dayton, OH 45401.
The epidemic of acquired immune deficiency syndrome (AIDS) and its causative agent, the human immunodeficiency virus (HIV), are serious and spreading. In response to the epidemic, a variety of intervention and prevention programs have been instituted. In such AIDS intervention and prevention (AIP) activities, the role
Nagai H; Kinoshita T; Imamura J; Murakami Y; Hayashi K; Mukai K; Ikeda S; Tobinai K; Saito H; Shimoyama M; et al; Virology Division, National Cancer Center Research Institute,; Tokyo.
Abnormalities of p53 mRNA in adult T-cell leukemia (ATL) were analyzed using reverse transcription-polymerase chain reaction-single strand conformation polymorphism analysis. Mutations were present in two of 12 ATL patients studied, but not in 3 cell lines immortalized by human T cell leukemia virus type 1 (HTLV-1) in
Lehr HA; Zimmer JP; Hubner C; Reisinger EC; Kohlschutter A; Schmitz H; Department of Virology, Bernhard Nocht Institute for Tropical; Medicine, Hamburg, Germany.
Cytopathogenicity of HIV and other enveloped viruses is reduced by membrane fluidizing agents and by dextran sulphate (DS). To investigate whether DS exerts its antiviral action via plasma membrane fluidization of host cells, we performed anisotropy measurements on human peripheral blood lymphocytes (PBL) using the fl
Coker RJ; Murphy SM; Harris JR; Department of Genito-Urinary Medicine, St Mary's Hospital,; Paddington, London, UK.
Three patients with AIDS who had cryptococcal meningitis were treated with liposomal amphotericin B after unsuccessful treatment with fluconazole and conventional amphotericin B. One patient responded but relapsed nine weeks later; he responded to a second course of treatment but again relapsed and subsequently died.
Ihara Y; Nobukuni K; Namba R; Kamisaka K; Kibata M; Kajinami K; Fujita H; Mabuchi H; Shirabe T; Ohshima K; et al; Department of Neurology, National Minamiokayama Hospital,; Okayama, Japan.
A study is presented of a 48-year-old female patient and her three siblings with familial hypercholesterolemia. The family members had episodes of cerebral infarction and apparently had atherosclerosis of the internal carotid artery, but no coronary heart disease due to their almost normal level of cholesterol. The la
Kira J; Fujihara K; Itoyama Y; Goto I; Hasuo K; Department of Neurology, Faculty of Medicine, Kyushu University,; Fukuoka, Japan.
Magnetic resonance imaging (MRI) of the brain was studied in 35 patients with HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP), 19 HTLV-I seropositive carriers without HAM/TSP (non-HAM/TSP carriers), 18 patients with HTLV-I seronegative spastic spinal paraparesis (SSP), and 82 HTLV-I seronegative
Two unusual cases of cerebral toxoplasmosis in AIDS patients are presented. Two homosexual males aged 33 and 52 years in CDC stage IV C1 complained of memory loss during the past 6 months, as well as weight loss and mild fever. They showed severe intellectual deterioration and discrete basal ganglia dysfunction. Motor
Fukushima Y; Okuyama K; Komuro K; Ueda M; Fukutake K; Fujimaki M; Department of Blood Products, Tokyo Medical College.
One hundred hemophilia A and 30 hemophilia B patients who had been treated with non-heated and heated factor VIII or prothrombin complex concentrates were examined by immunological tests including Clq-bearing immune complexes assay. Antibodies to human immunodeficiency virus type 1 (HIV-1), hepatitis B virus (HBV), he
Nishimura Y; Yoshiki K; Yamaguchi K; Kiyokawa T; Takatsuki K; Blood Transfusion Service, Kumamoto University Medical School.
Dr Kira et al. (Lancet 1991, 338: 64-65) stress the high incidence of the co-infection with HTLV-I and HTLV-II in the HTLV-I associated myelopathy or tropical spastic paraparesis (HAM/TSP) detected by a polymerase chain reaction (PCR). They showed that 67% of HAM/TSP patients and 6% of healthy carriers had the co-infe
Morio S; Soda K; Hashimoto S; Fukutomi K; Nakayama H; Department of Hygiene, Faculty of Medicine, Tottori University.
In Japan , the AIDS (Acquired Immunodeficiency Syndrome) epidemic among haemophiliacs has been the most urgent issue, because of the large number of haemophiliacs with AIDS. However, after governmental approval of the production of heated coagulating agents in 1985 and 1986, the prim
The purpose of this study was to determine the values of freshman nursing students and to determine changes each year over the four years of the study and to provide base data for curriculum and student guidance. The sample consisted of the freshman students who entered college of nursing from 1988 through 1991. The t
Sugata F; Aoki N; Shioda T; Hayashi T; Shimada K; Mitamura K; Shibuta H; Department of Infectious Diseases, University of Tokyo, Japan.
We examined mouse immune response to 4 kinds of recombinant vaccinia viruses carrying the HIV gag gene, including vac-gag/pol, which produces HIV-like particles with processed gag proteins; vac-gag, which also produces HIV-like particles but with unprocessed gag protein; and vac-gag-pol-fuse and vac-es-gag/pol, neithe
Med Hypotheses. 1991 Oct;36(2):114-7. Unique Identifier : AIDSLINE MED/92140251
Hegde HR; Department of Pediatrics, University of Calgary, Alberta, Canada.
Human immunodeficiency virus, the retrovirus associated with acquired immunodeficiency syndrome, is known to deplete CD4+ helper cells and reduce CD8+ cytotoxic cell activity, resulting in impaired cell-mediated immunity and a state of anergy . This leads to dissemination of micro-organisms that are normally held dor
Lombardi V; Carrillo MG; Alimandi M; Boxaca M; Rossi P; Libonatti O; Department of Immunology, Karolinska Instituet, Stockholm,; Sweden.
We conducted a survey using serology and polymerase chain reaction assays to detect HIV 1 and/or HTLV-I antibodies and viral DNA, respectively, in 113 intravenous drug abusers and in 62 sexually active high risk individuals attending two Drug Addict Centres and a Centre for Venereal Diseases in Buenos Aires,
Chandler MR; Department of English, Mills College, Oakland, California 94613.
Over the past 10 years the AIDS crisis has produced a large volume of writing. Much of this is documentary. Dozens of studies of AIDS from various clinical and political perspectives have been complemented by just as many published diaries, autobiographies, novels, plays, and poems. A few of these works have risen to
Radiol Med (Torino). 1991 Nov;82(5):609-12. Unique Identifier : AIDSLINE MED/92141454
Cornalba G; Damiani G; Mariani P; Dedivitis G; Orlando G; Cargnel A; Servizio di Radiodiagnostica, Ospedale L. Sacco, Milano.
Mycobacterial infections can be found in 10% of AIDS patients. Seventy cases with HIV+ infection were examined: they exhibited clear alterations of the chest and contemporaneous isolation and identification of mycobacteria. Primary tuberculosis is the most frequent manifestation in these patients. Alveolar parenchymal
Santos Gil I; Garcia Polo I; del Arco Galan C; Martinez Garcia MC; Noguerado Asensio A; Servicio de Medicina Interna-Infecciosas, Hospital de la; Princesa, Madrid.
Within the numerous complications of AIDS, we want to point out the appearance of inadequate ADH secretion syndrome (IADHSS) in 9 out of; patients, which constitutes a higher percentage than in the general population. In all cases IADHSS was associated to lung or central nervous system pathology. In one patient, IADHS
Ibanez Martinez J; Bautista Ojeda MD; Saez Torres C; Jorda i Heras M; Ayerza Lerchundi MA; Pachon Diaz J; Servicio de Anatomia Patologica, Hospital Regional de Malaga.
We revised 6,863 protocols of clinical autopsies in four hospitals of the Andalusian Health Service, from 1973 to 1988, out of which 2,814 were valid, and finding 81 active tuberculosis cases (TBC) (2.87%), in 53 males and 28 females, with mean age of 54.41 years. Milliar forms (44 cases) predominated over non-milliar
We here present the clinical cases of two homosexual patients, carriers of human immunodeficiency virus (HIV), who later presented a syphilis infection and who after receiving the usually recommended treatment, suffered a relapse of the infection six months afterwards, with neurologic involvement in one case. The clin
Pestre P; Milandre L; Farnarier P; Gallais H; Service des Maladies Infectieuses, Hopital La Conception,; Marseille.
Three HIV seropositive patients presented with cerebral toxoplasmosis which was treated by anti-infectious agents. After partial improvement, they developed hemichorea related to striatal infectious lesions. In AIDS patients with cerebral toxoplasmosis, autopsy series have reported a high incidence of basal ganglia ab
Banfi G; Pirali A; Locatelli M; Murone M; Bonini PA; Laboratorio Analisi, Istituto Scientifico S. Raffaele, Milano,; Italy.
A new tumor marker, tumor-associated trypsin inhibitor (TATI), was studied in 5 patients who received successful kidney or pancreas grafts and in 30 subjects with antibodies against human immunodeficiency virus. Serum TATI concentrations were very high during the four first days after transplantation. Thereafter the s
Preiss DU; Eberspacher B; Abdullah D; Rosner I; Department of Anesthesia, Benedikt Kreutz Rehabilitation Center,; Bad Krozingen, FRG.
The risk of infection after application of vapour heated prothrombin complex concentrate PROTHROMPLEX S-TIM 4 (PCC) was investigated in patients undergoing cardiovascular surgery. The study was conducted according to the recommendations of the International Committee on Thrombosis and Hemostasis (ICTH) with the except
Ther Drug Monit. 1991 Jul;13(4):325-31. Unique Identifier : AIDSLINE MED/92142150
Stretcher BN; Pesce AJ; Murray JA; Hurtubise PE; Vine WH; Frame PT; Department of Pathology, University of Cincinnati School of; Medicine, Ohio.
Zidovudine (ZDV) elicits its antiviral effect through intracellular metabolism to the 5 -triphosphate, which interferes with viral replication. Monitoring of the active metabolites of ZDV in cells could lead to an intracellular therapeutic range. This study was performed to determine whether a radioimmunoassay, previo
Gilmore TD; Department of Biology, Boston University, MA 02215.
A newly described family of transcriptional regulatory proteins, the Rel family, has recently been the subject of much interest. The Rel family includes proteins known to be important in Drosophila development, replication of HIV-1, oncogenesis and general transcriptional control. Nevertheless, there is still much to
Strannegard O; Central Microbiological Laboratory of the Stockholm County; Council, Sweden.
For the laboratory diagnosis of HIV infection antibody assays with unprecedented sensitivity and specificity have been developed. In combination with proper confirmatory tests, these assays enable an accurate diagnosis of HIV infection to be made in almost all cases. In special cases, most notably during very early in
Hill JA; Department of Obstetrics, Gynecology and Reproductive Biology,; Brigham and Women's Hospital, Harvard Medical School, Boston,; Massachusetts 02115.
Vet Immunol Immunopathol. 1991 Nov;30(1):19-30. Unique Identifier : AIDSLINE MED/92142480
Dohms JE; Department of Animal Science and Agricultural Biochemistry,; University of Delaware, Newark 19717-1303.
Immunosuppresive disease is a major economic concern in domestic poultry production. Although many immunosuppressive agents have been described, mechanisms of how infectious and noninfectious agents compromise the immune system are poorly understood in avian species. Two categories, generalized and antigen-specific im
Acta Med Okayama. 1991 Dec;45(6):445-9. Unique Identifier : AIDSLINE MED/92142788
Takahashi I; Sano M; Okamoto H; Shiromoto M; Nakamura T; Ueno K; Nakada H; Haruta Y; Seto T; Yamashita J; et al; Department of Medicine, Kochi Municipal Central Hospital, Japan.
A 34-year-old woman infected with human T cell leukemia virus type-I(HTLV-I) with recurrent thrombocytopenia and various autoantibodies is described. The platelet counts fluctuated between 1.3 x 10(4)/microliters and 14.8 x 10(4)/microliters without any medical treatment, and thrombocytopenia improved with a decrease
Pauza CD; Department of Pathology and Laboratory Medicine, University of; Wisconsin Medical School, Madison 53706.
We have presented data supporting the view that HIV infection of T cells and monocytes proceeds via receptor-mediated endocytosis. Biochemical analysis of the pathway for internalization of 32P-labeled HIV revealed the presence of intact, intercellular virions and provided evidence for subsequent uncoating of these pa
Doms RW; Earl PL; Moss B; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892.
The envelope (env) glycoprotein of human immunodeficiency virus 1 (HIV-1), initially synthesized as a precursor molecule termed gp160, is cleaved into two noncovalently associated subunits prior to delivery to the plasma membrane. We have studied the oligomeric structure of this protein using chemical cross-linking, v
Herranz R; Castro-Pichel J; Garcia-Lopez MT; Perez C; Balzarini J; De Clercq E; Instituto de Quimica Medica, C.S.I.C., Madrid, Spain.
5 -N-(alpha-Amino-beta-mercaptoacyl)amino-5 -deoxynucleosides have been synthesized by coupling of N-formylthiazolidines derived from D- and L-penicillamine, and D- and L-cysteine to 5 -amino-5 -deoxynucleosides using the DCC/HOSu method, followed by deprotection in N HCl in MeOH under argon. Although these compounds
Aszalos A; Chadha KC; Stadler I; Ambrus JL Jr; Ambrus JL; Division of Research and Testing, Food and Drug Administration,; Washington, D.C. 20204.
We have described a nonantibody type inhibitor of interferons (IFN) in the blood of patients with AIDS, advanced neoplastic disorders, and lupus erythematosus in earlier reports (1,2). In the present study we show that the semipurified inhibitor blocks the antiproliferative signal of IFN-alpha in Daudi cells and the m
Schwartsmann G; Sprinz E; Kronfeld M; Vinholes J; Sander E; Zampese M; Preger R; Kalakun L; Brunetto AL; AIDS and Oncology Unit, Hospital de Clinicas de Porto Alegre,; Universidade Federal do Rio Grande do Sul, Brazil.
Antitumour activity of cytotoxic agents, evaluated in patients with AIDS-related Kaposi s sarcoma (KS), is about 30-80%. However, responses are mostly partial and short. Experience with etoposide is similar. Teniposide has a longer elimination half-life and superior antitumour activity compared with etoposide in some
Ioannidis P; Classon B; Samuelsson B; Kvarnstrom I; Department of Organic Chemistry, Arrhenius Laboratory, Stockholm; University, Sweden.
Ammonium [1-(3 ,5 ,6 -trideoxy-beta-D-erythro-hexofuranosyl)thymine]-6 - phosphonate (1), ammonium 3 ,5 -dideoxycytidine-5 -C-methylphosphonate (2) and 3 ,5 -dideoxyadenosine-5 -C-methyl phosphonic acid (3) have been synthesized and tested for anti-HIV activity. The key steps involved an Arbuzov reaction between triet
Sabatino D; Martinez S; Young R; Balbi H; Ciminera P; Frieri M; Department of Pediatrics, Nassau County Medical Center, East; Meadow, New York 11554.
The case of a 7-year-old girl with acquired immunodeficiency syndrome treated for 5 years with AZT and intravenous gamma globulin is reported. Shortly before her demise she developed a pulmonary leiomyosarcoma and leiomyoma. Does prolonged survival in
Int J Legal Med. 1991;104(5):251-4. Unique Identifier : AIDSLINE MED/92144422
Trubner K; Polywka S; Puschel K; Laufs R; Institut fur Rechtsmedizin, Universitat-Gesamthochschule-Essen,; Federal Republic of Germany.
Needle sharing among drug addicts leads to the transmission of infectious diseases such as hepatitis B and AIDS. After development of a test system based on gene technology against the hepatitis C virus (HCV), drug addicts have been regarded as an important reservoir for hepatitis C. In our study 113 (40.1%) out of 28
During the past decade a wide span of heterogeneity has been demonstrated for human papillomaviruses (HPVs), and some basic properties of the HPV genome have been revealed. The use of hybridization assays for HPV DNA detection in infected epithelia, and the recent introduction of synthetic HPV peptides for detection o
Radcliffe KW; Daniels D; Evans BA; Department of Genitourinary Medicine, Charing Cross Hospital,; London, UK.
Perigenital molluscum contagiosum in adults is recognized as being a sexually transmitted infection. A retrospective casenote review was performed on patients attending a department of genitourinary medicine (GUM) who had been diagnosed as having molluscum. One or more co-existent sexually transmitted diseases (STD) w
Shahmanesh M; Bradbeer CS; Edwards A; Smith SE; Department of Genitourinary Medicine, St Thomas' Hospital,; London.
Autonomic function tests have been recorded in 40 male homosexual patients with serum antibodies to human immunodeficiency virus (HIV) and 12 male homosexuals without such antibodies. Abnormalities of autonomic function were found in 15 of 31 patients without other recognized reasons for autonomic dysfunction. Four pa
Romanowski B; Sutherland R; Love EJ; Mooney D; Sexually Transmitted Disease Control, Alberta Health, Edmonton,; Canada.
An outbreak of 1089 cases of infectious syphilis (primary, secondary and early latent) which occurred in the province of Alberta from 1981 to 1987 was analysed by stage of disease, age, sex, sexual preference and geographic distribution. The majority of cases occurred between 1983 and 1985 inclusive. Men accounted for
Ramstedt K; Giesecke J; Forssman L; Granath F; Department of Dermato-Venereology, University of Goteborg,; Sweden.
Models for the spread of sexually transmitted diseases, including AIDS, rely on sexual partner mixing patterns in the population. From data acquired through partner notification for infection with Chlamydia trachomatis among young people in Gothenburg, Sweden , it was possible to co
Nkya WM; Gillespie SH; Howlett W; Elford J; Nyamuryekunge C; Assenga C; Nyombi B; Northern Zone Reference Centre for Parasitic and Infectious; Diseases, Kilimanjiro Christian Medical Centre, Moshi, Tanzania.
Sexually transmitted diseases are thought to be important in facilitating transmission of HIV in sub-Saharan Africa. This study reports the prevalence of several sexually transmitted diseases in 106 prostitutes in Arusha and Moshi Northern Tanzania . The seroprevalence of HIV was
Murphy M; Misquito N; Pomeroy L; Mulcahy F; Department of Genitourinary Medicine, St James's Hospital,; Dublin.
Between January 1987 and December 1990, 179 patients (131 men, 48 women) infected with human immunodeficiency virus type 1 (HIV-1) were admitted 408 times to St James s Hospital, Dublin. One hundred and thirty-two (73.7%) patients were intravenous drug users. The commonest cause of admission was bacterial lower respir
Rogstad KE; Department of Genitourinary Medicine, Leicester Royal Infirmary,; UK.
One thousand consecutive attenders at a Department of Genitourinary Medicine (GUM) completed an anonymous questionnaire to assess the GUM services and provide suggestions for improvement. The replies showed patient preferences to be for an appointment system (68%), separate waiting rooms (84% women, 57% men) and to se
Kumar B; Ross MW; Department of Dermatology, Postgraduate Institute for Medical; Education and Research, Chandigarh, India.
A comparison of sexual activities in 49 homosexually active northwest Indian men attending STD clinics was made with 173 homosexually active Australian men from a community sample. There were major differences between the two on frequency of marriage and of bisexual behaviour (significantly higher in the Indian sample
An Med Interna. 1991 Dec;8(12):582-6. Unique Identifier : AIDSLINE MED/92144839
Gabriel Botella F; Balaguer Martinez JV; Labios Gomez M; Vera Sempere G; Manzanera Escarti R; Garcia Fuster MJ; Servicio de Medicina Interna, Hospital Clinico Universitario,; Valencia.
We present twelve cases of Pneumocystis Carinii Pneumonia (PCP) hospitalized at the Internal Medicine Service of the Hospital Clinico de Valencia between 1989 and 1990. All patients were infected by HIV-1, with ages between 25 and 32 years, with circulating CD4 lymphocytes lower than 25% or 200 cells per cubic millime
Hampton KK; Makris M; Kitchen S; Preston FE; Department of Haematology, Royal Hallamshire Hospital, Sheffield,; UK.
We have studied the potential thrombogenicity of two different heat-treated prothrombin complex concentrates (PCC) in patients with Haemophilia B. Seven patients were studied on nine separate occasions. Four of the patients had chronic hepatitis C (HCV) associated liver disease and three were HIV-antibody positive. Th
Sartori MT; Mares M; Del Mistro A; De Rossi A; Zerbinati P; Girolami A; Institute of Medical Semeiotics, 2nd Chair of Medicine,; University of Padua Medical School, Italy.
Twenty-seven patients suffering from congenital coagulation defects of the prothrombin complex factors were investigated: six had haemophilia B; 14, factor VII defect; four, factor X defect; and three, factor II defect. Nineteen patients (70.3%) had previously received plasma and/or clotting factors concentrates. Amon
Belfort R Jr; de Smet M; Whitcup SM; Pavesio C; Lottenberg C; Rubin B; Lopez JS; Nussenblatt R; Escola Paulista de Medicina, Hospital Sao Paulo-Brasil.
Recent reports suggest that acquired immunodeficiency syndrome (AIDS) patients are at higher risk of developing mucocutaneous reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome (SJS). Resultant dry eye may be further exacerbated by human immunodeficiency virus (HIV) related lacrimal gland dysfun
Jacobson JI; Institute of Theoretical Physics & Advanced Studies for; Biophysical Research, Florida 33458.
Physiologic magnetic fields on the order of magnitude 10(-8) gauss have been unified with their propitiators: quantum genetic particles, the gravitational potential of which is about a few ergs. As these fields are applied to the equations for solenoidal models, B = microNI/L, currents of about a microampere are deriv
Del Mistro A; De Rossi A; Francavilla E; Sartori MT; Chieco-Bianchi L; Istituto di Oncologia, Padova, Italy.
Sera samples from 1134 individuals (824 HIV-1 seropositive and 310 HIV-1 seronegative), collected from January 1988 to April 1990, were tested for HIV-2 antibodies by whole virus assays and synthetic peptide-based assays to determine the prevalence of HIV-2 infection in populations at risk for AIDS in North-East
Tocalli L; Nardi G; Mammino A; Salvaggio A; Salvaggio L; Laboratory of Clinical Chemistry and Microbiology, L. Sacco; Hospital, Milan, Italy.
We reviewed the cases of typhoid fever (3 cases) and non-typhoid salmonellosis (62 cases) diagnosed from 1987 to 1989 in the Laboratory of Clinical Chemistry and Microbiology of the L.Sacco Hospital, Milan. Two cases of typhoid fever and 24 cases of non-typhoid salmonellosis occurred in patients without clinical sym
Portincasa P; Conti G; Gerloni M; Chezzi C; Institute of Microbiology, University of Parma, Medical School,; Italy.
Detection of antibodies to single HIV-1 proteins was performed by modified Western-blotting procedure. The use of [35S]-Streptavidin instead of Avidin-peroxidase conjugate greatly enhances the sensitivity of the method and enables useful quantitative analysis of results.
Perl A; Isaacs CM; Eddy RL; Byers MG; Sait SN; Shows TB; Department of Molecular Medicine and Immunology, Roswell Park; Memorial Institute, Buffalo, New York 14263.
Suzuki Y; Joh K; Orellana MA; Conley FK; Remington JS; Department of Parasitology, Jikei University School of Medicine,; Tokyo, Japan.
Studies were performed in a murine model to determine if there is genetic control of the development of toxoplasmic encephalitis. Ten weeks after infection with the ME49 strain of Toxoplasma gondii, mice with the H-2b haplotype (C57BL/6, C57BL/10) and H-2k haplotype (C3H/He, CBA/J) developed remarkable inflammatory ch
Agbede O; Wahab S; Schutt DL; Lucia HL; Department of Pathology, University of Texas Medical Branch,; Galveston 77550.
One hundred and twenty reactive sera were selected from specimens studied by enzyme immunoassay (EIA, Abbott Laboratories , Abbott Park, North Chicago, IL) for antibodies against human immunodeficiency virus (HIV-1). Using these sera, the WesPage system (American Bionetics, Inc.,
Preston DR; Farrah SR; Bitton G; Chaudhry GR; Department of Microbiology, University of Florida, Gainesville.
Raw wastewaters were obtained from the cities of Belle Glade, Ocala and Gainesville in the state of Florida and were concentrated using several established methods for the recovery of human enteroviruses. The nucleic acids were then extracted from the wastewater concentrates, suspended in 2 x SSC with and without 2 N
Zachar V; Mayer V; Aboagye-Mathiesen G; Norskov-Lauritsen N; Ebbesen P; Danish Cancer Society, Department of Virus and Cancer, Aarhus.
The efficiency of enhanced chemiluminescence based on a novel generation substrate for alkaline phosphatase, adamantyl-1,2-dioxetane phosphate, was compared with that of 32P-labelled probe for visualization of human immunodeficiency virus type 1 (HTV-1)-specific DNA-DNA hybrids. The probe used for nonisotopic detectio
Lipson JM; Brown LT; Department of Psychology, Oklahoma State University, Stillwater.
Three popular videotapes were assessed for their effectiveness in improving knowledge and attitudes about acquired immune deficiency syndrome (AIDS). One hundred forty-four university students completed knowledge and attitude questionnaires and then watched either an AIDS or a control tape. Half the students completed
Masuda G; Negishi M; Ajisawa A; Yamaguchi T; Tajima T; Tamagawa S; Maeda Y; Ohtomo H; Kimata I; Uni S; et al; Tokyo Metropolitan Komagome Hospital.
Case I: A middle-age homosexual male developed AIDS with Pneumocystis carinii pneumonia (PCP) and esophageal candidiasis in 1986 during his stay in an European country about five months prior to transfer to Tokyo Metropolitan Komagome Hospital, Tokyo, in 1987. He was also diagnosed as having cryptosporidiosis presenti
Med Microbiol Immunol (Berl). 1991;180(4):183-92. Unique Identifier : AIDSLINE MED/92149490
Chowdhury IH; Koyanagi Y; Takamatsu K; Yoshida O; Kobayashi S; Yamamoto N; Department of Microbiology, Tokyo Medical and Dental University; School of Medicine, Japan.
CD4 molecule, a surface marker of helper T lymphocytes, interacts with gp120 of human immunodeficiency virus (HIV) with a high affinity and, hence, serves as a virus receptor. Soluble chimeric CD4-immunoglobulin (Ig) possesses anti-HIV activity due to its binding activity to gp120. Furthermore, this recombinant molecu
Worker exposure to bloodborne diseases can be minimized through: . training and education programs; . use of personal protective equipment such as gloves, gowns, face masks and eye protection; . work practices such as thorough hand washing after each patient contact; . proper handling of sharps; . engineering controls
Checchi L; D'Achille C; Conti S; Universita degli Studi di Bologna.
The diffusion of transmissible diseases such as the Acquired Immunodeficiency Syndrome, well known as AIDS, has induced in the population a great sensibility to the problem of disease transmission. Dentists and patients, because of peculiar features of oral environment and dental procedures, are very exposed to these
Mostaza JM; Dominguez A; Garcia Rodejas ME; Barbado FJ; Pena JM; Anton E; Vazquez JJ; Servicios de Medicina Interna y Anatomia Patologica, Hospital; La Paz, Universidad Autonoma de Madrid.
We have reviewed the autopsies performed on 45 AIDS patients who died in our hospital until June 1989, comparing the post-mortem diagnosis with those made while the patient was alive and in his last hospital admission. Bacterial pneumonia, CMV infection and atyp
Although listeria monocytogenes is an opportunistic pathogen, infection by this bacteria is infrequent in AIDS patients. We were describe a case of L. monocytogenes meningitis in a patient infected by the human immunodeficiency virus (HIV). Literature is reviewed, and the pathogenesis of infection by this bacteria and
Carrasco R; Roig P; Salavert M; Nieto A; Medina E; Sanmartin O; Seccion de Enfermedades Infecciosa, Hospital General; Universitario, Valencia.
We present a case of disseminated tuberculosis with peritoneal and intestinal involvement in a homosexual patient who presented micronodular fibrosis and was infected by HIV, with an AIDS diagnosis since he had previously presented an esophagitis caused by candida. Diagnosis was made from a sample obtained from an ulc
Lo SS; de Andrade JC; Condino ML; Alves MJ; Semeghini MG; Galvao E da C; Superintendencia de Controle de Endemias (SUCEN), Sao Paulo,; Brasil.
Cases of induced malaria have been notified in S. Paulo State, Brazil , in recent years. At the same time the number of cases imported from endemic regions of Brazil has been increasing. One case of induced malaria by Plasmodium vivax was registered in Presidente Prudente, located i
de Moura L; Jacquemin A; Departamento de Psicologia e Educacao, Faculdade de Filosofia,; Ciencias e Letras de Ribeirao Preto, Universidade de Sao; Paulo, Brasil.
Psychosocial aspects which arise with regard to people directly or indirectly involved with AIDS: patients, relatives and professional staff, are studied. The results show that the population assisted in the Ribeirao Preto region is predominantly young, male and drug-addicted. The patients with positive results show r
Matsevich GR; Starov AI; Marennikov SS; Andzhaparidze OG
The results of the development and trials of two variants of EIA test system for the detection of HIV-1 antigen using biotinated HIV-antibody and streptavidin-peroxidase or biotin-beta-lactamase enzyme complexes are presented. These diagnostic preparations proved to be highly sensitive and specific allowing the detect
A chronically HIV-1-infected culture of continuous human monocytes producing infectious virus during long-term continuous cultivation (over 200 passages) without the addition of noninfected cells was generated. HIV-1 produced by this culture had typical morphology and complete set of virus-specific proteins. This cell
West Indian Med J. 1991 Dec;40(4):188-92. Unique Identifier : AIDSLINE MED/92151446
Prussia PR; Mansoor GA; Edwards C; Jordan O; Queen Elizabeth Hospital, Barbados.
Two fatal cases of haemophagocytic syndrome diagnosed on the basis of autopsy findings at the Queen Elizabeth Hospital, Barbados , are presented. They were both young patients, a male 20 years of age and a female 28 years of age, with common clinical features of severe constitutio
Foa P; Istituto di Scienze Mediche, Padiglione Granelli, Milano, Italia.
The last few years have seen an enormous increase in our knowledge on the haematopoietic growth factor erythropoietin (Epo), firstly with its purification and determination of its primary amino acid sequence, and more recently with the isolation of the Epo gene and its expression in mammalian cell lines. This review a
Shintaku M; Sasaki M; Senzaki H; Morii S; Maruoka M; Ueda Y; Department of Pathology, Osaka Red Cross Hospital, Japan.
The patient was a 46-year-old male hemophiliac who died of acute mycobacterial meningitis associated with AIDS (acquired immune deficiency syndrome). Autopsy revealed severe basal meningitis which was characterized by an infiltration of numerous polymorphonuclear leukocytes. Severe mural inflammation of the subarachno
Acta Med Port. 1991 Sep-Oct;4(5):263-7. Unique Identifier : AIDSLINE MED/92151808
Gloria H; Ramalho F; Marinho R; Pedro M; Velosa J; Moura MC; Unidade de Hepatologia e Centro de Gastrenterologia (INIC),; Hospital de Santa Maria, Lisboa.
A retrospective analysis of 135 drug addicts followed between 1986 to 1987, was done, in order to asses the seroprevalence of hepatitis B virus (HBV), hepatitis Delta virus (HDV), hepatitis C virus (HCV) and Human Immunodeficiency virus (HIV), as also their clinical and prognostic significance. A high prevalence of HB
Acta Med Port. 1991 Sep-Oct;4(5):273-4. Unique Identifier : AIDSLINE MED/92151811
Patricio F; Gamito AO; Hospital Miguel Bombarda, Lisboa.
Psychotic features resembling those seen in a functional psychosis--Delusional Disorder--were found in a forty two-year-old male eighteen months before a diagnosis of A.I.D.S. was made. The causal relation between the two entities is discussed making reference to five other similar cases described in the literature.
Saito M; Kato K; Kondo A; Miyake K; Department of Urology, Nagoya University School of Medicine.
Bladder dysfunction is one of the major symptomatologies characteristic to HAM (HTLV-I associated myelopathy). Four patients, 3 females and 1 male, were diagnosed by neurologists to have HAM with spastic gait disturbance and increased titer of antibody to HTLV-I. They complained of urge incontinence, bed wetting, diff
Ascensao JL; Bilgrami S; Zanjani ED; Department of Medicine, University of Connecticut School of; Medicine, Farmington.
Erythropoietin is a glycoprotein hormone that plays a vital role in erythropoiesis. It is mainly produced in the fetal liver till the third trimester of pregnancy. At that point, the kidney interstitium takes over this function and becomes the main source of erythropoietin. Hypoxia stimulates erythropoietin production
Pepin J; Morgan G; Dunn D; Gevao S; Mendy M; Gaye I; Scollen N; Tedder R; Whittle H; Medical Research Council Laboratories, Fajara, The Gambia.
Two hundred and forty-one prostitutes working in The Gambia were tested for retroviral infections and their immune system evaluated. Sixty-three were seropositive for HIV-2 only, five for HIV-1 only and six for both HIV-1 and HIV-2 (26.1, 2.1 and 2.5%, respectively). When compared
Scarlatti G; Lombardi V; Plebani A; Principi N; Vegni C; Ferraris G; Bucceri A; Fenyo EM; Wigzell H; Rossi P; et al; Department of Virology, Karolinska Institute, Stockholm, Sweden.
Diagnosis of perinatal HIV-1 infection is complicated by the persistence of maternal antibodies and the conflicting reports on polymerase chain reaction (PCR) reactivity in children born to HIV-1-seropositive mothers. We have compared PCR with other diagnostic methods for perinatal HIV-1 infection and have attempted a
Parekh BS; Shaffer N; Pau CP; Abrams E; Thomas P; Pollack H; Bamji M; Kaul A; Schochetman G; Rogers M; et al; Division of HIV/AIDS, Centers for Disease Control, Atlanta,; Georgia 30333.
Recent reports have suggested that maternal antibodies to specific epitopes of the variable region 3 (V3 loop) of gp120 of HIV-1 might protect against perinatal transmission. In an attempt to confirm these findings, sera from 34 HIV-1-seropositive mothers, representing 13 episodes of mother-to-infant transmission and
Cichutek K; Norley S; Linde R; Kreuz W; Gahr M; Lower J; von Wangenheim G; Kurth R; Paul-Ehrlich-Institut, Langen, Germany.
Peripheral blood mononuclear cells (PBMC) from two haemophilia B patients, who presumably became infected with a putative HIV-1 biological clone following treatment with the same suspected batch of commercial factor, were used to clone and sequence the hypervariable V3 region of the HIV-1 envelope protein. In 10 of 12
Ensoli F; Fiorelli V; Mezzaroma I; D'Offizi G; Rainaldi L; Luzi G; Fiorilli M; Aiuti F; Department of Allergy and Clinical Immunology, University of; Rome, Italy.
It has been reported that the period of latency between HIV-1 infection and the production of antibodies against the virus is sometimes prolonged for greater than 6 months. However, the data supporting this are still controversial and it is not known whether these individuals are actually infectious, especially throug
Lee TH; el-Amad Z; Reis M; Adams M; Donegan EA; O'Brien TR; Moss AR; Busch MP; Irwin Memorial Blood Centers, San Francisco, California 94118.
Evidence of frequent HIV-1 infections in antibody-negative, high-risk individuals (so-called silent infections) remains controversial. To evaluate whether these discrepant results may be the consequence of intermittent detection of rare infected cells (low viral load) preceding seroconversion, we developed a modific
Kokkevi A; Hatzakis A; Maillis A; Pittadaki J; Zalonis J; Samartzis D; Touloumi G; Mandalaki T; Stefanis C; Department of Psychiatry, Athens University Medical School,; Greece.
Neuropsychological findings from investigation of 46 HIV-seropositive asymptomatic and 14 HIV-seropositive symptomatic haemophiliacs without AIDS-related complex (ARC) or AIDS, with known duration of HIV seropositivity were compared with 29 seronegative controls. Subjects were assessed blindly using a battery of sensi
Pulliam L; Herndier BG; McGrath MS; Department of Laboratory Medicine, Veterans Affairs Medical; Center, San Francisco, CA 94121.
A formulated preparation of trichosanthin (GLQ223, Pharmaceutical Development Group, Genelabs Inc., Redwood City, California, USA) has been shown to selectively inhibit HIV replication in vitro in lymphocytes and macrophages. In view of recent anecdotal reports of central nervous system (CNS) complications associated
Batman PA; Miller AR; Sedgwick PM; Griffin GE; Department of Histopathology, St George's Hospital Medical; School, London, UK.
Autonomic nerves in jejunal mucosa of HIV-infected patients show severe structural damage on electron microscopic examination. The aim of this study was to quantify loss of autonomic axons from the lamina propria of HIV-infected patients in different clinical stages of disease. Jejunal biopsies were taken from 19 HIV-
Khoo SH; Blackwell N; Lister Unit for Infectious Diseases, Northwick Park Hospital,; Harrow, UK.
A 30-year-old man with AIDS presented with symptoms of fever, epigastric pain and weight loss, together with histological findings of Helicobacter pylori-induced gastritis. His symptoms resolved with treatment, as indicated by the clearing of his H. pylori infection on repeat gastric biopsy. Although uncommon, H. pylo
Snyder HW Jr; Bertram JH; Henry DH; Kiprov DD; Benny WB; Mittelman A; Messerschmidt GL; Cochran SK; Perkins W; Balint JP Jr; et al; IMRE Corporation, Seattle, Washington 98109-4933.
Thirty-seven HIV-infected homosexual men with thrombocytopenia (less than 100 x 10(9)/l) received protein A immunoadsorption treatments to remove platelet-sensitizing immunoglobulin (Ig) G and circulating immune complexes (CIC) from plasma. Patients received an average of six treatments each, consisting of 250 ml plas
AIDS Care. 1991;3(4):355-61. Unique Identifier : AIDSLINE MED/92153907
Bagnall G; Plant MA; Department of Psychiatry, University of Edinburgh, Morningside; Park, UK.
The results are presented of a survey of HIV/AIDS related risks amongst young adults in two urban areas in Scotland. This exercise elicited data from random samples of those aged 16-30 in Muirhouse and Easterhouse. Muirhouse has a high rate of HIV infection, mainly related to intravenous drug use. Easterhouse has a mu
AIDS Care. 1991;3(4):363-72. Unique Identifier : AIDSLINE MED/92153908
Loxley W; Marsh A; Lo SK; National Centre for Research Into the Prevention of Drug Abuse,; Division of Health Sciences, Curtin University of Technology,; Western Australia.
Young injecting drug users (IDUs) in Australia are a group about whom little is known. It is suggested, however, that their drug using behaviours and life styles put them at particular risk for HIV/AIDS. Data collected in Perth from 195 respondents in the Australian National AID
The clinical and social consequences of AIDS dementia complex/HIV-1 associated cognitive/motor complex (ADC/HACC) in drug users have not been well documented. The value of prospective serial neuropsychological, neuroradiological and neurophysiological measurements to assist diagnos
AIDS Care. 1991;3(4):467-71. Unique Identifier : AIDSLINE MED/92153926
Catalan J; Burgess A; Academic Department of Psychiatry, Charing Cross and Westminster; Medical School, Westminster Hospital, London, UK.
Whilst this conference presented no new or exciting breakthroughs in our understanding of the psychosocial or neuropsychological aspects of HIV disease, there were some useful contributions to our knowledge in these areas. Previous work suggesting that HIV seropositive individuals with HIV are no more likely to suffer
Plasma protein solutions such as albumin and intramuscular immune globulin have long histories of viral safety. Coagulation factor concentrates as traditionally manufactured frequently transmitted HBV, HCV, and HIV. Indeed, it is probable that every vial of concentrate contained infectious HCV. Modern coagulation fact
Bull World Health Organ. 1991;69(6):747-52. Unique Identifier : AIDSLINE MED/92154758
van der Groen G; Van Kerckhoven I; Vercauteren G; Piot P; Department of Microbiology, Institute of Tropical Medicine,; Antwerp, Belgium.
The conventional approach to human immunodeficiency virus (HIV) antibody testing, which relies on confirmation of all initially positive screening results using a Western blot assay, is expensive. In an alternative approach, we retested sera that were positive in an initial screening assay using a second screening ass
Bull World Health Organ. 1991;69(6):753-60. Unique Identifier : AIDSLINE MED/92154759
Van Kerckhoven I; Vercauteren G; Piot P; van der Groen G; Department of Microbiology, Institute of Tropical Medicine,; Antwerp, Belgium.
Summarized are the results of an assessment of the major operational characteristics of 36 commercially available assays for detection of antibodies to human immunodeficiency virus type 1 (HIV-1) and/or type 2 (HIV-2). For this purpose, 20 enzyme-linked immunosorbent assays (ELISAs), 11 simple immunoassays with visual
Suoh H; Sahashi K; Ibi T; Tashiro M; Mitsuma T; Fourth Department of Medicine, Aichi Medical University.
A 65-year-old house-wife developed dirty erythematous rash on her face in April, 1989. Almost simultaneously, she complained of muscle soreness and weakness on both lower extremities. Pathological findings of the skin biopsy at that time was consistent with those of sarcoidosis with moderate inflammatory cell infiltra
Abortion services are provided in hospitals, doctors offices and various types of clinics, but about two-thirds of procedures are performed in specialized abortion clinics. While this system appears to work well for most women, some women seeking abortion face obstacles related to distance, cost, harassment and speci
Int J Addict. 1991 Dec;26(12):1247-61. Unique Identifier : AIDSLINE MED/92155849
Watters JK; Cheng YT; Lorvick JJ; University of California, San Francisco 94109.
We examined the relationship of HIV serostatus to drug use profile, high risk behavior, drug treatment status, and demographic characteristics of 505 intravenous drug users (IVDUs) in San Francisco. We found five identifiable drug-injection profiles described as Omnijector, Primarily Heroin, Primarily Heroin/Cocaine,
Int J Addict. 1991 Dec;26(12):1263-77. Unique Identifier : AIDSLINE MED/92155850
Stimson GV; Lart R; Department of Psychiatry, Charing Cross and Westminister Medical; School, London, England.
Since 1986 there has been a major reconceptualization of drugs policy in England in response to HIV and AIDS with new ideas about risk behavior and risk reduction, and health behavior and harm minimization. The debate appears to have a new public health emphasis, but historical examination shows public health concerns
Int J Addict. 1991 Dec;26(12):1279-92. Unique Identifier : AIDSLINE MED/92155851
Des Jarlais DC; Abdul-Quader A; Tross S; Beth Israel Medical Center, New York, New York.
Intravenous drug users have surprised many policymakers and researchers by exhibiting large-scale AIDS risk reduction. Relapse from desired behavior change has been a traditional problem in treatment for drug misuse/dependence. Failure to maintain AIDS risk reduction was examined in a study of 399 intravenous drug use
Int J Addict. 1991 Dec;26(12):1293-302. Unique Identifier : AIDSLINE MED/92155852
Christensson B; Ljungberg B; Department of Infectious Diseases, University Hospital, Lund,; Sweden.
An HIV prevention project, including syringe exchange, among intravenous drug users was started in Lund, Sweden , in November 1986. The program has been effective in reaching local addicts. Practical problems have been few. The educational and epidemiological effects on HIV infectio
Int J Addict. 1991 Dec;26(12):1303-11. Unique Identifier : AIDSLINE MED/92155853
Buning EC; Drug Department Municipal Health Service, Amsterdam, The; Netherlands.
The needle and syringe exchange in Amsterdam was initiated in 1984 by the Junky Union. To date, ample data are available to support the role of the needle exchange in facilitating drug injectors to use drugs in a safer way: no increase in drug use could be validated, participants of the exchange schemes were less invo
Int J Addict. 1991 Dec;26(12):1313-20. Unique Identifier : AIDSLINE MED/92155854
Vanichseni S; Wongsuwan B; Choopanya K; Wongpanich K; Drug Abuse Prevention and Treatment Division, Bangkok; Metropolitan Administration, Thailand.
This study represents the first controlled trial of methadone maintenance and 45-day methadone detoxification in Thailand . We randomly assigned 240 male heroin addicts with at least six prior detoxification treatment episodes to 45-day detoxification or to methadone maintenance t
Int J Addict. 1991 Dec;26(12):1321-31. Unique Identifier : AIDSLINE MED/92155855
Heckmann W; Department of AIDS Research, Sozialpadagogisches Institut Berlin,; Germany.
These comments on German drug and AIDS policy are based on the author s two decades of experience in the field of drug user treatment, on recent studies about the epidemiology and etiology of HIV among IVDUs, and on evaluative studies on demonstration projects. German drug use/user policy did not change much in the fa
Int J Addict. 1991 Dec;26(12):1333-47. Unique Identifier : AIDSLINE MED/92155856
Pokapanichwong W; Douglas D; Wright NH; Vanichseni S; Choopanya K; Program for Appropriate Technology in Health (PATH) Bangkok,; Thailand.
Prompted by an explosive epidemic of HIV-1 in early 1988 among Thai IVDUs under treatment for heroin use, a series of focus group discussions were conducted at six Bangkok detoxification clinics. In developing qualitative information on knowledge of and attitudes toward AIDS, and on drug use and sexual behavior, our o
Fauvelle F; Leon A; Petitjean O; Guillevin L; Service de Pharmacie Clinique, CHI Montfermeil, France.
Pharmacokinetics of zidovudine (azidothymidine, AZT ) were investigated after oral administration (300 mg every 8 hours) in a human immunodeficiency virus seropositive patient who was also treated with plasma exchange (60 ml/kg). Plasma AZT concentrati
Kerr LD; Spiera H; Department of Medicine, Mount Sinai School of Medicine, New York,; NY 10029.
The lack of previous reports documenting the coexistence of active rheumatoid arthritis (RA) and acquired immunodeficiency syndrome (AIDS) despite an abundance of other HIV associated autoimmune phenomena has generated a hypothesis regarding the necessity of the T4 cell for the development or continued activity of RA.
J Med Ethics. 1991 Dec;17(4):196-8. Unique Identifier : AIDSLINE MED/92157137
Adler MW; University College and Middlesex School of Medicine, London.
The passing on of information to GPs by genito-urinary doctors is to be encouraged but is not always possible and ultimately the patient s wishes and confidentiality must be respected if sexually transmitted diseases and HIV infection are to be controlled. Infected health-care workers should seek counselling and medic
Condelli WS; Fairbank JA; Dennis ML; Rachal JV; Research Triangle Institute, Research Triangle Park, North; Carolina 27709.
Widespread use of cocaine by methadone clients is undermining the effectiveness of methadone treatment programs in reducing illicit drug use, decreasing criminal behavior, and slowing the spread of the human immunodeficiency virus (HIV). In response, methadone programs are implementing a range of behavioral interventi
Kramer TH; Mosely JA; Rivera A; Ottomanelli G; Li PW; Bihari B; Department of Psychiatry, State University of New York, Health; Science Center, Brooklyn.
The need for behavioral change of risky sexual practices has been of the highest priority since the onset of the AIDS epidemic. The major focus of education for safe sex has been emphasis on condom use. We surveyed 124 individuals applying to treatment for various chemical dependencies and 60 individuals applying for
Haverkos HW; Division of Clinical Research, National Institute on Drug Abuse,; United States Public Health Service, Rockville, Maryland 20857.
Several communicable infectious diseases, including AIDS, hepatitis B infection, gonorrhea, syphilis, and tuberculosis, are increasing among drug abusers. Drug abuse treatment programs may be ideal sites to identify those infections and initiate and maintain appropriate medical management. This paper reviews the epide
Ross MW; Caudle C; Taylor J; National Centre in HIV Social Research, School of Community; Medicine, University of New South Wales, Australia.
The AIDS Social Assertiveness Scale (ASAS) and a measure of AIDS knowledge were administered to 490 high school students from 10 South Australian schools selected across a range of public/private, rural/urban, and socioeconomic statuses. Age, grade, hours of AIDS education, and sexual experience (and condom use) also
Med Lab Sci. 1991 Jul;48(3):235-7. Unique Identifier : AIDSLINE MED/92157835
Magee JG; McDade KJ; Cunningham J; Harrison V; Public Health Laboratory, Institute of Pathology, General; Hospital, Newcastle-upon-Tyne, England, UK.
A monoclonal antibody-based immunofluorescence test for the detection of Pneumocystis carinii was evaluated in comparison with the conventional direct staining by Grocott s silver methenamine technique. A total of 254 respiratory samples from HIV positive and other immunocompromised patients were examined. Cysts were
Mod Pathol. 1991 Nov;4(6):707-11. Unique Identifier : AIDSLINE MED/92158994
Washington K; Gottfried MR; Wilson ML; Department of Pathology, Durham Veterans Affairs Medical Center,; North Carolina.
Cryptococcal infection of the gastrointestinal (GI) tract is rarely reported, either in disseminated disease or as an isolated finding. We report a case of gastric cryptococcal infection diagnosed by endoscopic biopsy as the initial presentation of the acquired immunodeficiency syndrome (AIDS), and an additional seven
Mod Pathol. 1991 Nov;4(6):750-4. Unique Identifier : AIDSLINE MED/92159001
Lo SC; Buchholz CL; Wear DJ; Hohm RC; Marty AM; Department of Infectious and Parasitic Diseases Pathology, Armed; Forces Institute of Pathology, Washington, D.C. 20306-6000.
The newly recognized human pathogenic mycoplasma M. fermentans (incognitus strain) causes a fatal systemic infection in experimental monkeys, infects patients with AIDS, and apparently is associated with a fatal disease in previously healthy non-AIDS patients. An apparently immunocompetent male who lacked evidence of
Psychoanal Study Child. 1991;46:199-216. Unique Identifier : AIDSLINE MED/92159318
Isay RA; Cornell Medical College.
Some aspects of the work of the homosexual analyst with gay and heterosexual patients are discussed. The author examines the reasons most homosexual patients prefer to work with gay therapists, why it is usually beneficial for them to do so, and the related question of the appropriateness of revealing sexual orientati
de Luis A; Montalban J; Fernandez JM; Navarro C; Ocana I; Codina A; Martinez-Vazquez JM; Servicio de Medicina Interna-Patologia Infecciosa, Hospital; General Vall d'Hebron de Barcelona, Universidad Autonoma; Barcelona.
We present a case of polymyositis (PM) in a patient with no previous relevant medical history, who had received blood transfusion four years ago during surgery. It could be demonstrated that the patient was HIV infected inspite the fact that he did not belong to any other high risk groups. PM was the clinical presenta
The aim of the work is to develop optimal conditions for identification and purification of monoclonal antibodies specific to protein p24 of bovine leukemia virus (p24-BLV). Two schemes of isolation and purification of monoclonal antibodies are compared. Purified monoclonal antibodies contain two subunits with molecul
Angoff NR; Department of Internal Medicine, Yale University School of; Medicine, New Haven, Connecticut.
This paper responds to the question: Do physicians have an ethical obligation to care for patients with acquired immunodeficiency syndrome (AIDS)? First, the social and political milieu in which this question arises is sampled. Here physicians as well as other members of the community are found declaring an unwillingn
Ann Soc Belg Med Trop. 1991 Dec;71(4):287-94. Unique Identifier : AIDSLINE MED/92161861
Laleman G; Kambale M; Van Kerckhoven I; Kapila N; Konde M; Selemani U; Piot P; van der Groen G; Centre Regional de la Lutte contre le SIDA, Lubumbashi, Zaire.
The conventional algorithm for HIV testing based on the confirmation of all positive anti-HIV screening reactions by Western blot (WB) is too expensive for developing countries. We investigated the validity of confirming positive screening assay reactions by a second screening test, limiting the use of the supplementa
Craig JC; Duncan IB; Hockley D; Grief C; Roberts NA; Mills JS; Roche Products Ltd., Welwyn Garden City, Herts, U.K.
Ro 31-8959 inhibits the spread of HIV infection and the production of cytopathic effects in cultures of acutely infected cells. IC50 values for these effects are in the range 0.5-6.0 nM and IC90 values are in the range 6.0-30.0 nM. This inhibitor is effective even when added to cultures at a late stage of infection, a
In Hessen, obligatory health examination of refugees includes the following: Clinical examination, faecal bacteriological examination for salmonella and shigella, chest x-ray of persons aged 3 years and older, lues- and hepatitis B serology in case of persons of 16 years of age and older. The results obtained with 345
In Munich, an epicentre of rising AIDS incidence, there has been a definite increase in the number of AIDS patients under medical attendance from 1986 to 1987. Over a two-year period from 1988 to 1990, there were at least 80 more AIDS-related deaths in the city of Munich alone than the number officially certified by t
Jarchow R; AIDS-Beratungsstelle am Gesundheitsamt Koln.
Nobody questions that public health offices have the legal obligation to engage in AIDS prevention. Public health authorities will always ensure that there is cooperation with other local organisations (AIDS-Hilfen, drug-counselling agencies, gay organisations, self-help groups, welfare associations), but coordination
LMS of heroin addicts with AIDS is to be seen first of all as a part of AIDS prevention, secondly as an individual help for these very ill patients. The legal basis for North-Rhine Westphalia is described. In the district of Recklinghausen the Public Health Office developed a procedure for the LMS according to existin
Deloch M; Anonyme AIDS-Beratungsstelle der Gesundheitsbehorde der; Landeshauptstadt Munchen.
As early as 1984 we have already been offering an advisory service at the Gesundheitshaus (Health Building) in Munich. Since August 1987 we have our own department, strictly separated from the other departments of the Health Ministry both with regard to location and personnel, and staffed with 7 doctors, 3 social work
Ammon A; Bayer. Staatsministerium des Innern, Munchen.
The following results are parts of two questionnaires carried out at Fachoberschule Freising in December 1988 and April 1990. The answers from the questions about the HIV-Test showed a considerable lack of detailed knowledge. Only 47% (in December 1988) respectively 20% (in April 1990) could correctly assess the meani
Hofmeister-Wagner WD; Wiesner von Jagwitz E; Streidl C; Peters M; Stadtgesundheitsamt Frankfurt am Main.
The effect of Levomethadon on the amount of the lymphocyte subpopulation (CD4/CD8) was studied during 18 months in 18 HIV-infected heroin addicted patients. While the overall clinical aspect of all patients improved remarkably there was no significant change in the amount of the lymphocyte subpopulation.
An emancipatory strategy of AIDS prevention is shown to be practical. Risks and limits of such an approach are analysed. Special attention is given to the danger that AIDS-related problems may in the long run be handled only as a technical administration process returning to the principle of blaming the victim. The Fe
The structure and tasks of an AIDS working team are presented. This team consists of specially trained AIDS care staff from various institutions in Northern Rhineland-Palatinate. The advantage consists of the possibility of cooperative teamwork in the spheres of prevention and advice.
Tymister G; Psychiatrische Klinik der Heinrich-Heine-Universitat, Dusseldorf.
It is essential for HIV-positive outpatients to come to terms with their disease by learning to accept their new situation and to adjust their lives to it. Since 1988 the HIV-outpatient welfare centre at the Dusseldorf Public Health Department has been taking care of HIV-positive outpatients, offering a combination of
The number of persons suffering from AIDS is continually increasing. Although politicians, in particular, had been hopeful that spread of information would solve the AIDS problem, we are now facing an unexpectedly large number of AIDS patients requiring help, a number that is growing all the time. Most of the problem
Urbanczik R; Med.-diagnost. Institut der Fatol Arzneimittel GmbH Uni; Heidelberg.
Microscopy is, for various reasons, even today the most important diagnostic measure for pulmonary Tb. With other forms of Tb and with other mycobacterioses there is a considerable increase in importance of the radiometric culture techniques, particularly if these are combined with serologic (ELISA and its variants) o
Community strategies, facing the rising number of drug victims, HIV-positive und AIDS patients, together with the increasing crime rate in our cities, are under discussion at various national and international scientific conferences. Based on the National Concept against Drug Abuse, presented by the German Government
Presse Med. 1991 Dec 21-28;20(44):2239-45. Unique Identifier : AIDSLINE MED/92141101
Gabarre J; Azar N; Ben Othman T; Gharakhanian S; De Sahb R; Dohin E; Sansonetti P; Langlois P; Chigot JP; Echard M; et al; Service d'Hematologie, Hopital Pitie-Salpetriere, Paris.
In order to evaluate the long-term effects of splenectomy in patients with human immunodeficiency virus-related immune thrombocytopenic purpura (ITP), we studied retrospectively two populations of patients: 21 had undergone splenectomy and 18 had not. At the time of diagnosis the first population had on average lower
Kahn J; Northfelt D; Volberding P; Department of Medicine, University of California, San Francisco.
Clinical staging and response criteria for AIDS-associated Kaposi s sarcoma (AIDS-KS) are not well-developed, but classifying patients into limited or extensive disease categories allows a clinician to select appropriate local or systemic therapy. A prospective staging system has been proposed to uniformly evaluate pr
J Tongji Med Univ. 1991;11(3):135-40. Unique Identifier : AIDSLINE MED/92148879
Li ZJ; Luo DD; Dai JZ; Zheng LL; Wang XH; Yang YX; Department of Infectious Diseases, Xiehe Hospital, Tongji Medical; University, Wuhan.
The function of spontaneous T suppressor cell (STs) of peripheral blood was examined in 56 patients with schistosomiasis japonica at various stages. The subsets of T cell were simultaneously phenotyped in 46 cases. The percentages of CD3+ (pan T cell), CD4+ (helper/inducer T cell) and CD8+ (suppressor/cytotoxic T cell
Le SY; Shapiro BA; Chen JH; Nussinov R; Maizel JV; Institute of Biological Sciences, National Research Council of; Canada, Ottawa.
RNA pseudoknot structural motifs could have implications for a wide range of biological processes of RNAs. In this study, the potential RNA pseudoknots just downstream from the known and suspected retroviral frame-shift sites were predicted in the Rous sarcoma virus, primate immunodeficiency viruses (HIV-1, HIV-2, and
Ruscetti FW; Palladino MA; Laboratory of Molecular Immunoregulation, NCI-Frederick Cancer; Research and Development Center, MD 21702-1201.
It is now apparent that the transforming growth factor beta (TGF-beta) family of proteins has potent immunoregulatory properties ranging from effects on the growth and differentiation of primitive stem cells to the differentiated functions of immune effector cells. Although most reports have described the immunosuppre
The discussions on the pros and cons of obstetric screening for connatal infections have been going on for years. We, therefore, conducted a prevalence study of the most common connatal infections. HIV infection, rubella and syphilis were not subjects of this study. We analysed the relevance of these infections in 512
Fenner TE; Garweg J; Hufert FT; Boehnke M; Schmitz H; Department of Virology, Bernhard Nocht Institute for Tropical; Medicine, Hamburg, Germany.
In 13 of 16 AIDS patients with retinitis, a herpesviruslike infection was diagnosed by clinical investigation. In 12 of the 13 patients, human cytomegalovirus (HCMV) DNA was detected in 5 microliters of aqueous humor by using the polymerase chain reaction (PCR). In the aqueous humo
Oishi I; Kimura T; Murakami T; Haruki K; Yamazaki K; Seto Y; Minekawa Y; Funamoto H; Laboratory of Virology, Osaka Prefectural Institute of Public; Health, Japan.
Chronic rotavirus infection of an infant with severe combined immunodeficiency (SCID) was studied by virological examinations in association with long-term observation of his symptoms and immune status. During eleven months of hospitalization, the patient was suffering from incurable severe diarrhea with persisting ex
Leigh TR; Wiggins J; Gazzard B; Collins JV; Department of Respiratory Medicine, Brompton Hospital, London,; U.K.
Bronchial narrowing is the major side effect of inhaled nebulised pentamidine isethionate, used for the prophylaxis and treatment of Pneumocystis carinii pneumonia. Several agents and delivery systems were assessed for prophylaxis of bronchial narrowing in HIV-positive males receiving regular nebulised pentamidine ise
Denning DW; Armstrong RW; Fishman M; Stevens DA; Department of Medicine, Santa Clara Valley Medical Center, San; Jose, California 95128.
We report a case of presumed cryptococcal endophthalmitis that occurred in a patient with severe disseminated cryptococcosis and AIDS. Multiple small, spherical lesions appeared bilaterally on the surface of the retina 2 weeks after cryptococcal meningitis was diagnosed; the lesions were associated with multiple blind
De Castro LM; Kern ER; De Clercq E; Ghaffar A; Mayer EP; Vogt PE; Gangemi JD; University of South Carolina School of Medicine, Columbia 29208.
Murine acquired immunodeficiency syndrome (MAIDS) was induced in C57BL/6 mice following infection with the LP-BM5 retrovirus complex. Infected mice developed splenomegaly, lymphadenopathy and loss of B- and T-cell functions 100 days after virus inoculation. Mice with AIDS were highly susceptible to opportunistic murin
Hoover EA; Ebner JP; Zeidner NS; Mullins JI; Department of Pathology, College of Veterinary Medicine and; Biomedical Sciences, Colorado State University, Fort Collins; 80523.
Cats infected with molecularly cloned FeLV-FAIDS develop an immunodeficiency syndrome characterized by persistent antigenemia, decline in circulating CD4+ T lymphocytes, and impaired T-cell-dependent immune responses and opportunistic infection. We evaluated the capacity of PMEA to inhibit the replication of FeLV-FAID
Eiseman JL; Yetter RA; Fredrickson TN; Shapiro SG; MacAuley C; Bilello JA; University of Maryland Cancer Center, University of Maryland; School of Medicine, Baltimore 21201.
LP-BM5 MuLV infection of C57BL/6 mice induces a well characterized, lymphoproliferative, immunodeficiency disease (MAIDS), which is useful for evaluation of potential antiviral agents, because of the reproducibility of virological and clinical endpoints. This MAIDS retrovirus model was used to evaluate 3 azido-2,3 did
Harb GE; Bacchetti P; Jacobson MA; Department of Medicine, University of California, San Francisco.
We reviewed the hospital charts of 168 patients with AIDS and cytomegalovirus ( CMV ) disease diagnosed at San Francisco General Hospital between July 1985 and October 1989. One hundred and thirty-three patients had CMV retinit
The papers in this volume cover a wide range of important topics. Yet many other equally important topics are not addressed. These include: (1) emerging trends in the epidemiology of HIV and drug use, such as the evidence that crack use may lead many of its practitioners to engage in high risk sex; (2) ways to deliver
Williams JB; Rabkin JG; Department of Psychiatry, Columbia University, New York, New; York.
The concurrent validity of the Quality-of-Life Index (QLI) is examined by comparing it with other standard measures of psychopathology and psychosocial and physical functioning in a sample of HIV-positive (HIV+) and HIV-negative (HIV-) men. Fifty gay men (29 HIV+ and 21 HIV-) were assessed on the QLI and a number of o
Platt EJ; Goodman LJ; Kain SR; Zettl KS; Firestone GL; Department of Molecular and Cell Biology, University of; California, Berkeley 94720.
We have documented previously that glucocorticoid hormones modulate the posttranslational localization of cell surface mouse mammary tumor virus (MMTV) glycoproteins in the viral-infected M1.54 rat HTC hepatoma cell line. To determine whether glucocorticoids affect the trafficking of individually synthesized MMTV glyc
The structure of the gamma and delta chains of the human T lymphocyte receptor has been studied extensively over the past three years. A directory of gamma/delta lymphocytes in different normal or pathological situations has been developed from the analysis of the different sub-populations of circulating (cytofluorome
Riddell SR; Reusser P; Greenberg PD; Fred Hutchinson Cancer Research Center, Seattle, Washington; 98104.
The occurrence of life-threatening infections, including cytomegalovirus ( CMV ) infection, in recipients of allogeneic bone marrow transplants is related to the severe and prolonged immunodeficiency that is present after trans
Duzgunes N; Larsen CE; Konopka K; Alford DR; Young LJ; McGraw TP; Davis BR; Nir S; Jennings M; Cancer Research Institute, University of California, San; Francisco 94143.
Szakacs JE; Kasnic G Jr; Walling AK; Pathology Service, H. Lee Moffitt Cancer Center, Tampa, FL 33682.
Cytoplasmic inclusions of great complexity are encountered in an undifferentiated sarcoma of a 67-year-old woman. The tumor arising in adipose tissue between muscles of the parspinous musculature contains inclusions in most tumor cells represented by four different morphologic types. Two are intracisternal, designated
Pastor SA; Shuster AR; Miller MM; Lam KW; Department of Ophthalmology, University of Texas Health Science; Center, San Antonio 78284.
Utilizing transmission electron microscopy, the authors describe results obtained from cellulose acetate impressions of the bulbar conjunctiva in acquired immunodeficiency syndrome patients with cytomegalovirus ( CMV ) retiniti
Essers S; Schwinn A; ter Meulen J; von Lips H; Dietz K; Mhalu FS; Shao J; ter Meulen V; Institut fur Virologie und Immunbiologie, Universitat; Wurzburg, FRG.
A seroepidemiological evaluation of the humoral immune response against human herpes viruses was carried out in patients with and without HIV infection in Tanzania to study the role of these viruses as a cofactor in AIDS. Serum specimens were obtained from 321 outpatients and 100
Ayisi NK; Gupta SV; Qualtiere LF; Noguchi Memorial Institute for Medical Research, University of; Ghana, Legon.
A modified tetrazolium-based colorimetric assay was used to determine the anti-HIV activities of ddAzThd, ddCyd, ddIno, and PFA. In this assay, poly-1-lysine-coated plates were used to attach the MT-2 cells to the bottom of the plates. A fixed amount of virus (50 TCID50) was used in each well. A modified version of th
Fox JC; Ait-Khaled M; Webster A; Emery VC; Division of Communicable Diseases, Royal Free Hospital School of; Medicine, London, U.K.
The sensitivity of the polymerase chain reaction (PCR) can mean that even very low levels of contamination with the target DNA will result in a positive signal. At present this aspect is a major limitation in the use of PCR as a routine diagnostic method. By exposing PCR reagents to UV light, contaminating DNA can be
Pallesen G; Hamilton-Dutoit SJ; Rowe M; Lisse I; Ralfkiaer E; Sandvej K; Young LS; Laboratory of Immunohistology, University Institute of Pathology,; Aarhus Kommunehospital, Denmark.
Epstein-Barr virus (EBV) infection in lymphoproliferative lesions has been assumed to be strictly latent. In order to investigate the possible occurrence of EBV replication in AIDS-related lymphoma (ARL) cells, we studied 13 cases by immunohistology using monoclonal antibodies to the EBV-encoded switch-protein BZLF1,
Med Microbiol Immunol (Berl). 1991;180(4):193-204. Unique Identifier : AIDSLINE MED/92149491
Hamann A; Doerr HW; Department of Medical Virology, University Clinics of Frankfurt,; Federal Republic of Germany.
We investigated the IgG subclass reactivity pattern to early antigens (EA) of human cytomegalovirus (HCMV) in 217 EA-antibody-positive sera from immunocompetent, healthy persons, renal transplant recipients and AIDS patients by immunoblotting. All IgG subclasses are involved in the
Byard RW; Mikhael NZ; Orlando G; Cyr RM; Prefontaine M; Department of Histopathology, Adelaide Children's Hospital.
A healthy 20 yr old woman presented for evaluation following a cervical smear which showed viral effects typical of human papilloma virus. Colposcopy showed changes of cervicitis with the main finding on histologic examination of biopsy material being an acute and chronic cervicitis associated with typical features of
Vet Rec. 1991 Dec 7;129(23):502-4. Unique Identifier : AIDSLINE MED/92151394
Mtambo MM; Nash AS; Blewett DA; Smith HV; Wright S; Department of Veterinary Medicine, Glasgow University Veterinary; School.
A clinical and post mortem survey of domestic and feral cats in the Glasgow area revealed that 19 of 235 (8.1 per cent) were infected with Cryptosporidium species. More kittens than adults were infected (P less than 0.01), and of 51 of the cats which had diarrhoea, four also had cryptosporidium infection. Of seven dom
Shintaku M; Inoue N; Sasaki M; Izuno Y; Ueda Y; Ikehara S; Department of Pathology, Osaka Red Cross Hospital, Japan.
A case of cytomegalovirus ( CMV ) vasculitis in the intestine of a patient with acquired immune deficiency syndrome (AIDS) is reported. The distal jejunum and ileum had multiple well-demarcated mucosal ulcers and microscopic ex
Heller HM; Fuhrer J; Infectious Disease Unit, Massachusetts General Hospital, Boston; 02114.
Sporotrichosis is the disease caused by the dimorphic fungus Sporothrix schenkii. Disseminated sporotrichosis is an uncommon infection which usually occurs in alcoholics or patients receiving immunosuppressive medication. We report a case of a patient with AIDS who had disseminated sporotrichosis which was progressive
Home Healthc Nurse. 1991 Nov-Dec;9(6):33-7. Unique Identifier : AIDSLINE MED/92155935
Gary GA
Increasingly, home healthcare nurses will be called on to assist HIV-infected clients to manage as independently as possible within their homes. Familiarity with the neurologic manifestations of HIV is vital to assessing, planning, and implementing effective nursing care.
J Am Vet Med Assoc. 1991 Sep 1;199(5):584-8. Unique Identifier : AIDSLINE MED/92156040
Sprecher DJ; Pelzer KD; Lessard P; Department of Large Animal Clinical Sciences, Virginia-Maryland; Regional College of Veterinary Medicine, Virginia Polytechnic; Institute and State University, Blacksburg 24061-0442.
A bovine leukemia virus (BLV) control program was instituted at a high-prevalence, purebred Holstein dairy. The specific control program required single use of needles and obstetrical sleeves, disinfection of tattoo equipment before use, dehorning by use of electrical burning devices, replacement of whole milk feeding
A growing number of cases of HIV infection and AIDS in the U.S. have been reported among intravenous drug users and their sexual partners. This increase in cases has begun to have a significant impact on substance abuse treatment programs; in addition to the complexities of HIV education and counseling, the staff of s
The basal level of secretion of hypophyseal (ACTH, STH) and peripheral glucocorticoid (cortisol, corticosterone) hormones as related to the immune status (lymphocyte subpopulations, serum immunoglobulins, circulating immune complexes, macrophagal component) and specific marker profiles of viruses B and delta was measu
Fox RI; Luppi M; Kang HI; Pisa P; Department of Rheumatology and Immunology, Scripps Clinic and; Research Foundation, La Jolla, CA 92037.
Sjogren s syndrome (SS) is a chronic autoimmune disease characterized by severe dryness of the eyes and mouth, resulting from lymphocytic infiltration of the lacrimal and salivary glands. SS may exist as a primary condition (primary SS, 1.SS) or as a secondary condition (2.SS) in association with rheumatoid arthritis,
Okada K; Hosokawa Y; Aida Y; Ohshima K; Department of Veterinary Pathology, Faculty of Agriculture, Iwate; University, Japan.
Bovine leukemia virus (BLV) RNA was demonstrated in peripheral blood lymphocytes treated with concanavalin A or phytohemagglutinin from a BLV-infected ox, and in lymphosarcoma cells cultured without mitogen from an enzootic bovine leukosis cow by in situ hybridization using biotinylated DNA probes.
Ann Neurol. 1991 Oct;30(4):597-604. Unique Identifier : AIDSLINE MED/92161748
Gillespie SM; Chang Y; Lemp G; Arthur R; Buchbinder S; Steimle A; Baumgartner J; Rando T; Neal D; Rutherford G; et al; Division of Viral and Ricketssial Diseases, Centers for Disease; Control, Atlanta, GA.
Progressive multifocal leukoencephalopathy (PML), a rare neurological disease, has been sporadically reported in persons infected with human immunodeficiency virus (HIV), the causative agent of acquired immune deficiency syndrome (AIDS). From January 1981 through February 1989, in San Francisco, we identified 94 HIV-i
Chimirri A; Grasso S; Monforte AM; Monforte P; Zappala M; Dipartimento Farmaco-Chimco, Universita di Messina, Italy.
A series of 1-aryl-1H,3H-thiazolo[3,4-a]benzimidazoles were synthesized by one-pot reaction from o-phenylenediamine, 2-mercaptoacetic acid and a variety of aromatic aldehydes. All compounds obtained were evaluated for antiviral activity against human immunodeficiency virus (HIV). Compounds 4g, 4i, 4j, 4l and 4q exhibi
Dax EM; Adler WH; Nagel JE; Lange WR; Jaffe JH; Addiction Research Center, National Institute on Drug Abuse, NIH,; Baltimore, MD 21224.
Effects on the human immune system of volatile nitrite inhalation were studied in 18 male volunteers. While nitrite inhalation decreased the absolute number of CD3+ T lymphocytes during the period of inhalation, cell numbers returned to pre-treatment levels within one week after cessation of the drug. Nitrite inhalati
Garber GE; Cameron DW; Hawley-Foss N; Greenway D; Shannon ME; Department of Medicine, Ottawa General Hospital, Canada.
The use of ozone therapy is reported to be effective in a variety of viral illnesses, including HIV disease. We performed a phase I study of ozone blood treatments in 10 patients in whom no significant toxicity was observed. Three patients with moderate immunodeficiency showed improvement in surrogate markers of HIV-a
Zangerle R; Fuchs D; Reibnegger G; Fritsch P; Wachter H; Department of Dermatology and Venerology, University of; Innsbruck, Austria.
We evaluated the number and percentage of CD4+ T cells, the ratio of CD4+ T cells to CD8+ T cells, the serum levels of beta 2- microglobulin and urinary levels of neopterin for their ability to predict disease progression (defined as clinical AIDS and/or oral candidiasis in combination with a CD4+ T cell count less th
Schmid DS; Mawle AC; Division of Viral and Rickettsial Diseases, Centers for Disease; Control, Atlanta, Georgia 30333.
Much of the evidence that implicates cytotoxic T lymphocytes (CTLs) in the control of infections due to herpes simplex virus (HSV) is circumstantial. However, the ease of induction of HSV-specific CTLs in vitro, the evidence from clinical observations in humans, and the protection afforded by adoptively transferred CT
Stein BS; Engleman EG; Stanford Blood Center, Stanford University School of Medicine,; Palo Alto, CA.
Although the mechanism responsible for HIV-1 entry into susceptible CD4+ T cells is incompletely understood, a number of key components are now known. For example, the tropism of HIV-1 for cells expressing the CD4 membrane glycoprotein reflects the use of this protein as a specific viral receptor to which the HIV-1 gp
J Health Care Poor Underserved. 1991 Summer;2(1):41-50; discussion 51. Unique Identifier : AIDSLINE MED/92144818
Bateman D; College of Physicians and Surgeons, Columbia University, New; York, NY.
To the longstanding cycle of poverty, disease, and despair that has afflicted several generations of Harlem residents have now been added epidemics of crack abuse, AIDS, syphilis, and pervasive violence. The community s children have been especially vulnerable to these calamities. Harlem s traditional institutions of
To clarify the prevalence of concurrent infection with hepatitis C virus (HCV), hepatitis B virus (HBV) and human T cell leukaemia virus (HTLV), we measured HCV antibody in the population of a district endemic for HBV and HTLV infection. Blood samples were collected in June 1990 from 579 inhabitants of four islands of
Kundu SK; Merigan TC; Center for AIDS Research, Stanford University School of Medicine,; California 94305.
Profiles of CD8+CD11+ T suppressor cells, human immunodeficiency virus (HIV)-env-specific cytotoxic T-lymphocyte (CTL) activities, and natural killer (NK) cell activity were studied in 12 asymptomatic untreated HIV-infected patients. These patients were followed for 4-7 months. NK activity, HIV-env-specific CTL activi
Garcia Rodriguez MC; Omenaca F; Ferreira A; Madero R; Zapico R; Muro M; De Jose I; Fontan G; Immunology Unit, Hospital La Paz, Madrid, Spain.
From November 1985 to January 1990 we examined 156 children born to 154 HIV-1 seropositive mothers every 3 months. Eighty-seven infants were over 18 months by January 1990. Six of them met the CDC criteria of HIV-1 infection or died from AIDS; a transmission rate of 7%. Six of the children aged less than 18 months als
Lifson AR; Hessol NA; Buchbinder SP; Holmberg SD; Department of Epidemiology and Biostatistics, School of Medicine,; University of California, San Francisco 94143-0560.
Early intervention guidelines in HIV infection require knowledge of CD4+ lymphocyte count; however, CD4+ determinations require special laboratory procedures and may not be readily available in all situations. Using data from 207 HIV-seropositive homosexual men without AIDS, we evaluated the association of difference
Phillips AN; Lee CA; Elford J; Webster A; Janossy G; Griffiths PD; Kernoff PB; Department of Public Health, Royal Free Hospital, London, UK.
A cohort of 111 HIV-infected haemophiliacs has been followed for up to 11 years, during which time 33 patients have been diagnosed with AIDS. Twenty-seven of the cohort developed detectable p24 antigenaemia while remaining free of AIDS. These patients experienced an increased risk of progression to AIDS compared with
Galli M; Ridolfo AL; Balotta C; Riva A; Cocchi F; Musicco M; Albarello V; Moroni M; Institute of Infectious Diseases, University of Milan, Italy.
Laboratory parameters which are modified following administration of zidovudine are becoming increasingly useful in monitoring the efficacy of treatment of early stages of HIV-1 infection. The serum levels of soluble interleukin (sILR)-2 receptor, which have been reported to increase early in HIV-1 infection, were fou
Med Hypotheses. 1991 Nov;36(3):273-6. Unique Identifier : AIDSLINE MED/92157910
Ablin RJ; Robert Benjamin Ablin Foundation for Cancer Research, Port; Jefferson, NY 11777.
30-50% of infants born to HIV-1 seropositive mothers are infected. Although a vertical transmission of the virus to the foetus via trophoblastic cells and mechanisms of its access thereof have been made, one of several questions which remains is: how do HIV-1 infected cells of monocyte/macrophage (MM) lineage, i.e. Ho
Chandra P; Gerber T; Chandra A; Sarin PS; Pavlikov SP; Sidorovich I; Khaitov R; Ivanov V; Koziach A; Laboratory of Molecular Biology, University Medical School,; Frankfurt am Main, FRG.
With the aid of monoclonal antibodies to the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1), low-molecular-mass subunits (p29, p32, and p40) were identified in HIV-1 RT purified from HIV (HTLV-IIIB) virions by isoelectric focusing. Epitope mapping with synthetic polypeptides from various reg
Del Gobbo V; Foli A; Balzarini J; De Clercq E; Balestra E; Villani N; Marini S; Perno CF; Calio R; Department of Experimental Medicine, II University of Rome,; Italy.
In order to evaluate the influence of antiviral nucleoside analogues upon the natural immune system, we investigated the immunomodulatory activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA), a nucleotide analogue with potent anti-HIV and anti-herpes activity, in a murine system. C57BL/6 mice were inoculated intrape
Teeuwsen VJ; Lange JM; Keet R; Schattenkerk JK; Debouck C; van den Akker R; Goudsmit J; Osterhaus AD; Laboratory of Immunobiology, University of Amsterdam, The; Netherlands.
The in vitro synthesis of HIV-1, p24-, reverse transcriptase (RT)- and gp120-specific immunoglobulin (Ig) G by unstimulated peripheral blood mononuclear cells (PBMC) from 38 asymptomatic and 10 symptomatic HIV-1-seropositive individuals was analysed. In the majority of these individuals, spontaneous production of HIV-
Monoclonal antibodies (termed as APP.1 and related to subclass IgG1) against seal alkaline phosphatase, have been obtained. APP.1 did not influence the enzymatic activity of alkaline phosphatase. The dissociation constant for the APP.1 interaction with
Halliwell B; Pulmonary Medicine, UC Davis Medical Center, Sacramento.
A free radical is any species capable of independent existence that contains one or more unpaired electrons. Free radical reactions have been implicated in the pathology of more than 50 human diseases. Radicals and other reactive oxygen species are formed constantly in the human body, both by deliberate synthesis (e.g
Smith D; Gazzard B; Westminster Hospital, London, England.
Pneumocystis carinii pneumonia (PCP) is seen in people with a defect in cell-mediated immunity. Today the most common cause for this is the Acquired Immunodeficiency Syndrome (AIDS). There have been some remarkable advances recently in the development of new drug regimens to combat this otherwise fatal infection. Alth
Finter NB; Chapman S; Dowd P; Johnston JM; Manna V; Sarantis N; Sheron N; Scott G; Phua S; Tatum PB; Wellcome Research Laboratories, Beckenham, Kent, England.
The interferons (IFN) act too slowly to arrest acute viral infections, but interferon-alpha (IFN alpha) preparations have proved useful in some chronic infections and will clearly be used increasingly in these in the future. In the preparations derived from human leucocytes or cultured B lymphoblastoid cells, which ar
Seya T; Department of Immunology, Center for Adult Diseases, Osaka.
C3-deposition is a key step for activation of the complement system, which involves C9-mediated immunocytolysis, immunoadherence, C3 receptor-mediated phagocytosis, NK potentiation, anaphylatoxin release, and amplification of C3 activation. Foreign material is eliminated even in the preimmune stage by these complement
Adv Exp Med Biol. 1991;300:45-55. Unique Identifier : AIDSLINE MED/92142858
Gartner S; Ohashi K; Popovic M; Primate Research Institute, New Mexico State University, Holloman; AFB 88330.
The isolate HTLV-IIIB is used by a large number of investigators for a variety of studies. The data shown here emphasize the uniqueness of this isolate with respect to certain biological behaviors, in particular, the ability to infect cells other than T lymphocytes and mononuclear phagocytes, and the ability to infect
Gasparini V; Chiaramonte M; Moschen ME; Fabris P; Altinier G; Majori S; Campello C; Trivello R; Chair of Hygiene, University of Udine, Italy.
Seroprevalence of Hepatitis C virus (HCV), Hepatitis B virus (HBV) and HIV antibodies was studied in a group of 259 apparently healthy homosexual men of the Veneto Region ( Italy ). Subjects were recruited between 1987 and 1989 from homosexual men s clubs. Seropositivity was evaluated
Mace AL; Wallace KL; Whan MQ; Stelmachowicz PG; Boys Town National Research Hospital, Omaha, Nebraska.
This study examined factors which may affect early identification of hearing loss. The medical records of 123 children with educationally significant hearing impairment were examined. Information about each child s degree and type of hearing loss, etiology, referral source, birth and medical history, additional handic
Escaich S; Ritter J; Rougier P; Lepot D; Lamelin JP; Sepetjan M; Trepo C; INSERM Unit 271, Lyon, France.
Two hundred and twenty-eight blood samples from 154 HIV-seropositive subjects were investigated for the presence of HIV in peripheral blood mononuclear cells (PBMC) and plasma (without prior ultracentrifugation or filtration), using normal PBMC as the target for replication. HIV was recovered from PBMC and plasma in 8
Med Lab Sci. 1991 Jul;48(3):171-4. Unique Identifier : AIDSLINE MED/92157822
Barbara JA; Contreras M; North London Blood Transfusion Centre, England, UK.
The implications of testing all blood donations in the UK for antibody to hepatitis C virus (HCV) are considered. Although the risks of serious liver disease arising from transfusion-transmitted HCV are relatively low in the UK, the cost of such screening will be high in terms of financial outlay and lost donations. I
Can Assoc Radiol J. 1992 Feb;43(1):55-9. Unique Identifier : AIDSLINE MED/92127478
Bourgouin PM; Melancon D; Carpenter S; Tampieri D; Ethier R; Department of Radiology, Montreal Neurological Institute, Que.
Toxoplasmosis is a frequent cause of infection of the central nervous system (CNS) in patients with acquired immunodeficiency syndrome. Computed tomography (CT) usually shows solitary or multiple parenchymal lesions, which are most often located in the cortex, the juxtacortical white matter and the basal ganglia. The
Sahraoui Y; Ammar A; Lunardi-Iskandar Y; Tsapis A; Spanakis E; N'Go N; Allouche M; Bellile VG; Jasmin C; Georgoulias V; Oncogenese Appliquee, INSERM U268, Hopital Paul Brousse,; Villejuif, France.
The constitutively expressed IL-2R beta (p70) chain participates in the formation of high-affinity (h.a.) IL-2R and transduces IL-2-mediated signals to normal cells. Its expression on HIV-infected patients PBMC was evaluated and was found to be decreased in both nonstimulated CD4+ and CD8+ cells. Mitogenic cell stimu
Manca F; Newell A; Valle M; Habeshaw J; Dalgleish AG; Department of Immunology, San Martino Hospital, University of; Genoa, Italy.
When antigen-specific T cells are pulsed by antigen-presenting cells (APC) in the presence of HIV they are functionally deleted following subsequent exposure to syngeneic APC in the absence of HIV. Recombinant soluble HIV envelope (gp120) is able to induce a similar effect which, unlike that induced by HIV, is reversi
Fabio G; Scorza R; Lazzarin A; Marchini M; Zarantonello M; D'Arminio A; Marchisio P; Plebani A; Luzzati R; Costigliola P; Institute of Internal Medicine, Infectious Diseases and; Immunopathology, University of Milan, Italy.
We studied HLA antigen distribution of 50 heterosexual partners of HIV+ drug abusers with more than 1 year of sexual exposure to HIV, 36 children born to seropositive mothers and 61 haemophiliac patients exposed to presumably infectious clotting factor concentrates. B52 and B44 antigens were associated with HIV resist
Klaassen RJ; Goldschmeding R; Dolman KM; Vlekke AB; Weigel HM; Eeftinck Schattenkerk JK; Mulder JW; Westedt ML; von dem Borne AE; Central Laboratory of the Netherlands Red Cross Blood Transfusion; Service, Amsterdam.
Antibodies against cytoplasmic antigens of neutrophils, producing perinuclear (p-ANCA) as well as cytoplasmic staining with central accentuation (c-ANCA), have been described in non-HIV-infected patients with specific pathology such as glomerulonephritis and vasculitis. Here, we report on a patient with a vasculitis-l
Zubler RH; Perrin LH; Doucet A; Zhang X; Huang YP; Miescher PA; Department of Medicine, Hopital Cantonal Universitaire, Geneva,; Switzerland.
Peripheral blood mononuclear cells (PBMC) from HIV-infected seropositive (HIV+) but not from normal, seronegative (HIV-) individuals are known to produce anti-HIV antibodies in vitro, in the absence or presence of pokeweed mitogen (PWM). Previous studies showed that up to 20-40% of spontaneously immunoglobulin-secreti
Dadaglio G; Michel F; Langlade-Demoyen P; Sansonetti P; Chevrier D; Vuillier F; Plata F; Hoffenbach A; Laboratoire d'Immunopathologie des Retrovirus, Institut Pasteur,; Paris, France.
Zidovudine or 3 -azido-2 -3 -dideoxy-thymidine ( AZT ) is an antiviral drug widely used to treat HIV-infected patients. Because cytotoxic T lymphocytes (CTL) are thought to contribute actively to resistance against HIV-induced disease, we studied sequen
Leibovitz E; Kaul A; Rigaud M; Bebenroth D; Krasinski K; Borkowsky W; Department of Pediatrics, New York University Medical Center,; Bellevue Hospital, New York.
Chronic zoster represents an infrequent presentation of varicella zoster virus infection. It is observed with increased frequency in patients infected with human immunodeficiency virus, especially when their lymphocyte counts are depressed. We report a child infected with human immunodeficiency virus who showed a long
A 33-year-old patient with AIDS, and a history of episodes of Pneumocystis carinii pneumonia and cerebral toxoplasmosis, developed a subcutaneous paravertebral infiltrate, which at first resembled a haematoma. Over a period of several weeks, the lesion spread to cover almost the entire back. Initially, numerous invest
Int J Biochem. 1992 Feb;24(2):235-42. Unique Identifier : AIDSLINE GENBANK/X64242
Pichova I; Strop P; Sedlacek J; Kapralek F; Benes V; Travnicek M; Pavlickova L; Soucek M; Kostka V; Foundling S; Institute of Organic Chemistry and Biochemistry, Czechoslovak; Academy of Science, Prague.
1. The p15gag proteinase responsible for the processing of the polyprotein precursor of the myeloblastosis associated virus was obtained by a recombinant technique in an E. coli expression system. The massive expression of the intentionally truncated precursor (Pr25lac-delta gag) was accompanied by its structurally co
Sudo T; Ozawa K; Soeda EI; Nomura N; Ishii S; Tsukuba Life Science Center, Institute of Physical and Chemical; Research (RIKEN), Ibaraki, Japan.
The human gene encoding the human immunodeficiency virus type 1 enhancer binding protein HIV-EP2 has been isolated. Using Southern analysis of human-rodent somatic cell hybrid DNA with a human HIV-EP2-specific cDNA probe, the HIV-EP2 gene was assigned to chromosome 6. The gene was further localized to the region 6q23-
Johnson JE; Serology Reference Laboratory (113A), Veterans Administration; Medical Center, Lexington, Kentucky 40511.
A total of 575 serum specimens received for human immunodeficiency virus type 1 (HIV-1) antibody determination were tested prospectively by enzyme immunoassay with a whole-cell viral lysate (VL) (Genetic Systems Corp.), a synthetic peptide (SP) ( United Biomedical , Inc.), and a
Merz WG; Kodsy S; Merz CS; Department of Laboratory Medicine, Johns Hopkins Medical; Institutions, Baltimore, Maryland 21205.
We report the recovery of Histoplasma capsulatum from blood specimens cultured for Mycobacterium sp. in BACTEC 13A radiometric medium. H. capsulatum was recovered from six of eight blood specimens submitted for mycobacterial cultures from five human immunodeficiency virus-positive individuals. Initial positive metabol
Brandt CD; Rakusan TA; Sison AV; Josephs SH; Saxena ES; Herzog KD; Parrott RH; Sever JL; Children's National Medical Center, Washington, D.C. 20010.
Polymerase chain reaction (PCR) testing using up to four primer pairs and biotinylated probes was 97.9% sensitive (188 of 192 specimens positive) and 100% specific (267 of 267 specimens negative) for detecting the presence or absence of human immunodeficiency virus (HIV) DNA in peripheral blood mononuclear cells from
Md Med J. 1992 Jan;41(1):31-5. Unique Identifier : AIDSLINE MED/92130709
Karker-Jennings K; Berkey MF; Health Law Reimbursement Division, Rifkin, Evans, Silver &; Rozner, Baltimore, Maryland.
Recently, a great deal of attention has been focused on health care providers who have or may have the human immunodeficiency virus or, as it is known in its later stages, acquired immunodeficiency syndrome. This article explores some of the duties physicians have, or soon may have, to their patients and employers in
Med Pediatr Oncol. 1992;20(2):105-13. Unique Identifier : AIDSLINE MED/92130884
Patte C; Kalifa C; Flamant F; Hartmann O; Brugieres L; Valteau-Couanet D; Bayle C; Caillaud JM; Lemerle J; Department of Pediatrics, Institut Gustave Roussy, Villejuif,; France.
From May 1981 to June 1989, 84 children with non-B-cell lymphoma (82 lymphoblastic, 1 T-cell immunoblastic, 1 unclassified diffuse lymphoma) were treated in the pediatric department of the Institut Gustave Roussy according to a protocol called LMT81, which was derived from the LSA2L2 protocol of Wollner and modified b
Strategies to identify and influence persons at increased risk for infection with human immunodeficiency virus (HIV) and other sexually transmitted diseases (STDs) require outreach to provide prevention messages directly to persons at risk, assist them to obtain prevention services, and encourage them to reduce risks.
Sperling RS; Joyner M; Hassett J; Kee R; Wheatley P; Bauer C; Department of Obstetrics/Gynecology, City Hospital Center at; Elmhurst-Mount Sinai School of Medicine (CUNY), NY 10029.
Epidemic increases in active syphilis have been reported in the geographic areas hit hard by acquired immunodeficiency syndrome. Although both epidemics have been associated with illicit substance abuse, the extent to which recent increases in syphilis are linked to the human immunodeficiency virus (HIV-1) epidemic is
DiClemente RJ; Durbin M; Siegel D; Krasnovsky F; Lazarus N; Comacho T; Center for AIDS Prevention Studies, University of California, San; Francisco 94105.
Condoms reduce the risk of human immunodeficiency virus (HIV) transmission; however, their use among adolescents has been inconsistent. Little is known about factors which motivate consistent condom use, particularly among younger adolescents. In a study designed to identify such factors, 1899 inner-city junior high s
Mattern CF; Murray K; Jensen A; Farzadegan H; Pang J; Modlin JF; Department of Pediatrics, Johns Hopkins University School of; Medicine, Baltimore, MD.
Evidence of human immunodeficiency virus (HIV) replication was sought in human placentas obtained at term from pregnancies complicated by maternal HIV infection. Placentas were obtained from the pregnancies of 19 HIV-seropositive women, 4 women who were seronegative, and 4 untested women with no risk factors for HIV i
Bass JL; Mehta KA; Eppes B; Department of Pediatrics, Framingham Union Hospital, MA 01701.
A screening program based in a Massachusetts community hospital primary care clinic, which included 124 children from 12 different Latin American countries, demonstrated that nearly 35% were carriers of pathogenic parasites. The large majority (83.7%) of these children were asymptomatic at the time of the examination.
Lederman SA; Center for Population and Family Health, School of Public Health,; Columbia University, New York, NY.
This paper discusses the literature dealing with breast-feeding in women with human immunodeficiency virus (HIV) infection. This review is used to develop a background for a quantitative assessment of factors determining whether breast-feeding or bottle-feeding will result in a lower overall mortality in areas of diff
Papiernik M; Brossard Y; Mulliez N; Roume J; Brechot C; Barin F; Goudeau A; Bach JF; Griscelli C; Henrion R; et al; Institut National de la Sante et de la Recherche Medicale; (INSERM) U 345, Hopital Necker, Paris, France.
Pathological abnormalities of the thymus were found in 3 of 37 fetuses aborted from human immunodeficiency virus (HIV)-infected mothers. These lesions were located predominantly in the thymic cortex, which contains mostly immature lymphocytes. Areas of focal lymphocyte depletion were infiltrated with CD4+ macrophages
South Med J. 1992 Jan;85(1):37-9. Unique Identifier : AIDSLINE MED/92132706
Kadakia SC; Kadakia AS; Westphal KW; Department of Medicine, Letterman Army Medical Center, Presidio; of San Francisco, Calif.
Gastrointestinal Kaposi s sarcoma can occur in HIV-infected patients without previously diagnosed AIDS. Gastrointestinal symptoms in such patients should be thoroughly investigated because of the possibility of gastrointestinal Kaposi s sarcoma, despite the absence of the cutaneous form. The discovery of gastrointesti
West J Med. 1992 Jan;156(1):36-8. Unique Identifier : AIDSLINE MED/92132998
Lewis CE; Montgomery K; Department of Medicine, University of California, Los Angeles; 90024-1772.
We conducted a telephone survey of a random sample of office-based primary care physicians in Los Angeles County to determine their practice experiences with patients infected with the human immunodeficiency virus (HIV). Telephone interviews included questions related to the physicians experiences evaluating patients
Grunfeld C; Pang M; Shimizu L; Shigenaga JK; Jensen P; Feingold KR; Department of Medicine, University of California, San Francisco.
To assess the causes of short-term weight loss in patients with acquired immunodeficiency syndrome (AIDS), we measured resting energy expenditure (REE), caloric intake, and the 28-d weight trend in control subjects, human immunodeficiency virus (HIV)+ subjects, AIDS patients, and AIDS patients during secondary infecti
Am J Gastroenterol. 1992 Feb;87(2):224-9. Unique Identifier : AIDSLINE MED/92133573
Cappell MS; Gupta A; Department of Medicine, University of Medicine of New Jersey,; Robert Wood Johnson (Rutgers) Medical School, New Brunswick.
A 33-yr-old black intravenous drug abuser with the acquired immunodeficiency syndrome (AIDS) had a massive fatal upper gastrointestinal hemorrhage due to profound and diffuse esophageal ulceration from Candida, as demonstrated by postmortem examination. A 2-yr-old white male with congenitally acquired AIDS had a massi
Noronha IL; Daniel V; Schimpf K; Opelz G; Department of Transplantation Immunology, University of; Heidelberg, Germany.
We measured plasma concentrations of soluble receptors for IL-2 (sIL-2R) and tumour necrosis factor-alpha (TNF-alpha) in 149 haemophilia patients. Soluble IL-2R levels were elevated in 37% of 62 HIV-seronegative patients (mean 570 +/- 27 U/ml versus 361 +/- 17 U/ml in
McFadden RG; Carr TJ; Mackie ID; Department of Medicine, St Joseph's Health Centre, London,; Canada.
Magnetic resonance imaging of the thorax was performed on ten occasions in eight HIV-positive patients with a clinical picture suggestive of Pneumocystis carinii pneumonia. The diagnosis of PCP was subsequently confirmed on six occasions. Patients without PCP had low MRI profusion scores, while four of six patients wi
Polos PG; Wolfe D; Harley RA; Strange C; Sahn SA; Medical University of South Carolina, Division of Pulmonary and; Critical Care Medicine, Charleston 29425.
Pulmonary hypertension may be primary (idiopathic) or secondary. While the etiologies for secondary pulmonary hypertension are diverse, infection with the human immunodeficiency virus (HIV) has not been included. To date there have been 16 reported cases of pulmonary hypertension in the HIV-infected population. Plexog
Pierce JR Jr; Sims SL; Holman GH; Amarillo BiCity-County Health Unit, Regional Academic Health; Center, Amarillo.
A patient with acquired immunodeficiency syndrome (AIDS) was admitted to a hospital with cough and fever and after 29 days was transferred to a hospice. He was eventually shown to have active pulmonary tuberculosis. This diagnosis was obscured clinically by simultaneous infection with Pneumocystis carinii and Mycobact
Dreyfuss D; Djedaini K; Bidault-Lapomme C; Coste F; Service de Reanimation Medicale, Hopital Louis Mourier,; Colombes, France.
We present the cases of two young heroin addicts seropositive for HIV who had life-threatening spontaneous acute anterior mediastinitis due to Staphylococcus aureus. This was the consequence of the spreading to the mediastinum of an infection of the chest wall. Complete cure was achieved with antibiotics and surgical
Serum concentrations of trypsin and elastase I were determined in 109 HIV Ab-positive patients (52 asymptomatic HIV-infected patients, 25 with lymphadenopathy syndrome, and 32 with acquired immunodeficiency syndrome) to assess the prevalence of possible pancreatic damage in these patients. Serum trypsin was abnormally
Int J Health Serv. 1992;22(1):73-88. Unique Identifier : AIDSLINE MED/92138101
Frankenberg R; Centre for Medical Social Anthropology, University of Keele,; Newcastle Upon Tyne, Staffordshire, England.
The history of epidemics reveals the imposition of controls over time and space on the sick and powerless other in the interests of the well and powerful same. In contrast, effective prevention requires the sharing of values, space, and time: coevality in the broadest sense. Adolescents are seen as merely transitional
Korniewicz DM; Kirwin M; Cresci K; Markut C; Larson E; School of Nursing, Johns Hopkins University, Baltimore, MD 21205.
This study was designed to compare use patterns and leakage of gloves from two high-risk units: a surgical intensive care unit (SICU) and an acquired immunodeficiency syndrome (AIDS) unit. During a 3-month interval, the use of gloves during clinical procedures by nursing personnel was observed and recorded. A total of
The early natural history of HIV does not differ markedly from that of other lymphotropic pathogens. However, the HIV lentivirus has a number of unique features that not only facilitate escape from the host immune response but eventually lead to dysfunction and destruction of the immune system. Actual cure will not be
Weinstein SP; DeMaria PA Jr; Rosenthal M; Department of Psychiatry and Human Behavior, Jefferson Medical; College, Thomas Jefferson University, Philadelphia.
Persons who abuse alcohol have not been specifically targeted for education on prevention of AIDS, yet failure to address the connection between alcohol and HIV transmission may carry a heavy price.
JAMA. 1992 Feb 26;267(8):1090-4. Unique Identifier : AIDSLINE MED/92139525
Rabkin CS; Hilgartner MW; Hedberg KW; Aledort LM; Hatzakis A; Eichinger S; Eyster ME; White GC 2d; Kessler CM; Lederman MM; et al; Viral Epidemiology Section, National Cancer Institute, Rockville,; MD 20852.
OBJECTIVE--To determine the types and rates of cancers occurring in excess in the presence of infection with the human immunodeficiency virus type 1 (HIV-1). DESIGN--Cohort analytic study of HIV-infected and HIV-uninfected subjects followed for up to 12 years. SETTING--Fifteen hemophilia treatment centers. PATIENTS--A
Trenkwalder P; Trenkwalder C; Feiden W; Vogl TJ; Einhaupl KM; Lydtin H; Department of Internal Medicine, Starnberg Regional Hospital,; Germany.
Cerebral hemorrhage is a rare complication of the acquired immunodeficiency syndrome. We report a case of multifocal hemorrhage in a 37-year-old homosexual man with cerebral toxoplasmosis. Histopathologic examination, performed at cerebral autopsy, confirmed the findings on CT and MRI.
N Y State Dent J. 1992 Jan;58(1):21-3. Unique Identifier : AIDSLINE MED/92140771
Sadowsky D; Kunzel C; Department of Dentistry, Albert Einstein College of Medicine, New; York.
A survey of dentists found significant differences among groups with varying amounts of continuing education with respect to knowledge about AIDS. These findings suggest focused continuing education may be beneficial.
Proc Natl Acad Sci U S A. 1992 Feb 1;89(3):1006-10. Unique Identifier : AIDSLINE MED/92141192
Joshi JB; Dave HP; Laboratory of Biochemical Genetics, National Heart, Lung, and; Blood Institute, National Institutes of Health, Bethesda, MD; 20892.
Human T-cell lymphotropic virus type I (HTLV-I), an etiologic agent for adult T-cell leukemia, is strongly associated with certain neurological diseases. The HTLV-I genome encodes a protein, Tax1, that transactivates viral gene transcription. CD4-positive T helper lymphocytes express the proenkephalin gene, and enkeph
Ugeskr Laeger. 1992 Jan 27;154(5):267-71. Unique Identifier : AIDSLINE MED/92142312
Wielandt HB; Odense Universitet, Institut for Sygdomsforebyggelse og; Helsetjenesteforskning.
In order to illustrate whether the AIDS and Safe sex campaigns have influenced young people, an investigation originally made in 1985 was repeated in October 1989; the objects being sexual knowledge, sexual experience and contraception among persons aged 16-20 years. A representative random sample consisting of 359 wo
Kassler WJ; Cates W Jr; Division of STD/HIV Prevention, Centers for Disease Control,; Atlanta, Georgia.
Each year, approximately 12 million cases of STDs occur in the United States , including an estimated 1.4 million cases of gonorrhea, 130,000 cases of syphilis, 4 million cases of chlamydia, 500,000 to 1 million cases of human papillomavirus, 200,000 to 500,000 cases of
Kwan DJ; Lowe FC; Department of Urology, St. Luke's-Roosevelt Hospital Center, New; York, New York.
AIDS is clearly the most lethal of all the STDs. The universal adherence to safe sexual practices is required in order to try to limit this epidemic. Unfortunately, the other forms of transmission of HIV, intravenous injection and via the fetal-placental circulation, have ensured that simply altering the sexual practi
Mulligan MJ; Ritter GD Jr; Chaikin MA; Yamshchikov GV; Kumar P; Hahn BH; Sweet RW; Compans RW; Department of Medicine, University of Alabama, Birmingham 35294.
Utilizing a recombinant vaccinia expression system, we investigated the biological properties and CD4 receptor interactions of the envelope glycoproteins of a noncytopathic human immunodeficiency virus type 2 strain, termed HIV-2/ST, and a highly cytopathic variant derived from it. The efficiency and host cell range o
Smith MR; Greene WC; Howard Hughes Medical Institute, Department of Medicine, Duke; University Medical Center, Durham, North Carolina 27710.
The Tax trans-activator protein of the type I human T-cell leukemia virus is expressed predominantly in the nuclei of cells. However, this viral trans-activator is distinguished from most other nuclear proteins by the absence of a short highly basic nuclear localization signal. Previous mutational analyses of the tax
Dedera DA; Gu RL; Ratner L; Department of Medicine, Washington University School of Medicine,; St. Louis, Missouri 63110.
Transmembrane envelope protein (TM) residues 100, 105, and 128 of human immunodeficiency virus type 1 (HIV-1) strain HXB2 are potential sites for asparagine-linked oligosaccharide additions which are conserved among HIV-1 isolates, and all other lentivirus TM proteins. Site-specific mutants of each of the asparagine r
Yu G; Felsted RL; Laboratory of Biological Chemistry, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892.
The effect of myristoylation on p27nef subcellular distribution and suppression of HIV-1 transcription was examined by transfecting COS-7 cells with plasmids expressing either myristoylated (pSVnef) or nonmyristolyated p27nef (pSVnefala2). Similar levels of myristoylated and nonmyristoylated p27nef were expressed with
Am J Epidemiol. 1992 Jan 1;135(1):79-84. Unique Identifier : AIDSLINE MED/92143136
Seage GR 3d; Mayer KH; Horsburgh CR Jr; Cai B; Lamb GA; Institute for Urban Health Policy, Research, and Education,; Boston Department of Health and Hospitals, MA.
Using data from a study of human immunodeficiency virus transmission among homosexual male partners from Boston, Massachusetts, the authors compared self-reported sexual histories among 155 index-partner pairs during 1985-1988. Overall, high levels of agreement were observed for all reported sexual activities. Agreeme
Antoniskis D; Easley AC; Espina BM; Davidson PT; Barnes PF; Department of Medicine, University of Southern California School; of Medicine, Los Angeles.
Because antituberculosis agents and zidovudine are commonly used in HIV-infected patients, we performed a cohort study to determine the toxicity of such combined therapy. A group of 24 consecutive human immunodeficiency virus (HIV)-infected patients with tuberculosis who received concomitant antituberculosis therapy a
Ann R Coll Surg Engl. 1992 Jan;74(1):5-8. Unique Identifier : AIDSLINE MED/92143463
Rowe-Jones JM; Pringle MB; Royal National Throat, Nose and Ear Hospital, London.
Much attention has been focused on the risks of inoculation with the human immune deficiency virus in the operating theatre. However, less emphasis has been placed on infection resulting from outpatient exposure to this pathogen. A survey of current protective measures undertaken by ENT consultants in the outpatient c
Kinchington D; Galpin S; Jaroszewski JW; Ghosh K; Subasinghe C; Cohen JS; Department of Virology, Medical College of St. Bartholomew's; Hospital, London, U.K.
Sequences from the gag, pol and rev regions of the RF strain of HIV-1 (HIV-1RF) were chosen as targets for antisense phosphorothioate oligodeoxynucleotides (S-oligos). These sequences were the p18/p24 junction in gag, the active site of HIV protease in pol; a sequence from the first exon of the rev gene and S-oligodeo
Pagano MA; Cahn PE; Garau ML; Mangone CA; Figini HA; Yorio AA; Dellepiane MC; Amores MG; Perez HM; Casiro AD; Department of Neurology, Fernandez Hospital, Buenos Aires,; Argentina.
Brain-stem auditory evoked potentials were recorded in 35 human immunodeficiency virus (HIV)-seropositive subjects from the Centers for Disease Control groups III and IV, 24 HIV-negative drug abusers, and 62 normal healthy controls. None of the patients had evidence of neurological complications. History of alcohol co
AIDS Res Hum Retroviruses. 1992 Jan;8(1):1-7. Unique Identifier : AIDSLINE MED/92144203
Hoglund S; Ofverstedt LG; Nilsson A; Lundquist P; Gelderblom H; Ozel M; Skoglund U; Department of Biochemistry, Biomedical Center, Uppsala, Sweden.
The core of late states of maturing human immunodeficiency virus type 1 (HIV-1) has been visualized in three dimensions at approximately 7 nm resolution by electron microscopic tomography. After budding, approximately 25 nm thick precursor material is observed densely assembled inside the viral envelope. Upon proteoly
AIDS Res Hum Retroviruses. 1992 Jan;8(1):27-37. Unique Identifier : AIDSLINE MED/92144206
Gattegno L; Ramdani A; Jouault T; Saffar L; Gluckman JC; Laboratoire de Biologie Cellulaire, Faculte de Medecine; Paris-Nord, Bobigny, France.
The aim of this study was to determine whether mannosyl-specific lectins, especially Concanavalin A (ConA), may bridge HIV-1 env glycoproteins to cell membranes to increase virus binding to its targets, and to what extent this lectin-carbohydrate interaction can modify HIV-1 infectivity for monocytic compared with lym
AIDS Res Hum Retroviruses. 1992 Jan;8(1):39-45. Unique Identifier : AIDSLINE MED/92144207
Harrison GS; Long CJ; Maxwell F; Glode LM; Maxwell IH; Division of Medical Oncology, University of Colorado Health; Sciences Center, Denver 80262.
Construction of a DNA plasmid that expresses a diphtheria toxin A chain (DT-A) gene under control of human immunodeficiency virus (HIV-1) proteins Tat and Rev has been described. Here the generation of HeLa cell clones containing integrated, HIV-regulated DT-A sequences is reported. Five such clones were identified by
AIDS Res Hum Retroviruses. 1992 Jan;8(1):53-9. Unique Identifier : AIDSLINE GENBANK/X61359
Steuler H; Storch-Hagenlocher B; Wildemann B; Department of Neurology, University of Heidelberg, Germany.
The nucleotide sequence of the gp41 transmembrane protein coding region of human immunodeficiency virus type 1 (HIV-1) proviral DNA obtained from blood and cerebrospinal fluid (CSF) from 6 individuals was determined by direct sequencing of polymerase chain reaction (PCR)-amplified DNA. The direct sequencing approach w
AIDS Res Hum Retroviruses. 1992 Jan;8(1):61-7. Unique Identifier : AIDSLINE MED/92144210
Calenda V; Sebahoun G; Chermann JC; INSERM U322, Unite de Recherches sur les Retrovirus et Maladies; Associees B.P. 33, Marseille, France.
Long-term bone marrow cultures (LTBMC) have been infected by two isolates of human immunodeficiency virus type 1 (HIV-1) (HIV-1 LAV and HIV-1 NDK) at multiplicities of infection ranging from 10(2) to 2.10(6) tissue culture infectious units (TCIU) per 10(6) bone marrow mononuclear cells (BMMNC). These infected cells ar
AIDS Res Hum Retroviruses. 1992 Jan;8(1):77-88. Unique Identifier : AIDSLINE MED/92144212
Almond N; Jenkins A; Slade A; Heath A; Cranage M; Kitchin P; AIDS Collaborating Centre and Informatics Laboratory, National; Institute for Biological Standards and Control, South Mimms,; Herts, England.
The virus structural genes gag and env (both gp120 and gp41 regions) of the 32H isolate of SIVmac251 were amplified using the polymerase chain reaction (PCR). The proviral template used in the PCR was DNA isolated from cells used to prepare several experimental SIV vaccines, which have been tested in simians, and a st
The N-terminal region of the human immunodeficiency virus type 1 (HIV-1) gp41 appears to be involved in virus-cell membrane fusion. To study the influence of fusion domain structure on gp41 interaction with artificial lipid membranes, two families of peptides were synthesized. The peptides of the first family starting
Br Dent J. 1992 Jan 11;172(1):21-3. Unique Identifier : AIDSLINE MED/92144288
Southam JC; Felix DH; Cubie HA; Wray D; Department of Oral Medicine and Oral Pathology, University of; Edinburgh.
An HIV-seropositive patient presented with multifocal lesions of both hairy leukoplakia and Kaposi s sarcoma, hairy leukoplakia being present in the epithelium covering the Kaposi s sarcoma lesions. The findings suggest that hairy leukoplakia in immunocompromised patients is both more common and more widely distribute
Biochemistry. 1992 Feb 11;31(5):1458-63. Unique Identifier : AIDSLINE MED/92144552
Dyson HJ; Norrby E; Hoey K; Parks DE; Lerner RA; Wright PE; Department of Molecular Biology, Scripps Research Institute, La; Jolla, California 92037.
Two synthetic peptides corresponding to the N- and C-terminal halves of a 23 amino acid sequence representing an immunodominant domain of the simian immunodeficiency virus of macaque origin (SIVmac) were examined for conformational preferences in aqueous solution by proton nuclear magnetic resonance methods. The two c
Int J Cardiol. 1992 Feb;34(2):139-42. Unique Identifier : AIDSLINE MED/92147267
Horowitz MD; Cox MM; Neibart RM; Blaker AM; Interian A Jr; Division of Thoracic and Cardiovascular Surgery, University of; Miami, Florida.
Although cardiac problems are common in acquired immunodeficiency syndrome, there is limited experience with heart surgery in this group of patients. We report a case in which a right atrial lymphoma was resected to alleviate tricuspid valve obstruction in a patient with AIDS. The patient did well for approximately 7
Tifft CJ; Proia RL; Camerini-Otero RD; Genetics and Biochemistry Branch, National Institute of Diabetes; and Digestive and Kidney Diseases, National Institutes of Health,; Bethesda, Maryland 20892.
Human CD4, a monomeric T cell surface glycoprotein, is required for T helper cell activation and is also the receptor for the human immunodeficiency virus. There have been conflicting reports as to whether glycosylation of CD4 is required for its cell surface expression. To clarify the effect of glycosylation on surfa
Grigoriev M; Praseuth D; Robin P; Hemar A; Saison-Behmoaras T; Dautry-Varsat A; Thuong NT; Helene C; Harel-Bellan A; Laboratoire d'Immunobiologie, Unite de Recherche Associee 1156; Centre National de la Recherche Scientifique, Institut Gustave; Roussy, Villejuif, France.
Oligonucleotide-directed triplex formation within upstream regulatory sequences is envisioned as a potential tool for gene inhibition. However, this approach requires that triple helix-forming oligonucleotides are chemically modified, so that the triplex is stable under physiological conditions. Here, we have compared
Karpatkin S; Nardi M; New York University Medical School, Department of Medicine, New; York 10016.
Autoimmune antiidiotype-like antibody (Ab2) directed against anti-HIV-1gp120 (Ab1) was found in high titer in the sera of 10 consecutive homosexual and 11 narcotic addict HIV-1-related immunologic thrombocytopenia (HIV-1-ITP) patients, was barely detectable in 10 nonthrombocytopenic HIV-1 sero-positive individuals, an
Shirai A; Cosentino M; Leitman-Klinman SF; Klinman DM; Laboratory of Retrovirus Research, Food and Drug Administration,; Bethesda, Maryland 20892.
Peripheral blood lymphocytes (PBL) were obtained from HIV-1-infected patients at different stages of disease. The absolute number of IgM-, IgG-, and IgA-producing lymphocytes per 10(6) PBL was increased 2.8-, 3.4-, and 1.9-fold, respectively, compared with normal controls. 2-17% of IgG-secreting patient cells reacted
Bennett CL; Pascal A; Cvitanic M; Graham V; Kitchens A; DeHovitz JA; Rand Corporation, Santa Monica, California.
This article reports on a study of medical costs of intravenous drug users (IVDUs) with acquired immune deficiency syndrome (AIDS) in Brooklyn, NY, U.S.A. Sociodemographic and clinical data as well as information on medical resource use was gathered for 38 IVDUs with AIDS, all of whom belonged to minority racial/ethni
Stuver SO; Tachibana N; Okayama A; Romano F; Yokota T; Mueller N; Department of Epidemiology, Harvard School of Public Health,; Boston, Massachusetts 02115.
To evaluate determinants of the prevalence of human T-cell leukemia virus type I (HTLV-I) antibody positivity in an endemic region, Miyazaki Prefecture, Japan , demographic and serologic data were collected on 7,055 individuals consecutively seen at Miyazaki City Health Promotion Cen
Del Mistro A; Chotard J; Hall AJ; Whittle H; De Rossi A; Chieco-Bianchi L; Institute of Oncology, University of Padova, Italy.
A seroepidemiological study was conducted, during 1988 and 1989, of mother-child pairs living in The Gambia (West Africa) in order to determine the distribution of the human immunodeficiency viruses type 1 (HIV-1) and type 2 (HIV-2). Specimens were obtained from 931 children (age r
Twenty-nine human immunodeficiency virus type 2 (HIV-2) seropositive women identified in a cross-sectional study in Bissau in 1987 participated in a follow-up study in 1988, where each was matched for age and marital status with two HIV-2 seronegative women. Detailed information about all pregnancies was obtained. The
Itescu S; Mathur-Wagh U; Skovron ML; Brancato LJ; Marmor M; Zeleniuch-Jacquotte A; Winchester R; Institute of Molecular Immunology, Hospital for Joint Diseases,; New York New York.
To investigate the influence of HLA specificities on the rate of progression and outcome of human immunodeficiency virus (HIV) infection, we performed (a) a case-control study in 1989-1990 of HIV-seropositive individuals stratified by both risk behavior and ethnic background, (b) a longitudinal cohort study of HIV-inf
Clark AG; Holodniy M; Schwartz DH; Katzenstein DA; Merigan TC; AIDS Clinical Trial Unit, Stanford University, California.
Quantification of human immunodeficiency virus (HIV) proviral DNA in peripheral blood mononuclear cells (PBMC) was performed in 13 HIV-seropositive asymptomatic individuals during 10-24 months by polymerase chain reaction amplification of multiple half-log dilutions of cellular DNA. At enrollment, subjects had a geome
Wolff H; Mayer K; Seage G; Politch J; Horsburgh CR; Anderson D; Department of Obstetrics, Gynecology, and Reproductive Biology,; Brigham and Women's Hospital, Harvard Medical School, Boston,; Massachusetts 02115.
Twenty-eight paired blood and semen samples obtained from human immunodeficiency virus type 1 (HIV-1) seropositive men at various stages of disease progression were evaluated for titer and immunoglobulin (Ig) class by an enzyme-linked immunosorbent assay (ELISA). Blood antibody titers ranged from 40,000 to 4,000,000 w
Altman R; Shahied SI; Pizzuti W; Brandon DN; Anderson L; Freund C; Division of AIDS Prevention and Control, New Jersey Department of; Health, Trenton 08625-0363.
To answer questions related to the usefulness of premarital testing for human immunodeficiency virus type 1 (HIV-1), two blinded or nonlinked HIV-1 serosurveys were done in New Jersey, a state with a high incidence of AIDS, on blood specimens submitted for a premarital serologic test for syphilis. The first survey inv
Ashorn P; Moss B; Berger EA; Department of Biomedical Sciences, University of Tampere,; Finland.
CD4(178)-PE40 is a genetically engineered hybrid toxin containing a portion of human CD4 linked to the translocation and ADP-ribosylation domains of Pseudomonas exotoxin A. In vitro, the molecule has been shown to selectively kill cells expressing the envelope glycoproteins of human immunodeficiency virus (HIV) or sim
Lekutis C; Olshevsky U; Furman C; Thali M; Sodroski J; Dana-Farber Cancer Institute, Department of Pathology, Harvard; Medical School, Boston, Massachusetts 02115.
The carboxyl half of the HIV-1 gp120 glycoprotein, which has been implicated in binding to the CD4 receptor, contains two disulfide bonds linking cysteine residues 378-445 and 385-418. To examine the necessity of these disulfide bonds for the formation and/or maintenance of a gp120 glycoprotein competent for CD4 bindi
Tanaka KE; Hatch WC; Kress Y; Soeiro R; Calvelli T; Rashbaum WK; Rubinstein A; Lyman WD; Department of Pathology, Albert Einstein College of Medicine,; Bronx, NY 10461.
Some neonates with congenital human immunodeficiency virus type 1 (HIV-1) infection exhibit immune dysregulation. This suggests that fetal CD4+ cells, possibly thymocytes, may be infected during gestation. If thymocytes are infected, this may result in a disruption of T-cell differentiation. To examine this hypothesis
J Med Chem. 1992 Feb 7;35(3):533-8. Unique Identifier : AIDSLINE MED/92148812
Secrist JA 3d; Riggs RM; Tiwari KN; Montgomery JA; Kettering-Meyer Laboratory, Southern Research Institute,; Birmingham, Alabama 35255-5305.
A series of 2 ,3 -dideoxy-4 -thionucleoside analogues of purines and pyrimidines, including 4 -thioddI (17), 4 -thioddC (27), and 4 -thioAZT (34), were synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV). A stereospecific synthesis of the 2,3-dideoxy-4-thioribofuranosyl c
J Natl Cancer Inst. 1992 Mar 4;84(5):332-7. Unique Identifier : AIDSLINE MED/92148866
Bills ND; Hinrichs SH; Morgan R; Clifford AJ; Department of Nutrition, University of California, Davis.
BACKGROUND: Transgenic mice carrying the human T-lymphotropic virus type 1 tax1 (transactivator) gene develop peripheral nerve sheath tumors with well-characterized times of onset and tissue involvement. PURPOSE AND METHODS: To evaluate the effect of dietary folic acid on age at tumor onset and on the concentration of
Lindholm PF; Reid RL; Brady JN; Laboratory of Molecular Virology, National Cancer Institute,; Bethesda, Maryland 20892.
The human T-cell leukemia virus type I tax1 gene product is responsible for the increased expression of several cytokine and cellular genes that contain NF-kappa B regulatory sequences. Our laboratory has previously demonstrated that purified, extracellular Tax1 protein induced the nuclear accumulation of NF-kappa B b
Shirazi Y; Pitha PM; Oncology Center, Johns Hopkins University School of Medicine,; Baltimore, Maryland 21231.
In this study, we have analyzed the effect of human alpha interferon (IFN-alpha) on a single replication cycle of human immunodeficiency virus type 1 (HIV-1) infection in the lymphocytic cell line CEM-174, which is highly sensitive to the antiviral effects of IFN. Pretreatment of cells with 50 to 500 U of recombinant
Schuitemaker H; Koot M; Kootstra NA; Dercksen MW; de Goede RE; van Steenwijk RP; Lange JM; Schattenkerk JK; Miedema F; Tersmette M; Central Laboratory, Netherlands Red Cross Blood Transfusion; Service, Amsterdam.
The composition of human immunodeficiency virus type 1 (HIV-1) clonal populations at different stages of infection and in different compartments was analyzed. Biological HIV-1 clones were obtained by primary isolation from patient peripheral blood mononuclear cells under limiting dilution conditions, with either blood
Fukudome K; Furuse M; Imai T; Nishimura M; Takagi S; Hinuma Y; Yoshie O; Shionogi Institute for Medical Science, Osaka, Japan.
We isolated four monoclonal antibodies (MAbs), M38, M101, M104, and C33, which were capable of inhibiting syncytium formation induced in a human T-cell line, MOLT-4-#8, by coculture with human T-cell leukemia virus type 1 (HTLV-1)-positive human T-cell lines. The MAbs had, however, no inhibitory activity on syncytium
Dropulic B; Lin NH; Martin MA; Jeang KT; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, Maryland 20892.
We have designed a ribozyme that cleaves human immunodeficiency virus type 1 (HIV-1) RNA in U5 (at nucleotide +115). This ribozyme was tested in vitro and was found to give efficient and specific digestion of RNA containing the HIV-1 U5 sequence. When the U5 ribozyme was placed into the HIV-1 genome, virus replication
Locardi C; Puddu P; Ferrantini M; Parlanti E; Sestili P; Varano F; Belardelli F; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.
In this article, we report the establishment of persistent HIV type 1 infection of normal Swiss mice after a single intraperitoneal injection with high-producing HIV-infected U937 cells. Anti-HIV antibodies were found more than 500 days after the original injection, and p24 antigenemia was detected in approximately 50
Rounseville MP; Kumar A; Graduate Program in Genetics, George Washington University; Medical Center, Washington, D.C. 20037.
Human immunodeficiency virus type 1 (HIV-1) transcription is regulated by both viral and host cell factors. Although the viral trans-activator protein, Tat, and its cis-responsive element, trans-activation-responsive (TAR) RNA, have been identified and characterized, the mechanism of HIV-1 transcriptional regulation h
Lee WR; Yu XF; Syu WJ; Essex M; Lee TH; Department of Cancer Biology, Harvard University School of Public; Health, Boston, Massachusetts 02115.
Amino acid substitutions were introduced into four conserved N-linked glycosylation sites of the human immunodeficiency virus type 1 envelope transmembrane glycoprotein, gp41, to alter the canonical N-linked glycosylation sequences. One altered site produced a severe impairment of viral infectivity, which raises the p
Pomerantz RJ; Seshamma T; Trono D; Department of Medicine, Jefferson Medical College, Thomas; Jefferson University, Philadelphia, Pennsylvania 19107.
The Rev protein of human immunodeficiency virus type 1 (HIV-1) is essential for the expression of the structural genes of HIV-1. To determine whether a functional threshold level of Rev is required to allow efficient HIV-1 replication, CD4-positive HeLa cells, constitutively expressing a Rev-deficient provirus, were t
Med J Aust. 1992 Feb 17;156(4):286-7. Unique Identifier : AIDSLINE MED/92149458
Lumb R; Shaw D; Division of Clinical Microbiology, Institute of Medical and; Veterinary Science, Adelaide, SA.
OBJECTIVE: To report a case of progressive disease caused by Mycobacterium bovis after BCG vaccination in a patient asymptomatically infected with the human immunodeficiency virus (HIV). CLINICAL FEATURES: A 34-year-old white man about to commence employment as a developmental care worker had a BCG vaccination. Five m
From September 1990 through August 1991, 2655 (49%) of the 5457 women reported with acquired immunodeficiency syndrome (AIDS) in the United States had been injecting-drug users (IDUs), and 1136 (21%) had had sexual intercourse with men who were IDUs (1). During the same period, 413 (56
BACKGROUND. Since 1985, donors of organs or tissues for transplantation in the United States have been screened for human immunodeficiency virus type 1 (HIV-1), and more than 60,000 organs and 1 million tissues have been transplanted. We describe a case of transmission of HIV-1 by tran
Stambough JL; VanLoveren HR; Cheeks ML; Spine Service, University of Cincinnati School of Medicine, Ohio.
Compression of the spinal cord secondary to disc disorders in Scheuermann s kyphosis is rare. This review reports an unusual case emphasizing mechanisms of compression of the spinal cord from this disc disorder. Contrasts and comparisons with previously published cases are included.
Stratton P; Mofenson LM; Willoughby AD; Pediatric, Adolescent and Maternal AIDS Branch, National; Institute of Child Health and Human Development, Bethesda,; Maryland.
The federal government supports a nationwide network of medical centers to evaluate promising therapies against the human immunodeficiency virus (HIV) and the opportunistic infections and cancers that characterize AIDS. Forty-five obstetricians from the 49 medical centers receiving federal research support for the con
Sperling RS; Stratton P; Department of Obstetrics, Gynecology, and Reproductive Science,; Mount Sinai Medical Center, New York, New York.
The increasing seroprevalence of human immunodeficiency virus (HIV) among women of reproductive age and the risks of vertical transmission of HIV have led to recommendations for routine prenatal HIV counseling and testing. The incentive to undergo such testing is related not only to fetal concerns, but also to the pot
Pa Med. 1992 Jan;95(1):18-9. Unique Identifier : AIDSLINE MED/92150063
Pazin GJ; University of Pittsburgh School of Medicine.
The last installment in this series dealt with post-test counseling of a person whose HIV test was negative. The plan was to provide counseling for an HIV-infected person in this installment. NBA basketball star Magic Johnson s surprise announcement on November 7, 1991, of his infection with HIV has provided an unexpe
Berkhout B; Department of Virology, University of Amsterdam, The Netherlands.
A comparative analysis of TAR RNA structures in human and simian immunodeficiency viruses reveals the conservation of certain structural features despite the divergence in sequence. Both the TAR elements of HIV-1 and SIV-chimpanzee can be folded into relatively simple one-stem hairpin structures. Chemical and RNAase p
Public Health Rep. 1992 Jan-Feb;107(1):100-5. Unique Identifier : AIDSLINE MED/92150635
Marks G; Richardson JL; Ruiz MS; Maldonado N; University of Southern California School of Medicine, Department; of Preventive Medicine, Los Angeles 90033.
The researchers studied the self-reported practices of men infected with the human immunodeficiency virus (HIV) in Los Angeles concerning notifying past sexual partners of their risk of infection. The sample of 111 men consisted of 87 Hispanics, 14 whites, 9 blacks, and 1 Asian. Ninety-three percent identified themsel
Public Health Rep. 1992 Jan-Feb;107(1):105-9. Unique Identifier : AIDSLINE MED/92150636
Jeffery RW; Burke GL; Schmid TL; Ma J; Division of Epidemiology, School of Public Health, University of; Minnesota, Minneapolis 55454-1015.
This study evaluated a methodology for obtaining information on the prevalence of risk behaviors for human immunodeficiency virus infection (HIV) in the general population. From two census tracts in an upper midwestern urban community, 334 households were identified at random. One adult between the ages of 18 and 55 y
Glucocorticosteroids are the most commonly used immunosuppressive agents. In the following review important mechanisms of action of glucocorticoids on the immunological network are summarized, the relationship between duration of therapy, daily dose and incidence of infections is analysed, and evidence is presented th
Science. 1992 Feb 7;255(5045):723-6. Unique Identifier : AIDSLINE MED/92151094
Chow SA; Vincent KA; Ellison V; Brown PO; Department of Pediatrics, Stanford University Medical Center, CA; 94305.
In retroviral integration, the viral integration protein (integrase) mediates a concerted DNA cleavage-ligation reaction in which the target DNA is cleaved and the resulting 5 ends of target DNA are joined to the 3 ends of viral DNA. Through an oligonucleotide substrate that mimics the recombination intermediate for
Ulin PR; AIDSTECH Division, Family Health International, Durham, NC 27709.
Trends in the incidence of HIV/AIDS infection among women in Sub-Saharan Africa suggest this population is increasingly at risk. Many of the same factors that have predisposed rural African women to ill health in the past now increase their vulnerability to AIDS, including poverty and malnutrition, uncontrolled fertil
Pickering H; Todd J; Dunn D; Pepin J; Wilkins A; Medical Research Council, Banjul, The Gambia.
The social backgrounds and working behaviour of 248 prostitutes in urban and rural areas of The Gambia were investigated. Prostitutes were found to be highly mobile, moving frequently between a number of working locations in The Gambia and neighbouring
South Med J. 1992 Feb;85(2):184-6. Unique Identifier : AIDSLINE MED/92151138
Feinberg BB; Soper DE; Department of Obstetrics and Gynecology, Medical College of; Virginia, Virginia Commonwealth University, Richmond.
We have described a case of miliary tuberculosis, with symptoms primarily due to hepatic involvement during pregnancy. Liver biopsy showed granulomatous hepatitis, and subsequent cultures of sputum, urine, and gastric aspirate were positive for Mycobacterium tuberculosis. Although this patient was seronegative for HIV
Magid D; Fishman EK; Russell H. Morgan Department of Radiology and Radiological; Science, Johns Hopkins Medical Institutions, Baltimore, MD 21205.
The CT appearances of various musculoskeletal infections found in patients with AIDS are illustrated. Recognition of these infections is important for management of patients, but conventional laboratory tests may be inadequate in screening for infection or confirming the response of the host to therapy. As a screening
Alpers CE; McClure J; Bursten SL; Department of Pathology, University of Washington School of; Medicine, Seattle.
Human immunodeficiency virus-associated nephropathy (HIVAN) is a recognized clinical entity of unknown pathogenesis. A role for viral infection of renal cells in the initiation of this process at present is an intriguing but untested hypothesis. Studies in primate models of acquired immunodeficiency syndrome (AIDS) su
Am J Public Health. 1992 Feb;82(2):220-4. Unique Identifier : AIDSLINE MED/92152343
Chu SY; Peterman TA; Doll LS; Buehler JW; Curran JW; Division of HIV/AIDS, Centers for Disease Control, Atlanta, GA; 30333.
BACKGROUND. Homosexual and bisexual men with acquired immunodeficiency syndrome (AIDS) differ, and bisexual men play an important role in the sexual transmission of human immunodeficiency virus (HIV) to women. METHODS. To describe AIDS in these groups, we examined AIDS cases reported nationally through June 1990. RESU
Am J Public Health. 1992 Feb;82(2):225-8. Unique Identifier : AIDSLINE MED/92152344
Barr JK; Waring JM; Warshaw LJ; New York Business Group on Health, Inc., NY 10017-6763.
BACKGROUND. We examined the relationship between workplace AIDS education efforts and workers knowledge about HIV transmission and their attitudes toward coworkers with AIDS. METHODS. Questionnaires were mailed to corporate and public service workers at 12 work sites to ascertain the extent of their knowledge about A
Am J Public Health. 1992 Feb;82(2):254-6. Unique Identifier : AIDSLINE MED/92152350
Capell FJ; Vugia DJ; Mordaunt VL; Marelich WD; Ascher MS; Trachtenberg AI; Cunningham GC; Arnon SS; Kizer KW; California Department of Health Services.
The incidence of acquired immunodeficiency syndrome (AIDS) is increasing among California heterosexuals and children. To assess human immunodeficiency virus (HIV)-1 infection in childbearing women, we conducted a blinded serosurvey of newborns. Dried blood specimens taken from 99% of California births during the third
OBJECTIVE: To determine the quantitative microbiologic response and the clinical response of patients with Mycobacterium avium complex bacteremia and AIDS to an oral antimycobacterial regimen. DESIGN: A phase II, multicenter clinical trial. SETTING: Four university-affiliated medical centers. PATIENTS: Forty-one patie
Smith KJ; Skelton HG; Yeager J; Angritt P; Wagner K; James WD; Giblin WJ; Lupton GP; Department of Dermatopathology, Armed Forces Institute of; Pathology, Washington, DC 20306.
BACKGROUND AND DESIGN--The hemophagocytic syndrome (HPS) is characterized by fever, wasting, generalized lymphadenopathy, hepatosplenomegaly, and pancytopenia, often with associated coagulopathy. The most common cutaneous manifestations are panniculitis and purpura. Cytophagic histiocytic panniculitis fits within the
Smith KJ; Skelton HG 3d; Yeager J; James WD; Wagner KF; Department of Dermatopathology, Armed Forces Institute of; Pathology, Washington, DC 20306.
BACKGROUND AND DESIGN--Molluscum contagiosum in acquired immunodeficiency disease, although not life threatening, is often a marker of late-stage disease and may lead to disfiguring cutaneous lesions. Although most current therapy results in at least temporary clearing of individual lesions, lesions frequently recur a
Berrios DC; Hearst N; Perkins LL; Burke GL; Sidney S; McCreath HE; Hulley SB; Center for AIDS Prevention Studies, San Francisco, CA 94105.
We surveyed men and women aged 21 to 34 years to determine the rates of human immunodeficiency virus (HIV) antibody testing in blacks and whites of diverse education levels in four US cities. Responses to the anonymous, mailed questionnaire were received from 90% of 777 white women, 64% of 734 black women, 79% of 677
Biochem Pharmacol. 1992 Jan 22;43(2):197-206. Unique Identifier : AIDSLINE MED/92153188
Kierdaszuk B; Bohman C; Ullman B; Eriksson S; Medical Nobel Institute, Department of Biochemistry I, Karolinska; Institute, Stockholm, Sweden.
Deoxycytidine (dCyd) kinase has been purified to homogeneity from human leukemic spleen, and the capacity of the enzyme to phosphorylate 2 ,3 -dideoxynucleoside (ddN) analogs that are clinically effective inhibitors of human immunodeficiency virus (HIV) replication was evaluated. Cytosine-containing ddN analogs, such
Weber AL; Department of Radiology, Massachusetts Eye and Ear Infirmary,; Boston 02114.
Salivary gland diseases are very common disorders and require radiologic evaluation. Several radiologic methods are used for assessment of these diseases. Conventional films of the parotid and submandibular glands demonstrate opaque stones in the duct system, whereas sialography depicts nonopaque stones, provides addi
Rauch RA; Bazan C 3d; Jinkins JR; Department of Radiology, University of Texas Health Science; Center, San Antonio 78284-7800.
Acquired immunodeficiency syndrome (AIDS) and AIDS-related infection of the brain constitute a large fraction of the most recent research into central nervous system infection. Two major areas of controversy discussed in the past year s literature were the neuroradiologic and neurologic manifestations of early human i
Scotti G; Falini A; Ospedale San Raffaele, University of Milan School of Medicine,; Italy.
Research in diagnosing and understanding brain tumors in neuroradiology is influenced by the investigative tools available to neuroradiologists. CT has represented the gold standard for the past two decades. The role of angiography has become complementary; relevant in the therapeutic phase of embolization of meningio
Neuroimaging of degenerative brain disorders has continued to advance, primarily with MR imaging, single-photon emission CT, and positron emission tomography. Information gained from these morphologic and functional imaging studies provides insight into the pathologic and pathophysiologic changes associated with these
Holzemer WL; Henry SB; Department of Mental Health, Community, and Administrative; Nursing, School of Nursing, University of California, San; Francisco.
The number and type of activated patient problems and the number of nursing interventions in computer-supported and manually-generated nursing care plans for Human Immunodeficiency Virus (HIV) infected patients hospitalized for Pneumocystis carinii pneumonia (PCP) were compared. There were significantly more activated
Wood CL; School of Nursing, University of Maine, Orono.
A multidisciplinary team has developed a computer-based software program for educating nursing students and other college students about six sexually transmitted diseases (STDs). The program for educating about Acquired Immune Deficiency Syndrome (AIDS) is the first of the six Smartbooks to be completed, using the Hyp
Cancer. 1992 Mar 1;69(5):1259-67. Unique Identifier : AIDSLINE MED/92154576
Ohsaka A; Saito K; Sakai T; Mori S; Kobayashi Y; Amemiya Y; Sakamoto S; Miura Y; Department of Medicine, Jichi Medical School, Tochigiken, Japan.
The clinicopathologic features of 14 patients with angioimmunoblastic lymphadenopathy (AIL)-related lesions were analyzed. Lymph node biopsy specimens from all the patients showed a diffuse obliteration of lymph node architecture, prominent vascular proliferation, a polymorphous cellular infiltrate, including immunobl
FASEB J. 1992 Feb 1;6(3):840-4. Unique Identifier : AIDSLINE MED/92155475
Barnett LA; Fujinami RS; Department of Neurology, University of Utah, Salt Lake City; 84132.
Many mechanisms may account for immune-mediated pathology after viral infections. Although several means have been hypothesized to play a role in disease, a widely accepted mechanism for viral-induced autoimmunity is molecular mimicry. It is thought that damage could result from an immune response to similar regions s
Turnicky RP; Goodin J; Smialek JE; Herskowitz A; Beschorner WE; Department of Pathology, Johns Hopkins University School of; Medicine, Baltimore, MD.
Human immunodeficiency virus (HIV)-associated myocarditis is well reported. Many of these patients are also intravenous (IV) drug abusers. This study examined sudden death victims from the Office of the Chief Medical Examiner, State of Maryland, for active myocarditis. A group of HIV-negative drug abusers is compared
Jacques C; Richmond G; Tierney L; Curtis JL; McKerrow J; Warnock ML; Anatomic Pathology Service, Department of Veterans Affairs; Medical Center, San Francisco, CA.
We describe clinical and postmortem findings in a 44-year-old man with pulmonary hypertension and infection with the human immunodeficiency virus (HIV-1). Plexogenic angiopathy and veno-occlusive lesions were present, in addition to a mild, patchy pulmonary interstitial lymphoid infiltrate. The clinical data for 14 pr
Pajor AM; Wright EM; Department of Physiology, UCLA School of Medicine 90024-1751.
Complementary DNAs encoding seven different proteins related to the rabbit intestinal Na+/glucose cotransporter, SGLT1, were isolated from a rabbit renal cDNA library at relatively high stringency. The messages for RK-B to RK-F were single mRNA species at 2.3 kilobases (kb) in heart and kidney. The message for RK-A wa
Norbiato G; Bevilacqua M; Vago T; Baldi G; Chebat E; Bertora P; Moroni M; Galli M; Oldenburg N; Servizio di Endocrinologia, Ospedale L. Sacco Vialba, Milan,; Italy.
This study concerns 9 iv drug abusers with acquired immunodeficiency syndrome (AIDS) who developed hypercortisolism without the clinical signs or metabolic consequences of hypercortisolism. All patients were characterized by an Addisonian picture (weakness, weight loss, hypotension, hyponatremia, and intense mucocutan
Stagnaro-Green A; Roman SH; Cobin RH; el-Harazy E; Wallenstein S; Davies TF; Department of Medicine, Mount Sinai School of Medicine, New York,; New York 10029.
Immune function in normal pregnancy and the postpartum period remains poorly defined. We hypothesized that a comparative study between pregnant women with normal and abnormal immune function would further our understanding of the immune mechanisms of pregnancy. We chose to study a cohort of pregnant women at risk for
Allen CM; Section of Diagnostic Services, Ohio State, University College of; Dentistry, Columbus 43210.
The red to white lesions of oral candidiasis are easily treated with any of several antifungal medications. But predisposing systemic conditions, such as diabetes mellitus or human immunodeficiency virus infection, should be ruled out as contributing factors.
Roulston A; D'Addario M; Boulerice F; Caplan S; Wainberg MA; Hiscott J; Lady Davis Institute for Medical Research, Quebec, Canada.
The effects of human immunodeficiency virus 1 (HIV-1) infection on cellular differentiation and NF-kappa B DNA binding activity have been investigated in a new model of myeloid differentiation. PLB-985 cells represent a bipotential myelomonoblastic cell population capable of either granulocytic or monocytic differenti
Nyamathi A; School of Nursing, University of California, Los Angeles; 90024-1702.
A comparative study was conducted to assess factors that relate to level of HIV risk of black homeless women. The study examined whether 460 black women categorized as high, moderate, or low risk for HIV infection differed in environmental, demographic, and personal factors; appraisal of threat; resources; coping resp
Collier AC; Marra C; Coombs RW; Claypoole K; Cohen W; Longstreth WT Jr; Townes BD; Maravilla KR; Critchlow C; Murphy VL; et al; Department of Medicine, University of Washington School of; Medicine, Seattle.
To characterize neurological and neuropsychological findings associated with human immunodeficiency virus type-I (HIV) infection, 77 seropositive homosexual or bisexual males with no or minor symptoms of HIV were compared prospectively to 44 HIV seronegative men by observers blinded to serological status of the subjec
Gallicano KD; Tobe S; Sahai J; McGilveray IJ; Cameron DW; Kriger F; Garber G; Health & Welfare Canada, Bureau of Drug Research, Ottawa,; Ontario.
The effect of continuous ambulatory peritoneal dialysis (CAPD) on zidovudine (ZDV) elimination was studied in two HIV-positive men. Serum and dialysate samples were collected after a single oral dose of 200 mg (patient 1) or 100 mg (patient 2) of ZDV, and again on at least one occasion during chronic therapy (100 mg e
Oh SK; Cruikshank WW; Raina J; Blanchard GC; Adler WH; Walker J; Kornfeld H; Department of Microbiology, Boston University School of Medicine,; Massachusetts.
Binding of the human immunodeficiency virus type 1 (HIV-1) external envelope glycoprotein (gp120) has been reported to alter the function and surface antigen expression of lymphocytes and monocytes in vitro. To determine whether these in vitro findings could be relevant in vivo, we searched for the presence of this an
Buehler JW; Berkelman RL; Stehr-Green JK; Division of HIV/AIDS, National Center for Infectious Diseases,; Centers for Disease Control, Atlanta, Georgia 30333.
AIDS surveillance data are widely used in setting HIV intervention policies, and the effectiveness of these data depend on their completeness. We reviewed studies conducted by state and local health departments on the completeness of AIDS reporting. These studies identified AIDS cases through alternate data sources, s
Mohar A; De Gruttola V; Mueller N; Sepulveda J; Department of Epidemiology, Instituto Nacional de Cancerologia,; Mexico City.
As in many developing countries, the AIDS epidemic in Mexico has become a major public health problem. Given the competition for scarce health resources in Mexico, where hospitals are overcrowded and care for AIDS patients is often unavailable, planning depends on accurate estimate
Comeau AM; Harris JA; McIntosh K; Weiblen BJ; Hoff R; Grady GF; Theobald Smith Research Institute, Inc., Jamaica Plain, MA 02130.
The polymerase chain reaction (PCR) for human immunodeficiency virus (HIV) was evaluated using coded blood specimens from infants whose clinical status is now known. A micromethod for the efficient isolation of mononuclear cells from small volumes of blood, and definitions of PCR positivity that took into account the
Maternal human immunodeficiency virus type 1 (HIV-1) infection in sub-Saharan Africa is a major public health concern because of the high prevalence among women of childbearing age and the poor prognosis for perinatally infected children. Characteristics associated with HIV seroprevalence were studied in a population
Grankvist O; Bredberg-Raden U; Gustafsson A; Albert J; Albino P; Andreasson PA; Naucler A; Biberfeld G; Wadell G; Department of Virology, University of Umea, Sweden.
A two-step polymerase chain reaction (PCR), with four double (nested) primer pairs, used for the detection of HIV-2 in clinical samples is described. With these four nested primer pairs we could detect HIV-2 DNA in 17 of 17 virus isolates and in blood mononuclear cell samples from 31 of 37 (83.7%) seropositive individ
Arendrup M; Nielsen C; Hansen JE; Pedersen C; Mathiesen L; Nielsen JO; Department of Infectious Diseases, Hvidovre Hospital, University; of Copenhagen, Denmark.
The capacity of consecutive human sera to neutralize sequentially obtained autologous virus isolates was studied. HIV-1 was isolated three times over a 48-164-week period from three individuals immediately after seroconversion and from two individuals in later stages of infection. Development of neutralizing antibodie
Obaru K; DeClue JE; Haseltine WA; Division of Human Retrovirology, Dana-Farber Cancer Institute,; Harvard Medical School, Boston, Massachusetts.
The nef protein of the BH8 clone derived from the IIIB isolate of human immunodeficiency virus 1 (HIV-1) has a molecular weight of 27,000, whereas that produced by a clone of the BRU strain of HIV-1 appears to have a molecular weight of 24,800. To determine the basis for this difference in molecular weight, a series o
Peden KW; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892.
Plasmid proviral molecular clones of the LAI isolate of HIV-1 and the ROD isolate of HIV-2 were originally prepared in moderate copy number plasmids derived from pBR322, which contains the colE1 origin of replication. In these plasmid vectors, the HIV sequences are stable to continuous passage in bacteria. However, wh
Gooding GA; Sooy CD; Hybarger CP; Department of Radiology, University of California, San Francisco.
Bilateral cystic parotid glands occur in some cases of human immunodeficiency virus (HIV) infection. This abnormality, which is associated with cervical adenopathy, can be defined by sonography in the superficial gland, as noted in three men. In retrospect, this parotid disease has similarity to the sonographic findin
From June 1981 through December 1991, 34% of all reported cases of acquired immunodeficiency syndrome (AIDS) among women in the United States were attributed to heterosexual transmission, and that proportion has been increasing steadily (1). Factors associated with an increased risk fo
Nature. 1992 Feb 20;355(6362):728-30. Unique Identifier : AIDSLINE MED/92158079
Emini EA; Schleif WA; Nunberg JH; Conley AJ; Eda Y; Tokiyoshi S; Putney SD; Matsushita S; Cobb KE; Jett CM; et al; Merck, Sharp and Dohme Research Laboratories, West Point,; Pennsylvania 19486.
The acquired immunodeficiency syndrome (AIDS) is the late-stage clinical manifestation of long-term persistent infection with the human immunodeficiency virus type 1 (HIV-1). Immune responses directed against the virus and against virus-infected cells during the persistent infection fail to mediate resolution of the i
Ned Tijdschr Geneeskd. 1992 Feb 8;136(6):285-8. Unique Identifier : AIDSLINE MED/92158098
Wigersma L; Universiteit van Amsterdam, vakgroep Huisartsgeneeskunde.
OBJECTIVE. To describe general practitioners approach to and management of urethritis in men, and to compare this with a general practice protocol for urethritis. DESIGN. Descriptive. SETTING. General practices in Amsterdam. PATIENTS AND METHODS. In 13 general practices in Amsterdam (23,510 patients, of whom 11,627 m
McDonnell PC; Kumar S; Rabson AB; Gelinas C; Center for Advanced Biotechnology and Medicine, Piscataway, New; Jersey 08854-5638.
Our studies originally demonstrated that the v-rel oncoprotein repressed gene expression in chicken lymphoid cells, while it activated transcription in rodent fibroblasts. Here we report that the c-rel protein can activate expression of genes linked to kappa B motifs when low levels of endogenous kappa B-binding activ
Liaw YC; Gao YG; Marquez VE; Wang AH; Department of Physiology & Biophysics, University of Illinois,; Urbana 61801.
The x-ray crystal structures of two new anti-HIV compounds, 9-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl)adenine (2 -F-dd-araA) and 9-(2,3-dideoxy-2-fluoro-beta-D-threo- pentofuranosyl)hypoxanthine (2 -F-dd-aral), have been determined at two temperatures. Both crystals are in the space group P2(1)2(1)2(1), and
Meyerhans A; Vartanian JP; Wain-Hobson S; Laboratoire de Retrovirologie Moleculaire, Institut Pasteur,; Paris, France.
A method for the amplification of a single DNA strand at low copy number is described. It is a wholly PCR based approach which involves an initial linear amplification of the target using a tagged strand specific primer. This is followed by classical PCR amplification of the progeny using a pair of primers, one specif
Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1335-9. Unique Identifier : AIDSLINE MED/92159044
Turner S; Tizard R; DeMarinis J; Pepinsky RB; Zullo J; Schooley R; Fisher R; Department of Molecular Biology, Cambridge, MA 02142.
Recombinant soluble CD4 (rsCD4) has potent antiviral activity against cell line-adapted isolates of the human immunodeficiency virus type 1 (HIV-1) but low activity toward HIV-1 primary isolates from patients. A simple hypothesis proposed to explain this discrepancy, which questions the therapeutic utility of soluble
Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1487-91. Unique Identifier : AIDSLINE MED/92159074
Karpatkin S; Nardi MA; Kouri YH; Department of Medicine, New York University Medical Center, NY; 10016.
Anti-CD4 antibody was found in 30% of human immunodeficiency virus (HIV-1)-seropositive thrombocytopenic patients compared with 5% of nonthrombocytopenic seropositive patients (chi 2 = 21.7, P less than 0.001) and was shown by the following observations to contain internal-image anti-idiotype antibody (Ab2) directed a
Zaitseva MB; Moshnikov SA; Kozhich AT; Frolova HA; Makarova OD; Pavlikov SP; Sidorovich IG; Brondz BB; All-Union Cancer Research Center, Academy of Medical Sciences,; Moscow, USSR.
Seventy-five per cent of sera from HIV-1-infected individuals bind to the human B-lymphoma cells bearing the major histocompatibility class II molecule in enzyme-linked immunosorbent assay (ELISA). The binding is caused by the antibodies against the class II molecule present in the serum samples which prevent the inte
Gabrilovich DI; Kozich AT; Moshnikov SA; Pokrovsky VV; Laboratory of AIDS Epidemiology and Prevention, Central Institute; of Epidemiology, USSR Ministry of Public Health, Moscow.
The binding of the synthetic fragment from the CD4 binding site of HIV (gp 120) with polymorphonuclear neutrophils (PMN) in 13 healthy donors and 31 HIV-infected patients was studied using a biotin-streptavidin-texas-red complex. The largest percentage of PMN-bound peptide was reached at a final peptide concentration
Between 1988/89 1207 HIV-positive patients were registered at the Medical Policlinic of the University Hospital Zurich. In 57 of these patients colonoscopy or rectosigmoidoscopy was performed because of serious symptoms or symptoms refractory to therapy (diarrhea, bloody diarrhea, massive abdominal pain, weight loss).
Hill JA; Anderson DJ; Department of Obstetrics, Gynecology and Reproductive Biology,; Brigham and Women's Hospital, Boston, MA.
OBJECTIVES: The purpose of this study was to quantify, characterize, and further define the role of vaginal white blood cells in defense mechanisms and human immunodeficiency virus infection. STUDY DESIGN: Vaginal lavages were obtained from five healthy women throughout three menstrual cycles. Lymphocyte subpopulation
Am J Psychiatry. 1992 Mar;149(3):396-8. Unique Identifier : AIDSLINE MED/92160981
McKegney FP; O'Dowd MA; Department of Psychiatry, Albert Einstein College of; Medicine/Montefiore Medical Center, Bronx, NY 10467.
Among psychiatric consultation patients, 322 AIDS patients were significantly less suicidal than 82 other HIV-positive patients and were comparable in suicidality to 1,086 patients with negative or unknown HIV status. AIDS patients had significantly more organic mental disorders. Organicity, denial, acceptance, and/or
Am J Public Health. 1992 Jan;82(1):70-3. Unique Identifier : AIDSLINE MED/92161047
Roberts CR; Fipps DR; Brundage JF; Wright SE; Goldenbaum M; Alexander SS; Burke DS; Division of Retrovirology, Walter Reed Army Institute of; Research, Rockville, MD 20850.
BACKGROUND. The wide range in human T-lymphotropic virus (HTLV) seroprevalences reported worldwide has made estimates of seroprevalence difficult in unique populations. In this study, the seropositivity of young adult civilian applicants for the US Armed Forces was determined. METHODS. Serum samples from nine geograph
Am J Public Health. 1992 Mar;82(3):372-7. Unique Identifier : AIDSLINE MED/92161063
Jemmott JB 3d; Jemmott LS; Fong GT; Department of Psychology, Princeton University, NJ 08544-1010.
BACKGROUND. The number of reported cases of acquired immune deficiency syndrome (AIDS) is increasing disproportionately among Blacks in the United States . The relatively high incidence of sexually transmitted diseases among Black adolescents suggest the need for AIDS prevention program
Am J Public Health. 1992 Mar;82(3):453-5. Unique Identifier : AIDSLINE MED/92161082
Swan JH; Benjamin AE; Brown A; Institute for Health Policy Studies, University of California,; San Francisco.
We compared average daily hours of care for patients with and without acquired immunodeficiency syndrome (AIDS) in a hospital-based skilled nursing facility. Patients with AIDS averaged over an hour more direct nursing care per patient day (6.5 vs 5.4 hours). These findings support other reports of greater nursing tim
Foley FW; Traugott U; LaRocca NG; Smith CR; Perlman KR; Caruso LS; Scheinberg LC; Department of Neurology, Albert Einstein College of Medicine,; Bronx, NY 10461.
This study examined psychologic distress and immune function in patients with chronic-progressive multiple sclerosis participating in a placebo-control trial of cyclosporine. Immune measures included percentages and absolute numbers of CD2+, CD4+, CD8+, Leu-11-b+, HLA-DR (IA+), and transferrin-receptor-positive cells,
Laman JD; Schellekens MM; Abacioglu YH; Lewis GK; Tersmette M; Fouchier RA; Langedijk JP; Claassen E; Boersma WJ; Department of Immunology and Medical Microbiology, TNO Medical; Biological Laboratory, Rijswijk, The Netherlands.
The third variable (V3) domain of the human immunodeficiency virus type 1 (HIV-1) external membrane glycoprotein gp120 is of crucial importance in eliciting neutralizing antibodies in infected persons. Polyclonal (PAb) and monoclonal (MAb) antibodies directed against selected epitopes in the V3 domain are valuable too
Science. 1992 Jan 24;255(5043):456-9. Unique Identifier : AIDSLINE MED/92132551
Hu SL; Abrams K; Barber GN; Moran P; Zarling JM; Langlois AJ; Kuller L; Morton WR; Benveniste RE; Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle,; WA 98121.
Simian immunodeficiency virus (SIV) is a primate lentivirus related to human immunodeficiency viruses and is an etiologic agent for acquired immunodeficiency syndrome (AIDS)-like diseases in macaques. To date, only inactivated whole virus vaccines have been shown to protect macaques against SIV infection. Protective i
Holodniy M; Winters MA; Merigan TC; Center for AIDS Research, Stanford University Med. Ctr., CA; 94305.
We describe in this report the ability to determine human immunodeficiency virus proviral copy number by an automated nonisotopic method. Our system utilizes a FACStarPLUS cell sorter, the GeneAmp PCR System 9600 and a Biomek 1000 robotic workstation. Linking these three machines allows cell populations to be sorted a
Sattler FR; Feinberg J; Department of Medicine, University of Southern California School; of Medicine, Los Angeles.
Pneumocystis carinii pneumonia and therapies to treat this infection are associated with frequent and severe morbidity in patients with acquired immunodeficiency syndrome (AIDS). Mortality rates remain in the 20 to 40 percent range for severe episodes. Thus, less toxic and more effective therapies are needed. For mild
Int J Cancer. 1992 Feb 1;50(3):431-7. Unique Identifier : AIDSLINE MED/92138080
Yasukawa M; Inatsuki A; Yakushijin Y; Kobayashi Y; First Department of Internal Medicine, Ehime University School of; Medicine, Japan.
In order to clarify the cellular tropism of human T-cell leukemia virus type I (HTLV-I) and the effects of HTLV-I infection on T-cell functions, we investigated the infectiousness of HTLV-I on T cells bearing T-cell receptor (TCR) gamma delta and functional alterations of the HTLV-I-infected TCR-gamma delta + T cells.
A group of 63 patients infected by HIV and presenting with CD8 hyperlymphocytosis (CD8+) has been studied. CD8 hyperlymphocytosis was defined by the presence, during at least three months, of at least 1,500 CD8 circulating lymphocytes. The CD8+ patients (n = 63) were identified and followed within the cohort (1,444 pa
Am J Med. 1992 Feb 14;92(2A):30S-35S. Unique Identifier : AIDSLINE MED/92143170
Hardy WD; AIDS Clinical Research Center, University of California, School; of Medicine, Los Angeles.
Herpes simplex virus (HSV) resistant to acyclovir can produce persistent mucocutaneous ulcerative disease in patients with the acquired immunodeficiency syndrome (AIDS). The incidence of clinically significant acyclovir-resistant HSV disease has dramatically increased since the
Blood. 1992 Feb 15;79(4):954-7. Unique Identifier : AIDSLINE MED/92144999
Susal C; Daniel V; Oberg HH; Terness P; Huth-Kuhne A; Zimmerman R; Opelz G; Department of Transplantation Immunology, University of; Heidelberg, Germany.
The contribution of autoimmune phenomena to the pathogenesis of acquired immunodeficiency syndrome (AIDS) is poorly understood. We investigated the relationship between IgG-anti-Fab gamma autoantibodies and the main immunologic feature of AIDS, the decrease of CD4+ helper lymphocytes. Sera of 33 human immunodeficiency
Alonso-Caplen FV; Nemeroff ME; Qiu Y; Krug RM; Department of Molecular Biology and Biochemistry, Rutgers; University, Piscataway, New Jersey 08855-1179.
Influenza virus unspliced NS1 mRNA, like retroviral pre-mRNAs, is efficiently exported from the nucleus and translated in the cytoplasm of infected cells. With human immunodeficiency virus (HIV), the transport of viral pre-mRNAs is facilitated by the viral Rev protein. We tested the possibility that the influenza viru
Am J Pathol. 1992 Feb;140(2):269-75. Unique Identifier : AIDSLINE MED/92152307
Chensue SW; Warmington KS; Berger AE; Tracey DE; Department of Pathology, Veterans Affairs Medical Center, Ann; Arbor, Michigan.
Human interleukin 1 receptor antagonist protein (IRAP) is a specific antagonist of interleukin 1 (IL-1) action in both in vitro and in vivo experimental models. Presently, the significance of this protein in human pathophysiology is unknown. In the present study, monoclonal antibodies against IRAP were prepared and us
Hardie J; Department of Dentistry, Vancouver General Hospital, B.C.
This survey indicates that while the majority of Canadian dental personnel would treat AIDS patients, they are concerned about the transmission of the causative agent and the efficacy of recommended infection control procedures. It is believed that a frank discussion of these reservations and anxieties is essential if
Soukiasian SH; Rice B; Foster CS; Lee SJ; Immunology Service, Massachusetts Eye and Ear Infirmary, Harvard; Medical School, Boston 02114.
The majority of human peripheral blood and lymphoid tissue T cells express the TCR alpha/beta heterodimer, while the TCR gamma/delta is expressed on only a small subset of T lymphocytes. However, the majority of murine intraepithelial lymphocytes and most Thy-1+ murine dendritic epidermal cells express the TCR gamma/d
Lightsey DM; Shah PK; Forrester JS; Michael TA; Institute of Human Physiology, Bakersfield, CA.
Due to fear of transmitted disease, mouth-to-mouth cardiopulmonary resuscitation (CPR) is now rare, even though early CPR is associated with a fivefold to 30-fold increase in survival. The authors have devised a one-piece silicone mask (Kiss of Life [KOL], Brunswick Biomedical Technologies, Inc, Warehom, MA) with a on
Butler GA; Friedman AH; Mount Sinai School of Medicine, New York, NY 10029.
Cytomegalovirus retinitis, the major cause of blindness in patients with the acquired immunodeficiency syndrome, can be arrested by early detection and treatment. We identified 9 screening indices for early CMV retinitis: T-4/T-8 ratio less than 0.11, T-4 count
West J Med. 1992 Jan;156(1):30-5. Unique Identifier : AIDSLINE MED/92132997
Zeldis JB; Jain S; Kuramoto IK; Richards C; Sazama K; Samuels S; Holland PV; Flynn N; Department of Internal Medicine, University of California, Davis,; School of Medicine.
Intravenous drug users are frequently exposed to parenterally transmitted viral infections, and these infections can spread to the general population through sexual activity. We investigated the prevalence of serologic markers for human immunodeficiency virus type 1 (HIV-1), human T-cell lymphotropic virus type I/II (
Katz BZ; Berkman AB; Shapiro ED; Department of Pediatrics, Yale University School of Medicine, New; Haven, Connecticut 06510.
The DNA and nuclear antigens of Epstein-Barr virus (EBV) have been detected in specimens of tissue of non-Hodgkin lymphoma and lymphocytic interstitial pneumonitis from patients with acquired immunodeficiency syndrome. To determine whether there is serologic evidence of an active EBV infection in these disorders, we c
JAMA. 1992 Feb 26;267(8):1100-5. Unique Identifier : AIDSLINE MED/92139527
Lo B; Steinbrook R; Program in Medical Ethics, University of California, San; Francisco.
The tragedy of five patients who contracted human immunodeficiency virus (HIV) infection from a seropositive dentist has alarmed the public. The Centers for Disease Control (CDC) recently revised its recommendations for preventing the transmission of HIV infection to patients during invasive procedures. The CDC abando
Smith MA; Singer C; Department of Medicine, Long Island Jewish Medical Center, New; Hyde Park, New York.
This review has focused on a select group of viruses that can be sexually transmitted. The viruses include the herpesviruses, hepatitis A virus, hepatitis B virus, delta virus, non-A, non-B hepatitis virus(es), and molluscum contagiosum. Their impact on the population alone or in association with HIV disease necessita
Sparger EE; Shacklett BL; Renshaw-Gegg L; Barry PA; Pedersen NC; Elder JH; Luciw PA; Department of Veterinary Medicine, University of California,; Davis 95616.
The long terminal repeat (LTR) of a retrovirus contains sequence elements that constitute a promoter for controlling viral gene expression in infected cells. We have examined regulation of LTR-directed gene expression in feline immunodeficiency virus (FIV), a T-lymphocytopathic lentivirus associated with a fatal AIDS-
Wendell DA; Onorato IM; McCray E; Allen DM; Sweeney PA; Division of HIV/AIDS, Centers for Disease Control, Atlanta, GA; 30333.
Adolescents and young adults are at risk for human immunodeficiency virus type 1 infection due to unprotected sexual intercourse and drug use. In 1988 and 1989, blinded surveys were conducted in 84 sexually transmitted disease clinics, 115 women s health clinics, and 19 drug treatment centers in 38 metropolitan areas.
Am J Med. 1992 Feb 14;92(2A):12S-16S. Unique Identifier : AIDSLINE MED/92143165
Heinemann MH; Ophthalmology Service, Memorial Sloan-Kettering Cancer Center,; New York, New York.
Cytomegalovirus ( CMV ) retinitis is the most common ocular opportunistic infection in patients with acquired immunodeficiency syndrome (AIDS). The disease is inexorably progressive when untreated, making early detection and prompt treatment essential for preserva
Am J Med. 1992 Feb 14;92(2A):17S-21S. Unique Identifier : AIDSLINE MED/92143166
de Smet MD; National Eye Institute, National Institutes of Health, Bethesda,; Maryland 20892.
Patients with acquired immunodeficiency syndrome (AIDS) are at high risk for developing retinitis. The most common forms of retinitis in such patients are those caused by cytomegalovirus ( CMV ) and Toxoplasma; however, retinit
Am J Med. 1992 Feb 14;92(2A):22S-25S. Unique Identifier : AIDSLINE MED/92143167
Polis MA; National Institutes of Health, Bethesda, Maryland 20892.
In a controlled trial of foscarnet in the treatment of cytomegalovirus ( CMV ) retinitis in patients with the acquired immunodeficiency syndrome (AIDS), patients with non-immediately sight-threatening lesions were randomized to
Am J Med. 1992 Feb 14;92(2A):26S-29S. Unique Identifier : AIDSLINE MED/92143168
Jacobson MA; Department of Medicine, University of California, San Francisco; 94110.
The use of ganciclovir in the treatment of cytomegalovirus ( CMV ) retinitis in patients with acquired immunodeficiency syndrome (AIDS) is limited by marrow toxicity and by the development of resistance to this agent in CMV str
Sanborn GE; Anand R; Torti RE; Nightingale SD; Cal SX; Yates B; Ashton P; Smith T; Department of Ophthalmology, University of Texas Southwestern; Medical Center, Dallas 75235-9057.
A surgically implantable device for sustained intravitreal release of ganciclovir has been developed. The device delivers ganciclovir intraocularly over approximately 4 to 5 months. Eight patients with acquired immunodeficiency syndrome (AIDS) and associated cytomegalovirus (
Smith TJ; Pearson PA; Blandford DL; Brown JD; Goins KA; Hollins JL; Schmeisser ET; Glavinos P; Baldwin LB; Ashton P; Department of Ophthalmology, University of Kentucky, Lexington.
Current treatment of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome involves frequent intravenous administration of sodium ganciclovir that often results in unacceptable side effects. We have developed devices that release ganciclovir at rates of 2 mi
AIDS Res Hum Retroviruses. 1992 Jan;8(1):101-6. Unique Identifier : AIDSLINE MED/92144204
Klinman DM; Krieg A; Conover J; Ussery MA; Black PL; Laboratory of Retrovirus Research, CBER, FDA, Bethesda, MD.
Murine acquired immunodeficiency syndrome (MAIDS) develops when C57B1/6 mice are inoculated with LP-BM5 murine leukemia viruses. Disease progression in these animals is characterized by lymphadenopathy, polyclonal B-cell activation, severe immunodeficiency, and death. Mice with MAIDS have been used to examine the effi
AIDS Res Hum Retroviruses. 1992 Jan;8(1):89-95. Unique Identifier : AIDSLINE MED/92144213
Rizvi TA; Panganiban AT; McArdle Laboratory for Cancer Research, University of; Wisconsin-Madison 53706.
In order to study SIV replication over a single round of replication virus particles were generated that contain a replication-defective vector containing a selectable marker. Genetic complementation between an env-deficient SIV variant and plasmid that expresses the env gene of an amphotropic murine retrovirus result
Chen CH; Cheng YC; Department of Pharmacology, Yale University School of Medicine,; New Haven, Connecticut 06510.
2 ,3 -Dideoxycytidine ( ddC ) is a potent inhibitor of human immunodeficiency virus replication in vitro and shows beneficial effects in AIDS therapy. The compound inhibits mitochondrial DNA (mtDNA) synthesis at a clinically relevant concentration, whic
Peterson PK; Gekker G; Chao CC; Hu SX; Edelman C; Balfour HH Jr; Verhoef J; Department of Medicine, Hennepin County Medical Center,; Minneapolis, Minnesota 55415.
Human cytomegalovirus (HCMV) is a potential cofactor in HIV-1 infection. To investigate the mechanism whereby HCMV promotes HIV-1 replication, a PBMC coculture assay which measures HIV-1 p24 antigen release was used as an index of viral replication. HCMV-stimulated PBMC were capabl
Dickover RE; Donovan RM; Goldstein E; Cohen SH; Bolton V; Huth RG; Liu GZ; Carlson JR; Department of Internal Medicine, University of California, Davis.
Better markers are needed to monitor the efficacy of antiretroviral drugs in persons infected with human immunodeficiency virus (HIV). We investigated the effects of zidovudine (ZDV) and dideoxycytidine ( ddC ) on the presence of unintegrated HIV-1 DNA
Battini JL; Heard JM; Danos O; Laboratoire Retrovirus et Transfert Genetique, Institut; Pasteur, Paris, France.
The envelope glycoproteins (SU) of mammalian type C retroviruses possess an amino-terminal domain of about 200 residues, which is involved in binding a cell surface receptor. In this domain, highly conserved amino acid sequences are interrupted by two segments of variable length and sequence, VRA and VRB. We have stud
T-cell subsets were studied by fluorescence-activated cell sorter analysis in 57 feline immunodeficiency virus (FIV)-seropositive cats with naturally acquired FIV infection to see whether CD4(+)-CD8+ alterations were comparable to those observed in human immunodeficiency virus-infected patients. CD4+ values were decre
Walker S; Hagemeier C; Sissons JG; Sinclair JH; Department of Medicine, University of Cambridge, United Kingdom.
Transient gene expression studies have indicated that human cytomegalovirus (HCMV) specifically transactivates the human immunodeficiency virus (HIV) long terminal repeat (LTR). We show here, by a specific mutational analysis, that only the TATA box region is obligatory for transac
Geng YQ; Chandran B; Josephs SF; Wood C; Department of Microbiology, University of Kansas, Lawrence; 66045-2103.
Human herpesvirus 6 (HHV-6) is a lymphotropic herpesvirus, and in vitro, HHV-6 can productively infect many of the same cell types as can human immunodeficiency virus (HIV). Coinfection by both viruses in vitro can lead to both activation of the HIV promoter and acceleration of cytopathic effects. We have previously d
Schubert M; Joshi B; Blondel D; Harmison GG; Laboratory of Viral and Molecular Pathogenesis, National; Institute of Neurological Disorders and Stroke, Bethesda,; Maryland 20892.
Enveloped virus particles carrying the human immunodeficiency virus (HIV) CD4 receptor may potentially be employed in a targeted antiviral approach. The mechanisms for efficient insertion and the requirements for the functionality of foreign glycoproteins within viral envelopes, however, have not been elucidated. Cond
Ciminale V; Pavlakis GN; Derse D; Cunningham CP; Felber BK; Human Retrovirus Section, National Cancer Institute, Frederick; Cancer Research and Development Center, Maryland 21702-1201.
Novel cytoplasmic mRNA species produced by human T-cell leukemia virus type I (HTLV-I) were cloned by using the polymerase chain reaction technique. Five novel 3 splice sites located in the X region and upstream of the env gene were identified. Splicing to the 3 splice sites in the X region generates mRNAs that expr
Burstein H; Bizub D; Kotler M; Schatz G; Vogt VM; Skalka AM; Institute for Cancer Research, Fox Chase Cancer Center,; Philadelphia, Pennsylvania 19111.
The avian sarcoma and leukosis viruses (ASLV) encode a protease (PR) at the C terminus of gag which in vivo catalyzes the processing of both gag and gag-pol precursors. The studies reported here were undertaken to determine whether PR is able to cleave these polyproteins while it is still part of the gag precursor or
Elder JH; Lerner DL; Hasselkus-Light CS; Fontenot DJ; Hunter E; Luciw PA; Montelaro RC; Phillips TR; Department of Molecular Biology, Scripps Research Institute, La; Jolla, California 92037.
The nonprimate lentiviruses feline immunodeficiency virus, equine infectious anemia virus, visna virus, and caprine encephalitis virus contain a gene segment in the polymerase gene that is lacking in the primate lentiviruses. A related sequence has been noted in other retroviruses, most notably the type D retroviruses
Johnson JC; Burnett AF; Willet GD; Young MA; Doniger J; Department of Obstetrics and Gynecology, Georgetown University; Medical Center, Washington, DC.
In 32 human immunodeficiency virus (HIV)-infected women, routine gynecologic examination was performed with colposcopy and Papanicolaou smear; cervical swabs were collected for human papillomavirus (HPV) DNA screening and typing; and immune status was assessed by CD4 T-cell count. Dot blot analysis was specifically ch
Ouellette DR; Kelly JW; Anders GT; Department of Pulmonary/Critical Care Medicine, Fitzsimons Army; Medical Center, Aurora, Colo. 80045.
BACKGROUND--Serum angiotensin-converting enzyme (ACE) level is elevated in a number of disease states and medical conditions. Based on review of the medical literature, we postulated that serum ACE level elevation may occur during infection with the human immunodeficiency virus (HIV). METHODS--In a prospective, contro
Cancer. 1992 Mar 1;69(5):1208-11. Unique Identifier : AIDSLINE MED/92154568
Chetsanga C; Malmstrom PU; Gyllensten U; Moreno-Lopez J; Dinter Z; Pettersson U; Department of Medical Genetics, University of Uppsala, Sweden.
Human papillomavirus (HPV) detection was done using the polymerase chain reaction technique on tumor tissue from 44 patients with transitional cell carcinoma of the urinary bladder. Only one of the 44 was associated with HPV infection. The HPV-positive patient was not known to have immunodeficiency or genital warts, a
Gaulton GN; Brass LF; Kozbor D; Pletcher CH; Hoxie JA; Department of Pathology, University of Pennsylvania, School of; Medicine, Philadelphia, Pennsylvania 19104.
Inhibitory effects of human immunodeficiency virus (HIV) on T lymphocyte function have been linked to perturbation of signaling through the T cell antigen receptor-CD3 complex. Comparative biochemical analyses of signaling responses were performed in T cells that were either uninfected or chronically infected with the
Shiramizu B; Herndier B; Meeker T; Kaplan L; McGrath M; Department of Pediatrics, University of California, San Francisco; 94110.
PURPOSE: A molecular analysis of non-Hodgkin s lymphomas (NHLs) from patients with AIDS was undertaken to determine the prevalence and immunophenotype of polyclonal B-cell lymphoma. MATERIALS AND METHODS: DNA was extracted from 40 diagnostic biopsy specimens obtained from patients seen at University of California, San
JAMA. 1992 Mar 11;267(10):1368-71. Unique Identifier : AIDSLINE MED/92157288
Daniels N; Philosophy Department, Tufts University, Medford, Mass 02168.
The ethical issues surrounding the Centers for Disease Control and American Medical Association guidelines for health professionals infected with the human immunodeficiency virus are examined and discussed. Although human immunodeficiency virus transmission risks during surgery a
In order to determine the sensitivity of herpes simplex virus (HSV) isolates from immunocompromised patients treated with antiviral compounds, a retrospective study was carried out in the Clinical Virology Department of the University Medical Centre, Amsterdam. Virus isolates from four AIDS patients and one bone marro
Lin DS; Bowman DD; Jacobson RH; Department of Microbiology, Immunology, and Parasitology, College; of Veterinary Medicine, Cornell University, Ithaca, New York; 14853-6401.
To examine the immunological changes in cats concurrently infected with feline immunodeficiency virus (FIV) and Toxoplasma gondii, kittens (four per group) were inoculated with FIV, T. gondii, both agents, or no pathogens. Blood mononuclear cells and plasma were collected weekly for lymphocyte assays and serology. At
Lancet. 1992 Feb 8;339(8789):333-4. Unique Identifier : AIDSLINE MED/92130621
Jacobson MA; Besch CL; Child C; Hafner R; Matts JP; Muth K; Wentworth DN; Deyton L; Department of Medicine, University of California, San Francisco.
A double-blind, placebo-controlled trial was set up to compare clindamycin and pyrimethamine as prophylaxis for toxoplasmic encephalitis (TE) in HIV-infected patients at risk of the disorder. Interim analysis showed that clindamycin-treated patients were 4.4 (95% confidence interval 1.3-15.2) times more likely to expe
BMJ. 1992 Jan 4;304(6818):13-7. Unique Identifier : AIDSLINE MED/92136005
OBJECTIVE--To compare the efficacy and side effects of 400 mg, 800 mg, and 1200 mg zidovudine daily in patients with AIDS or advanced HIV infection. DESIGN--Randomised, double blind, parallel group multicentre study. SETTING--Hospital departments of infectious diseases and dermatology in
N Engl J Med. 1992 Mar 5;326(10):668-72. Unique Identifier : AIDSLINE MED/92140463
Berenguer J; Moreno S; Laguna F; Vicente T; Adrados M; Ortega A; Gonzalez-LaHoz J; Bouza E; Department of Clinical Microbiology and Infectious Diseases,; Hospital General Gregorio Maranon, Madrid, Spain.
BACKGROUND AND METHODS. Tuberculosis is a frequent complication of human immunodeficiency virus (HIV) infection. We describe the clinical manifestations and outcomes of tuberculous meningitis in patients with HIV infection, and compare them with those in non-HIV-infected patients. We reviewed the records from 1985 thr
Am J Epidemiol. 1992 Jan 1;135(1):1-11. Unique Identifier : AIDSLINE MED/92143125
Seage GR 3d; Mayer KH; Horsburgh CR Jr; Holmberg SD; Moon MW; Lamb GA; Institute for Urban Health Policy, Research, and Education,; Boston Department of Health and Hospitals, MA.
The role of nitrite was evaluated between 1985 and 1988 in a study of sexual transmission of the human immunodeficiency virus (HIV) among homosexual male couples in Boston, Massachusetts. Initial enrollment data suggested that a history of unprotected receptive anal intercourse (odds ratio (OR) = 2.3, 95% confidence i
AIDS Res Hum Retroviruses. 1992 Jan;8(1):19-26. Unique Identifier : AIDSLINE MED/92144205
McClure MO; Moore JP; Blanc DF; Scotting P; Cook GM; Keynes RJ; Weber JN; Davies D; Weiss RA; Chester Beatty Laboratories, Institute of Cancer Research,; London, England.
Sulfated polysaccharides have been shown to inhibit human immunodeficiency virus (HIV) infection in vitro. Dextrin sulfate, fucoidan, and dextran sulfate fail to neutralize virions directly, but interact with target cells to inhibit virus entry. Ionic interactions of sulfated polyanions with oppositely charged cell su
AIDS Res Hum Retroviruses. 1992 Jan;8(1):69-75. Unique Identifier : AIDSLINE MED/92144211
Eibl MM; Kupcu Z; Mannhalter JW; Eder G; Schaff Z; Institute of Immunology, University of Vienna, Austria.
In humans, macrophages serve as a major reservoir of human immunodeficiency virus (HIV-1) in the infected host and may play a role in the pathogenesis of the disease. In HIV-1-infected chimpanzees, however, virus could not be recovered from cells of the monocyte/macrophage lineage, leaving the question of macrophage t
Kieburtz KD; Seidlin M; Lambert JS; Dolin R; Reichman R; Valentine F; Department of Neurology, University of Rochester School of; Medicine, New York.
Neuropathic complaints were frequently observed in a Phase I study of dideoxyinosine (ddI) in 44 patients with AIDS and AIDS-related complex. Ten patients (23%) were thought to have a ddI-related peripheral neuropathy . The symptoms were primarily sensory, and there wa
Nelson GW; Perelson AS; Los Alamos National Laboratory, NM 87545.
Strains of human immunodeficiency virus (HIV) differ greatly in their ability to replicate in T4 cells. Fast-replicating strains are observed during the early and late stages of HIV infection, while slow-replicating strains prevail during the intermediate, latent, stage. The prevalence of slow-replicating strains has
BMJ. 1992 Jan 25;304(6821):212-6. Unique Identifier : AIDSLINE MED/92154239
Aledort LM; Hilgartner MW; Pike MC; Gjerset GF; Koerper MA; Lian EY; Lusher JM; Mosley JW; Transfusion Safety Study, Los Angeles, California 90032.
OBJECTIVE--To examine the CD4 count and its near term changes relative to progression to AIDS within 30 months and to subsequent CD4 counts. DESIGN--Longitudinal clinical and laboratory study. SETTING--Haemophilia treatment centres in six large American cities. PATIENTS--555 people with congenital clotting disorders w
Chehimi J; Starr SE; Frank I; Rengaraju M; Jackson SJ; Llanes C; Kobayashi M; Perussia B; Young D; Nickbarg E; et al; Division of Infectious Diseases and Immunology, Children's; Hospital of Philadelphia, Pennsylvania.
Natural killer cell stimulatory factor (NKSF), or interleukin 12 (IL-12), is a heterodimeric lymphokine produced by B cells that has multiple effects on T and NK cell functions. NKSF at concentrations as low as 0.4 pM enhances the spontaneous cytotoxic activity of peripheral blood lymphocytes (PBL) against a variety o
Bass HZ; Hardy WD; Mitsuyasu RT; Taylor JM; Wang YX; Fischl MA; Spector SA; Richman DD; Fahey JL; Center for Interdisciplinary Research in Immunology and Disease,; Department of Medicine, University of California, Los Angeles.
Sixty-one subjects with mildly symptomatic human immunodeficiency virus (HIV) infection were included in a double-blind, randomized, placebo-controlled trial of zidovudine (part of AIDS Clinical Trials Group protocol 016, ACTG 016) to evaluate changes in the serum immune activation markers neopterin and beta 2-microgl
Lancet. 1992 Feb 29;339(8792):515-8. Unique Identifier : AIDSLINE MED/92157759
Huang YQ; Li JJ; Rush MG; Poiesz BJ; Nicolaides A; Jacobson M; Zhang WG; Coutavas E; Abbott MA; Friedman-Kien AE; Department of Microbiology, New York University School of; Medicine, New York.
In the USA, Kaposi s sarcoma associated with the acquired immunodeficiency syndrome (AIDS-KS) is ten times more common in homosexual or bisexual men than in heterosexual men with AIDS. One explanation for this finding is that AIDS-KS may be caused by an infectious agent. Because there is a high incidence of human papi
Am J Psychiatry. 1992 Mar;149(3):367-70. Unique Identifier : AIDSLINE MED/92160974
Gorman JM; Warne PA; Begg MD; Cooper TB; Novacenko H; Williams JB; Rabkin J; Stern Y; Ehrhardt AA; HIV Center for Clinical and Behavioral Studies, New York State; Psychiatric Institute, NY 10032.
OBJECTIVE: Prolactin is a neurohormone that may be secreted in response to stress and also has regulatory effects on the immune system. Some, but not all, studies suggest that prolactin levels are higher than normal in persons with HIV infection. The authors measured prolactin levels in HIV-positive and HIV-negative h
Bell SJ; Cooper DA; Kemp BE; Doherty RR; Penny R; Centre for Immunology, St. Vincent's Hospital, Sydney, Australia.
The majority of the immunodominant amino acid sequences of HIV-1 that have been characterized to date are coded for by hypervariable gene sequences. These variable sequences are however interspersed with sequences that are highly conserved between HIV strains. Immunogenic viral products with amino acid sequences that
Huang P; Farquhar D; Plunkett W; Department of Medical Oncology, University of Texas M.D. Anderson; Cancer Center, Houston 77030.
This study used DNA primer extension and sequencing gel analyses to evaluate the molecular action of 2 ,3 -didehydro-2 ,3 -dideoxythymidine triphosphate (D4TTP), in comparison with 3 -azido-2 ,3 -dideoxythymidine triphosphate (AZTTP), on DNA strand elongation by human immunodeficiency virus reverse transcriptases (HIV
Warren RQ; Nkya WM; Shao JF; Anderson SA; Wolf H; Hendrix CW; Kanda P; Wabuke M; Boswell RN; Redfield RR; et al; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, Texas 78284.
In this study, we compared sera from 159 human immunodeficiency virus type 1 (HIV-1)-infected individuals from Tanzania and 103 infected individuals from the United States for antibodies reactive with 10 HIV-1 gp160 epitopes defined by synthetic p
Sherman MP; Ehrlich GD; Ferrer JF; Sninsky JJ; Zandomeni R; Dock NL; Poiesz B; Department of Medicine, State University of New York Health; Science Center, Syracuse 13210.
Bovine leukemia virus (BLV) is the etiologic agent of leukemia in cattle and is believed to cause decreases in milk productivity, fertility, and life span in infected cows. BLV is a type C retrovirus in the Oncovirinae subfamily. It is most closely related to human T-cell lymphoma/leukemia virus type I (HTLV-I) and ty
Biochemistry. 1992 Feb 4;31(4):954-8. Unique Identifier : AIDSLINE MED/92135214
Ji JP; Loeb LA; Joseph Gottstein Memorial Cancer Research Laboratory, Department; of Pathology, University of Washington, Seattle 98195.
The genomic hypervariation of human immunodeficiency virus 1 (HIV-1) could result from misincorporations by the viral reverse transcriptase. We developed an assay for reverse transcriptase fidelity during RNA-dependent as well as DNA-dependent DNA polymerization in vitro. A lacZ alpha RNA fragment transcribed by T3 RN
Lal RB; Rudolph DL; Schmid DS; Lairmore MD; Retrovirus Diseases Branch, Centers for Disease Control, Atlanta,; GA 30333.
To examine the immunomodulatory effects of HTLV infection, lymphocyte subset analysis was performed on patients infected with human T cell lymphotropic virus type-I (HTLV-I, n = 6) or II (HTLV-II, n = 12) and on normal blood donors (n = 16). The percentages of total B lymphocytes (CD19), natural killer (NK) cells (CD1
Miller TL; Winter HS; Luginbuhl LM; Orav EJ; McIntosh K; Combined Program in Pediatric Gastroenterology and Nutrition,; Children's Hospital, Boston, MA 02115.
Because pancreatitis has been reported frequently in adults with human immunodeficiency virus infection, we sought to determine the incidence of pancreatitis in children with acquired immunodeficiency syndrome by reviewing all records of children with AIDS, their serum amylase and lipase levels, and the factors associ
Proc Natl Acad Sci U S A. 1992 Feb 1;89(3):927-31. Unique Identifier : AIDSLINE MED/92141231
Ben-Artzi H; Zeelon E; Gorecki M; Panet A; BioTechnology General Ltd., Kiryat Weizmann, Rehovot, Israel.
Early events in the retroviral replication cycle include the conversion of viral genomic RNA into linear double-stranded DNA. This process is mediated by the reverse transcriptase (RT), a multifunctional enzyme that possesses RNA-dependent DNA polymerase, DNA-dependent DNA polymerase, and RNase H activities. In the co
Tahtinen M; Gombert F; Hyytinen ER; Jung G; Ranki A; Krohn KJ; University of Tampere, Institute of Biomedical Sciences, Finland.
We have previously used partially overlapping synthetic nonapeptides to characterize the human natural antibody response against HIV-1 negative regulatory factor (NEF), and identified nine 5 to 13 amino acid long regions that were recognized by sera of HIV-1-infected individuals. In this report we define the minimal s
Yao XJ; Wainberg MA; Parniak MA; Lady Davis Institute for Medical Research, Sir Mortimer B.; Davis-Jewish General Hospital, Montreal, Quebec, Canada.
Crude extracts of four Chinese herbs, Arctium lappa, Astragalus membranaceus, Andrographis paniculata, and Prunella vulgaris, were assessed in several tissue culture lines for anti-HIV activity and for cytotoxicity. One extract, obtained from P. vulgaris, was able to significantly inhibit HIV-1 replication with relati
Vlach J; Pitha PM; Oncology Center, Johns Hopkins University School of Medicine,; Baltimore, Maryland 21231.
We have analyzed the limiting factors involved in the induction of human immunodeficiency virus type 1 (HIV-1) provirus expression by tumor necrosis factor-alpha (TNF-alpha), phorbol-12-myristate-13-acetate (PMA), and bryostatin-1 in T-cells (ACH-2) and monocytes (U1). We have demonstrated that, while there is a corre
Am J Med. 1992 Feb 14;92(2A):3S-7S. Unique Identifier : AIDSLINE MED/92143169
Crumpacker CS; Department of Infectious Diseases, Beth Israel Hospital, Boston,; Massachusetts 02215.
Foscarnet is a pyrophosphate analogue with activity against herpesviruses, human immunodeficiency virus (HIV), and other RNA and DNA viruses. Foscarnet and its analogues achieve their antiviral effects via inhibition of viral polymerases, with such inhibition not being dependent on activation or phosphorylation of the
Am J Med. 1992 Feb 14;92(2A):8S-11S. Unique Identifier : AIDSLINE MED/92143171
Lietman PS; Division of Clinical Pharmacology, Johns Hopkins University; School of Medicine, Baltimore, Maryland.
Foscarnet exerts its antiviral effects via reversible inhibition of viral polymerases. Pharmacodynamic data indicate that herpesvirus and human immunodeficiency virus replication is inhibited by therapeutically achievable concentrations of foscarnet; however, the concentrations of foscarnet required for such inhibitio
Ann Allergy. 1992 Jan;68(1):58-63. Unique Identifier : AIDSLINE MED/92143334
Silvers WS; University of Colorado Health Sciences Center, Denver.
Exercise is a physical cause of allergic reactions, including exercise-induced anaphylaxis (EIAna), exercise-induced urticaria (EIU), exercise-induced asthma (EIA), and exercise-induced rhinitis (EIR). Since its first description in 1979, EIAna has been reported with variable clinical manifestations, with exercise alo
AIDS Res Hum Retroviruses. 1992 Jan;8(1):47-52. Unique Identifier : AIDSLINE MED/92144208
Henrard DR; Mehaffey WF; Allain JP; Abbott Laboratories, Abbott Park, IL 60064.
Human immunodeficiency virus was detected in the serum/plasma of individuals infected with human immunodeficiency virus (HIV) after capture of virions on microparticles coated with monoclonal antibodies to external and transmembrane proteins of HIV-1. We analyzed serial samples obtained from 6 individuals who seroconv
Biochemistry. 1992 Feb 11;31(5):1375-9. Unique Identifier : AIDSLINE MED/92144541
Ma QF; Bathurst IC; Barr PJ; Kenyon GL; Department of Pharmaceutical Chemistry, University of California,; San Francisco 94143.
The inhibitory potency of 3 -azido-3 -deoxythymidine 5 -triphosphate (AZTTP) against HIV-1 reverse transcriptase (HIV-1 RT) has been further evaluated. The results indicate that the previously reported low Ki values for AZTTP against HIV-1 RT (2.35 nM) are due neither to the to the direct tight binding of AZTTP to HIV
Mbemba E; Chams V; Gluckman JC; Klatzmann D; Gattegno L; Laboratoire de Biologie Cellulaire, Faculte de Medecine,; Bobigny, France.
We investigated at the molecular level the interaction between, HIV-1 recombinant gp160 (rgp160) and low-molecular-weight dextran sulfate. We demonstrate the occurrence of a specific interaction between rgp160 and sulfated dextran beads, which is saturable, pH-dependent and inhibitable by soluble dextran sulfate but n
J Immunol. 1992 Feb 15;148(4):1222-9. Unique Identifier : AIDSLINE MED/92148145
D'Addario M; Wainberg MA; Hiscott J; Lady Davis Institute, Sir Mortimer B Davis-Jewish General; Hospital, Montreal, Quebec, Canada.
The differential production of inflammatory cytokines (IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha) was analyzed in the PLB-985 myelomonoblastic cell line, chronically infected or not by the IIIB strain of HIV-1. After treatment with phorbol ester (PMA) or TNF-alpha, a 20- to 40-fold increase in the level of IL-1 beta
Muller F; Holberg-Petersen M; Rollag H; Degre M; Brandtzaeg P; Froland SS; Kaptein W. Wilhelmsen og frues Institute of Bacteriology,; University of Oslo, National Hospital, Rikshospitalet, Norway.
Lactoferrin, lysozyme, interferon, and neopterin levels were determined in parotid saliva from 44 individuals with different clinical stages of human immunodeficiency virus (HIV) infection and 19 HIV-seronegative controls. The secretory output of individual components was calculated according to the fluid flow rate. N
Tchenio T; Heidmann T; Unites de Biochimie-Enzymologie et de Physicochimie; Macromoleculaire, Centre National de la Recherche Scientifique; U147, Villejuif, France.
We devised an indicator gene for retrotransposition, nlsLacZRT, which contains the Escherichia coli lacZ gene fused to a nuclear location signal (nlsLacZ), engineered in such a way that the gene is expressed only if the structure in which it has been inserted transposes itself through an RNA intermediate. A cloned mur
Lerch RA; Friesen PD; Institute for Molecular Virology, Graduate School, University of; Wisconsin-Madison 53706-1596.
TED is a lepidopteran retrotransposon found inserted within the DNA genome of the Autographa californica nuclear polyhedrosis virus mutant, FP-D. To examine the proteins and functions encoded by this representative of the gypsy family of retrotransposons, the gag- and pol-like open reading frames (ORFs 1 and 2) were e
Zack JA; Haislip AM; Krogstad P; Chen IS; Department of Medicine, University of California, Los Angeles; School of Medicine.
Using a quantitative polymerase chain reaction (PCR) method, we have previously shown that a molecularly cloned isolate of human immunodeficiency virus type 1 (HIV-1) can efficiently enter quiescent primary lymphocytes; however, the reverse transcription process is not completed in these cells. In this study, we furth
Alexander JW; Babcock GF; First MR; Davies CB; Madden RL; Munda R; Penn I; Fidler JP; Cofer BR; Stephens G; et al; Department of Surgery, University of Cincinnati College of; Medicine, Ohio 45267-0558.
A prospective randomized preliminary trial was performed in patients undergoing cadaveric renal transplantation to determine the potential benefits, disadvantages, and logistic problems associated with the administration of donor-specific transfusions and cyclosporine initiated 24 hr before transplantation. Ten patien
Bebenek K; Roberts JD; Kunkel TA; Laboratory of Molecular Genetics, National Institute of; Environmental Health Sciences, Research Triangle Park, North; Carolina 27709.
The use of unequal concentrations of the four deoxynucleoside triphosphates (dNTPs) in DNA polymerization reactions alters base substitution error rates in a predictable way. Less is known about the effects of substrate imbalances on base addition and deletion error rates. Thus, we examined pool bias effects on frames
Shaharabany M; Hizi A; Department of Cell Biology and Histology, Sackler School of; Medicine, Tel Aviv University, Israel.
The reverse transcriptases (RTs) from human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2, respectively) are relatively highly related yet there are several significant differences in their catalytic activities. In an attempt to relate these functional dissimilarities to the differences in amino acid sequenc
Orr DC; Figueiredo HT; Mo CL; Penn CR; Cameron JM; Department of Virology, Glaxo Group Research Ltd., Greenford,; United Kingdom.
Carbocyclic 2 ,3 -didehydro-2 ,3 -dideoxyguanosine (carbovir, NSC 614846) is an anti-retroviral agent that may be useful in the treatment of AIDS. We have examined the ability of (-)-enantiomeric carbovir triphosphate to inhibit human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (EC 2.7.7.49). A compari
Blomberg J; Robert-Guroff M; Blattner WA; Pipkorn R; Department of Medical Microbiology, University of Lund, Sweden.
The human T lymphotropic viruses (HTLV-I and -II) are relatively common in subpopulations of certain countries, notably intravenous drug abusers in North America. Infections with these malignancy-associated human retroviruses are hard to discriminate with currently available commercial serological tests. We studied th
Lancet. 1992 Feb 22;339(8791):453-6. Unique Identifier : AIDSLINE MED/92157699
Mildvan D; Machado SG; Wilets I; Grossberg SE; Division of Infectious Diseases, Beth Israel Medical Center, New; York, New York 10003.
To improve evaluation of new antiretroviral drugs in the acquired immunodeficiency syndrome (AIDS), sensitive biological markers that accurately predict response to treatment are needed. Two possible markers are endogenous interferon (E-IFN), which is a cytokine involved in the pathophysiology of AIDS, and serum trigl
Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1418-22. Unique Identifier : AIDSLINE MED/92159060
Javaherian K; Langlois AJ; Schmidt S; Kaufmann M; Cates N; Langedijk JP; Meloen RH; Desrosiers RC; Burns DP; Bolognesi DP; et al; Repligen Corporation, Cambridge, MA 02139.
To identify the principal neutralization determinant (PND) of simian immunodeficiency virus (SIV), antisera were generated using recombinant gp110 [the SIV analog of the human immunodeficiency virus type 1 (HIV-1) external envelope glycoprotein, gp120], gp140, several large recombinant and proteolytic envelope fragmen
Loya S; Kashman Y; Hizi A; Department of Cell Biology and Histology, Sackler School of; Medicine, Tel Aviv University, Israel.
We have studied the effects of a natural carotenoid, identified as halocynthiaxanthin, on the enzymatic activities associated with the recombinant preparations of the reverse transcriptases (RTs) of human immunodeficiency viruses (HIV) types 1 and 2. The carotenoid was found to be a potent inhibitor of the RNA-depende
Rosner, Richard; Weinstock, Robert, eds. Ethical Practice in Psychiatry and the Law. New York: Plenum Press, 1990 :219-242. Unique Identifier : AIDSLINE KIE/34497
Hanna, Kathi E., ed.; Institute of Medicine. Committee to Study Biomedical Decision Making. Biomedical Politics. Washington: National Academy Press, 1991 :9-42. Unique Identifier : AIDSLINE KIE/34531
Beck, James C., ed. Confidentiality Versus the Duty to Protect: Foreseeable Harm in the Practice of Psychiatry. Washington: American Psychiatric Press, 1990 :121-140. Unique Identifier : AIDSLINE KIE/34552
California Reporter. 1991 Jan 14 (date of decision);277:354-363. Unique Identifier : AIDSLINE KIE/34650
The California Court of Appeal held that there was a right to privacy under the California Constitution for an employee whose HIV status was disclosed by a physician retained by his employer s insurance company in a worker s compensation case. The employee had disclosed his positive HIV status to the physician s nurse
Rosner, Richard; Weinstock, Robert, eds. Ethical Practice in Psychiatry and the Law. New York: Plenum Press, 1990 :243-255. Unique Identifier : AIDSLINE KIE/34498
Faden, Ruth; Geller, Gail; Powers, Madison, eds. AIDS, Women and the Next Generation. New York: Oxford University Press, 1991 :201-220. Unique Identifier : AIDSLINE KIE/34543
Faden, Ruth; Geller, Gail; Powers, Madison, eds. AIDS, Women and the Next Generation. New York: Oxford University Press, 1991 :221-255. Unique Identifier : AIDSLINE KIE/34544
Faden, Ruth; Geller, Gail; Powers, Madison, eds. AIDS, Women and the Next Generation. New York: Oxford University Press, 1991 :274-287. Unique Identifier : AIDSLINE KIE/34546
Faden, Ruth; Geller, Gail; Powers, Madison, eds. AIDS, Women and the Next Generation. New York: Oxford University Press, 1991 :288-307. Unique Identifier : AIDSLINE KIE/34547
Faden, Ruth; Geller, Gail; Powers, Madison, eds. AIDS, Women and the Next Generation. New York: Oxford University Press, 1991 :308-327. Unique Identifier : AIDSLINE KIE/34548
Faden, Ruth; Geller, Gail; Powers, Madison, eds. AIDS, Women and the Next Generation. New York: Oxford University Press, 1991 :331-358. Unique Identifier : AIDSLINE KIE/34549
Faden RR; Geller G; Powers M; Acuff K; Allen A; Areen J; Hutton N; Johnson T; Kass N; King P; et al
The Hawaii Supreme Court held that a dental patient was not discriminated against when the Kahala Dental Group refused to perform procedures involving blood because the patient refused to provide the Group with medical information as to his HIV status. The court held that the dental services were denied not because of
Faden, Ruth; Geller, Gail; Powers, Madison, eds. AIDS, Women and the Next Generation. New York: Oxford University Press, 1991 :3-26. Unique Identifier : AIDSLINE KIE/34539
Faden, Ruth; Geller, Gail; Powers, Madison, eds. AIDS, Women and the Next Generation. New York: Oxford University Press, 1991 :59-93. Unique Identifier : AIDSLINE KIE/34540
Faden, Ruth; Geller, Gail; Powers, Madison, eds. AIDS, Women and the Next Generation. New York: Oxford University Press, 1991 :121-165. Unique Identifier : AIDSLINE KIE/34541
Faden, Ruth; Geller, Gail; Powers, Madison, eds. AIDS, Women, and the Next Generation. New York: Oxford University Press, 1991 :166-200. Unique Identifier : AIDSLINE KIE/34542
Faden, Ruth; Geller, Gail; Powers, Madison, eds. AIDS, Women and the Next Generation. New York: Oxford University Press, 1991 :259-273. Unique Identifier : AIDSLINE KIE/34545
This information is designed to support, not replace, the relationship that exists between you and your doctor.