1994

Managing early HIV infection : AHCPR clinical practice guideline. [videorecording]: Secaucus, N.J. : Network for Continuing Medical Education, 1994 1 videocassette (30 min.) : sd., col. ; 1/2 in. + 1 booklet (NCME telecourse ; no. 666) Unique Identifier : AIDSLINE AV/9441209; Oleske JM; A co-chair of the panel that developed the AHCPR HIV guideline discusses selected elements of adult and pediatric care. Topics include disclosure of HIV status, CD4 lymphocyte counts, prevention and treatment of opportunistic infections, antiretroviral therapy, and systems for case management.
[Bibliografia sobre los aspectos epidemiologicos, sociales, legales y eticos del SIDA.]: Rio Piedras, P.R. : Institute of Caribbean Studies, c1990 v, 338 p (Serie bibliografica ; num. 1 = Bibliographical series ; no. 1) Unique Identifier : AIDSLINE CAT/9413402; Cunningham I
[Igrejas e AIDS.]: Rio de Janeiro : ISER, 1990- v. ill Unique Identifier : AIDSLINE CAT/9407460
[Als je het nou van hard werken kreeg: : tien jaar AIDS en homocultuur.]: [Netherlands] : Veen, c1991 158 p. : ill (Homostudies Utrecht) Unique Identifier : AIDSLINE CAT/9403732; Kerkhof Mv
[AIDS e enfermagem obstetrica.]: Sao Paulo, Brasil : E.P.U., c1991 vii, 61 p. : ill Unique Identifier : AIDSLINE CAT/9408141; Marin Hd
[Le:depistage de l'infection par le VIH.]: [Paris : Le Haut Comite], c1992 iii, 45 p (Collection Avis et rapports du HCSP) Unique Identifier : AIDSLINE CAT/9415265
[AIDS und niedergelassene Arzte/Arztinnen in Wien : eine empirische Untersuchung zur ambulanten Versorgung von HIV-positiven und AIDSkranken Patient/innen.]: Wien : Institut fur Soziologie, Universitat Wien, Grund- und Integrativwissenschaftliche Fakultat, 1992 57 p (Schriftenreihe des Instituts fur Soziologie, Universitat Wien, Grund- und Integrativwissenschaftliche Fakultat ; 27) Unique Identifier : AIDSLINE CAT/9420416; Edlinger J
[Un:sang impur : l'affaire des hemophiles contamines.]: [S.l.] : J.C. Lattes, c1992 211 p Unique Identifier : AIDSLINE CAT/9412310; Paugam S
[Partikulare Arzneistofftrager als System fur Drug-Targeting : zur Therapie der HIV-Infektion und AIDS.]: Frankfurt/Main : VAS, c1993 155 p. : ill Unique Identifier : AIDSLINE CAT/9420513; Schafer V
AIDS and the heterosexual population.: Switzerland ; USA : Harwood Academic, c1993 xix, 281 p. : ill Unique Identifier : AIDSLINE CAT/9432615; Sherr L
The:Changing face of AIDS : implications for social work practice.: Westport, Conn. : Auburn House, 1993 xxix, 251 p. : ill Unique Identifier : AIDSLINE CAT/9431245; Lynch VJ; Lloyd GA; Fimbres M
[Migrants et perception du Sida : Le Maitre des infideles.]: Paris : L'Harmattan, c1993 143 p (Sante, societes et cultures) Unique Identifier : AIDSLINE CAT/9418253; Moumen-Marcoux R
[Netzwerk AIDS : 10 Jahre AIDS-Hilfe und ihre psychosozialen Angebote.]: Berlin : Deutsche AIDS-Hilfe, [1993] 175 p. : ill., ports Unique Identifier : AIDSLINE CAT/9423000; Biniasz T
Could it be HIV? : the clinical recognition of HIV infection.: Kingsgrove, NSW : Australasian Medical Pub. Co., 1993 76 p. : ill Unique Identifier : AIDSLINE CAT/9422520; Stewart G
[Dokumentation AIDS im Strafvollzug : Ergebnisse der Befragung von Menschen mit HIV/AIDS in bundesdeutschen Strafvollzugsanstalten.] 1. Aufl.: Berlin : Deutsche AIDS-Hilfe, [1993] 80 p. : port (AIDS Info) Unique Identifier : AIDSLINE CAT/9422739; Gahner M
HIV prevention.: Austin, TX : The Bureau, v Unique Identifier : AIDSLINE CAT/9432578
[Rechtliche Bedeutung des Status HIV-positiv : Leitfaden fur Sozialversicherungsrecht, Privatversicherungsrecht, Arbeitsrecht und Strafrecht.]: Basel : Verlag Helbing & Lichtenhahn, c1993 98 p Unique Identifier : AIDSLINE CAT/9420539; Keller M
AIDS : crisis in professional ethics.: Philadelphia : Temple University Press, 1994 vi, 276 p Unique Identifier : AIDSLINE CAT/9433456; Cohen ED; Davis M
AIDS, ethics & religion : embracing a world of suffering.: Maryknoll, N.Y. : Orbis Books, c1994 ix, 284 p Unique Identifier : AIDSLINE CAT/9433075; Overberg KR
HIV, perinatal infections, and therapy : the role of the placenta.: Rochester, N.Y. : University of Rochester Press, 1994 xvii, 614 p. : ill., port (Trophoblast research ; v. 8) Unique Identifier : AIDSLINE CAT/9441204; Miller RK; Thiede HA
H-2K(b) gene and retrovirus interactions in the regulation of BL6 melanoma cell sensitivity to tumor necrosis factor-alpha.: Diss Abstr Int [B]; 54(6):2980 1993. Unique Identifier : AIDSLINE ICDB/94605777; Kim M; Univ. of Pittsburgh; The effect of major histocompatibility complex (MHC) class I gene expression on the sensitivity of BL6 melanoma cells to the cytotoxic effects of TNF-alpha was studied. Experiments were performed using B16F10BL6 melanoma line (hereafter referred as BL6) that is a highly invasive and metastatic cell line. BL6 melanoma
Adoptive immunotherapy of cancer: a new approach for cancer treatment.: Diss Abstr Int [B]; 54(6):2983 1993. Unique Identifier : AIDSLINE ICDB/94605782; Qin YC; Limburgs Universitair Centrum, Belgium; The conventional treatments of cancer are surgery, chemotherapy and radiotherapy. However, the therapeutic efficacy of these treatments are still far from satisfactory in most cases. With the development of immunology and increasing understanding in tumor immunology, immunotherapy has moved onto the stage of cancer tr
The endothelium in HIV-associated Kaposi's sarcoma.: Diss Abstr Int [B]; 54(6):3004 1993. Unique Identifier : AIDSLINE ICDB/94605793; Corbeil J; Univ. of New South Wales, Australia; The aim of this project was to culture Kaposi s sarcoma-derived (KS) cells in order to investigate its etiology and attempt to elucidate the role of the vascular endothelial cell (EC) in this pathological process. The establishment of five cell cultures derived from pleural or peritoneal fluid of HIV-infected individu
Interleukin-6 and the lung.: Lung Biol Health Dis; 61:229-80 1993. Unique Identifier : AIDSLINE ICDB/94606665; Zitnik RJ; Elias JA; Dept. of Internal Medicine, Yale Univ. Sch. of Medicine, New; Haven, CT; Interleukin-6 (IL6) is a pleiotropic cytokine produced by a wide variety of cells, including many of the major cells in the lung, and in response to a broad spectrum of stimuli (eg, viral infection, bacterial endotoxin, agonists of cAMP, PKC, and calcium 2nd-messenger systems). Regulation of IL6 production is complex
Retroviruses in human cancer (Meeting abstract).: EACR-12: 12th Biennial Meeting of the European Association for Cancer Research. April 4-7, 1993, Brussels, Belgium, 1993.. Unique Identifier : AIDSLINE ICDB/94697506; Weiss RA; Chester Beatty Laboratories, Inst. of Cancer Res., 237 Fulham; Rd., London SW3 6JB, UK; The retroviruses linked with human cancer fall into two distinct categories. Human T-cell leukemia viruses (HTLV-I, HTLV-II) are oncoviruses. HTLV-I infection accounts for the major burden of adult T-cell lymphoma and leukemia in regions such as Japan , the Caribbean basin and some W
Subtypes of Epstein-Barr virus in HIV-1-positive and HIV-1-negative patients with Hodgkin's disease (Meeting abstract).: EACR-12: 12th Biennial Meeting of the European Association for Cancer Research. April 4-7, 1993, Brussels, Belgium, 1993.. Unique Identifier : AIDSLINE ICDB/94697510; De Re V; De Vita S; Marzotto A; Gloghini A; Carbone A; Uccini S; Scarpa A; and Boiocchi M; Div. of Experimental Oncology, Aviano, Italy; Considerable evidence suggests that EBV has a role in the pathogenesis of Hodgkin s disease (HD). In immunocompetent hosts type 2 EBV is considered to be a much less potent transformer of lymphocytes than type 1 virus strain. However, type 2 EBV may be involved in the pathogenesis of non-Hodgkin s lymphomas arising in
Bispecific antibodies recruiting cellular effectors (Meeting abstract).: EACR-12: 12th Biennial Meeting of the European Association for Cancer Research. April 4-7, 1993, Brussels, Belgium, 1993.. Unique Identifier : AIDSLINE ICDB/94697527; Thielemans K; Lab. of Physiology-Immunology, Vrije Universiteit Brussel, B-1090; Brussels, Belgium; The idea to target T lymphocytes toward tumor cells has been tested extensively and successfully by many laboratories. Our laboratory has evaluated this attractive approach in vivo. We have developed bispecific antibodies by hybrid-hybridoma technique, with dual specificity: the murine CD3 complex and the idiotype (tu
Reconstitution of viral immunity by the adoptive transfer of T-cell clones modified by gene insertion (Meeting abstract).: EACR-12: 12th Biennial Meeting of the European Association for Cancer Research. April 4-7, 1993, Brussels, Belgium, 1993.. Unique Identifier : AIDSLINE ICDB/94697579; Greenberg P; Watanabe K; Gilbert M; Nelson B; Riddell S; Univ. of Washington, Seattle, WA 98195; The essential role of CD8+ Tc for protection from CMV disease is supported by studies in which we demonstrated that patients who endogenously reconstitute their CMV-specific CD8+ Tc response are protected from the development of CMV disease, whereas patients lac
Molecular Biology of Hematopoiesis, 8th Symposium. July 9-13, 1993, Basel, Switzerland.: Molecular Biology of Hematopoiesis, 8th Symposium. July 9-13, 1993, Basel, Switzerland, 222 p., 1993.. Unique Identifier : AIDSLINE ICDB/94699269; Anonymous; No affiliation given; The 8th symposium on Molecular Biology of Hematopoiesis, held July 9-13, 1993, in Basel, Switzerland , addressed these topics: bone marrow transplantation, immune stimulation and suppression, development of T and B cells, viruses and cytokines, HIV and other viruses, gene regul
Genetically modified T-cell clones as a treatment for human viral diseases (Meeting abstract).: SBT93: Society for Biological Therapy, 8th Annual Scientific Meeting: Biological Therapy of Cancer--VIII. November 10-14, 1993, Nashville, TN, p. 50, 1993.. Unique Identifier : AIDSLINE ICDB/94699586; Riddell SR; Overell RW; Lupton S; Greenberg PD; Fred Hutchinson Cancer Res. Center, 1124 Columbia St., Seattle,; WA 98104; The adoptive transfer of MHC restricted antigen-specific T cells is an effective therapy for viral diseases and malignancies in animal models. Recent advances in the in vitro isolation and expansion of human antigen-specific T cell clones have facilitated the development of clinical trials to define the principles for
Treatment with zidovudine (AZT) is not associated with increased B cell activation in HIV infection (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 35:A1137 1994. Unique Identifier : AIDSLINE ICDB/94602823; Widney D; Vander Meyden M; Martinez-Maza O; Dept. of Microbiology and Immunology, UCLA Sch. of Medicine, Los; Angeles, CA 90024; An increased frequency of AIDS-associated lymphoma has been reported to be associated with AZT treatment. B cell hyperactivation, which is often seen in HIV infection, is thought to contribute directly to the development of lymphoma. To determine if A
Liposome encapsulated doxorubicin for the treatment of AIDS-associated Kaposi's sarcoma (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 35:A1139 1994. Unique Identifier : AIDSLINE ICDB/94602825; Harrison M; Coker R; Tomlinson D; Stewart S; Dept. of Oncology, St Mary's Hosp., London W2 1NY, UK; Severe KS requiring chemotherapy affects 20-30% of patients with AIDS. Doxorubicin within a polyethylene glycol containing liposome (Doxil, LTI) has been used in a phase 2 study on 34 patients with severe KS. The liposome is 90 nm in diameter and is composed of 20% cholesterol, 20% polyethylene glycol, and 60% phospha
Pediatric HIV associated non-Hodgkin's lymphomas (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 35:A1140 1994. Unique Identifier : AIDSLINE ICDB/94602826; Shad A; Bhatia K; Hamdy N; Mueller B; Pizzo P; Whang Peng J; Jaffe E; Magrath I; Pediatric Branch, Pathology Dept., NCI, Bethesda, MD 20892; HIV infected children, like HIV infected adults, are at increased risk for development of non-Hodgkin s lymphomas (NHL). However, there is very little information available on the histological, cytogenetic and molecular features of pediatric HIV associated NHLs. We present here the pathological and biological features
HIV lymphomas frequently carry mutations in the c-myc protein (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 35:A1141 1994. Unique Identifier : AIDSLINE ICDB/94602827; Spangler G; Gaidano G; Hamdy N; Dalla-Favera R; Magrath I; Bhatia K; Pediatric Branch, NCI, Bethesda, MD 20892; Non-Hodgkin s lymphomas, particularly high grade B cell lymphomas, are the most frequent malignancies diagnosed in patients infected with HIV. We have previously reported the occurrence of point mutations in the protein coding region of c-myc in approximately 60% of SNCL in non-HIV infected patients. We have now scree
Proliferation of leiomyosarcoma cell lines is inhibited in vitro by antisense oligonucleotides directed against the insulin growth factor Type I receptor (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 35:A1543 1994. Unique Identifier : AIDSLINE ICDB/94603229; Hirschfeld S; Helman LJ; Pediatric Branch, NCI, Bethesda, MD; Smooth muscle proliferation can lead to a variety of pathologic conditions, including benign (leiomyoma) and malignant (leiomyosarcoma; LMS). Published studies have shown that smooth muscle cell proliferation can be enhanced by insulin growth factor I (IGF-I), and that surgical specimens of LMS contain RNA transcripts
Hyperstabilization of sense-antisense duplexes and inhibition of translation (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 35:A1835 1994. Unique Identifier : AIDSLINE ICDB/94603521; Kim DY; Shih DS; Cho DY; Swenson DH; School of Veterinary Medicine, Louisiana State University, Baton; Rouge, LA 70803; The antitumor agents CC-1065 and U-71,184 raise the Tm of double-stranded DNA. We undertook this study to determine if these agents could hyperstabilize RNA-DNA (sense-antisense) duplexes or DNA duplexes in which one strand contained phosphorothioate (PS) or methylphosphonate (MP) internucleotide linkages. Sequences 1
Mechanism of disproportionate antiviral activity of 2',3'-dideoxynucleoside analogs and their classification (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 35:A1841 1994. Unique Identifier : AIDSLINE ICDB/94603527; Gao WY; Agbaria R; Driscoll JS; Mitsuya H; NCI, Bethesda, MD 20892; The mechanism of disproportionate anti-HIV-1 activity of 2 ,3 -dideoxynucleoside (ddN) in resting and activated target cells was studied. The in vitro activity of various ddNs against human immunodeficiency type 1 (HIV-1) profoundly differed from each other. The divergent antiviral activity was associated with differe
Increased survival of immunodeficient retrovirus infected mice treated with lithium (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 35:A1824 1994. Unique Identifier : AIDSLINE ICDB/94603528; Gallicchio VS; Cibull ML; Hughes NK; Tse KF; Hematology and Oncology Division, Department of Internal; Medicine, University of Kentucky Medical Center, Lexington, KY; 40536; Murine immunodeficiency virus disease (MAIDS) induced with LP-BM5 MuLV shows many similarities to human HIV-infection. The etiological agent is a defective MuLV capable of inducing disease with the aid of a helper virus. Lithium (Li) influences numerous immunohematopoietic cell types and cellular processes that involv
Analysis of peripheral lymphocytes of lymphoma patients for daunomycin (DNR) retention and cell differentiation antigens (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 35:A1846 1994. Unique Identifier : AIDSLINE ICDB/94603532; Samy TS; Byrnes J; Krishan A; Harrington WJ Jr; Byrnes G; Wellham LL; Sauerteig A; Fletcher MA; University of Miami School of Medicine, Miami, FL 33136; The lymph node cells and peripheral blood lymphocytes of lymphoma patients were analyzed for cellular DNR retention, response to efflux blockers and expression of human differentiation antigens. Extensive heterogeneity in cellular DNR retention was seen in lymphocytes in 10/66 patients. Cellular DNR retention could be
Synthesis and antiviral evaluation of 2',3'-dideoxy-L-pyrimidine nucleosides with an improved in vitro therapeutic index against hepatitis B and human immunodeficiency virus (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 35:A1848 1994. Unique Identifier : AIDSLINE ICDB/94603534; Lin TS; Luo MZ; Liu MC; Pai SB; Dutschman GE; Cheng YC; Dept. of Pharmacology, Yale Univ. School of Medicine, New Haven,; CT 06510; The limiting toxicity of the clinically approved antiviral drug 2 ,3 -dideoxycytidine (beta-D- ddC ) is peripheral neuropathy , which may be caused by the inhibition of mitochondrial DNA synthesis. Vario
Protective effects of swainsonine against toxicity of chemotherapeutic drugs (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 35:A1909 1994. Unique Identifier : AIDSLINE ICDB/94603595; Klein JL; George MD; Roberts JD; Kurtzberg J; Breton P; Chermann JC; Olden K; Lab of Molecular Carcinogenesis, NIEHS, Research Triangle Park,; NC 27709; Swainsonine, a plant-derived alkaloid, abrogates the cytotoxicity of drugs commonly used in cancer and AIDS therapy. In a murine bone marrow progenitor colony-forming assay, as previously published, CFU-E were more sensitive to AZT toxicity than were
Edema induced by factors released by AIDS-associated Kaposi's sarcoma cells (AIDS-KS cell) (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 35:A402 1994. Unique Identifier : AIDSLINE ICDB/94602090; Nakamura S; Murakami-Mori K; Sakurada S; Rajeeve S; Rao N; Weich H; Salahuddin SZ; Inst. of Molecular Medicine and Technology, Pasadena, CA 91105; Angiogenesis and in some cases edema are two major components of AIDS-KS. Cultured spindle cells isolated from various KS lesions of patients with AIDS transplanted in nude mice induce KS-like lesions of murine origin. The critical factor for this purpose is oncostatin H. We report here that AIDS-KS cells also release
Replication inhibition and miscoding properties of a DNA template containing N-(deoxyguanosin-8-yl)-1-aminopyrene (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 35:A854 1994. Unique Identifier : AIDSLINE ICDB/94602541; Vyas RR; Basu AK; Dept. of Chemistry, Univ. of Connecticut, Storrs, CT 06269; A major DNA adduct formed by the environmental pollutant 1-nitropyrene is N-(deoxyguanosin-8-yl)-1-aminopyrene (dG(AP)). We have synthesized a DNA fragment that contained this adduct at a specific site. A primer was annealed to this template and in vitro DNA synthesis by a variety of polymerases was studied. Primer ex
Growth suppression and toxicity induced by caffeic acid phenethyl ester (CAPE) in type 5 adenovirus transformed rat embryo cells correlates directly with transformation progression (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 35:A979 1994. Unique Identifier : AIDSLINE ICDB/94602665; Su ZZ; Lin J; Grunberger D; Fisher PB; Columbia University, College of Physicians and Surgeons, New; York, NY 10032; The active component of the honeybee hive product propolis, CAPE, induces a selective growth suppressive and toxic effect toward cloned rat embryo fibroblast (CREF) cells transformed by adenovirus type 5 (Ad5) or the Ad5 E1A transforming gene versus untransformed CREF cells. The present study was conducted to determin
Chemotherapy associated with zidovudine and Gm-CSF in human immunodeficiency virus-related non-Hodgkin's lymphoma (HIV-NHL) (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 35:A1138 1994. Unique Identifier : AIDSLINE ICDB/94602824; Gabarre J; Lepage E; Thyss A; Bastion Y; Sebban C; Schlaifer D; Ribrag V; Fereres M; Raphael M; Gisselbrecht C; GELA, Saint-Louis Hosp., Paris, France; HIV-NHL patients have an estimated survival according to authors between 5-9 months, a better survival can be obtained in patients with a good performance status (PS), CD4 count greater than 100 ul/mm3 and without AIDS. Main causes of death are lymphoma, opportunistic infections and therapy toxicity. In order to reduc
Analysis of strand transfer synthesis by reverse transcriptases.: Diss Abstr Int [B]; 54(7):3597 1994. Unique Identifier : AIDSLINE ICDB/94605826; Buiser RG; Univ. of Rochester; Models of retrovirus replication require the viral reverse transcriptase (RT) to catalyze two distinct strand transfer reactions. In this process, an RNA primer is elongated on one template and then transferred to another template for additional elongation. It is thought that the RT ribonuclease H (RNase H) activity i
Lack of inhibition of HIV replication in chronically infected macrophages by Tat inhibitors Ro-5-3335 and Ro-24-7429.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:100 (poster no. 51). Unique Identifier : AIDSLINE ASHM5/94348910; Dunne A; Siregar H; Sonza S; Crowe S; Macfarlane Burnet Centre for Medical Research, Fairfield; Hospital, Vic.; OBJECTIVE: HIV infects different cell types including CD4+ lymphocytes and monocyte/macrophages (Mphi). We have examined the effect of the Tat inhibitors Ro-5-3335 and Ro-24-7429 in cultured human peripheral Mphi. METHODS: MO were isolated from HIV seronegative donors by gradient centrifugation and plastic adherence.
Optimisation of microculture methods for quantitation of HIV from plasma and cellular fractions of peripheral blood.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:100 (poster no. 50). Unique Identifier : AIDSLINE ASHM5/94348911; Dunne A; Crowe S; Macfarlane Burnet Centre for Medical Research, Fairfield; Hospital, Victoria.; OBJECTIVE: Quantitation of HIV in plasma and PBMCs is used in clinical trials to follow disease progression and determine drug efficacy. We have modified the ACTG protocols to reduce cost and optimise virus isolation. METHODS: Microculture procedures as described by the AIDS Clinical Trials Group (ACTG) have been used
Lymphocyte subset analysis by Boolean algebra: a phenotypic approach using a cocktail of 5 antibodies and 3 colour immunofluorescence.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:101 (poster no. 52). Unique Identifier : AIDSLINE ASHM5/94348912; Hunter S; Peters L; Wotherspoon J; Crowe S; Flow Cytometry Unit, Macfarlane Burnet Centre for Medical; Research, Fairfield Hospital, Victoria, Australia.; A rapid method has been developed whereby total CD3+ T-cells, CD4+ T-cells (CD3+CD4+), CD8+ T-cells (CD3+CD8+), putative gamma delta-receptor-T-cells (CD3+CD4-CD8-) and T-cells that are CD3+CD4+CD8+ as well as B-lymphocytes and NK-cells can be enumerated after staining in a single tube. Whole blood specimens are label
Mechanisms of AZT resistance in HIV isolates.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:101 (poster no. 53). Unique Identifier : AIDSLINE ASHM5/94348913; Buchanan L; Tachedjian G; Birch C; Virology Department, Fairfield Hospital, Victoria.; AIM: To investigate the susceptibility of the reverse transcriptase (RT) and ribonuclease H (RNase H) from AZT-sensitive (AZT-S) and AZT-resistant (AZT-R) HIV isolates to AZT-triphosphate (AZTTP) and AZT-monophosphate (AZTMP). METHODS: Isolates obtained from a patient before and after long-term AZT therapy were examin
Characterisation of putative steroid response elements in the long terminal repeat of HIV-1.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:102 (poster no. 55). Unique Identifier : AIDSLINE ASHM5/94348914; Barnes N; Deacon N; Doherty R; Macfarlane Burnet Centre, Fairfield, Vic.; Motifs with sequence homology to steroid hormone response elements have been identified in the upstream half of the LTR of HIV by several investigators, and nuclear factors have been identified in HeLa cell extracts which bind to these regions. The motifs appear conserved in HIV consensus sequences, and to a variable
Mechanism of action of Coumermycin A1.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:102 (poster no. 54). Unique Identifier : AIDSLINE ASHM5/94348915; Jardine D; Locarnini S; Tachedjian G; Birch C; Virology Dept., Fairfield Hospital, Victoria.; AIM: To investigate the mechanism of action of Coumermycin A1 against HIV. METHODS: We investigated the in vitro anti HIV activity of coumermycin A1 in acutely infected PBLs, T-cell lines (MT-2) and macrophages and in chronically infected cells (H9-HTLVIIIB and macrophages). Several in vitro assays, such as reverse tr
Characterisation of HIV-1 LTR DNA-binding proteins.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:103 (poster no. 57). Unique Identifier : AIDSLINE ASHM5/94348916; Peters A; Deacon NJ; AIDS Molecular Biology Laboratory, Macfarlane Burnet Centre for; Medical Research, Fairfield, Vic., Australia.; An investigation into the characterisation of mammalian nuclear proteins which bind to the HIV-1 LTR U3 region has been carried out using a series of overlapping 40-mer oligonucleotides. These oligonucleotides were synthesised to correspond to the HXB2 sequence from n.t. -210 to n.t. -454. Two oligonucleotides have sh
Role the immunodeficiency virus nef gene and the production in CNS tropism.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:103 (poster no. 56). Unique Identifier : AIDSLINE ASHM5/94348917; Smith K; Deacon NJ; McPhee DA; Brew B; AIDS Molecular Biology Unit, Macfarlane Burnet Centre, Vic.,; Australia.; Particular strains of HIV may dominate the CNS of infected individuals and it is possible that the HIV Nef protein plays a role in differentiating CNS and peripheral blood isolates. To address this, 6 pairs of coincident isolates from the CSF and peripheral blood of patients with AIDS or ARC were analysed for their ab
Cytokine dysregulation associated with the course of HIV infection.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:104 (poster no. 58). Unique Identifier : AIDSLINE ASHM5/94348918; Fan J; Bass H; Nguyen T; Fahey JL; National Centre for HIV Virology Research, Institute of Medical; and Veterinary Science, Adelaide, South Australia.; By using quantitative RT-PCR, elevated levels of IFN gamma mRNA and lowered IL-2 mRNA were found in PBMC of HIV-seropositive men with CD4 T cells over 500/mm3 (mean:647/mm3) while IL-4 and IL-10 mRNAs did not change significantly. Men whose CD4 levels fell more than 20
Detection of HIV-1 tat, rev and nef mRNA at single cell level.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:104 (poster no. 59). Unique Identifier : AIDSLINE ASHM5/94348919; Peng H; Haase AT; National Centre for HIV Virology Research, Institute of Medical; and Veterinary Science, Adelaide, South Australia.; We have developed a strategy of in situ hybridisation using splice-junction probes which can specifically detect HIV-1 regulatory and structural gene mRNAs. This approach takes advantage of the fact that although tat, rev and nef share the same 5 splice donor, they differ in their use of the first splice acceptors. E
Primary T-cell response to HIV-1 in vitro.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:105 (poster no. 60). Unique Identifier : AIDSLINE ASHM5/94348920; Todd B; Pope J; NCHVR, Royal Children's Hospital, Brisbane, Qld.; HIV-I-specific, MHC-restricted cytotoxic T cells may be detected directly in peripheral blood (PB) of HIV-1-infected patients, and cytotoxic T-cell lines can be established in vitro. CD8+ T cells predominate, and epitopes exist in most viral antigens. Generation of cytotoxic T cells from the PB mononuclear cells from
Transcription factors in HIV-1 infection.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:105 (poster no. 61). Unique Identifier : AIDSLINE ASHM5/94348921; Kedar P; Arden KE; Todd BJ; Pope JH; NCHVR, Royal Children's Hospital, Brisbane, Qld.; Transcriptional regulation involves the interaction of enhancer-promoter regions with cellular binding proteins. NF-kB is a nuclear transcriptional factor which binds and mediates transcription from the sequences in the promoter region. In our system we have studied NF-kB and related proteins in PHA stimulated cord bl
CD4-bearing human thymic dendritic cells as potential targets for HIV infection.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:106 (poster no. 63). Unique Identifier : AIDSLINE ASHM5/94348922; Sotzik F; Shortman K; Walter and Eliza Hall Institute of Medical Research, Royal; Melbourne Hospital, Parkville, Victoria.; The intention of the project was the isolation of CD4-bearing T-precursor thymocytes. This laboratory has found these to be the earliest T-precursors in the murine thymus with T cell receptor genes in the germline, unrearranged state. In order to identify the human equivalent, CD34 and CD7 expression has been examined
HIV strains and the proliferative response of mononuclear cells from normal donors.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:106 (poster no. 62). Unique Identifier : AIDSLINE ASHM5/94348923; Adams S; Todd B; Pope J; NCHVR, Royal Children's Hospital, Brisbane, Qld.; Recent interest has focused on the different biological properties of HIV-1 isolates. Non-syncytium-inducing (NSI) isolates, detectable at all stages of HIV infection, are preferentially monocytotropic in contrast to SI isolates which precede symptoms of AIDS and are T-cell tropic. We are examining the effects of NSI
DdI susceptibility of HIV-1 isolates in patients on long-term therapy.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:107 (poster no. 64). Unique Identifier : AIDSLINE ASHM5/94348924; Land S; McGavin C; Corby S; Tyssen D; Gorry P; Magliano D; Birch C; State HIV Isolation Laboratory, Virology Department, Fairfield; Hospital, Victoria.; Sequential HIV isolates obtained from 18 individuals receiving dideoxyinosine (ddI) were tested for susceptibility to the drug. All patients had received AZI before commencing ddI therapy for up to 18 months. Susceptibility assays were performed in peripheral blood lymphocytes infected with these isolates and maintain
Detection of HIV-1(HTLV-I) pseudotypes.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:107 (poster no. 65). Unique Identifier : AIDSLINE ASHM5/94348925; Lawson V; Doultree J; Lee JY; Marshall J; McPhee D; Macfarlane Burnet Centre for Medical Research, NCHVR, Fairfield,; Vic.; The mixing of envelope glycoproteins in cells infected with two viruses may result in the formation of pseudotypes. Several studies have indicated that human immunodeficiency virus (HIV) may form pseudotypes with several viral species including human T-cell leukemia virus (HTLV-I), murine amphotropic virus and HIV-2.
HIV regulatory and accessory gene mRNAs.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:108 (poster no. 66). Unique Identifier : AIDSLINE ASHM5/94348926; Smith J; Penschow J; Deacon NJ; AIDS Molecular Biology Lab, Macfarlane Burnet Centre for Medical; Research, Fairfield, Vic.; The regulatory and accessory proteins of human immunodeficiency virus type 1 (HIV-1) are produced from singly or multiply spliced mRNAs. We have used HIV-1 specific oligonucleotide primer pairs in a polymerase chain reaction procedure on cDNA reverse transcribed from cytoplasmic RNA extracted from lymphocytic cell lin
The study of Nef mutant clones of human immunodeficiency virus (HIV).: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:108 (poster no. 67). Unique Identifier : AIDSLINE ASHM5/94348927; Arunagiri CK; Peden K; Azad A; McPhee D; Biomolecular Research Institute, Parkville.; A study was initiated to determine the function of Nef auxiliary protein replication of HIV. A molecular clone of HIV, LAI, was selected and two truncated (termination at amino acid 46 and 88) nef mutant clones constructed. The proviral DNA of the mutants and wild type were used to transfect Hela cells. Virus produced
Induced expression of HIV-1 genomic RNA in latently infected cells followed tat, but preceded rev, mRNA expression.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:109 (poster no. 68). Unique Identifier : AIDSLINE ASHM5/94348928; Peng H; Haase AT; National Centre for HIV Virology Research, Institute of Medical; and Veterinary Science, Adelaide, South Australia.; The kinetics of individual viral RNA synthesis of HIV-1 regulatory and structural genes in ACH2 cells after PMA induction were analysed at the single cell level using in situ hybridisation with splice-junction probes. Before PMA stimulation, only a small fraction (
PCR analysis for common HIV-1 zidovudine resistance mutations in pol DNA of untreated and zidovudine treated patients.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:109 (poster no. 69). Unique Identifier : AIDSLINE ASHM5/94348929; Salem H; Nightingale B; Garsia RJ; Molecular Biology Department, Royal Prince Alfred Hospital,; Camperdown, NSW.; METHODS: Mutations of the HIV-1 pol gene, causing amino acid changes at codons 41, 67, 70, 215 and 219, were sought in DNA of serial HIV-1 infected patients. Exposure to Zidovudine (ZDV) was nil in 12 cases and ranged from 36 months in the remaining 55 samples. The PCR amplified two regions of pol encom
Mechanisms of AZT resistance in HIV isolates.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:110 (poster no. 70). Unique Identifier : AIDSLINE ASHM5/94348930; Buchanan L; Tachedjian G; Birch C; NCHVR, Fairfield Hospital, Victoria.; To investigate the susceptibility of the reverse transcriptase (RT) and ribonuclease H (RNase H) from AZT-sensitive (AZT-S) and AZT-resistant (AZT-R) HIV isolates to AZT-triphosphate (AZTTP) and AZT-monophosphate (AZTMP). METHODS--Isolates obtained from a patient before and after long-term AZT therapy were examined fo
In-field assay monitoring of anti-HIV-1/HIV-2 EIAs in Australian Blood Banks, 1992. Australian Red Cross Blood Transfusion Service Laboratories.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:111 (poster no. 72). Unique Identifier : AIDSLINE ASHM5/94348931; Dax EM; Bendistinto M; Vandenbelt T; National HIV Reference Laboratory (NRL), Fairfield Hospital,; Victoria, Australia.; OBJECTIVE: To examine the performance of 4 anti-HIV-1/HIV-2 enzyme immunoassays (EIAs) in Australian Blood Banks during use. EIAs included: Abbott Recombinant, Diagnostic Pasteur Genelavia MIXT, Genetic Systems EIA and Organon Teknika. METHODS: Anti-HIV-1/HIV-2 EIAs were monitored by collecting data from individual la
Modelling the HIV-1 infection cycle.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:112 (poster no. 73). Unique Identifier : AIDSLINE ASHM5/94348932; Deacon N; McPhee D; Newnham J; Linger H; AIDS Molecular Biology Unit, Monash University.; We have developed a computational tool for biological research to study the replication strategy of the human immunodeficiency virus. This model incorporates a formal model using Petri Nets and scientific citations. In the development of the formal model we have uncovered some facets of the replication strategy that w
Management of HIV disease.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:18 (abstract no. TPI-1). Unique Identifier : AIDSLINE ASHM5/94348933; Volberding P; San Francisco General Hospital.; Appropriate clinical care of the HIV-infected patient includes consideration of antiretroviral therapy, opportunistic infection, management, and the treatment of HIV-associated malignancies. In addition, the system of care must address the numerous psychosocial issues posed by progressive fatal disease, typically occu
Antiretroviral therapy of HIV: a virologists perspective.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:19 (abstract no. TPI-4). Unique Identifier : AIDSLINE ASHM5/94348934; Corey L; University of Washington, Seattle.; While the availability of nucleoside reverse transcriptase (RT) inhibitors have revolutionised care of HIV infected persons, controversy exists about the overall utility of these medications. When should therapy be initiated? With what agent? When should alternative therapy be utilised, what alternative should be give
Contamination of blood by HIV in France: facts, controversies and impact on society.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:19 (abstract no. TPI-3). Unique Identifier : AIDSLINE ASHM5/94348935; Brunet JB; European Centre for the Epidemiology Monitoring of AIDS,; Saint-Maurice, France.; Screening of blood donors has been mandatory in France since 1st August 1985. Virus inactivated Factor VIII concentrates were progressively introduced for treatment of haemophiliacs and by 1st October 1985 all non-heated products had been replaced. By 30th June 1993, 1223 AIDS case
Unravelling the molecular biology of HIV.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:20 (abstract no. TPI-5). Unique Identifier : AIDSLINE ASHM5/94348936; Rosenberg M; SmithKline Beecham Pharmaceuticals, King of Prussia, PA; 19406-0939.; HIV is a genetically complex retrovirus which can integrate into the genome of its human host and thereby remain hidden from immune surveillance or replicate slowly to achieve its chronic infection process. The advent of the recombinant DNA technologies have allowed identification, molecular dissection and characteris
Ian Thompson Memorial Lecture. Opportunistic infections in people with HIV.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:21 (abstract no. TPI-6). Unique Identifier : AIDSLINE ASHM5/94348937; van der Horst C; University of North Carolina.; In the last 10 years of the HIV epidemic therapeutic advances on the frontier of opportunistic infections have done more to prolong the quality and length of life for affected people than anti-retrovirals. Pneumocystis carinii pneumonia is less often seen due to widespread prophylaxis with trimethoprim-sulfamethoxazol
Drug resistance and Sl phenotype; implications for chemotherapy.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:22 (abstract no. FPI-2). Unique Identifier : AIDSLINE ASHM5/94348938; Richman DD; University of California San Diego 92093-0679.; The clinical and therapeutic significance of the emergence of diminished drug susceptibility has been difficult to elucidate. Two recent studies, one with nucleosides and one with a non-nucleoside reverse transcriptase inhibitor (NNRTI) address this issue. A multicenter virologic analysis of ACTG 116B/117 documented t
HIV vaccines.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:22 (abstract no. FPI-1). Unique Identifier : AIDSLINE ASHM5/94348939; Corey L; McElrath J; Kent S; Greenberg P; University of Washington, Seattle.; To date the NIAID sponsored AIDS Vaccine Evaluation Group (AVEU) has enrolled over 1000 patients into Phase I/II clinical trials of candidate HIV vaccines. 8 different envelope products have been evaluated including two gp160 preparations, two subunit gp120 products, one yeast derived gp120, one vaccinia gp160, 1 cana
Clinical management of HIV-related malignancies.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:23 (abstract no. FPI-3). Unique Identifier : AIDSLINE ASHM5/94348940; Volberding P; San Francisco General Hospital.; Two cancers are recognised as occurring in a higher rate in patients with HIV infection. These include non-Hodgkin s B cell lymphomas and Kaposi s sarcoma. In addition, some data indicates that Hodgkin s disease may also occur at an increased incidence. Many other malignancies have been reported in patients infected w
HIV related dementia.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:23 (abstract no. FPI-4). Unique Identifier : AIDSLINE ASHM5/94348941; Strain J; This paper will address the prevalence, the etiology, and the treatment of the organic mental disorders that accompany HIV infection, with special attention to the dementias. Late-stage HIV infection is frequently associated with a syndrome of progressive dementia, presumably etiologically related to the virus activit
Cytomegalovirus infections in people with HIV.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:24 (abstract no. SPI-2). Unique Identifier : AIDSLINE ASHM5/94348942; van der Horst C; University of North Carolina.; By the time of death up to 40% of HIV infected people will develop life or sight threatening CMV infections. With some rare exceptions most of these infections will occur when the CD4 count drops below 100 cells/mm3 and usually do not occur until the CD4 count i
Update of HIV drug resistance.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:24 (abstract no. SPI-1). Unique Identifier : AIDSLINE ASHM5/94348943; Larder B; Antiviral Therapeutic Research Unit, Wellcome Research; Laboratories, U.K.; Initial reports that human immunodeficiency virus (HIV) isolates from individuals with advanced disease can become resistant to AZT after prolonged therapy precipitated considerable interest in the study of HIV drug resistance. Genetic analysis of the
Molecular targets for HIV therapy.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:25 (abstract no. SPI-3). Unique Identifier : AIDSLINE ASHM5/94348944; Rosenberg M; SmithKline Beecham Pharmaceutical, King of Prussia, Pennsylvania; 19406-0939.; There continues to be an urgent need for the discovery and design of better drugs with antiviral activities against the HIV viruses. The various stages of the HIV life cycle provide specific molecular targets for which novel assays and mechanistic approaches can be developed to search for and identify new inhibitory a
An unusual cause of nodular pulmonary opacities in HIV.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:26 (abstract no. TC-2). Unique Identifier : AIDSLINE ASHM5/94348945; Lewin SR; Macfarlane Burnet Centre for Medical Research, Fairfield,; Victoria.; Nodular pulmonary infiltrates are a difficult diagnostic problem in HIV infection. Various modalities of investigation are available to the clinician including bronchoscopy, CT guided and open lung biopsy as well as nuclear medicine studies. Infrequently, no diagnosis may be made. A 37 year old man with multiple AIDS
Pneumonitis in association with primary HIV illness.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:26 (abstract no. TC-1). Unique Identifier : AIDSLINE ASHM5/94348946; Kelly M; Lloyd A; Jones P; Department of Infectious Diseases, Prince Henry Hospital, Little; Bay, Sydney.; A 27 year old homosexual male presented initially with a 5 day illness characterised by fever and rash. Apart from a maculopapular rash there was no physical abnormality. The symptoms resolved spontaneously over a four day period. At presentation P24Ag was positive and then became negative whereas tests for HIV antibo
A cavitating lung infection followed by cytomegalovirus polyradiculopathy--discussion of two problems.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:27 (abstract no. TC-4). Unique Identifier : AIDSLINE ASHM5/94348947; Empson M; Britton W; Garsia R; Department of Clinical Immunology, Royal Prince Alfred Hospital,; Camperdown, NSW.; A 29 year old HIV positive man presented with pleuritic chest pain. haemoptysis and epistaxis. Investigations revealed a cavitating lung lesion, high titre cANCA and scanty pneumocysts. The course was complicated by clinical hypoadrenalism, secondary infection and delirium. CSF obtained to investigate the latter grew
Case presentation: a 35 year old man with cystic pneumocystis pneumonia, cerebro-ocular lymphoma and recurrent bacteraemia.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:27 (abstract no. TC-3). Unique Identifier : AIDSLINE ASHM5/94348948; Paterson DL; Allworth AM; Hospital Brisbane, Australia.; A 35 year old man HIV antibody positive since 1986 presented in February 1993 with pleuritic chest pain haemoptysis and dyspnoea. His past history included syphilis, bacillary angiomatosis , Kaposi s sarcoma and CMV reti
HIV related chronic reactive/suppurative airway disease: is CMV important?: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:28 (abstract no. TC5). Unique Identifier : AIDSLINE ASHM5/94348949; Parkin D; Pigott P; Dept. of HIV Medicine, Royal North Shore Hospital, St Leonards,; NSW.; We describe a case of HIV related chronic reactive/suppurative airway disease in a non smoking 47 year old man. He had longstanding HIV infection treated with sporadic AZT . His initial complication was Pneumocystis carinii pneumonia in May 1992. He re
Resistant fungal infections in AIDS--an emerging problem.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:28 (abstract no. TC6). Unique Identifier : AIDSLINE ASHM5/94348950; Woolley I; Fuller A; Franklin C; Hale C; Vujovic O; Russell P; Spelman D; Spicer WJ; Department of Microbiology and Infectious Diseases, Alfred; Hospital, Prahran.; 1. CANDIDIASIS. We discuss 3 patients who developed severe symptomatic oral candidiasis. Clinical resistance to ketoconazole and fluconazole occurred over time, necessitating the use of intravenous amphotericin in two patients. Disc sensitivity testing of their isolates with Neosensitabs confirmed the resistance. 2. C
Transient ischaemic attacks (TIAs) in HIV infection.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:29 (abstract no. TC7). Unique Identifier : AIDSLINE ASHM5/94348951; Brew BJ; Miller J; HIV Medicine Unit, St Vincent's Hospital, Australia.; OBJECTIVE: TIAs in HIV infection may occur as a result of an underlying infection or neoplasm and seemingly as a consequence of HIV itself. The frequency, clinical characteristics and results of investigations of those TIAs that occur independent of an underlying infection or neoplasm, however, have not been defined a
IgM antibodies against complex glycolipids of peripheral myelin in human immunodeficiency virus (HIV) infection.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:30 (abstract no. TC9). Unique Identifier : AIDSLINE ASHM5/94348952; Petratos S; Papadopoulos R; Turnbull V; Ayers M; Gonzales MF; Department of Anatomical Pathology, Royal Melbourne Hospital,; Parkville, Victoria.; IgM antibodies against complex glycolipids, in particular GM1, GD1b and GQ1b gangliosides have been detected in the plasma of patients with acute and chronic inflammatory demyelinating polyneuropathy, multi-focal motor neuropathy and motor neurone disease. Inflammatory demyelinating neuropathy is one of several neurop
Progressive multifocal leucoencephalopathy--the Fairfield Hospital experience.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:30 (abstract no. TC8). Unique Identifier : AIDSLINE ASHM5/94348953; Marshall C; Jennens I; Fairfield Hospital, Vic.; Progressive multifocal leucoencephalopathy (PML) is a cerebral infection caused by JC virus occurring in immunocompromised people. It has been well described in transplant recipients requiring immunosuppressive therapy and more recently in people immunosuppressed with human immunodeficiency virus (HIV). PML is estimat
Acetylation phenotype and hypersensitivity (HS) to trimethoprim-sulphamethoxazole (TMP-SMX) in HIV-infected patients.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:31 (abstract no. TC11). Unique Identifier : AIDSLINE ASHM5/94348954; Carr A; Gross A; Cooper DA; Centre for Immunology, St. Vincent's Hospital.; AIMS: HS to TMP-SMX is more common in patients with HIV infection. In those without HIV infection, HS is more common in those with a slow acetylator phenotype. A study was conducted to determine if the slow acetylation phenotype is associated with an increased risk of HS to TMP-SMX in patients with HIV. METHODS: Acety
Growth, characterisation and seroprevalence of an encephalitozoon SP from an AIDS patient with disseminated microsporidiosis.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:31 (abstract no. TC10). Unique Identifier : AIDSLINE ASHM5/94348955; Doultree JC; Ryan N; Druce J; Maerz A; Crowe S; Marshall J; Fairfield Hospital, Victoria.; Although microsporidia (MS) are important opportunistic pathogens in Acquired Immunodeficiency Syndrome (AIDS) patients, the in vitro characteristics and seroprevalence of many human species are poorly understood. Light microscopy and electron microscopy confirmed the presence of Encephalitozoon sp spores from a nasop
HIV related Mycobacterium tuberculosis (M.Tb) at Fairfield Hospital.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:32 (abstract no. FC1). Unique Identifier : AIDSLINE ASHM5/94348956; Wright EJ; Sarr A; Dwyer B; Hoy J; Fairfield Hospital, Vic.; OBJECTIVE: To review the clinical and laboratory features, management and outcome of M.tuberculosis in 18 HIV seropositive patients (2.5% of the total AIDS patients). METHODS: A retrospective review of case records and laboratory results of 16 male and 2 female patients attending Fairfield Hospital between January 198
Mediastinal tuberculosis with oesophageal perforation.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:32 (abstract no. FC2). Unique Identifier : AIDSLINE ASHM5/94348957; Dore G; St Vincent's Hospital, Darlinghurst, Sydney.; A 43 year old homosexual man, known seropositive for Human Immunodeficiency Virus (HIV) since 1984, with a CD4 Lymphocyte count of 40 x 109/ml, but with no prior Acquired Immunodeficiency Syndrome (AIDS) defining illness, presented with a three-week history of fevers, non-productive cough, pleuritic chest pain and dys
An unusual mycobacterial infection with osteomyelitis and skin lesions in an HIV patient.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:33 (abstract no. FC4). Unique Identifier : AIDSLINE ASHM5/94348958; Street AC; Fairfield Hospital, Vic.; Atypical mycobacterial infections other than those due to Mycobacterium avium complex are very uncommon in HIV patients. This report describes a case of Mycobacterium haemophilum (MH) infection with skin, bone and bloodstream involvement. A 42 year old HIV positive male with no prior AIDS-defining illness and a CD4 co
HIV-related mycobacterial infections in Queensland.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:33 (abstract no. FC3). Unique Identifier : AIDSLINE ASHM5/94348959; Konstantinos A; Dawson D; Patel AM; Mycobacterial Reference Laboratory, Queensland Health, Brisbane.; Human Immunodeficiency Virus (HIV) related mycobacterial infections in Queensland (Qld) were studied to define which mycobacteria contribute to HIV-related disease in Qld and implications for management. Mycobacteria were isolated from 112 HIV patients in Qld from 1/7/85-22/1/93 (Mycobacterium tuberculosis complex [MT
An Australian man who died of Pneumocystis carinii pneumonia complicating the acquired immunodeficiency syndrome in 1981.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:34 (abstract no. SC1). Unique Identifier : AIDSLINE ASHM5/94348960; Gerrard JG; McGahan SL; Milliken JS; Mathys JM; Royal Prince Alfred Hospital, Camperdown NSW.; OBJECTIVE: To present the earliest Australian case of the acquired immunodeficiency syndrome (AIDS) reported to date. CLINICAL FEATURES: A 72 year-old man developed a prolonged illness beginning in February 1981 characterised by anorexia, malaise, weight loss and an episode of dermatomal zoster. In July he became incr
Sinusitus in the person with HIV infection.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:34 (abstract no. FC5). Unique Identifier : AIDSLINE ASHM5/94348961; van der Horst C; University of North Carolina.; Although sinusitus is not a fatal complication of HIV infection it is nonetheless a vexing problem for my patients. The incidence and severity worsens as CD4 count declines and is often associated with intranasal drug use. Higher IgE levels are associated with worse sinusitis and atopy. Treatment must include intranas
A case of HIV-2 infection in Victoria.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:35 (abstract no. SC2). Unique Identifier : AIDSLINE ASHM5/94348962; Breschkin A; Russell D; Crofts N; Locarnini S; Victorian Infectious Diseases Reference Laboratory, Fairfield; Hospital.; In June 1993 a serum sample from a high-risk patient was referred to the Victorian HIV Reference Laboratory at Fairfield Hospital for routine anti-HIV testing. The serum was repeatedly reactive (S/C0 = 3.7) by the Abbott HIV-1/HIV-2 EIA. Confirmatory testing by HIV-1 Western blot showed an indeterminate profile with m
Long term asymptomatic infection in six blood transfusion recipients with a single common donor.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:35 (abstract no. SC3). Unique Identifier : AIDSLINE ASHM5/94348963; Learmont J; Tindall B; Sullivan J; Dwyer D; Cunningham A; Wylie B; Red Cross Blood Transfusion Service NSW.; OBJECTIVES: To investigate the possibility of any additional recipients from the common donor and to further describe the health status of the group. RESULTS: 7 more donations were identified and 4 recipients traced and tested. 3 recipients of 1980 donations tested negative. A 77 year old female transfused in April 19
Zidovudine-resistant HIV-1 in primary infection.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:36 (abstract no. SC4). Unique Identifier : AIDSLINE ASHM5/94348964; Imrie A; Hurren L; Cunningham P; Vizzard J; Carr A; Gurusinghe A; Deacon N; Penny R; Cooper DA; Centre for Immunology, St Vincents's Hospital.; AIM: To assess the prevalence of transmitted zidovudine-resistant HIV in individuals who seroconverted after 1990. METHODS: HIV was isolated from 10 homosexual men with symptomatic primary HIV infection, and from their sexual partners when possible. Isolates obtained within the first two months following onset of symp
ZDV and ddI resistance in HIV isolated from patients enrolled in the alpha ddI trial.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:36 (abstract no. SC5). Unique Identifier : AIDSLINE ASHM5/94348965; Zheng N; McQueen PW; Hurren L; Imrie A; Evans L; Delaney SF; Penny R; Cooper DA; Centre for Immunology, St. Vincents Hospital, Sydney.; Progressive HIV disease continues to occur despite the therapeutic use of antiviral agents such as didanosine (ddI) a azidothymidine (ZDV) in the management of HIV infection. The means by which HIV-1 is able to overcome these chemotherapeutic challenges remains unclear at this time. It seems unlikely that a single cha
The Delta Study: one year later.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:37 (abstract no. SC6). Unique Identifier : AIDSLINE ASHM5/94348966; Rawlinson M; National Centre in HIV Epidemiology & Clinical Research,; Darlinghurst NSW.; STUDY OBJECTIVES AND METHODS: International randomised placebo controlled study comparing zidovudine ( AZT ) to combination AZT + dideoxycytidine( ddC ) or AZT + didanosine(ddI), in terms
Epidemiological aspects of HIV infection in Australian women.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:38 (abstract no. TE1). Unique Identifier : AIDSLINE ASHM5/94348967; Thackway SV; Furner V; Kaldor J; National Centre in HIV Epidemiology & Clinical Research,; Darlinghurst.; OBJECTIVE: To describe the characteristics of women with HIV-I infection in Australia . METHOD: The National Registry of Women with HIV Infection was established by merging the National HIV, AIDS, and Zidovudine Registries, using name codes and dates of birth. RESULTS: By March 1
The HIV risk-taking behaviour and perceptions of pregnant injecting drug users.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:38 (abstract no. TE2). Unique Identifier : AIDSLINE ASHM5/94348968; O'Neill K; Baker A; Cooke M; Collins EN; Wodak A; National Drug and Alcohol Research Centre, University of N.S.W.,; Kensington.; A sample of 94 pregnant injecting drug users (IDUS) were surveyed about their HIV risk-taking behaviour and perception of their risk of HIV infection. The women had been receiving methadone for varying periods, ranging from one week to 13 years (mean dose = 50 mg). In the month prior to interview, 93% had injected, 27
Perinatal exposure to HIV in Australia 1982-1993.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:39 (abstract no. TE4). Unique Identifier : AIDSLINE ASHM5/94348969; Cruickshank M; Ziegler JB; McDonald A; Prince of Wales Children's Hospital, Randwick.; OBJECTIVE: To describe the epidemiology of perinatal HIV exposure and transmission in Australia . METHODS: A registry of all cases of perinatal exposure to HIV was established using data retrieved retrospectively to test for possible factors affecting transmission rate, maternal c
Pregnancy and STDs: a study of the contraceptive practices of young sexually active women.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:39 (abstract no. TE3). Unique Identifier : AIDSLINE ASHM5/94348970; Lucke J; National Centre for HIV Social Research, Royal Brisbane Hospital,; Herston, Qld.; The aim of this study was to examine the relationship between condom use for disease prevention and the use of other contraceptives to prevent pregnancy among young women. Sexually active women aged between 16 and 24 who attended two Brisbane Family Planning Clinics were asked to complete a questionnaire. The questionc
Health care and costs of children with vertically acquired HIV infection in Australia.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:40 (abstract no. TE5). Unique Identifier : AIDSLINE ASHM5/94348971; Langdon P; Carlin JE; Ziegler J; Social Work Dept, Princess Margaret Hospital, Perth.; OBJECTIVES: To estimate lifetime costs of children with vertically acquired HIV infection and gather qualitative data on the clinical spectrum of disease and patterns of care of these children. METHODS: 33 of 38 eligible children were studied from 10 medical centres in 4 states and 1 territory. Study group included: cc
Heterosexual transmission of HIV: a European study.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:40 (abstract no. TE6). Unique Identifier : AIDSLINE ASHM5/94348972; Brunet JB; European Centre for the Epidemiological Monitoring of AIDS,; France.; From 1987 to 1991 563 couples were recruited from 9 countries in a cross-section study. 378 HIV(-) partners recruited in settings adapted for follow-up sectional study. 378 HIV(-) partners recruited in settings adapted for follow-up were included in the prospective study. At each interview partners were tested, intervc
Incidence of HBV and HCV in prison entrants in Victoria, 1991-92: evidence of a core risk group for HIV transmission.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:41 (abstract no. TE7). Unique Identifier : AIDSLINE ASHM5/94348973; Crofts N; Stewart T; Hearne P; Breschkin A; Locarnini S; Macfarlane Burnet Centre, Fairfield, Vic.; AIM: To measure incidence of blood-borne viruses among prison entrants, to assess risk in these populations for HIV transmission. METHODS: All entrants to Pentridge Prison between Oct91 and Oct92 were tested with consent for HIV/HBV/HCV; incidence rates were calculated for those tested more than once in the period. Lic
Unsafe sex among gay men: towards a new intervention strategy.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:41 (abstract no. TE8). Unique Identifier : AIDSLINE ASHM5/94348974; Gold R; Rosenthal D; Faculty of Education, Deakin University, Waurn Ponds, Vic.; OBJECTIVE. To examine the effectiveness of an intervention strategy based on men s justifications for breaking their own safe sex rules. METHOD: We report an intervention study in which 109 gay men who had slipped up (i.e., broken their safe sex rules by having unprotected intercourse) kept diaries of their sexual behc
HIV/AIDS education and sex education: do they encourage sexual experimentation in youth?: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:42 (abstract no. TE9). Unique Identifier : AIDSLINE ASHM5/94348975; Grunseit AC; Kippax S; National Centre for HIV Social Research (MU), Macquarie; University, North Ryde, NSW, Australia.; INTRODUCTION: The provision of HIV/AIDS & sexuality education (SE) to young people is one of the most hotly debated issues facing educationists today. A major point of friction is whether exposure to HIV/AIDS &/or SE encourages sexual experimentation. To investigate this question, a literature review by the Mac
Predictors of uaic amongst a sample of homosexually active men.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:42 (abstract no. TE10). Unique Identifier : AIDSLINE ASHM5/94348976; Kippax S; Crawford J; Rodden P; National Centre for HIV Social Research, School of Behavioural; Science, Macquaire University, NSW.; OBJECTIVES: To investigate the predictors of unprotected anal intercourse with casual partner/s (uaic) amongst a sample of homosexually active men. METHOD: 2,583 homosexually active men (sex with a man within the last 5 years) were interviewed about their sexual practice, type of sexual partner/s, HIV test status, att
Changing pattern of HIV diagnosis in Victoria. The Victorian Collaborative Group on HIV and AIDS Surveillance.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:43 (abstract no. FE2). Unique Identifier : AIDSLINE ASHM5/94348977; Stevenson E; Crofts N; Gertig D; Breschkin A; Macfarlane Burnet Centre for Medical Research, Fairfield.; OBJECTIVES: To describe changes in the pattern of HIV diagnosis in Victoria. METHODS: Data, including exposure category, are collected on all Victorians newly diagnosed with HIV infection. For those cases not attributed to homosexual contact exposure is further clarified with the patient s doctor. RESULTS: For 1986 to
Patterns of AIDS and HIV infection in European countries.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:43 (abstract no. FE1). Unique Identifier : AIDSLINE ASHM5/94348978; Brunet JB; European Centre for the Epidemiological Monitoring of AIDS,; Saint-Maurice, France.; 96,000 AIDS cases were reported in Europe by 30 June 1993, and the population of HIV-infected persons is around 500,000. The European region has a common system for AIDS reporting, with an AIDS definition incorporating pulmonary tuberculosis, invasive cervical cancer, and recurrent pneumonia. Incidence of reported cas
HIV infection in recipients of blood products from donors with identified dates of HIV seroconversion.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:44 (abstract no. FE3). Unique Identifier : AIDSLINE ASHM5/94348979; Ashton L; Learmont J; Luo K; Wylie B; Stewart G; Kaldor J; National Centre for HIV Epidemiology and Clinical Research,; Sydney.; OBJECTIVES: To study factors that influence survival time in HIV-infected transfusion recipients. METHODS: A registry of people with transfusion acquired HIV infection (TAHIV) in NSW was established by the Red Cross Blood Transfusion Service; annual follow-up was implemented in 1990. From the registry a group of 6 don
Occupational exposure to blood and body fluids in Australian hospitals.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:44 (abstract no. FE4). Unique Identifier : AIDSLINE ASHM5/94348980; MacDonald M; Elford J; Kaldor J; National Centre in HIV Epidemiology and Clinical Research,; Darlinghurst, NSW.; OBJECTIVE: To describe the reporting of occupational exposure to blood and body fluids in Australian hospitals. METHODS: In December 1992, questionnaires were sent to 70 teaching hospitals throughout Australia. Information was sought on procedures for the reporting and management of occupational exposure to blood and
The acquired immunodeficiency syndrome in the Northern Territory of Australia: an impending Fourth World epidemic?: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:45 (abstract no. FE5). Unique Identifier : AIDSLINE ASHM5/94348981; Heath T; Bowden F; Sheppard K; Currie B; Royal Darwin Hospital, Casuarina, N.T.; Until recently HIV infection in the Northern Territory (NT) has been an urban disease of non Aboriginal people. Risk factors for HIV infection and indicator diseases for AIDS have been similar to those found in other Australian States. There is concern however, given the demographics of other sexually transmitted dise
Assessing health service interventions in HIV-disease.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:46 (abstract no. SE1). Unique Identifier : AIDSLINE ASHM5/94348982; Beck EJ; Academic Department of Public Health, St. Mary's Hospital Medical; School, Imperial College, UK.; AIM: To assess the effectiveness of health service interventions in HIV-disease, pathophysiological indices need to be interpreted within the context of service utilisation and specific treatment received. This interrelationship will be demonstrated in terms of outcome of first AIDS defining (index) episode of Pneumoc
The NSW HIV/AIDS Ambulatory Services casemix study.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:46 (abstract no. SE2). Unique Identifier : AIDSLINE ASHM5/94348983; Donnelly C; Stewart K; Starkey G; Information Centre, NSW Health Department, North Sydney.; This study examines the range of ambulatory care services provided to people with HIV, or screened for HIV. It involved a 2 or 3 week prospective data collection of services provided on an ambulatory basis at 14 hospitals and clinics, including one private general practice. Data for ambulatory consultations, HIV scree
Changing age at diagnosis of HIV/AIDS among gay men in Victoria, 1986-92.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:47 (abstract no. SE4). Unique Identifier : AIDSLINE ASHM5/94348984; Crofts N; Stevenson E; Thompson S; Macfarlane Burnet Centre, Fairfield, Vic.; AIM: To assess trends in age at diagnosis of HIV/AIDS among Victorian gay men METHODS: Geometric mean ages at diagnosis of HIV infection/AIDS were calculated RESULTS: Mean age at diagnosis of AIDS has been consistently about 4.5 years greater than at diagnosis of HIV infection. Both have been increasing steadily over
Length of phases of HIV disease defined by CD4 lymphocyte count.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:47 (abstract no. SE3). Unique Identifier : AIDSLINE ASHM5/94348985; Carlin JB; Clinical Epidemiology & Biostatistics Unit, Royal Children's; Hospital, Melbourne.; OBJECTIVES: To review and synthesize available knowledge on the usual lengths of time spent by persons with HIV in each of the clinically defined phases: (1) CD4 count > 500 (x 10(6)/l), (2) CD4 count 200-500, (3) CD4 count
Controlled evaluation of a brief intervention for HIV prevention among injecting drug users not in treatment.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:48 (abstract no. SE5). Unique Identifier : AIDSLINE ASHM5/94348986; Baker A; Kochan N; Dixon J; Heather N; Wodak A; National Drug and Alcohol Research Centre, Kensington, NSW.; This study evaluated the effectiveness of a brief intervention (BI) in reducing HIV risk-taking behaviours among 200 injecting drug users (IDU) not enrolled in any form of treatment for drug dependence. Subjects were randomly assigned to either a one-session cognitive-behavioural intervention or to a no-treatment cont
Depressive symptoms in patients with HIV infection.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:49 (abstract no. TP2). Unique Identifier : AIDSLINE ASHM5/94348987; Judd FK; Mijch AM; Fairfield Hospital, Melbourne.; OBJECTIVES: To determine the frequency of depressive symptoms and suicidal ideation amongst patients with HIV/AIDS attending an outpatient clinic in suburban Melbourne. METHODS: All patients (unless non-English speaking) attending one physician at Fairfield Hospital over a 4 month period were asked to complete the 21
Psychiatric morbidity in HIV infection.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:49 (abstract no. TP1). Unique Identifier : AIDSLINE ASHM5/94348988; Strain J; The psychiatric morbidities that accompany HIV disorders stem from three sources: 1) the virus impact on the central nervous system; 2) chemotherapeutic agents prescribed for: the virus, other infections, and/or the neoplastic disorders; and, 3) acute psychological reactions to fears of or knowledge of having the dis
Depressive pseudodementia. V. Organic cerebral disease.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:50 (abstract no. TP3). Unique Identifier : AIDSLINE ASHM5/94348989; Cockram AM; Judd FK; Mijch AM; Fairfield Hospital, Melbourne.; A 30 year homosexual man, was referred for assessment of depressed mood. He had recently been an inpatient for treatment of Mycobacterium avium bacteremia, but had responded well to treatment and had returned to full time employment. He described low mood of several months duration, anxiety, sleep disturbance, poor ap
Patterns of AIDS bereavement.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:50 (abstract no. TP4). Unique Identifier : AIDSLINE ASHM5/94348990; Kelly B; Raphael B; Hickman B; Statham D; Ross M; National Centre for HIV Social Research, University of QLD.; AIMS: A prospective study of bereavement following an AIDS death is being conducted, investigating patterns of bereavement response, risk factors to pathological grief and comparison with a group of cancer bereaved individuals. METHOD: 32 AIDS and 41 cancer bereaved subjects (mostly parents and partners/spouse) comple
Coping strategies and psychosocial context of HIV positive young gay men.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:51 (abstract no. FP2). Unique Identifier : AIDSLINE ASHM5/94348991; Goggin M; Centre for the Study of STDs, LaTrobe University, Carlton South.; OBJECTIVE: To examine the strategies young men use in coping with being HIV positive and relate these to the young men s psychosocial context. METHOD: 101 HIV positive young gay men aged 17 to 30 (mean age = 26.0 years) were recruited from non-clinical settings and interviewed about their coping strategies, which are
Personal relationships and HIV/AIDS.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:51 (abstract no. FP1). Unique Identifier : AIDSLINE ASHM5/94348992; O'Loughlin B; Cannold L; Hickman B; McLean S; Woolcock G; AIM: To investigate ramifications of HIV/AIDS upon relationship networks and the role of these relationships in developing meaning and coping mechanisms for living with HIV/AIDS. METHODOLOGY: Semi-structured interviews with fifteen gay men. Thematic content analysis used on transcribed tapes. RESULTS: A significant nu
Constructing a sexual self: sexual self conceptions and their influence on HIV/AIDS risk behaviours.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:52 (abstract no. FP3). Unique Identifier : AIDSLINE ASHM5/94348993; Buzwell S; Centre for the Study of STDs, La Trobe University, Carlton South.; OBJECTIVE: To examine the context in which adolescents make their sexual decisions and how these perceptions impact upon their behaviour, and in particular those behaviours that put adolescents at risk of contracting HIV. METHOD: Questionnaires were administered to 870 adolescents (aged to 15 to 18) attending two Melb
Knowing about AIDS: from information to understanding.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:52 (abstract no. FP4). Unique Identifier : AIDSLINE ASHM5/94348994; Rosenthal D; Centre for the Study of STD, La Trobe University, Carlton South.; OBJECTIVE: To document developmental changes in adolescents knowledge about AIDS. METHOD: Pre-adolescents and adolescents (aged 10 to 18 years) were tested on their knowledge of HIV/AIDS. Knowledge was assessed using a self-report questionnaire (examining levels of factual knowledge) and a semistructured interview (e
HIV, confidentiality and the duty to warn.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:53 (abstract no. SP2). Unique Identifier : AIDSLINE ASHM5/94348995; Ryan C; Department of Psychiatry, Nepean Hospital, Penrith, NSW.; Taking the hypothetical example of an HIV positive dentist who wishes to continue practicing, this paper explores the ethical issues facing a clinician who must decide whether or not to breach confidentiality when others are placed at risk of contracting HIV. In addition the paper explores the common law and statutory
Neuropsychological impairment in AIDS dementia complex (ADC): preliminary results.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:53 (abstract no. SP1). Unique Identifier : AIDSLINE ASHM5/94348996; Dunbar N; Brew B; National Centre in HIV Epidemiology and Clinical Research,; University of New South Wales, Sydney.; AIM: To develop a predictive model of neuropsychological impairment in ADC. METHOD: HIV+ homosexual men were recruited. Eligibility criteria were: CD4+ cell count
Alcoholism as a risk factor.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:54 (abstract no. SP5). Unique Identifier : AIDSLINE ASHM5/94348997; Strain J; Individuals who use alcohol have been found to be at higher risk for HIV infection than those who do not. The San Francisco Gay Men s Health Study, the Multicenter AIDS Cohort Study (MACS), and the Newark Medical Center Alcoholic Assessment Study, all describe that the use of alcohol, and, in particular, if there is a
Counselling for difficult patient.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:54 (abstract no. SP4). Unique Identifier : AIDSLINE ASHM5/94348998; Waters B; Department of Psychiatric Services, St. Vincent's Hospital,; Sydney.; HIV has not afflicted a representative cross section of the community. IDU s have a greatly increased risk of having pre-existing personality disorder and/or unstable interpersonal relationships. HIV+ male homosexuals are more likely than their HIV-counterparts to have a history of prior mental health interventions, p
Bacillary angiomatosis.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:55 (abstract no. FCP1). Unique Identifier : AIDSLINE ASHM5/94348999; Kamarulzaman A; Armes J; Fairfield Infectious Disease Hospital, Victoria.; CASE REPORT: A 28 year old homosexual man with AIDS presented with multiple skin lesions on the dorsum of the foot. A biopsy of one of the lesions revealed histological changes consistent with bacillary angiomatosis . Treatment with erythromycin was instituted which resulted i
Undiagnosed HIV infection presenting with disseminated primary cutaneous nocardiosis in the Northern Territory.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:55 (abstract no. FCP2). Unique Identifier : AIDSLINE ASHM5/94349000; Patel A; Bowden F; Heath T; Fisher D; Currie B; HIV/STD Unit, Communicable Diseases Centre, Casuarina NT.; Nocardia asteroides is a soil saprophyte. Human infection is predominantly acquired by inhalation and is not uncommonly associated with immunosuppression due to therapeutic drugs, haematological malignancy or general debility as occurs with chronic alcoholism. Surprisingly few cases of nocardiosis in HIV infected pati
Disseminated Penicillium marneffei: presenting illness of advanced HIV infection in a Burmese immigrant. Successful treatment with early recognition.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:56 (abstract no. FCP4). Unique Identifier : AIDSLINE ASHM5/94349001; Heath T; Patel A; Fisher D; Currie B; Royal Darwin Hospital, Casuarina NT.; Penicillium marneffei is a dimorphic fungus occasionally causing infection in immunocompetent individuals, but more frequently infecting patients with impaired T-cell immunity, particularly in association with HIV. Infection appears to be confined to residents of, or travellers to, south-east Asia, especially northern
Pyomyositis and HIV: an infrequent yet recognised association.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:56 (abstract no. FCP3). Unique Identifier : AIDSLINE ASHM5/94349002; Hellard ME; Street AC; Royal Melbourne Hospital.; Skeletal muscle abscesses (pyomyositis) are an uncommon but well recognised problem in human immunodeficiency virus (HIV) patients. This report discusses a case of an ileopsoas abscess in an HIV patient and reviews the experience with HIV associated pyomyositis in patients attending the Royal Melbourne & Fairfield
From grim reaper to mainstream.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:57 (abstract no. SSW2). Unique Identifier : AIDSLINE ASHM5/94349003; Hoy KW; Morehead S; From Grim Reaper to mainstreaming of HIV/AIDS services, a contextual analysis of service delivery based on policy documents and strategies in both the local arena and in Australia . The less obvious social work contributions to policy planning and practice applications will be id
The contribution of sociobehavioural research to AIDS prevention and treatment.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:57 (abstract no. SSW1). Unique Identifier : AIDSLINE ASHM5/94349004; Jackson AC; James C; HIV/AIDS Sociobehavioural Research Unit, School of Social Work,; Melbourne University.; This paper illustrates the contribution of sociobehavioural research to the development of HIV/AIDS prevention education programs, and to the development of relevant service models for treatment. It focuses on work undertaken in the HIV/AIDS Sociobehavioural Research Unit at Melbourne University, and presents a range
Issues: infectious diseases service.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:58 (abstract no. SSW3). Unique Identifier : AIDSLINE ASHM5/94349005; O'Connor SP; Infectious Diseases Service, Royal Melbourne Hospital.; In this paper there will be a short case presentation highlighting some of the many issues that may arise when working with a member of this client group. Some ethical issues are outlined and responded to and important points to cover with all users will be outlined. Finally, a suggested framework for facilitating eff
Medically acquired HIV.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:58 (abstract no. SSW4). Unique Identifier : AIDSLINE ASHM5/94349006; Mudge L; Haemophilia Treatment Centre, Alfred Hospital, Prahran.; From 1980-85 approximately 240 people with coagulation disorders were infected with HIV through treatment with blood products. This paper outlines the progression and psychosocial impact on the 60 patients currently treated at the Alfred Hospital for medically acquired HIV. There are particular psychosocial issues rel
AIDS dementia: educational needs of carers.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:59 (abstract no. TPa1). Unique Identifier : AIDSLINE ASHM5/94349007; Grigg M; Fairfield Hospital, Victoria.; Much of the focus on AIDS dementia has concentrated on epidemiological, diagnostic and treatment issues. Another important dimension is the educational needs of carers. Carers often experience a range of difficulties when caring for the person with AIDS dementia. These difficulties
HIV dementia--challenge to services.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:59 (abstract no. TPa2). Unique Identifier : AIDSLINE ASHM5/94349008; Briton C; Fensling L; Watson J; Social Work Department, Fairfield Hospital, Vic.; Every diagnosis of AIDS has repercussions that are widespread as well as deeply felt. AIDS Dementia Complex brings a particularly wide range of issues which are magnified and accentuated when the person is otherwise physically well. The authors look in same detail at personal, social, ethical, legal and practical issu
Pain in patients with advanced AIDS.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:60 (abstract no. SPa2). Unique Identifier : AIDSLINE ASHM5/94349009; Glare P; Palliative Care Service, Royal Prince Alfred Hospital,; Camperdown, NSW.; There has been little systematic evaluation of pain or its treatment in patients with HIV/AIDS. The charts of all HIV admissions to the palliative care ward at Eversleigh Hospital, Petersham were reviewed for pain and analgesic use. There were 104 admissions of 68 patients. 65 (96%) were males. 63 (93%) had stage IV d
What is the best model for AIDS palliative care?: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:60 (abstract no. SPa1). Unique Identifier : AIDSLINE ASHM5/94349010; Malcolm JA; Nineways Specialist Clinic, Broadmeadow, NSW.; In one of competing models AIDS palliation begins when active treatment ceases and responsibility for care passes from a treatment to a palliative care service. This model (based on cancer care) limits service overlap and is economical, but creates practical and ethical difficulty in defining when to cease active trea
In vitro activity of protease inhibitors against HIV.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:62 (abstract no. TB2). Unique Identifier : AIDSLINE ASHM5/94349011; Birch C; Tachedjian G; Tyssen D; Grobelny D; Virology Department, NCHVR, Fairfield, Victoria.; HIV encodes a novel aspartyl protease that represents an important virus-specific target for inhibitors. We have been studying a series of transition state analogue inhibitors designed and synthesised in Australia that have potent and specific activity against HIV replication in
Isolation and zidovudine sensitivity of HIV-1 isolated from post-mortem tissue.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:62 (abstract no. TB1). Unique Identifier : AIDSLINE ASHM5/94349012; McGavin CH; Land SA; Birch CJ; Virology Department, Fairfield Hospital, Victoria.; We attempted to isolate HIV from post-mortem tissues (CSF, spleen, spinal cord, brain and lymph node) of 64 patients. The overall isolation rate was low (48%) compared to a rate of 95% from peripheral blood mononuclear leucocytes (PBMC s) from the same patients when they were alive. This difference appeared to be due
In vitro generation and characterisation of foscarnet-resistant HIV-1.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:63 (abstract no. TB3). Unique Identifier : AIDSLINE ASHM5/94349013; Tachedjian G; Mills J; Birch C; Macfarlane Burnet Centre, Fairfield Hospital, Australia.; Foscarnet (phosphonoformic acid) is a pyrophosphate analogue used for the treatment of CMV retinitis and acyclovir-resistant herpes simplex infections in AIDS patients. Foscarnet is also an inhibitor of HIV, and therefore long-term administration in patients may
Novel mutations associated with HIV-1 resistance to AZT.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:63 (abstract no. TB4). Unique Identifier : AIDSLINE ASHM5/94349014; Hooker DJ; Gurusinghe AD; Land SA; Birch CJ; McGavin C; Tachedjian G; Deacon NJ; AIDS Molecular Biology Lab, NCHVR Macfarlane Burnet Cent. for; Med. Res., Fairfield, Vic.; Associated with AZT therapy is the emergence in patients of drug resistant isolates of HIV-1. Certain mutations observed in the reverse transcriptase (RT) gene/protein upon AZT therapy, namely at codons 41, 67, 70, 215 and 219, have previously been re
Potential molecular competitors for HIV.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:64 (abstract no. TB5). Unique Identifier : AIDSLINE ASHM5/94349015; Pieczenik G; Cook College, Rutgers University, New Brunswick, NJ 08903.; The phenotype of clinically non-pathogenic strains of HIV-1 do not differ dramatically from the clinical picture of pathogenic strain of HIV-1. A differential diagnosis of a clinical infection with a non-pathogenic strain is the observation of infectious hypo virulence. Infectious hypo virulence is an infection of a p
Uptake and expression of HIV-1 B isolated thymic dendritic cells.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:64 (abstract no. TB6). Unique Identifier : AIDSLINE ASHM5/94349016; Lowe M; Sotzic F; Shortman K; Cameron P; Macfarlane Burnet Centre for Medical Research, Fairfield,; Victoria.; Dendritic cells (DC) are the major antigen presenting cells for the induction of T cell mediated immune responses. We have found DC isolated from peripheral blood by sorting are CD4- and do not allow viral entry by T cell or macrophage tropic isolates of HIV-1. DC are functionally and phenotypically heterogeneous and
Factors involved in susceptibility of macrophages but not fresh monocytes to HIV infection.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:65 (abstract no. TB8). Unique Identifier : AIDSLINE ASHM5/94349017; Maerz A; Sonza S; Crowe S; Macfarlane Burnet Centre for Medical Research, Fairfield,; Victoria.; OBJECTIVES: To determine the time post isolation at which monocyte/macrophages show increased susceptibility to infection with HIV, and identify the stage of viral replication which is blocked in cells which are less susceptible. METHODS: Monocytes were isolated from HIV seronegative buffy coats by density gradient ce
Molecular mechanisms of interleukin 4 stimulation of HIV mRNA expression in human monocytes.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:65 (abstract no. TB7). Unique Identifier : AIDSLINE ASHM5/94349018; Naif H; Mathijs JM; Shon MH; Chang J; Cunningham T; Virology Department, Westmead Hospital, National Centre in HIV; Research, Sydney, Australia.; HIV-1 can productively infect mononuclear phagocytes derived from blood bone marrow, brain and lung. Interleukin 4 (IL-4) and tumor necrosis factor alpha (TNF alpha) have previously been shown to stimulate HIV replication in monocytes and macrophages (1,2). The mechanism of IL-4 stimulation was investigated and compar
HIV-1 integration in peripheral blood monocytes and cultured macrophages.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:66 (abstract no. TB9). Unique Identifier : AIDSLINE ASHM5/94349019; Sonza S; Maerz A; Mills J; Crowe S; AIDS Pathogenesis Research Unit, NCHVR, Macfarlane Burnet Centre; for Medical Research, Fairfield, Victoria.; Although integration has been clearly demonstrated in HIV-1 infected lymphocytes, there has been only a single unconvincing report of this in primary macrophages. We have used various polymerase chain reaction-based techniques to determine whether and when this step in the infection process takes place in monocytes an
Twin studies suggest a host cell genetic effect on HIV replication in human monocytes/macrophages.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:66 (abstract no. TB10). Unique Identifier : AIDSLINE ASHM5/94349020; Chang J; Li S; Sullivan J; Kazazi F; Naif H; Cunningham T; Virology Department, Westmead Hospital, National Centre in HIV; Research, Sydney, Australia.; Biological and genetic variability is a prominent feature of HIV strains, especially in tropism, syncytial formation and replicative capacity. Preliminary studies also suggested there were variable host cell effects on HIV replication in monocytes. Therefore we used monocytes from identical (ID) twins and age matched
A cis-acting repressive sequence that overlaps the Rev-responsive element of HIV-1 regulates nuclear retention of env mRNAs independently of splice signals.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:67 (abstract no. FB1). Unique Identifier : AIDSLINE ASHM5/94349021; Brighty DW; Rosenberg M; SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania; 19406-0939.; The Rev protein of HIV-1 binds to an RNA structure, the Rev-Responsive Element (RRE), and enhances expression of the viral structural genes by relieving the nuclear sequestration of incompletely spliced viral transcripts. It has been due to the activity of cis-acting repressive sequence (CRS) elements and to inefficie
Impaired phagocytosis and killing of Toxoplasma gondii by HIV-infected macrophages.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:67 (abstract no. TB11). Unique Identifier : AIDSLINE ASHM5/94349022; Hewish M; Biggs BA; Kent S; Crowe SM; Walter and Eliza Hall Institute of Medical Research.; The protozoan parasite, Toxoplasma gondii, causes asymptomatic but persistent infection in 30-45% of the Australian population, and reactivation of latent infection is a major cause of morbidity and mortality in AIDS patients. Impaired macrophage function during HIV-infection may play a role in allowing reactivation.
Involvement of the c-myb proto-oncogene in HIV-1 gene expression.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:68 (abstract no. FB3). Unique Identifier : AIDSLINE ASHM5/94349023; Churchill MJ; Ramsay RG; Deacon NJ; AIDS Molecular Biology Unit, NCHVR, Macfarlane Burnet Centre,; Parkville, Australia.; Recently it has been shown that the HIV-1 LTR contains a high affinity Myb-binding site, (Dasgupta et al, PNAS 1990; 87:8090). The proto-oncogene c-myb, is expressed in many cell types including hemopoietic cell lines and tissues where it is thought to be associated with the regulation of proliferation and differentia
Mutually dependent, concurrent RNA and DNA synthesis during early phase HIV replication.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:68 (abstract no. FB2). Unique Identifier : AIDSLINE ASHM5/94349024; Kok TW; Li P; Burrell CJ; Div. of Medical Virology, NCHVR, Institute of Medical and; Veterinary Science, Adelaide, South Australia.; In a cell-to-cell HIV infection model it was found that there were two distinct phases of induced HIV RNA synthesis. The first phase (4h - 12h pi) was marked by a significant increase in only the genomic-length viral RNA. The second, phase (24h onwards) comprised a dramatic increase in the levels of all three species
Activation of the NF-kappa-B p105 promoter by HTLV-I Tax.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:69 (abstract no. FB5). Unique Identifier : AIDSLINE ASHM5/94349025; Lambert P; Ludford M; Deacon N; Doherty R; Macfarlane Burnet Centre for Medical Research, Fairfield,; Victoria.; The transactivator protein of HTLV-I, Tax, activates transcription not only from the HTLV-I LTR, but also from several other viral and cellular promoters. One of its targets is the LTR of HIV; HIV replication is enhanced in HTLV-I-infected cell lines, and there is increasing evidence that patients infected with both v
Multiple proteins interact over the USF binding site in the human immunodeficiency virus type 1 long terminal repeat.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:69 (abstract no. FB4). Unique Identifier : AIDSLINE ASHM5/94349026; Tanskanen E; Deacon N; Churchill M; Doherty R; Macfarlane Burnet Centre for Medical Research, Fairfield, Vic.; HIV-1 gene expression and viral replication are regulated by several viral and cellular proteins, most commonly through binding sites within the long terminal repeats (LTRs) of the viral genome. We have examined binding of transcription factors over the region from nt -141 to nt -180 relative to transcription initiati
Double-stranded strong-stop DNA and HIV reverse transcription.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:70 (abstract no. FB7). Unique Identifier : AIDSLINE ASHM5/94349027; Li P; Stephenson A; Kuiper L; Burrell CJ; National Centre for HIV Virology Research, Institute of Medical; and Veterinary Science, Adelaide, South Australia.; Using a synchronized, one-step HIV infection model, we report here the detection in acutely infected cells of a novel double-stranded strong-stop HIV DNA with a discrete length of approximately 650 base pairs, commencing at or near the left hand end of the right hand U3 region of the HIV long terminal repeat. The plus
Reverse transcription factories in cell-to-cell HIV infection.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:70 (abstract no. FB6). Unique Identifier : AIDSLINE ASHM5/94349028; Karageorgos LE; Li P; Burrell CJ; National Centre for HIV Virology Research, Institute of Medical; and Veterinary Science, Adelaide, South Australia.; Reverse transcription, the conversion of the single-stranded RNA genome into double-stranded DNA molecule, is a major event in the life cycle of retroviruses. We have shown that full-length unintegrated viral DNA in the cytoplasm of HIV infected cells is found in association with the viral proteins reverse transcripta
Analysis of HIV-induced apoptosis: viral infection is required.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:71 (abstract no. SB1). Unique Identifier : AIDSLINE ASHM5/94349029; Corbeil J; Howell ML; Richman DD; University of California San Diego, Department of Pathology, La; Jolla 92093-0679.; Lymphoblastoid T cell lines (SupTl, MT-2 and WE 17/10) and preparations of peripheral blood lymphocytes (CD4+ T cells enriched to 90%) were exposed to HIV-1LAI either untreated or inactivated with 4 -aminomethyltrioxsalen (10 approximately g/mL) in combination with long-wave-length ultraviolet light (320-400nm) to ren
HIV-1 auxiliary protein Nef down-regulates expression of cellular receptors and factors involved in signalling.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:71 (abstract no. SB2). Unique Identifier : AIDSLINE ASHM5/94349030; Greenway A; Allen K; McPhee D; AIDS Cellular Biology Unit, Macfarlane Burnet Centre, NCHVR,; Melbourne, Victoria, Australia.; The function of HIV-1 Nef protein, although poorly understood, has been implicated in the progression of HIV infection to AIDS. To address the effect of Nef on cellular activity, Nef protein was introduced into cells by a sophisticated electroporation technique. Electroporation of HIV-1 Nef reduced the expression of c
HIV-1 grown in CD4-bearing cells may be coated with CD4.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:72 (abstract no. SB4). Unique Identifier : AIDSLINE ASHM5/94349031; Hartley C; Gilbert M; Elbeik T; Crowe S; Mills J; Macfarlane Burnet Centre for Medical Research, Fairfield,; Victoria.; Using a CD4-capture enzyme-immunoassay, HIV-1 (SF33) grown in CD4-expressing T-lymphoblastoid cells (SF33-VB) were found to contain 100-10,000 fold less reactive gp 120 than HIV-1 (SF33) grown in CD4-negative human neuroblastoma cell (SF33-NB), despite similar virus titres. Virus strains grown in CD4-expressing cells
Surface protein analysis of a non-syncytium inducing HIV-1 isolate.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:72 (abstract no. SB3). Unique Identifier : AIDSLINE ASHM5/94349032; Fryer KM; Deacon NJ; Land SA; McPhee DA; Macfarlane Burnet Centre for Medical Research, Fairfield, Vic.; An Australian HIV-1 isolate that is non-syncytium inducing (NSI), and has reduced cytopathic effect on peripheral blood mononuclear cells (PBMCs) has been characterised. The biochemical properties and DNA sequence of this isolate (243925) were compared with a typical syncytium inducing (SI) isolate 228200. Both isolat
Effects of GMCSF and HIV-1 infection on the expression of CD11a on monocyte-derived macrophages.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:73 (abstract no. SB5). Unique Identifier : AIDSLINE ASHM5/94349033; Stent G; Crowe SM; Macfarlane Burnet Centre for Medical Research, Fairfield,; Australia.; OBJECTIVES: To examine the kinetics and regulation of CD11a on monocytes (MO) and macrophages (Mphi). METHODS: Mphi were isolated from buffy coats (n = 4) by density gradient centrifugation and plastic adherence or elutriation. (1) MO were incubated with varying concentrations of GMCSF (0-500U/ml) on the day of isolat
Production of HIV DNA, mRNA and protein without infectious virus in growth-arrested cells.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:73 (abstract no. SB6). Unique Identifier : AIDSLINE ASHM5/94349034; Kiernan R; Purcell D; McPhee D; National Centre in HIV Virology Research, Cellular Biology Unit,; Macfarlane Burnet Centre for Medical Research, Fairfield, Vic.; We have previously shown that an HTLV-I transformed cell line, MT-2, arrested in cell division and proliferation by treatment with 5 mM hydroxyurea could not be productively infected by HIV. Both release of cell-free virus and cell-cell fusion were found to be inhibited. Step-wise analyses of HIV replication have show
Fried green pentamidine at the Carlton Clinic Cafe. Nurse practitioners, HIV infection and private general practice: the way of the future?: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:74 (poster no. 1). Unique Identifier : AIDSLINE ASHM5/94349035; Mitchell J; Bradford D; Russell D; Murray P; Carlton Clinic, Vic, Australia.; OBJECTIVES: To investigate the possible role of a nurse counsellor (NC) in improving cost effective service delivery for HIV-positive patients in the private general practice setting. METHODS: A NC was employed under a GP demonstration practice grant by the Commonwealth Department of Health for 6 months in an establis
Who calls the Sydney HIV/AIDS Information Line?: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:74 (poster no. 2). Unique Identifier : AIDSLINE ASHM5/94349036; Harvey-Sutton P; Nelson M; Tomkins M; Albion St. Centre, Surry Hills.; Since its inception in 1985 the NSW HIV/AIDS Information Line receives an average of 100 calls per day from which statistics are gathered about the caller s sex, location, sexuality, transmission issues, risk behaviour, nature of enquiry, and referral/action taken. These statistics can be used to assess areas of HIV e
Occupational therapy and working with people with HIV/AIDS.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:75 (poster no. 4). Unique Identifier : AIDSLINE ASHM5/94349037; Jackson M; Black K; Taylor K; Nicholas S; Community Health Services, Central and Eastern Sydney Area; Health.; Discussion of various topics including: 1. The changing role of occupational therapy (O.T.) in HIV/AIDS to less traditional areas. 2. O.T. treatment and intervention in AIDS related illness. 3. Issues of energy conservation and fatigue management. 4. The role of stress management and meditation. 5. Issues of home rese
Physiotherapy: enhancing primary care & improving quality of life.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:75 (poster no. 3). Unique Identifier : AIDSLINE ASHM5/94349038; Zacka M; Physiotherapy Dept. Royal Prince Alfred Hospital, Camperdown,; NSW.; The physiotherapist is integral to the multidisciplinary team working in HIV. The role of the physiotherapist is often poorly understood and therefore frequently under utilised. The physiotherapist offers intervention in the following areas: 1. Respiratory disorders. Obtaining sputum specimens, treatment of pneumonias
HIV counselling training for general practitioners.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:77 (poster no. 8). Unique Identifier : AIDSLINE ASHM5/94349039; Lipp J; Stynes R; Jackson S; Catter L; Moloney B; Phillips G; Anita Morawetz HIV Counselling and Training Centre (A.M. Centre),; Parkville.; OBJECTIVES: To train general practitioners in counselling skills as an essential component of their ongoing management of HIV patients in a community setting. METHODS: A state-funded training program in HIV counselling has been run by the A.M. Centre for the past 3 years. This is a one year, half day/week course open
Undergraduate education in HIV medicine.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:77 (poster no. 7). Unique Identifier : AIDSLINE ASHM5/94349040; Cross G; Savage J; Department of Microbiology, Monash Medical School, Alfred; Hospital, Prahran, Vic.; In 1992, an elective programme was introduced into the undergraduate medical curriculum at Monash University. This programme An Introduction to HIV Medicine aimed to provide a broader view than that provided by ward-based clinical teaching. It included perspectives from general practice, counsellors, people living w
Design and implementation of a general practitioner program for the prevention and treatment of HIV infection.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:78 (poster no. 9). Unique Identifier : AIDSLINE ASHM5/94349041; McCoy R; Mijch A; Grierson J; Perry G; Fairfield Hospital, Melbourne Australia.; OBJECTIVES: To increase the number of general practitioners able to successfully manage HIV patients in a community setting. METHODS: A state-funded education program was designed by a multidisciplinary team consisting of medical specialists, general practitioners, people with HIV infection and a range of HIV/AIDS edu
The management and prevention of HIV in the rural setting: Eaglehawk Health Centre.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:78 (poster no. 10). Unique Identifier : AIDSLINE ASHM5/94349042; Hajicosta T; Duke R; Eaglehawk and Long Gully Community Health Centre, Bendigo,; Victoria, Australia.; OBJECTIVES: To improve the prevention of HIV and establish treatment services for people with HIV infection in the Bendigo Region. METHODS: Six general practitioners, two nurses, one social worker, from Eaglehawk Health Centre 150km north of Melbourne Victoria participated in incorporating the management of HIV infect
Multicultural HIV/AIDS: a model of care.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:79 (poster no. 12). Unique Identifier : AIDSLINE ASHM5/94349043; Todaro P; Eisenberg M; Multicultural HIV/AIDS Education and Support Project, Camperdown,; NSW.; The Multicultural HIV/AIDS Education and Support Project was established in May 1991. The Project is funded by the AIDS Bureau, NSW Department of Health, and is auspiced by the Central Sydney Area Health Service. It targets 15 non-English speaking communities (identified by the AIDS Bureau). The Multicultural HIV/AIDS
The HIV/AIDS anti-discrimination campaign: was it news?: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:79 (poster no. 11). Unique Identifier : AIDSLINE ASHM5/94349044; Bell GK; Albion Street Centre, Surry Hills.; OBJECTIVES: To examine the response of the major metropolitan newspapers to the Federal Government s HIV/AIDS Anti-discrimination campaign in January, 1993; to explore current attitudes in the media towards AIDS. METHODS: Interviews with journalists involved in writing about the campaign and with members of the Austra
Hypermedia and HIV/AIDS education for medical students and general practitioners.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:80 (poster no. 14). Unique Identifier : AIDSLINE ASHM5/94349045; Kidd M; Bearman M; Cesnik B; Turnidge J; McCoy R; Unit of Medical Informatics, Monash University, East Bentleigh,; Australia.; This oral presentation will outline the development and evaluation of a major hypermedia education package on the management and prevention of HIV/AIDS. The HIV Hypermedia Medical Education Project has been created to provide a comprehensive computer based teaching program for Australian medical students and general p
The HIV Hypermedia Medical Education Project.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:80 (poster no. 13). Unique Identifier : AIDSLINE ASHM5/94349046; Bearman M; Kidd M; Cesnik B; Turnidae J; McCoy R; Unit of Medical Informatics, Monash University, East Bentleigh,; Australia.; This is an interactive computer based poster demonstration. It provides conference participants with the opportunity to engage in a hands on exploration of this richly linked hypertext program and its exciting multimedia components. The HIV Hypermedia Medical Education Project has been created to provide a comprehensi
Attitudes, beliefs and knowledge about HIV.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:81 (poster no. 15). Unique Identifier : AIDSLINE ASHM5/94349047; Carman J; Roth N; Ross M; Painter L; HIV/AIDS Services, Camperdown, NSW.; The Central Sydney Area Health Service (CSAHS) of Sydney comprises several hospitals, community care centres and nursing homes. A questionnaire was administered to one fifth of all of the employees of the CSAHS, investigating their attitudes, beliefs and knowledge about HIV/AIDS. 1,056 responses were obtained. The dat
Health strategies of HIV-infected, homosexually-active men in Sydney, Australia: implications for health care workers.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:81 (poster no. 16). Unique Identifier : AIDSLINE ASHM5/94349048; Ariss R; Carriqan T; Dowsett G; National Centre for HIV Social Research, Macquarie University,; Sydney, Australia.; AIM: To map the socio/cultural determinants of the health strategies adopted by HIV positive, homosexually-active men. METHOD: From an existing cohort of 535 men (Social Aspects of the Prevention of AIDS, 1987), 10 HIV positive homosexually-active men were selected to explore responses to HIV infection. The study empl
Design and implementation of a program to educate doctors and health care providers about living with HIV/AIDS by people living with HIV/AIDS.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:82 (poster no. 17). Unique Identifier : AIDSLINE ASHM5/94349049; Hillier J; McKenzie J; Victorian AIDS Council, Collingwood, Aus.; OBJECTIVES: To increase the awareness of doctors and health care providers about living with HIV/AIDS through the personal experiences of People Living With HIV/AIDS. METHODS: People with HIV/AIDS discuss their personal experiences with groups of doctors and other health care providers to convey appropriate and inappr
HIV/AIDS grief, loss & bereavement: community response.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:83 (poster no. 18). Unique Identifier : AIDSLINE ASHM5/94349050; Raphael B; Woolcock G; OBJECTIVE: To improve understanding and knowledge of the social and psychological aspects of grief and loss associated with HIV/AIDS within AIDS organisations. METHOD: One of the recommendations from a National Centre HIV/AIDS grief and loss colloquium was to review policies and programs within AIDS organisations with
Psychoimmunology and the Wellness Programme.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:84 (poster no. 20). Unique Identifier : AIDSLINE ASHM5/94349051; Rayner-Brosnan DP; At the National Centre for HIV Social Research and within The Wellness Programme, a model has been developed that points to specific psychobehavioural factors for the HIV positive person that have immune consequences. A prospective longitudinal study is now underway to increase current knowledge about those aspects wi
Contexts of unsafe sex among non-homosexually-identified men.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:85 (poster no. 21). Unique Identifier : AIDSLINE ASHM5/94349052; Crawford J; Prestage G; Hood D; Kippax S; Sorrell T; National Centre for HIV Social Research, Macquarie Unit,; Macquarie University, NSW.; OBJECTIVES: Identification of some contextual factors associated with unprotected anal intercourse. METHOD AND SAMPLE: Two volunteer samples were interviewed by telephone. One (Project Male-Call) in May-June 1992 with 2583 men nationwide who had had male-to-male sex during the preceding five years. A further 3906 non
Sentinel HIV surveillance in STD Clinics in Australia. Collaborative Group on Sentinel HIV Surveillance in STD Clinics.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:85 (poster no. 22). Unique Identifier : AIDSLINE ASHM5/94349053; McDonald A; Kaldor J; National Centre in HIV Epidemiology and Clinical Research,; Sydney, Australia.; OBJECTIVE: To describe the pattern of HIV antibody testing and newly diagnosed HIV infection among people seen at public sexually transmissible disease (STD) clinics in Australia . METHODS: Each quarter, six STD clinics forwarded tabulations of the number of people seen, the numb
Epidemiology of Qld HIV and AIDS patients.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:86 (poster no. 23). Unique Identifier : AIDSLINE ASHM5/94349054; Magon H; Ree GH; Kennedy J; Cornell V; AIDS Medical Unit, Brisbane.; Long term patient HIV data was divided into 3 groups based on their current CD4 count. The results survey the epidemiological differences between groups and focus on differences between current and initial CD4 levels. Little data has been published on CD4 counts. Surveying Qld patients diagnosed with AIDS post 1/1/89
High risk sexual behaviour of socio-economically disadvantaged youth.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:86 (poster no. 24). Unique Identifier : AIDSLINE ASHM5/94349055; Donald M; National Centre for HIV Social Research, Royal Brisbane Hospital,; Herston, Qld.; Poverty and culture are important determinants of condom use and socio-economic factors are linked to STDs in adolescents. The aim of the study is to investigate disadvantaged youths risk for HIV, STDs and unwanted pregnancies and to ascertain the critical behavioural and psychosocial determinants of high risk sexual
Epidemiology of HIV infection seen at the Royal Adelaide Hospital, 1985-1993.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:87 (poster no. 26). Unique Identifier : AIDSLINE ASHM5/94349056; Wells R; Waddell R; Shaw D; Department of Infectious Diseases, Royal Adelaide Hospital, North; Terrace, SA.; Between 1985 and May 1993, 297 patients infected with HIV have been treated by the infectious diseases department of the Royal Adelaide Hospital, 110 patients had AIDS defining illnesses and 75 died. The characteristics of this population were studied, including age, degree of immunosuppression at presentation to the
Provision of needles and syringes to injecting drug users (IDU) from pharmacies in Victoria.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:87 (poster no. 25). Unique Identifier : AIDSLINE ASHM5/94349057; Mathews G; Batchelor M; Carswell P; Marcon N; Department of Health and Community Services Public Health Branch,; Health Protection, AIDS/STD Unit, Melbourne, Victoria.; Both the Victorian Needle and Syringe Exchange Program (NSEP) and Pharmacy Program provide sterile injecting equipment to Injecting Drug Users (IDU). The broad aim of the program is to prevent the transmission of HIV amongst IDU and from IDU to the broader community. Although the NSEP has been successful in reaching a
Lifestyles and sexual behaviours of non gay attached homosexually active working class men in Western Sydney.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:88 (poster no. 28). Unique Identifier : AIDSLINE ASHM5/94349058; Hood D; Millan G; O'Reilly C; Ramsay J; Western Sydney AIDS Unit, Parramatta Health Service Cnr, NSW.; Western Sydney is the largest sector of the city of Sydney comprising an extensive industrial base and dormitory suburbs of 1.3 million people of diverse socio-economic status. The 1989 Western Sydney Beats Study established that there was an active network of illicit public sex venues known as beats . In that survey6
Modelling the HIV epidemic, results from a three year project.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:88 (poster no. 27). Unique Identifier : AIDSLINE ASHM5/94349059; Kault D; Dept. Maths & Stats, James Cook University, Townsville, Qld.; HIV spreads through a network of sexual contacts. Sexual behaviour surveys give insufficient information about this network to allow predictions of the spread of HIV. However, this information is encoded in the detailed epidemiology of other STDs as these have spread through the same network now available for HIV. Mat6
Human immunodeficiency virus antibody testing at the Gay Men's Health Centre. Melbourne.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:89 (poster no. 29). Unique Identifier : AIDSLINE ASHM5/94349060; Carmody C; Royal Prince Alfred Hospital, Camperdown, Sydney.; BACKGROUND: The Gay Men s Health Centre is a significant testing centre for gay men in Victoria, requesting over 600 Human Immunodeficiency Virus (HIV) antibody tests annually. OBJECTIVES: To determine the number of new diagnoses of HIV infection at the Centre and to obtain epidemiological information on those individ6
HIV antibody testing and HIV risk behaviour among clients attending methadone clinics in NSW.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:89 (poster no. 30). Unique Identifier : AIDSLINE ASHM5/94349061; MacDonald M; Elford J; Wodak A; Ward P; Kaldor J; National Centre in HIV Epidemiology and Clinical Research,; Darlinghurst, NSW.; OBJECTIVE: To describe HIV antibody testing policy and practice, and information collected concerning HIV risk behaviour among clients attending methadone clinics in NSW. METHODS: In April 1993, questionnaires concerning HIV testing policy and practice, and the information collected on HIV risk behaviour, were sent to6
Factitious AIDS.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:90 (poster no. 31a). Unique Identifier : AIDSLINE ASHM5/94349062; Munckhof WJ; Jenkins K; Fairfield Hospital, Vic.; A 19 year old homosexual man was admitted to a general hospital with 3 weeks sweats and cough with haemoptysis. He stated that HIV serology performed one year earlier was positive, and claimed to have pulmonary tuberculosis treated with isoniazid. Physical examination and chest X-ray were normal. Mantoux test was nega6
Trend analysis & back-protection analysis of Qld HIV data.: Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:90 (poster no. 31). Unique Identifier : AIDSLINE ASHM5/94349063; Magon H; Ree GH; Kennedy J; Cornell V; AIDS Medical Unit, Brisbane.; Two widely popular methods for predicting the future incidence of AIDS cases were applied to the Queensland HIV database. Trend analysis gave high to low estimates of AIDS cases & deaths. Estimated new AIDS cases over the three year period 1993 to 1995 ranged from 258 to 348 with AIDS deaths ranging from 184 to 276
Cytomegalovirus in prostates of AIDS patients.: Annu Conf Australas Soc HIV Med. 1993 O