1999
- Elevation of serum cardiac troponin I in noncardiac and cardiac diseases other than acute coronary syndromes.
- Am J Emerg Med. 1999 May;17(3):225-9. Unique Identifier : AIDSLINE MED/99268197
- Khan IA; Tun A; Wattanasauwan N; Win MT; Hla TA; Hussain A; Vasavada BC; Sacchi TJ; Department of Medicine, Long Island College Hospital, Brooklyn,; NY, USA.
- This study evaluated the role of serum cardiac troponin I as a biochemical marker for the diagnosis of acute coronary syndromes in the presence of noncardiac diseases. Diagnostic characteristics were examined in 102 consecutive patients who were found to have serum cardiac troponin I levels higher than the upper refer
- Cytotoxic T-lymphocyte responses to HIV-1 reverse transcriptase (review).
- Viral Immunol. 1998;11(4):167-81. Unique Identifier : AIDSLINE MED/99203068
- Menendez-Arias L; Mas A; Domingo E; Centro de Biologia Molecular "Severo Ochoa", CSIC-Universidad; Autonoma de Madrid, Cantoblanco, Spain.
- Cytotoxic T lymphocytes (CTL) play an important role in the control of human immunodeficiency virus (HIV) infection. CTL responses have been demonstrated for most of the HIV gene products, predominantly gag, pol, and env-encoded proteins, and also for the regulatory proteins Nef, Tat, Vif, or Rev. The HIV-1 reverse tr
- Distinct serum cytokines in AIDS-related skin diseases.
- Viral Immunol. 1998;11(4):215-20. Unique Identifier : AIDSLINE MED/99203071
- Breuer-McHam JN; Marshall GD; Lewis DE; Duvic M; Department of Dermatology, The University of Texas Medical; School, Houston, USA.
- To determine whether common skin diseases associated with human immunodeficiency virus (HIV) were distinguishable based on the pattern of serum cytokine expression, we studied patients with psoriasis, pruritus, and Kaposi s sarcoma (KS) for levels of tumor necrosis factor (TNF)-alpha, interferon-gamma (IFN-y), interle
- Morphine effects on HTLV-I infection in the presence or absence of concurrent HIV-1 infection.
- DNA Cell Biol. 1999 Apr;18(4):285-91. Unique Identifier : AIDSLINE MED/99249190
- Nyland SB; Specter S; Ugen KE; Department of Medical Microbiology and Immunology, University of; South Florida College of Medicine, Tampa 33612, USA.
- Human T-cell leukemia virus type I (HTLV-I) infection is emerging as an important complication in HIV infection and AIDS in injecting drug users. HIV-1 and HTLV-I share a common host in CD4+ T lymphocytes. However, the result of HIV-1 infection is the decimation of this cell population, whereas a hallmark of HTLV-I in
- Impact of drug resistance mutations on virologic response to salvage therapy. Swiss HIV Cohort Study.
- Unique Identifier : AIDSLINE MED/99217469
- Lorenzi P; Opravil M; Hirschel B; Chave JP; Furrer HJ; Sax H; Perneger TV; Perrin L; Kaiser L; Yerly S
- OBJECTIVE: To assess the prognostic significance of
- Virologic responses to a ritonavir--saquinavir-containing regimen in patients who had previously failed nelfinavir.
- AIDS. 1999 Feb 4;13(2):F23-8. Unique Identifier : AIDSLINE MED/99217470
- Tebas P; Patick AK; Kane EM; Klebert MK; Simpson JH; Erice A; Powderly WG; Henry K; Department of Medicine Washington University, St Louis, Missouri; 63108, USA.
- OBJECTIVES: The effectiveness of a second protease inhibitor in patients who failed an initial protease inhibitor is unclear but believed to be low. It has been postulated, however, that patients who fail nelfinavir may respond differently. We therefore assessed the virologic response to a ritonavir-saquinavir-contain
- Place of antiretroviral drugs in the treatment of HIV-infected people in Africa. International AIDS Society.
- AIDS. 1999 Feb 4;13(2):IAS1-3. Unique Identifier : AIDSLINE MED/99217496
- Sexual transmission of HIV: infectiousness and prevention.
- AIDS. 1999 Feb 4;13(2):155-66. Unique Identifier : AIDSLINE MED/99217471
- Vernazza PL; Eron JJ; Fiscus SA; Cohen MS; Department of Medicine and Institute for Clinical Microbiology,; Kantonsspital, St. Gallen, Switzerland.
- Differential expression profiles of apoptosis-affecting genes in HIV-infected cell lines and patient T cells.
- AIDS. 1999 Feb 4;13(2):167-75. Unique Identifier : AIDSLINE MED/99217472
- Scheuring UJ; Sabzevari H; Corbeil J; Theofilopoulos AN; The Scripps Research Institute, Department of Immunology, La; Jolla, CA 92037, USA.
- OBJECTIVE: To clarify the molecular mechanisms of HIV-induced apoptosis. DESIGN: The assessment of expression patterns for genes affecting the interrelated cell cycle and apoptosis processes in HIV-1LAI-infected T lymph oblastoid (CEM) cells, as well as CD4 and CD8 cells from HIV-infected individuals and controls. MET
- Immunopathology as a result of highly active antiretroviral therapy in HIV-1-infected patients.
- AIDS. 1999 Feb 4;13(2):177-84. Unique Identifier : AIDSLINE MED/99217473
- Foudraine NA; Hovenkamp E; Notermans DW; Meenhorst PL; Klein MR; Lange JM; Miedema F; Reiss P; National AIDS Therapy Evaluation Center, Department of Internal; Medicine, Academic Medical Center, University of Amsterdam, The; Netherlands.
- OBJECTIVE: Unusual clinical inflammatory syndromes associated with underlying previously unrecognized opportunistic infections are increasingly being noted shortly after starting highly active antiretroviral therapy (HAART). This study examined the possible relationship between such unexpected disease manifestations a
- Persistent alterations in T-cell repertoire, cytokine and chemokine receptor gene expression after 1 year of highly active antiretroviral therapy.
- AIDS. 1999 Feb 4;13(2):185-94. Unique Identifier : AIDSLINE MED/99217474
- Martinon F; Michelet C; Peguillet I; Taoufik Y; Lefebvre P; Goujard C; Guillet JG; Delfraissy JF; Lantz O; ICGM-INSERM U445, Hopital Cochin, Paris, France.
- OBJECTIVES: To examine T-cell repertoire modifications, the evolution of T-helper (TH)1/TH2 cytokine imbalance and modifications in chemokine receptor expression when the viral load is decreased by 2-3 log10 copies/ml under highly active antiretroviral therapy (HAART). DESIGN: Sixteen patients previously treated with
- CD4+ and CD8+ lymphocytes and HIV RNA in HIV infection: high baseline counts and in particular rapid decrease of CD8+ lymphocytes predict AIDS.
- AIDS. 1999 Feb 4;13(2):195-201. Unique Identifier : AIDSLINE MED/99217475
- Kvale D; Aukrust P; Osnes K; Muller F; Froland SS; Medical Department A and Research Institute for Internal; Medicine, The National Hospital, Oslo, Norway.; dag.kvale@klinmed.uio.no
- OBJECTIVE: To study the progression of HIV infection in relation to immunological and virological variables with emphasis on the role of CD8+ lymphocytes. DESIGN: Prospective follow-up from October 1991 of patients observed for at least 18 months allowing nucleoside analogue monotherapy. Peripheral CD4+ and CD8+ lymph
- Immune restoration does not invariably occur following long-term HIV-1 suppression during antiretroviral therapy. INCAS Study Group.
- AIDS. 1999 Feb 4;13(2):203-12. Unique Identifier : AIDSLINE MED/99217476
- Pakker NG; Kroon ED; Roos MT; Otto SA; Hall D; Wit FW; Hamann D; van der Ende ME; Claessen FA; Kauffmann RH; Koopmans PP; Kroon FP; ten Napel CH; Sprenger HG; Weigel HM; Montaner JS; Lange JM; Reiss P; Schellekens PT; Miedema F; Department of Clinical Viro-Immunology, CLB, Sanquin Blood Supply; Foundation, University of Amsterdam, The Netherlands.
- BACKGROUND: Current antiretroviral treatment can induce significant and sustained virological and immunological responses in HIV-1-infected persons over at least the short- to mid-term. OBJECTIVES: In this study, long-term immune reconstitution was investigated during highly active antiretroviral therapy. METHODS: Pat
- Ritonavir and saquinavir combination therapy for the treatment of HIV infection.
- Unique Identifier : AIDSLINE MED/99217477
- Cameron DW; Japour AJ; Xu Y; Hsu A; Mellors J; Farthing C; Cohen C
- Stavudine in zidovudine (ZDV)-experienced compared with ZDV-naive patients.
- AIDS. 1999 Feb 4;13(2):225-9. Unique Identifier : AIDSLINE MED/99217478
- Gallant JE; Chaisson RE; Keruly JC; Moore RD; Johns Hopkins University School of Medicine, Baltimore, Maryland; 21205, USA.
- OBJECTIVE: To assess the effect of prior zidovudine (ZDV) use on subsequent response to stavudine (D4T)-containing regimens. DESIGN: Analysis of data from prospective observational database. METHODS: Patients were ZDV-experienced if they had previousl
- Short-term progressive resistance training increases strength and lean body mass in adults infected with human immunodeficiency virus.
- AIDS. 1999 Feb 4;13(2):231-9. Unique Identifier : AIDSLINE MED/99217479
- Roubenoff R; McDermott A; Weiss L; Suri J; Wood M; Bloch R; Gorbach S; Department of Community Health, Tufts University School of; Medicine, Jean Mayer USDA Human Nutrition Research Center on; Aging at Tufts University, Boston, MA 02111, USA.; roubenoff@hnrc.tufts.edu
- BACKGROUND: To assess the efficacy of progressive resistance training (PRT) in increasing strength and lean body mass (LBM) in HIV-infected adults. METHODS: Twenty-five adults with HIV infection were trained using a highly intensive PRT regimen for 8 weeks, followed by an additional 8 weeks of observation under ad lib
- Monitoring changes in fat-free mass in HIV-positive men with hypotestosteronemia and AIDS wasting syndrome treated with gonadal hormone replacement therapy [see comments]
- AIDS. 1999 Feb 4;13(2):241-8. Unique Identifier : AIDSLINE MED/99217480
- Van Loan MD; Strawford A; Jacob M; Hellerstein M; US Department of Agriculture, Western Human Nutrition Research; Center, Presidio of San Francisco, California 94129, USA.
- OBJECTIVE: To compare methods for assessing changes in body composition during gonadal hormone replacement therapy in a group of HIV-positive men with AIDS wasting syndrome. DESIGN: The study included a 21-day, double-blind, randomized, placebo-controlled inpatient intervention and a 12-week open-label intervention. T
- Increasing survival time after AIDS in Italy: the role of new combination antiretroviral therapies. Tuscany AIDS Study Group.
- AIDS. 1999 Feb 4;13(2):249-55. Unique Identifier : AIDSLINE MED/99217481
- Pezzotti P; Napoli PA; Acciai S; Boros S; Urciuoli R; Lazzeri V; Rezza G; Centro Operativo AIDS, Istituto Superiore di Sanita, Rome,; Italy.
- BACKGROUND: In Italy , antiretroviral combination therapy was adopted in mid-1995 and protease inhibitors in mid-1996. OBJECTIVE: To conduct a prospective, population-based, observa
- A prospective study of HIV disease progression in female and male drug users.
- AIDS. 1999 Feb 4;13(2):257-62. Unique Identifier : AIDSLINE MED/99217482
- Webber MP; Schoenbaum EE; Gourevitch MN; Buono D; Klein RS; Department of Epidemiology and Social Medicine, Montefiore; Medical Center and the Albert Einstein College of Medicine,; Bronx, New York 10467, USA.
- OBJECTIVE: To compare HIV disease progression and mortality in a cohort of female and male drug users. DESIGN: A prospective cohort study of 222 HIV-seropositive women and 302 HIV-seropositive men who attended a hospital-affiliated methadone maintenance program with on-site primary care. METHODS: Regression slopes of
- AIDS diagnoses at higher CD4 counts in Australia following the introduction of highly active antiretroviral treatment.
- AIDS. 1999 Feb 4;13(2):263-9. Unique Identifier : AIDSLINE MED/99217483
- Law MG; de Winter L; McDonald A; Cooper DA; Kaldor JM; National Centre in HIV Epidemiology and Clinical Research,; University of New South Wales, Darlinghurst, Australia.; mlaw@nchecr.unsw.edu.au
- OBJECTIVES: To assess whether AIDS cases in Australia have been diagnosed at higher CD4 counts since the widespread availability of highly active antiretroviral treatment (HAART) in mid-1996. METHODS: Data on the CD4 count at AIDS diagnosis for AIDS cases diagnosed between 1 Jan
- Selective versus universal antenatal HIV testing: epidemiological and implementational factors in policy choice.
- AIDS. 1999 Feb 4;13(2):271-8. Unique Identifier : AIDSLINE MED/99217484
- Ades AE; Gupta R; Gibb DM; Duong T; Nicoll A; Goldberg D; Stephenson J; Copas A; Department of Epidemiology and Public Health, Institute of Child; Health, London, UK.
- OBJECTIVE: To develop an epidemiological basis for economic analyses of selective and universal antenatal screening strategies, and to apply it to the UK. METHODS: The prevalence of higher-risk women and the prevalence of undiagnosed infection within groups of high-risk and low-risk women was estimated from surveillan
- The impact of body composition analysis in HIV-infected patients: quantifying therapeutic effects [editorial; comment]
- AIDS. 1999 Feb 4;13(2):279-80. Unique Identifier : AIDSLINE MED/99217485
- Ockenga J; Manns MP
- Formation and release of virus-like particles by HIV-1 matrix protein [letter]
- AIDS. 1999 Feb 4;13(2):281-3. Unique Identifier : AIDSLINE MED/99217486
- Wang JJ; Horton R; Varthakavi V; Spearman P; Ratner L
- Potential interaction of antiretroviral therapy with paclitaxel in patients with AIDS-related Kaposi's sarcoma [letter]
- AIDS. 1999 Feb 4;13(2):283-4. Unique Identifier : AIDSLINE MED/99217487
- Schwartz JD; Howard W; Scadden DT
- Drug interaction of isotretinoin and protease inhibitors: support for the cellular retinoic acid-binding protein-1 theory of lipodystrophy? [letter]
- AIDS. 1999 Feb 4;13(2):284-5. Unique Identifier : AIDSLINE MED/99217488
- Padberg J; Schurmann D; Grobusch M; Bergmann F
- Combined stavudine and lamivudine during pregnancy [letter]
- AIDS. 1999 Feb 4;13(2):285. Unique Identifier : AIDSLINE MED/99217489
- Ristola M; Salo E; Ammala P; Suni J
- Impact of Kaposi's sarcoma on HIV disease progression [letter]
- AIDS. 1999 Feb 4;13(2):286. Unique Identifier : AIDSLINE MED/99217490
- Mocroft A; Sabin C; Phillips AN
- HIV-1 subtypes and plasma RNA quantification [letter]
- AIDS. 1999 Feb 4;13(2):286-8. Unique Identifier : AIDSLINE MED/99217491
- Damond F; Apetrei C; Descamps D; Brun-Vezinet F; Simon F
- RANTES upregulation by HIV-1-infected cells: lack of correlation with viral replication and induction of interferon [letter]
- AIDS. 1999 Feb 4;13(2):288-90. Unique Identifier : AIDSLINE MED/99217492
- Abbate I; Carletti F; Dianzani F; Capobianchi MR
- Small differences in CD4+ T-cell production may go unnoticed [letter]
- AIDS. 1999 Feb 4;13(2):290-1. Unique Identifier : AIDSLINE MED/99217493
- Shapiro HM; Lederman M; Connick E; Kessler H; Kuritzkes DR; Landay AL
- Impact of highly active antiretroviral therapy on clinical evolution of genital warts in HIV-infected patients [letter]
- AIDS. 1999 Feb 4;13(2):291-3. Unique Identifier : AIDSLINE MED/99217494
- Orlando G; Fasolo MM; Signori R; Schiavini M; Casella A; Cargnel A
- Prevalence and underestimation of pain in HIV-infected patients by physicians: a cross-sectional study in a day care hospital [letter]
- AIDS. 1999 Feb 4;13(2):293-5. Unique Identifier : AIDSLINE MED/99217495
- Bernard N; Spira R; Ybanez S; Chene G; Morlat P; Lacoste D; Loury-Lariviere I; Nouts C; Burucoa B; Lebras M; Beylot J
- The treatment of tuberculosis in HIV-infected persons [editorial]
- AIDS. 1999 Mar 11;13(4):435-45. Unique Identifier : AIDSLINE MED/99211228
- Pozniak AL; Miller R; Ormerod LP
- Longitudinal analysis of serum chemokine levels in the course of HIV-1 infection.
- AIDS. 1999 Mar 11;13(4):447-54. Unique Identifier : AIDSLINE MED/99211229
- Polo S; Veglia F; Malnati MS; Gobbi C; Farci P; Raiteri R; Sinicco A; Lusso P; Unit of Human Virology, DIBIT, San Raffaele Scientific Institute,; Milan, Italy.
- OBJECTIVES: To investigate the correlation between the serum levels of the CC-chemokines RANTES, macrophage inflammatory protein (MIP)-1alpha and MIP-1beta, and the progression of HIV-1 disease. DESIGN: Retrospective analysis of serial serum samples from HIV-1 seroconverters selected according to clinical outcome. MET
- Acute upregulation of CCR-5 expression by CD4+ T lymphocytes in HIV-infected patients treated with interleukin-2. ANRS 048 IL-2 Study Group.
- AIDS. 1999 Mar 11;13(4):455-63. Unique Identifier : AIDSLINE MED/99211230
- Zou W; Foussat A; Houhou S; Durand-Gasselin I; Dulioust A; Bouchet L; Galanaud P; Levy Y; Emilie D; INSERM U131, Institut Paris-Sud sur les Cytokines and Service de; Medecine Interne et d'Immunologie Clinique, Hopital Antoine; Beclere, Clamart, France.
- BACKGROUND: The treatment of HIV-infected patients with interleukin (IL)-2 causes a sustained increase in CD4+ T-lymphocyte counts, involving both naive and memory cells. However, the short-term immunological effects of IL-2 , which may shed light on the mechanism of im
- Redistribution of body fat in HIV-infected women undergoing combined antiretroviral therapy.
- AIDS. 1999 Mar 11;13(4):465-71. Unique Identifier : AIDSLINE MED/99211231
- Gervasoni C; Ridolfo AL; Trifiro G; Santambrogio S; Norbiato G; Musicco M; Clerici M; Galli M; Moroni M; Institute of Infectious Diseases and Tropical Medicine, L. Sacco; Hospital, Milan, Italy.
- OBJECTIVES: To investigate the prevalence, metabolic features and risk factors of a particular pattern of fat redistribution (FR), characterized by a progressive enlargement of breast and abdominal girth associated with a wasting of the lower limbs, observed in HIV-infected women treated with combined antiretroviral (
- Urological complaints in relation to indinavir plasma concentrations in HIV-infected patients.
- AIDS. 1999 Mar 11;13(4):473-8. Unique Identifier : AIDSLINE MED/99211232
- Dieleman JP; Gyssens IC; van der Ende ME; de Marie S; Burger DM; Department of Internal Medicine, Erasmus University Medical; School, Rotterdam, The Netherlands.
- OBJECTIVE: To assess the relationship between indinavir-associated urological complaints and indinavir plasma concentrations. DESIGN: Case series, comparing indinavir plasma concentrations in cases with average concentrations in a control group. METHODS: Patients taking 800 mg indinavir three times a day (tid), who pr
- A phase I/II study of the safety and pharmacokinetics of nevirapine in HIV-1-infected pregnant Ugandan women and their neonates (HIVNET 006).
- AIDS. 1999 Mar 11;13(4):479-86. Unique Identifier : AIDSLINE MED/99211233
- Musoke P; Guay LA; Bagenda D; Mirochnick M; Nakabiito C; Fleming T; Elliott T; Horton S; Dransfield K; Pav JW; Murarka A; Allen M; Fowler MG; Mofenson L; Hom D; Mmiro F; Jackson JB; Department of Paediatrics, Makerere University, Kampala, Uganda.
- OBJECTIVE: To determine the safety, pharmacokinetics, tolerance, antiretroviral activity, and infant HIV infection status after giving a single dose of nevirapine to HIV-1-infected pregnant women during labor and their newborns during the first week o
- The effect of Plasmodium falciparum malaria on HIV-1 RNA blood plasma concentration.
- AIDS. 1999 Mar 11;13(4):487-94. Unique Identifier : AIDSLINE MED/99211234
- Hoffman IF; Jere CS; Taylor TE; Munthali P; Dyer JR; Wirima JJ; Rogerson SJ; Kumwenda N; Eron JJ; Fiscus SA; Chakraborty H; Taha TE; Cohen MS; Molyneux ME; University of North Carolina, Division of Infectious Diseases,; Chapel Hill, USA. hoffmani@med.unc.edu
- OBJECTIVES: This study was undertaken to determine the relative effect of malaria infection on HIV concentration in blood plasma, and prospectively to monitor viral concentrations after antimalarial therapy. DESIGN: A prospective, double cohort study was designed to compare the blood HIV-1 RNA concentrations of HIV-po
- Micronutrient supplementation in the AIDS diarrhoea-wasting syndrome in Zambia: a randomized controlled trial.
- AIDS. 1999 Mar 11;13(4):495-500. Unique Identifier : AIDSLINE MED/99211235
- Kelly P; Musonda R; Kafwembe E; Kaetano L; Keane E; Farthing M; Digestive Diseases Research Centre, St Bartholomew's and the; Royal London School of Medicine and Dentistry.
- OBJECTIVE: As HIV has spread through sub-Saharan Africa, persistent diarrhoea has emerged as a major problem in hospitals and in the community in severely affected areas. We have previously demonstrated that antiprotozoal therapy with albendazole reduces diarrhoea in AIDS patients in urban
- Isoniazid prophylaxis for tuberculosis in HIV infection: a meta-analysis of randomized controlled trials.
- AIDS. 1999 Mar 11;13(4):501-7. Unique Identifier : AIDSLINE MED/99211236
- Bucher HC; Griffith LE; Guyatt GH; Sudre P; Naef M; Sendi P; Battegay M; Medizinische Universitats-Poliklinik, Kantonsspital Basel,; Switzerland.
- OBJECTIVES: To evaluate the efficacy of isoniazid for the prevention of tuberculosis in tuberculin skin test-positive and negative individuals with HIV infection. DESIGN: Meta-analysis of randomized controlled trials. SETTING: Seven trials from Mexico ,
- HIV-1 seroprevalence among childbearing women in northern Thailand: monitoring a rapidly evolving epidemic.
- Unique Identifier : AIDSLINE MED/99211237
- Bunnell RE; Yanpaisarn S; Kilmarx PH; Rhodes PH; Limpakarnjanarat K; Srismith R; Mastro TD; St Louis ME
- OBJECTIVES: To describe trends in prevalence of HIV-1 infection among women giving birth at Chiang Rai Hospital (CRH) and to assess risk factors associated with HIV infection in this population. DESIGN: Analysis of hospital registry data for all deliveries at CRH from 1990 to mid-1997. METHODS: From 1990 to
- Impaired fertility in HIV-1-infected pregnant women: a clinic-based survey in Abidjan, Cote d'Ivoire, 1997.
- AIDS. 1999 Mar 11;13(4):517-21. Unique Identifier : AIDSLINE MED/99211238
- Desgrees du Lou A; Msellati P; Yao A; Noba V; Viho I; Ramon R; Welffens-Ekra C; Dabis F; Institut de Recherche pour le Development, Programme Sida,; Abidjan, Cote d'Ivoire.
- OBJECTIVE: Differences in fertility among HIV-1-positive and HIV-negative women tested in prenatal clinics were suspected by routine data collection in Abidjan, Cote d Ivoire . This study was conducted on detailed fertility patterns among women at the same antenatal care centre
- Hepatitis C virus (HCV) genotype does not appear to be a significant prognostic factor in HIV-HCV-coinfected patients [letter]
- AIDS. 1999 Mar 11;13(4):523-4. Unique Identifier : AIDSLINE MED/99211239
- Piroth L; Bourgeois C; Dantin S; Waldner A; Grappin M; Portier H; Chavanet P
- Incidence of rash and discontinuation of nevirapine using two different escalating initial doses [letter]
- AIDS. 1999 Mar 11;13(4):524-5. Unique Identifier : AIDSLINE MED/99211240
- Anton P; Soriano V; Jimenez-Nacher I; Rodriguez-Rosado R; Dona MC; Barreiro PM; Gonzalez-Lahoz J
- Patterns of response (CD4 cell count and viral load) at 6 months in HIV-infected patients on highly active antiretroviral therapy [letter]
- AIDS. 1999 Mar 11;13(4):525-6. Unique Identifier : AIDSLINE MED/99211241
- Barreiro PM; Dona MC; Castilla J; Soriano V
- Estimation of HIV-1 prevalence in the population of Abidjan by adjustment of the prevalence observed in antenatal centres [letter]
- AIDS. 1999 Mar 11;13(4):526-7. Unique Identifier : AIDSLINE MED/99211242
- Desgrees du Lou A; Msellati P; La Ruche G; Welffens-Ekra C; Ramon R; Dabis F
- Interleukin-2 treatment of microglia has no effect on in vitro HIV infection [letter]
- AIDS. 1999 Mar 11;13(4):527-8. Unique Identifier : AIDSLINE MED/99211243
- Albright AV; Frank I; Gonzalez-Scarano F
- HIV-1 infection in a heterosexual man homozygous for CCR-5 delta32 [letter]
- AIDS. 1999 Mar 11;13(4):529-30. Unique Identifier : AIDSLINE MED/99211244
- Heiken H; Becker S; Bastisch I; Schmidt RE
- Visual loss due to cryptococcal meningitis in AIDS patients [letter]
- AIDS. 1999 Mar 11;13(4):530-2. Unique Identifier : AIDSLINE MED/99211245
- Torres OH; Negredo E; Ris J; Domingo P; Catafau AM
- V3-loop and nef gene sequences of HIV-1 isolates from a hemophiliac cohort with long-term non-progressive infection [letter]
- AIDS. 1999 Mar 11;13(4):532-4. Unique Identifier : AIDSLINE +
- Vallejo A; Mas A; Heredia A; Altisent C; Lorenzo I; Soriano V; Hewlett IK
- Pneumocystosis versus pulmonary Pneumocystis carinii colonization in HIV-negative and HIV-positive patients [letter]
- AIDS. 1999 Mar 11;13(4):535-6. Unique Identifier : AIDSLINE MED/99211247
- Nevez G; Raccurt C; Jounieaux V; Dei-Cas E; Mazars E
- Genital herpes simplex virus type 2 shedding is increased in HIV-infected women in Africa [letter]
- AIDS. 1999 Mar 11;13(4):536-7. Unique Identifier : AIDSLINE MED/99211248
- Mbopi Keou FX; Gresenguet G; Mayaud P; Weiss HA; Gopal R; Brown DW; Hayes RJ; Mabey DC; Belec L
- Thymus volume correlates with the progression of vertical HIV infection.
- AIDS. 1999 Apr 1;13(5):F29-34. Unique Identifier : AIDSLINE MED/99218040
- Vigano' A; Vella S; Principi N; Bricalli D; Sala N; Salvaggio A; Saresella M; Vanzulli A; Clerici M; Cattedra di Pediatria IV, Universita di Milano, Ospedale Luigi; Sacco, Milan, Italy.
- BACKGROUND: The thymus is the organ responsible for the maturation and selection of T lymphocytes and is thus pivotal in allowing the development of a functional immune system. Because in HIV infection cell-mediated immune responses are severely impaired, we studied the role of thymus in the control of the progression
- Management of chronic hepatitis C in HIV-infected patients [editorial]
- AIDS. 1999 Apr 1;13(5):539-46. Unique Identifier : AIDSLINE MED/99218041
- Soriano V; Rodriguez-Rosado R; Garcia-Samaniego J
- Chemokine and chemokine receptor expression after combined anti-HIV-1 interleukin-2 therapy.
- AIDS. 1999 Apr 1;13(5):547-55. Unique Identifier : AIDSLINE MED/99218042
- Blanco J; Cabrera C; Jou A; Ruiz L; Clotet B; Este JA; Institut de Recerca de la SIDA-Caixa, Laboratori de; Retrovirologia, Hospital Universitari Germans Trias i Pujol,; Barcelona, Catalonia, Spain.
- OBJECTIVE: To evaluate changes in serum levels of chemokines, chemokine production, and chemokine receptor expression by peripheral blood mononuclear cells (PBMC), after treatment of HIV-1-infected individuals with interleukin (IL)-2. METHODS: We determined CC-chemokine levels by enzyme-linked immunosorbent assay and
- Natural immunity and HIV disease progression.
- AIDS. 1999 Apr 1;13(5):557-63. Unique Identifier : AIDSLINE MED/99218043
- Ullum H; Cozzi Lepri A; Aladdin H; Katzenstein T; Victor J; Phillips AN; Gerstoft J; Skinhoj P; Klarlund Pedersen B; Department of Infectious Diseases, Rhima Centre, Rigshospitalet,; Copenhagen, Denmark.
- OBJECTIVE: To investigate the clinical implications of impaired levels of the natural immunity mediated by natural killer (NK) cells and lymphokine activated killer (LAK) cells during infection with HIV-1. DESIGN: Data used were from 172 individuals with an estimated measure of NK cell activity and 146 with an estimat
- An evaluation of HIV RNA and CD4 cell count as surrogates for clinical outcome. Delta Coordinating Committee and Virology Group.
- AIDS. 1999 Apr 1;13(5):565-73. Unique Identifier : AIDSLINE MED/99218044
- OBJECTIVES: To evaluate the role of viral load, as measured by HIV-1 RNA, and CD4 cell counts as surrogates for clinical outcome using the data from the Delta trial. METHODS: A total of 1280 participants (40% of the 3207 participants in the Delta trial) with baseline and at least one other serum sample stored at -70 d
- Predictors of survival and eradication of Mycobacterium avium complex bacteremia (MAC) in AIDS patients in the Canadian randomized MAC treatment trial. Canadian HIV Trials Network Protocol 010 Study Group.
- AIDS. 1999 Apr 1;13(5):575-82. Unique Identifier : AIDSLINE MED/99218045
- Singer J; Thorne A; Phillips P; Rachlis AR; Miller M; Gill MJ; Smaill FM; Schlech WF 3rd; Senay H; Shafran SD; Canadian HIV Trials Network and the Department of Health Care and; Epidemiology, University of British Columbia, Vancouver, Canada.
- OBJECTIVE: To assess the importance of baseline characteristics including medical history, indicators of current disease status, therapeutic drug use, in vitro drug susceptibility, immune status and mycobacterial load on bacteriologic response and survival in HIV-positive patients with Mycobacterium avium complex (MAC
- Stable antenatal HIV-1 seroprevalence with high population mobility and marked seroprevalence variation among sentinel sites within Nairobi, Kenya.
- AIDS. 1999 Apr 1;13(5):583-9. Unique Identifier : AIDSLINE MED/99218046
- Jackson DJ; Ngugi EN; Plummer FA; Kirui P; Kariuki C; Ndinya-Achola JO; Bwayo JJ; Moses S; Department of Community Health, University of Nairobi, Kenya.
- OBJECTIVES: To monitor and analyse trends in HIV-1 seroprevalence among antenatal women in Nairobi, Kenya . DESIGN: Six sequential surveys were carried out among antenatal clinic attenders at four Nairobi City Council health centres between November 1991 and April 1997. METHODS: A to
- Sexual, contraceptive, and drug use behaviors of women with HIV and those at high risk for infection: results from the Women's Interagency HIV Study.
- AIDS. 1999 Apr 1;13(5):591-8. Unique Identifier : AIDSLINE MED/99218047
- Wilson TE; Massad LS; Riester KA; Barkan S; Richardson J; Young M; Gurtman A; Greenblatt R; State University of New York, Downstate Medical Center, Brooklyn; 11203, USA.
- OBJECTIVE: To document the sexual and contraceptive practices of women with HIV infection or who are at risk for infection. DESIGN: Data on the baseline behaviors of 561 HIV-negative and 2040 HIV-positive women were collected as part of the Women s Interagency HIV Study (WIHS). WIHS is a multisite, longitudinal study
- Nosocomial infections in HIV infected patients. Gruppo HIV e Infezioni Ospedaliere.
- AIDS. 1999 Apr 1;13(5):599-605. Unique Identifier : AIDSLINE MED/99218048
- Petrosillo N; Pugliese G; Girardi E; Pallavicini F; Carosi G; Moro ML; Ippolito G; Centro di Riferimento AIDS e Servizio di Epidemiologia delle; Malattie Infettive, IRCCS L. Spallanzani, Rome, Italy.
- OBJECTIVES: To determine the incidence of nosocomial infections (NI) in HIV-infected patients and to analyse some of the associated risk factors. DESIGN AND SETTING: Multicentre prospective study on consecutive HIV-infected patients admitted to 19 Italian acute-care infectious disease wards. METHODS: All patients admi
- Cofactors for the acquisition of HIV-1 among heterosexual men: prospective cohort study of trucking company workers in Kenya.
- AIDS. 1999 Apr 1;13(5):607-14. Unique Identifier : AIDSLINE MED/99218049
- Rakwar J; Lavreys L; Thompson ML; Jackson D; Bwayo J; Hassanali S; Mandaliya K; Ndinya-Achola J; Kreiss J; Department of Medical Microbiology, University of Nairobi, Kenya.
- OBJECTIVE: To determine the prevalence, incidence, and correlates of HIV-1 infection in a cohort of east African trucking company employees. METHODS: HIV-1-seronegative trucking company employees were enrolled in a prospective cohort study and evaluated at 3 monthly intervals for HIV-1 seroconversion, sexually transmi
- Evidence of exogenous reinfection and mixed infection with more than one strain of Mycobacterium tuberculosis among Spanish HIV-infected inmates.
- Unique Identifier : AIDSLINE MED/99218050
- Chaves F; Dronda F; Alonso-Sanz M; Noriega AR
- BACKGROUND: As prisons have a high prevalence of tuberculosis and HIV infection, we studied the possibility of multiple tuberculosis infections in a selected population of HIV-infected inmates. METHODS: Two groups of patients with special characteristics were selected from 226 HIV-infected inmates diagnosed with tuber
- CD4+CD7-lymphocyte subset is expanded in HIV-infected patients with low CD4 cell count rescue during highly active antiretroviral therapy [letter]
- AIDS. 1999 Apr 1;13(5):621-2. Unique Identifier : AIDSLINE MED/99218051
- Meroni L; Varchetta S; Manganaro D; Moscatelli G; Moroni M; Galli M
- Acute porphyria following commencement of indinavir [letter]
- AIDS. 1999 Apr 1;13(5):622-3. Unique Identifier : AIDSLINE MED/99218052
- Fox PA; Boag FC; Hawkins DA; Francis N
- Early diagnosis of acquired ocular syphilis requires a high index of suspicion and may prevent visual loss [letter]
- AIDS. 1999 Apr 1;13(5):623-4. Unique Identifier : AIDSLINE MED/99218053
- Schurmann D; Bergmann F; Bertelmann E; Padberg J; Liekfeld A; Pleyer U
- CC-chemokine receptor variants, SDF-1 polymorphism, and disease progression in 720 HIV-infected patients. SEROCO Cohort. Amsterdam Cohort Studies on AIDS [letter]
- AIDS. 1999 Apr 1;13(5):624-6. Unique Identifier : AIDSLINE MED/99218054
- Meyer L; Magierowska M; Hubert JB; Theodorou I; van Rij R; Prins M; de Roda Husman AM; Coutinho R; Schuitemaker H
- Frequent cervicovaginal shedding of HIV-1 in asymptomatic, non-severely immunodeficient women [letter]
- AIDS. 1999 Apr 1;13(5):626-7. Unique Identifier : AIDSLINE MED/99218055
- Fiore JR; Lepera A; Di Stefano M; Saracino A; Favia A; Pastore G; Angarano G
- High prevalence of multiple drug resistance mutations in a UK HIV/AIDS patient population [letter]
- AIDS. 1999 Apr 1;13(5):627-8. Unique Identifier : AIDSLINE MED/99218056
- Loveday C; Devereux H; Huckett L; Johnson M
- Clinical improvement of HIV-associated psoriasis parallels a reduction of HIV viral load induced by effective antiretroviral therapy [letter]
- AIDS. 1999 Apr 1;13(5):628-9. Unique Identifier : AIDSLINE MED/99218057
- Fischer T; Schworer H; Vente C; Reich K; Ramadori G
- Use of dried whole blood spots for quantification of HIV-1 RNA [letter]
- AIDS. 1999 Apr 1;13(5):630-1. Unique Identifier : AIDSLINE MED/99218058
- O'Shea S; Mullen J; Corbett K; Chrystie I; Newell ML; Banatvala JE
- Communication about sexual issues: mothers, fathers, and friends.
- J Adolesc Health. 1999 Mar;24(3):181-9. Unique Identifier : AIDSLINE MED/99210176
- DiIorio C; Kelley M; Hockenberry-Eaton M; Behavioral Science and Health Education, Rollins School of Public; Health, and Nell Hodgson Woodruff School of Nursing, Emory; University, Atlanta, Georgia 30322, USA.
- PURPOSE: To identify the content, characteristics, and comfort level of discussions about sexuality held between mothers and their early adolescent children and to determine the extent to which the conversations predicted sexual values and initiation of sexual intercourse of the adolescent. METHODS: This was part of a
- Membrane interactions of the synthetic N-terminal peptide of HIV-1 gp41 and its structural analogs.
- Unique Identifier : AIDSLINE MED/99227091
- Mobley PW; Waring AJ; Sherman MA; Gordon LM
- Structural and functional studies assessed the membrane actions of the N terminus of HIV-1 glycoprotein 41000 (gp41). Earlier
- Conformation, pH-induced conformational changes, and thermal unfolding of anti-p24 (HIV-1) monoclonal antibody CB4-1 and its Fab and Fc fragments.
- Biochim Biophys Acta. 1999 Apr 12;1431(1):120-31. Unique Identifier : AIDSLINE MED/99227077
- Welfle K; Misselwitz R; Hausdorf G; Hohne W; Welfle H; Max-Delbruck-Centrum fur Molekulare Medizin,; Robert-Rossle-Str. 10, D-13092, Berlin, Germany.; welfle@mdc-berlin.de
- Conformation, acid-induced conformational changes and stability of the murine monoclonal antibody CB4-1 directed against the human immunodeficiency virus type 1 capsid protein p24, and its Fab and Fc fragments, were analysed by circular dichroism (CD), fluorescence, and differential scanning calorimetry (DSC) measurem
- Photo quiz. Aberrant fat deposition (benign lipomatosis) in association with highly active antiretroviral therapy.
- Clin Infect Dis. 1999 Feb;28(2):239, 351. Unique Identifier : AIDSLINE MED/99162000
- Azmeh W; Rhagavan SS; El-Sadr W; Division of Infectious Diseases, Harlem Hospital Center, Columbia; University College of Physicians and Surgeons, New York, New York; 10037, USA. wme1@columbia.edu
- A comparison of itraconazole versus fluconazole as maintenance therapy for AIDS-associated cryptococcal meningitis. National Institute of Allergy and Infectious Diseases Mycoses Study Group [see comments]
- Clin Infect Dis. 1999 Feb;28(2):291-6. Unique Identifier : AIDSLINE MED/99162009
- Saag MS; Cloud GA; Graybill JR; Sobel JD; Tuazon CU; Johnson PC; Fessel WJ; Moskovitz BL; Wiesinger B; Cosmatos D; Riser L; Thomas C; Hafner R; Dismukes WE; Department of Medicine, Comprehensive Cancer Center, University; of Alabama School of Medicine at Birmingham 35294-2050, USA.; msaag@uab.edu
- This study was designed to compare the effectiveness of fluconazole vs. itraconazole as maintenance therapy for AIDS-associated cryptococcal meningitis. HIV-infected patients who had been successfully treated (achieved negative culture of CSF) for a first episode of cryptococcal meningitis were randomized to receive f
- Editorial response: A comparison of itraconazole versus fluconazole as maintenance therapy for AIDS-associated cryptococcal meningitis [editorial; comment]
- Clin Infect Dis. 1999 Feb;28(2):297-8. Unique Identifier : AIDSLINE MED/99162010
- Larsen RA
- Cryptococcosis in children with AIDS.
- Clin Infect Dis. 1999 Feb;28(2):309-13. Unique Identifier : AIDSLINE MED/99162012
- Abadi J; Nachman S; Kressel AB; Pirofski L; Department of Microbiology and Immunology, Albert Einstein; College of Medicine, Bronx, New York 10461, USA.
- We compiled the clinical and immunologic features of Cryptococcus neoformans infections in human immunodeficiency virus (HIV)-infected children from 1985 to 1996 in a retrospective case series. Thirty cases of cryptococcosis were identified. These children had a median age of 9.8 years, a median CD4+ cell count of 54/
- Cryptosporidium, enterocytozoon, and cyclospora infections in pediatric and adult patients with diarrhea in Tanzania.
- Clin Infect Dis. 1999 Feb;28(2):314-21. Unique Identifier : AIDSLINE MED/99162013
- Cegielski JP; Ortega YR; McKee S; Madden JF; Gaido L; Schwartz DA; Manji K; Jorgensen AF; Miller SE; Pulipaka UP; Msengi AE; Mwakyusa DH; Sterling CR; Reller LB; Duke University Medical Center, Durham, North Carolina, USA.; gzc2@cdc.gov
- Cryptosporidiosis, microsporidiosis , and cyclosporiasis were studied in four groups of Tanzanian inpatients: adults with AIDS-associated diarrhea, children with chronic diarrhea (of whom 23 of 59 were positive [+] for human immunodeficiency virus [HIV]), children with
- Human immunodeficiency virus-associated fever of unknown origin: a study of 70 patients in the United States and review.
- Clin Infect Dis. 1999 Feb;28(2):341-5. Unique Identifier : AIDSLINE MED/99162016
- Armstrong WS; Katz JT; Kazanjian PH; Department of Internal Medicine, University of Michigan Medical; Center, Ann Arbor 48109-0378, USA.
- To characterize the clinical features of human immunodeficiency virus (HIV)-associated fever of unknown origin (FUO) in the United States , we performed a retrospective analysis of cases that fulfilled specific criteria (published by Durack and Street in 1991) at two medical centers in
- Fluoroquinolone toxicity profiles: a review focusing on newer agents.
- Clin Infect Dis. 1999 Feb;28(2):352-64. Unique Identifier : AIDSLINE MED/99162018
- Lipsky BA; Baker CA; Veterans Affairs Puget Sound Health Care System and University of; Washington School of Medicine, Seattle 98108-1532, USA.
- For 2 decades fluoroquinolones have been found to be generally well-tolerated and safe. Adverse events may be inherent to the class or influenced by structural modifications. The commonest adverse events are gastrointestinal tract (GI) and central nervous system (CNS) reactions; nephrotoxicity and tendinitis are infre
- Occupational human immunodeficiency virus infection in health care workers: worldwide cases through September 1997.
- Clin Infect Dis. 1999 Feb;28(2):365-83. Unique Identifier : AIDSLINE MED/99162019
- Ippolito G; Puro V; Heptonstall J; Jagger J; De Carli G; Petrosillo N; Centro di Riferimento AIDS e Servizio di Epidemiologia delle; Malattie Infettive IRCCS Lazzaro Spallanzani, Rome, Italy.; craids@excalhq.it
- The average estimated risk of human immunodeficiency virus (HIV) infection for health care workers following a percutaneous or mucous exposure is
- Plasma and cerebrospinal fluid saquinavir concentrations in patients receiving combination antiretroviral therapy.
- Clin Infect Dis. 1999 Feb;28(2):403-4. Unique Identifier : AIDSLINE MED/99162025
- Moyle GJ; Sadler M; Buss N; HIV/Genito-Urinary Medicine Department, Chelsea and Westminster; Hospital, London, United Kingdom. gm@moyleg.demon.co.UK
- Refractory mucosal candidiasis in patients with human immunodeficiency virus infection [letter]
- Clin Infect Dis. 1999 Feb;28(2):407-8. Unique Identifier : AIDSLINE MED/99162028
- Phillips P
- Community-acquired pneumonia in human immunodeficiency virus-infected patients [letter]
- Clin Infect Dis. 1999 Feb;28(2):410-1. Unique Identifier : AIDSLINE MED/99162031
- Cunha BA
- [AIDS and primary care: homework still remains. Let's not allow any opportunity to escape (letter)]
- Aten Primaria. 1999 Mar 31;23(5):312. Unique Identifier : AIDSLINE MED/99273012
- Gonzalez E; Rodriguez A
- Cisplatin at clinically relevant concentrations enhances interleukin-2 synthesis by human primary blood lymphocytes.
- Anticancer Drugs. 1999 Feb;10(2):219-27. Unique Identifier : AIDSLINE MED/99226535
- Riesbeck K; Department of Medical Microbiology, Malmo University Hospital,; Lund University, Sweden. kristian.riesbeck@mikrobiol.mas.lu.se
- Cytotoxic drugs influence the expression of certain genes in cancer cells. Cisplatin has recently been shown to modulate interleukin (IL)-1 and tumor necrosis factor (TNF)-alpha production in macrophages. In this study, we wanted to investigate whether cisplatin interferes with the
- Iritis associated with intravenous cidofovir.
- Ann Pharmacother. 1999 Feb;33(2):167-71. Unique Identifier : AIDSLINE MED/99181902
- Tseng AL; Mortimer CB; Salit IE; The Toronto Hospital, Faculty of Pharmacy, University of Toronto,; Ontario, Canada. atseng@torhosp.toronto.on.ca
- OBJECTIVE: To report two patients with AIDS and cytomegalovirus retinitis who developed iritis after receiving intravenous cidofovir. Both experienced recurrent symptoms upon rechallenge. CASE SUMMARIES: Two HIV-positive patients with cytomegalovirus retinitis infections previously
- The use of combination antiretroviral therapy in HIV-infected patients.
- Ann Pharmacother. 1999 Feb;33(2):198-209. Unique Identifier : AIDSLINE MED/99181907
- Holtzer CD; Roland M; School of Pharmacy, University of California, San Francisco; General Hospital, 94110, USA. choltzer@sfaids.ucsf.edu
- OBJECTIVE: To review the published clinical trials of combination antiretroviral therapy, current guidelines about the use of combination antiretroviral therapy, information regarding the impact of adherence on treatment effect, and the effects of combination antiretroviral therapy on morbidity and mortality. METHODS:
- Nonprescription and alternative medication use by individuals with HIV disease.
- Ann Pharmacother. 1999 Mar;33(3):294-300. Unique Identifier : AIDSLINE MED/99216859
- Smith SR; Boyd EL; Kirking DM; Division of Pharmaceutical Policy and Evaluative Sciences, School; of Pharmacy, University of North Carolina at Chapel Hill 27599,; USA.
- OBJECTIVE: To examine the strength of the associations between predisposing, enabling, and need-for-care variables and the self-treatment of HIV disease; and to compare sociodemographic and illness-related factors associated with the use of vitamins, nonprescription medications, herbs, and recreational substances amon
- Nelfinavir mesylate: a protease inhibitor.
- Unique Identifier : AIDSLINE MED/99216866
- Pai VB; Nahata MC
- OBJECTIVE: To review the clinical pharmacology, pharmacokinetics, efficacy, adverse effects, drug interactions, and dosage guidelines of nelfinavir mesylate. DATA SOURCE: A MEDLINE search restricted to English-language literature from January 1966 to February 1998 and an extensive review of journals was conducted to p
- Fatal Stevens-Johnson syndrome in an AIDS patient treated with sulfadiazine [letter]
- Ann Pharmacother. 1999 Mar;33(3):379-80. Unique Identifier : AIDSLINE MED/99216873
- Carrion-Carrion C; Morales-Suarez-Varela MM; Llopis-Gonzalez A
- Italian guidelines for antiretroviral therapy in children with human immunodeficiency virus-type 1 infection. Italian Register for HIV Infection in Children.
- Acta Paediatr. 1999 Feb;88(2):228-32. Unique Identifier : AIDSLINE MED/99200284
- Human immunodeficiency virus-type 1 (HIV-1) infection and its treatment are peculiar in children. Adherence and compliance must be carefully taken into account before initiating or changing therapy and in the choice of drugs. Even in the absence of paediatric-specific trial results and notwithstanding drug-labelling n
- Lymphomatoid granulomatosis following autologous stem cell transplantation.
- Bone Marrow Transplant. 1999 Jan;23(1):79-81. Unique Identifier : AIDSLINE MED/99154658
- Fassas A; Jagannath S; Desikan KR; Shah HR; Shaver R; Waldron J; Munshi NC; Barlogie B; Tricot G; University of Arkansas for Medical Sciences and Arkansas Cancer; Research Center, Little Rock, USA.
- Lymphomatoid granulomatosis (LYG) is a rare angio-destructive lymphoproliferative disorder (LPD) of uncertain etiology, with prominent pulmonary involvement. Recent studies indicate that LYG is an Epstein-Barr virus (EBV)-associated B cell LPD with large numbers of background reactive T lymphocytes (T cell-rich B cell
- Encephalitozoon intestinale infection in an AIDS patient--a case report.
- Cent Eur J Public Health. 1999 Feb;7(1):43-6. Unique Identifier : AIDSLINE MED/99183768
- Kucerova-Pospisilova Z; Stankova M; Ditrich O; Institute of Parasitology, Academy of Sciences of the Czech; Republic, Ceske Budejovice, Czech Republic.
- The first case of one of the most frequent intestinal microsporidians, Encephalitozoon intestinale, is reported from an AIDS patient in the Czech Republic . The patient experienced diarrhoea and was found to have microsporidia spores in stool. Species determination by electro
- Evaluating interviewing techniques for the sexual practices history. Use of video trigger tapes to assess patient comfort.
- Arch Fam Med. 1999 May-Jun;8(3):218-23. Unique Identifier : AIDSLINE MED/99266358
- Floyd M; Lang F; Beine KL; McCord E; Department of Family Medicine, James H. Quillen College of; Medicine, East Tennessee State University, Johnson City, USA.; floyd@etsu.edu
- BACKGROUND: Although physicians recognize the importance of assessing a patient s risk for human immunodeficiency virus (HIV) infection, many are reluctant to explore a person s sexual history, a principal determinant of this risk. OBJECTIVE: To examine the feasibility of a research design that uses responses to viewi
- Lymphoepithelial duct lesions in Sjogren-type sialadenitis.
- Virchows Arch. 1999 Apr;434(4):315-23. Unique Identifier : AIDSLINE MED/99266973
- Ihrler S; Zietz C; Sendelhofert A; Riederer A; Lohrs U; Institute of Pathology, Ludwig Maximilians University of Munich,; Germany.
- It is not clear, whether the so-called basal cells of the salivary striated ducts are an independent cell-type distinct from myoepithelial cells, making characterization of the cell proliferation typical of the duct lesions in Sjogren-type sialadenitis/benign lymphoepithelial lesion (BLEL) difficult. An immunohistoche
- Molecular modeling, synthesis, and structures of N-methylated 3,5-linked pyrrolin-4-ones toward the creation of a privileged nonpeptide scaffold.
- Bioorg Med Chem. 1999 Jan;7(1):9-22. Unique Identifier : AIDSLINE MED/99213744
- Smith AB 3rd; Favor DA; Sprengeler PA; Guzman MC; Carroll PJ; Furst GT; Hirschmann R; Department of Chemistry, University of Pennsylvania, Philadelphia; 19104, USA.
- The molecular modeling, synthesis, and elucidations of the solid state and solution structures of N-methylated 3,5-linked bispyrrolin-4-ones are described. Prior investigations established that the 3,5-linked pyrrolin-4-one based scaffold can be incorporated into mimics of beta-sheet/beta-strands and into potent, oral
- The origins of AIDS.
- Curr Biol. 1999 Mar 25;9(6):R192. Unique Identifier : AIDSLINE MED/99227335
- Dixon B
- Effects of feline immunodeficiency virus on cognition and behavioral function in cats.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 15;20(5):411-9. Unique Identifier : AIDSLINE MED/99239727
- Steigerwald ES; Sarter M; March P; Podell M; Department of Veterinary Clinical Sciences, Comprehensive Cancer; Center, The Ohio State University, Columbus, USA.
- Experimental intravenous challenge of 8-week old cats with the Maryland isolate of feline immunodeficiency virus, Maryland isolate (FIV-MD) was investigated for its effects on cognitive and behavioral function at 12 months postinfection. Six cats infected with FIV-MD were compared with age-matched controls on several
- Increased intracellular accumulation of macrophage inflammatory protein 1beta and its decreased secretion correlate with advanced HIV disease.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 15;20(5):420-2. Unique Identifier : AIDSLINE MED/99239728
- Tartakovsky B; Turner D; Vardinon N; Burke M; Yust I; Clinical Immunology and AIDS Center, Department of Medicine A,; Tel-Aviv Sourasky Medical Center, Israel. tartabor@hotmail.com
- Considering that the chemokine macrophage inflammatory protein 1beta (MIP1beta) may serve as a competitive inhibitor for HIV entry, the objective of this study was to compare intracellular and extracellular levels of MIP1beta, in untreated HIV-infected individuals. HIV patients and healthy controls were tested by two-
- Growth hormone in immune reconstitution.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 15;20(5):423-31. Unique Identifier : AIDSLINE MED/99239729
- Chappel S; Serono Laboratories Inc., Norwell, Massachusetts 02061, USA.
- Immune cell death or dysfunction is induced by HIV infection and results in an immunocompromised state. Newer treatments are able to control viral replication to prevent massive cytoreduction. Attention must now focus on therapies that will rapidly reconstitute the immune system to provide defense against future HIV a
- V3 serotyping of HIV-1 infection: correlation with genotyping and limitations.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 15;20(5):432-41. Unique Identifier : AIDSLINE MED/99239730
- Plantier JC; Damond F; Lasky M; Sankale JL; Apetrei C; Peeters M; Buzelay L; M'Boup S; Kanki P; Delaporte E; Simon F; Barin F; Laboratoire de Virologie, Universite Francois Rabelais, Tours,; France.
- HIV-1 V3 serotyping is a classification of immunodeficiency viruses based on antibody binding to V3 peptides that allows obtaining information on circulating subtypes that could be important for population-based epidemiologic studies. Recently, several laboratories have developed V3 enzyme-immunoassays (EIAs) using V3
- Detection and enumeration of HIV-1-producing cells by ELISPOT (enzyme-linked immunospot) assay.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 15;20(5):442-7. Unique Identifier : AIDSLINE MED/99239731
- Corne P; Huguet MF; Briant L; Segondy M; Reynes J; Vendrell JP; Laboratoire d'Immunologie des Infections Retrovirales, Centre; National de la Recherche Scientifique, Institut de Biologie,; Montpellier, France.
- The enzyme-linked immunospot (ELISPOT) assay was adapted to detect and enumerate HIV-1-producing cells at the single cell level. With CEM cells or peripheral blood mononuclear cells (PBMC) infected in vitro with HIV-1, the ELISPOT assay detected cells that produced HIV-1 antigens and showed that between 5.4% and 9.5%
- Comparison of clinical manifestations of HIV infection among women by risk group, CD4+ cell count, and HIV-1 plasma viral load. HER Study Group. HIV Epidemiology Research.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 15;20(5):448-54. Unique Identifier : AIDSLINE MED/99239732
- Rompalo AM; Astemborski J; Schoenbaum E; Schuman P; Carpenter C; Holmberg SD; Warren DL; Farzadegan H; Vlahov D; Smith DK; Department of Medicine, The Johns Hopkins School of Medicine,; Baltimore, Maryland 21287-0003, USA.
- OBJECTIVES: To compare the prevalence of HIV-related symptoms, physical examination findings, and hematologic variables among women whose risk for HIV is injection drug use since 1985 as opposed to sexual contact and to evaluate the influence of HIV plasma viral load and CD4+ cell count on clinical manifestations acco
- Comparison of gynecologic history and laboratory results in HIV-positive women with CD4+ lymphocyte counts between 200 and 500 cells/microl and below 100 cells/microl.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 15;20(5):455-62. Unique Identifier : AIDSLINE MED/99239733
- Watts DH; Spino C; Zaborski L; Katzenstein D; Hammer S; Benson C; University of Washington, Department of Obstetrics and; Gynecology, Seattle 98195-6460, USA.
- OBJECTIVE: To assess rates of sexual activity, contraceptive use, genital infections and dysplasia, and other gynecologic symptoms among well-characterized populations of HIV-seropositive women enrolled in two Adult AIDS Clinical Trials Group (AACTG) randomized studies. METHODS: Gynecologic data were collected using s
- Lack of tumors in infants with perinatal HIV-1 exposure and fetal/neonatal exposure to zidovudine.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 15;20(5):463-7. Unique Identifier : AIDSLINE MED/99239734
- Hanson IC; Antonelli TA; Sperling RS; Oleske JM; Cooper E; Culnane M; Fowler MG; Kalish LA; Lee SS; McSherry G; Mofenson L; Shapiro DE; Baylor College of Medicine, Houston, Texas, USA.
- Zidovudine (ZDV) therapy during pregnancy and to the neonate reduced perinatal HIV transmission by nearly 70% in Pediatric AIDS Clinical Trials Group (PACTG) protocol 076. ZDV has been reported as positive in several in vitro carcinogenicity screening tests. We evaluated the short-term risk for tumors in 727 children
- HIV-1 dynamics in children.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 15;20(5):468-73. Unique Identifier : AIDSLINE MED/99239735
- Melvin AJ; Rodrigo AG; Mohan KM; Lewis PA; Manns-Arcuino L; Coombs RW; Mullins JI; Frenkel LM; Department of Pediatrics, University of Washington, Seattle, USA.; ajmelvin@u.washington.edu
- HIV-1-infected children have higher plasma viral loads and progress to disease more quickly than infected adults. To gain insight into the accelerated pathogenesis of HIV-1 in children, viral dynamics were measured following the initiation of highly active antiretroviral therapy (HAART) and compared with those reporte
- Protease inhibitor use among a community sample of people with HIV disease.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 15;20(5):474-80. Unique Identifier : AIDSLINE MED/99239736
- Bing EG; Kilbourne AM; Brooks RA; Lazarus EF; Senak M; Department of Psychiatry, Charles R. Drew University of Medicine; and Science, Los Angeles, California 90059, USA.
- OBJECTIVES: Protease inhibitors have become integral to HIV disease management. This paper examines sociodemographic factors affecting patient use and perceived knowledge of protease inhibitors , and the relationship between protease inhibitor use and perceived healt
- Predominance of CCR5-dependent HIV-1 subtype E isolates in Cambodia.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 15;20(5):481-7. Unique Identifier : AIDSLINE GENBANK/AF062033
- Menu E; Reynes JM; Muller-Trutwin MC; Guillemot L; Versmisse P; Chiron M; An S; Trouplin V; Charneau P; Fleury H; Barre-Sinoussi F; Sainte Marie FF; Institut Pasteur, Unite de Biologie des Retrovirus, Paris,; France.
- To investigate the genetic and biologic features of HIV-1 strains circulating in Cambodia , viruses from 95 HIV-1-seropositive individuals were subtyped by heteroduplex mobility assay (HMA) and 23 were further analyzed for their biologic characteristics. Eighty-nine individuals we
- Feasibility of a preventive HIV-1 vaccine cohort among persons attending sexually transmitted disease clinics in Thailand.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 15;20(5):488-94. Unique Identifier : AIDSLINE MED/99239738
- Markowitz LE; Sirisopana N; Charonwatanachokchai A; Julvanichpong W; Siraprapasiri T; Palanuvej T; Siriwongrangsun P; Tungsakul V; Pumratana K; Chitwarakorn A; Michael RA; Brown AE; Armed Forces Research Institute of Medical Sciences, Bangkok,; Thailand. lem2@cdc.gov
- Persons attending sexually transmitted disease clinics at three sites in Thailand were recruited to participate in a 1-year study of HIV-1 incidence. Between September 1995 and February 1996, 31% (371 of 1205) of eligible men and 24% (161 of 659) of eligible women agreed to parti
- Predictors and risk-taking consequences of drug use among HIV-infected women.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 15;20(5):502-7. Unique Identifier : AIDSLINE MED/99239740
- Novotna L; Wilson TE; Minkoff HL; McNutt LA; DeHovitz JA; Ehrlich I; Des Jarlais DC; State University of New York, School of Public Health at Albany,; USA.
- ObJECTIVE: To determine rates of drug use among women with HIV, and to examine associations between drug use, health, risk behavior, and sexually transmitted diseases (STD). DESIGN: A longitudinal cohort study of 260 women with confirmed HIV-positive serostatus. METHODS: Each participant contributed a self-report inte
- Mortality risk in selenium-deficient HIV-positive children.
- Unique Identifier : AIDSLINE MED/99239741
- Campa A; Shor-Posner G; Indacochea F; Zhang G; Lai H; Asthana D; Scott GB; Baum MK; Center for Disease Prevention, Department of Psychiatry and; Behavioral Sciences, University of Miami School of Medicine,; Florida 33136, USA.
- OBJECTIVE: To determine the independent contribution of specific nutritional factors on disease progression and survival in HIV-1-infected children. POPULATION: HIV-infected children (N = 24), who were perinatally exposed to the virus and symptomatic, were recruited between October and December of 1990 from the Jackso
- Negative result of cytomegalovirus blood culture with restoration of CD4+ T-cell reactivity to cytomegalovirus after HAART in an HIV-1-infected patient [letter]
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 15;20(5):514-5. Unique Identifier : AIDSLINE MED/99239742
- Li TS; Tubiana R; Fillet AM; Autran B; Katlama C
- Has the spectrum of AIDS-defining illnesses been changing since the introduction of new treatments and combination of treatments? [letter]
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 15;20(5):515-6. Unique Identifier : AIDSLINE MED/99239743
- Pezzotti P; Dal Maso L; Serraino D; Franceschi S; Rezza G
- Continuous delivery of human and mouse erythropoietin in mice by genetically engineered polymer encapsulated myoblasts.
- Gene Ther. 1998 Aug;5(8):1014-22. Unique Identifier : AIDSLINE MED/99257873
- Regulier E; Schneider BL; Deglon N; Beuzard Y; Aebischer P; Division of Surgical Research, Centre Hospitalier Universitaire; Vaudois, Lausanne University Medical School, Switzerland.
- The transplantation of polymer encapsulated myoblasts genetically engineered to secrete erythropoietin (Epo) may obviate the need for repeated parenteral administration of recombinant Epo as a treatment for chronic renal failure, cancer or AIDS-associated anemia. To explore this possibility, the human and mouse Epo cD
- Probable intracardiac tuberculoma in an HIV positive woman.
- Heart. 1999 Feb;81(2):181. Unique Identifier : AIDSLINE MED/99130226
- El Saleeby C; Lynn WA; Jayanthi M
- Evaluation of three different commercial procedures for quantifying human immunodeficiency virus type-1 RNA levels.
- New Microbiol. 1999 Jan;22(1):1-9. Unique Identifier : AIDSLINE MED/99206109
- Aschbacher R; Monari P; Lolli S; Donzelli C; Colangeli V; Vignoli M; Ramazzotti E; Furlini G; Re MC; Department of Clinical and Experimental Medicine, University of; Bologna, Italy.
- A branched DNA method for the quantification of human immunodeficiency virus type 1 (HIV-1) RNA levels (Quantiplex HIV RNA 2.0) was compared with a reverse transcriptase-coupled polymerase chain reaction method (Amplicor HIV-1 Monitor) and a nucleic acid sequence-based assay (Nuclisens HIV-1 QT) in plasma samples from
- An abnormally long HIV-1 env DNA PCR product due to altered sequences of primer binding sites.
- New Microbiol. 1999 Jan;22(1):59-62. Unique Identifier : AIDSLINE MED/99206116
- Boriskin YS; Sharland M; Booth JC; Department of Medical Microbiology, St. George's Hospital Medical; School, London, UK.
- To investigate the generation of an abnormally long HIV-1 env PCR DNA product the latter was cloned and sequenced followed by sequence analysis of HIV-1 primer binding sites. We found that the formation of an abnormally long PCR product was due to HIV-1 env sequence alteration (a) in the reverse primer binding site re
- Conformational study of the HIV-1 reverse transcriptase inhibitor 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).
- Biol Chem. 1999 Feb;380(2):265-7. Unique Identifier : AIDSLINE MED/99209809
- Lawtrakul L; Hannongbua S; Beyer A; Wolschann P; Institut fur Theoretische Chemie und Strahlenchemie der; Universitat Wien, Vienna, Austria.
- The conformations of the HIV-1 reverse transcriptase inhibitor 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) are calculated by semiempirical and mainly by ab initio methods in order to estimate the potential for the rotation around the carbon sulfur single bond. The results are compared to X-ray structures
- Morphometric comparison of Chinese-origin and Indian-derived rhesus monkeys (Macaca mulatta).
- Am J Primatol. 1999;47(4):335-46. Unique Identifier : AIDSLINE MED/99221051
- Clarke MR; O'Neil JA; Tulane Regional Primate Research Center, Covington, Louisiana,; USA. mrclarke@mailhost.tcs.tulane.edu
- Chinese-origin and Indian-derived rhesus monkeys (Macaca mulatta), ranging in age from 6 months to 15 years, were weighed and measured during the 1995 inventory of the SAIDS breeding colony at the Tulane Regional Primate Research Center. Data were analyzed separately for males (n=279) and females (n=554), and an analy
- Bovine leukemia virus transmembrane protein gp30 physically associates with the down-regulatory phosphatase SHP-1.
- Unique Identifier : AIDSLINE MED/99240565
- Cantor GH; Pritchard SM; Orlik O; Splitter GA; Davis WC; Reeves R
- In B lymphocytes, the down-regulatory phosphatase SHP-1 associates with CD22 and CD32b (also known as FcgammaRIIB) and acts as a critical negative regulator of B-cell receptor signaling. Bovine leukemia virus, a retrovirus of the HTLV/BLV group, causes persistently increased numbers of peripheral blood B lymphocytes,
- Nitric oxide inhibits the proliferation of T-helper 1 and 2 lymphocytes without reduction in cytokine secretion.
- Cell Immunol. 1999 May 1;193(2):194-201. Unique Identifier : AIDSLINE MED/99240574
- van der Veen RC; Dietlin TA; Pen L; Gray JD; Department of Neurology, University of Southern California School; of Medicine, Los Angeles, California 90033, USA.
- To study the effect of nitric oxide (NO) on the activity of Th subsets, cloned Th1 and Th2 lymphocytes were stimulated in the presence of an NO donor. NO, when present from the start of incubation, inhibited the proliferation of both Th subsets dose-dependently, achieving complete inhibition at a relatively low level.
- Double-blind comparison of fluoxetine and desipramine in the treatment of depressed women with advanced HIV disease: a pilot study.
- Depress Anxiety. 1999;9(2):70-4. Unique Identifier : AIDSLINE MED/99224068
- Schwartz JA; McDaniel JS; Emory University School of Medicine, Department of Psychiatry and; Behavioral Sciences, Grady Health System Infectious Disease; Program, Atlanta, Georgia, USA.
- A double-blind, placebo-controlled study was conducted to assess the relative efficacy and tolerability of fluoxetine and desipramine in depressed, human immunodeficiency virus (HIV)-positive women. Although difficulty in the recruitment and retention of participants led to insufficient power to detect differences bet
- Kaposi's sarcoma: breeding ground of herpesviridae - A tour de force over viral evolution (review).
- Int J Oncol. 1999 Apr;14(4):615-46. Unique Identifier : AIDSLINE MED/99189373
- Sinkovics JG; Horvath JC; Cancer Institute, St. Joseph's Hospital, Tampa, FL 33607, USA.
- After reviewing the molecular biological basis of prominent theories for the integration of viruses into the earliest forms of living matter, an account is given on the immunoevasive strategies viruses have had to acquire in order to secure their existence against the most sophisticated anti-viral defensive mechanisms
- Bone marrow-derived dendritic cells incorporate and process hydrophobized polysaccharide/oncoprotein complex as antigen presenting cells.
- Int J Oncol. 1999 Apr;14(4):695-701. Unique Identifier : AIDSLINE MED/99189380
- Wang L; Ikeda H; Ikuta Y; Schmitt M; Miyahara Y; Takahashi Y; Gu X; Nagata Y; Sasaki Y; Akiyoshi K; Sunamoto J; Nakamura H; Kuribayashi K; Shiku H; 2nd Department of Internal Medicine, Mie University School of; Medicine, Tsu 514-8507, Japan.
- We have previously shown that a novel hydrophobized polysaccharide/oncoprotein complex vaccine can induce immune responses against the HER2/neu/c-erbB2 (HER2) expressing tumors. Bone marrow-derived dendritic cells (DCs), as antigen presenting cells (APCs), are the first candidates for presentation of tumor antigens. T
- HUB1 is an autoantigen frequently eliciting humoral immune response in patients with adult T cell leukemia.
- Int J Oncol. 1999 Apr;14(4):703-8. Unique Identifier : AIDSLINE MED/99189381
- Itoh M; Watanabe M; Yamada Y; Furukawa K; Taniguchi M; Hata T; Schmitt M; Ikeda H; Yamaguchi M; Ohno T; Nakashima K; Shiku H; 2nd Department of Internal Medicine, Mie University School of; Medicine, Tsu, Mie 514-8507, Japan.
- The immunological screening of a cDNA phage expression library prepared from an adult T cell leukemia (ATL) cell line, ST1, was performed with IgG class antibodies in the serum of an ATL patient by the SEREX method to analyze the repertoire of antigen molecules in ATL. Ten different cDNAs, 7 previously reported and 3
- Treatment for common STDs may not always reduce the spread of HIV [news]
- Bull World Health Organ. 1999;77(4):361. Unique Identifier : AIDSLINE MED/99259701
- Shorter short-course treatment protects some infants from HIV [news]
- Bull World Health Organ. 1999;77(4):362. Unique Identifier : AIDSLINE MED/99259703
- AIDS as a lever for reducing inequality and increasing solidarity [letter]
- Bull World Health Organ. 1999;77(4):364. Unique Identifier : AIDSLINE MED/99259705
- Martin J
- GATA-3 significantly downregulates IFN-gamma production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels.
- Clin Immunol. 1999 May;91(2):134-44. Unique Identifier : AIDSLINE MED/99244828
- Ferber IA; Lee HJ; Zonin F; Heath V; Mui A; Arai N; O'Garra A; Department of Immunobiology, DNAX Research Institute of Molecular; and Cellular Biology, 901 California Avenue, Palo Alto,; California 94304, USA.
- IL-12 and IL-4 are dominant factors driving the development of Th1 and Th2 cells, respectively, by their activation of Stat-4 and Stat-6 signaling molecules. Activation of Stat factors, although specific, is a rapid event; however, differentiation of Th cells takes place over several days. Thus, it is unlikely that th
- AIDS update 1999: viral reservoirs and immune-based therapies.
- Cleve Clin J Med. 1999 May;66(5):267-9. Unique Identifier : AIDSLINE MED/99261036
- Isada CM; Calabrese LH; Department of Infectious Disease, Cleveland Clinic Foundation, OH; 44195, USA.
- The advent of highly active antiretroviral therapy (HAART) has brought about a dramatic decline in opportunistic infections, hospitalizations, and mortality in AIDS patients. However, the recent discovery that HIV can lay dormant in quiescent T cells and other tissues even in the face of HAART therapy has dampened opt
- Clearance given for Panretin gel [news]
- Oncologist. 1999;4(2):187. Unique Identifier : AIDSLINE MED/99269684
- Absence of significant Th2 response in diabetes-prone non-obese diabetic (NOD) mice.
- Clin Exp Immunol. 1999 May;116(2):225-30. Unique Identifier : AIDSLINE MED/99271048
- Hartemann AH; Richard MF; Boitard C; U25 INSERM, Necker Hospital and U342 INSERM, Saint Vincent de; Paul Hospital, Paris, France.
- Accumulating evidence suggests that Th1 T cells play a pivotal role in the development of autoimmune diabetes. Conversely, promoting a Th2 response inhibits disease progression. However, it has not been determined whether Th2 cells are regulatory T cells that fail at the time of diabetes development in naive non-diabe
- Early reduction of the over-expression of CD40L, OX40 and Fas on T cells in HIV-1 infection during triple anti-retroviral therapy: possible implications for lymphocyte traffic and functional recovery.
- Clin Exp Immunol. 1999 May;116(2):307-15. Unique Identifier : AIDSLINE MED/99271060
- Sousa AE; Chaves AF; Doroana M; Antunes F; Victorino RM; Cellular Immunology Unit, Centre for Biology and Molecular; Pathology, Faculty of Medicine of Lisbon, Portugal.
- Fas, CD40L and OX40 are members of the tumour necrosis factor (TNF) receptor superfamily with critical roles in T cell activation and death, B cell function, dendritic cell maturation and leucocyte traffic regulation. The aim of this study was to evaluate the effects of anti-retroviral therapy (HAART) on CD40L, OX40 a
- Diminished IL-2 responses and alteration of CD2 expression on CD8+ T cells are associated with a lack of cytotoxic T cell responses during Theileria annulata infection.
- Clin Exp Immunol. 1999 May;116(2):316-21. Unique Identifier : AIDSLINE MED/99271061
- Nichani AK; Craigmile SC; Spooner RL; Campbell JD; Division of Molecular Biology, Roslin Institute (Edinburgh),; Roslin, UK.
- Theileria annulata is a tick-borne protozoan parasite which causes the disease bovine tropical theileriosis. In immunized or drug-treated animals, the pathogenic macroschizont stage of the parasite is destroyed by MHC class I-restricted cytotoxic T lymphocytes (CTL). Here we show that although CD8+ T cells increase gr
- Expression of mucosa-related integrin alphaEbeta7 on alveolar T cells in interstitial lung diseases.
- Clin Exp Immunol. 1999 May;116(2):340-6. Unique Identifier : AIDSLINE MED/99271065
- Lohmeyer J; Friedrich J; Grimminger F; Maus U; Tenter R; Morr H; Velcovsky HG; Seeger W; Rosseau S; Department of Internal Medicine, Justus-Liebig-University,; Giessen, Germany.
- The expression of alphaEbeta7 integrin has been related to the selective retention of lymphocytes in mucosal tissues of gut, urogenital tract and lung. To identify potential disease-associated alphaEbeta7 expression patterns on cells accounting for lymphocytic alveolitis in interstitial lung disease (ILD), alphaE expr
- Antiretroviral therapy for human immunodeficiency virus disease: implications for critical care nursing.
- Crit Care Nurse. 1998 Dec;18(6):54-62. Unique Identifier : AIDSLINE MED/99104669
- Ress BC; HIV Services, Fairmont Hospital, San Leandro, Calif., USA.
- Genetic background determines the nature of immune responses and experimental immune-mediated blepharoconjunctivitis (EC).
- Curr Eye Res. 1999 Feb;18(2):117-24. Unique Identifier : AIDSLINE MED/99238171
- Yoshida O; Yoshida H; Iwamoto H; Nishino K; Fukushima A; Ueno H; Department of Ophthalmology, Kochi Medical School, Japan.
- PURPOSE: Experimental immune-mediated blepharoconjunctivitis (EC) was induced in Lewis rats by immunization with ovalbumin (OVA) in complete Freund s adjuvant (CFA) or aluminum hydroxide [Al(OH)3]. To investigate the affect of genetic factors on the susceptibility of EC, we tested different strains of rats for the dev
- Perioperative blood transfusions: indications and options.
- Chest. 1999 May;115(5 Suppl):113S-121S. Unique Identifier : AIDSLINE MED/99260186
- McFarland JG; Blood Center of Southeastern Wisconsin, Milwaukee 53201-2178,; USA.
- A reevaluation of the indications for and alternatives to transfusion of allogeneic blood was precipitated by transfusion-induced HIV. The transfusion trigger has shifted from an optimal hemoglobin level and hematocrit (10/30) to that level of hemoglobin necessary to meet the patient s tissue oxygen demands. This crit
- T-cell insulitis found in anti-GAD65+ diabetes with residual beta-cell function. A case report [see comments]
- Diabetes Care. 1999 Apr;22(4):615-7. Unique Identifier : AIDSLINE MED/99205539
- Shimada A; Imazu Y; Morinaga S; Funae O; Kasuga A; Atsumi Y; Matsuoka K; Department of Internal Medicine, Saiseikai Central Hospital,; Tokyo, Japan. akirasmd@wa2.so-net.ne.jp
- CASE HISTORY: We recently encountered a 65-year-old anti-GAD+ diabetic woman with residual beta-cell function who was proved to have T-cell insulitis. The proportion of CD4+ and CD8+ cells varied among individual islets, although CD4+ cells tended to be the predominant T-cell type in the islets examined. All of the is
- Managing resistance to anti-HIV drugs: an important consideration for effective disease management.
- Drugs. 1999 Mar;57(3):337-61. Unique Identifier : AIDSLINE MED/99208030
- Vandamme AM; Van Laethem K; De Clercq E; Rega Institute for Medical Research and University Hospitals,; Katholieke Universiteit Leuven, Belgium.; annemie.vandamme@uz.kuleuven.ac.be
- Current recommendations for the treatment of HIV-infected patients advise highly active antiretroviral therapy (HAART) consisting of combinations of 3 or more drugs to provide long-term clinical benefit. This is because only a complete suppression of virus replication will be able to prevent virus drug resistance, the
- Fomivirsen.
- Drugs. 1999 Mar;57(3):375-80; discussion 381. Unique Identifier : AIDSLINE MED/99208032
- Perry CM; Balfour JA; Adis International Limited, Mairangi Bay, Auckland, New Zealand.; demail@adis.co.nz
- Fomivirsen (ISIS 2922) is an antisense oligonucleotide which specifically inhibits replication of human cytomegalovirus . It achieves this by binding to complementary sequences on messenger RNA transcribed from the major immediate-early transcriptional unit of the virus. It is being
- Assessment of the bioavailability of PAHs in rats exposed to a polluted soil by natural routes: induction of EROD activity and DNA adducts and PAH burden in both liver and lung.
- Environ Res. 1999 May;80(4):330-9. Unique Identifier : AIDSLINE MED/99264497
- Fouchecourt MO; Arnold M; Berny P; Videmann B; Rether B; Riviere JL; Unite associee de Toxicologie Metabolique et Ecotoxicologie; INRA-DGER, Marcy l'Etoile, 69280, France.
- In order to assess bioavailability of polycyclic aromatic hydrocarbons (PAHs) present in soils, male laboratory rats were exposed to litters of control and polluted soils. After 88+/-2 h of exposure, several biomarkers were measured in both liver and lung. When rats were exposed to SIV soil, contaminated by a mixture
- Relationship between erythema of the proximal nailfold in HIV-infected patients and hepatitis C virus infection.
- Eur J Clin Microbiol Infect Dis. 1998 Aug;17(8):596-7. Unique Identifier : AIDSLINE MED/99010689
- Courvoisier S; Grob H; Weisser M; Itin PH; Battegay M; Department of Dermatology, University Hospital Basel,; Switzerland.
- Cellular immune responses in mice infected with the intestinal nematode Trichuris muris.
- Exp Parasitol. 1999 May;92(1):40-7. Unique Identifier : AIDSLINE MED/99263457
- Soltys J; Goyal PK; Wakelin D; Parasitological Institute of the Slovak Academy of Sciences,; Hlinkova, Kosice, Slovak Republic, 3, 040 01. uvsjs@montana.edu
- CBA and B10.BR mice show variation in immune response to the intestinal nematode Trichuris muris. CBA mice develop strong resistance, eliminating worms from the intestine; B10BR mice are permissive and develop chronic infections. It is already known that resistance and permissiveness reflect differential T helper resp
- CTAB-mediated enrichment for active forms of novel dimeric maxizymes.
- FEBS Lett. 1999 Apr 1;448(1):67-74. Unique Identifier : AIDSLINE MED/99231764
- Nakayama A; Kuwabara T; Warashina M; Taira K; Institute of Applied Biochemistry, University of Tsukuba, Tsukuba; Science City, Japan.
- We demonstrated previously that shortened forms of (stem II-deleted) hammerhead ribozymes with low intrinsic activity form very active dimers with a common stem II (very active short ribozymes capable of forming dimers were designated maxizymes). As a result of such a dimeric structure, heterodimeric maxizymes are pot
- Octreotide in the treatment of refractory diarrhea.
- Digestion. 1999;60 Suppl 2:42-6. Unique Identifier : AIDSLINE MED/99225448
- Fried M; Department of Gastroenterology, University Hospital, Zurich,; Switzerland. gasfrc@usz.unizh.ch
- Refractory chronic diarrhea that does not respond to specific antimicrobial therapy or standard unspecific medication may present a challenging and serious clinical problem. Octreotide is a candidate drug for the treatment of these patients as it inhibits gastrointestinal motility, pancreatic secretion and inhibits in
- [Nine primitive reflexes in patients with acquired immunodeficiency syndrome (AIDS). Results of a case-control study]
- Gac Med Mex. 1999 Mar-Apr;135(2):101-6. Unique Identifier : AIDSLINE MED/99259729
- Tremont-Lukats IW; Teixeira GM; Hernandez DE; Departamento de Neurologia, Universidad de Wisconsin, Madison,; USA.
- This study estimated the frequency and assessed the clinical value of nine primitive reflexes (PR) in 78 AIDS cases, comparing them with 81 matched, seronegative controls. All subjects were evaluated with a standardized neurologic examination that included a Mini-Mental State Exam (MMSE). Fifty-six percent had cogniti
- [Special "Dr. Ignacio Chavez" lecture. Health and human development]
- Gac Med Mex. 1999 Mar-Apr;135(2):217-30. Unique Identifier : AIDSLINE MED/99259745
- Soberon G
- [Hepatitis B and HIV: the role of the family physician]
- Fortschr Med. 1999 Apr 20;117(11):33. Unique Identifier : AIDSLINE MED/99271277
- Bucklitsch M; Lichte T
- Issues in prison hospice: toward a model for the delivery of hospice care in a correctional setting.
- Hosp J. 1998;13(4):57-82. Unique Identifier : AIDSLINE MED/99099580
- Maull FW; Hospice Program, U.S. Medical Center for Federal Prisoners,; Springfield, MO 65801-4000, USA.
- This paper examines issues in prison hospice care based on the author s nine years experience as a prison hospice worker and trainer and on data gathered by the National Prison Hospice Association (NPHA) from a number of federal and state prison medical facilities with operational or developing hospice programs, inclu
- Proceedings of the 2nd International Summit Meeting on Immunological Correlates of Protection from HIV Infection and Disease. Oxford, United Kingdom, 17-20 April 1998.
- Immunol Lett. 1999 Mar;66(1-3):1-228. Unique Identifier : AIDSLINE MED/99279661
- Detailed immunophenotype of CD8+ memory cytotoxic T-lymphocytes (CTL) against HIV-1 with respect to expression of CD45RA/RO, CD62L and CD28 antigens.
- Immunol Lett. 1999 Mar;66(1-3):105-10. Unique Identifier : AIDSLINE MED/99217691
- Giorgi JV; Hausner MA; Hultin LE; UCLA School of Medicine and the multicenter AIDS Cohort Study,; Los Angeles, CA 90095-1745, USA. giorgi@mednet.ucla.edu
- We have previously reported that circulating effector cytotoxic CD8+ T-lymphocytes (CTLs) against HIV-1 express CD38 and HLA-DR activation antigens. In this study, we performed two series of FACS sorts to phenotype and characterize precursors of CTL effectors. First we looked at memory CTL activity against HIV-1 stimu
- Subpopulations of peripheral blood dendritic cells show differential susceptibility to infection with a lymphotropic strain of HIV-1.
- Immunol Lett. 1999 Mar;66(1-3):111-6. Unique Identifier : AIDSLINE MED/99217692
- Patterson S; Robinson SP; English NR; Knight SC; Antigen Presentation Research Group, Imperial College School of; Medicine at Northwick Park, Institute for Medical Research,; Harrow, Middlesex, UK. s.patterson@ic.ac.uk
- Blood dendritic cells (DC) express CD4 and are susceptible to HIV infection. By electron microscopy two morphologically distinct types of DC were identified in peripheral blood. Only one of these two types was susceptible to infection with a lymphotropic strain of HIV-1. By FACS two populations could be defined based
- Rational reconstitution of the immune repertoire in AIDS with autologous, antigen-specific, in vitro-expanded CD4 lymphocytes.
- Immunol Lett. 1999 Mar;66(1-3):117-20. Unique Identifier : AIDSLINE MED/99217693
- Manca F; Fenoglio D; Li Pira G; Gennari F; Del Pup L; Palu G; Unit of Retroviral Immunology, Advanced Biotechnology Centre,; Genoa, Italy. manca@sirio.cba.unige.it
- HIV infection leads to decrease of CD4 lymphocytes. In particular, loss of CD4 cells specific for opportunistic pathogens results in active opportunistic infections, that are the chief cause of morbidity and mortality in AIDS. Highly active anti-retroviral therapy (HAART) has been shown to have dramatic effects in a l
- Dendritic cells generated from blood monocytes of HIV-1 patients are not infected and act as competent antigen presenting cells eliciting potent T-cell responses.
- Immunol Lett. 1999 Mar;66(1-3):121-8. Unique Identifier : AIDSLINE MED/99217694
- Sapp M; Engelmayer J; Larsson M; Granelli-Piperno A; Steinman R; Bhardwaj N; The Laboratory of Cellular Physiology and Immunology, The; Rockefeller University, New York, NY 10021, USA.
- The CTL response to HIV-I can be vigorous, but antigen presenting cell requirements have not been studied in detail. To approach this question, we have examined the dendritic cell populations that can be obtained from the blood of HIV-1 infected individuals. We studied 13 asymptomatic patients, who spanned a wide rang
- Antigen presenting cell function in HIV-1 infected patients.
- Immunol Lett. 1999 Mar;66(1-3):129-34. Unique Identifier : AIDSLINE MED/99217695
- Fidler SJ; Rees AD; Department Genito-Urinary Medicine and Communicable Diseases,; Imperial College, School of Medicine at St Mary's Hospital,; London, UK.
- Antigen presenting cell (APC) function is central to the activation of anti-viral cytotoxic T-cells and antibody production. In previous studies we have evaluated APC function in HIV-1 infected patients as the capacity to present peptide to a well defined panel of CD4 T-cell clones. We found that APC from HIV-1 infect
- Comparison of restimulation methods to elicit SIV specific cytotoxic T-lymphocytes (CTL) in vitro: Staphylococcal enterotoxin B (SEB) provides a novel method for the quantification of SIV specific CTL precursors.
- Immunol Lett. 1999 Mar;66(1-3):135-40. Unique Identifier : AIDSLINE MED/99217696
- Kakimoto WM; Gettie A; Smith S; Donahoe SM; Jin X; Marx P; Connor R; Nixon DF; The Aaron Diamond AIDS Research Center, The Rockefeller; University, New York, NY 10016, USA.
- Most investigators believe that an effective HIV-1 vaccine will have to induce high levels of HIV-1 specific cytotoxic T-cells (CTL). The macaque SIV challenge/protection model system has been used to test candidate vaccines, but quantitative immunogenicity measurements are difficult due to technical limitations of th
- Antibody neutralization of HIV-1 and the potential for vaccine design.
- Unique Identifier : AIDSLINE MED/99217697
- Sattentau QJ; Moulard M; Brivet B; Botto F; Guillemot JC; Mondor I; Poignard P; Ugolini S
- Neutralisation by antibody is, for a number of viruses, an in vitro correlate for protection in vivo. For HIV-1 this is controversial. However, the induction of a potent anti-HIV neutralising antibody response remains one of the principal goals in vaccine development. A greater knowledge of the fundamental mechanisms
- Cellular immunity and target cell susceptibility in persons with repeated HIV-1 exposure.
- Immunol Lett. 1999 Mar;66(1-3):15-9. Unique Identifier : AIDSLINE MED/99217679
- Akridge R; Hladik F; Markee J; Alef C; Kelley H; Collier A; Collier A; McElrath MJ; The Department of Laboratory Medicine, the University of; Washington School of Medicine, Seattle, USA.
- We prospectively studied 37 HIV-1 uninfected persons engaging in repeated high risk sexual activity with an HIV-1 infected partner, as well as 18 of their infected partners. Only one subject (3%) demonstrated the homozygous 32-bp deletion delta32delta32 of the HIV-1 co-receptor CCR5. CD4+ cells from all high risk subj
- Suppression of human immunodeficiency virus type 1 replication by a soluble factor produced by CD8+ lymphocytes from HIV-2-infected baboons.
- Immunol Lett. 1999 Mar;66(1-3):151-7. Unique Identifier : AIDSLINE MED/99217698
- Locher CP; Blackbourn DJ; Levy JA; Department of Medicine, University of California, San Francisco; 94143-1270, USA. locher@itsa.ucsf.edu
- Human immunodeficiency virus type 2 (HIV-2)-infected baboons (Papio cynocephalus) provide a valuable animal model for the study of acquired immunodefidency syndrome (AIDS) pathogenesis since many features of disease progression resemble HIV-1-infection of humans. In some HIV-2-infected baboons that are clinically heal
- The implications of antigenic diversity for vaccine development.
- Immunol Lett. 1999 Mar;66(1-3):159-64. Unique Identifier : AIDSLINE MED/99217699
- Zolla-Pazner S; Gomy MK; Nyambi PN; Research Center for AIDS and HIV Infection, New York Veterans; Affairs Medical Center, NY 10010, USA.; zollas01@mcrcr6.med.nyu.edu
- The reactivity of human monoclonal and polyclonal anti-HIV-1 antibodies demonstrates that shared epitopes, including those that induce neutralizing antibodies, exist and are recognized by the human immune system. A priori, there is no reason why cross-clade neutralizing antibodies could not be induced by an appropriat
- Live attenuated SIV--a model of a vaccine for AIDS.
- Unique Identifier : AIDSLINE MED/99217700
- Almond N; Stott J; Division of Retrovirology, National Institute for Biological; Standards & Control, Potters Bar, Herts., UK. nalmond@nibsc.ac.uk
- The experimental infection of macaques with simian immunodeficiency virus (SIV) has provided strong evidence that it may be possible to develop a vaccine against AIDS. Live attenuated SIV vaccines have been found to confer the most potent protection against challenge with a variety of pathogenic viruses. This article
- CD8-suppressor factor and beta-chemokine function as a complementary mechanism to cognate immunity.
- Immunol Lett. 1999 Mar;66(1-3):171-6. Unique Identifier : AIDSLINE MED/99217701
- Lehner T; Wang Y; Tao L; Bergmeier LA; Mitchell E; Doyle C; Department of Immunology, United Medical, School of Guy's; Hospital, London, UK. t.lehner@umds.ac.uk
- Protection against SIV or HIV infection requires specific antibodies and T-cell immune responses. However, a complementary mechanism may be involved, in which CD8-suppressor factors (CD8-SF) and the constitutive beta-chemokines may prevent the virus binding and replicating. Indeed, there is evidence that targeted ilia
- Pre-clinical development of a multi-CTL epitope-based DNA prime MVA boost vaccine for AIDS.
- Immunol Lett. 1999 Mar;66(1-3):177-81. Unique Identifier : AIDSLINE MED/99217702
- Hanke T; McMichael A; Institute of Molecular Medicine, University of Oxford, The John; Radcliffe Hospital, UK. hanke@molbiol.ox.ac.uk
- Reliable and effective methods for induction of cytotoxic T-lymphocytes (CTL) are constantly persued. Central to this search is work in animal models, which allow to test novel vaccine strategies and ultimately lead to a more efficient planning of clinical trials. Here, human immunodeficiency virus (HIV) vaccine candi
- Protection from pathogenic SIV challenge using multigenic DNA vaccines.
- Immunol Lett. 1999 Mar;66(1-3):183-8. Unique Identifier : AIDSLINE MED/99217703
- Haigwood NL; Pierce CC; Robertson MN; Watson AJ; Montefiori DC; Rabin M; Lynch JB; Kuller L; Thompson J; Morton WR; Benveniste RE; Hu SL; Greenberg P; Mossman SP; Seattle Biomedical Research Institute, WA 98109, USA.; haigwood@u.washington.edu
- To assess DNA immunization as a strategy for protecting against HIV infection in humans, we utilized SIVmne infection of Macaca fascicularis as a vaccine challenge model with moderate pathogenic potential. We compared the efficacy of DNA immunization alone and in combination with subunit protein boosts. All of the str
- HIV-1 vaccine-induced immune responses which correlate with protection from SHIV infection: compiled preclinical efficacy data from trials with ten different HIV-1 vaccine candidates.
- Immunol Lett. 1999 Mar;66(1-3):189-95. Unique Identifier : AIDSLINE MED/99217704
- Heeney J; Akerblom L; Barnett S; Bogers W; Davis D; Fuller D; Koopman G; Lehner T; Mooij P; Morein B; de Giuli Morghen C; Rosenwirth B; Verschoor E; Wagner R; Wolf H; Department of Virology, Biomedical Primate Research Centre,; Rijswijk, The Netherlands. heeney@bprc.nl
- The specific immune mechanisms necessary and/or sufficient to elicit HIV-vaccine protection remain undefined. Utilising the SHIV rhesus macaque model the immunogenicity as well as the efficacy of ten different HIV-1 vaccine candidates was evaluated. Comparison of the immune responses induced, with the ability of the v
- 'Naive' and 'memory' CD4+ T-cells and T-cell receptor (TCR) V beta repertoire dynamics are independent of the levels of viremia following HIV seroconversion.
- Immunol Lett. 1999 Mar;66(1-3):199-206. Unique Identifier : AIDSLINE MED/99217705
- King DJ; Amjadi P; Tilling R; Kinloch-de-Loes S; Loveday C; Johnson MA; Janossy G; Tarragona A; Gotch F; Larsson-Sciard EL; Department of Immunology, ICSM, Chelsea and Westminster Hospital,; London, UK.
- The progression of naive and memory T-cells and the T-cell receptor Vbeta (TCR Vbeta) repertoire dynamics within the peripheral CD4+ T-cell compartment were studied in individuals following HIV seroconversion. Profound TCR Vbeta repertoire perturbations were observed within the CD4+ T-cell pool in treatment-naive
- Restoration of the immune system with anti-retroviral therapy.
- Immunol Lett. 1999 Mar;66(1-3):207-11. Unique Identifier : AIDSLINE MED/99217706
- Autran B; Carcelaint G; Li TS; Gorochov G; Blanc C; Renaud M; Durali M; Mathez D; Calvez V; Leibowitch J; Katlama C; Debre P; Laboratoire d'Immunologie Cellulaire et Tissulaire, UMR CNRS; 7627, Hopital Pitie-Salpetriere, Paris, France.
- Clinical benefits of highly active anti-retroviral treatments (HAART) are increasingly evidenced by resolving opportunistic infections and malignancies, as well as declining hospitalization and mortality rates [1]. This suggests that potent and sustained suppression of viral replication, at least to some extent, is as
- A role for mucosal immunity in resistance to HIV infection.
- Immunol Lett. 1999 Mar;66(1-3):21-5. Unique Identifier : AIDSLINE MED/99217680
- Clerici M; Salvi A; Trabattoni D; Lo Caputo S; Semplici F; Biasin M; Ble C; Meacci F; Romeo C; Piconi S; Mazzotta F; Villa ML; Mazzoli S; Cattedra di Immunologia, Universita di Milano, Milan, Italy.; mago@imiucca.csi.unimi.it
- In a recent, thought-provoking novel by Elizabeth McCracken (The Giant s House. Avon Books, New York, 1997), two characters discuss love and its impossibilities. One brashly claims to be immune to love , explaining the concept to his perplexed interlocutor, ...people become immune to love like they become immune to
- Antigen-specific T-lymphocyte proliferative responses during highly active antiretroviral therapy (HAART) of HIV-1 infection.
- Immunol Lett. 1999 Mar;66(1-3):213-7. Unique Identifier : AIDSLINE MED/99217707
- Pontesilli O; Kerkhof-Garde S; Pakker NG; Notermans DW; Roos MT; Klein MR; Danner SA; Miedema F; Department of Clinical Viro-Immunology, University of Amsterdam,; The Netherlands. pontesilli@vira.fgg.eur.nl
- To evaluate functional T-cell recovery during combination therapy with ritonavir , lamivudine ( 3TC ), and zidovudine (ZDV), peripheral
- Molecular tracking of an Human Immunodeficiency Virus nef specific cytotoxic T-cell clone shows persistence of clone-specific T-cell receptor DNA but not mRNA following early combination antiretroviral therapy.
- Immunol Lett. 1999 Mar;66(1-3):219-28. Unique Identifier : AIDSLINE MED/99217708
- Nixon DF; Douek D; Kuebler PJ; Jin X; Vesanen M; Bonhoeffer S; Cao Y; Koup RA; Ho DD; Markowitz M; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, NY 10016, USA. dnixon@adarc.org
- The mechanisms that lead to maintenance of an active effector cytotoxic T-cell (CTL) response in Human Immunodeficiency Virus type-1 (HIV-1) infection are not well understood. We have investigated the role of antigen in maintenance of an HIV-1 specific CTL response by studying a patient (313-7) whose antigenic stimulu
- Resistance to HIV-1 infection among highly exposed sex workers in Nairobi: what mediates protection and why does it develop?
- Immunol Lett. 1999 Mar;66(1-3):27-34. Unique Identifier : AIDSLINE MED/99217681
- Plummer FA; Ball TB; Kimani J; Fowke KR; Department of Medical Microbiology, University of Nairobi, Kenya.; plummer@form-net.com
- Variability in susceptibility to infection and disease caused by infectious agents is a characteristic of all populations. Among susceptible individuals exposed to an infection, not all become infected and among infected individuals, not all develop disease. It seems logical that variability in susceptibility to infec
- Control mechanisms of virus replication in naturally SIVsmm infected mangabeys and experimentally infected macaques.
- Immunol Lett. 1999 Mar;66(1-3):37-46. Unique Identifier : AIDSLINE MED/99217682
- Villinger F; Brice GT; Mayne A; Bostik P; Ansari AA; Winship Cancer, Department of Pathology and Laboratory Medicine,; Emory University School of Medicine, Atlanta, GA 30322, USA.; fvillin@emory.edu
- As a close cousin to Asian macaques, the African sooty mangabey monkey, a species naturally infected with SIV without ever developing disease, represents an intriguing and thought provoking model for the study of lentiviral infection and disease development. Pursuant to our previous findings that documented the presen
- Why are the natural hosts of SIV resistant to AIDS?
- Immunol Lett. 1999 Mar;66(1-3):47-52. Unique Identifier : AIDSLINE MED/99217683
- Norley S; Beer B; Holzammer S; zur Megede J; Kurth R; Paul-Ehrlich-Institute, Langen, Germany. norst@pei.de
- An increasing number of African primate species have been shown to be infected in the wild with their own distinct variants of simian immunodeficiency virus. The most striking feature of these natural host systems is the lack of AIDS-like disease despite long-term infection. In the African green monkey (AGM)/SIVagm sy
- Rapid and slow progressors differ by a single MHC class I haplotype in a family of MHC-defined rhesus macaques infected with SIV.
- Immunol Lett. 1999 Mar;66(1-3):53-9. Unique Identifier : AIDSLINE MED/99217684
- Evans DT; Knapp LA; Jing P; Mitchen JL; Dykhuizen M; Montefiori DC; Pauza CD; Watkins DI; Wisconsin Regional Primate Research Center, University of; Wisconsin, Madison 53715, USA.
- Highly polymorphic HLA class I molecules may influence rates of disease progression of HIV-infected individuals. Recent evidence suggests that individuals who mount vigorous CTL responses to multiple HIV-1 epitopes have reduced viral loads, and survive longer than individuals that make a less robust or less diverse CT
- Differential cytotoxic T-lymphocyte (CTL) responses in HIV-1 immunised sibling chimpanzees with shared MHC haplotypes.
- Immunol Lett. 1999 Mar;66(1-3):61-7. Unique Identifier : AIDSLINE MED/99217685
- Balla-Jhagjhoorsingh S; Mooij P; Koopman G; Haaksma T; Teeuwsen V; Heeney J; Bontrop R; Department of Virology, Biomedical Primate Research Centre,; Rijswijk, Netherlands.
- Cell mediated immune responses to HIV-1 and CTL responses in particular differ dramatically in infected individuals. This may largely be influenced by the immunogenetic differences of different individuals such as those encoded by the MHC. These differences may be difficult to dissect due to the immunosuppressive natu
- HIV-1 infectability of CD4+ lymphocytes with relation to beta-chemokines and the CCR5 coreceptor.
- Immunol Lett. 1999 Mar;66(1-3):71-5. Unique Identifier : AIDSLINE MED/99217686
- Paxton WA; Kang S; Liu R; Landau NR; Gingeras TR; Wu L; Mackay CR; Koup RA; Department of Human Retrovirology, Academic Medical Center,; University of Amsterdam, Netherlands. w.a.paxton@amc.uva.nl
- CD4+ lymphocytes exhibit variable permissiveness to the replication of HIV-1. A cohort of sexually-exposed-yet-uninfected individuals were previously shown to have CD4+ lymphocytes refractory for M-tropic viral replication. In particular, two individuals from this population whose CD4+ lymphocytes exhibited complete r
- Quantitation of antigen-specific CD8+ T-cell responses.
- Immunol Lett. 1999 Mar;66(1-3):77-80. Unique Identifier : AIDSLINE MED/99217687
- Ogg GS; McMichael AJ; Molecular Immunology, Institute of Molecular Medicine, Oxford,; UK. gogg@worf.molbiol.ox.ac.uk
- Enumeration of antigen-specific CD8+ T-cells has traditionally been largely dependent on the use of techniques that require a period of expansion in vitro. However the recent emergence of methods that can be used directly ex vivo to quantify antigen-specific CD8+ T cells has prompted a re-evaluation of the magnitude o
- The role of HIV gp120 in the disruption of the immune system.
- Immunol Lett. 1999 Mar;66(1-3):81-7. Unique Identifier : AIDSLINE MED/99217688
- Dalgleish AG; Marriott JB; Souberbielle B; Montesano C; Sheikh J; Sidebottom D; Westby M; Austen B; Department of Oncology, St. George's Hospital Medical School,; London, UK. dalgleis@sghms.ac.uk
- The existence of HIV positive individuals who do not appear to progress to disease, or do so only very slowly (LTNPs), strongly suggest that factors other than virus pathogenicity determine disease. The occurence of HIV infected chimpanzees that remain disease free and other African SIV infected primates where disease
- Characterization of HIV-1-specific T-helper cells in acute and chronic infection.
- Immunol Lett. 1999 Mar;66(1-3):89-93. Unique Identifier : AIDSLINE MED/99217689
- Rosenberg ES; LaRosa L; Flynn T; Robbins G; Walker BD; Partners AIDS Research Center and Infectious Disease Unit,; Massachusetts General Hospital and Harvard Medical School, Boston; 02114, USA.
- HIV-1 infection is associated with progressive and relentless destruction of the immune system in the majority of infected persons, but some persons appear to be able to successfully contain the virus in the absence of antiviral therapy. Such cases suggest that the host immune response can successfully contain the vir
- Broadly cross-reactive HIV-specific cytotoxic T-lymphocytes in highly-exposed persistently seronegative donors.
- Immunol Lett. 1999 Mar;66(1-3):9-14. Unique Identifier : AIDSLINE MED/99217678
- Rowland-Jones SL; Dong T; Dorrell L; Ogg G; Hansasuta P; Krausa P; Kimani J; Sabally S; Ariyoshi K; Oyugi J; MacDonald KS; Bwayo J; Whittle H; Plummer FA; McMichael AJ; Molecular Immunology Group, Institute of Molecular Medicine, John; Radcliffe Hospital, Oxford, UK. sarah.rowland-jones@ndm.ox.ac.uk
- HIV-specific cytotoxic T-lymphocytes (CTL) are believed to play a key part in the control of virus levels throughout HIV infection. An important goal of a potential prophylactic vaccine against HIV is therefore to elicit a strong CTL response which is broadly cross-reactive against a diverse range of HIV strains. We h
- Apoptosis and the CD95 system in HIV disease: impact of highly active anti-retroviral therapy (HAART).
- Immunol Lett. 1999 Mar;66(1-3):97-103. Unique Identifier : AIDSLINE MED/99217690
- Gougeon ML; Lecoeur H; Sasaki Y; Departement SIDA et Retrovirus, Institut Pasteur, Paris, France.; mlgougeo@pasteur.fr
- Apoptosis markers and the rate of lymphocyte apoptosis were followed in the peripheral blood of HIV infected persons at various stages of disease. Our study suggests that the early increase in memory cells following therapy may also be due to a significant decrease in apoptosis in this subset. The intrinsic resistance
- Increasing prevalence of dual HIV-1-2 infections among voluntary blood donors in Mumbai (Bombay).
- Indian J Med Sci. 1998 Dec;52(12):548-52. Unique Identifier : AIDSLINE MED/99259777
- Kamat HA; Banker DD; Koppikar GV; Department of Pathology, Sir Hurkisondas Nurrotumdas Hospital,; Mumbai.
- Between 1993 and 1996, we carried out a serological screening for differentially identifying HIV-1 and HIV-2 infections among the high risk group persons admitted in the various wards of BYL Nair Hospital, Mumbai, using the ImmunoComb kit. This study indicates that although HIV-1 is the predominant virus prevalent in
- DNA aptamers selected against the HIV-1 trans-activation-responsive RNA element form RNA-DNA kissing complexes.
- J Biol Chem. 1999 Apr 30;274(18):12730-7. Unique Identifier : AIDSLINE MED/99230299
- Boiziau C; Dausse E; Yurchenko L; Toulme JJ; INSERM U 386, IFR Pathologies Infectieuses, Universite Victor; Segalen, 146 rue Leo Saignat, F-33076 Bordeaux Cedex, France.
- In vitro selection was performed in a DNA library, made of oligonucleotides with a 30-nucleotide random sequence, to identify ligands of the human immunodeficiency virus type-1 trans-activation-responsive (TAR) RNA element. Aptamers, extracted after 15 rounds of selection-amplification, either from a classical library
- Inhibition of Ets-1 DNA binding and ternary complex formation between Ets-1, NF-kappaB, and DNA by a designed DNA-binding ligand.
- J Biol Chem. 1999 Apr 30;274(18):12765-73. Unique Identifier : AIDSLINE MED/99230304
- Dickinson LA; Trauger JW; Baird EE; Dervan PB; Graves BJ; Gottesfeld JM; Department of Molecular Biology, The Scripps Research Institute,; La Jolla, California 92037, USA.
- Sequence-specific pyrrole-imidazole polyamides can be designed to interfere with transcription factor binding and to regulate gene expression, both in vitro and in living cells. Polyamides bound adjacent to the recognition sites for TBP, Ets-1, and LEF-1 in the human immunodeficiency virus, type 1 (HIV-1), long termin
- Regulation of the human interleukin-5 promoter by Ets transcription factors. Ets1 and Ets2, but not Elf-1, cooperate with GATA3 and HTLV-I Tax1.
- J Biol Chem. 1999 Apr 30;274(18):12910-6. Unique Identifier : AIDSLINE MED/99230324
- Blumenthal SG; Aichele G; Wirth T; Czernilofsky AP; Nordheim A; Dittmer J; Institut fur Zellbiologie, Abteilung Molekularbiologie,; Universitat Tubingen, Auf der Morgenstelle 15, 72076 Tubingen,; Germany.
- Interleukin-5 (IL-5), expressed primarily by type-2 T helper (Th2) cells, plays an important role in the development of allergic diseases, such as allergic asthma. Studying the regulation of IL-5 gene expression by Ets transcription factors, we found that Ets1 and Ets2, but not Elf-1, were able to activate the human I
- Nuclear IkappaBbeta maintains persistent NF-kappaB activation in HIV-1-infected myeloid cells.
- J Biol Chem. 1999 May 7;274(19):13010-6. Unique Identifier : AIDSLINE MED/99240678
- DeLuca C; Petropoulos L; Zmeureanu D; Hiscott J; Lady Davis Institute for Medical Research, Sir Mortimer B. Davis; Jewish General Hospital, McGill University, Montreal, Quebec H3T; 1E2, Canada.
- Monocytic cells exhibit constitutive NF-kappaB activation upon infection with human immunodeficiency virus-1 (HIV-1). Because IkappaBbeta has been implicated in maintaining NF-kappaB.DNA binding, we sought to investigate whether IkappaBbeta was involved in maintaining persistent NF-kappaB activation in HIV-1-infected
- Antibiotic troubleshooting in primary care.
- Hosp Pract (Off Ed). 1999 May 15;34(5):95-101. Unique Identifier : AIDSLINE MED/99271395
- Czachor JS; Division of Infectious Diseases, Wright State University School; of Medicine, Dayton, Ohio, USA.
- Allergic reactions, adverse effects, and drug interactions are an inevitable part of antimicrobial prescribing. A working knowledge of these issues remains paramount, especially when administering such agents to patients who are pregnant, infected with HIV, or who have renal insufficiency. The discussion also includes
- Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis.
- J Clin Invest. 1999 Apr;103(8):1103-11. Unique Identifier : AIDSLINE MED/99225524
- Spergel JM; Mizoguchi E; Oettgen H; Bhan AK; Geha RS; Division of Immunology, Children's Hospital, Harvard Medical; School, Boston, Massachusetts 02115, USA.
- Skin lesions in atopic dermatitis (AD) are characterized by hypertrophy of the dermis and epidermis, infiltration by T cells and eosinophils, and expression of the cytokines IL-4, IL-5, and IFN-gamma. The role of these cytokines in the pathogenesis of AD is not known. We took advantage of a recently described murine m
- Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice.
- J Clin Invest. 1999 Apr;103(8):1201-9. Unique Identifier : AIDSLINE MED/99225535
- Amrani A; Verdaguer J; Anderson B; Utsugi T; Bou S; Santamaria P; Department of Microbiology and Infectious Diseases, Faculty of; Medicine, The University of Calgary, Calgary, Alberta, Canada T2N; 4N1.
- Autoimmune diabetes in nonobese diabetic (NOD) mice results from destruction of pancreatic beta cells by T lymphocytes. It is believed that CD8(+) cytotoxic T lymphocytes (CTLs) effect the initial beta-cell insult in diabetes, but the mechanisms remain unclear. Studies of NOD.lpr mice have suggested that disease initi
- Distribution of 14 high risk HPV types in cervical intraepithelial neoplasia detected by a non-radioactive general primer PCR mediated enzyme immunoassay.
- J Clin Pathol. 1999 Jan;52(1):17-22. Unique Identifier : AIDSLINE MED/99275075
- Nindl I; Lotz B; Kuhne-Heid R; Endisch U; Schneider A; Department of Gynaecology, Friedrich Schiller University, Jena,; Germany. nindl@bach.med.uni-jena.de
- AIM: To evaluate the presence of high risk human papillomaviruses (HPV) in cervical smears showing intraepithelial neoplasia (CIN). METHODS: The presence of 14 high risk HPV was evaluated in 114 cervical smears with CIN of different degrees, by comparing a non-radioactive polymerase chain reaction (PCR) enzyme immunoa
- Infection by Rhodococcus equi in a patient with AIDS: histological appearance mimicking Whipple's disease and Mycobacterium avium-intracellulare infection.
- J Clin Pathol. 1999 Jan;52(1):68-71. Unique Identifier : AIDSLINE MED/99275084
- Hamrock D; Azmi FH; O'Donnell E; Gunning WT; Philips ER; Zaher A; Department of Pathology, Medical College of Ohio, Toledo 43614,; USA.
- Rhodococcus equi pneumonia with systemic dissemination is being reported increasingly in immunocompromised patients. This is the first case report of disseminated R equi infection with biopsy documented involvement of the large intestine. The patient was a 46 year old male with AIDS who was diagnosed with cavitating p
- Does valproate pose a threat to human immunodeficiency virus-infected patients? [letter]
- J Clin Psychopharmacol. 1999 Apr;19(2):189-90. Unique Identifier : AIDSLINE MED/99226908
- Hardy MA; Nardacci D
- Production of IL-4 and expression of CD40 ligand by human CD8 T cells.
- J Allergy Clin Immunol. 1999 May;103(5 Pt 2):S405-11. Unique Identifier : AIDSLINE MED/99262577
- Yanagihara Y; Kajiwara K; Koshio T; Basaki Y; Ikizawa K; Mori M; Akiyama K; Kawamura N; Sakiyama Y; Clinical Research Center for Allergy, National Sagamihara; Hospital, Sagamihara, Japan.
- BACKGROUND: The role of CD8(+) T cells in IgE synthesis remains unclear. OBJECTIVE: The aim of this study was to investigate IL-4 production and CD40 ligand expression by human CD8(+) T cells. METHODS: We conducted functional and phenotypic analyses of human T cells in peritoneal washings from severe combined immunode
- Characteristics of T-cell receptor Valpha24JalphaQ T cells, a human counterpart of murine NK1 T cells, from normal subjects.
- J Allergy Clin Immunol. 1999 May;103(5 Pt 2):S445-51. Unique Identifier : AIDSLINE MED/99262582
- Sakamoto A; Oishi Y; Kurasawa K; Kita Y; Saito Y; Iwamoto I; Department of Internal Medicine II, Chiba University School of; Medicine, Chiba, Japan.
- BACKGROUND: In mice, natural killer (NK) T cells are specialized subsets of T cells that express an invariate T cell receptor (TCR) alpha chain and NK markers. In particular, murine NK1(+/-) T cells rapidly produce IL-4 and function as regulatory T cells. OBJECTIVE: We investigated the distribution of invariate TCR Va
- Receptors and cytokines involved in allergic TH2 cell responses.
- J Allergy Clin Immunol. 1999 May;103(5 Pt 2):S492-6. Unique Identifier : AIDSLINE MED/99262588
- de Vries JE; Carballido JM; Aversa G; Novartis Research Institute, Vienna, Austria.
- Cytokines produced by allergen-specific TH2 cells play a central role in the induction and maintenance of allergic responses. Therefore antagonizing TH2 differentiation and TH2 effector functions will provide an effective way to intervene in allergic diseases. This article discusses that antagonizing the effects of IL
- [Images. Severe infections]
- J Fr Ophtalmol. 1999 Mar;22(2):268. Unique Identifier : AIDSLINE MED/99259337
- HIV-1 Infection, Mucosal Immunity and Pathogenesis. Conference proceedings. Bethesda, Maryland, USA. 11-13 September 1997.
- J Infect Dis. 1999 May;179 Suppl 3:S391-498. Unique Identifier : AIDSLINE MED/99279667
- Human immunodeficiency virus type 1 infection, mucosal immunity, and pathogenesis and extramural research programs at the National Institutes of Health.
- J Infect Dis. 1999 May;179 Suppl 3:S392-6. Unique Identifier : AIDSLINE MED/99201443
- Kresina TF; Mathieson B; Division of Digestive Diseases and Nutrition, National Institute; of Diabetes and Digestive and Kidney Diseases, National; Institutes of Health, Bethesda, MD 20892-6600, USA. tk13v@nih.gov
- Human immunodeficiency virus type 1 infection, mucosal immunity, and pathogenesis: comments and conference summary.
- J Infect Dis. 1999 May;179 Suppl 3:S397-400. Unique Identifier : AIDSLINE MED/99201444
- Wahl SM; Smith PD; Janoff EN; Oral Infection and Immunity Branch, National Institute of Dental; Research, National Institutes of Health, Bethesda, MD 20892, USA.; smwahl@yoda.nidr.nih.gov
- Studies of human immunodeficiency virus type 1 mucosal viral shedding and transmission in Kenya.
- J Infect Dis. 1999 May;179 Suppl 3:S401-4. Unique Identifier : AIDSLINE MED/99201445
- Overbaugh J; Kreiss J; Poss M; Lewis P; Mostad S; John G; Nduati R; Mbori-Ngacha D; Martin Jr H; Richardson B; Jackson S; Neilson J; Long EM; Panteleeff D; Welch M; Rakwar J; Jackson D; Chohan B; Lavreys L; Mandaliya K; Ndinya-Achola J; Bwayo J; Program in Molecular Medicine, Fred Hutchinson Cancer Research; Center, Seattle, WA 98109-1024, USA. joverbau@fhcrc.org.; joverbau@fhcrc.org
- If human immunodeficiency virus type 1 (HIV-1) vaccines are to be highly effective, it is essential to understand the virologic factors that contribute to HIV-1 transmission. It is likely that transmission is determined, in part, by the genotype or phenotype (or both) of infectious virus present in the index case, whi
- Transmission of human immunodeficiency virus type 1 through breast-feeding: how can it be prevented?
- J Infect Dis. 1999 May;179 Suppl 3:S405-7. Unique Identifier : AIDSLINE MED/99201446
- Van de Perre P; Centre Muraz, Organisation de Coordination et de Cooperation pour; la Lutte contre les Grandes Endemies, Bobo-Dioulasso, Burkina; Faso. direction.muraz@fasonet.bf
- One-third to two-thirds of maternal transmission of human immunodeficiency virus type 1 (HIV-1) infection to breast-fed infants can be attributed to ingestion of breast milk. The presence of HIV-1 as cell-free and as cell-associated virus in milk has been documented. Several substances in breast milk may be protective
- Oral transmission of primate lentiviruses.
- J Infect Dis. 1999 May;179 Suppl 3:S408-12. Unique Identifier : AIDSLINE MED/99201447
- Ruprecht RM; Baba TW; Liska V; Ray NB; Martin LN; Murphey-Corb M; Rizvi TA; Bernacky BJ; Keeling ME; McClure HM; Andersen J; Laboratory of Viral Pathogenesis, Dana-Farber Cancer Institute,; Boston, MA 02115, USA. ruth_ruprecht@dfci.harvard.edu
- Oral transmission of human immunodeficiency virus type 1 (HIV-1) is well documented in children who become infected postnatally through breast milk. In contrast, epidemiologic surveys have yielded conflicting data regarding oral HIV-1 transmission among adults, even though case reports have described seroconversion an
- T cell-tropic simian immunodeficiency virus (SIV) and simian-human immunodeficiency viruses are readily transmitted by vaginal inoculation of rhesus macaques, and Langerhans' cells of the female genital tract are infected with SIV.
- J Infect Dis. 1999 May;179 Suppl 3:S413-7. Unique Identifier : AIDSLINE MED/99201448
- Miller CJ; Hu J; Virology and Immunology Unit, California Regional Primate; Research Center, University of California Davis, Davis, CA 95616,; USA. cjmiller@ucdavis.edu
- Intravaginal inoculation with T cell-tropic molecular clones of simian immunodeficiency virus (SIV) or simian-human immunodeficiency virus (SHIV) or some dual-tropic strains of SIV or SHIV produced systemic infection in rhesus macaques. Vaginal inoculation with other dual-tropic molecular clones of SIV or SHIV did not
- Rectal transmission of human immunodeficiency virus type 1 to chimpanzees.
- J Infect Dis. 1999 May;179 Suppl 3:S418-21. Unique Identifier : AIDSLINE MED/99201449
- Fultz PN; Wei Q; Yue L; Department of Microbiology, University of Alabama School of; Medicine, Birmingham, AL 35294, USA. pnf@uab.edu
- Inoculation of chimpanzees with human immunodeficiency virus type 1 (HIV-1) has been used as a model system to define mechanisms of pathogenesis and to test protective efficacy of candidate HIV-1 vaccines. In most of these studies, the animals were inoculated intravenously. However, because HIV-1 is transmitted primar
- Cofactors for human immunodeficiency virus entry into primary macrophages.
- J Infect Dis. 1999 May;179 Suppl 3:S422-6. Unique Identifier : AIDSLINE MED/99201450
- Collman RG; Yi Y; Pulmonary and Critical Care Division, University of Pennsylvania; School of Medicine, Philadelphia, PA 19104-6060, USA.; collmanr@mail. med.upenn.edu
- Macrophages are permissive for macrophage-tropic (M-tropic) human immunodeficiency virus type 1 (HIV-1) isolates that use CCR5 for entry but are resistant to CXCR-4-dependent T cell-tropic prototype strains. M-tropic variants are critical for HIV-1 transmission, and persons who are homozygous for an inactivating mutat
- Mucosal dendritic cells and immunodeficiency viruses.
- J Infect Dis. 1999 May;179 Suppl 3:S427-30. Unique Identifier : AIDSLINE MED/99201451
- Pope M; Laboratory of Cellular Physiology and Immunology, The Rockefeller; University, New York, NY 10021, USA.; popem@rockvax.rockefeller.edu
- Dendritic cells [DCs] have been implicated in the pathogenesis of human immunodeficiency virus type 1 (HIV-1). When skin was used as a model for mucosae, the cutaneous DC-T cell milieu allowed the growth of HIV-1 and much of the newly produced virus could be detected in multinucleated DC-T cell syncytia. Such virus re
- Endogenous mucosal antiviral factors of the oral cavity.
- J Infect Dis. 1999 May;179 Suppl 3:S431-5. Unique Identifier : AIDSLINE MED/99201452
- Shugars DC; Departments of Dental Ecology and of Microbiology and Immunology,; Schools of Dentistry and Medicine, University of North Carolina; at Chapel Hill, Chapel Hill, NC 27599-7455, USA.; diane_shugars@dentistry.unc.edu
- The oral cavity represents a unique site for mucosal transmission of human immunodeficiency virus type 1 (HIV-1). Unlike other mucosal sites, the oral cavity is rarely a site of HIV transmission despite detectable virus in saliva and oropharyngeal tissues of infected persons. One reason for this apparent paradox is th
- Mucosal events in the pathogenesis of human immunodeficiency virus type 1 infection.
- J Infect Dis. 1999 May;179 Suppl 3:S436-40. Unique Identifier : AIDSLINE MED/99201453
- Smith PD; Li L; Meng G; Department of Medicine (Gastroenterology and Hepatology),; University of Alabama at Birmingham School of Medicine,; Birmingham, AL 35294, USA.
- The interaction between human immunodeficiency virus type 1 (HIV-1) and primary mucosal cells isolated from normal human small intestine was investigated. Purified primary intestinal epithelial cells could transport cell-free HIV-1 to mononuclear cells, although the epithelial cells did not support viral replication.
- Interactions of viruses and microparticles with apical plasma membranes of M cells: implications for human immunodeficiency virus transmission.
- J Infect Dis. 1999 May;179 Suppl 3:S441-3. Unique Identifier : AIDSLINE MED/99201454
- Neutra MR; Department of Pediatrics, Harvard Medical School, and GI Cell; Biology Laboratory, Children's Hospital, Boston, MA 02115, USA.; neutra_m@a1.tch.harvard.edu
- In the rectal mucosa, specialized M cells of the lymphoid follicle-associated epithelium conduct vesicular transport of antigens from the mucosal surface into organized mucosal lymphoid tissues, where immune responses are induced. Bacteria and viruses may exploit this mechanism to initiate mucosal or systemic infectio
- Human immunodeficiency virus type 1 (HIV-1) infection and expression in intestinal epithelial cells: role of protein kinase A and C pathways in HIV-1 transcription.
- J Infect Dis. 1999 May;179 Suppl 3:S444-7. Unique Identifier : AIDSLINE MED/99201455
- Kagnoff MF; Roebuck KA; Department of Medicine, University of California, San Diego, La; Jolla, CA 92093-0623, USA. mkagnoff@ucsd.edu
- Human immunodeficiency virus (HIV) can infect human colon epithelial cell lines by both CD4-dependent and -independent mechanisms. The present studies assessed cellular factors that are important for HIV-1 transcription in human colon epithelial cells. The HIV-1 long terminal repeat (LTR) was shown to contain function
- Infectious human immunodeficiency virus can rapidly penetrate a tight human epithelial barrier by transcytosis in a process impaired by mucosal immunoglobulins.
- J Infect Dis. 1999 May;179 Suppl 3:S448-53. Unique Identifier : AIDSLINE MED/99201456
- Hocini H; Bomsel M; U. 332-Institut Cochin de Genetique Moleculaire, 22, rue; Mechain F-75014, Paris, France.
- Mucosal surfaces are the main natural site of entry into the body for human immunodeficiency virus (HIV). Herein, an alternative mechanism for virus spread is described. The mechanism, which involves transcytosis of endosome-internalized HIV-particles, was generated by contact of HIV-infected cells with the apical sur
- Characterization of intestinal disease associated with human immunodeficiency virus infection and response to antiretroviral therapy.
- J Infect Dis. 1999 May;179 Suppl 3:S454-6. Unique Identifier : AIDSLINE MED/99201457
- Kotler DP; Gastrointestinal Division, Department of Medicine, St. Luke's-; Roosevelt Hospital Center, College of Physicians and Surgeons,; Columbia University, New York, NY 10025, USA. dpkotler@aol.com
- Combination antiretroviral therapies suppress human immunodeficiency virus (HIV) in peripheral blood, but the effect in gastrointestinal mucosa is uncertain. The occurrence of pathogen-negative diarrhea led to speculation that local HIV infection is etiologic. Mucosal cellular reservoirs for HIV were documented by use
- Co-infection with opportunistic pathogens promotes human immunodeficiency virus type 1 infection in macrophages.
- J Infect Dis. 1999 May;179 Suppl 3:S457-60. Unique Identifier : AIDSLINE MED/99201458
- Wahl SM; Greenwell-Wild T; Peng G; Hale-Donze H; Orenstein JM; Oral Infection and Immunity Branch, National Institute of Dental; Research, National Institutes of Health, Bethesda, MD 20892-4352,; USA. smwahl@yoda.nidr.nih.gov.
- Human immunodeficiency virus type 1 (HIV-1) infection is dependent on susceptible host cells that express both CD4 and chemokine co-receptors. The co-receptor CCR5 is associated with primary infection by macrophage-tropic virus isolates, whereas CXCR4 is commonly associated with T cell- and dual-tropic viruses. Once i
- The pathophysiology of disseminated Mycobacterium avium complex disease in AIDS.
- J Infect Dis. 1999 May;179 Suppl 3:S461-5. Unique Identifier : AIDSLINE MED/99201459
- Horsburgh Jr CR; Division of Infectious Diseases, Department of Medicine, Emory; University, Atlanta, GA 30303, USA. rhorsbu@sph.emory.edu
- Mycobacterium avium complex (MAC) organisms cause disseminated disease in patients with AIDS. The organisms penetrate the gastrointestinal mucosa by unknown mechanisms and are phagocytosed by macrophages in the lamina propria. These cells cannot kill the organisms, and MAC spreads through the submucosal tissue. Lympha
- Immunity to rotavirus infection in mice.
- J Infect Dis. 1999 May;179 Suppl 3:S466-9. Unique Identifier : AIDSLINE MED/99201460
- Franco MA; Greenberg HB; Instituto de Genetica, Facultad de Medicina, Pontifica; UniversidadJaverina, Bogota, Columbia. angelfranco@openway.com.co
- Recent findings from our laboratory regarding the immune response of mice to rotavirus (a mucosal pathogen) show that although in most situations an acquired (T or B cell or both) response is necessary for elimination of primary rotavirus infection, unidentified innate mechanisms can also play a role in some mouse str
- Mucosal immune system of the human genital tract.
- J Infect Dis. 1999 May;179 Suppl 3:S470-4. Unique Identifier : AIDSLINE MED/99201461
- Mestecky J; Fultz PN; Departments of Microbiology, University of Alabama at Birmingham,; Birmingham, AL 35294-2170, USA. mestecky@uab.edu
- In contrast to the pronounced dominance of secretory IgA over other immunoglobulin isotypes in human saliva, tears, milk, and gastrointestinal fluids, secretions of both female and male genital tracts contain more IgG than secretory IgA. Both IgG and IgA are derived, to a variable degree, from the systemic immunoglobu
- Human immunodeficiency virus type 1 and mucosal humoral defense.
- J Infect Dis. 1999 May;179 Suppl 3:S475-9. Unique Identifier : AIDSLINE MED/99201462
- Janoff EN; Scamurra RW; Sanneman TC; Eidman K; Thurn JR; Infectious Disease Section, Department of Medicine and Research; Service, University of Minnesota School of Medicine, VA Medical; Center, Minneapolis, MN 55417, USA. janof001@maroon.tc.umn.edu
- Mucosal sites serve as the principle venues through which primary human immunodeficiency virus type 1 (HIV-1) infections are transferred from donor to host. These moist tissues, which provide the interface with the external environment, also provide access to many of the secondary opportunistic infections that aggrava
- Mucosal Th1- versus Th2-type responses for antibody- or cell-mediated immunity to simian immunodeficiency virus in rhesus macaques.
- J Infect Dis. 1999 May;179 Suppl 3:S480-4. Unique Identifier : AIDSLINE MED/99201463
- McGhee JR; Kiyono H; Kubota M; Kawabata S; Miller CJ; Lehner T; Imaoka K; Fujihashi K; Immunobiology Vaccine Center and Departments of Oral Biology and; Microbiology, University of Alabama at Birmingham, Birmingham, AL; 35294-2170, USA. mcghee@uab.edu
- Simian immunodeficiency virus (SIV)-specific B cell responses and the Th1- or Th2-type profiles of cytokine expression were determined for rhesus macaques immunized with SIV antigens via the iliac lymph nodes (by use of a targeted lymph node [TLN] procedure) or orally with SIV p55gag plus cholera toxin (CT) as a mucos
- CD8+ cell-derived anti-human immunodeficiency virus inhibitory factor.
- J Infect Dis. 1999 May;179 Suppl 3:S485-8. Unique Identifier : AIDSLINE MED/99201464
- Barker E; Department of Microbiology and Immunology, SUNY Health Science; Center, Syracuse, NY 13210, USA. barkere@vax.cs.hscsyr.edu; barkere@vax.cs.hscsyr.edu
- CD8+ cells in human immunodeficiency virus (HIV)-infected individuals develop the ability to control HIV replication not only by destruction of the infected cells but also by controlling the virus in a noncytotoxic fashion that leaves the infected cell functionally intact. The CD8+ noncytotoxic response is mediated by
- The effect of route of immunization on mucosal immunity and protection.
- J Infect Dis. 1999 May;179 Suppl 3:S489-92. Unique Identifier : AIDSLINE MED/99201465
- Lehner T; Wang Y; Ping L; Bergmeier L; Mitchell E; Cranage M; Hall G; Dennis M; Cook N; Doyle C; Jones I; Department of Immunobiology, United Medical and Dental Schools at; Guy's Hospital, London, SE1 9RT, United Kingdom.; t.lehner@umds.ac.uk
- In macaques, the route of immunization has a profound effect on the immune response. Augmenting rectal or vaginal immunization with oral or nasal immunization enhanced the secretory IgA, serum IgG, and T cell responses. However, targeted iliac lymph node (TILN) immunization with recombinant simian immunodeficiency vir
- Mucosal vaccination strategies for women.
- J Infect Dis. 1999 May;179 Suppl 3:S493-8. Unique Identifier : AIDSLINE MED/99201466
- Kozlowski PA; Cu-Uvin S; Neutra MR; Flanigan TP; Children's Hospital, Boston, MA 02115, USA.; kozlowski@a1.tch.harvard. edu
- Women were immunized orally, rectally, or vaginally with a recombinant cholera toxin B-containing vaccine to determine which of these mucosal immunization routes generate the greatest levels of antibody in the female genital tract and rectum. ELISA was used to measure concentrations of cholera toxin B-specific IgA and
- [Investigation of a new p24 antigen detection system by the chemiluminescence-enzyme-immuno-assay]
- Kansenshogaku Zasshi. 1999 Mar;73(3):205-12. Unique Identifier : AIDSLINE MED/99239171
- Sakai A; Hirabayashi Y; Aizawa S; Tanaka M; Ida S; Oka S; AIDS Clinical Center, International Medical Center of Japan.
- We investigated a new p24 antigen detection system by the chemiluminescence-enzyme-immuno-assay (CLEIA) and compared it with the conventional antigen-kits (A; Abbott, B; Coulter). The detection limit of CLEIA, A, and B were 4.3 pg/ml, 11.3 pg/ml, and 5.6 pg/ml, respectively. When the patient s sera and panel sera were
- Effects of complementarity determining region mutations on the affinity of an alpha/beta T cell receptor: measuring the energy associated with CD4/CD8 repertoire skewing.
- J Exp Med. 1999 Feb 1;189(3):461-70. Unique Identifier : AIDSLINE MED/99126473
- Manning TC; Parke EA; Teyton L; Kranz DM; Department of Biochemistry, University of Illinois, Urbana,; Illinois 61801, USA.
- It has been proposed that the generally low affinities of T cell receptors (TCRs) for their peptide-major histocompatibility complex (pMHC) ligands (Kd approximately 10(-4) to 10(-7) M) are the result of biological selection rather than an intrinsic affinity limitation imposed by the TCR framework. Using a soluble ver
- Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor beta1 and beta2 chain expression.
- J Exp Med. 1999 Feb 1;189(3):541-52. Unique Identifier : AIDSLINE MED/99126481
- Braun MC; He J; Wu CY; Kelsall BL; Immune Cell Interaction Unit, Mucosal Immunity Section, National; Institutes of Allergy and Infectious Disease, National Institutes; of Health, Bethesda, Maryland 20892, USA.
- Cholera toxin (CT) is a potent mucosal vaccine adjuvant, which has been shown to induce T helper cell type 2 (Th2) responses in systemic and mucosal tissues. We report that CT inhibits the production of interleukin (IL)-12, a major Th2 counterregulatory cytokine. IL-12 p70 production by stimulated human monocytes was
- The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
- J Exp Med. 1999 Feb 1;189(3):563-74. Unique Identifier : AIDSLINE MED/99126483
- Di Santo JP; Aifantis I; Rosmaraki E; Garcia C; Feinberg J; Fehling HJ; Fischer A; von Boehmer H; Rocha B; Institut National de la Sante et de la Recherche Medicale; (INSERM) U429, Hopital Necker-Enfants Malades, F-75743 Paris,; France. disanto@nexker.fr
- Intracellular signals emanating from cytokine and antigen receptors are integrated during the process of intrathymic development. Still, the relative contributions of cytokine receptor signaling to pre-T cell receptor (TCR) and TCR-mediated differentiation remain undefined. Interleukin (IL)-7 interactions with its cog
- CD8alpha+ and CD8alpha- subclasses of dendritic cells direct the development of distinct T helper cells in vivo.
- J Exp Med. 1999 Feb 1;189(3):587-92. Unique Identifier : AIDSLINE MED/99126485
- Maldonado-Lopez R; De Smedt T; Michel P; Godfroid J; Pajak B; Heirman C; Thielemans K; Leo O; Urbain J; Moser M; Departement de Biologie Moleculaire, Universite Libre de; Bruxelles, B-1640 Rhode-Saint-Genese, Belgium.
- Cells of the dendritic family display some unique properties that confer to them the capacity to sensitize naive T cells in vitro and in vivo. In the mouse, two subclasses of dendritic cells (DCs) have been described that differ by their CD8alpha expression and their localization in lymphoid organs. The physiologic fu
- Antigen-pulsed CD8alpha+ dendritic cells generate an immune response after subcutaneous injection without homing to the draining lymph node.
- Unique Identifier : AIDSLINE MED/99126486
- Smith AL; de St Groth BF; Centenary Institute of Cancer Medicine and Cell Biology, Newtown,; New South Wales, Australia, 2042.
- Two subsets of murine splenic dendritic cells, derived from distinct precursors, can be distinguished by surface expression of CD8alpha homodimers. The functions of the two subsets remain controversial, although it has been suggested that the lymphoid-derived (CD8alpha+) subset induces tolerance, whereas the myeloid-d
- Cytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity.
- J Exp Med. 1999 Mar 1;189(5):779-86. Unique Identifier : AIDSLINE MED/99160624
- Kehren J; Desvignes C; Krasteva M; Ducluzeau MT; Assossou O; Horand F; Hahne M; Kagi D; Kaiserlian D; Nicolas JF; Institut National de la Sante et de la Recherche Medicale; (INSERM) U503, Faculte Laennec, F-69372 Lyon Cedex 08, France.
- Contact hypersensitivity (CHS) is a T cell-mediated skin inflammation induced by epicutaneous exposure to haptens in sensitized individuals. We have previously reported that CHS to dinitrofluorobenzene in mice is mediated by major histocompatibility complex (MHC) class I-restricted CD8(+) T cells. In this study, we sh
- T helper cell type 1-associated and cytotoxic T lymphocyte-mediated tumor immunity is impaired in interleukin 4-deficient mice.
- J Exp Med. 1999 Mar 1;189(5):803-10. Unique Identifier : AIDSLINE MED/99160627
- Schuler T; Qin Z; Ibe S; Noben-Trauth N; Blankenstein T; Max-Delbruck-Center for Molecular Medicine, 13122 Berlin,; Germany. tschue@mdc-berlin.de
- It is widely accepted that cellular immune responses are induced by CD4(+) T helper 1 (Th1) cells secreting interleukin (IL)-2 and interferon (IFN)-gamma. Tumor immunity is often mediated by cytotoxic T lymphocytes (CTLs) whose activation is supported by Th1 cytokines. Since IL-4 directs Th2 development and has been s
- Maturation, activation, and protection of dendritic cells induced by double-stranded RNA.
- J Exp Med. 1999 Mar 1;189(5):821-9. Unique Identifier : AIDSLINE MED/99160629
- Cella M; Salio M; Sakakibara Y; Langen H; Julkunen I; Lanzavecchia A; Basel Institute for Immunology, CH-4005 Basel, Switzerland.; cella@bii.ch
- The initiation of an immune response is critically dependent on the activation of dendritic cells (DCs). This process is triggered by surface receptors specific for inflammatory cytokines or for conserved patterns characteristic of infectious agents. Here we show that human DCs are activated by influenza virus infecti
- Peripheral autoantigen induces regulatory T cells that prevent autoimmunity.
- J Exp Med. 1999 Mar 1;189(5):877-82. Unique Identifier : AIDSLINE MED/99160635
- Seddon B; Mason D; Medical Research Council Cellular Immunology Unit, Sir William; Dunn School of Pathology, University of Oxford, Oxford OX1 3RE,; United Kingdom. bseddon@nimr.mrc.ac.uk
- Previous studies have shown that autoimmune thyroiditis can be induced in normal laboratory rats after thymectomy and split dose gamma-irradiation. Development of disease can be prevented by reconstitution of PVG rats shortly after their final irradiation with either peripheral CD4(+)CD45RC- T cells or CD4(+)CD8(-) th
- Nigerian university students' knowledge, perceptions, and behaviours about HIV/AIDS: are these students at risk?
- J R Soc Health. 1999 Mar;119(1):23-31. Unique Identifier : AIDSLINE MED/99259795
- Harding AK; Anadu EC; Gray LA; Champeau DA; Oregon State University, Corvallis 97331-6406, USA.
- The purpose of the study was to determine the knowledge level of undergraduate students of a Nigerian university about HIV/AIDS, their perception of risk of contracting HIV/AIDS based on their sexual behaviour, and to assess how students acquire information about HIV/AIDS. The sample consisted of 380 students from fiv
- SQ: a program for rapidly producing pharmacophorically relevent molecular superpositions.
- J Med Chem. 1999 May 6;42(9):1505-14. Unique Identifier : AIDSLINE MED/99248221
- Miller MD; Sheridan RP; Kearsley SK; Department of Molecular Systems, Merck Research Laboratories,; Sumneytown Pike, West Point, Pennsylvania 19486, USA.
- A new method SQ has been developed to provide fast, automatic, and objective pairwise three-dimensional molecular alignments. SQ uses an atom-based clique-matching step followed by an alignment scoring function that has been parametrized to recognize pharmacologically relevant atomic properties. Molecular alignments f
- cycloSal-Pronucleotides of 2',3'-dideoxyadenosine and 2', 3'-dideoxy-2',3'-didehydroadenosine: synthesis and antiviral evaluation of a highly efficient nucleotide delivery system.
- J Med Chem. 1999 May 6;42(9):1604-14. Unique Identifier : AIDSLINE MED/99248229
- Meier C; Knispel T; De Clercq E; Balzarini J; Institute of Organic Chemistry, Julius-Maximilians-University; Wurzburg, Am Hubland, D-97074 Wurzburg, Germany.
- The synthesis, hydrolysis, and antiviral evaluation of novel, lipophilic cycloSal-ddAMP (9a-d) and cycloSal-d4AMP (10a-d) derivatives of the antiviral purine dideoxynucleoside analogues 2 , 3 -dideoxyadenosine (ddA) (2) and 2 ,3 -dideoxy-2 , 3 -didehydroadenosine (d4A) (3) are reported. These potential pronucleotides
- cycloSal-Pronucleotides of 2'-fluoro-ara- and 2'-fluoro-ribo-2',3'- dideoxyadenosine as a strategy to bypass a metabolic blockade.
- J Med Chem. 1999 May 6;42(9):1615-24. Unique Identifier : AIDSLINE MED/99248230
- Meier C; Knispel T; Marquez VE; Siddiqui MA; De Clercq E; Balzarini J; Institute of Organic Chemistry, Julius-Maximilians-University; Wurzburg, Am Hubland, D-97074 Wurzburg, Germany.
- Novel, lipophilic cycloSal triesters 4a-c and 5a-c were synthesized, respectively, from the ara- and ribo-configurated 2 -fluorinated-2 , 3 -dideoxyadenosines 2 and 3. The cycloSal phosphotriesters were used as tools to study the effects of the two different sugar pucker conformations induced by two opposite configura
- Immunohistochemical localization of retroviral-related antigens expressed in normal baboon placental villous tissue.
- J Med Primatol. 1998 Dec;27(6):278-86. Unique Identifier : AIDSLINE MED/99217657
- Langat DK; Johnson PM; Rote NS; Wango EO; Owiti GO; Mwenda JM; Institute of Primate Research, Karen, Nairobi, Kenya.
- Endogenous retroviral particles (ERVs) have been detected in the genome of all eukaryotes. They are generally non-pathogenic except in mice where they have been found to induce tumors and immunological disorders. The ERVs have morphological features consistent with type-C retroviral particles and are commonly expresse
- Structure/function analysis of a dUTPase: catalytic mechanism of a potential chemotherapeutic target.
- J Mol Biol. 1999 Apr 30;288(2):275-87. Unique Identifier : AIDSLINE MED/99263535
- Harris JM; McIntosh EM; Muscat GE; Centre for Molecular and Cellular Biology, University of; Queensland, St Lucia, Australia. jharris@biosci.uq.oz.au
- dUTP pyrophosphatase catalyses hydrolysis of deoxyuridine triphosphate (dUTP) to deoxyuridine monophosphate (dUMP) and inorganic pyrophosphate (PPi). Elimination of dUTP is vital since its misincorporation into DNA by DNA polymerases can initiate a damaging iterative repair and misincorporation cycle, resulting in DNA
- Drug doings Down Under [news]
- JAMA. 1999 May 19;281(19):1782-3. Unique Identifier : AIDSLINE MED/99270171
- Swan N
- The clinical effectiveness and cost-effectiveness of screening for anal squamous intraepithelial lesions in homosexual and bisexual HIV-positive men.
- JAMA. 1999 May 19;281(19):1822-9. Unique Identifier : AIDSLINE MED/99270195
- Goldie SJ; Kuntz KM; Weinstein MC; Freedberg KA; Welton ML; Palefsky JM; Center for Risk Analysis, Department of Health Policy and; Management, Harvard School of Public Health, Boston, Mass; 02115-5924, USA. sgoldie@hsph.harvard.edu
- CONTEXT: Homosexual and bisexual men infected with human immunodeficiency virus (HIV) are at increased risk for human papillomavirus-related anal neoplasia and anal squamous cell carcinoma (SCC). OBJECTIVE: To estimate the clinical benefits and cost-effectiveness of screening HIV-positive homosexual and bisexual men f
- Prophylactic cesarean delivery for the prevention of perinatal human immunodeficiency virus transmission: the case for restraint.
- Unique Identifier : AIDSLINE MED/99277403
- Stringer JS
- [Anti-HIV-1 genes; genetic restriction of AIDS pathogenesis by gene variants]
- Nippon Rinsho. 1999 Apr;57(4):967-74. Unique Identifier : AIDSLINE MED/99239304
- Tashiro K; Ikegawa M; Yabe D; Honjo T; Center for Molecular Biology and Genetics, Kyoto University.
- Three genes which have variants acting as anti-HIV-1 were described so far. Among three, two are genes encoding receptors for chemokines, namely CCR5 and CCR2, which act as entry coreceptors for HIV-1 virus. The other gene is SDF1 gene. SDF-1, a cytokine belonging to the chemokine family has an inhibitory activity aga
- Mycobacterium avium-intracellulare pulmonary infection in patients without known predisposing lung disease.
- Lung. 1998;176(6):381-91. Unique Identifier : AIDSLINE MED/98453492
- Kubo K; Yamazaki Y; Hachiya T; Hayasaka M; Honda T; Hasegawa M; Sone S; Department of Medicine, Shinshu University School of Medicine,; Matsumoto 390-8621, Japan.
- We tried to characterize the clinical features and findings on chest high resolution computed tomography (HRCT) of patients with Mycobacterium avium-intracellulare (MAI) pulmonary infection without known predisposing lung disease and with no immunodeficiency. We also aimed to clarify the small airway and alveolar infl
- Treatments for wasting in patients with the acquired immunodeficiency syndrome.
- N Engl J Med. 1999 Jun 3;340(22):1740-50. Unique Identifier : AIDSLINE MED/99260707
- Corcoran C; Grinspoon S; Neuroendocrine Unit, Massachusetts General Hospital, and Harvard; Medical School, Boston 02114, USA.
- Naturally attenuated HIV--lessons for AIDS vaccines and treatment [editorial; comment]
- N Engl J Med. 1999 Jun 3;340(22):1756-7. Unique Identifier : AIDSLINE MED/99260710
- Collins KL; Nabel GJ
- Resolution of chronic hepatitis B after ritonavir treatment in an HIV-infected patient [letter]
- N Engl J Med. 1999 Jun 3;340(22):1765-6. Unique Identifier : AIDSLINE MED/99260719
- Velasco M; Moran A; Tellez MJ
- Tat, a human immunodeficiency virus-1-derived protein, augments excitotoxic hippocampal injury in neonatal rats.
- Neuroscience. 1999 Jan;88(2):585-97. Unique Identifier : AIDSLINE MED/99211634
- Wang P; Barks JD; Silverstein FS; Department of Pediatrics, University of Michigan, Ann Arbor; 48109-0646, USA.
- To test the hypothesis that the human immunodeficiency virus-1-derived Tat protein may cause neuronal damage in the CNS, we evaluated the neurotoxicity of recombinant human immunodeficiency virus-1-derived Tat in vivo in seven-day-old rats. The intrinsic neurotoxicity of Tat (250 ng-1 microg) and the effects of direct
- Combined treatment with zidovudine, lamivudine, nelfinavir and ganciclovir in an infant with human immunodeficiency virus type 1 infection and cytomegalovirus encephalitis: case report and review of the literature.
- Pediatr Infect Dis J. 1999 Apr;18(4):382-6. Unique Identifier : AIDSLINE MED/99238213
- Rohrer T; Rinaldi D; Bubl R; Engelcke G; Di Gallo A; Rudin C; University Children's Hospital, University of Basel, Switzerland.
- Hypopigmented mycosis fungoides associated with human T cell lymphotropic virus type I tax in a pediatric patient.
- Pediatrics. 1999 May;103(5 Pt 1):1039-45. Unique Identifier : AIDSLINE MED/99240860
- Zucker-Franklin D; Kosann MK; Pancake BA; Ramsay DL; Soter NA; Departments of Medicine and Dermatology, New York University; Medical Center, New York, NY 10016, USA.
- Measles immunization in HIV-infected children. American Academy of Pediatrics. Committee on Infectious Diseases and Committee on Pediatric AIDS.
- Pediatrics. 1999 May;103(5 Pt 1):1057-60. Unique Identifier : AIDSLINE MED/99240865
- Children infected with human immunodeficiency virus (HIV) have had high rates of mortality attributable to measles, but until recently, measles vaccine was assumed to be safe for these children. A single fatal case of pneumonia attributable to vaccine type-measles virus has been documented in a young adult with acquir
- The core of caregiving [editorial; comment]
- Nurs Res. 1999 May-Jun;48(3):119. Unique Identifier : AIDSLINE MED/99268164
- Gennaro S
- Diagnosis disclosure by family caregivers to children who have perinatally acquired HIV disease: when the time comes [see comments]
- Nurs Res. 1999 May-Jun;48(3):141-9. Unique Identifier : AIDSLINE MED/99268167
- Ledlie SW; International Center of Research for Women, Children, and; Families, University of Pennsylvania, School of Nursing,; Philadelphia, USA. sledlie@ibm.net
- BACKGROUND: Children with perinatally acquired HIV disease (PAHD) can be relatively symptom-free and live to school age and older. These children often confront their caregivers with questions about the illness and complex treatments; however, caregivers may try to avoid disclosing the diagnosis of PAHD to the child.
- Do blacks believe that HIV/AIDS is a government conspiracy against them?
- Prev Med. 1999 May;28(5):451-7. Unique Identifier : AIDSLINE MED/99263091
- Klonoff EA; Landrine H; Behavioral Health Institute, California State University, 5500; University Parkway, San Bernardino, California 92407, USA.; eklonoff@csusb.edu
- BACKGROUND: We present the first study to explore the possibility that blacks believe that the human immunodeficiency virus was developed by the federal government in order to exterminate the black population. METHODS: Five hundred twenty black adults sampled door to door in 10 randomly selected census tracts complete
- [Epidemiology and transmission of HIV infection]
- Pharm Unserer Zeit. 1999 Mar;28(2):95-101. Unique Identifier : AIDSLINE MED/99237389
- Rockstroh JK; Medizinische Universitatsklinik, Bonn.
- Intracranial mass lesions: sequential thallium and gallium scintigraphy in patients with AIDS.
- Radiology. 1999 May;211(2):507-12. Unique Identifier : AIDSLINE MED/99245219
- Lee VW; Antonacci V; Tilak S; Fuller JD; Cooley TP; Department of Radiology, Boston University School of Medicine,; Boston Medical Center, MA 02118, USA.
- PURPOSE: To determine the efficacy of sequential thallium and gallium scintigraphy to differentiate intracranial neoplasms (lymphoma and glioma) from other nonmalignant intracranial mass lesions among patients with acquired immunodeficiency syndrome (AIDS). MATERIALS AND METHODS: The authors reviewed the cases of 40 p
- [Infectious diseases in 1998]
- Rev Med Interne. 1999 Apr;20(4):365-8. Unique Identifier : AIDSLINE MED/99259466
- Bricaire F; Service des maladies infectieuses, hopital de la; Pitie-Salpetriere, Paris, France.
- AIDS windfall [news]
- Science. 1999 May 7;284(5416):885. Unique Identifier : AIDSLINE MED/99283821
- Uses and abuses of Tuskegee.
- Science. 1999 May 7;284(5416):919-21. Unique Identifier : AIDSLINE MED/99283833
- Fairchild AL; Bayer R; Program in the History of Public Health and Medicine, Division of; Sociomedical Sciences, The Joseph L. Mailman School of Public; Health, Columbia University, New York, NY 10032-2625, USA.; alf4@columbia.edu
- Gastro-intestinal Kaposi's sarcoma, with special reference to the appendix.
- S Afr J Surg. 1999 Feb;37(1):9-11. Unique Identifier : AIDSLINE MED/99239308
- Chetty R; Arendse MP; Department of Anatomical Pathology, University of Natal, Durban.
- Kaposi s sarcoma (KS) of the gastro-intestinal tract is a common disease in the AIDS setting, although it is often asymptomatic. In this paper we wish to highlight the occurrence of gastro-intestinal KS with appendiceal involvement. Two of the patients presented with features of acute appendicitis, and KS of the appen
- The mother-to-child HIV transmission debate [letter]
- S Afr Med J. 1999 Feb;89(2):103-4. Unique Identifier : AIDSLINE MED/99207571
- Hussey G; Fransman D; McGillivray G; Reynolds L; Jacobs M; Power D; Burgess J; Eley B; Woods D; Coetzee N; Coetzee E; Anthony J; Maartens G; Schaaf S; Cotton M; Theron G
- The mother-to-child HIV transmission debate [letter]
- S Afr Med J. 1999 Feb;89(2):104-5. Unique Identifier : AIDSLINE MED/99277325
- Beyers N; Cotton MF; Donald PR; Gie RP; Henning PA; Hesseling PB; Kirsten GF; Kling S; Nel ED; Pieper CH; Ravenscroft A; Schaaf HS; Schoeman JF; Smith J; van Buuren AJ; van der Merwe PL; van Schalkwyk HJ; Wessels G
- The mother-to-child HIV transmission debate [letter]
- S Afr Med J. 1999 Feb;89(2):106. Unique Identifier : AIDSLINE MED/99207573
- Joubert JR; Beale MW
- National Institute of Virology report on testing of Virodene by the NIV [letter]
- S Afr Med J. 1999 Feb;89(2):108-9. Unique Identifier : AIDSLINE MED/99207575
- Sequeira WL; Visser MO; Leeuw YJ
- Tell all on Virodene [news]
- S Afr Med J. 1999 Feb;89(2):113. Unique Identifier : AIDSLINE MED/99207578
- Jones JS
- Virodene down but not out [news]
- S Afr Med J. 1999 Feb;89(2):116, 118. Unique Identifier : AIDSLINE MED/99207579
- Jones JS
- Should AIDS be notifiable? [editorial]
- S Afr Med J. 1999 Feb;89(2):147-8. Unique Identifier : AIDSLINE MED/99207590
- Colvin M
- Eight years of tuberculosis research in Hlabisa--what have we learned?
- S Afr Med J. 1999 Feb;89(2):155-9. Unique Identifier : AIDSLINE MED/99207592
- Wilkinson D; Medical Research Council, Centre for Epidemiological Research,; Southern Africa.
- An 8-year research-service collaboration in tuberculosis (TB) in Hlabisa has yielded important data on the emerging HIV-related TB epidemic in South Africa , demonstrating a substantial increase in caseload, HIV prevalence and mortality. A successful, cost-effective, community-base
- Medical ethics--promoting AIDS? [letter]
- S Afr Med J. 1999 Mar;89(3):216, 218. Unique Identifier : AIDSLINE MED/99243248
- Collins WG
- AIDS and informed consent [letter]
- S Afr Med J. 1999 Mar;89(3):218, 220. Unique Identifier : AIDSLINE MED/99243249
- Edge B
- Health planning for the AIDS epidemic [letter]
- S Afr Med J. 1999 Mar;89(3):220. Unique Identifier : AIDSLINE MED/99243250
- Mahomed FA
- South African tuberculosis mortality data--showing the first sign of the AIDS epidemic?
- S Afr Med J. 1999 Mar;89(3):269-73. Unique Identifier : AIDSLINE MED/99243259
- Kleinschmidt I
- OBJECTIVE: To report on the magnitude and distribution of registered tuberculosis (TB) mortality rates in South Africa for 1994 and 1995 in the context of changes in overall mortality registration. DESIGN: Retrospective analysis of routinely collected data. SETTING: The South Afri
- HIV and acute disseminated encephalomyelitis [letter]
- S Afr Med J. 1999 Mar;89(3):283-4. Unique Identifier : AIDSLINE MED/99243262
- Bhigjee AI; Patel VB; Bhagwan B; Moodley AA; Bill PL
- Blood component recalls in the United States.
- Transfusion. 1999 May;39(5):473-8. Unique Identifier : AIDSLINE MED/99267027
- Ramsey G; Sherman LA; Department of Pathology, Northwestern University Medical School,; Northwestern Memorial University Hospital, Chicago, Illinois; 60611, USA. g-ramsey@nwv.edu
- BACKGROUND: United States blood suppliers are required to recall marketed blood components later found to be in violation of Food and Drug Administration ( FDA ) regulations for safety, purity, and potency. Many recalled units have already been transfuse
- Cost-effectiveness of transfusing virus-inactivated plasma instead of standard plasma.
- Transfusion. 1999 May;39(5):479-87. Unique Identifier : AIDSLINE MED/99267028
- Pereira A; Service of Hemotherapy and Hemostasis and the Blood Bank,; Hospital Clinico, Barcelona, Spain. apereira@medicina.ub.es
- BACKGROUND: Virus inactivation of plasma intended for transfusion avoids the transmission of hepatitis B virus, hepatitis C virus, and HIV. However, because most plasma recipients also receive other blood components concomitantly, the procedure reduces but cannot eliminate the risk of transfusion-transmitted infection
- T-cell development and susceptibility to cyclosporine A-induced autoimmunity in MHC-matched bone marrow/thymus chimeras.
- Transplant Proc. 1999 May;31(3):1579-80. Unique Identifier : AIDSLINE MED/99261394
- Damoiseaux J; van de Gaar J; van der Heijden H; van Breda Vriesman P; Department of Internal Medicine, Maastricht University, The; Netherlands.
- Polarization toward the T-helper(Th)1 type immune response is not required for rat experimental autoimmune myasthenia gravis.
- Transplant Proc. 1999 May;31(3):1604-5. Unique Identifier : AIDSLINE MED/99261404
- Saoudi A; Bernard I; Hoedemaekers A; Cautain B; Martinez K; Druet P; De Baets M; Guery JC; Institut National de la Sante et de la Recherche Medicale; (INSERM U28), Toulouse, France.
- Pediatric oncology and AIDS: therapeutic lessons of relevance to generic drug use.
- Transplant Proc. 1999 May;31(3A Suppl):13S-15S. Unique Identifier : AIDSLINE MED/99261337
- Rodman J; Pharmaceutical Department, St Jude Children's Research Hospital,; Memphis, TN 38105-2794, USA. john.rodman@stjude.org
- Short- and long-term effects of polyclonal antibodies.
- Transplant Proc. 1999 May;31(3B Suppl):12S-15S. Unique Identifier : AIDSLINE MED/99261346
- Muller TF; Grebe SO; Reckzeh B; Borutta A; Radsak K; Lange H; Department of Nephrology, Philipps-University, Marburg, Germany.
- Human immunodeficiency virus type 1 genetic evolution in patients with prolonged suppression of plasma viremia.
- Virology. 1999 Apr 10;256(2):180-7. Unique Identifier : AIDSLINE MED/99208812
- Martinez MA; Cabana M; Ibanez A; Clotet B; Arno A; Ruiz L; Laboratori de Retrovirologia, Hospital Universitari Germans Trias; i Pujol, Badalona, 08916, Spain. mamartz@ns.hugtip.scs.es
- Treatment of human immunodeficiency virus type 1 (HIV-1)-infected patients with combination drug regimens results in a reduction of plasma viral load to levels below the limit of detection. To investigate the genomic fluctuations in HIV-1 populations from long-term responders to antiviral therapies we analyzed the vir
- Role of the myxoma virus soluble CC-chemokine inhibitor glycoprotein, M-T1, during myxoma virus pathogenesis.
- Virology. 1999 Apr 10;256(2):233-45. Unique Identifier : AIDSLINE MED/99208819
- Lalani AS; Masters J; Graham K; Liu L; Lucas A; McFadden G; Departments of Biochemistry, University of Alberta, Edmonton,; Canada.
- Myxoma virus is a poxvirus that causes a virulent systemic disease called myxomatosis in European rabbits. Like many poxviruses, myxoma virus encodes a variety of secreted proteins that subvert the antiviral activities of host cytokines. It was recently demonstrated that the myxoma virus M-T1 glycoprotein is a member
- Identification of the canarypox virus thymidine kinase gene and insertion of foreign genes.
- Virology. 1999 Apr 10;256(2):280-90. Unique Identifier : AIDSLINE GENBANK/D86731
- Amano H; Morikawa S; Shimizu H; Shoji I; Kurosawa D; Matsuura Y; Miyamura T; Ueda Y; Virology II, VIrology I, National Institute of Infectious; Diseases, Gakuen 4-7-1, Musashimurayama, Tokyo, 208, Japan.
- We mapped the canarypox virus (CaPV) thymidine kinase (TK) gene within a 5.8-kbp XbaI fragment of the genome by Southern blotting using the fowlpox virus (FPV) TK gene as a probe. Nucleotide sequence analysis of the fragment revealed seven open reading frames (ORFs) showing gene organization similar to that of FPV. Th
- Long-lasting protection by live attenuated simian immunodeficiency virus in cynomolgus monkeys: no detection of reactivation after stimulation with a recall antigen.
- Unique Identifier : AIDSLINE MED/99208824
- Sernicola L; Corrias F; Koanga-Mogtomo ML; Baroncelli S; Di Fabio S; Maggiorella MT; Belli R; Michelini Z; Macchia I; Cesolini A; Cioe L; Verani P; Titti F; Laboratory of Virology, Istituto Superiore Sanita, Viale Regina; Elena, Rome, 299-00161, Italy.
- The infection of cynomolgus monkeys with an attenuated simian immunodeficiency virus (SIV) (C8) carrying a deletion in the nef gene results in a persistent infection associated with an extremely low viral burden in peripheral blood mononuclear cells. The aim of this study was to determine (1) the breadth of the protec
- Gene regulation mediated by interaction between HTLV-1 promoter elements and transcription factors Tax and CREB.
- Virology. 1999 Apr 10;256(2):303-12. Unique Identifier : AIDSLINE MED/99208825
- Goren I; Tavor E; Honigman A; Department of Virology, The Hebrew University-Hadassah Medical; School, Jerusalem, Israel.
- In this work we examine the role of three genetic control components in the regulation of HTLV-1 transcription: cyclic AMP-responsive element (CRE)-binding protein (CREB), the HTLV-1 trans-activator Tax, and the three Tax-responsive elements (TREs). We demonstrate that the in vivo efficiency of the HTLV-1 promoter bas
- Analysis of human lymphotropic T-cell virus type II-like particle production by recombinant baculovirus-infected insect cells.
- Virology. 1999 Apr 10;256(2):371-80. Unique Identifier : AIDSLINE MED/99208832
- Takahashi RH; Nagashima K; Kurata T; Takahashi H; Department of Pathology, National Institute of Infectious; Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo, 162, Japan.; htakahas@nih.go.jp
- The molecular processes involved in retrovirus assembly and budding formation remain poorly understood. The gag-pro-pol genes of human lymphotropic T-cell virus type II (HTLV-II) are translated into Gag, Gag-Pro, or Gag-Pro-Pol by frameshift events. In the present study, we investigated the roles of the gag, pro, and
- Comparison of human sera reactivities in immunoblots with recombinant human herpesvirus (HHV)-8 proteins associated with the latent (ORF73) and lytic (ORFs 65, K8.1A, and K8.1B) replicative cycles and in immunofluorescence assays with HHV-8-infected BCBL-1 cells.
- Virology. 1999 Apr 10;256(2):381-92. Unique Identifier : AIDSLINE MED/99208833
- Zhu L; Wang R; Sweat A; Goldstein E; Horvat R; Chandran B; Division of Infectious Diseases, The University of Kansas Medical; Center, Kansas City, Kansas, 66160, USA.
- The development of reliable, sensitive, and specific serological methods for the detection of human herpesvirus-8 (HHV-8) antibodies is critical for a thorough understanding of HHV-8 prevalence and pathogenesis. To evaluate the potential usefulness of HHV-8 proteins in measuring the responses against both latent and l
- [Use of muramyl peptides in viral vaccines]
- Vopr Virusol. 1999 Jan-Feb;44(1):4-8. Unique Identifier : AIDSLINE MED/99206230
- Krivorutchenko IuL
- Discusses the selective activation of HIV replication under the effect of various muramylpeptides with immunostimulating effect. Emphasizes the significance of selecting adjuvants inducing no HIV activation, particularly in cases when the vaccines are intended for seropositive subjects.
- Efficacy of Vi polysaccharide vaccine against Salmonella typhi [letter]
- Vaccine. 1999 Mar 5;17(9-10):1015-6. Unique Identifier : AIDSLINE MED/99209984
- Arya SC
- Humoral and cellular immunity induced by antigens adjuvanted with colloidal iron hydroxide.
- Unique Identifier : AIDSLINE MED/99209985
- Leibl H; Tomasits R; Bruhl P; Kerschbaum A; Eibl MM; Mannhalter JW; Department of Immunological Research, Immuno AG, Vienna, Austria.
- The immunopotentiating activities of colloidal iron hydroxide, a novel, experimental mineral adjuvant, and of aluminium hydroxide. the licensed adjuvant for human vaccines, were compared. Our studies revealed that colloidal iron hydroxide and aluminium hydroxide behaved comparably with respect to supporting induction
- Mucosal and systemic immune responses induced after oral delivery of vaccinia virus recombinants.
- Vaccine. 1999 Mar 5;17(9-10):1074-83. Unique Identifier : AIDSLINE MED/99209992
- Gherardi MM; Esteban M; Department of Molecular and Cellular Biology, Centro Nacional de; Biotecnologia, CSIC, Campus Universidad Autonoma, Madrid,; Spain.
- The immune responses elicited after oral delivery of vaccinia virus (VV) recombinants are not well defined. In this study we show with mice, that after oral administration of a VV recombinant expressing the luciferase reporter gene, VV gene expression takes place for several days in gut-associated lymphoid (GALT) tiss
- The business of science and the science of business in the quest for an AIDS vaccine.
- Vaccine. 1999 Mar 5;17(9-10):1211-22. Unique Identifier : AIDSLINE MED/99210010
- Hilleman MR; Merck Research Laboratories, Merck Institute for Therapeutic; Research, West Point, PA 19486, USA.
- This paper simplifies and encapsulates the past, present and future for developing vaccines, especially against AIDS. Needed technical information and how it can best be obtained are delineated. The views are my own and may not be shared by others. The science enterprise, including that for vaccines, is enmeshed in th
- A novel influenza subunit vaccine composed of liposome-encapsulated haemagglutinin/neuraminidase and IL-2 or GM-CSF. II. Induction of TH1 and TH2 responses in mice.
- Vaccine. 1999 Mar 5;17(9-10):1239-50. Unique Identifier : AIDSLINE MED/99210012
- Babai I; Samira S; Barenholz Y; Zakay-Rones Z; Kedar E; The Lautenberg Center for General and Tumor Immunology, The; Hebrew University-Hadassah Medical School, Jerusalem, Israel.
- This study was aimed at analyzing, in parallel, the humoral and cellular immune responses elicited in mice immunized with liposomal influenza A (Shangdong/9/93) subunit vaccines composed of haemagglutinin/neuraminidase (H3N2) and IL-2 or GM-CSF. Recently, we reported t
- The major Epstein-Barr virus (EBV) envelope glycoprotein gp340 when incorporated into Iscoms primes cytotoxic T-cell responses directed against EBV lymphoblastoid cell lines.
- Vaccine. 1999 Mar 5;17(9-10):1282-90. Unique Identifier : AIDSLINE MED/99210016
- Wilson AD; Lovgren-Bengtsson K; Villacres-Ericsson M; Morein B; Morgan AJ; Department of Pathology and Microbiology, School of Medical; Sciences, University of Bristol, UK.
- A recombinant form of the EBV envelope glycoprotein and vaccine candidate gp340, lacking its hydrophobic transmembrane region, was incorporated into Iscoms after coupling to phosphatidyl ethanolamine via carbohydrate residues. Coupling by partial oxidation of gp340 carbohydrate with sodium periodate partly denatured t
- HPV testing in the evaluation of the minimally abnormal Papanicolaou smear.
- Am Fam Physician. 1999 May 15;59(10):2794-801. Unique Identifier : AIDSLINE MED/99275827
- Apgar BS; Brotzman G; Department of Family Medicine, University of Michigan Medical; School, Ann Arbor, USA.
- Minor cytologic abnormalities of the cervix, such as atypical squamous cells of undetermined significance (ASCUS), are vastly more common than high-grade squamous intraepithelial lesions or invasive cancer. Current guidelines for the management of ASCUS include repeating the Papanicolaou (Pap) smear at specific interv
- HIV patients receiving HAART therapy can still transmit the virus. Highly active antiretroviral chemotherapy.
- Am Fam Physician. 1999 May 15;59(10):2855. Unique Identifier : AIDSLINE MED/99275833
- Pomerantz RJ; Thomas Jefferson University, Philadelphia, USA.
- Chronic pure red cell aplasia caused by parvovirus B19 in AIDS: use of intravenous immunoglobulin--a report of eight patients.
- Am J Hematol. 1999 May;61(1):16-20. Unique Identifier : AIDSLINE MED/99260349
- Koduri PR; Kumapley R; Valladares J; Teter C; Department of Medicine, Cook County Hospital, Chicago, Illinois,; USA.
- The optimal management of chronic pure red cell aplasia caused by parvovirus B19 (B19-PRCA) in patients with AIDS is unclear. Our purpose was to determine the effects of intravenous immunoglobulin (IVIg) in the treatment of B19-PRCA in patients with AIDS. The patients were eight adults with AIDS admitted during the pe
- High prevalence of HTLV-I infection among the family members of a patient with adult T-cell leukemia/lymphoma from northeastern Japan.
- Am J Hematol. 1999 May;61(1):78-81. Unique Identifier : AIDSLINE MED/99260358
- Shimizu K; Department of Medicine, Nagoya City Higashi General Hospital,; Nagoya, Japan.
- Human T-cell lymphotropic virus type I (HTLV-I) is transmitted through infected lymphocytes mostly by breast feeding. In the present study, high prevalence of HTLV-I infection was disclosed in the family members of a patient with adult T-cell leukemia/lymphoma (ATL), all of whom were residents of Iwate, northeastern
- Withdrawal of Pneumocystis carinii pneumonia prophylaxis after combination antiretroviral therapy in patients with AIDS [letter]
- Am J Med. 1999 May;106(5):598-9. Unique Identifier : AIDSLINE MED/99266767
- Garcia Vazquez E; de Gorgolos M; Fernandez Guerrero ML
- Pediatric AIDS-associated lymphocytic interstitial pneumonia and pulmonary arterio-occlusive disease: role of VCAM-1/VLA-4 adhesion pathway and human herpesviruses.
- Am J Pathol. 1999 May;154(5):1453-64. Unique Identifier : AIDSLINE MED/99263382
- Brodie SJ; de la Rosa C; Howe JG; Crouch J; Travis WD; Diem K; Department of Laboratory Medicine, Vaccine/Virology Division,; Retrovirology Laboratory, Seattle, WA 98195, USA.; sjbrodie@u.washington.edu
- Because the mechanisms of lymphocyte accumulation in the lungs of children with AIDS-associated lymphocytic interstitial pneumonia (LIP) are unknown, we studied the relative contributions of known adhesion pathways in mediating lymphocyte adherence to endothelium and the potential role of human herpesviruses in the ex
- Analysis of the three enzymatic activities of HIV-1 integrase in vitro using minigels for detection of the reaction products.
- Anal Biochem. 1999 Apr 10;269(1):189-92. Unique Identifier : AIDSLINE MED/99196691
- Sayasith K; Sauve G; Yelle J; Centre de recherche en virologie, Institut Armand-Frappier,; Edifice 22, 531 boul. des Prairies, Laval, Quebec, H7N 4Z3,; Canada.
- Use of a phosphotyrosine-antibody pair as a general detection method in homogeneous time-resolved fluorescence: application to human immunodeficiency viral protease.
- Anal Biochem. 1999 Apr 10;269(1):79-93. Unique Identifier : AIDSLINE MED/99196677
- Cummings RT; McGovern HM; Zheng S; Park YW; Hermes JD; Department of Molecular Design and Diversity, Merck Research; Laboratories, Rahway, New Jersey 07065-0900, USA.; richard_cummings@merck.com
- A homogeneous time-resolved fluorescence (HTRF) assay has been developed for human immunodeficiency viral (HIV) protease. The assay utilizes a peptide substrate, differentially labeled on either side of the scissile bond, to bring two detection components, streptavidin-cross-linked XL665 (SA/XL665) and a europium cryp
- [Diagnostic case. Anaplastic cutaneous lymphoma]
- Ann Dermatol Venereol. 1999 Jan;126(1):63-5. Unique Identifier : AIDSLINE MED/99195634
- Toutous-Trellu L; Girardet C; Meynard A; Pechere M; Clinique et policlinique de dermatologie, Hopital Cantonal; Universitaire de Geneve, Suisse.
- Bile salts: natural detergents for the prevention of sexually transmitted diseases.
- Antimicrob Agents Chemother. 1999 Apr;43(4):745-51. Unique Identifier : AIDSLINE MED/99216880
- Herold BC; Kirkpatrick R; Marcellino D; Travelstead A; Pilipenko V; Krasa H; Bremer J; Dong LJ; Cooper MD; Department of Pediatrics, Mount Sinai School of Medicine, New; York, New York 10029, USA. betsy_herold@smtplink.mssm.edu
- The development of new, safe, topical microbicides for intravaginal use for the prevention of sexually transmitted diseases is imperative. Previous studies have suggested that bile salts may inhibit human immunodeficiency virus infection; however, their activities against other sexually transmitted pathogens have not
- Effects of azole antifungal drugs on the transition from yeast cells to hyphae in susceptible and resistant isolates of the pathogenic yeast Candida albicans.
- Antimicrob Agents Chemother. 1999 Apr;43(4):763-8. Unique Identifier : AIDSLINE MED/99216883
- Ha KC; White TC; Department of Pathobiology, School of Public Health and Community; Medicine, University of Washington, Seattle, USA.
- Oral infections caused by the yeast Candida albicans are some of the most frequent and earliest opportunistic infections in human immunodeficiency virus-infected patients. The widespread use of azole antifungal drugs has led to the development of drug resistance, creating a major problem in the treatment of yeast infe
- 9-[2-(Phosphonomethoxy)propyl]adenine (PMPA) therapy prolongs survival of infant macaques inoculated with simian immunodeficiency virus with reduced susceptibility to PMPA.
- Antimicrob Agents Chemother. 1999 Apr;43(4):802-12. Unique Identifier : AIDSLINE MED/99216889
- Van Rompay KK; Cherrington JM; Marthas ML; Lamy PD; Dailey PJ; Canfield DR; Tarara RP; Bischofberger N; Pedersen NC; California Regional Primate Research Center, University of; California, Davis 95616, USA. kkvanrompay@ucdavis.edu
- Simian immunodeficiency virus (SIV) infection of newborn rhesus macaques is a useful animal model of human immunodeficiency virus infection for the study of the emergence and clinical implications of drug-resistant viral mutants. We previously demonstrated that SIV-infected infant macaques receiving prolonged treatmen
- Pharmacokinetics of beta-L-2',3'-dideoxy-5-fluorocytidine in rhesus monkeys.
- Antimicrob Agents Chemother. 1999 Apr;43(4):920-4. Unique Identifier : AIDSLINE MED/99216905
- Martin LT; Cretton-Scott E; Schinazi RF; Zhou XJ; McClure HM; Mathe C; Gosselin G; Imbach JL; Sommadossi JP; Department of Clinical Pharmacology, University of Alabama,; Birmingham 35294, USA.
- beta-L-2 ,3 -Dideoxy-5-fluorocytidine (beta-L-FddC), a novel cytidine analog with an unnatural beta-L sugar configuration, has been demonstrated by our group and others to exhibit highly selective in vitro activity against human immunodeficiency virus types 1 and 2 and hepatitis B virus. This encouraging in vitro anti
- Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheres in rabbits.
- Antimicrob Agents Chemother. 1999 Apr;43(4):972-4. Unique Identifier : AIDSLINE MED/99216919
- Callender DP; Jayaprakash N; Bell A; Petraitis V; Petratienes R; Candelario M; Schaufele R; Dunn JM; Sei S; Walsh TJ; Balis FM; Pediatric Oncology Branch, National Cancer Institute, Bethesda,; Maryland 20892, USA.
- The pharmacokinetic profile of oral zidovudine entrapped in a 50:50 polyactide-coglycolide matrix (nanospheres) was compared to those of standard oral and parenteral zidovudine formulations in rabbits. The bioavailability of zidovudine nanospheres at 50 mg/kg of body weight was 76%, and this dose achieved prolonged ex
- Effect of 3-hydroxyphthaloyl-beta-lactoglobulin on vaginal transmission of simian immunodeficiency virus in rhesus monkeys.
- Antimicrob Agents Chemother. 1999 Apr;43(4):978-80. Unique Identifier : AIDSLINE MED/99216921
- Wyand MS; Manson KH; Miller CJ; Neurath AR; Primedica Corporation, Worcester, Massachusetts 01608, USA.; michael.wyand@primedica.com
- Heterosexual transmission of human immunodeficiency virus type 1 (HIV-1) is the major cause of the ongoing AIDS epidemic. Application of chemical barrier methods is expected to contribute to the worldwide control of this epidemic. Bovine beta-lactoglobulin modified by 3-hydroxyphthalic anhydride (3-hydroxyphthalovyl-b
- Lack of ritonavir antifungal effect in vitro [letter]
- Antimicrob Agents Chemother. 1999 Apr;43(4):997. Unique Identifier : AIDSLINE MED/99216929
- Diz P; Ocampo A; Iglesias I; Otero I
- Clinical progress and the future of HIV exceptionalism.
- Arch Intern Med. 1999 May 24;159(10):1042-8. Unique Identifier : AIDSLINE MED/99266711
- Bayer R; Division of Sociomedical Sciences, Columbia University School of; Public Health, New York, NY 10032, USA. rb8@columbia.edu
- In the 18 years since the first cases of the acquired immunodeficiency syndrome (AIDS) were reported by the Centers for Disease Control and Prevention (CDC), the epidemic has undergone profound transformations, and so, too, has the sociomedical context within which public health policy is fashioned and implemented. Th
- Predictors of sputum culture conversion among patients with tuberculosis in the era of tuberculosis resurgence.
- Arch Intern Med. 1999 May 24;159(10):1110-6. Unique Identifier : AIDSLINE MED/99266720
- Liu Z; Shilkret KL; Ellis HM; New Jersey Department of Health and Senior Services, Division of; Communicable Diseases, Trenton 08625-0369, USA. liu1106W@cdc.gov
- BACKGROUND: Sputum culture conversion among patients with tuberculosis (TB) is the most important indicator for the effectiveness of treatment and the infectivity of the disease. We sought to investigate predictors for documented sputum culture conversion among TB cases reported in the surveillance system. METHODS: Th
- Carnitine stands on its own in HIV infection treatment [letter]
- Arch Intern Med. 1999 May 24;159(10):1143-4. Unique Identifier : AIDSLINE MED/99266728
- Famularo G; De Simone C
- Progressive multifocal leukoencephalopathy and JC virus genotypes in West African patients with acquired immunodeficiency syndrome: a pathologic and DNA sequence analysis of 4 cases.
- Arch Pathol Lab Med. 1999 May;123(5):395-403. Unique Identifier : AIDSLINE MED/99249576
- Chima SC; Agostini HT; Ryschkewitsch CF; Lucas SB; Stoner GL; Neurotoxicology Section, National Institute of Neurological; Disorders and Stroke, National Institutes of Health, Bethesda, MD; 20892-4126, USA.
- OBJECTIVE: Progressive multifocal leukoencephalopathy is caused by polyomavirus JC in immunosuppressed patients. JC virus genotypes are identified by sequence analysis of the viral genome. Despite the prevalence of acquired immunodeficiency syndrome in sub-Saharan Africa, few cases of progressive multifocal leukoencep
- Musculoskeletal rehabilitation and sports medicine. 4. Miscellaneous sports medicine topics.
- Arch Phys Med Rehabil. 1999 May;80(5 Suppl 1):S68-89. Unique Identifier : AIDSLINE MED/99256837
- Smith J; Wilder RP; Mayo Clinic, Rochester, MN 55905, USA.
- This self-directed learning module highlights new advances in this topic area. It is part of the chapter on musculoskeletal rehabilitation and sports medicine in the Self-Directed Physiatric Education Program for practitioners and trainees in physical medicine and rehabilitation. This article discusses physiatric duti
- Effect of nucleoside analogs and non-nucleoside inhibitors of HIV-1 reverse transcriptase on cell-free virions.
- Arch Virol. 1999;144(3):513-23. Unique Identifier : AIDSLINE MED/99243204
- Ventura M; Tarrago-Litvak L; Dolle V; Nguyen CH; Legraverend M; Fleury HJ; Litvak S; EP 630 CNRS-Universite Victor Segalen, Bordeaux, France.
- Reverse transcription takes place in the cytoplasm of infected cells, although it has been demonstrated that retroviruses can also initiate reverse transcription prior to infection of target cells. In addition to partial reverse transcripts, full-length proviral molecules have been detected in the plasma and seminal f
- The use of gloves in Australian dermatological practice.
- Australas J Dermatol. 1999 May;40(2):83-8. Unique Identifier : AIDSLINE MED/99266160
- Ong CS; Commens CA; Department of Dermatology, Westmead Hospital, New South Wales,; Australia. search4@ozemail.com.au
- Dermatologists use gloves as a major tool in universal precautions to prevent transmission of infections particularly human immunodeficiency virus (HIV) and hepatitis. We need to know how much protection is conferred by gloves and what problems are associated with glove use. This paper looks at these issues and report
- A program of acquired immune deficiency syndrome education for nurses in Romania.
- J Pediatr Oncol Nurs. 1999 Apr;16(2):68-73. Unique Identifier : AIDSLINE MED/99261711
- Simon C; Evans K; Calles NR; Harris AT; Dobmeier M; Moreau L; Owen C; Rayburn T; Baylor College of Medicine, Houston, TX, USA.
- After the fall of the communist government in Romania , many children were found to be human immunodeficiency virus (HIV) infected. The majority of these children were abandoned and currently live in orphanages. The children have been cared for on a day-to-day basis by nurses with
- Perforin-independent CD8(+) T-cell-mediated cytotoxicity of alveolar epithelial cells is preferentially mediated by tumor necrosis factor-alpha: relative insensitivity to Fas ligand.
- Am J Respir Cell Mol Biol. 1999 May;20(5):849-58. Unique Identifier : AIDSLINE MED/99244590
- Liu AN; Mohammed AZ; Rice WR; Fiedeldey DT; Liebermann JS; Whitsett JA; Braciale TJ; Enelow RI; Beirne B. Carter Center for Immunology Research, Department of; Medicine, University of Virginia School of Medicine,; Charlottesville, Virginia, USA.
- CD8(+) T cells appear to play an important pathophysiologic role in many inflammatory lung diseases. The primary effector function of this T-cell subset is cytolysis of virus-infected cells, and it is widely believed that there are two primary molecular mechanisms by which this occurs: the perforin/granzyme-mediated p
- Promiscuous chemokine receptors and their redundant ligands play an enigmatic role during HIV-1 infection.
- Am J Respir Cell Mol Biol. 1999 May;20(5):859-60. Unique Identifier : AIDSLINE MED/99244591
- Kunkel SL; Department of Pathology, University of Michigan Medical School,; Ann Arbor, Michigan, USA.
- CD4 receptor-dependent entry of human immunodeficiency virus type-1 env-pseudotypes into CCR5-, CCR3-, and CXCR4-expressing human alveolar macrophages is preferentially mediated by the CCR5 coreceptor.
- Am J Respir Cell Mol Biol. 1999 May;20(5):864-71. Unique Identifier : AIDSLINE MED/99244593
- Park IW; Koziel H; Hatch W; Li X; Du B; Groopman JE; Divisions of Experimental Medicine, Hematology/Oncology, and; Pulmonary and Critical Care Medicine, Department of Medicine,; Beth Israel Deaconess Medical Center and Harvard Medical School,; Boston, Massachusetts, USA.
- Alveolar macrophages (AM) are important host-defense cells and targets of human immunodeficiency virus type 1 (HIV-1) infection. However, the receptors mediating HIV-1 entry into AM are not completely characterized. We observed that, in addition to CD4 receptors, AM from healthy adults expressed low levels of CCR5, CC
- [Meningitis in subjects with human immunodeficiency virus infection]
- Neurologia. 1999 Feb;14(2):62-6. Unique Identifier : AIDSLINE MED/99200194
- Silva-Rosas C; Afani A; Fruns M; Guzman MA; Sepulveda C; Departamento de Neurologia-Neurocirugia, Hospital Clinico de; la Universidad de Chile, Santiago de Chile.
- BACKGROUND: Neurological complications are frequently observed in HIV-1 patients. Lumbar puncture (LP) and LSF analysis are two key diagnostic procedures. AIM: To describe the etiology meningeal syndromes in a hospital series of HIV patients. RESULTS: In this study, we present the different meningeal complications fro
- Pharmacokinetic variability and strategy for therapeutic drug monitoring of saquinavir (SQV) in HIV-1 infected individuals.
- Br J Clin Pharmacol. 1999 Apr;47(4):379-82. Unique Identifier : AIDSLINE MED/99249929
- Regazzi MB; Villani P; Maserati R; Cocchi L; Giacchino R; Burroni D; Rettani M; Department of Infectious Diseases, IRCCS Policlinico San Matteo,; University of Pavia, Pavia, Italy.
- AIMS: To investigate the pharmacokinetic profile of the protease inhibitor saquinavir (SQV) after multiple doses in HIV-positive patients and to evaluate the possibility of predicting total body exposure of SQV from concentrations determined at single time points. METHODS: Twenty HIV-positive patients on steady-state
- Strongyloides hyperinfection in adult T-cell leukaemia/lymphoma.
- Br J Haematol. 1999 Apr;105(1):1. Unique Identifier : AIDSLINE MED/99291718
- Pagliuca A; Guy's King's and St Thomas's School of Medicine, King's College,; London.
- Paraproteins and monoclonal expansion of CD3+CD8+ CD56-CD57+ T lymphocytes in a patient with HIV infection.
- Br J Haematol. 1999 Apr;105(1):85-7. Unique Identifier : AIDSLINE MED/99250507
- Smith P; Helbert M; Raftery M; Forster G; Cavenagh J; Department of Genitourinary Medicine, Royal Hositals NHS Trust,; Whitechapel, London.
- An expansion of CD8+ lymphocytes associated with a monoclonal rearrangement of the T-cell receptor gamma locus was found in a woman with HIV-1 infection. A subpopulation of HIV-positive patients display an unusual response to HIV infection characterized by a persistent marked CD8+ lymphocytosis, the presence of which
- Site-specific deuterium order parameters and membrane-bound behavior of a peptide fragment from the intracellular domain of HIV-1 gp41.
- Biochemistry. 1999 May 11;38(19):6327-34. Unique Identifier : AIDSLINE MED/99255391
- Koenig BW; Ferretti JA; Gawrisch K; Laboratory of Membrane Biochemistry and Biophysics, NIAAA,; National Institutes of Health, 12420 Parklawn Drive, Room 158,; Rockville, Maryland 20852, USA.
- The behavior of the cytolytic peptide fragment 828-848 (P828) from the carboxy-terminus of the envelope glycoprotein gp41 of HIV-1 in membranes was investigated by solid-state 2H NMR on P828 with the selectively deuterated isoleucines I3, I13, I16, and I20. The quadrupole splittings of the I3 side chain show significa
- [Left-sided endocarditis in patients with HIV infection]
- An Med Interna. 1999 Apr;16(4):171-4. Unique Identifier : AIDSLINE MED/99271198
- Valencia Ortega ME; Guinea Esquerdo J; Enriquez Crego A; Moreno Celda V; Laguna Cuesta F; Gonzalez Lahoz J; Servicio de Enfermedades Infecciosas, Hospital Carlos III,; Madrid.
- BACKGROUND: Left-sided endocarditis in HIV-infected patients has an special clinical, epidemiological and microbiological characteristics and its relationship with drug addicts subjects is unknown. PATIENTS AND METHODS: Since 1986 up to 1996 we have been diagnosed 214 episodes of infective endocarditis in 190 HIV-infe
- [Non-Hodgkin's disease of the skull in a patient with AIDS]
- An Med Interna. 1999 Apr;16(4):186-8. Unique Identifier : AIDSLINE MED/99271202
- Jimenez Moragas JM; Sanchez Rodriguez A; Sierra Camerino R; Palomo Gonzalez MJ; Servicio de Cuidados Criticos y Urgencias, Hospital; Universitario Puerta del Mar, Cadiz.
- The involvement of bone in non-Hodgkin s lymphoma (NHL) is rare and usually occurs in the late stages of the disease. The involvement of the cranial vault is exceptional and we have found only eleven cases previously reported in the revised literature, none of them in an AIDS patie
- [Pneumonitis associated with primary infection by varicella-zoster virus: apropos of 11 cases (letter)]
- An Med Interna. 1999 Apr;16(4):209-10. Unique Identifier : AIDSLINE MED/99271213
- Barreiro Garcia PM; Pintor Holguin E; Buron Fernandez MR; Diaz Pollan B; Roca Arbones V
- [Thrombotic thrombocytopenic purpura associated with HIV infection (letter)]
- An Med Interna. 1999 Apr;16(4):210-1. Unique Identifier : AIDSLINE MED/99271214
- Bayo Poleo R; Antona Diaz M; Lopez Rodriguez A; Lopez Sanchez L
- HHV-8 is present in multiple myeloma patients.
- Blood. 1999 May 15;93(10):3157-9; discussion 3164-6. Unique Identifier : AIDSLINE MED/99252069
- Berenson JR; Vescio RA; Veterans Affairs West Los Angeles Medical Center, Jonsson; Comprehensive Cancer Center and Division of Hematology and; Oncology, University of California School of Medicine, Los; Angeles, CA, USA. BERENSON.JAMES@WEST-LA.VA.GOV
- Kaposi's sarcoma-associated herpesvirus and multiple myeloma: lack of criteria for causality.
- Blood. 1999 May 15;93(10):3159-63; discussion 3163-4. Unique Identifier : AIDSLINE MED/99252070
- Tarte K; Chang Y; Klein B; INSERM U475, Montpellier, France; the Department of Pathology,; College of Physicians and Surgeons, Columbia University, New; York, NY, USA.
- Human thymocytes express CCR-3 and are activated by eotaxin.
- Blood. 1999 May 15;93(10):3233-40. Unique Identifier : AIDSLINE MED/99252076
- Franz-Bacon K; Dairaghi DJ; Boehme SA; Sullivan SK; Schall TJ; Conlon PJ; Taylor N; Bacon KB; Departments of Immunology and Molecular Biology, DNAX Research; Institute, Palo Alto, CA, USA.
- Eotaxin has been characterized as a chemokine involved in eosinophil activation; however, mRNA for this C-C chemokine has been shown to be constitutively expressed in thymus. Immunohistochemical analysis showed a punctate distribution pattern, with eotaxin expression localized mainly in the medulla and in Hassle s cor
- An essential role for NF-kappaB in human CD34(+) bone marrow cell survival.
- Blood. 1999 May 15;93(10):3302-8. Unique Identifier : AIDSLINE MED/99252084
- Pyatt DW; Stillman WS; Yang Y; Gross S; Zheng JH; Irons RD; The Molecular Toxicology and Environmental Health Sciences; Center, School of Pharmacy, University of Colorado Health; Sciences Center, Denver, CO, USA.
- The transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting against apoptosis in a variety of cell types. However, a role for NF-kappaB in human CD34(+) bone marrow cells has not be
- [Effect of yifei kangliu yin on lung cancer metastasis and immune function]
- Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1997 Jul;17(7):401-3. Unique Identifier : AIDSLINE MED/99256168
- Xu L; Liu JX; Changzheng Hospital, Shanghai.
- OBJECTIVE: To explore the effect of Yifei Kangliu Yin (YFKLY) on metastasis of lung cancer and immune function. METHODS: (1) Observing remote metastasis of three groups (n = 94) lung cancer patients, measuring the activity of NK cell, and the levels of OKT3, OKT4 of the patients by radioimmunoassay, and doing compared
- Modulation of an allergic immune response via the mucosal route in a murine model of inhalative type-I allergy.
- Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):129-32. Unique Identifier : AIDSLINE MED/99242414
- Wiedermann U; Jahn-Schmid B; Repa A; Kraft D; Ebner C; Institute of General and Experimental Pathology, Division; Immunopathology, University of Vienna, Austria.; ursula.wiedermann@akh-wien.ac.at
- A murine model of aerosol inhalation, leading to sensitization to birch pollen (BP) and its major allergen Bet v 1, was established in order to try to influence type-I allergic immune responses via the mucosal route. We previously demonstrated that simultaneous inhalation of BP and cholera toxin, a potent mucosal adju
- T cells and chronic asthma.
- Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):133-5. Unique Identifier : AIDSLINE MED/99242415
- Kon OM; Kay AB; Allergy and Clinical Immunology, National Heart and Lung; Institute, Imperial College School of Medicine, London, UK.
- There is increasing evidence that the asthma process is driven and maintained by persistence of a subset of chronically activated T memory cells, sensitized against allergenic, occupational or viral antigens which home to the lung after antigen exposure or viral infection. In general, allergens induce a CD4 T help
- Cloned Th cells confer eosinophilic inflammation and bronchial hyperresponsiveness.
- Unique Identifier : AIDSLINE MED/99242416
- Kaminuma O; Mori A; Ogawa K; Nakata A; Kikkawa H; Ikezawa K; Okudaira H; Department of Medicine and Physical Therapy, Faculty of Medicine,; University of Tokyo, Japan. osamu@liai.org
- BACKGROUND: The essential role of Th cells and T cell cytokines in eosinophilic inflammation has been established. METHODS: To determine whether Th cells are sufficient for the development of airway eosinophilic inflammation, ovalbumin-reactive murine Th clones were established and infused into unprimed mice. RESULTS:
- Do Tr1 cells play a role in immunotherapy?
- Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):210-1. Unique Identifier : AIDSLINE MED/99242437
- Saloga J; Bellinghausen I; Knop J; Department of Dermatology, University of Mainz, Germany.; Saloga@hautklinik.klinik.uni-mainz.de
- CD8 T-lymphocyte-mediated regulation of ovalbumin-specific murine IgE responses.
- Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):289-91. Unique Identifier : AIDSLINE MED/99242469
- Thomas MJ; MacAry PA; Kemeny DM; Department of Immunology, Rayne Institute, Kings College School; of Medicine and Dentistry, London, UK.
- IL-10 induces a Th2 cell tolerance in allergic asthma.
- Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):391-4. Unique Identifier : AIDSLINE MED/99242511
- Adachi M; Oda N; Kokubu F; Minoguchi K; First Department of Internal Medicine, Showa University, Tokyo,; Japan.
- BACKGROUND: Interleukin (IL)-10 induces a long-term antigen-specific anergy in human CD4+ T cells. METHODS: Peripheral blood mononuclear cells (PBMCs) were isolated from house dust mite (Dermatophagoides farinae, Der f)-sensitized asthmatic patients. PBMCs were stimulated with Der f antigen for 72 h immediately after
- Do allergens induce type-2 immune responses?
- Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):399-402. Unique Identifier : AIDSLINE MED/99242513
- Comoy E; Pestel J; Stewart GA; Finkelman F; Capron A; Thyphronitis G; INSERM U167, Institut Pasteur, Lille, France.
- Implications of the grass group I allergens on the sensitization and provocation process.
- Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):411-3. Unique Identifier : AIDSLINE MED/99242516
- Petersen A; Grobe K; Schramm G; Vieths S; Altmann F; Schlaak M; Becker WM; Forschungszentrum Borstel, Biochemische und Molekulare; Allergologie, Borstel, Germany. apeters@fz-borstel.de
- Grass pollen allergens of group I are particularly important because of their high IgE prevalence and occurrence in all grass species. Four independent IgE-binding regions and one continous epitope were identified. The posttranslational modifications on the molecule increased allergenicity. Phl p 1 is a cysteine prote
- IL-4 inhibits human CD8 T cell expression of the common IL-2 receptor gamma chain.
- Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):433-6. Unique Identifier : AIDSLINE MED/99242522
- Vyas B; Vukmanovic-Stejic M; Noble A; Kemeny DM; Department of Immunology, Guy's, King's, and St. Thomas's School; of Medicine, Rayne Institute, London, UK.
- Previous studies in both rats and humans have shown that interleukin (IL) 4 can suppress the generation of IL-2-producing CD8 T cells. In an attempt to elucidate the mechanism by which this suppression is brought about, we set out to investigate whether the IL-4 signal interferes with the IL-2 receptor system. It has
- DNA-Based immunization for asthma.
- Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):453-6. Unique Identifier : AIDSLINE MED/99242528
- Broide D; Raz E; University of California San Diego, Department of Medicine, La; Jolla, CA, USA. dbroide@ucsd.edu
- BACKGROUND: Immunostimulatory DNA sequences (ISS) containing a CpG motif are able to inhibit Th2-mediated airway eosinophilia and bronchial hyperresponsiveness in a mouse model of asthma. METHODS: To determine the optimal frequency and timing of intervention with ISS in inhibiting Th2 cytokine production and airway eo
- Bacterial DNA and CpG-containing oligodeoxynucleotides activate cutaneous dendritic cells and induce IL-12 production: implications for the augmentation of Th1 responses.
- Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):457-61. Unique Identifier : AIDSLINE MED/99242529
- Jakob T; Walker PS; Krieg AM; von Stebut E; Udey MC; Vogel JC; Dermatology Branch, National Cancer Institute, National; Institutes of Health, Bethesda, MD, USA. thilo.jakob@gsf.de
- BACKGROUND: Unmethylated CpG sequences in bacterial DNA act as adjuvants selectively inducing Th1 predominant immune responses during genetic vaccination or when used in conjunction with protein Ag. The precise mechanism of this adjuvant effect is unknown. Because dendritic cells (DC) are thought to be crucially invol
- Role of the Th2 cytokines in the development of allergen-induced airway inflammation and hyperresponsiveness.
- Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):90-4. Unique Identifier : AIDSLINE MED/99242403
- Hamelmann E; Wahn U; Gelfand EW; Universitats-Kinderklinik Charite, Berlin, Germany.; eckard.hamelmann@charite.de
- Increased production of interleukin (IL)-4 and IL-5 by T-helper cells may be pivotal for the induction and regulation of allergic diseases. We have studied the role of IL-4 and IL-5 in the development of eosinophilic airway inflammation (AI) and airway hyperresponsiveness (AHR) in a mouse model of allergen-induced bro
- Expression of Th1 and Th2 immunoregulatory cytokines by human eosinophils.
- Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):95-7. Unique Identifier : AIDSLINE MED/99242404
- Woerly G; Roger N; Loiseau S; Capron M; INSERM U167, Institut Pasteur, and University of Lille II, Lille,; France.
- Besides cytotoxic mediators, human eosinophils can produce proinflammatory and anti-inflammatory cytokines, as well as growth factors and chemokines. The demonstration that eosinophils from patients could produce IL-5, IL-4 and IL-2 suggested their participation in the
- On the role of T lymphocytes in stimulation of humoral immunity induced by peptidoglycan-monomer linked with zinc.
- Int Arch Allergy Immunol. 1999 May;119(1):13-22. Unique Identifier : AIDSLINE MED/99274714
- Ravlic-Gulan J; Radosevic-Stasic B; Trobonjaca Z; Petkovic M; Cuk M; Rukavina D; Department of Physiology and Immunology, Medical Faculty,; University of Rijeka, Croatia.
- Effects of peptidoglycan linked with zinc (PGM-Zn) were investigated on plaque-forming cell (PFC) generation to sheep red blood cell (SRBC) and SRBC-unrelated antibody production in primary and secondary immune response in mice depleted in vivo of CD4+ and/or CD8+ T lymphocytes. PGM-Zn in nondepleted mice stimulated t
- ABC of labour care: labour in special circumstances.
- BMJ. 1999 Apr 24;318(7191):1124-7. Unique Identifier : AIDSLINE MED/99233896
- Chamberlain G; Steer P
- South African government's response to AIDS crisis is sound.
- BMJ. 1999 Apr 24;318(7191):1143. Unique Identifier : AIDSLINE MED/99233915
- Schuklenk U
- Medical student electives and infectious diseases. Zidovudine alone is not recommended prophylaxis [letter]
- BMJ. 1999 Apr 24;318(7191):1145-6. Unique Identifier : AIDSLINE MED/99233921
- Meadway J
- Medical student electives and infectious diseases. Risk of hepatitis C is greater than HIV [letter]
- BMJ. 1999 Apr 24;318(7191):1146. Unique Identifier : AIDSLINE MED/99285503
- Green ST
- Immune function in hyperbaric environments, diving, and decompression.
- Undersea Hyperb Med. 1999 Spring;26(1):27-39. Unique Identifier : AIDSLINE MED/99281448
- Brenner I; Shephard RJ; Shek PN; Defence & Civil Institute of Environmental Medicine, Toronto,; Canada.
- The purpose of this review is to examine the influence of exposure to hyperbaric oxygen (HBO2) deep diving, and decompression on various facets of the immune response. Potential changes during exposure include a decrease in the CD4+:CD8+ ratio, a decreased proliferation of lymphocytes, and an activation of neutrophils
- Post transplant CD8+ gammadelta T-cell lymphoma associated with human herpes virus-6 infection.
- Leuk Lymphoma. 1999 Apr;33(3-4):377-84. Unique Identifier : AIDSLINE MED/99236708
- Lin WC; Moore JO; Mann KP; Traweek ST; Smith C; Division of Oncology and Transplantation, Department of Medicine,; Duke University Medical Center, Durham, NC 27710, USA.; lin00011@mc.duke.edu
- Gammadelta T-cell lymphoma is a rare T-cell lymphoproliferative disorder that has been reported in both immunocompetent and immunocompromised persons. This report describes a forty eight year old patient who developed gammadelta T-cell lymphoma four years after undergoing living-related kidney transplantation. The lym
- [The patterns in the molecular biology of the adenoviruses (the results of a 20-year study at the Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine)]
- Mikrobiol Z. 1999 Jan-Feb;61(1):3-31. Unique Identifier : AIDSLINE MED/99261131
- Diachenko NS; Institute of Microbiology and Virology, National Academy of; Sciences of Ukraine, Kyiv.
- Scientific data of the highest importance and priority concerning regularities of structural and functional organization of proteins of adenoviruses capsids and peculiarities of expression of the virus genome are as follows: New antigen determinants of hexon and adenovirus fiber have been discovered, their different n
- [Surfactants as agents for the individual prevention of HIV/AIDS]
- Mikrobiol Z. 1999 Jan-Feb;61(1):95-103. Unique Identifier : AIDSLINE MED/99261134
- Krivorutchenko IuL; Crimean Medical Institute, Simferopol, Ukraine.
- Nowadays it is of great importance to develop effective prevention strategies to combat further spread of the AIDS epidemic via sexual transmission of the human immunodeficiency virus. These measures include public information on the disease, widespread condom promotion and prevention of HIV infection by locally appli
- HHV-8/KSHV is not associated with AIDS-related primary central nervous system lymphoma.
- Brain Pathol. 1999 Apr;9(2):199-208. Unique Identifier : AIDSLINE MED/99235143
- Antinori A; Larocca LM; Fassone L; Cattani P; Capello D; Cingolani A; Saglio G; Fadda G; Gaidano G; Ortona L; Department of Infectious Diseases, Catholic University, Roma,; Italy. iclmi@rm.unicatt.it
- Primary central nervous system lymphoma (PCNSL) is a major complication of the late stages of human immunodeficiency virus (HIV) disease. Epstein Barr virus (EBV) infection is the only genetic lesion consistently associated with this neoplasia. Recently, it has been proposed that the pathogenesis of AIDS-related PCNSL
- Cortical synaptic density is reduced in mild to moderate human immunodeficiency virus neurocognitive disorder. HNRC Group. HIV Neurobehavioral Research Center.
- Brain Pathol. 1999 Apr;9(2):209-17. Unique Identifier : AIDSLINE MED/99235144
- Everall IP; Heaton RK; Marcotte TD; Ellis RJ; McCutchan JA; Atkinson JH; Grant I; Mallory M; Masliah E; Department of Neuropathology, Institute of Psychiatry, London,; UK.
- Dendritic and synaptic damage (without frank neuronal loss) may be seen in milder human immunodeficiency virus (HIV)-related cognitive disorders. Synapse volume estimates, performed by stereological methods, could enhance the ability to detect subtle neuronal changes that may accompany cognitive impairment in HIV infe
- Oligoclonal T cells in human cancer.
- Med Oncol. 1998 Dec;15(4):203-11. Unique Identifier : AIDSLINE MED/99136858
- Halapi E; deCODE Genetics Inc., Reykjavik, Iceland. evah@decode.is
- Many solid tumors are characterised by the infiltration of lymphocytes and their presence has been correlated with a more favourable prognosis. These tumor-infiltrating lymphocytes (TIL), have been shown to possess specific cytolytic reactivity towards autologous tumours, thus suggesting that tumour cells may express
- Multiple drug resistant tuberculosis: aetiology, diagnosis and outcome.
- Br Med Bull. 1998;54(3):569-78. Unique Identifier : AIDSLINE MED/99258135
- Eltringham IJ; Drobniewski F; Mycobacterial Reference Unit, PHL Dulwich, Dulwich Hospital,; London, UK.
- Tuberculosis is an increasing problem worldwide both in terms of disease burden and resistance to conventional antibiotic therapy. Studies of outbreaks involving resistant strains have highlighted the need for both improved infection control and the rapid provision of accurate susceptibility data. Each patient should
- Resurgence of tuberculosis and the impact of HIV infection.
- Br Med Bull. 1998;54(3):579-93. Unique Identifier : AIDSLINE MED/99258136
- Glynn JR; Department of Infectious and Tropical Diseases, London School of; Hygiene and Tropical Medicine, London, UK.
- Tuberculosis is increasing in many countries. In some areas the major influences on tuberculosis trends are the traditional ones: poverty, failures in the treatment system, and immigration. In others, and increasingly, the HIV epidemic is having a huge impact. HIV infection increases the risk of tuberculosis approxima
- HIV and sexually transmitted disease.
- Br Med Bull. 1998;54(3):717-29. Unique Identifier : AIDSLINE MED/99258146
- Weber J; Section of Infectious Diseases, Imperial College School of; Medicine, St Mary's Hospital, London, UK.
- Frequency of oropharyngeal candidiasis in HIV-infected patients on protease inhibitor therapy.
- Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Apr;87(4):437-41. Unique Identifier : AIDSLINE MED/99240155
- Diz Dios P; Ocampo A; Miralles C; Otero I; Iglesias I; Rayo N; Special Needs Unit, School of Medicine and Dentistry, Santiago de; Compostela University, Vigo, Spain.
- OBJECTIVE: The purpose of this study was to investigate the effect of HIV-1 protease inhibitors on the frequency of oropharyngeal candidiasis in HIV-infected patients. STUDY DESIGN: A clinical and analytic follow-up was carried out to determine the number of episode
- Using a pharmacist's progress-note form to manage HIV pharmacotherapy.
- Am J Health Syst Pharm. 1999 Mar 1;56(5):420-1. Unique Identifier : AIDSLINE MED/99194363
- Geletko S; Small FJ; Pinon M; Department of Pharmacy, Veterans Affairs Medical Center,; University of Rhode Island, Providence 02908, USA.
- Reduced IL-12 level correlates with decreased IFN-gamma secreting T cells but not natural killer cell activity in asthmatic children.
- Ann Allergy Asthma Immunol. 1999 May;82(5):479-84. Unique Identifier : AIDSLINE MED/99280020
- Chou CC; Huang MS; Hsieh KH; Chiang BL; Department of Pediatrics, College of Medicine, National Taiwan; University, Taipei, ROC.
- BACKGROUND: Accessory cells such as macrophages and natural killer cells, and their cytokines such as IL-10, IL-12, and IFN-gamma have been suggested to play a critical role in the development of T helper cells. OBJECTIVE: Both natural killer cells and peripheral blood mononuclear cells were isolated and stimulated fo
- Isolation of efficient antivirals: genetic suppressor elements against HIV-1.
- Gene Ther. 1999 Jan;6(1):130-7. Unique Identifier : AIDSLINE MED/99273431
- Dunn SJ; Park SW; Sharma V; Raghu G; Simone JM; Tavassoli R; Young LM; Ortega MA; Pan CH; Alegre GJ; Roninson IB; Lipkina G; Dayn A; Holzmayer TA; Ingenex Inc, Menlo Park, CA, USA.
- The development of general approaches for the isolation of efficient antivirals and the identification and validation of targets for drug screening are becoming increasingly important, due to the emergence of previously unrecognized viral diseases. The genetic suppressor element (GSE) technology is an approach based o
- Transplantation of transduced nonhuman primate CD34+ cells using a gibbon ape leukemia virus vector: restricted expression of the gibbon ape leukemia virus receptor to a subset of CD34+ cells.
- Gene Ther. 1999 Jan;6(1):48-56. Unique Identifier : AIDSLINE MED/99273421
- Bunnell BA; Kluge KA; Lee-Lin SQ; Byrne ER; Orlic D; Metzger ME; Agricola BA; Wersto RP; Bodine DM; Morgan RA; Donahue RE; Clinical Gene Therapy Branch, National Human Genome Research; Institute, National Institutes of Health, Bethesda, MD, USA.
- The transduction efficiencies of immunoselected rhesus macaque (Macaca mulatta) CD34+ cells and colony-forming progenitor cells based on polymerase chain reaction (PCR) analysis were comparable for an amphotropic Moloney murine leukemia virus (MLV) retroviral vector and a retroviral vector derived from the gibbon ape
- Surgical repair of retinal detachment secondary to cytomegalovirus retinitis.
- Unique Identifier : AIDSLINE MED/99233417
- Stier PA; Glazer LC; Garretson BR; Deutsch TA
- BACKGROUND AND OBJECTIVE: This study was conducted to determine preoperative predictors of postoperative visual acuity in patients with acquired immunodeficiency syndrome (AIDS) and cytomegalovirus ( CMV ) retinitis and retinal
- Activation of macrophages and B lymphocytes by an oligodeoxynucleotide derived from an acutely pathogenic simian immunodeficiency virus.
- Antisense Nucleic Acid Drug Dev. 1998 Oct;8(5):357-70. Unique Identifier : AIDSLINE MED/99041636
- Lapatschek MS; Gilbert RL; Wagner H; Miethke T; Institute of Medical Microbiology, Immunology and Hygiene of the; Technical University of Munich, Germany.
- Certain CpG-containing DNA sequences from bacteria, viruses, or invertebrates elicit responses in the vertebrate innate immune system. These responses also account for many nonspecific effects of oligodeoxynucleotides used for antisense approaches. Here we describe a sequence from an acutely pathogenic simian immunode
- 3'-End modification of the adenoviral VA1 gene affects its expression in human cells: consequences for the design of chimeric VA1 RNA ribozymes.
- Antisense Nucleic Acid Drug Dev. 1998 Oct;8(5):379-90. Unique Identifier : AIDSLINE MED/99041638
- Barcellini-Couget S; Fenard D; Bertrand E; Singer RH; Lefebvre JC; Doglio A; Laboratoire de Virologie, Faculte de Medecine, Nice, France.
- Polymerase III (pol III)-dependent genes, like the adenoviral VA1 gene, are of particular interest for expressing small therapeutic RNAs into cells. A new VA1 RNA carrier molecule was generated through the deletion of the VA1 RNA central domain to give rise to the VAdeltaIV RNA vector that was devoid of undesirable ph
- Photodynamic therapy-mediated immune response against subcutaneous mouse tumors.
- Cancer Res. 1999 Apr 15;59(8):1941-6. Unique Identifier : AIDSLINE MED/99228518
- Korbelik M; Dougherty GJ; Cancer Imaging Department, British Columbia Cancer Agency,; Vancouver, Canada. mkorbeli@bccancer.bc.ca
- The curative ability of photodynamic therapy (PDT) is severely compromised if treated tumors are growing in immunodeficient hosts. Reconstitution of severe combined immunodeficient (scid) mice with splenocytes from naive immunologically intact BALB/c mice did not improve the response to Photofrin-based PDT of EMT6 tum
- [Subtype and sequence analysis of the C2-V3 region of gp120 genes among HIV-1 strains in Sichuan province]
- Chung Hua Liu Hsing Ping Hsueh Tsa Chih. 1998 Feb;19(1):39-42. Unique Identifier : AIDSLINE MED/99256017
- Qin G; Shao Y; Liu G; Sichuan Sanitation and Anti-epidemic Station, Chengdu.
- Nine DNA fragments of HIV-1 env gene were amplified by PCR from uncultured peripheral blood mononuclear cells (PBMCs) obtained from HIV-1 sero-positive intravenous drug users (IDUs) in Sichuan province, in mid 1996. Their C2-V3 region (about 450 bp) was sequenced. Sequence analysis showed that there were two HIV-1 sub
- [Epidemiological analysis of HIV infection status in the population at high risk]
- Chung Hua Liu Hsing Ping Hsueh Tsa Chih. 1998 Apr;19(2):81-3. Unique Identifier : AIDSLINE MED/99256025
- Wang D; Chu Q; Jiang Z; Anti-Epidemic Station of Qingdao, Shandong Province.
- In order to understand the status of HIV infection in the population under high risk, we conducted an epidemiological investigation among 396 persons from 1992 to 1995. The research sample included 55 female prostitutes, 159 labourers who had finished labour services abroad upon returning, 88 professional blood donors
- HIV/AIDS research priorities among aboriginal people in Canada.
- Rev Panam Salud Publica. 1999 Mar;5(3):207-9. Unique Identifier : AIDSLINE MED/99283745
- Lentiviral vectors and gene therapy.
- Front Biosci. 1999 Jun 1;4:D481-96. Unique Identifier : AIDSLINE MED/99282845
- Klimatcheva E; Rosenblatt JD; Planelles V; Departments of Medicine and Microbiology & Immunology, University; of Rochester Cancer Center, NY 14642, USA.
- Gene therapy is a novel method under investigation for the treatment of genetic, metabolic and neurologic diseases, cancer and AIDS. The primary goal of gene therapy is to deliver a specific gene to a pre-determined target cell, and to direct expression of such a gene in a manner which will result in a therapeutic eff
- Ribozymes in gene therapy of HIV-1.
- Front Biosci. 1999 Jun 1;4:D497-505. Unique Identifier : AIDSLINE MED/99282846
- Macpherson JL; Ely JA; Sun LQ; Symonds GP; Johnson & Johnson Research Laboratories, GPO Box 3331, Sydney,; NSW 2001 Australia.
- Human immunodeficiency virus type 1 (HIV-1) is the primary etiologic agent for Aquired Immune Deficiency Syndrome (AIDS). HIV-1 is a lentivirus, a separate genus of the Retroviridae, which are complex RNA viruses that integrate into the genome of host cells and replicate intracellularly. Ribozymes are catalytic RNA mo
- Efavirenz in the management of HIV infection.
- Int J Clin Pract. 1999 Jan-Feb;53(1):60-4. Unique Identifier : AIDSLINE MED/99275537
- Gazzard BG; Department of HIV and Genitourinary Medicine, Chelsea &; Westminster Hospital, London, UK.
- Efavirenz , which is likely to be licensed in the UK and throughout Europe shortly, represents a major advance in the treatment of HIV infection. It belongs to the non-nucleoside reverse transcriptase (NNRTI) class of drugs and, as such, it should only
- False-positive results in antenatal HIV screening [letter]
- CMAJ. 1999 May 4;160(9):1285. Unique Identifier : AIDSLINE MED/99266368
- Magee LA; Murphy KE; von Dadelszen P
- Compulsory HIV tests [letter]
- CMAJ. 1999 May 4;160(9):1286-7. Unique Identifier : AIDSLINE MED/99266369
- Dunn RW
- The impact of a split-second error.
- CMAJ. 1999 May 4;160(9):1351. Unique Identifier : AIDSLINE MED/99266385
- Thompson SK; Faculty of Medicine, University of Calgary.
- An important risk group. Managing occupational HIV exposure.
- Adv Nurse Pract. 1998 Nov;6(11):55-8, 60, 93. Unique Identifier : AIDSLINE MED/99117705
- Yeargin P
- Advancing safe nursing practices.
- Adv Nurse Pract. 1998 Nov;6(11):94. Unique Identifier : AIDSLINE MED/99117711
- Arnold L
- Hypoglycemic, anticomplement and anti-HIV activities of Spathodea campanulata stem bark.
- Phytomedicine. 1999 Mar;6(1):45-9. Unique Identifier : AIDSLINE MED/99245295
- Niyonzima G; Laekeman G; Witvrouw M; Van Poel B; Pieters L; Paper D; De Clercq E; Franz G; Vlietinck AJ; Department of Pharmaceutical Sciences, University of Antwerp; (UIA), Belgium.
- Spathodea campanulata stem bark decoction (SCD) has shown hypoglycemic activity in mice. It was separated by column chromatography into different fractions, which were evaluated for their hypoglycemic, anticomplement and anti-HIV activities. The most polar fraction exerted by far the most prominent effect in different
- Galloylpaeoniflorin, a new acylated monoterpene glucoside from paeony root.
- Arch Pharm Res. 1991 Mar;14(1):52-4. Unique Identifier : AIDSLINE MED/99252680
- Kang SS; Shin KH; Chi HJ; Natural Products Research Institute, Seoul National University,; Korea.
- A new acylated monoterpene glucoside, galloylpaeoniflorin, was isolated from Paeony root. The structure was determined by chemical and spectroscopic methods.
- Cell-dependent function of HIV-1 Vif for virus replication (Review).
- Int J Mol Med. 1999 May;3(5):473-6. Unique Identifier : AIDSLINE MED/99220020
- Inubushi R; Adachi A; Department of Virology, The University of Tokushima School of; Medicine, Tokushima 770-8503, Japan.
- It has been well established that the Vif protein of human immunodeficiency virus type 1 (HIV-1) acts late in the viral life cycle and increases the infectivity of the progeny virions in a producer cell-dependent manner. The virions produced in the absence of Vif in non-permissive cells (Delta Vif) are defective for a
- Characteristics of septic arthritis in human immunodeficiency virus-infected haemophiliacs versus other risk groups.
- Rheumatology (Oxford). 1999 Feb;38(2):139-42. Unique Identifier : AIDSLINE MED/99272054
- Barzilai A; Varon D; Martinowitz U; Heim M; Schulman S; The National Hemophilia Centre, Chaim Sheba Medical Center, Tel; Hashomer, Israel.
- The cases are presented of four haemophiliacs infected with human immunodeficiency virus (HIV) and with septic arthritis among the 340 patients followed at our centre. The data of these cases and 39 additional HIV-infected haemophiliacs with septic arthritis, identified in a literature search, are reviewed. The spectr
- Successful treatment of polyarteritis nodosa related to hepatitis B virus with a combination of lamivudine and interferon alpha [letter]
- Rheumatology (Oxford). 1999 Feb;38(2):183-5. Unique Identifier : AIDSLINE MED/99272063
- Wicki J; Olivieri J; Pizzolato G; Sarasin F; Guillevin L; Dayer JM; Chizzolini C
- Risk of HIV transmission [letter; comment]
- Clin Pediatr (Phila). 1998 Sep;37(9):581. Unique Identifier : AIDSLINE MED/98446421
- Tessman I
- Abstinence and safer sex HIV risk-reduction interventions for African-American adolescents.
- Clin Pediatr (Phila). 1999 Mar;38(3):184-7. Unique Identifier : AIDSLINE MED/99288686
- Braverman PK; St. Christopher's Hospital for Children.
- Infection control in the bronchoscopy suite. A review.
- Clin Chest Med. 1999 Mar;20(1):19-32, ix. Unique Identifier : AIDSLINE MED/99222428
- Mehta AC; Minai OA; Section of Bronchology, Cleveland Clinic Foundation, Ohio, USA.
- Bronchoscopy can occasionally transmit disease. Infection control in the bronchoscopy suite is especially important because of the risk of transmitting HIV or tuberculosis. Many case reports, patient series, and small studies have been published, but little comprehensive guidance is available for clinicians who wish tj
- Role of bronchoscopy in AIDS.
- Clin Chest Med. 1999 Mar;20(1):63-76. Unique Identifier : AIDSLINE MED/99222432
- Raoof S; Rosen MJ; Khan FA; Division of Pulmonary Medicine, Nassau County Medical Center,; East Meadow, New York, USA.
- The differential diagnosis of pulmonary disorders in the HIV-infected individual is broad. Clinical features and chest radiographs may point towards a diagnosis but cannot reliably establish one. It is important to know the conditions in which bronchoscopy, BAL, and TBB are likely to be diagnostic, just as it is to knj
- Human immunodeficiency virus-related risk behavior among Italian psychiatric inpatients.
- Compr Psychiatry. 1999 Mar-Apr;40(2):126-30. Unique Identifier : AIDSLINE MED/99178344
- Grassi L; Peron L; Ferri S; Pavanati M; Department of Medical Sciences of Communication and Behavior,; University of Ferrara and S. Anna Hospital, Italy.
- This study evaluated at-risk behavior for human immunodeficiency virus (HIV) infection among Italian psychiatric inpatients. One hundred patients with mental disorders consecutively admitted to an acute psychiatric unit over a 1-year period were studied using a self-report questionnaire. In these patients, 53.1% reporj
- Perianal diseases in HIV-positive patients compared with a seronegative population.
- Dis Colon Rectum. 1999 May;42(5):649-54. Unique Identifier : AIDSLINE MED/99274485
- Nadal SR; Manzione CR; Galvao VM; Salim VR; Speranzini MB; Department of Proctology of the Instituto de Infectologia Emilio; Ribas, Sao Paulo, Brazil.
- PURPOSE: The aim of this report was to present our cases showing the prevalence and cause of perianal diseases in human immunodeficiency virus-positive patients. METHODS: We compared 1,860 human immunodeficiency virus-positive patients to 1,350 human immunodeficiency virus-negative outpatients with perianal diseases, j
- Systemic levels of cytokines and GAD-specific autoantibodies isotypes in Chinese IDDM patients.
- Diabetes Res Clin Pract. 1999 Feb;43(2):127-35. Unique Identifier : AIDSLINE MED/99236854
- Ng WY; Thai AC; Lui KF; Yeo PP; Cheah JS; Department of Medicine, National University of Singapore,; Singapore. mdcngwy@nus.edu.sg
- It is not clear if a Th1/Th2 imbalance in Type 1 diabetes (insulin-dependent diabetes mellitus, IDDM) would lead to a particular antigen-specific IgG subclass dominant as had been shown in the mouse model. In new-onset Type 1 diabetics, an autoantibody response to glutamate decarboxylase (GADab) is frequently observedj
- Prolactin exerts hematopoietic growth-promoting effects in vivo and partially counteracts myelosuppression by azidothymidine.
- Exp Hematol. 1999 May;27(5):811-6. Unique Identifier : AIDSLINE MED/99270221
- Woody MA; Welniak LA; Sun R; Tian ZG; Henry M; Richards S; Raziuddin A; Longo DL; Murphy WJ; Laboratory of Leukocyte Biology, National Cancer; Institute-Frederick Cancer Research and Development Center, MD; 21702-1201, USA.
- Prolactin (PRL) is a neuroendocrine hormone that influences immune and hematopoietic development. The mechanism of action of this hormone in vivo remains unclear; therefore, we assessed the effects of PRL on hematopoiesis in vivo and in vitro. Normal resting mice were treated with 0, 1, 10, or 100 microg of recombinanj
- Lymphocyte subpopulations in intrauterine growth retardation in women with or without previous pregnancies.
- Eur J Obstet Gynecol Reprod Biol. 1999 Jan;82(1):23-7. Unique Identifier : AIDSLINE MED/99206698
- Bartha JL; Comino-Delgado R; Department of Obstetrics and Gynecology, University Hospital of; Puerto Real, Cadiz, Spain. jbarthar@sego.es
- OBJECTIVE: To evaluate lymphocyte subpopulations in pregnant women with intrauterine growth retardation (IUGR). STUDY DESIGN: Forty-two normotensive and healthy women with singleton pregnancies and intrauterine growth retardation were studied in the third trimester of pregnancy and compared with 42 normal pregnant womj
- Intestinal macrophages display reduced permissiveness to human immunodeficiency virus 1 and decreased surface CCR5.
- Gastroenterology. 1999 May;116(5):1043-53. Unique Identifier : AIDSLINE MED/99238878
- Li L; Meng G; Graham MF; Shaw GM; Smith PD; Division of Gastroenterology and Hepatology, Department of; Medicine, University of Alabama at Birmingham, USA.
- BACKGROUND & AIMS: Because the role of intestinal mononuclear cells in the pathogenesis of human immunodeficiency virus 1 (HIV-1) disease has not been elucidated, we determined the biological properties of HIV-1 infection in primary intestinal macrophages. METHODS: Mucosal macrophages purified from normal human jej
- Rapid mucosal CD4(+) T-cell depletion and enteropathy in simian immunodeficiency virus-infected rhesus macaques.
- Gastroenterology. 1999 May;116(5):1115-23. Unique Identifier : AIDSLINE MED/99238885
- Kewenig S; Schneider T; Hohloch K; Lampe-Dreyer K; Ullrich R; Stolte N; Stahl-Hennig C; Kaup FJ; Stallmach A; Zeitz M; Department of Internal Medicine II, Saarland University,; Homburg/Saar.
- BACKGROUND & AIMS: Human immunodeficiency virus (HIV) infection leads to severe immunologic and functional disturbances in the intestinal tract in late stages of the disease. Information on mucosal pathology directly after infection is limited. We characterized this early phase in rhesus macaques infected with simi
- Making end points meet.
- Gastroenterology. 1999 May;116(5):1266-7. Unique Identifier : AIDSLINE MED/99238907
- Koretz RL
- The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences.
- Genes Dev. 1999 May 1;13(9):1126-39. Unique Identifier : AIDSLINE GENBANK/AF112880
- Kang Y; Cullen BR; Department of Genetics, Duke University Medical Center, Durham,; North Carolina 27710, USA.
- The constitutive transport element (CTE) encoded by simian type D retroviruses directs unspliced viral RNAs into a nuclear export pathway that is congruent with the pathway used by cellular mRNAs. Here, we show that quail cells are refractory to CTE function but become highly permissive upon expression of the human Ta
- Geography of intestinal permeability and absorption.
- Gut. 1999 Apr;44(4):483-9. Unique Identifier : AIDSLINE MED/99177197
- Menzies IS; Zuckerman MJ; Nukajam WS; Somasundaram SG; Murphy B; Jenkins AP; Crane RS; Gregory GG; St Thomas's Hospital, Lambeth Palace Road, London SE1 7EH, UK.
- BACKGROUND: Intestinal morphology and function vary geographically. AIMS: These functions were assessed in asymptomatic volunteers in European, North American, Middle Eastern, Asian, African, and Caribbean countries. METHODS: Five hour urine collections were obtained from each subject following ingestion of a 100 ml i
- The role of CTLA-4 in the regulation of T cell immune responses.
- Immunol Cell Biol. 1999 Feb;77(1):1-10. Unique Identifier : AIDSLINE MED/99201896
- McCoy KD; Le Gros G; Malaghan Institute of Medical Research, Wellington School of; Medicine, New Zealand. McCoyK@pathol.unizh.ch
- Over the past few years a great deal of research has examined how T cell-dependent immune responses are initiated and subsequently regulated. Ligation of the TCR with an antigenic peptide bound to an MHC protein on a professional APC provides the crucial antigen-specific stimulus required for T cell activation. Intera
- Isolation and characterization of monoclonal antibodies directed against murine FRP-1/CD98/4F2 heavy chain: murine FRP-1 is an alloantigen and amino acid change at 129 (P<-->R) is related to the alloantigenicity.
- Immunol Cell Biol. 1999 Feb;77(1):19-27. Unique Identifier : AIDSLINE MED/99201898
- Tsumura H; Kawano M; Tajima M; Kusaura T; Kozuka Y; Yoshimura S; Komada H; Tsurudome M; Nishio M; Kusagawa S; Shimura K; Ito Y; Department of Microbiology, Mie University School of Medicine,; Mie-ken, Japan. tsumura@doc.medic.mie-u.ac.jp
- Nineteen mAb directed against murine fusion regulatory protein-1 (mFRP-1)/4F2/CD98 were isolated and their biological properties were analysed. Intriguingly, mFRP-1 was found to be an alloantigen, namely, FRP-1.1 (DBA/2 and CBA mice type) and FRP-1.2 (BALB/c, C57BL/6 and C3H/He mice type). The nucleotide sequences of
- Does HIV cause depletion of CD4+ T cells in vivo by the induction of apoptosis?
- Immunol Cell Biol. 1999 Feb;77(1):90-8. Unique Identifier : AIDSLINE MED/99201906
- Jaworowski A; Crowe SM; AIDS Pathogenesis Research Unit, Macfarlane Burnet Centre for; Medical Research, National Centre for HIV Virology Research,; Fairfield, Victoria, Australia. anthonyj@burnet.edu.au
- The central pathogenic feature of AIDS is the dramatic loss of CD4+ lymphocytes. Despite more than a decade of intense research, the exact mechanism by which HIV causes this is still not understood. A major model for T cell depletion, proposed originally by Ameison and Capron in a report published in 1991, is that HIV
- Endemic mycoses: a treatment update.
- J Antimicrob Chemother. 1999 Mar;43(3):321-31. Unique Identifier : AIDSLINE MED/99238102
- Lortholary O; Denning DW; Dupont B; Service de Medecine Interne, Centre de Recherche en Pathologie; Infectieuse et Tropicale, Hopital Avicenne, Universite Paris; Nord, Bobigny, France. olortho@pasteur.fr
- Endemic mycoses remain a major public health problem in several countries and they are becoming increasingly frequent with the spread of HIV infection. Amphotericin B remains the drug of choice during the acute stage of life-threatening endemic mycoses occurring in both immunocompetent and immunocompromised hosts. Ket
- Are HIV-infected patients with rapid CD4 cell decline a subgroup who benefit from early antiretroviral therapy?
- J Antimicrob Chemother. 1999 Mar;43(3):379-88. Unique Identifier : AIDSLINE MED/99238110
- Easterbrook PJ; Goodall RL; Babiker AG; Yu LM; Smith D; Cooper DA; Gazzard BG; Chelsea and Westminster Hospital, London, UK.
- We have developed a model to determine whether asymptomatic HIV-infected individuals who have a rapid CD4 cell decline are a subgroup who might benefit from early antiretroviral therapy. Data were obtained from a subgroup of participants in the Concorde and EACG020 trials, two randomized, double-blind, comparative tri
- Non-albicans oral candidosis in HIV-positive patients.
- J Antimicrob Chemother. 1999 Mar;43(3):419-22. Unique Identifier : AIDSLINE MED/99238117
- Cartledge JD; Midgley J; Gazzard BG; Department of HIV and Genitourinary Medicine, St Stephen's; Centre, Chelsea and Westminster Hospital, London, UK.
- Specimens from HIV-positive patients with oral candidosis were taken for culture, species identification and azole susceptibility testing, which was correlated with treatment outcome. Of 921 specimens, 95 yielded non-albicans species, mainly from patients with low CD4 lymphocyte counts and extensive previous azole exp
- Initial increase in blood CD4(+) lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues.
- J Clin Invest. 1999 May 15;103(10):1391-8. Unique Identifier : AIDSLINE MED/99264342
- Bucy RP; Hockett RD; Derdeyn CA; Saag MS; Squires K; Sillers M; Mitsuyasu RT; Kilby JM; Department of Pathology, University of Alabama-Birmingham,; Birmingham, Alabama 35233-7331, USA. Bucy@uab.edu
- Previous studies proposed a dynamic, steady-state relationship between HIV-mediated cell killing and T-cell proliferation, whereby highly active antiretroviral therapy (HAART) blocks viral replication and tips the balance toward CD4(+) cell repopulation. In this report, we have analyzed blood and lymph node tissues ob
- Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma.
- J Clin Invest. 1999 May;103(9):1353-61. Unique Identifier : AIDSLINE MED/99242633
- Sampath D; Castro M; Look DC; Holtzman MJ; Department of Medicine, Washington University School of Medicine,; St. Louis, Missouri 63110, USA.
- Cytokine effects on immunity and inflammation often depend on the transcription factors termed signal transducers and activators of transcription (STATs), so STAT signaling pathways are candidates for influencing inflammatory disease. We reasoned that selective IFN responsiveness of the first STAT family member (Stat1
- Kinetics of T-cell development of umbilical cord blood transplantation in severe T-cell immunodeficiency disorders.
- J Allergy Clin Immunol. 1999 May;103(5 Pt 1):823-32. Unique Identifier : AIDSLINE MED/99262550
- Knutsen AP; Wall DA; Divisions of Allergy/Immunology and Hematology/Oncology/Bone; Marrow Transplantation, Department of Pediatrics, Saint Louis; University Health Sciences Center and Cardinal Glennon Children's; Hospital, St Louis, MO, USA.
- BACKGROUND: Hematopoietic stem-cell transplantation is the treatment of choice for severe primary T-cell immunodeficiencies. When an HLA-identical sibling donor is not available, an alternative donor stem-cell source is needed. In primary T-cell immunodeficiencies, T-cell-depleted HLA-haploidentical bone marrow transp
- Atopy, anergic status, and cytokine expression in HIV-infected subjects.
- J Allergy Clin Immunol. 1999 May;103(5 Pt 1):833-42. Unique Identifier : AIDSLINE MED/99262551
- Empson M; Bishop GA; Nightingale B; Garsia R; Department of Clinical Immunology, Royal Prince Alfred Hospital,; Camperdown, Australia.
- BACKGROUND: In HIV infection T-cell dysfunction resulting in anergy and hypersensitivity reactions precedes T-cell depletion. A shift in the cytokine profile from a type 1 to a type 2 response has been postulated. OBJECTIVE: We sought to examine the cytokine expression patterns in HIV infection and the relationship to
- Long-term immunologic effects of thymectomy in patients with myasthenia gravis.
- J Allergy Clin Immunol. 1999 May;103(5 Pt 1):865-72. Unique Identifier : AIDSLINE MED/99262555
- Gerli R; Paganelli R; Cossarizza A; Muscat C; Piccolo G; Barbieri D; Mariotti S; Monti D; Bistoni O; Raiola E; Venanzi FM; Bertotto A; Franceschi C; Section of Internal Medicine and Oncological Sciences (Center for; the Study of Rheumatic Diseases), University of Perugia, Italy.
- BACKGROUND: Thymectomy (Tx) is a common therapeutic option to treat myasthenia gravis (MG), but its effects on the immune system are still obscure in humans. OBJECTIVE: We sought to evaluate long-term immunologic effects of therapeutic Tx in patients with MG. METHODS: T- and B-cell subsets and T-cell repertoire were a
- Reproductive health needs: comparing women at high, drug-related risk of HIV with a national sample.
- J Am Med Womens Assoc. 1999 Spring;54(2):65-70, 78. Unique Identifier : AIDSLINE MED/99253152
- Armstrong KA; Kennedy MG; Kline A; Tunstall C; Division of HIV/AIDS Prevention, Centers for Disease Control and; Prevention in Atlanta, USA.
- Women who inject drugs or have injection drug-using sex partners are at high risk of acquiring human immunodeficiency virus (HIV) infection and of transmitting HIV perinatally. Many of these women need standard reproductive health care services, specialized HIV care, pre- and postnatal care, and drug treatment, but th
- Sexual practices in a cohort of US women with and without human immunodeficiency virus. HERS Study. HIV Epidemiology Research Study.
- J Am Med Womens Assoc. 1999 Spring;54(2):79-83. Unique Identifier : AIDSLINE MED/99253154
- Zierler S; Mayer K; Moore J; Stein M; Schoenbaum E; Schuman P; Rompalo A; AIDS Program, Brown University.
- OBJECTIVES: To compare the frequency and pattern of sexual activities of women infected with human immunodeficiency virus (HIV) relative to uninfected women at the time of enrollment into a multisite cohort study. METHODS: The HIV Epidemiology Research Study (HERS) is a prospective study following 873 HIV-infected and
- Long-term follow-up of a randomized trial of interferon therapy for chronic hepatitis B in a predominantly homosexual male population.
- J Hepatol. 1999 Apr;30(4):557-63. Unique Identifier : AIDSLINE MED/99224202
- Chen DK; Yim C; O'Rourke K; Krajden M; Wong DK; Heathcote EJ; Department of Medicine, Toronto Hospital, University of Toronto,; Ontario, Canada.
- BACKGROUND/AIMS: Extended follow-up of a previously published therapeutic trial with interferon alfa is now available to further clarify the long-term outcome of HIV-negative and HIV-positive subjects with chronic hepatitis B virus infection after interferon alfa therapy. METHODS: Forty-five subjects with compensated
- High pre-treatment serum hepatitis B virus titre predicts failure of lamivudine prophylaxis and graft re-infection after liver transplantation.
- J Hepatol. 1999 Apr;30(4):715-21. Unique Identifier : AIDSLINE MED/99224222
- Mutimer D; Pillay D; Dragon E; Tang H; Ahmed M; O'Donnell K; Shaw J; Burroughs N; Rand D; Cane P; Martin B; Buchan S; Boxall E; Barmat S; Gutekunst K; McMaster P; Elias E; Liver and Hepatobiliary Unit, Queen Elizabeth Hospital,; Birmingham, UK.
- BACKGROUND/AIMS: Orthotopic liver transplantation has an established role for the treatment of patients with chronic liver failure secondary to hepatitis B virus (HBV) infection. Unfortunately, recurrent infection of the graft can be associated with aggressive disease, and with diminished graft and patient survival. C
- Epidemiology of device-associated infections related to a long-term implantable vascular access device.
- Infect Control Hosp Epidemiol. 1999 Mar;20(3):187-91. Unique Identifier : AIDSLINE MED/99198644
- Sotir MJ; Lewis C; Bisher EW; Ray SM; Soucie JM; Blumberg HM; Department of Medicine, Emory University School of Medicine,; Atlanta, GA 30303, USA.
- OBJECTIVE: To examine risk factors for, and determine the incidence of, device-associated infections among patients with an implantable vascular access device. SETTING: Grady Health System, including a 1,000-bed, inner-city, public, teaching hospital and human immunodeficiency virus (HIV), oncology, and sickle cell cl
- Prevalence and changes in hepatitis C virus genotypes among multitransfused persons with hemophilia. The Multicenter Hemophilia Cohort Study.
- J Infect Dis. 1999 May;179(5):1062-9. Unique Identifier : AIDSLINE MED/99208683
- Eyster ME; Sherman KE; Goedert JJ; Katsoulidou A; Hatzakis A; The Pennsylvania State University College of Medicine, Division; of Hematology/Oncology HO46, Hershey, PA 17033l, USA.; eeyster@psghs.edu
- The purpose of this study was to determine hepatitis C virus (HCV) genotypes and their relationship to HCV RNA levels over time in a cohort of multitransfused hemophiliacs. Following reverse transcription and polymerase chain reaction amplification of HCV RNA, the product DNAs were genotyped by using the line probe as
- Early acquisition of TT virus (TTV) in an area endemic for TTV infection.
- J Infect Dis. 1999 May;179(5):1070-6. Unique Identifier : AIDSLINE GENBANK/AF113994
- Davidson F; MacDonald D; Mokili JL; Prescott LE; Graham S; Simmonds P; Edinburgh and South East Scotland Blood Transfusion Service,; University of Edinburgh, Edinburgh, EH8 9AH United Kingdom.
- TT virus (TTV) is widely distributed, with high frequencies of viremia in South America, Central Africa, and Papua New Guinea . The incidence and timing of infection in children born in a rural area of the Democratic Republic of Cong
- Expression of the late cytomegalovirus (CMV) pp150 transcript in leukocytes of AIDS patients is associated with a high viral DNA load in leukocytes and presence of CMV DNA in plasma.
- J Infect Dis. 1999 May;179(5):1101-7. Unique Identifier : AIDSLINE MED/99208688
- Boivin G; Handfield J; Toma E; Lalonde R; Bergeron MG; Division of Microbiology and Research Center in Infectious; Diseases, Centre Hospitalier Universitaire de Quebec, Pavillon; CHUL, Sainte-Foy, Quebec, Canada G1V 4G2.; guy.bovin@crchul.ulaval.ca
- The expression of a late cytomegalovirus ( CMV ) transcript (pp150) was sought in peripheral blood leukocytes (PBL) of subjects with AIDS and correlated with the amounts of CMV DNA in PBL and plasma, by means of quantitative po
- Antiviral effect and pharmacokinetic interaction between nevirapine and indinavir in persons infected with human immunodeficiency virus type 1.
- J Infect Dis. 1999 May;179(5):1116-23. Unique Identifier : AIDSLINE MED/99208690
- Murphy RL; Sommadossi JP; Lamson M; Hall DB; Myers M; Dusek A; Division of Infectious Diseases, Department of; Medicine,Northwestern University, Chicago, IL 60611, USA.; r-murphy@nwu.edu
- Nevirapine and indinavir have the potential of affecting the pharmacokinetics of each other. In a prospective trial, 24 human immunodeficiency virus (HIV)-infected subjects on stable nucleoside or no therapy were treated with 800 mg of indinavir every
- Detection of intracellular antigen-specific cytokines in human T cell populations.
- J Infect Dis. 1999 May;179(5):1124-31. Unique Identifier : AIDSLINE MED/99208691
- Kallas EG; Gibbons DC; Soucier H; Fitzgerald T; Treanor JJ; Evans TG; Infectious Diseases Unit, University of Rochester, Rochester, NY; 14642, USA.
- Determination of antigen-specific cytokine responses of T lymphocytes after vaccination is made difficult by the low frequency of responder cells. In order to detect these responses, the profile of intracellular cytokines was analyzed using flow cytometry after antigenic expansion. Peripheral blood mononuclear cells w
- Cytomegalovirus (CMV) retinitis activity is accurately reflected by the presence and level of CMV DNA in aqueous humor and vitreous.
- Unique Identifier : AIDSLINE MED/99208709
- Smith IL; Macdonald JC
- Hepatitis C virus is related to progressive liver disease in human immunodeficiency virus-positive hemophiliacs and should be treated as an opportunistic infection.
- J Infect Dis. 1999 May;179(5):1254-8. Unique Identifier : AIDSLINE MED/99208710
- Lesens O; Deschenes M; Steben M; Belanger G; Tsoukas CM; Immune Deficiency Treatment Center, Montreal General Hospital,; Montreal, Quebec, Canada H3G 1A4.
- The hypothesis was investigated that hepatitis C virus (HCV) infection behaves like an opportunistic infection in which progressive liver disease (PLD) is the principal manifestation. PLD in 81 hemophiliacs coinfected with HCV and human immunodeficiency virus (HIV) was compared with 53 HIV-seronegative HCV-infected he
- Genotypic resistance and the treatment of HIV-1 infection in Espirito Santo, Brazil.
- J Infect Dis. 1999 May;179(5):1259-63. Unique Identifier : AIDSLINE MED/99208711
- Pilcher CD; Perkins MD; Fiscus SA; Johnston DM; Dietze R; Duque UH; Zago AM; Assad-Antunes F; Eron JJ; Division of Infectious Diseases, Department of Medicine,; University of North Carolina-Chapel Hill, Chapel Hill, NC; 27599-7030, USA. p208470@med.unc.edu
- Before December 1997, in Espirito Santo, Brazil , combination antiretroviral therapy was used without routine virologic or immunologic monitoring. To examine consequences of therapy in this setting, clinical information, human immunodeficiency virus type 1 (HIV-1) RNA levels, CD4 ce
- Neutralization escape in human immunodeficiency virus type 1-infected long-term nonprogressors.
- J Infect Dis. 1999 May;179(5):1264-7. Unique Identifier : AIDSLINE MED/99208712
- Bradney AP; Scheer S; Crawford JM; Buchbinder SP; Montefiori DC; Department of Surgery, Duke University Medical Center, Durham, NC; 27710, USA.
- Neutralization-escape variants of human immunodeficiency virus type 1 (HIV-1) were sought in persons who had persistent low virus loads and who remained asymptomatic for at least 12-16 years of infection without antiretroviral therapy. Viruses were isolated from 3 persons at two or three time points during the course
- Comparison between a whole blood interferon-gamma release assay and tuberculin skin testing for the detection of tuberculosis infection among patients at risk for tuberculosis exposure.
- J Infect Dis. 1999 May;179(5):1297-300. Unique Identifier : AIDSLINE MED/99208719
- Kimura M; Converse PJ; Astemborski J; Rothel JS; Vlahov D; Comstock GW; Graham NM; Chaisson RE; Bishai WR; Department of Epidemiology, Johns Hopkins School of Public; Health, Baltimore, MD 21205, USA. mkimura@jhsph.edu
- A new test that measures interferon-gamma (IFN-gamma) release in whole blood following stimulation with tuberculin has the potential to detect tuberculosis infection using a single blood draw. The IFN-gamma release assay was compared with the standard tuberculin skin test (TST) among 467 intravenous drug users at risk
- CCR5 genotype and human immunodeficiency virus (HIV)-specific mucosal antibody in seronegative women at high risk for HIV infection [letter]
- J Infect Dis. 1999 May;179(5):1310-2. Unique Identifier : AIDSLINE MED/99208724
- Williams SB; Flanigan TP; Artenstein AW; VanCott TC; Smith D; Mayer K; Koup RA
- The taming of IL-12: suppressing the production of proinflammatory cytokines.
- J Leukoc Biol. 1999 May;65(5):543-51. Unique Identifier : AIDSLINE MED/99260324
- Sutterwala FS; Mosser DM; Department of Microbiology and Immunology, Temple University; School of Medicine, Philadelphia, Pennsylvania 19140, USA.
- Interleukin (IL)-12 is a cytokine that possesses both proinflammatory and immunoregulatory activity. IL-12, and the interferon-gamma (IFN-gamma) that is induced by IL-12, play central roles in the development of the Th1-type immune responses that are required for immunity to intracellular pathogens. Recently a number
- Chemokine immunobiology in HIV-1 pathogenesis.
- J Leukoc Biol. 1999 May;65(5):552-65. Unique Identifier : AIDSLINE MED/99260325
- Lee B; Montaner LJ; The Wistar Institute, Hospital of the University of Pennsylvania,; Department of Pathology & Laboratory Medicine, Philadelphia, USA.
- The discovery of HIV-1-suppressive chemokines and the subsequent discovery of their cognate receptors as coreceptors for HIV-1 entry herald a paradigmatic shift in the study of HIV-1 pathogenesis. The presence of polymorphisms in chemokine receptor and chemokine genes associated with altered progression and susceptibi
- Generation of CD28- cells from long-term-stimulated CD8+CD28+ T cells: a possible mechanism accounting for the increased number of CD8+CD28- T cells in HIV-1-infected patients.
- J Leukoc Biol. 1999 May;65(5):641-8. Unique Identifier : AIDSLINE MED/99260336
- Fiorentini S; Malacarne F; Ricotta D; Licenziati S; Solis AA; Ausenda S; De Francesco M; Garrafa E; Simonini A; Imberti L; Balsari A; Turano A; Caruso A; Institute of Microbiology, Department of Experimental and Applied; Medicine, Brescia Medical School, Italy.
- According to CD28 molecule expression, CD8+ T cells can be classed as CD28bright, CD28dim, and CD28-. The CD28dim T cells were found to derive from mitogenic stimulated CD28-T cells but also from CD28bright T cells through a mechanism of CD28 down-modulation. Moreover, after prolonged in vitro interleukin-2 stimulatio
- Superantigens augment antigen-specific Th1 responses by inducing IL-12 production in macrophages.
- J Leukoc Biol. 1999 May;65(5):665-70. Unique Identifier : AIDSLINE MED/99260339
- Bright JJ; Xin Z; Sriram S; Multiple Sclerosis Research Laboratory, Vanderbilt University; Medical Center, Nashville, Tennessee 37212, USA.
- Superantigens (SAg) are microbial proteins that mediate antigen-presenting cell (APC)-T cell interaction by cross-linking MHC class II molecules with subsets of TcRVbeta. SAgs are implicated in the pathogenesis of several infectious, inflammatory, and autoimmune diseases. In this study, we examined the influence of SE
- Assessment of chemokine receptor expression by human Th1 and Th2 cells in vitro and in vivo.
- J Leukoc Biol. 1999 May;65(5):691-9. Unique Identifier : AIDSLINE MED/99260343
- Annunziato F; Cosmi L; Galli G; Beltrame C; Romagnani P; Manetti R; Romagnani S; Maggi E; Institute of Internal Medicine and Immunoallergology, University; of Florence, Italy.
- The preferential association of some chemokine receptors with human Th1 or Th2 cells has recently been reported. In this study, the expression of CCR3, CCR5, CXCR3, and CXCR4 were analyzed by flow cytometry in three distinct in vitro models of Th1/Th2 polarization, activated naive and memory T cells, and T-cell clones
- HIV/AIDS in Pakistan: the context and magnitude of an emerging threat.
- J Epidemiol Community Health. 1998 Sep;52(9):579-85. Unique Identifier : AIDSLINE MED/99254162
- Hyder AA; Khan OA; Department of International Health, School of Hygiene and Public; Health, Johns Hopkins University, Baltimore, MD 21205, USA.
- STUDY OBJECTIVE: The objectives of this review were to: (1) assess the nature and comprehensiveness of information regarding HIV/AIDS in Pakistan ; (2) to evaluate the extent of HIV/AIDS in Pakistan by epidemiological estimates; (3) to indicate the implications of the results for
- Access to antiretroviral treatment among French HIV infected injection drug users: the influence of continued drug use. MANIF 2000 Study Group.
- J Epidemiol Community Health. 1999 Jan;53(1):4-8. Unique Identifier : AIDSLINE MED/99257895
- Carrieri MP; Moatti JP; Vlahov D; Obadia Y; Reynaud-Maurupt C; Chesney M; Data Management Service, Istituto Superiore di Sanita, Rome,; Italy.
- STUDY OBJECTIVE: To determine the influence of continued drug use and its perception by prescribing physicians on access to antiretroviral treatment among French HIV infected injection drug users (IDUs). DESIGN: Cross sectional including enrollment data (October 1995-1996) of the cohort study MANIF 2000. Access to tre
- Steady state assumptions in DALYs: effect on estimates of HIV impact.
- J Epidemiol Community Health. 1999 Jan;53(1):43-5. Unique Identifier : AIDSLINE MED/99257902
- Hyder AA; Morrow RH; Department of International Health, School of Public Health,; Johns Hopkins University, Baltimore, MD 21205, USA.
- OBJECTIVE: The disability adjusted life year (DALY) and the healthy life year (HeaLY) are both composite indicators of disease burden in a population, which combine healthy life lost from mortality and morbidity. The two formulations deal with the onset and course of a disease differently. The purpose of this paper is
- Developmental regulation of Lck targeting to the CD8 coreceptor controls signaling in naive and memory T cells.
- J Exp Med. 1999 May 17;189(10):1521-30. Unique Identifier : AIDSLINE MED/99265984
- Bachmann MF; Gallimore A; Linkert S; Cerundolo V; Lanzavecchia A; Kopf M; Viola A; Basel Institute for Immunology, CH-4005 Basel, Switzerland.
- The question of whether enhanced memory T cell responses are simply due to an increased frequency of specific cells or also to an improved response at the single cell level is widely debated. In this study, we analyzed T cell receptor (TCR) transgenic memory T cells and bona fide memory T cells isolated from virally i
- Constant mean viral copy number per infected cell in tissues regardless of high, low, or undetectable plasma HIV RNA.
- J Exp Med. 1999 May 17;189(10):1545-54. Unique Identifier : AIDSLINE MED/99265986
- Hockett RD; Kilby JM; Derdeyn CA; Saag MS; Sillers M; Squires K; Chiz S; Nowak MA; Shaw GM; Bucy RP; Department of Pathology, University of Alabama at Birmingham,; Birmingham, Alabama 35233-7331, USA.
- Quantitative analysis of the relationship between virus expression and disease outcome has been critical for understanding HIV-1 pathogenesis. Yet the amount of viral RNA contained within an HIV-expressing cell and the relationship between the number of virus-producing cells and plasma virus load has not been establis
- Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses.
- J Exp Med. 1999 May 17;189(10):1565-72. Unique Identifier : AIDSLINE MED/99265988
- McKenzie GJ; Fallon PG; Emson CL; Grencis RK; McKenzie AN; Medical Research Council Laboratory of Molecular Biology, Hills; Road, Cambridge CB2 2QH, United Kingdom.
- Using a single vector targeting strategy, we have generated mice with a combined deficiency of interleukin (IL)-4 and IL-13 to clarify their roles in T helper type 2 (Th2) cell responses. Using immunological challenges normally characterized by a Th2-like response, we have compared the responses of the double-deficien
- The composition of a primary T cell response is largely determined by the timing of recruitment of individual T cell clones.
- J Exp Med. 1999 May 17;189(10):1591-600. Unique Identifier : AIDSLINE MED/99265991
- Bousso P; Levraud JP; Kourilsky P; Abastado JP; Unite de Biologie Moleculaire du Gene, Institut National de la; Sante et de la Recherche Medicale U277 and Institut Pasteur,; 75724 Paris, France. bousso@pasteur.fr
- Primary T cell responses rely on the recruitment and proliferation of antigen-specific T cell precursors. The extent of expansion of each individual T cell clone may depend on (a) its frequency before immunization, (b) its proliferative capacity, and (c) the time at which it first encounters its cognate antigen. In th
- The role of beta7 integrins in CD8 T cell trafficking during an antiviral immune response.
- J Exp Med. 1999 May 17;189(10):1631-8. Unique Identifier : AIDSLINE MED/99265995
- Lefrancois L; Parker CM; Olson S; Muller W; Wagner N; Puddington L; Division of Rheumatic Diseases, University of Connecticut Health; Center, Farmington, Connecticut 06037, USA.
- The requirement of beta7 integrins for lymphocyte migration was examined during an ongoing immune response in vivo. Transgenic mice (OT-I) expressing an ovalbumin-specific major histocompatibility complex class I-restricted T cell receptor for antigen were rendered deficient in expression of all beta7 integrins or onl
- HIV-associated primary CNS lymorbidity and utility of brain biopsy.
- J Neurol Sci. 1999 Feb 1;163(1):32-8. Unique Identifier : AIDSLINE MED/99237918
- Skolasky RL; Dal Pan GJ; Olivi A; Lenz FA; Abrams RA; McArthur JC; Department of Neurology, Johns Hopkins University, Baltimore, MD; 21287-7609, USA.
- INTRODUCTION: Human immunodeficiency virus (HIV) infection is associated with several central nervous system (CNS) infections and neoplasms. These opportunistic processes generally occur with advanced immunosuppression, but if an accurate diagnosis is made, effective treatment can frequently be initiated. METHODS: In
- Predicting relative binding affinities of non-peptide HIV protease inhibitors with free energy perturbation calculations.
- J Comput Aided Mol Des. 1999 Mar;13(2):109-21. Unique Identifier : AIDSLINE MED/99191218
- McCarrick MA; Kollman PA; University of California at San Francisco 94143-0446, USA.
- The relative binding free energies in HIV protease of haloperidol thioketal (THK) and three of its derivatives were examined with free energy calculations. THK is a weak inhibitor (IC50 = 15 microM) for which two cocrystal structures with HIV type 1 proteases have been solved [Rutenber, E. et al., J. Biol. Chem., 268
- Major versus minor groove DNA binding of a bisarginylporphyrin hybrid molecule: a molecular mechanics investigation.
- J Comput Aided Mol Des. 1999 Mar;13(2):123-37. Unique Identifier : AIDSLINE MED/99191219
- Gresh N; Perree-Fauvet M; Laboratoire de Pharmacochimie Moleculaire et Structurale,; CNRS-URA 1500, INSERM U266, Universite Paris 5, France.
- On the basis of theoretical computations, we have recently synthesised [Perree-Fauvet, M. and Gresh, N., Tetrahedron Lett., 36 (1995) 4227] a bisarginyl conjugate of a tricationic porphyrin (BAP), designed to target, in the major groove of DNA, the d(GGC GCC)2 sequence which is part of the primary binding site of the
- Hospice Uganda: 1993-1998.
- J Palliat Care. 1999 Spring;15(1):50-2. Unique Identifier : AIDSLINE MED/99266207
- Merriman A; Hospice Uganda, Kampala, Uganda.
- Terminal HIV disease and extreme poverty: a review of 307 home care files.
- J Palliat Care. 1999 Spring;15(1):6-12. Unique Identifier : AIDSLINE MED/99266201
- Daneault S; Labadie JF; Public Health Department, Montreal Centre Region, Quebec, Canada.
- This retrospective study of 307 patients with advanced HIV disease residing in downtown Montreal was carried out to examine the nature and consequences of the services they received according to their degree of poverty. The findings showed that, between 1 April 1991 and 31 March 1997, patients living in extreme povert
- Simultaneous investigation of indinavir nonlinear pharmacokinetics and bioavailability in healthy volunteers using stable isotope labeling technique: study design and model-independent data analysis.
- Unique Identifier : AIDSLINE MED/99248252
- Yeh KC; Stone JA; Carides AD; Rolan P; Woolf E; Ju WD; Departments of Drug Metabolism and Biostatistics, Merck Research; Laboratories, West Point, Pennsylvania 19486, USA.; kuang_yeh@merck.com
- Indinavir follows nonlinear pharmacokinetics upon oral administration at clinical doses. A study employing the stable isotope administration technique in a three-treatment design was conducted to identify the source of the nonlinearity and to determin
- HIV infection: oral lesions, CD4+ cell count and viral load in an Italian study population.
- J Oral Pathol Med. 1999 Apr;28(4):173-7. Unique Identifier : AIDSLINE MED/99249450
- Margiotta V; Campisi G; Mancuso S; Accurso V; Abbadessa V; Department of Oral Medicine, University of Palermo, Italy.
- The aims of this study were to assess types and prevalence of HIV-related oral lesions and to correlate these lesions to the main laboratory parameters such as CD4+ cell count and plasma HIV-RNA. The study population consisted of 104 consecutive HIV+ patients living in Sicily (M=67, 64.4%; F=37, 35.6%; median age=35 y
- Paediatric AIDS--related linear gingival erythema: a form of erythematous candidiasis?
- J Oral Pathol Med. 1999 Apr;28(4):178-82. Unique Identifier : AIDSLINE MED/99249451
- Velegraki A; Nicolatou O; Theodoridou M; Mostrou G; Legakis NJ; Department of Microbiology, Medical School, University of Athens,; Greece.
- Three vertically HIV-infected children showed, in addition to oral candidiasis, HIV-gingivitis, which healed on antimycotic treatment. The intense linear gingival erythema of a fourth child was also clinically evaluated as a possible form of erythematous oral candidiasis. Direct microscopic examination of material fro
- Detection of Helicobacter pylori in oral aphthous ulcers.
- J Oral Pathol Med. 1999 May;28(5):197-203. Unique Identifier : AIDSLINE MED/99243528
- Birek C; Grandhi R; McNeill K; Singer D; Ficarra G; Bowden G; Faculty of Dentistry, University of Manitoba, Canada.
- A causative role for Helicobacter pylori (H. pylori) in the pathogenesis of oral mucosal ulcerations has been suggested previously. We have adopted the polymerase chain reaction (PCR) as a rapid and sensitive means to detect H. pylori in swabs of recurrent oral aphthous ulcers and in samples of other oral sites. Of th
- Oral ulcers in AIDS patients frequently associated with cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections.
- J Oral Pathol Med. 1999 May;28(5):204-9. Unique Identifier : AIDSLINE MED/99243529
- Syrjanen S; Leimola-Virtanen R; Schmidt-Westhausen A; Reichart PA; Department of Oral Pathology and Radiology, Faculty of Medicine,; University of Turku, Finland.
- Oral ulcers are common in AIDS patients, with a wide spectrum of underlying causes, including different viruses. In the present study, the presence of cytomegalovirus ( CMV ), Epstein-Barr virus (EBV) and human herpesvirus-8 (H
- Extension of the polyanionic cosalane pharmacophore as a strategy for increasing anti-HIV potency.
- J Med Chem. 1999 May 20;42(10):1767-77. Unique Identifier : AIDSLINE MED/99278602
- Cushman M; Insaf S; Paul G; Ruell JA; De Clercq E; Schols D; Pannecouque C; Witvrouw M; Schaeffer CA; Turpin JA; Williamson K; Rice WG; Department of Medicinal Chemistry, School of Pharmacy, Purdue; University, West Lafayette, Indiana 47907, USA.
- The anti-HIV agent cosalane inhibits both the binding of gp120 to CD4 as well as an undefined postattachment event prior to reverse transcription. Several cosalane analogues having an extended polyanionic pharmacophore were designed based on a hypothetical model of the binding of cosalane to CD4. The analogues were
- Structure-activity relationship of small-sized HIV protease inhibitors containing allophenylnorstatine.
- J Med Chem. 1999 May 20;42(10):1789-802. Unique Identifier : AIDSLINE MED/99278604
- Mimoto T; Kato R; Takaku H; Nojima S; Terashima K; Misawa S; Fukazawa T; Ueno T; Sato H; Shintani M; Kiso Y; Hayashi H; Pharmaceuticals & Biotechnology Laboratory, Japan Energy; Corporation, Toda-shi, Saitama 335-8502, Japan.
- We designed and synthesized a new class of peptidomimetic human immunodeficiency virus (HIV) protease inhibitors containing a unique unnatural amino acid, allophenylnorstatine [Apns; (2S, 3S)-3-amino-2-hydroxy-4-phenylbutyric acid], with a hydroxymethylcarbonyl (HMC
- Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives.
- Unique Identifier : AIDSLINE MED/99278606
- Moreau P; Anizon F; Sancelme M
- Mycobacterium avium infection in BALB/c and SCID mice.
- J Med Microbiol. 1999 Jun;48(6):577-83. Unique Identifier : AIDSLINE MED/99285840
- Fattorini L; Mattei M; Placido R; Li B; Iona E; Agrimi U; Colizzi V; Orefici G; Laboratory of Bacteriology and Medical Mycology, Istituto; Superiore di Sanita, Rome, Italy.
- BALB/c and severe combined immunodeficient (SCID) mice were inoculated intraperitoneally with Mycobacterium avium and the numbers of cfu were monitored for 70 days in spleen, liver, lung, kidney, brain and peritoneum. While BALB/c mice formed typical granulomas and controlled bacterial growth in organs, a delay in dev
- Fatal Campylobacter jejuni bacteraemia in patients with AIDS.
- J Med Microbiol. 1999 Jun;48(6):601-3. Unique Identifier : AIDSLINE MED/99285844
- Manfredi R; Nanetti A; Ferri M; Chiodo F; Dipartimento di Medicina Clinica Specialistica e Sperimentale,; Universita degli Studi di Bologna, Italy.
- Two fatal cases of Campylobacter jejuni septicaemia in patients with AIDS were characterised by severe HIV-related immunodeficiency, negative stool cultures and presentation during hospitalisation, developing a clinical picture of fulminant septic shock despite therapy with appropriate antibiotics. Campylobacter spp.
- Cyclin T1 domains involved in complex formation with Tat and TAR RNA are critical for tat-activation.
- J Mol Biol. 1999 Apr 23;288(1):41-56. Unique Identifier : AIDSLINE MED/99263518
- Ivanov D; Kwak YT; Nee E; Guo J; Garcia-Martinez LF; Gaynor RB; Division of Hematology-Oncology, Department of Medicine, Harold; Simmons Cancer Center, University of Texas Southwestern Medical; Center, Dallas, TX, 75235-8594, USA.
- Tat activates transcription from the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) by increasing the processivity of RNA polymerase II. Recently, it has been demonstrated that the cellular kinase CDK9 and its binding partner cyclin T1 are involved in regulating transcriptional elongation and t
- Role of the human and murine cyclin T proteins in regulating HIV-1 tat-activation.
- J Mol Biol. 1999 Apr 23;288(1):57-69. Unique Identifier : AIDSLINE MED/99263519
- Kwak YT; Ivanov D; Guo J; Nee E; Gaynor RB; Division of Hematology-Oncology, Department of Medicine, Harold; Simmons Cancer Center, University of Texas Southwestern Medical; Center, Dallas, TX, 75235-8594, USA.
- Human cyclin T1 markedly stimulates tat-activation in rodent cells which are normally poorly responsive to the effects of Tat. This result suggests that there are likely to be critical differences in the murine and human cyclin T1 proteins. Here, we analyzed the role of the murine and human cyclin T1 proteins in addit
- Reverse transcription of the yeast Ty1 retrotransposon: the mode of first strand transfer is either intermolecular or intramolecular.
- J Mol Biol. 1999 May 14;288(4):505-10. Unique Identifier : AIDSLINE MED/99264383
- Wilhelm M; Boutabout M; Heyman T; Wilhelm FX; Unite Propre de Recherches 9002 du Centre National de la; Recherche Scientifique, Institut de Biologie Moleculaire et; Cellulaire, 15 rue Rene Descartes, Strasbourg, 67084, France.; wilhelm@ibmc.u-strasbg.fr
- Replication of the yeast Ty1 retrotransposon occurs by a mechanism similar to that of retroviruses. According to the current model of retroviral reverse transcription, two strand transfers (the so-called minus-strand and plus-strand strong-stop DNA transfers) are required to produce full-length preintegrative DNA. Bec
- Redox and activation status of monocytes from human immunodeficiency virus-infected patients: relationship with viral load.
- Unique Identifier : AIDSLINE MED/99252144
- Elbim C; Pillet S; Prevost MH; Preira A; Girard PM; Rogine N; Matusani H; Hakim J; Israel N; Gougerot-Pocidalo MA
- Monocytes are precursors of tissue macrophages, which are major targets of human immunodeficiency virus type 1 (HIV-1) infection. Although few blood monocytes are infected, their resulting activation could play a key role in the pathogenesis of HIV disease by modulating their transendothelial migration and inducing th
- The role of human T-lymphotropic virus type 1 (HTLV-1)-infected dendritic cells in the development of HTLV-1-associated myelopathy/tropical spastic paraparesis.
- J Virol. 1999 Jun;73(6):4575-81. Unique Identifier : AIDSLINE MED/99252146
- Makino M; Shimokubo S; Wakamatsu SI; Izumo S; Baba M; Division of Human Retroviruses, Center for Chronic Viral; Diseases, Faculty of Medicine, Kagoshima University, Kagoshima; 890-8520, Japan. makino-m@cb3.so-net.ne.jp
- The development of human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is closely associated with the activation of T cells which are HTLV-1 specific but may cross-react with neural antigens (Ags). Immature dendritic cells (DCs), differentiated from normal donor mono
- Enhanced inhibition of human immunodeficiency virus type 1 by Met-stromal-derived factor 1beta correlates with down-modulation of CXCR4.
- J Virol. 1999 Jun;73(6):4582-9. Unique Identifier : AIDSLINE MED/99252147
- Yang OO; Swanberg SL; Lu Z; Dziejman M; McCoy J; Luster AD; Walker BD; Herrmann SH; AIDS Research Center and Infectious Disease Unit, Massachusetts; General Hospital, Charlestown, Massachusetts 02129, USA.
- CXCR4 is a chemokine receptor used by some strains of HIV-1 as an entry coreceptor in association with cell surface CD4 on human cells. In human immunodeficiency virus type 1 (HIV-1)-infected individuals, the appearance of viral isolates with a tropism for CXCR4 (T tropic) has been correlated with late disease progres
- Cross-subtype neutralizing antibodies induced in baboons by a subtype E gp120 immunogen based on an R5 primary human immunodeficiency virus type 1 envelope.
- J Virol. 1999 Jun;73(6):4640-50. Unique Identifier : AIDSLINE MED/99252153
- VanCott TC; Mascola JR; Loomis-Price LD; Sinangil F; Zitomersky N; McNeil J; Robb ML; Birx DL; Barnett S; Henry M. Jackson Foundation, Walter Reed Army Institute of; Research, Rockville, Maryland 20850, USA. tvancott@hiv.hjf.org
- Global human immunodeficiency virus type 1 (HIV-1) diversity may require engineering vaccines to express antigens representing strains prevalent in the target population of vaccine testing. The majority (90%) of incident infections in Thailand are genetic subtype E, with a small
- Proline residues in human immunodeficiency virus type 1 p6(Gag) exert a cell type-dependent effect on viral replication and virion incorporation of Pol proteins.
- J Virol. 1999 Jun;73(6):4696-704. Unique Identifier : AIDSLINE MED/99252159
- Dettenhofer M; Yu XF; Department of Molecular Microbiology and Immunology, Johns; Hopkins University School of Hygiene and Public Health,; Baltimore, Maryland 21205, USA.
- The C terminus of the HIV-1 Gag protein contains a proline-rich domain termed p6(Gag). This domain has been shown to play a role in efficient virus release and incorporation of Vpr into virions. In a previous study (X. F. Yu, L. Dawson, C. J. Tian, C. Flexner, and M. Dettenhofer, J. Virol. 72:3412-3417, 1998), we obse
- Reversion of a human immunodeficiency virus type 1 matrix mutation affecting Gag membrane binding, endogenous reverse transcriptase activity, and virus infectivity.
- J Virol. 1999 Jun;73(6):4728-37. Unique Identifier : AIDSLINE MED/99252163
- Kiernan RE; Ono A; Freed EO; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, Maryland 20892-0460, USA.
- We previously characterized mutations in the human immunodeficiency virus type 1 matrix (MA) protein that displayed reduced infectivity in single-round assays, defects in the stable synthesis of viral DNA in infected cells, and impaired endogenous reverse transcriptase activity. The mutants, which contained substituti
- Human herpesvirus 8-encoded thymidine kinase and phosphotransferase homologues confer sensitivity to ganciclovir.
- J Virol. 1999 Jun;73(6):4786-93. Unique Identifier : AIDSLINE MED/99252169
- Cannon JS; Hamzeh F; Moore S; Nicholas J; Ambinder RF; Departments of Pharmacology and Molecular Sciences, Johns Hopkins; University School of Medicine, Baltimore, Maryland, USA.
- Human herpesvirus 8 (HHV-8) sensitivity to the nucleoside analog ganciclovir (GCV) suggests the presence of a virally encoded kinase that catalyzes the initial phosphorylation of GCV. Analysis of the HHV-8 genome identified two candidate kinases: proteins encoded by open reading frame (ORF) 21, with homology to the he
- Molecular requirements for human immunodeficiency virus type 1 plus-strand transfer: analysis in reconstituted and endogenous reverse transcription systems.
- J Virol. 1999 Jun;73(6):4794-805. Unique Identifier : AIDSLINE MED/99252170
- Wu T; Guo J; Bess J; Henderson LE; Levin JG; Laboratory of Molecular Genetics, National Institute of Child; Health and Human Development, Bethesda, Maryland 20892, USA.
- We have developed a reconstituted system which models the events associated with human immunodeficiency virus type 1 (HIV-1) plus-strand transfer. These events include synthesis of plus-strand strong-stop DNA [(+) SSDNA] from a minus-strand DNA donor template covalently attached to human tRNA3Lys, tRNA primer removal,
- Simian immunodeficiency virus disease course is predicted by the extent of virus replication during primary infection.
- J Virol. 1999 Jun;73(6):4829-39. Unique Identifier : AIDSLINE MED/99252174
- Staprans SI; Dailey PJ; Rosenthal A; Horton C; Grant RM; Lerche N; Feinberg MB; Department of Medicine-AIDS Program, University of California,; San Francisco, San Francisco, California 94110, USA.
- To elucidate the relationship between early viral infection events and immunodeficiency virus disease progression, quantitative-competitive and branched-DNA methods of simian immunodeficiency virus (SIV) RNA quantitation were cross-validated and used to measure viremia following infection of rhesus macaques with the p
- The 5' RNA terminus of spleen necrosis virus contains a novel posttranscriptional control element that facilitates human immunodeficiency virus Rev/RRE-independent Gag production.
- J Virol. 1999 Jun;73(6):4847-55. Unique Identifier : AIDSLINE MED/99252176
- Butsch M; Hull S; Wang Y; Roberts TM; Boris-Lawrie K; Department of Veterinary Biosciences, Center for Retrovirus; Research, Comprehensive Cancer Center, The Ohio State University,; Columbus, Ohio 43210-1093, USA.
- Previous work has shown that spleen necrosis virus (SNV) long terminal repeats (LTRs) are associated with Rex/Rex-responsive element-independent expression of bovine leukemia virus RNA and supports the hypothesis that SNV RNA contains a cis-acting element that interacts with cellular Rex-like proteins. To test this hy
- Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone.
- J Virol. 1999 Jun;73(6):4856-65. Unique Identifier : AIDSLINE MED/99252177
- Robek MD; Ratner L; Departments of Medicine, Pathology, and Molecular Microbiology,; Washington University School of Medicine, St. Louis, Missouri; 63110, USA.
- The human T-cell leukemia virus type 1 (HTLV-1) transcriptional trans-activator Tax has been demonstrated to have transforming activity in multiple cell culture and transgenic-mouse models. In addition to activating transcription from the viral long terminal repeat (LTR) through the cyclic AMP response element binding
- Definition of the stage of host cell genetic restriction of replication of human immunodeficiency virus type 1 in monocytes and monocyte-derived macrophages by using twins.
- J Virol. 1999 Jun;73(6):4866-81. Unique Identifier : AIDSLINE MED/99252178
- Naif HM; Li S; Alali M; Chang J; Mayne C; Sullivan J; Cunningham AL; Centre for Virus Research, Westmead Institutes of Health; Research, Australian National Centre for HIV Virology Research,; Westmead Hospital, Westmead, New South Wales 2145, Australia.; hassanm@westmed.wh.usyd.edu.au
- Using identical (ID) twins, we have previously demonstrated that host cell genes exert a significant impact on productive human immunodeficiency virus (HIV) infection of monocytes and macrophages (J. Chang et al., J. Virol. 70:7792-7803, 1996). Therefore, the stage in the replication cycle at which these host genetic
- Highly attenuated vaccine strains of simian immunodeficiency virus protect against vaginal challenge: inverse relationship of degree of protection with level of attenuation.
- J Virol. 1999 Jun;73(6):4952-61. Unique Identifier : AIDSLINE MED/99252187
- Johnson RP; Lifson JD; Czajak SC; Cole KS; Manson KH; Glickman R; Yang J; Montefiori DC; Montelaro R; Wyand MS; Desrosiers RC; New England Regional Primate Research Center, Harvard Medical; School, Southborough, Massachusetts 01772-9102, USA.
- Three different deletion mutants of simian immunodeficiency virus (SIV) that vary in their levels of attenuation were tested for the ability to protect against mucosal challenge with pathogenic SIV. Four female rhesus monkeys were vaccinated by intravenous inoculation with SIVmac239Delta3, four with SIVmac239Delta3X,
- Anti-Rex aptamers as mimics of the Rex-binding element.
- J Virol. 1999 Jun;73(6):4962-71. Unique Identifier : AIDSLINE MED/99252188
- Baskerville S; Zapp M; Ellington AD; Department of Biology, Indiana University at Bloomington,; Bloomington, Indiana, USA.
- RNA molecules that bind tightly and specifically to a Rex fusion protein have been isolated from a conformationally constrained pool of random sequence RNAs. The anti-Rex aptamers effectively mimic several features of the wild-type Rex-binding element (XBE). The highest-affinity aptamers effectively compete with the w
- Minimum requirements for efficient transduction of dividing and nondividing cells by feline immunodeficiency virus vectors.
- J Virol. 1999 Jun;73(6):4991-5000. Unique Identifier : AIDSLINE MED/99252191
- Johnston JC; Gasmi M; Lim LE; Elder JH; Yee JK; Jolly DJ; Campbell KP; Davidson BL; Sauter SL; Center for Gene Therapy, Chiron Technologies, San Diego,; California 92121, USA.
- The development of gene delivery vectors based on feline immunodeficiency virus (FIV) is an attractive alternative to vectors based on primate sources for the delivery of genes into humans. To investigate the requirements for efficient transduction of dividing and nondividing cells by vector particles based on FIV, a
- Polarized human immunodeficiency virus budding in lymphocytes involves a tyrosine-based signal and favors cell-to-cell viral transmission.
- J Virol. 1999 Jun;73(6):5010-7. Unique Identifier : AIDSLINE MED/99252193
- Deschambeault J; Lalonde JP; Cervantes-Acosta G; Lodge R; Cohen EA; Lemay G; Departement de Microbiologie et Immunologie, Universite de; Montreal, Montreal, Quebec H3C 3J7, Canada.
- Maturation and release of human immunodeficiency virus type 1 (HIV-1) is targeted at the pseudopod of infected mononuclear cells. However, the intracellular mechanism or targeting signals leading to this polarized viral maturation are yet to be identified. We have recently demonstrated the presence of a functional YXX
- Oligomerization within virions and subcellular localization of human immunodeficiency virus type 1 integrase.
- J Virol. 1999 Jun;73(6):5079-88. Unique Identifier : AIDSLINE MED/99252201
- Petit C; Schwartz O; Mammano F; Unite d'Oncologie Virale, Institut Pasteur, Paris, France.
- Previous biochemical and genetic evidence indicated that the functional form of retroviral integrase protein (IN) is a multimer. A direct demonstration of IN oligomerization during the infectious cycle was, however, missing, due to the absence of a sensitive detection method. We describe here the generation of infecti
- Characterization of monoclonal antibodies raised against the latent nuclear antigen of human herpesvirus 8.
- J Virol. 1999 Jun;73(6):5149-55. Unique Identifier : AIDSLINE MED/99252209
- Kellam P; Bourboulia D; Dupin N; Shotton C; Fisher C; Talbot S; Boshoff C; Weiss RA; Institute of Cancer Research, Chester Beatty Laboratories, London; SW3 6JB, United Kingdom. p.Kellam@ucl.ac.uk
- Human herpesvirus 8 (HHV-8; also designated Kaposi s sarcoma-associated herpesvirus) is the likely etiological agent of Kaposi s sarcoma (KS). HHV-8 encodes a latent nuclear antigen (LNA) which is the product of the viral gene orf 73. LNA is recognized by most infected patient sera and is the basis of current immunofl
- Potent inhibition of human immunodeficiency virus type 1 (HIV-1) gene expression and virus production by an HIV-2 tat activation-response RNA decoy.
- J Virol. 1999 Jun;73(6):5191-5. Unique Identifier : AIDSLINE MED/99252217
- Browning CM; Cagnon L; Good PD; Rossi J; Engelke DR; Markovitz DM; Department of Microbiology and Immunology, University of; Michigan, Ann Arbor, Michigan 48109, USA.
- Tat activation-response region (TAR) decoys have been developed for use in gene therapy for people infected with human immunodeficiency virus type 1 (HIV-1). When a TAR RNA decoy is overexpressed, it will bind Tat, thus leaving less of this crucial protein to bind to and activate the natural transcriptional promoter o
- Human immunodeficiency virus type 2 produces a defect in CD3-gamma gene transcripts similar to that observed for human immunodeficiency virus type 1.
- J Virol. 1999 Jun;73(6):5207-13. Unique Identifier : AIDSLINE MED/99252220
- Segura I; Delmelle-Wibaut C; Janssens M; Cleuter Y; van den Broeke A; Kettmann R; Willard-Gallo KE; International Institute of Cellular and Molecular Pathology,; B1200 Brussels, Belgium.
- T cells are central players in the immune response to infectious disease, with the specificity of their responses controlled by the T-cell receptor (TCR)/CD3 complex on the cell surface. Impairment of TCR/CD3-directed CD4(+) T-cell immune responses is frequently observed in individuals infected with human immunodefici
- Primary virus envelope cross-reactivity of the broadening neutralizing antibody response during early chronic human immunodeficiency virus type 1 infection.
- J Virol. 1999 Jun;73(6):5225-30. Unique Identifier : AIDSLINE MED/99252223
- Zhang PF; Chen X; Fu DW; Margolick JB; Quinnan GV Jr; Department of Preventive Medicine and Biometrics, Division of; Tropical Public Health, Uniformed Services University of the; Health Sciences, Bethesda, Maryland 20814, USA.
- To test the hypothesis that changing neutralizing antibody responses against human immunodeficiency virus type 1 (HIV-1) during chronic infection were a response to emergence of neutralization escape mutants, we cloned expressed and characterized envelope clones from patients in the Multicenter AIDS Cohort Study (MACS
- An orphan G protein-coupled receptor, GPR1, acts as a coreceptor to allow replication of human immunodeficiency virus types 1 and 2 in brain-derived cells.
- J Virol. 1999 Jun;73(6):5231-9. Unique Identifier : AIDSLINE MED/99252224
- Shimizu N; Soda Y; Kanbe K; Liu HY; Jinno A; Kitamura T; Hoshino H; Department of Hygiene and Virology, Gunma University School of; Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511,; Minato-ku, Tokyo 105-0071, Japan.
- Twelve G protein-coupled receptors, including chemokine receptors, act as coreceptors and determinants for the cell tropisms of human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus (SIV). We isolated HIV-1 variants from T-cell-line (T)- and macrophage (M)-tropic (i.e., dualtropic) (R5-
- Human erythrocyte glycosphingolipids as alternative cofactors for human immunodeficiency virus type 1 (HIV-1) entry: evidence for CD4-induced interactions between HIV-1 gp120 and reconstituted membrane microdomains of glycosphingolipids (Gb3 and GM3).
- J Virol. 1999 Jun;73(6):5244-8. Unique Identifier : AIDSLINE MED/99252226
- Hammache D; Yahi N; Maresca M; Pieroni G; Fantini J; Laboratoire de Biochimie et Biologie de la Nutrition, ESA-CNRS; 6033, Faculte des Sciences de St Jerome, 13397 Marseille Cedex; 20, France.
- Glycosphingolipids from human erythrocytes mediate CD4-dependent fusion with cells expressing human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins. To identify the glycosphingolipid(s) which participates in the fusion process, we have analyzed the interaction of HIV-1 gp120 (X4 and R5X4 isolates) with re
- Iron and anemia of chronic disease.
- Kidney Int Suppl. 1999 Mar;69:S12-7. Unique Identifier : AIDSLINE MED/99181772
- Weiss G; Department of Internal Medicine, University Hospital, Innsbruck,; Austria. guenter.weiss@uibk.ac.at
- Anemia of chronic disease (ACD) is the most frequent anemia found in hospitalized patients, often occurring in subjects suffering from chronic inflammatory disorders. The underlying diversion of iron traffic leads to a withdrawal of the metal from the sites of erythropoiesis and the circulation to the storage compartm
- The disappearing CD4(+)T cells in HIV infection: a case of over-stimulation?
- J Theor Biol. 1999 Apr 21;197(4):507-16. Unique Identifier : AIDSLINE MED/99214277
- Wick D; Fred Hutchinson Cancer Research Center, MP-900, 1124 Columbia; Street, Seattle, WA 98105-2092, USA. wick@hivnet.fhcrc.org
- Infection with the human immunodeficiency virus (HIV) causes a gradual decline in essential immune-system cells called CD4(+) helper T cells. These cells are also principal viral targets, but, paradoxically, direct cell-killing does not explain their disappearance. HIV also induces a chronic and increasing state of i
- Zuma defends decision to make AIDS a notifiable disease [news]
- Lancet. 1999 May 8;353(9164):1599. Unique Identifier : AIDSLINE MED/99265439
- Baleta A
- Thailand attacks AIDS with two-pronged approach [news]
- Lancet. 1999 May 8;353(9164):1600. Unique Identifier : AIDSLINE MED/99265440
- Berman J
- Audio-computer interviewing to measure risk behaviour for HIV among injecting drug users: a quasi-randomised trial.
- Lancet. 1999 May 15;353(9165):1657-61. Unique Identifier : AIDSLINE MED/99266816
- Des Jarlais DC; Paone D; Milliken J; Turner CF; Miller H; Gribble J; Shi Q; Hagan H; Friedman SR; Beth Israel Medical Center, Chemical Dependency Institute, New; York, NY 10003, USA.
- BACKGROUND: We aimed to assess audio-computer-assisted self-interviewing (audio-CASI) as a method of reducing under-reporting of HIV risk behaviour among injecting drug users. METHODS: Injecting drug users were interviewed at syringe-exchange programmes in four US cities. Potential respondents were randomly selected f
- A sore anus for 6 months.
- Lancet. 1999 May 15;353(9165):1672. Unique Identifier : AIDSLINE MED/99266819
- Winceslaus SJ; Schofield J; Department of Genitourniary Medicine, Kent and Sussex Hospital,; Kent, UK.
- Latent dysbetalipoproteinaemia precipitated by HIV-protease inhibitors [letter]
- Lancet. 1999 May 15;353(9165):1678. Unique Identifier : AIDSLINE MED/99266826
- Lister RK; Youle M; Nair DR; Winder AF; Rustin MH
- HIV-treatment guidelines [news]
- Lancet. 1999 May 15;353(9165):1682. Unique Identifier : AIDSLINE MED/99266831
- When pharmaceutical wrangles cast a wide net [news]
- Lancet. 1999 May 15;353(9165):1685. Unique Identifier : AIDSLINE MED/99266834
- Baleta A
- AIDS campaigner on trial for testing vaccine on people [news]
- Lancet. 1999 May 15;353(9165):1686. Unique Identifier : AIDSLINE MED/99266835
- Kumar S
- Therapeutic vaccines for preventing AIDS: their use with HAART [comment]
- Lancet. 1999 May 22;353(9166):1723-4. Unique Identifier : AIDSLINE MED/99275734
- Hoff R; McNamara J; Vaccine and Prevention Research Program, and Therapeutic Research; Program, Division of AIDS, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA.
- Therapeutic immunisation with recombinant gp160 in HIV-1 infection: a randomised double-blind placebo-controlled trial. Nordic VAC-04 Study Group [see comments]
- Lancet. 1999 May 22;353(9166):1735-42. Unique Identifier : AIDSLINE MED/99275741
- Sandstrom E; Wahren B; Department of Dermatovenereology, Soder Hospital, Stockholm,; Sweden. eric.sandstrom@venh.sos.sll.se
- BACKGROUND: The immune system s ability to scavenge and destroy detrimental HIV-1 products has an important effect on virion production and the course of infection. In earlier trials of therapeutic immunisation with envelope protein recombinant gp160 (rgp160) we observed a transient positive effect on CD4-lymphocyte c
- Sexual dysfunction with protease inhibitors [letter]
- Lancet. 1999 May 22;353(9166):1802. Unique Identifier : AIDSLINE MED/99275780
- Colebunders R; Smets E; Verdonck K; Dreezen C
- Say no to boycott of AIDS conference [letter]
- Nature. 1999 Apr 15;398(6728):555. Unique Identifier : AIDSLINE MED/99231485
- Wainberg MA
- [Therapeutic options for HIV infection should lead to increased utilization of HIV tests]
- Ned Tijdschr Geneeskd. 1999 Mar 20;143(12):598-9. Unique Identifier : AIDSLINE MED/99254586
- Coutinho RA; Hoogkamp-Korstanje JA; Danner SA; Academisch Medisch Centrum, afd. Humane Retrovirologie,; Amsterdam.
- Owing to the recent advances in drug therapy for HIV infected patients, HIV infection is no longer an untreatable condition. The Health Council of the Netherlands therefore considers the advantages of knowing a person s HIV status to outweigh the disadvantages, especially for
- [Memisa and home nursing of AIDS patients in Zambia (letter; comment)]
- Ned Tijdschr Geneeskd. 1999 Mar 27;143(13):701-2. Unique Identifier : AIDSLINE MED/99254615
- Zaaijer LN
- Renal tolerance of indinavir in HIV-positive patients [letter]
- Nephron. 1999;82(1):72. Unique Identifier : AIDSLINE MED/99242705
- Guery B; Tubiana R; Martinez F; Jacquiaud C; Bochet M; Katlama C; Deray G
- Cerebrospinal fluid tau protein is not elevated in HIV-associated neurologic disease in humans. HIV Neurobehavioral Research Center Group (HNRC).
- Neurosci Lett. 1998 Sep 18;254(1):1-4. Unique Identifier : AIDSLINE MED/98451357
- Ellis RJ; Seubert P; Motter R; Galasko D; Deutsch R; Heaton RK; Heyes MP; McCutchan JA; Atkinson JH; Grant I; Department of Neurosciences, University of California, San Diego,; USA. roellis@ucsd.edu
- We measured the concentrations of the neuron-specific protein, tau, in the cerebrospinal fluid (CSF) of 32 neurologically characterized HIV-infected (HIVpos) subjects and nine matched seronegative (HIVneg) controls using a sensitive ELISA assay. Of 32 HIVpos subjects, nine had HIV-associated neurocognitive disorders,
- [Therapeutic problems with HIV-infected tuberculous spondylitis patients in the South African Republic]
- Orv Hetil. 1999 Mar 28;140(13):711-3. Unique Identifier : AIDSLINE MED/99278935
- Risko Z; Tambo Memorial Hospital, Boksburg, Del-afrikai Koztarsasag.
- We can only hope, that the dual epidemic of tuberculosis and HIV disease is not going to affect the population of Europe and Hungary so badly and unexpectedly as it happened in sub-Saharan Africa. The spinal tuberculosis with or wit
- Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non-obese diabetic mice.
- Parasite Immunol. 1999 Apr;21(4):169-76. Unique Identifier : AIDSLINE MED/99255837
- Cooke A; Tonks P; Jones FM; O'Shea H; Hutchings P; Fulford AJ; Dunne DW; Division of Immunology, Department of Pathology, University of; Cambridge, UK.
- The spontaneous development of insulin dependent diabetes mellitus in non-obese diabetic (NOD) mice has been shown to be mediated by a Th1 response against beta cell antigens. It is known that in murine models of Schistosoma mansoni infection, egg production is associated with a switch from a Th1 to Th2 response. This
- Experimental Leishmania major infection in mice: role of IL-10.
- Parasite Immunol. 1999 Apr;21(4):211-8. Unique Identifier : AIDSLINE MED/99255841
- Chatelain R; Mauze S; Coffman RL; Laboratory of Immunodermatology, Department of Dermatology,; Ludwig-Maximilians-University, Frauenlobstrasse 9-11, 80538,; Munich, Germany.
- L. major infection of mice induces polarized Th1 and Th2 responses that are correlated with healing of the infection (Th1) or a fatal disease (Th2). The Th subset specific cytokines, IFNgamma and IL-4, themselves were shown to be important factors for the differentiation into the Th1 and Th2 pathways during infection.
- Design, characterization and testing of tRNA3Lys-based hammerhead ribozymes.
- Nucleic Acids Res. 1999 Apr 1;27(7):1698-708. Unique Identifier : AIDSLINE MED/99177335
- Medina MF; Joshi S; Department of Medical Genetics and Microbiology, Faculty of; Medicine, University of Toronto, 150 College Street #212,; Toronto, Ontario M5S 3E2, Canada.
- A hammerhead ribozyme targeted against the HIV-1 env coding region was expressed as part of the anticodon loop of human tRNA3Lys without sacrificing tRNA stability or ribozyme catalytic activity. These tRNA-ribozymes were isolated from a library which was designed to contain linkers (sequences connecting the ribozyme
- Peritoneal port offers new approach to HIV therapy.
- Nurs Times. 1999 Mar 31-Apr 6;95(13):48-9. Unique Identifier : AIDSLINE MED/99286632
- Waterworth C; Chelsea and Westminster Hospital, London.
- This article gives a brief overview of HIV care and discusses the nursing aspects of implementing a multicentre research project that offers an experimental intraperitoneal approach to anti-HIV therapy.
- Positive attitudes required.
- Nurs Times. 1999 Apr 14-20;95(15):22. Unique Identifier : AIDSLINE MED/99286647
- Sommerville F; Midwifery Services, Brighton Health Care NHS Trust.
- Methadone withdrawal when starting an antiretroviral regimen including nevirapine.
- Pharmacotherapy. 1999 Apr;19(4):471-2. Unique Identifier : AIDSLINE MED/99227003
- Heelon MW; Meade LB; Department of Pharmacy, Baystate Medical Center, Springfield,; Massachusetts, USA.
- Antiretrovirals from three drug classes, nucleoside analogs, nonnucleoside analogs, and protease inhibitors , can be combined to achieve viral suppression. The nonnucleoside analog nevirapine is an i
- A mimic of HIV-1 nucleocapsid protein impairs reverse transcription and displays antiviral activity.
- Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):4886-91. Unique Identifier : AIDSLINE MED/99238452
- Druillennec S; Dong CZ; Escaich S; Gresh N; Bousseau A; Roques BP; Fournie-Zaluski MC; Departement de Pharmacochimie Moleculaire et Structurale, U 266; Institut National de la Sante et de la Recherche Medicale,; Unite Mixte de Recherche, France.
- Combined inhibition of HIV-1 reverse transcriptase and protease has significantly improved the treatment of AIDS. Nevertheless, resistance to these drugs occurs rapidly because of viral mutations, emphasizing the importance of identifying novel retroviral targets to develop new drug combinations. The critical role pla
- Mitochondrial sequences show diverse evolutionary histories of African hominoids.
- Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5077-82. Unique Identifier : AIDSLINE +
- Gagneux P; Wills C; Gerloff U; Tautz D; Morin PA; Boesch C; Fruth B; Hohmann G; Ryder OA; Woodruff DS; Department of Biology and Center for Molecular Genetics,; University of California at San Diego, La Jolla, CA 92093-0116,; USA. gagneux@biomail.ucsd.edu
- Phylogenetic trees for the four extant species of African hominoids are presented, based on mtDNA control region-1 sequences from 1,158 unique haplotypes. We include 83 new haplotypes of western chimpanzees and bonobos. Phylogenetic analysis of this enlarged database, which takes intraspecific geographic variability i
- CD4(+) T cell-mediated control of a gamma-herpesvirus in B cell-deficient mice is mediated by IFN-gamma.
- Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5135-40. Unique Identifier : AIDSLINE MED/99238495
- Christensen JP; Cardin RD; Branum KC; Doherty PC; St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
- The lack of B cells and antibody does not prevent mice from dealing effectively with a pathogenic gamma-herpesvirus. Both CD4(+) and CD8(+) T cells contribute to the control of virus replication in the respiratory tract, with the depletion of either lymphocyte subset leading to increased titers in the lung. However, t
- Reversibility of the pathological changes in the follicular dendritic cell network with treatment of HIV-1 infection.
- Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5169-72. Unique Identifier : AIDSLINE MED/99238501
- Zhang ZQ; Schuler T; Cavert W; Notermans DW; Gebhard K; Henry K; Havlir DV; Gunthard HF; Wong JK; Little S; Feinberg MB; Polis MA; Schrager LK; Schacker TW; Richman DD; Corey L; Danner SA; Haase AT; Department of Microbiology, University of Minnesota Medical; School, Minneapolis, MN 55455, USA.
- Over the course of HIV-1 infection, the lymphoid follicles where the humoral immune response is generated initially increase in size and number and then progressively involute. In advanced disease, the network of the processes of follicular dendritic cells (FDCs) that serve as antigen repositories and anatomical subst
- Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages.
- Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5215-20. Unique Identifier : AIDSLINE MED/99238510
- Lee B; Sharron M; Montaner LJ; Weissman D; Doms RW; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia, PA 19104, USA.
- CCR5 and CXCR4 are the major HIV-1 coreceptors for R5 and X4 HIV-1 strains, respectively, and a threshold number of CD4 and chemokine receptor molecules is required to support virus infection. Therefore, we used a quantitative fluorescence-activated cell sorting assay to determine the number of CD4, CCR5, and CXCR4 an
- Role of the immune system in mediating the antitumor effect of benzophenothiazine photodynamic therapy.
- Photochem Photobiol. 1999 May;69(5):575-81. Unique Identifier : AIDSLINE MED/99266306
- Hendrzak-Henion JA; Knisely TL; Cincotta L; Cincotta E; Cincotta AH; Ergo Science Corporation, Charlestown, MA 02129, USA.
- The role of the host immune system in contributing to tumor regression following benzophenothiazine photodynamic therapy (PDT) was examined. Photodynamic therapy with 2-iodo-5-ethylamino-9-diethylaminobenzo[a]-phenothiazinium chloride (2I-EtNBS) eradicated EMT-6 mammary fibrosarcomas in 75-100% of treated mice. In con
- [Unusual case of sterno-clavicular septic arthritis in AIDS: ultrasonography, computerized tomography, and magnetic resonance findings]
- Radiol Med (Torino). 1999 Jan-Feb;97(1-2):86-8. Unique Identifier : AIDSLINE MED/99252664
- Nicastro N; Finazzo M; Gallo C; Iovane A; Midiri M; Istituto di Radiologia Pietro Cignolini, Universita degli Studi,; Palermo.
- [Nevirapine (Viramune): a new HIV inhibitor]
- Rev Med Brux. 1999 Apr;20(2):95-9. Unique Identifier : AIDSLINE MED/99267585
- De Wit S; Sternon J; Clumeck N; Service des Maladies Infectieuses, C.H.U. Saint-Pierre.
- Nevirapine is the first member of a new therapeutic class (NNRTI: non nucleoside inhibitors of the reverse transcriptase) in the treatment against human immunodeficiency virus (HIV). In association with two other antiretroviral products, it reduces significantly the viral load and increases the CD4-cells-count, especi
- Modulation of T cell function by alpha-fetoprotein: An in vivo study on porcine thyroid peroxidase-induced experimental autoimmune thyroiditis in transgenic mice producing human alpha-fetoprotein.
- Tumour Biol. 1999 May-Jun;20(3):162-71. Unique Identifier : AIDSLINE MED/99234305
- Matsuura E; Kang Y; Kitakawa H; Ogata A; Kotani T; Ohtaki S; Nishi S; Department of Biochemistry, Hokkaido University School of; Medicine, Sapporo, Japan.
- Experimental autoimmune thyroiditis was induced in transgenic mice (TG-3) producing human alpha-fetoprotein (AFP) and in control mice by immunization of porcine thyroid peroxidase (TPO). Development of thyroiditis accompanied with mononuclear cell infiltration was observed in 6 out of 8 treated control mice. In contra
- [Kaposi's disease]
- Rev Prat. 1999 Apr 15;49(8):843-7. Unique Identifier : AIDSLINE MED/99269491
- Lebbe C; Policlinique de dermatologie Hopital Saint-Louis, Paris.
- The 4 clinical settings of Kaposi s sarcoma, namely classic, endemic, epidemic and post-transplant Kaposi s sarcoma share the same histological features and are all associated to a new herpesvirus, human herpesvirus 8. However, they differ according to their prognosis and therapeutic considerations.
- Serum levels of Fas/Apo-1 and Bcl-2 in children with HIV-1 infection.
- Scand J Infect Dis. 1998;30(6):565-8. Unique Identifier : AIDSLINE MED/99239889
- Torre D; Zeroli C; Speranza F; Martegani R; Fiori G; Airoldi M; Division of Infectious Diseases, Regional Hospital and Foundation; Macchi, Varese, Italy.
- Apoptosis of CD4-positive T cells is considered to be involved in depletion of CD4-positive T cells in adult patients with HIV-1 infection. In this report we evaluated serum levels of soluble Fas/Apo-1 and circulating bcl-2 protein (an antiapoptotic molecule) in HIV-1-infected children, and 30 HIV-1 seronegative child
- Rapid loss of specific antibodies after pneumococcal vaccination in patients with human immunodeficiency virus-1 infection.
- Scand J Infect Dis. 1998;30(6):597-601. Unique Identifier : AIDSLINE MED/99239895
- Nielsen H; Kvinesdal B; Benfield TL; Lundgren JD; Konradsen HB; Department of Infectious Diseases, Rigshospitalet, Hvidovre,; Denmark.
- Pneumococcal infections are frequently observed in patients with human immunodeficiency virus (HIV) infection and active immunization has been recommended as prophylaxis in this patient group. We studied 103 out-patients with asymptomatic or mildly symptomatic HIV infection with respect to specific IgG and IgG2 pneumo
- Continued therapy with HIV-1 protease inhibitors, despite previous hypersensitivity reactions, through coadministration of prednisone.
- Scand J Infect Dis. 1998;30(6):612-3. Unique Identifier : AIDSLINE MED/99239899
- Prins JM; Schellekens PT; Reiss P; Department of Internal Medicine, Academic Medical Center,; University of Amsterdam, The Netherlands. j.m.prins@amc.uva.nl
- We describe an HIV-1 positive patient who developed severe hypersensitivity reactions during treatment with each of the three currently available protease inhibitors . Addition of prednisone enabled continued use of saquinavir, one of these protease inhibitors, there
- Complete histological regression of Kaposi's sarcoma following treatment with protease inhibitors despite persistence of HHV-8 in lesions.
- Scand J Infect Dis. 1998;30(6):613-5. Unique Identifier : AIDSLINE MED/99239900
- Benfield TL; Kirk O; Elbrond B; Pedersen C; Department of Infectious Diseases, Hvidovre Hospital, Denmark.
- There is no current curative treatment for HIV-related Kaposi s sarcoma. The identification of human herpesvirus-8 as a possible aetiological agent suggests potential efficacy of anti-viral agents. We report here on the complete histological remission of Kaposi s sarcoma following treatment with
- HIV combination therapy: immune restitution causing cryptococcal lymphadenitis dramatically improved by anti-inflammatory therapy.
- Scand J Infect Dis. 1998;30(6):615-6. Unique Identifier : AIDSLINE MED/99239901
- Blanche P; Gombert B; Ginsburg C; Passeron A; Stubei I; Rigolet A; Salmon D; Sicard D; Service de Medecine Interne 2, Hopital Cochin, Universite; Rene Descartes, Paris, France.
- Two patients with AIDS developed microscopically verified focal cryptococcal lymphadenitis while treated with highly active anti-retroviral therapy for 8 and 15 months. Both were treated with fluconazole as a secondary prophylaxis for prior cryptococcal meningitis. Cryptococcus neoformans did not grow. Amphotericin wa
- Stevens-Johnson syndrome caused by indinavir.
- Scand J Infect Dis. 1998;30(6):634-5. Unique Identifier : AIDSLINE MED/99239911
- Teira R; Zubero Z; Munoz J; Baraia-Etxaburu J; Santamaria JM; Seccion de Enfermedades Infecciosas, Hospital de Basurto,; Bilbao, Spain.
- A case is presented of an HIV-infected man who developed Stevens-Johnson syndrome shortly after the initiation of treatment with indinavir . This is the first case ever reported of this adverse drug reaction occurring with an HIV protease inhibitor.
- AIDS now world's fourth biggest killer [news]
- Science. 1999 May 14;284(5417):1101. Unique Identifier : AIDSLINE MED/99288675
- Balter M
- HIV. French-led therapy fund kicks off in Africa [news]
- Science. 1999 May 14;284(5417):1101. Unique Identifier : AIDSLINE MED/99288674
- Balter M
- Inactivation of misselected CD8 T cells by CD8 gene methylation and cell death.
- Science. 1999 May 14;284(5417):1187-91. Unique Identifier : AIDSLINE MED/99263143
- Pestano GA; Zhou Y; Trimble LA; Daley J; Weber GF; Cantor H; Department of Cancer Immunology and AIDS, Dana Farber Cancer; Institute, Harvard Medical School, 44 Binney Street, Boston MA; 02115, USA.
- Misselected CD8 cells that express T cell receptors (TCRs) that do not recognize class I major histocompatibility complex (MHC) protein can emerge from thymic selection. A postthymic quality control mechanism that purges these cells from the repertoire is defined here. The failure of mature CD8 cells to simultaneously
- Lower genital tract infections among HIV-infected and high-risk uninfected women: findings of the Women's Interagency HIV Study (WIHS).
- Sex Transm Dis. 1999 Mar;26(3):143-51. Unique Identifier : AIDSLINE MED/99198870
- Greenblatt RM; Bacchetti P; Barkan S; Augenbraun M; Silver S; Delapenha R; Garcia P; Mathur U; Miotti P; Burns D; Department of Medicine, University of California, San Francisco,; 94143, USA.
- BACKGROUND AND OBJECTIVES: Few comparisons of factors associated with sexually transmitted diseases (STDs) and HIV are available for representative samples of American women. GOAL OF THE STUDY: To compare factors associated with STDs in a large sample of women infected with HIV and women not infected with HIV. STUDY D
- Forgetting as a cause of incomplete reporting of sexual and drug injection partners.
- Sex Transm Dis. 1999 Mar;26(3):166-76. Unique Identifier : AIDSLINE MED/99198874
- Brewer DD; Garrett SB; Kulasingam S; Alcohol and Drug Abuse Institute, University of Washington,; Seattle 98105, USA. ddbrewer@u.washington.edu
- BACKGROUND AND OBJECTIVES: Partner notification and social network studies of infectious disease often involve interviewing people to elicit their sexual and/or drug injection partners. Incomplete reporting of partners in these contexts would significantly hamper efforts to understand and control the spread of sexuall
- A double-'blind' placebo-controlled study of nitazoxanide in the treatment of cryptosporidial diarrhoea in AIDS patients in Mexico.
- Trans R Soc Trop Med Hyg. 1998 Nov-Dec;92(6):663-6. Unique Identifier : AIDSLINE MED/99257966
- Rossignol JF; Hidalgo H; Feregrino M; Higuera F; Gomez WH; Romero JL; Padierna J; Geyne A; Ayers MS; Romark Institute for Medical Research, Tampa, Florida, USA.; jrossignol@aol.com
- Sixty-six patients with human immunodeficiency virus infection and diarrhoea caused by Cryptosporidium parvum were enrolled in a double- blind placebo-controlled study to evaluate the safety and efficacy of nitazoxanide in the treatment of cryptosporidiosis related to the acquired immune deficiency syndrome. Patients
- Foscarnet-induced crystalline glomerulonephritis with nephrotic syndrome and acute renal failure after kidney transplantation.
- Transplantation. 1999 May 27;67(10):1376-8. Unique Identifier : AIDSLINE MED/99287340
- Zanetta G; Maurice-Estepa L; Mousson C; Justrabo E; Daudon M; Rifle G; Tanter Y; Department of Nephrology-Intensive Care, Centre Hospitalier; Universitaire, Dijon, France.
- Foscarnet nephrotoxicity has been reported to be associated with acute tubulointerstitial nephritis. Crystals in glomerular capillary lumens have also been observed in patients with acquired immunodeficiency syndrome who were treated with foscarnet for cytomegalovirus disease. We d
- Human herpes virus-8 and other risk factors for Kaposi's sarcoma in kidney transplant recipients. Groupe Cooperatif de Transplantation d' Ile de France (GCIF).
- Transplantation. 1999 May 15;67(9):1236-42. Unique Identifier : AIDSLINE MED/99271743
- Farge D; Lebbe C; Marjanovic Z; Tuppin P; Mouquet C; Peraldi MN; Lang P; Hiesse C; Antoine C; Legendre C; Bedrossian J; Gagnadoux MF; Loirat C; Pellet C; Sheldon J; Golmard JL; Agbalika F; Schulz TF; Hopital Saint-Louis, Paris, France. d.farge@chu-stlouis-fr
- BACKGROUND: The exact reasons for the high incidence of Kaposi s sarcoma (KS) after kidney transplantation are still unknown. Immunosuppression is classically considered as the main risk factor, but the relative risk contributed by the patient s geographic origin and by human herpes virus (HHV)-8 infection still has t
- A direct method for the calculation of alloreactive CD4+ T cell precursor frequency.
- Transplantation. 1999 May 15;67(9):1281-4. Unique Identifier : AIDSLINE MED/99271751
- Noorchashm H; Lieu YK; Rostami SY; Song HK; Greeley SA; Bazel S; Barker CF; Naji A; Department of Surgery, University of Pennsylvania Medical Center,; Philadelphia 19104, USA.
- BACKGROUND: Direct measurement of the precursor frequency of alloreactive CD4+ T cells has been impossible due to the lack of a specific means of determining the absolute number of daughter cells generated with each division in a repertoire of stimulated T cells. METHODS: Responder lymphocytes were fluorescently label
- Successful use of lamivudine for severe acute hepatitis B virus infection in a cardiac transplant recipient [letter]
- Transplantation. 1999 May 15;67(9):1288-9. Unique Identifier : AIDSLINE MED/99271753
- Dulai G; Higa L; Kobashigawa J; Martin P
- A rheumatic view.
- Trans Med Soc Lond. 1996-97;113:1-5. Unique Identifier : AIDSLINE MED/99257929
- Keat A
- Drug injecting and the spread of AIDS.
- Trans Med Soc Lond. 1996-97;113:69-76. Unique Identifier : AIDSLINE MED/99257940
- Stimson G
- Potency of an experimental DNA vaccine against Aujeszky's disease in pigs.
- Vet Microbiol. 1999 Mar 31;66(1):1-13. Unique Identifier : AIDSLINE MED/99237829
- Gerdts V; Jons A; Mettenleiter TC; Institute of Molecular and Cellular Virology,; Friedrich-Loeffler-Institutes, Federal Research Centre for Virus; Diseases of Animals, Insel Riems, Germany.
- Intradermal vaccination with plasmid DNA encoding envelope glycoprotein C (gC) of pseudorabies virus (PrV) conferred protection of pigs against Aujeszky s disease when challenged with strain 75V19, but proved to be inadequate for protection against the highly virulent strain NIA-3. To improve the performance of the DN
- Mycobacteria other than tuberculosis with an emphasis on Mycobacterium xenopi in clinical specimens from AIDS patients at the University Hospital of Vienna from 1989 to 1996.
- Wien Klin Wochenschr. 1999 Jan 29;111(2):56-8. Unique Identifier : AIDSLINE MED/99180963
- Stauffer F; Bankier AA; Strasser G; Kreuzer S; Lahounik E; Rieger A; Bundesstaatliche bakteriologisch-serologische; Untersuchungsanstalt Wien, Austria. bbsuawien@aon.at
- This study was carried out to provide an overview of the frequency of various mycobacterial species isolated from AIDS patients at the University Hospital of Vienna from 1989 to 1996. Mycobacterium xenopi was found to be the second most common nontuberculous mycobacterial species (92 specimens from 30 patients) and wa
- Analysis of the ability of five adjuvants to enhance immune responses to a chimeric plant virus displaying an HIV-1 peptide.
- Vaccine. 1999 Mar 17;17(11-12):1359-68. Unique Identifier : AIDSLINE MED/99210146
- McInerney TL; Brennan FR; Jones TD; Dimmock NJ; Department of Biological Sciences, University of Warwick,; Coventry, UK.
- The ability of five different adjuvants (alum, complete Freund s adjuvant, Quil A, AdjuPrime and Ribi) to stimulate humoral and T-cell mediated immune responses against a purified chimeric virus particle was investigated. Each adjuvant was administered subcutaneously to adult mice together with 10 microg of wildtype (
- Mucosal administration of a chimera composed of Pseudomonas exotoxin and the gp120 V3 loop sequence of HIV-1 induces both salivary and serum antibody responses.
- Vaccine. 1999 Mar 17;17(11-12):1425-33. Unique Identifier : AIDSLINE MED/99210153
- Mrsny RJ; Daugherty AL; Fryling CM; FitzGerald DJ; Department of Pharmaceutical Research and Development, Genetech; Inc., South San Francisco, CA 94080-4990, USA. mrsny@gene.com
- We have used a mouse immunization model to evaluate the potential for a chimera protein composed of a nontoxic form of Pseudomonas exotoxin (ntPE) to incite and sustain a mucosal immune response against an integrated antigen. The chimera, termed ntPE-V3MN26, contained 26 amino acids of the gp120 V3 loop region sequenc
- Recognition of HIV-derived B and T cell epitopes displayed on filamentous phages.
- Vaccine. 1999 Mar 17;17(11-12):1434-41. Unique Identifier : AIDSLINE MED/99210154
- De Berardinis P; D'Apice L; Prisco A; Ombra MN; Barba P; Del Pozzo G; Petukhov S; Malik P; Perham RN; Guardiola J; Institute of Protein Biochemistry and Enzymology, CNR, Naples,; Italy.
- The amino acid sequence of HIV reverse transcriptase (RT) from residue 248 to residue 262 was expressed on the surface of filamentous phage fd, fused to the major coat protein gVIIIp. The chimeric phage was used to assess the ability of anti-RT (248-262) human T cell lines and clones to become activated by the phage-d
- A novel epitope R7V common to all HIV-1 isolates is recognized by neutralizing IgG found in HIV-infected patients and immunized rabbits.
- Vaccine. 1999 Mar 17;17(11-12):1454-61. Unique Identifier : AIDSLINE MED/99210156
- Galea P; Le Contel C; Chermann JC; INSERM Unite 322-Unite de Recherche sur les Retrovirus et; Maladies associees, Universite de la Mediterranee, Parc; Scientifique et Technologique de Luminy, Marseilles, France.
- We have previously reported that the presence of antibodies (Ab) directed to the beta2-microglobulin-derived peptide R7V in patient s serum correlated with the nonprogression to AIDS. In order to investigate whether R7V motif could represent a potential target for neutralization, we have immunopurified anti-R7V Ab fro
- Identification of an active Chi recombinational hot spot within the HIV-1 envelope gene: consequences for development of AIDS vaccines.
- Unique Identifier : AIDSLINE MED/99210157
- Prljic J; Veljkovic N; Doliana R; Colombatti A; Johnson E; Metlas R; Veljkovic V
- Because of a sequence similarity between the HIV-1 envelope glycoprotein gp120 and the variable region of human immunoglobulins, we have suggested that the use of this protein as a vaccine component could strongly influence the host immune system, making it more vulnerable to HIV, and in the long term, accelerate dise
- Immunogenicity of synthetic HIV-1 V3 loop peptides by MPL adjuvanted pH-sensitive liposomes.
- Vaccine. 1999 Mar 17;17(11-12):1540-8. Unique Identifier : AIDSLINE MED/99210166
- Chang JS; Choi MJ; Kim TY; Cho SY; Cheong HS; Drug Delivery Research Laboratory, Mogam Biotechnology Research; Institute, Yongin city, Kyonggi-do, South Korea.
- A successful HIV-1 vaccine should be capable of generating humoral and cellular immune responses at the same time. The only response shown to be effective in this regard is virus-neutralization antibodies and virus-specific cytotoxic T-lymphocytes (CTL) directed against the viral antigens. In the present study, it is
- Is there an advantage to including the nucleoprotein in a rabies glycoprotein subunit vaccine?
- Vaccine. 1999 Mar 17;17(11-12):1549-57. Unique Identifier : AIDSLINE MED/99210167
- Drings A; Jallet C; Chambert B; Tordo N; Perrin P; Laboratoire des Lyssavirus, Institut Pasteur, Paris, France.
- A successful HIV-1 vaccine should be capable of generating humoral and cellular immune responses at the same time. The only response shown to be effective in this regard is virus-neutralization antibodies and virus-specific cytotoxic T-lymphocytes (CTL) directed against the viral antigens. In the present study, it is
- A novel vaccine regimen utilizing DNA, vaccinia virus and protein immunizations for HIV-1 envelope presentation.
- Vaccine. 1999 Mar 17;17(11-12):1567-72. Unique Identifier : AIDSLINE MED/99210169
- Caver TE; Lockey TD; Srinivas RV; Webster RG; Hurwitz JL; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, TN 38105, USA.
- Recombinant DNA and vaccinia virus (VV) vectors that express envelope (Env) proteins of the human immunodeficiency virus (HIV) have each been prominently utilized in vaccine development. These two vectors (termed DNA-Env and VV-Env) are attractive vaccine candidates due to their abilities to elicit both cytotoxic T-ly
- Fine needle aspiration of solid tumors in HIV-positive patients [letter]
- Acta Cytol. 1999 May-Jun;43(3):510-2. Unique Identifier : AIDSLINE MED/99279008
- Gattuso P; Kluskens L; Reddy V; Green L; Attal H; Yu G; Lankford K
- Influence of body mass index, sex and age on serum alanine aminotransferase (ALT) level in healthy blood donors.
- Acta Gastroenterol Belg. 1999 Jan-Mar;62(1):16-20. Unique Identifier : AIDSLINE MED/99266137
- Leclercq I; Horsmans Y; De Bruyere M; Geubel AP; Service de Gastro-enterologie, Centre de Transfusion sanguine de; la Croix-Rouge, Bruxelles, Belgique.
- BACKGROUND AND AIM: Serum alanine aminotransferase (ALT) level is the most common screening test as part of a routine evaluation of liver damage. In order to determine the factors influencing this liver function test in normal subjects, the relationship between ALT level and gender, age and body mass index (BMI) was s
- Viral hepatitis and pregnancy.
- Acta Gastroenterol Belg. 1999 Jan-Mar;62(1):21-9. Unique Identifier : AIDSLINE MED/99266138
- Michielsen PP; Van Damme P; Division of Gastroenterology, University of Antwerp,; Antwerpen-Wilrijk.
- This paper reviews data on the mutual relationship between pregnancy and viral hepatitis and the mother-to-infant transmission of the virus. In the western world, hepatitis A, B or C do not seem to influence the course of pregnancy, or to be associated with foetal risks. In contrast, women who contract a hepatitis E i
- Epidemiology of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8.
- Adv Cancer Res. 1999;76:121-60. Unique Identifier : AIDSLINE MED/99234723
- Schulz TF; Department of Medical Microbiology and Genitourinary Medicine,; University of Liverpool, United Kingdom.
- Youth living with HIV as peer leaders.
- Am J Community Psychol. 1999 Feb;27(1):1-23. Unique Identifier : AIDSLINE MED/99251109
- Luna GC; Rotheram-Borus MJ; Department of Psychiatry, University of California, Los Angeles; 90024, USA.
- Community-based service providers often hire youth living with HIV (YLH) as peer leaders for delivering HIV education to uninfected adolescents. Life narratives were collected from 44 YLH during a hypotheses-generating two-year ethnographic study. About 30% of the youth were employed as peer educators. While 60% of th
- The relationship between health and human services and the personal goal-directed activities of persons living with AIDS.
- Am J Community Psychol. 1999 Feb;27(1):55-73. Unique Identifier : AIDSLINE MED/99251111
- DuMont KA; Rapkin BD; Smith MY; Correa A; Palmer S; Cohen S; Department of Psychology, New York University, New York 10003,; USA.
- This study evaluates the relationship between the social climate from different services and the personal goal-directed activities of 224 individuals with AIDS. The study s results supported the main hypothesis that recipient and participatory service involvement uniquely influence personal goal-directed activitie
- Provider-to-patient transmission [news]
- Am J Nurs. 1999 May;99(5):17. Unique Identifier : AIDSLINE MED/99266334
- Morphological, histochemical, immunohistochemical, and ultrastructural characterization of tumors and dysplastic and non-neoplastic lesions arising in BK virus/tat transgenic mice.
- Am J Pathol. 1999 Apr;154(4):1231-44. Unique Identifier : AIDSLINE MED/99252439
- Altavilla G; Trabanelli C; Merlin M; Caputo A; Lanfredi M; Barbanti-Brodano G; Corallini A; Institute of Pathologic Anatomy and Histology, University of; Padova, Padova, Italy. altavill@ux1.unipd.it
- To study the role in AIDS pathogenesis of the human immunodeficiency virus type 1 (HIV-1) Tat protein, a transactivator of viral and cellular genes, we generated transgenic mice with a recombinant DNA containing BK virus (BKV) early region and the HIV-1 tat gene, directed by its own promoter-enhancer. DNA hybridizatio
- Prevalence of antibody to human T cell lymphotropic virus types 1/2 among aboriginal groups inhabiting northern Argentina and the Amazon region of Peru.
- Am J Trop Med Hyg. 1999 Apr;60(4):623-9. Unique Identifier : AIDSLINE MED/99275994
- Medeot S; Nates S; Recalde A; Gallego S; Maturano E; Giordano M; Serra H; Reategui J; Cabezas C; Institute of Virology J.M. Vanella, School of Medicine, National; University of Cardoba, Argentina.
- We carried out a seroepidemiologic survey to define the prevalence of human T cell lymphotropic virus types 1/2 (HTLV-1/2) infections among aboriginal populations from isolated regions of northern Argentina and the Amazon region of
- Increased frequency of Th2-type cytokine-producing T cells in microfilaremic loiasis.
- Am J Trop Med Hyg. 1999 Apr;60(4):680-6. Unique Identifier : AIDSLINE MED/99276004
- Winkler S; Willheim M; Baier K; Aichelburg A; Kremsner PG; Graninger W; Department of Internal Medicine I, and Institute of General and; Experimental Pathology, University of Vienna, Austria.
- The frequency of cytokine-producing peripheral blood mononuclear cells was assessed in 28 subjects with microfilaremic loiasis and in 14 amicrofilaremic individuals. In addition, a subgroup of seven microfilaremic individuals coinfected with Plasmodium malariae was evaluated. By using flow cytometry for the intracellu
- Diarrheal disease in patients infected with human immunodeficiency virus in Bangkok, Thailand.
- Am J Trop Med Hyg. 1999 May;60(5):871-4. Unique Identifier : AIDSLINE MED/99274465
- Wanke CA; Cohan D; Thummakul T; Jongwuitiwes S; Grayson ML; Hammer SM; Hanvanich M; Department of Medicine, Beth Israel Deaconess Medical Center,; Boston, Massachusetts 02215, USA.
- Diarrheal disease and its associated morbidities occur frequently in patients infected with human immunodeficiency virus (HIV) and may be associated with a decreased quality of life. We studied the spectrum of symptoms, measures of nutritional status, and the enteric pathogens associated with diarrheal disease in a gr
- Malaria as a possible evolutionary cause of allergy.
- Allergy. 1999 Feb;54(2):188-9. Unique Identifier : AIDSLINE MED/99236636
- Bottini N; Ronchetti MP; Gloria-Bottini F; Fontana L; Cattedra di Allergologia ed Immunologia Clinica, Ospedale S.; Eugenio, Rome, Italy.
- [The setting of pediatric AIDS]
- An R Acad Nac Med (Madr). 1998;115(4):937-51; discussion 951-6. Unique Identifier : AIDSLINE MED/99274927
- Lucas Tomas M
- Microglia as mediators of inflammatory and degenerative diseases.
- Annu Rev Neurosci. 1999;22:219-40. Unique Identifier : AIDSLINE MED/99218863
- Gonzalez-Scarano F; Baltuch G; Department of Neurology, University of Pennsylvania Medical; Center, Philadelphia 19104-6146, USA. Scarano@mail.med.upenn.edu
- Microglia are the principal immune cells in the central nervous system (CNS) and have a critical role in host defense against invading microorganisms and neoplastic cells. However, as with immune cells in other organs, microglia may play a dual role, amplifying the effects of inflammation and mediating cellular degene
- Michellamine alkaloids inhibit protein kinase C.
- Arch Biochem Biophys. 1999 May 1;365(1):25-30. Unique Identifier : AIDSLINE MED/99240472
- White EL; Chao WR; Ross LJ; Borhani DW; Hobbs PD; Upender V; Dawson MI; Department of Biochemistry, Southern Research Institute,; Birmingham, Alabama 35205, USA. white@sri.org
- Michellamines A, B, and C have shown antiviral activity against HIV-1 and HIV-2 in cell culture. They act in a complex manner by at least two reported antiviral mechanisms, inhibition of HIV reverse transcriptase and inhibition of HIV-induced cellular fusion. On the basis of their structural similarity to other protei
- Major surgery suppresses maximal production of helper T-cell type 1 cytokines without potentiating the release of helper T-cell type 2 cytokines.
- Arch Surg. 1999 May;134(5):540-4. Unique Identifier : AIDSLINE MED/99255006
- Berguer R; Bravo N; Bowyer M; Egan C; Knolmayer T; Ferrick D; Department of Surgery, University of California, Davis, USA.; berguer.ramon@martinez.va.gov
- BACKGROUND: Major surgery is known to suppress T-cell function; however, its differential effects on the production of helper T-cell type 1 (T(H)1) and type 2 (T(H)2) cytokines remains unknown. OBJECTIVE: To measure the production patterns of T(H)1 (interleukin 2 [ IL-2
- The impact of residency training on physicians' AIDS-related treatment practices: a longitudinal panel study.
- Acad Med. 1999 May;74(5):532-8. Unique Identifier : AIDSLINE MED/99279727
- Yedidia MJ; Berry CA; Wagner Graduate School of Public Service, New York University,; New York 10003, USA. mjy2@is2.nyu.edu
- PURPOSE: To determine the effects of aspects of residency training on AIDS-related treatment practices. METHOD: The authors conducted a nationwide longitudinal panel study of 394 physicians who graduated in 1989 from six medical schools in New York State. Data were collected during the participants fourth year of med
- A risk-benefit assessment of HIV protease inhibitors.
- Drug Saf. 1999 Apr;20(4):299-321. Unique Identifier : AIDSLINE MED/99247195
- Moyle GJ; Gazzard BG; Chelsea and Westminster Hospital, London, England.
- The use of triple regimens, often called highly active antiretroviral therapy (HAART), generally involving 2 nucleoside analogues and an HIV protease inhibitor, have been endorsed as the standard of care for persons with HIV initiating therapy by a number of sets of international guidelines. The widespread availabilit
- Transient Tat activation of the HIVLAV/Lai-1 LTR by primary HIV-1 phenotypic variants in HeLaT4LTRbeta-gal cells.
- APMIS. 1999 May;107(5):485-92. Unique Identifier : AIDSLINE MED/99266984
- Nilsen MV; Asjo B; Sommerfelt MA; Department of Molecular Biology, The Gade Institute, Bergen High; Technology Centre, University of Bergen, Norway.
- The rapid/high and slow/low phenotypic variants of primary HIV-1 isolates can be distinguished by their differential co-receptor utilization and their ability to productively infect established cell lines. To reveal possible differences in Tat-mediated transactivation, the potential for primary isolate Tat proteins to
- Human immunodeficiency virus prevalence in women at delivery using unlinked anonymous testing of newborns in the Malaysian setting.
- J Paediatr Child Health. 1999 Feb;35(1):63-6. Unique Identifier : AIDSLINE MED/99250897
- Amar HS; Ho JJ; Mohan AJ; Department of Paediatrics, Ipoh Hospital, Malaysia.; amimar@pc.jaring.my
- OBJECTIVE: To determine the community prevalence of human immunodeficiency virus (HIV) in women at the time of delivery in a Malaysian setting. METHODOLOGY: Cord blood samples from a pilot screening programme for congenital hypothyroidism in 1995 at Ipoh city and surrounding district hospitals were screened anonymousl
- The pharmacokinetics and safety profile of oral ganciclovir in combination with trimethoprim in HIV- and CMV-seropositive patients.
- Br J Clin Pharmacol. 1999 Mar;47(3):255-9. Unique Identifier : AIDSLINE MED/99233286
- Jung D; AbdelHameed MH; Hunter J; Teitelbaum P; Dorr A; Griffy K; Roche Global Development, Palo Alto, CA 94304, USA.
- AIMS: We investigated the pharmacokinetics and safety profile of oral ganciclovir coadministered with trimethoprim in HIV-and CMV-seropositive patients. METHODS: In an open-label, randomized, 3-way crossover study, 12 adult males received oral ganciclovir 1000 mg every 8h, oral trimethoprim 200 mg once daily, or both
- Genetic characterization of HHV-8/KSHV-positive primary effusion lymphoma reveals frequent mutations of BCL6: implications for disease pathogenesis and histogenesis.
- Genes Chromosomes Cancer. 1999 Jan;24(1):16-23. Unique Identifier : AIDSLINE MED/99107122
- Gaidano G; Capello D; Cilia AM; Gloghini A; Perin T; Quattrone S; Migliazza A; Lo Coco F; Saglio G; Ascoli V; Carbone A; Department of Medical Sciences, University of Torino at Novara,; Italy. giadano@med.no.unipmn.it
- Human herpesvirus-8/Kaposi sarcoma-associated herpesvirus-positive primary effusion lymphoma (PEL) is a recently identified B-cell non-Hodgkin lymphoma category characterized by liquid growth in the serous body cavities. Apart from viral infection, no genetic alteration is known to be associated with PEL and no recurr
- Repression of the human immunodeficiency virus type 1 promoter by the human KRAB domain results in inhibition of virus production.
- Biochim Biophys Acta. 1999 May 14;1445(2):216-23. Unique Identifier : AIDSLINE MED/99255427
- Herchenroder O; Hahne JC; Meyer WK; Thiesen HJ; Schneider J; Abteilung Virologie, Institut fur Medizinische Mikrobiologie und; Hygiene, Universitat Freiburg, Hermann-Herder-Str. 11, P.O. Box; 820, 79008, Freiburg, Germany.
- The Kruppel-associated box (KRAB) domain has been described as a eukaryotic repressor of transcription. We show that fusion of KRAB to DNA-binding-domains provides a novel approach to inhibit expression of a replication-competent human immunodeficiency virus (HIV) genome. The KRAB domain from the human zinc finger pro
- [Spatial structure of the rp142 peptide containing the immunodominant epitope of the HIV-1 gp120 protein. A theoretical study]
- Biofizika. 1999 Jan-Feb;44(1):10-7. Unique Identifier : AIDSLINE MED/99260838
- Andrianov AM; Akhrem AA; Institute of Bioorganic Chemistry, Belarussian Academy of; Sciences, Minsk, Belarus.
- A model of spatial structure of the synthetic peptide rp142 (24 amino acid residues) containing the immunodominant epitope of the HIV-1 protein gp120 in the region Gly-10-Phe-15 was constructed by the method of constrained molecular mechanics, which uses the algorithms of theoretical conformational analysis, based o
- Adenoviral vectors expressing lymphotactin and interleukin 2 or lymphotactin and interleukin 12 synergize to facilitate tumor regression in murine breast cancer models [see comments]
- Hum Gene Ther. 1999 Mar 20;10(5):697-709. Unique Identifier : AIDSLINE MED/99224844
- Emtage PC; Wan Y; Hitt M; Graham FL; Muller WJ; Zlotnik A; Gauldie J; Department of Pathology, McMaster University, Hamilton, Ontario,; Canada.
- We have previously demonstrated that intratumoral injection with Ad vectors expressing IL-2 or IL-12 can induce regression in a murine breast cancer model. These IL-2- or IL-12-induced antitumor responses were mainly mediated by Ag-specific T cells. Lymphotactin is a n
- Risk factors for herpes simplex virus type 2 infection among female commercial sex workers in Mexico City.
- Int J STD AIDS. 1999 Feb;10(2):105-11. Unique Identifier : AIDSLINE MED/99229954
- Uribe-Salas F; Hernandez-Avila M; Juarez-Figueroa L; Conde-Glez CJ; Uribe-Zuniga P; Centro de Investigaciones Sobre Enfermedades Infecciosas,; Instituto Nacional de Salud Publica, Cuernavaca, Morelos,; Mexico. fjuribe@insp3.insp.mx
- A scarce number of studies have been carried out to determine the epidemiology of herpes simplex virus type 2 (HSV-2) infection in female sex workers (FSWs). The objective of this study was to examine the correlates of infection for HSV-2 with socioeconomic and demographic characteristics, sexual behaviour and history
- Factors associated with condom use in the male population of Mexico City.
- Int J STD AIDS. 1999 Feb;10(2):112-7. Unique Identifier : AIDSLINE MED/99229955
- Hernandez-Giron CA; Cruz-Valdez A; Quiterio-Trenado M; Uribe-Salas F; Peruga A; Hernandez-Avila M; Center for Population Health Research, CISP, National Institute; of Public Health, Cuernavaca, Mor. Mexico. chernan@insp3.insp.mx
- Sexually transmitted diseases (STDs) are an important public health problem, due to their medical, social and economic repercussions. Therefore, more knowledge is needed about the sexual behaviour that promotes their spread, in order to improve control and prevention strategies. Our aim was to determine the frequency
- Cryotherapy gas--to use nitrous oxide or carbon dioxide?
- Int J STD AIDS. 1999 Feb;10(2):118-20. Unique Identifier : AIDSLINE MED/99229956
- Maiti H; Cheyne MF; Hobbs G; Jeraj HA; Department of Sexual Health, North Herts NHS Trust, Lister; Hospital, Stevenage, UK.
- Cryotherapy is regularly used in our clinic for treating genital warts. Nitrous oxide was used as the cryogenic gas. Following a health and safety review it was decided to monitor the nitrous oxide levels in the treatment room under different conditions. The Occupational Exposure Standard for nitrous oxide is 100 part
- Referral patterns between primary care and genitourinary medicine.
- Int J STD AIDS. 1999 Feb;10(2):121-3. Unique Identifier : AIDSLINE MED/99229957
- Champion JK; Ross JD; Scottish Centre for Infection and Environmental Health, Glasgow,; UK.
- Many patients attending genitourinary medicine (GUM) clinics are self referred, but some patients initially present to their general practitioner (GP). The aim of this study was to describe the referral pattern of GPs in the Lothian region of Scotland to the local GUM clinic. A questionnaire was completed by all patie
- Genital eczema in an elderly man.
- Int J STD AIDS. 1999 Feb;10(2):124-6. Unique Identifier : AIDSLINE MED/99229958
- Aldeen T; Lau RK; Department of Genito-Urinary Medicine, St George's Hospital,; London, UK.
- Acute airway obstruction in patients with AIDS.
- Int J STD AIDS. 1999 Feb;10(2):127-9. Unique Identifier : AIDSLINE MED/99229959
- Ayles HM; Burton M; DeCock KM; Grant HR; Miller RF; HIV/AIDS Unit, UCL Hospitals, London, UK.
- The use of experimental animal and human models in the study of chancroid pathogenesis.
- Int J STD AIDS. 1999 Feb;10(2):71-9. Unique Identifier : AIDSLINE MED/99229949
- Lewis DA; Department of Genitourinary Medicine and Communicable Disease,; Imperial College School of Medicine at St Mary's, London, UK.
- Palliative care and AIDS: 1--pain.
- Int J STD AIDS. 1999 Feb;10(2):80-6; quiz 87-8. Unique Identifier : AIDSLINE MED/99229950
- Meyer M; Department of Palliative Medicine, St Thomas' Hospital, London,; UK.
- Detection of herpes simplex virus in genital specimens by type-specific polymerase chain reaction.
- Int J STD AIDS. 1999 Feb;10(2):89-92. Unique Identifier : AIDSLINE MED/99229951
- Waldhuber MG; Denham I; Wadey C; Leong-Shaw W; Cross GF; Department of Microbiology, Monash Medical School, Prahran,; Victoria, Australia.
- Viral isolation is the standard method for the detection of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in clinical specimens. This study describes the development of a type-specific polymerase chain reaction (PCR) assay for detection and typing of HSV-1 and HSV-2, and a comparison of its sensitivity with t
- A comparison of the use of Papanicolaou-stained cervical cytological smears with Gram-stained vaginal smears for the diagnosis of bacterial vaginosis in early pregnancy.
- Int J STD AIDS. 1999 Feb;10(2):93-7. Unique Identifier : AIDSLINE MED/99229952
- Lamont RF; Hudson EA; Hay PE; Morgan DJ; Modi V; Ison CA; Taylor-Robinson D; Department of Obstetrics and Gynaecology, Northwick Park and St; Mark's NHS Trust, Northwick Park Hospital, Harrow, Middlesex, UK.
- Our objective is to compare the efficacy of using Papanicolaou (PAP)-stained cervical cytology smears with a standardized method of interpreting Gram-stained vaginal smears for the diagnosis of bacterial vaginosis (BV) in pregnancy. High vaginal smears were Gram-stained and examined by a single observer to characteriz
- HIV infection and related risk behaviours in a disadvantaged youth institution of Sao Paulo, Brazil.
- Unique Identifier : AIDSLINE MED/99229953
- Zanetta DM; Strazza L; Azevedo RS; Carvalho HB; Massad E; Menezes RX; Ferreira DP; Burattini MN; School of Medicine, University of Sao Paulo, Brazil.
- In order to study the prevalence of HIV and related risky behaviours among disadvantaged youth, we interviewed and bled, between December 1994 and April 1995, 1122 young males and 93 young females who were serving time in FEBEM, a state institution that cares for homeless and offender youth of Sao Paulo,
- Predictors of urinary tract infection at the first prenatal visit.
- Epidemiology. 1999 May;10(3):282-7. Unique Identifier : AIDSLINE MED/99245870
- Pastore LM; Savitz DA; Thorp JM Jr; Department of Epidemiology, School of Public Health, University; of North Carolina at Chapel Hill, 27599-7400, USA.
- We identified maternal demographic, behavioral, and medical history factors that predict bacteriuria (that is, symptomatic and asymptomatic urinary tract infection) at prenatal care initiation. We applied logistic regression modeling to data from all prenatal care recipients who delivered during 1990-1993 and resided
- Novel derivatives of phenethyl-5-bromopyridylthiourea and dihydroalkoxybenzyloxopyrimidine are dual-function spermicides with potent anti-human immunodeficiency virus activity.
- Biol Reprod. 1999 Jun;60(6):1419-28. Unique Identifier : AIDSLINE MED/99262210
- D'Cruz OJ; Uckun FM; Drug Discovery Program, Department of Reproductive Biology,; Hughes Institute, St. Paul, Minnesota 55113, USA.
- Sexually active women represent the fastest growing HIV/AIDS (human immunodeficiency virus/acquired immunodeficiency syndrome) risk group. In an effort to develop a vaginal microbicidal contraceptive potentially capable of preventing HIV transmission as well as providing fertility control, we have synthesized novel no
- Protein-RNA recognition.
- Biopolymers. 1998;48(2-3):181-95. Unique Identifier : AIDSLINE MED/99266287
- De Guzman RN; Turner RB; Summers MF; Howard Hughes Medical Institute, Department of Chemistry and; Biochemistry, University of Maryland, Baltimore 21250, USA.
- The x-ray structure of the glutamine aminoacyl tRNA synthetase bound to its cognate tRNA(Gln) and ATP was reported by Steitz and co-workers in 1989, providing the first high resolution structure of a protein-RNA complex. Since then, high resolution structures have been reported for RNA complexes with five other tRNA s
- Molecules associated with human Th1 or Th2 cells.
- Eur Cytokine Netw. 1998 Sep;9(3 Suppl):12-6. Unique Identifier : AIDSLINE MED/99047065
- Annunziato F; Galli G; Cosmi L; Romagnani P; Manetti R; Maggi E; Romagnani S; Institute of Internal Medicine and Immunoallergology, University; of Florence, Italy.
- In the last few years, some surface molecules which preferentially associate with human Th1 or Th2 cells have been described. Th1-related molecules include CD26, membrane IFN-gamma, LAG-3, CCR5 and CXCR3, whereas CD62L, CD30, CCR3, CCR4, CCR8, and in a certain way even CXCR4, preferentially associate with human Th2 ce
- In vitro skewing of TCR transgenic CD4+ T cells from interleukin-2 deficient mice towards Th1 and Th2 in the absence of exogenous interleukin-2.
- Eur Cytokine Netw. 1998 Sep;9(3 Suppl):17-25. Unique Identifier : AIDSLINE MED/99047066
- Santner-Nanan B; Wagner S; Wolf M; Kneitz B; Hunig T; Schimpl A; Institute for Virology and Immunology, University of Wurzburg,; Germany.
- Previous experiments from several groups have indicated that in vitro priming for Th2 cells rigorously requires IL-4 but also depends on IL-2 [1-3]. On the other hand, IL-2 deficient mice characteristically have highly increased serum levels of the Th2-dependent isotyp
- Checkpoints for regulation of development and interferon gamma production by Th1 cells in TCR-transgenic models.
- Eur Cytokine Netw. 1998 Sep;9(3 Suppl):41-2. Unique Identifier : AIDSLINE MED/99047069
- O'Garra A; DNAX Research Institute, Palo Alto, California 94304, USA.
- Ignition of the type 1 response to intracellular infection by dendritic cell-derived interleukin-12.
- Eur Cytokine Netw. 1998 Sep;9(3 Suppl):65-8. Unique Identifier : AIDSLINE MED/99047073
- Sher A; Reis e Sousa C; Laboratory of Parasitic Diseases, National Institute of Allergy; and Infectious Diseases, National Institutes of Health, Bethesda,; MD 20892, USA.
- Host resistance to many intracellular pathogens is dependent on the induction of host IFN-gamma. This response in turn is triggered by the critical initiation cytokine, IL-12. Activated macrophages provide a major source of IL-12 during infection yet are unlikely to be the initial cell to produce the cytokine because
- Isolation and identification of naturally modified C-C chemokines MCP-1, MCP-2 and RANTES: effects of posttranslational modifications on receptor usage, chemotactic and anti-HIV-1 activity.
- Eur Cytokine Netw. 1998 Sep;9(3 Suppl):73-5. Unique Identifier : AIDSLINE MED/99047075
- Proost P; Struyf S; Wuyts A; Menten P; De Meester I; Lambeir AM; Scharpe S; Schols D; De Clercq E; Van Damme J; Laboratory of Molecular Immunology, Rega Institute for Medical; Research, University of Leuven, Belgium.
- Regulation of chemokine receptors in mononuclear phagocytes versus dendritic cells and in the amplification of Th1 versus Th2 responses.
- Eur Cytokine Netw. 1998 Sep;9(3 Suppl):76-80. Unique Identifier : AIDSLINE MED/99047076
- Mantovani A; Allavena P; Sozzani S; Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.; Mantovani@irfmn.mnegri.it
- Restricted replication of non-syncytium-inducing HIV in Th1 and Th2 lymphocytes.
- Eur Cytokine Netw. 1998 Sep;9(3 Suppl):95-6. Unique Identifier : AIDSLINE MED/99047080
- Poli G; Vicenzi E; Panina-Bordignon P; Sinigaglia F; AIDS Immunopathogenesis Unit, DIBIT, San Raffaele Scientific; Institute, Milano, Italy. poli.guido@hsr.it
- Dysregulation of interleukin-2 receptor beta and interleukin-2 receptor gamma expression during HIV infection.
- Eur Cytokine Netw. 1998 Sep;9(3 Suppl):97-101. Unique Identifier : AIDSLINE MED/99047081
- David D; Bani L; Moreau JL; Treilhou MP; Demaison C; Sun K; Fevrier M; Salvucci O; Cayota A; Nakarai T; Chouaib S; de Montalembert M; Joussemet M; Sugamura K; Ritz J; Dupont B; Pialoux G; Theze J; Unite d'Immunogenetique Cellulaire, Departement; d'Immunologie, Institut Pasteur, Paris, France.
- Is there a relation between risk groups or initial CD4 T cell counts and prevalence of seborrheic dermatitis in HIV-infected patients?
- Dermatology. 1999;198(2):126-9. Unique Identifier : AIDSLINE MED/99262292
- Schaub NA; Drewe J; Sponagel L; Gilli L; Courvoisier S; Gyr N; Rufli T; Battegay M; Itin P; Department of Dermatology, Outpatient Clinic, University of; Basel, Switzerland.
- OBJECTIVES: (i) To investigate whether there is a difference in the prevalence of seborrheic dermatitis (SD) between homo- or bisexual HIV-infected patients and HIV-infected intravenous drug users, (ii) to study whether the initial CD4 T cell count at the first positive HIV test is of any significance for the prevalen
- Immune thrombocytopenic purpura in adults: clinical aspects.
- Baillieres Clin Haematol. 1998 Jun;11(2):361-72. Unique Identifier : AIDSLINE MED/99197886
- Gillis S; Eldor A; Department of Hematology, Hadassah Hospital, Jerusalem, Israel.
- Immune thrombocytopenic purpura (ITP) is a relatively common immune-mediated disorder characterized by thrombocytopenia due to clearance of opsonized platelets by the reticuloendothelial system. The acute form, more common in children, is a self-limiting, often post-viral disease. In contrast, the adult form is typica
- Thrombotic thrombocytopenic purpura: diagnosis, pathogenesis and modern therapy.
- Baillieres Clin Haematol. 1998 Jun;11(2):475-95. Unique Identifier : AIDSLINE MED/99197894
- Eldor A; Institute of Hematology, Tel-Aviv Sourasky Medical Center,; Israel.
- Thrombotic thrombocytopenic purpura (TTP) is an uncommon multisystem disorder, sometimes associated with predisposing conditions such as pregnancy, cancer, exposure to certain drugs, bone marrow transplantation and HIV-1 infection. An abnormal interaction between the vascular endothelium and platelets which occurs in
- [Bilateral cystoid macular edema after successful treatment of AIDS-associated cytomegalovirus retinitis]
- Ophthalmologe. 1999 Feb;96(2):87-91. Unique Identifier : AIDSLINE MED/99195058
- Welzl-Hinterkorner E; Tholen H; Sturmer J; Opravil M; Bernauer W; Augenklinik, Universitatsspital, Zurich.
- BACKGROUND: Cystoid macular edema (CME) in AIDS patients with inactive cytomegalovirus ( CMV ) retinitis is an uncommon but potentially sight-threatening complication. The pathogenesis of CME in these patients is unclear. This
- Bipolar disorder in old age.
- Can Fam Physician. 1999 May;45:1229-37. Unique Identifier : AIDSLINE MED/99278684
- Shulman KI; Herrmann N; Department of Psychiatry, University of Toronto, Ontario.; ken.shulman@sunnybrook.on.ca
- OBJECTIVE: To review the classification, clinical characteristics, and epidemiology of bipolar disorders in old age with a special focus on neurologic comorbidity, high mortality, and management. QUALITY OF EVIDENCE: Most available data is gleaned from retrospective chart reviews and cohort studies. Treatment recommen
- High prevalence of antibodies against HERV-K10 in patients with testicular cancer but not with AIDS.
- Unique Identifier : AIDSLINE MED/99224038
- Goedert JJ; Sauter ME; Jacobson LP; Vessella RL; Hilgartner MW; Leitman SF; Fraser MC; Mueller-Lantzsch NG; Viral Epidemiology Branch, National Cancer Institute, Rockville,; Maryland 20852, USA. goedertj@mail.nih.gov
- Human endogenous retrovirus K10 (HERV-K10) env and gag expression has been detected in placenta, embryonic tissue, and cell lines. By transfection, these sequences have been expressed in insect cells and developed into serological assays, revealing HERV-K10 antibodies in patients with testicular cancer. Patients with
- Altered T cell repertoire usage in CD4 and CD8 subsets of multiple myeloma patients, a Study of the Eastern Cooperative Oncology Group (E9487).
- Leuk Lymphoma. 1999 Mar;33(1-2):127-33. Unique Identifier : AIDSLINE MED/99208472
- Kay N; Leong T; Kyle RA; Greipp P; Van Ness B; Bone N; Oken MM; Virginia Piper Cancer Institute, Minneapolis, MN, USA.
- Previous investigations have demonstrated that an expanding circulating T cell population is able to modulate the malignant clone in multiple myeloma. More recently, an expansion of T cell subsets exhibiting a restricted T cell repertoire has been detected in some MM patients. To further elucidate if a selected T cell
- Low incidence of human herpesvirus 8 in stem cell collections from myeloma patients.
- Bone Marrow Transplant. 1999 Apr;23(8):759-61. Unique Identifier : AIDSLINE MED/99246167
- Cull GM; Carter GI; Timms JM; Thomson BJ; Russell NH; Haynes AP; Department of Haematology, University of Nottingham at Nottingham; City Hospital, UK.
- Human herpesvirus 8 is a gammaherpesvirus which may be implicated in the pathogenesis of multiple myeloma. Viral DNA sequences have been found in the bone marrow, peripheral blood and leukapheresis products of myeloma patients. These findings have significant implications for the use of leukapheresed cells in the tran
- CD95 (Fas) ligand expression of Epstein-Barr virus (EBV)-infected lymphocytes: a possible mechanism of immune evasion in chronic active EBV infection.
- Pathol Int. 1999 Jan;49(1):9-13. Unique Identifier : AIDSLINE MED/99242278
- Ohshima K; Suzumiya J; Sugihara M; Nagafuchi S; Ohga S; Kikuchi M; Department of Pathology, School of Medicine, Fukuoka University,; Japan.
- The Epstein-Barr virus (EBV) induces infectious mononucleosis (IM) and can be associated with chronic active EBV infection (CAEBV). Cytotoxic T lymphocytes (CTL) play an important role in excluding EBV-infected cells. Two cytotoxic mechanisms of CTL have been demonstrated: one perforin/granzyme-based and the other Fas
- Lymphocytic alveolitis, bronchoalveolar lavage viral load, and outcome in human immunodeficiency virus infection.
- Am J Respir Crit Care Med. 1999 May;159(5 Pt 1):1439-44. Unique Identifier : AIDSLINE MED/99246476
- Twigg HL; Soliman DM; Day RB; Knox KS; Anderson RJ; Wilkes DS; Schnizlein-Bick CT; Department of Medicine, Indiana University Medical Center,; Indianapolis, Indiana, USA.
- Lymphocytic alveolitis portends a poor prognosis in human immunodeficiency virus (HIV)-infected subjects. Because alveolar lymphocytes consist predominantly of HIV-specific CD8(+) cytotoxic T lymphocytes (CTL), they could represent an appropriate immune response to infected cells in the lung, and be a surrogate marker
- Inflammatory reaction in pulmonary muscular arteries of patients with mild chronic obstructive pulmonary disease.
- Am J Respir Crit Care Med. 1999 May;159(5 Pt 1):1605-11. Unique Identifier : AIDSLINE MED/99246502
- Peinado VI; Barbera JA; Abate P; Ramirez J; Roca J; Santos S; Rodriguez-Roisin R; Serveis de Pneumologia i Al.lergia Respiratoria id'Anatomia; Patologica, Institut d'Investigacions Biomediques Pi i Sunyer,; Barcelona, Spain.
- Endothelial dysfunction and intimal thickening have been shown in pulmonary arteries (PA) of patients with mild chronic obstructive pulmonary disease (COPD). To investigate whether an inflammatory process related to tobacco smoking might be involved in the development of pulmonary vascular abnormalities in COPD, we ch
- Selection of drug-resistant HIV.
- Trends Microbiol. 1999 Mar;7(3):120-3. Unique Identifier : AIDSLINE MED/99226298
- Harrigan PR; Alexander CS; BC Centre for Excellence in HIV/AIDS, Vancouver, Canada.; richard@hivnet.ubc.ca
- Resistance to antiretroviral drugs by HIV develops from competition among several different virus variants within an individual. Recent studies have measured the changing proportions of HIV populations, which differ by single nucleic acids, under the selective pressures exerted by the addition or removal of antiretrov
- Changes in body habitus and serum lipid abnormalities in HIV-positive women on highly active antiretroviral therapy (HAART).
- Unique Identifier : AIDSLINE MED/99287546
- Dong KL; Bausserman LL; Flynn MM; Dickinson BP; Flanigan TP; Mileno MD; Tashima KT; Carpenter CC; Department of Medicine, Brown University, Providence, Rhode; Island, USA.
- Twenty-one women (propositi) who expressed serious concerns about changes in body habitus during highly active antiretroviral therapy (HAART) were evaluated by thorough physical examination, anthropometric measurements, and serum lipid and endocrine assays. The same evaluations were carried out in a comparison group o
- Why is highly active antiretroviral therapy (HAART) not prescribed or discontinued? Swiss HIV Cohort Study.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Jun 1;21(2):114-9. Unique Identifier : AIDSLINE MED/99287547
- Bassetti S; Battegay M; Furrer H; Rickenbach M; Flepp M; Kaiser L; Telenti A; Vernazza PL; Bernasconi E; Sudre P; Outpatient Department of Internal Medicine, University Hospital,; Basel, Switzerland.
- In this cross-sectional survey conducted at the end of 1997 among the physicians of participants of the Swiss HIV Cohort Study (SHCS), 1487 of 2154 patients (69.0%) were treated with highly active antiretroviral treatment (HAART) defined as triple therapy with a combination of one or two reverse transcriptase inhibito
- Heterosexual transmission of HIV-1 is associated with high plasma viral load levels and a positive viral isolation in the infected partner.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Jun 1;21(2):120-5. Unique Identifier : AIDSLINE MED/99287548
- Pedraza MA; del Romero J; Roldan F; Garcia S; Ayerbe MC; Noriega AR; Alcami J; Servicio de Microbiologia, Centro de Investigacion, Hospital 12; de Octubre, Madrid, Spain.
- Risk factors for heterosexual HIV transmission are not fully understood. In fact, a proportion of people with sexual exposure to HIV remain uninfected despite multiple and continuous intercourse with HIV-infected partners. In this work, we have analyzed those virologic parameters potentially involved in the transmissi
- Sensitivity, specificity, reliability, and clinical validity of provider-reported symptoms: a comparison with self-reported symptoms. Outcomes Committee of the AIDS Clinical Trials Group.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Jun 1;21(2):126-33. Unique Identifier : AIDSLINE MED/99287549
- Justice AC; Rabeneck L; Hays RD; Wu AW; Bozzette SA; Department of Veterans Affairs Medical Center, and Case Western; Reserve University School of Medicine, Cleveland, Ohio, USA.; Amy.Justice@med.ua.gov
- BACKGROUND: If symptoms are to be recognized and effectively addressed in clinical research, they must be collected using sensitive, specific, reliable, and clinically meaningful methods. OBJECTIVE: To perform a comparison of self-administered symptom survey data with data from conventional provider-reports. DESIGN/ME
- Validity of two scales in identifying HIV-associated dementia.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Jun 1;21(2):134-40. Unique Identifier : AIDSLINE MED/99287550
- Berghuis JP; Uldall KK; Lalonde B; Department of Psychiatry and Behavioral Sciences, University of; Washington, Seattle 98105, USA.
- OBJECTIVES: To examine and compare the validity of the HIV Dementia Scale (HDS) and Executive Interview (EXIT) in detecting HIV/AIDS dementia . METHODS: The sample included hospitalized or skilled nursing/assisted-living facility (SNF) HIV/AIDS patients (N = 103). Participants compl
- Prevalence of and risk factors for tuberculin positivity and skin test anergy in HIV-1-infected and uninfected at-risk women. Women's Interagency HIV Study (WIHS).
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Jun 1;21(2):141-7. Unique Identifier : AIDSLINE MED/99287551
- Anastos K; Kalish LA; Palacio H; Benson CA; Delapenha R; Chirgwin K; Stonis L; Telzak EE; Montefiore Medical Center, Bronx, New York, USA.; kanastos@cmcny.com
- OBJECTIVES: To determine differences in rates of reactivity to purified protein derivative (PPD) tuberculin and of skin test anergy in relationship to serostatus, immune status, demographic characteristics, and other risk factors in women infected with or at high risk for infection with HIV-1; and to compare the usefu
- Prevalence of sexual and drug-related HIV risk behaviors in the U.S. adult population: results of the 1996 National Household Survey on Drug Abuse.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Jun 1;21(2):148-56. Unique Identifier : AIDSLINE MED/99287552
- Anderson JE; Wilson RW; Barker P; Doll L; Jones TS; Holtgrave D; Division of HIV/AIDS Prevention-Intervention, Research and; Support, National Center for HIV, Sexually Transmitted Diseases; and Tuberculosis Prevention, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333, USA. jea1@cdc.gov
- CONTEXT: Data on the prevalence of HIV risk behavior that are representative of the general population are needed to help evaluate the effectiveness of prevention programs. OBJECTIVE: To use data from a large national interview survey to make estimates of the prevalence of sexual and drug-related HIV risk behaviors in
- Infection by different HIV-1 subtypes (B and C) results in a similar immune activation profile despite distinct immune backgrounds.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Jun 1;21(2):157-63. Unique Identifier : AIDSLINE MED/99287553
- Weisman Z; Kalinkovich A; Borkow G; Stein M; Greenberg Z; Bentwich Z; R. Ben-Ari Institute of Clinical Immunology, AIDS Center, Kaplan; Medical Center, Hebrew University Hadassah Medical School,; Rehovot, Israel.
- We compared the immune activation profile of 46 HIV-negative and 75 HIV-positive Israelis infected with HIV-1 subtype B, with 85 HIV-negative and 102 HIV-positive Ethiopian immigrants to Israel, who were infected with HIV subtype C. The HIV-negative Ethiopians had exceedingly high blood levels of eosinophils, immunogl
- Increase of HIV-1 subtype A in Central African Republic.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Jun 1;21(2):164-71. Unique Identifier : AIDSLINE GENBANK/M81065
- Muller-Trutwin MC; Chaix ML; Letourneur F; Begaud E; Beaumont D; Deslandres A; You B; Morvan J; Mathiot C; Barre-Sinoussi F; Saragosti S; Unite de Biologie des Retrovirus, Institut Pasteur, Paris,; France.
- The concomitant presence of five distinct HIV-1 subtypes and of unclassified HIV-1 was reported in Bangui, Central African Republic (C.A.R.) between 1990 and 1991. This previous study was conducted in individuals belonging to the C.A.R. Armed Forces (FACA) Cohort an
- Prevalence of HIV-1 among recent arrestees in Los Angeles County, California: serial cross-sectional study, 1991-1995.
- Unique Identifier : AIDSLINE MED/99287555
- Carpenter CL; Longshore D; Annon K; Annon JJ; Anglin MD; Department of Preventive Medicine, University of Southern; California School of Medicine, Los Angeles 90033, USA.; ccarpent@rcf.usc.edu
- Injection drug users (IDU), crack smokers, and commercial sex workers engage in illegal activities that place them at risk for HIV infection. The marginalized nature of these groups often limits use of customary sampling methods to assess HIV prevalence. We tested urine samples of recent arrestees to evaluate HIV prev
- Salivary sIgA response in HIV-1 infection.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Jun 1;21(2):73-80. Unique Identifier : AIDSLINE MED/99287542
- Skott P; Lucht E; Julander I; Dillner J; Bjorling E; The Microbiology and Tumorbiology Center at Karolinska Institute,; Stockholm, Sweden.
- Local and systemic production of total and HIV-1 specific IgA was determined in whole saliva and serum from 45 HIV-1-infected individuals and 15 healthy controls. The antigenic domains important for sIgA and IgG binding, respectively, was investigated with epitope mapping using synthetic peptides of HIV-1 proteins. De
- Role of macrophage protection in the development of murine AIDS.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Jun 1;21(2):81-9. Unique Identifier : AIDSLINE MED/99287543
- Fraternale A; Tonelli A; Casabianca A; Vallanti G; Chiarantini L; Schiavano GF; Benatti U; De Flora A; Magnani M; Institute of Biological Chemistry Giorgio Fornaini, University of; Urbino, Italy.
- Macrophages play a key role in AIDS pathogenesis and thus controlling infectivity and viral replication in these cells is a key issue in any antiretroviral therapy. In the present study, using a murine model of AIDS, we evaluated new therapeutic approaches specifically designed for the protection of macrophages. Based
- Herpes simplex virus chronically infected human T lymphocytes are susceptible to HIV-1 superinfection and support HIV-1 pseudotyping.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Jun 1;21(2):90-8. Unique Identifier : AIDSLINE MED/99287544
- Calistri A; Parolin C; Pizzato M; Calvi P; Giaretta I; Palu G; Institute of Microbiology of the University of Padova, Italy.
- Peripheral blood lymphocytes (PBL) and CEM CD4+ T-cell line can be infected by herpes simplex virus-1 (HSV-1). CEM cells were characterized as a cellular model to study interactions occurring between HSV-1 and HIV-1. Virtually all cells were persistently infected by HSV-1 (CEM(HSV)) and expressed the latency associate
- Comprehensive classification of symptoms and signs reported among 218 patients with acute HIV-1 infection.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Jun 1;21(2):99-106. Unique Identifier : AIDSLINE MED/99287545
- Vanhems P; Dassa C; Lambert J; Cooper DA; Perrin L; Vizzard J; Hirschel B; Kinloch-de Loes S; Carr A; Allard R; Laboratoire d'Epidemiologie et de Sante Publique, Unite INSERM; U 271, Universite Claude-Bernard, Lyon, France.; Philipva@lyon-sud.univ-lyon1.fr
- Acute HIV-1 illness presents a wide range of clinical manifestations. We assessed a classification and data reduction of clinical features among 218 patients with acute HIV-1 infection enrolled in four prospective seroincidence studies. Factor analysis allows the definition of eight factors based on groups of symptoms
- [Viral infectious diseases of the retina]
- Ryoikibetsu Shokogun Shirizu. 1999;(25 Pt 3):336-8. Unique Identifier : AIDSLINE MED/99270113
- Azumi A; Katakami C; Department of Ophthalmology, Kobe University School of Medicine.
- [Vertical infection]
- Ryoikibetsu Shokogun Shirizu. 1999;(25 Pt 3):375-9. Unique Identifier : AIDSLINE MED/99270124
- Minamitani M; Tokyo Metropolitan Komagome Hospital.
- [AIDS-associated infections]
- Ryoikibetsu Shokogun Shirizu. 1999;(25 Pt 3):389-92. Unique Identifier : AIDSLINE MED/99270127
- Ajisawa A; Department of Infectious Diseases, Tokyo Metropolitan Komagome; Hospital.
- [Virus-associated malignancies]
- Ryoikibetsu Shokogun Shirizu. 1999;(25 Pt 3):421-4. Unique Identifier : AIDSLINE MED/99270134
- Takada K; Department of Virology, Hokkaido University School of Medicine.
- Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion.
- Immunity. 1999 May;10(5):537-46. Unique Identifier : AIDSLINE MED/99294319
- Gartner F; Alt FW; Monroe R; Chu M; Sleckman BP; Davidson L; Swat W; Howard Hughes Medical Institute, The Children's Hospital, and The; Center for Blood Research, Harvard Medical School, Boston,; Massachusetts 02115, USA.
- T cell receptor (TCR) beta chain allelic exclusion occurs at the thymocyte CD4- 8- (double-negative, or DN) to CD4+ 8+ (double-positive, or DP) transition, concurrently with differentiation and cellular expansion, and is imposed by a negative feedback loop in which a product of the first rearranged TCRbeta allele arre
- Generation of functional thymocytes in the human adult.
- Immunity. 1999 May;10(5):569-75. Unique Identifier : AIDSLINE MED/99294322
- Jamieson BD; Douek DC; Killian S; Hultin LE; Scripture-Adams DD; Giorgi JV; Marelli D; Koup RA; Zack JA; Department of Medicine, UCLA School of Medicine and Jonsson; Comprehensive Cancer Center, Los Angeles, California 90095-1678,; USA. bjamieso@ucla.edu
- Reconstituting the immune response will be critical for the survival of HIV-infected individuals once viral load is brought under control. While the adult thymus was previously thought to be relatively inactive, new data suggest it may play a role in T cell reconstitution. We examined thymopoiesis in adults up to 56 y
- Granzyme A initiates an alternative pathway for granule-mediated apoptosis.
- Immunity. 1999 May;10(5):595-605. Unique Identifier : AIDSLINE MED/99294325
- Shresta S; Graubert TA; Thomas DA; Raptis SZ; Ley TJ; Department of Internal Medicine and Genetics, Washington; University Medical School, St. Louis, Missouri 63110, USA.
- Granzyme (gzm) B-deficient cytotoxic lymphocytes (CTL) have a severe defect in the rapid induction of target cell apoptosis that is almost completely corrected by prolonged incubation of the CTL effectors and their targets. We show in this report that perforin-dependent, gzmB-independent cytotoxicity is caused by gzmA
- Chance favors the prepared mind--from serendipity to rational drug design.
- J Recept Signal Transduct Res. 1999 Jan-Jul;19(1-4):15-39. Unique Identifier : AIDSLINE MED/99171142
- Kubinyi H; BASF Aktiengesellschaft, Ludwigshafen, Germany.
- Accidental discoveries always played an important role in science, especially in the search for new drugs. Several examples of serendipitous findings, leading to therapeutically useful drugs, are presented and discussed. Captopril, an antihypertensive Angiotensin-converting enzyme inhibitor, was the first drug that co
- Feasibility of an emergency department-based tuberculosis counseling and screening program.
- Acad Emerg Med. 1999 Mar;6(3):224-31. Unique Identifier : AIDSLINE MED/99206893
- Kirsch TD; Chanmugam A; Keyl P; Regan LA; Shahan J; Hexter DA; Kelen GD; Department of Emergency Medicine, Michael Reese Hospital and; Medical Center, Chicago, IL, USA.
- OBJECTIVE: To assess the feasibility and effectiveness of an ED-based tuberculosis (TB) screening program. METHODS: A TB screening program of adult ED patients was conducted at a university hospital ED with 46,000 annual visits that serves a poor urban community. Patients were screened on weekdays during business hour
- HIV seroprevalence across the rural/urban continuum.
- Subst Use Misuse. 1999 Mar-Apr;34(4-5):595-615. Unique Identifier : AIDSLINE MED/99224801
- McCoy CB; Metsch LR; McCoy HV; Weatherby NL; Comprehensive Drug Research Center, Department of Epidemiology; and Public Health, University of Miami School of Medicine,; Florida 33136, USA. cmccoy@mednet.med.miami.edu
- While the first decade of the AIDS epidemic was characterized by high prevalence rates of AIDS infection in urban areas, there is increasing recognition of the spread of HIV into rural communities in the United States . Data from the Miami CARES cohort collected on 3,555 chronic drug us
- Opportunities for AIDS prevention in a rural state in criminal justice and drug treatment settings.
- Subst Use Misuse. 1999 Mar-Apr;34(4-5):617-31. Unique Identifier : AIDSLINE MED/99224802
- Farabee D; Leukefeld CG; Center on Drug and Alcohol Research, University of Kentucky,; Lexington 40504, USA.
- This study examined the likelihood that drug users would receive HIV/ AIDS prevention information and supplies (e.g., condoms and bleach) in the rural state of Kentucky. Despite evidence of high HIV risk among criminal justice and substance-using populations, incarceration and substance-user treatment were only minima
- AIDS susceptibility in a migrant population: perception and behavior.
- Subst Use Misuse. 1999 Mar-Apr;34(4-5):633-52. Unique Identifier : AIDSLINE MED/99224803
- McBride DC; Weatherby NL; Inciardi JA; Gillespie SA; Behavioral Science Department, Andrews University, Berrien; Springs, Michigan 49104-0030, USA.
- Within the framework of the Health Belief Model, this paper examines correlates of perception of AIDS susceptibility among 846 drug-using migrant farm workers and their sex partners. Significant but relatively small differences by ethnicity and gender were found. The data showed a consistent significant statistical re
- Drug use and HIV risks among migrant workers on the DelMarVa Peninsula.
- Subst Use Misuse. 1999 Mar-Apr;34(4-5):653-66. Unique Identifier : AIDSLINE MED/99224804
- Inciardi JA; Surratt HL; Colon HM; Chitwood DD; Rivers JE; Center for Drug and Alcohol Studies, University of Delaware,; Newark, USA.
- Because high rates of drug use have been documented in the migrant farm worker population, the National Institute on Drug Abuse funded the Migrant Health Study to examine HIV risk behaviors among drug-using farm workers and their sexual partners. Many of these individuals were home-based in South Florida and migrated
- Behavior changes among crack-using rural and urban women.
- Subst Use Misuse. 1999 Mar-Apr;34(4-5):667-84. Unique Identifier : AIDSLINE MED/99224805
- McCoy HV; McCoy CB; Lai S; Weatherby NL; Messiah S; Department of Public Health, Florida International University,; North Miami 33181, USA. mccoyh@servax.fiu.edu
- This study compared rural and urban crack-using women and examined their responses to two interventions. A prospective cohort study design was employed to assess the effectiveness of standard and innovative HIV prevention interventions on 541 urban and 268 rural women in Florida. Generalized estimating equation analys
- Crack cocaine use in rural migrant populations: living arrangements and social support.
- Subst Use Misuse. 1999 Mar-Apr;34(4-5):685-706. Unique Identifier : AIDSLINE MED/99224806
- Weatherby NL; McCoy HV; Metsch LR; Bletzer KV; McCoy CB; de la Rosa MR; Comprehensive Drug Research Center, University of Miami, Florida; 33136, USA. nweather@mednet.med.miami.edu
- Correlates of crack cocaine use were studied among a targeted sample of migrant workers and their sexual partners (n = 571) in rural Southern Florida. Employment among men and recent drug-user treatment among men and women are positively related to crack use, as is involvement in crime and prostitution. Among women bu
- Recommendations to bridge rural/urban drug-use(r) research and practice.
- Subst Use Misuse. 1999 Mar-Apr;34(4-5):785-93. Unique Identifier : AIDSLINE MED/99224811
- Leukefeld CG; Edwards RW; Center on Drug and Alcohol Research, University of Kentucky,; Lexington, USA.
- This article presents recommendations developed by a group of United States drug-use(r) researchers interested in rural and urban research and practice who met in Lexington, Kentucky, in October 1996. Overall, there was consensus about the importance of better understanding the urban/r
- Pre-AIDS mortality and morbidity among injection drug users in Amsterdam and Baltimore: an ecological comparison.
- Subst Use Misuse. 1999 May;34(6):845-65. Unique Identifier : AIDSLINE MED/99243701
- van Ameijden EJ; Krol A; Vlahov D; Flynn C; van Haastrecht HJ; Coutinho RA; Division of Public Health and Environment, Municipal Health; Service, Amsterdam, The Netherlands. evameijden@GGGD.amsterdam.nl
- Mortality and morbidity between injecting drug users in Amsterdam (n = 624) and Baltimore (n = 2,185) are compared to generate a hypothesis about the role of different health care systems and drug user policies (universal care and harm reduction versus episodic care and criminalization, respectively). Overdose/suicide
- Rate and severity of HIV-associated dementia (HAD): correlations with Gp41 and iNOS.
- Mol Med. 1999 Feb;5(2):98-109. Unique Identifier : AIDSLINE MED/99221885
- Adamson DC; McArthur JC; Dawson TM; Dawson VL; Department of Neurology, Johns Hopkins University School of; Medicine, Baltimore, Maryland, USA.
- BACKGROUND: Fifteen to thirty percent of AIDS patients develop some type of neurologic disorder during the course of their illness and the vast majority of these neurologic disorders will be HIV-associated dementia (HAD). These patients can exhibit varying degrees of severity and r
- Association between chronic lymphocytic leukemia and sarcoidosis: clinical value of bronchoalveolar lavage.
- Sarcoidosis Vasc Diffuse Lung Dis. 1999 Mar;16(1):101-3. Unique Identifier : AIDSLINE MED/99224355
- Marruchella A; Epis R; Camerone G; Tondini M; Divisione di Broncopneumologia, Ospedale E. Morelli, Sondalo,; Italy.
- We report a case of sarcoidosis, occurred in a patient with chronic lymphocytic leukemia (CLL) shortly following the completion of initial chemotherapy, who relapsed shortly after a second course. Since bronchoalveolar lavage (BAL) demonstrated a predominance of CD4+ lymphocytes, it largely excluded spread of the mali
- Cells and cytokines involved in the pathogenesis of sarcoidosis.
- Sarcoidosis Vasc Diffuse Lung Dis. 1999 Mar;16(1):24-31. Unique Identifier : AIDSLINE MED/99224346
- Moller DR; Johns Hopkins University School of Medicine, Baltimore, MD 21224,; USA. dmoller@welchlink.welch.jhu.edu
- Granulomatous inflammation develops under the regulatory influence of cytokines produced by local mononuclear phagocytes, T cells, dendritic cells, fibroblasts, and other local cells. In sarcoidosis, granulomatous inflammation is characterized by dominant expression of T helper 1 (Th1) cytokines such as IFN gamma and
- HIV laws: a new shift in focus [editorial]
- Aids Patient Care STDS. 1999 Mar;13(3):145-7. Unique Identifier : AIDSLINE MED/99212511
- Laurence J
- Megestrol acetate: promises and pitfalls.
- Aids Patient Care STDS. 1999 Mar;13(3):149-52. Unique Identifier : AIDSLINE MED/99212512
- Farrar DJ; Center for Special Studies, New York Hospital-Cornell Medical; Center, New York, USA.
- Recent reports suggest that effective antiretroviral therapy, resulting in a plasma HIV load that has been reduced to undetectable levels, may itself prevent HIV- and opportunistic infection-associated weight loss and lead to substantial weight gain. Although these data are encouraging, it is clear that a significant
- HIV-associated dementia: new insights into disease pathogenesis and therapeutic interventions.
- Aids Patient Care STDS. 1999 Mar;13(3):153-63. Unique Identifier : AIDSLINE MED/99212513
- Swindells S; Zheng J; Gendelman HE; Center for Neurovirology and Neurodegenerative Disorders,; University of Nebraska Medical Center, Omaha, USA.; sswindel@aries.unmc.edu
- Remarkable progress was made in recent years in the therapeutics of HIV-1-associated dementia (HAD) and in unraveling the complex pathophysiology that follows viral invasion of the central nervous system (CNS). Viral replication in and outside of the CNS was significantly reduced i
- HIV/AIDS rounds: HIV in children.
- Aids Patient Care STDS. 1999 Mar;13(3):165-73. Unique Identifier : AIDSLINE MED/99212514
- Cervia J; Department of Pediatrics, Cornell University Medical College, New; York, New York, USA.
- Differences in curable STDs between HIV and non-HIV populations in Spain.
- Unique Identifier : AIDSLINE MED/99212515
- Garcia-Lechuz JM; Rivera M; Catalan P; Sanchez-Carrillo C; Rodriguez-Creixems M; Bouza E
- The pandemic impact of HIV has changed the clinical spectrum of STDs all over the world. The incidence and frequency of STDs in the different global geographic areas demonstrate the diagnostic and treatment capabilities of various local and national health systems and is simultaneously informing about the sexual behav
- Prevalence of enteric pathogens in HIV-related diarrhea in the midwest.
- Aids Patient Care STDS. 1999 Mar;13(3):179-84. Unique Identifier : AIDSLINE MED/99212516
- Bonacini M; Skodras G; Quiason S; Kragel P; Division of Gastroenterology and Liver Diseases, U.S.C. School of; Medicine, Los Angeles, California, USA.
- HIV disease is often associated with the condition of diarrhea, which may be accompanied by enteric infection or gastrointestinal tumor. This study prospectively investigated 27 episodes of chronic diarrhea in 24 patients with HIV infection. Upper endoscopy and sigmoidoscopy with biopsies at three sites (distal duoden
- Predictors of self-reported adherence in persons living with HIV disease.
- Aids Patient Care STDS. 1999 Mar;13(3):185-97. Unique Identifier : AIDSLINE MED/99212517
- Holzemer WL; Corless IB; Nokes KM; Turner JG; Brown MA; Powell-Cope GM; Inouye J; Henry SB; Nicholas PK; Portillo CJ; University of California, San Francisco, USA.
- This study examined the relationships between the five dimensions of the Wilson and Cleary model of health-related quality of life and three self-reported adherence measures in persons living with HIV using a descriptive survey design. Data collection occurred in seven cities across the Un
- ABT-378 lowers viral load [news]
- Aids Patient Care STDS. 1999 Mar;13(3):199. Unique Identifier : AIDSLINE MED/99212518
- Directly observed HAART [news]
- Aids Patient Care STDS. 1999 Mar;13(3):199-200. Unique Identifier : AIDSLINE MED/99212519
- HBV resistance in HIV patients [news]
- Aids Patient Care STDS. 1999 Mar;13(3):200. Unique Identifier : AIDSLINE MED/99212520
- Trial will evaluate cyclosporine [news]
- Aids Patient Care STDS. 1999 Mar;13(3):202. Unique Identifier : AIDSLINE MED/99212524
- Impact of individualized counseling on HIV infection rates.
- Aids Patient Care STDS. 1999 Mar;13(3):203-5. Unique Identifier : AIDSLINE MED/99212526
- Makulowich GS
- Getting a high response rate of sexual behavior survey among the general population in Japan: three different methods of survey on sexual behavior.
- J Epidemiol. 1999 Apr;9(2):107-13. Unique Identifier : AIDSLINE MED/99269377
- Hayashi M; Iwanaga T; Mitoku K; Minowa M; Department of Public Health, Juntendo University, School of; Medicine, Tokyo, Japan.
- The purpose of this study was to specify the most accurate, reliable and valid technique for a general sexual behavioral survey in Japan . This pilot study was conducted to assure a high response rate and to keep respondents privacy confidential by using an anonymous questionnaire s
- Trend of HIV incidence rates among drug users in an HIV epicenter in northern Thailand (1989-1997).
- J Epidemiol. 1999 Apr;9(2):114-20. Unique Identifier : AIDSLINE MED/99269378
- Sawanpanyalert P; Supawitkul S; Yanai H; Saksoong P; Piyaworawong S; Department of Medical Services, Ministry of Public Health,; Nonthaburi, Thailand.
- OBJECTIVES: To determine trends and associated risk factors of HIV incidence (1989-1997) in a drug abuse treatment clinic in northern Thailand where HIV is epidemic. DESIGN: Retrospective cohort study. METHODS: Nine-years (1989-1997) of data (excluding names) from the logbook of
- Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans.
- Clin Microbiol Rev. 1999 Jan;12(1):80-96. Unique Identifier : AIDSLINE MED/99123069
- Fidel PL Jr; Vazquez JA; Sobel JD; Department of Microbiology, Immunology, and Parasitology,; Louisiana State University Medical Center, New Orleans, Louisiana; 70112, USA. pfidel@lsumc.edu
- Until recently, Candida glabrata was considered a relatively nonpathogenic commensal fungal organism of human mucosal tissues. However, with the increased use of immunosuppressive agents, mucosal and systemic infections caused by C. glabrata have increased significantly, especially in the human immunodeficiency virus-
- Micronuclei formation with chromosome breaks and gene amplification caused by Vpr, an accessory gene of human immunodeficiency virus.
- Cancer Res. 1999 May 15;59(10):2259-64. Unique Identifier : AIDSLINE MED/99274522
- Shimura M; Onozuka Y; Yamaguchi T; Hatake K; Takaku F; Ishizaka Y; Department of Intractable Diseases, International Medical Center; of Japan, Tokyo.
- Vpr, an accessory gene of human immunodeficiency virus, induces cell cycle abnormality by accumulating cells at the G2-M phase. We reported recently that Vpr caused both micronuclei formation and aneuploidy. Here, we show that Vpr also induced chromosome breaks and gene amplification. Expression of Vpr induced more th
- A novel animal model for hemangiomas: inhibition of hemangioma development by the angiogenesis inhibitor TNP-470.
- Unique Identifier : AIDSLINE MED/99274544
- Liekens S; Verbeken E; Vandeputte M; De Clercq E; Neyts J
- Hemangiomas represent the most frequent tumors of infancy. However, the pathogenesis of these tumors is still largely unknown, and current treatment of juvenile hemangiomas remains unsatisfactory. Here we present a novel animal model to study proliferating hemangiomas and to evaluate the effect of angiostatic compound
- Rapid quantification of indinavir in human plasma by high-performance liquid chromatography with ultraviolet detection.
- J Chromatogr B Biomed Sci Appl. 1999 Jan 22;721(2):239-47. Unique Identifier : AIDSLINE MED/99160061
- Foisy ML; Sommadossi JP; Department of Pharmacology and Toxicology, University of Alabama; at Birmingham, 35294-0019, USA.
- A rapid, sensitive and specific high-performance liquid chromatography (HPLC) procedure for the quantification of indinavir , a potent human immunodeficiency virus (HIV) protease inhibitor, in human plasma is described. Following C18 solid-phase extrac
- The unique properties of dipeptidyl-peptidase IV (DPP IV / CD26) and the therapeutic potential of DPP IV inhibitors.
- Curr Med Chem. 1999 Apr;6(4):311-27. Unique Identifier : AIDSLINE MED/99203745
- Augustyns K; Bal G; Thonus G; Belyaev A; Zhang XM; Bollaert W; Lambeir AM; Durinx C; Goossens F; Haemers A; Department of Pharmaceutical Chemistry, University of Antwerp; (UIA), Universiteitsplein 1, Antwerpen, B-2610, Belgium.; augustyn@uia.ua.ac.be
- This review deals with the properties and functions of dipeptidyl peptidase IV (DPP IV, EC 3.4.14.5). This membrane anchored ecto-protease has been identified as the leukocyte antigen CD26. The following aspects of DPP IV/CD26 will be discussed : the structure of DPP IV and the new family of serine proteases to which
- The emerging needs of persons living with haemophilia and HIV/AIDS in British Columbia.
- Haemophilia. 1999 Jan;5(1):1-8. Unique Identifier : AIDSLINE MED/99234394
- Taylor G; Hemophilia Program, Vancouver Hospital and Health Sciences; Centre, Mary Pack Arthritis Centre Site, 895 West 10th Avenue,; Vancouver, BC V5Z 1L7, Canada. Greg_Taylor@tasvan.arth.gov.bc.ca
- The Haemophilia Programme Enhancement Project (HPEP) was initiated in 1991 to assist Haemophilia Programme staff meet the increasing and complex needs of persons living with haemophilia and HIV/AIDS. A review of the HPEP in 1997 revealed that the needs of this population have changed due to the advances in medical tre
- Hepatitis C viral load, genotype and histological severity in patients with bleeding disorders.
- Haemophilia. 1999 Jan;5(1):49-55. Unique Identifier : AIDSLINE MED/99234400
- Ahmed MM; Mutimer DJ; Martin B; Elias E; Wilde JT; Liver Unit, Queen Elizabeth Hospital, Birmingham, UK.
- We report the relationship between hepatitis C virus (HCV) titre, liver histology and HCV genotype in patients with bleeding disorders. One hundred and thirty-two RIBA-2-positive patients, including 56 who were also HIV positive, were identified at our centre. Fifty of these patients, including nine who were HIV infec
- Health status and satisfaction of asymptomatic HIV-positive haemophiliacs in Kyushu, Japan.
- Haemophilia. 1999 Jan;5(1):56-62. Unique Identifier : AIDSLINE MED/99234401
- Tanaka S; Hachisuka K; Okazaki T; Shirahata A; Ogata H; Department of Rehabilitation Medicine, University of Occupational; and Environmental Health, Yahatanishi, Kitakyushu, Japan.
- The purpose of this study was to elucidate the effects of human immunodeficiency virus (HIV) on haemophiliacs with physical functional disabilities induced by haemophilia in Kyushu, Japan . The subjects were 38 adult haemophiliacs who were selected from 129 patients registered with t
- Human recombinant DNA-derived antihaemophilic factor (factor VIII) in the treatment of haemophilia A: conclusions of a 5-year study of home therapy. The KOGENATE Study Group.
- Haemophilia. 1999 Jan;5(1):9-16. Unique Identifier : AIDSLINE MED/99234395
- Seremetis S; Lusher JM; Abildgaard CF; Kasper CK; Allred R; Hurst D; Department of Medicine, Mt. Sinai School of Medicine, New York,; NY, USA.
- Fifty-eight previously treated haemophilic subjects were treated exclusively with the recombinant FVIII (rFVIII-KOGENATE) produced by Bayer Corporation (Berkeley, CA) in an international multicentre prospective study of more than 5 years duration. Fifty-four of the 58 had severe haemophilia (
- The validity of medical history, classic symptoms, and chest radiographs in predicting pulmonary tuberculosis: derivation of a pulmonary tuberculosis prediction model.
- Chest. 1999 May;115(5):1248-53. Unique Identifier : AIDSLINE MED/99265304
- Tattevin P; Casalino E; Fleury L; Egmann G; Ruel M; Bouvet E; Clinique de Reanimation des Maladies Infectieuses, Hopital; Bichat-Claude Bernard, Paris, France.
- STUDY OBJECTIVE: To improve the respiratory isolation policy for patients with suspected pulmonary tuberculosis (TB). DESIGN: Prospective, descriptive, French multicenter study. SETTING: Emergence of nosocomial outbreaks of TB. PATIENTS: All consecutive patients admitted with suspicion of pulmonary TB. MEASUREMENTS AN
- Epidemiology of Streptococcus pneumoniae infections at the Edinburgh City Hospital: 1980-95.
- Epidemiol Infect. 1999 Apr;122(2):251-7. Unique Identifier : AIDSLINE MED/99281920
- Kalima P; Emmanuel FX; Riordan T; Department of Medical Microbiology, University of Edinburgh, UK.
- We present data on pneumococcal isolates collected from deep and superficial sites over a 16-year period at the Edinburgh City Hospital. The 10 most frequent serotypes overall were 6, 19, 11, 9, 3, 14, 1, 15 and 18 in children and 19, 23, 6, 6, 9, 11 3, 15, 14, 22 and 4 in adults. Over 88% (2588/2932, 88.3%) of these
- Needlestick and sharps injuries among health-care workers in Taiwan.
- Epidemiol Infect. 1999 Apr;122(2):259-65. Unique Identifier : AIDSLINE MED/99281921
- Guo YL; Shiao J; Chuang YC; Huang KY; Environmental and Occupational Health, and Center for; Occupational Health, National Cheng Kung University Medical; College, Tainan, Taiwan.
- Sharps injuries are a major cause of transmission of hepatitis B and C viruses and human immunodeficiency virus in health-care workers. To determine the yearly incidence and causes of sharps injuries in health-care workers in Taiwan
- Non-participation bias in unlinked anonymous HIV-prevalence surveys in England and Wales.
- Epidemiol Infect. 1999 Apr;122(2):267-72. Unique Identifier : AIDSLINE MED/99281922
- Duong T; Ades AE; Rogers P; Nicoll A; Department of Epidemiology and Public Health, Institute of Child; Health, London.
- The objective was to assess the potential bias in unlinked anonymous HIV-seroprevalence surveys from objections to specimens being included. Objection rates in seroprevalence surveys were examined. Statistically large clusters of objections were considered to be the result of health care worker behaviour, and were dis
- Determinants of antibodies to Cryptosporidium infection among gay and bisexual men with HIV infection.
- Epidemiol Infect. 1999 Apr;122(2):291-7. Unique Identifier : AIDSLINE MED/99281926
- Caputo C; Forbes A; Frost F; Sinclair MI; Kunde TR; Hoy JF; Fairley CK; Department of Epidemiology and Preventive Medicine, Monash; University, The Alfred Hospital, Victoria, Australia.
- A cross-sectional serosurvey for markers of prior Cryptosporidium infection was conducted among homosexual or bisexual males infected with human immunodeficiency virus (HIV); of 262 individuals approached, 236 (90%) agreed to participate. Serological response to two Cryptosporidium antigens was measured using a Wester
- Binding of oligopyrimidines to the RNA hairpin responsible for the ribosome gag-pol frameshift in HIV-1.
- FEBS Lett. 1999 Apr 23;449(2-3):169-74. Unique Identifier : AIDSLINE MED/99268447
- Aupeix K; Le Tinevez R; Toulme JJ; INSERM U386, IFR Pathologies Infectieuses, Universite Victor; Segalen, Bordeaux, France.
- The 12 bp stem of the RNA hairpin responsible for the gag-pol frameshifting of the ribosomes during translation of the polycistronic HIV-1 mRNA has a pyrimidine-rich 5 strand and, consequently, a purine-rich 3 strand. Electrophoretic mobility shift assays have shown that DNA oligopyrimidines, 12 and 20 nucleotides l
- Towards immunotherapy of pancreatic cancer.
- Gut. 1999 Jun;44(6):767-9. Unique Identifier : AIDSLINE MED/99257279
- McKenzie IF; Apostolopoulos V; The Austin Research Institute Studley Rd Heidelberg, VIC 3084; Australia Email: i.mckenzie@ari.unimelb.edu.au
- Verrucous carcinoma of the vulva in a patient infected with the human immunodeficiency virus.
- Gynecol Oncol. 1999 May;73(2):315-8. Unique Identifier : AIDSLINE MED/99263486
- Massad LS; Ahuja J; Bitterman P; Division of Gynecologic Oncology, Cook County Hospital and Rush; Medical College, Chicago, Illinois 60612, USA.
- Verrucous carcinomas of the vulva are rare and have not been reported in women infected with the human immunodeficiency virus. We present such a case in a 32-year-old woman characterized by bladder involvement that failed therapy with 13-cis-retinoic acid and interferon-alpha and required anterior exenteration. Copyri
- Influence of HIV-infection on the Karnofsky score and general social functioning in patients with hemophilia.
- Haemostasis. 1998 Mar-Apr;28(2):106-10. Unique Identifier : AIDSLINE MED/99189230
- Wenzel T; Pindur G; Morsdorf S; Giacchi J; Division of Social Psychiatry and Epidemiology, Department of; Psychiatry, University Hospital, Vienna, Austria.; 100410.2766@compuserve.com
- Quality of live, defined by different models, has become a major focus of research in chronic disorders. Patients with hemophilia have been found to suffer seriously from the impact of HIV infection. To compare the impact of HIV infection on HIV-positive and HIV-negative patients, we evaluated a group of 60 patients,
- Inquiries on intraspousal transmission of hepatitis C virus: benefits and limitations of genome sequencing and phylogenetic analysis.
- Forensic Sci Int. 1999 Mar 15;100(1-2):69-76. Unique Identifier : AIDSLINE MED/99285262
- Ross RS; Viazov S; Varenholz C; Roggendorf M; National Reference Centre for Hepatitis C, Institute of Virology,; Essen, Germany. stefan.ross@uni-essen.de
- During recent years, courts had to decide in some notable cases whether or not defendants infected the plaintiffs with HIV. Lawsuits on the transmission of other viral pathogens up to now have hardly become known. We report here on the use of genome sequencing and phylogenetic analysis to investigate possible intraspo
- Kikuchi lymphadenitis and AIDS [letter]
- Histopathology. 1999 Mar;34(3):273. Unique Identifier : AIDSLINE MED/99231923
- Ereno C
- Increasing prevalence of HIV-2 and dual HIV-1-2 infections among high risk group hospital admitted patients in Mumbai (Bombay).
- Indian J Med Sci. 1998 Nov;52(11):479-84. Unique Identifier : AIDSLINE MED/99234916
- Kamat HA; Banker DD; Koppikar GV; Department of Pathology, Sir Hurkisondas Nurrotumdas Hospital,; Mumbai.
- Between 1993 and 1996, we carried out a serological screening for differentially identifying HIV-1 and HIV-2 infections among the high risk group persons admitted in the various wards of BYL Nair Hospital, Mumbai, using the ImmunoComb kit. This study indicates that although HIV-1 is the predominant virus prevalent in
- Cell-mediated immunity needed for TB vaccine [news]
- Indian J Med Sci. 1998 Nov;52(11):521-2. Unique Identifier : AIDSLINE MED/99234921
- HIV seroprevalence in disseminated tuberculosis and chronic diarrhea.
- Indian Pediatr. 1998 Sep;35(9):883-7. Unique Identifier : AIDSLINE MED/99232243
- Merchant RH; Shroff RC; Bai Jerbai Wadia Hospital for Children, Mumbai, India.
- The hepatitis B pX protein promotes dimerization and DNA binding of cellular basic region/leucine zipper proteins by targeting the conserved basic region.
- J Biol Chem. 1999 May 14;274(20):13970-7. Unique Identifier : AIDSLINE MED/99253950
- Perini G; Oetjen E; Green MR; Howard Hughes Medical Institute, Program in Molecular Medicine,; University of Massachusetts Medical Center, Worcester,; Massachusetts 01605, USA.
- The hepatitis B virus pX protein is a potent transcriptional activator of viral and cellular genes whose mechanism of action is poorly understood. Here we show that pX dramatically stimulates in vitro DNA binding of a variety of cellular proteins that contain basic region/leucine zipper (bZIP) DNA binding domains. The
- Insulin-like growth factor-II/mannose 6 phosphate receptors facilitate the matrix effects of latent transforming growth factor-beta1 released from genetically modified keratinocytes in a fibroblast/keratinocyte co-culture system.
- J Cell Physiol. 1999 Jul;180(1):61-70. Unique Identifier : AIDSLINE MED/99288864
- Ghahary A; Tredget EE; Shen Q; Department of Surgery, University of Alberta, Edmonton, Canada.
- This study was conducted to explore the mechanism of activation of transforming growth factor-beta1 (TGF-beta1) which is critical to its role in many physiological and pathological conditions. To date, almost all reports concerning TGF-beta1 activation delineated that release of mature TGF-beta1 from latency associate
- The pharmacokinetics and safety profile of oral ganciclovir combined with zalcitabine or stavudine in asymptomatic HIV- and CMV-seropositive patients.
- J Clin Pharmacol. 1999 May;39(5):505-12. Unique Identifier : AIDSLINE MED/99250858
- Jung D; AbdelHameed MH; Teitelbaum P; Dorr A; Griffy K; Roche Global Development, Palo Alto, California, USA.
- Two open-label, randomized, multiple-dose, three-way crossover studies were performed to assess the pharmacokinetics and safety of oral ganciclovir 1000 mg q8h in asymptomatic patients seropositive for human immunodeficiency virus and cytomegalovirus . Ganciclovir was administered a
- The association of opportunistic infections with the occurrence of trimethoprim/sulfamethoxazole hypersensitivity in patients infected with human immunodeficiency virus.
- J Clin Pharmacol. 1999 May;39(5):533-7. Unique Identifier : AIDSLINE MED/99250861
- Lehmann DF; Liu A; Newman N; Blair DC; Department of Medicine, School of Medicine, SUNY Health Science; Center at Syracuse, New York 13210, USA.
- Hypersensitivity from trimethoprim/sulfamethoxazole (TMP/SMX) has been linked to a reactive nitroso intermediate from sulfamethoxazole metabolism, which may be altered in patients with human immunodeficiency virus (HIV) infection. The authors determined the clinical factors that are associated with TMP/SMX hypersensit
- Neuroinvasiveness of pseudorabies virus injected intracerebrally is dependent on viral concentration and terminal field density.
- J Comp Neurol. 1999 May 10;407(3):438-52. Unique Identifier : AIDSLINE MED/99251941
- Card JP; Enquist LW; Moore RY; Department of Neuroscience, University of Pittsburgh,; Pennsylvania 15260, USA. card@bns.pitt.edu
- Pseudorabies virus (PRV), a neurotropic swine alpha herpesvirus, has been used extensively for transneuronal analysis ofmultisynaptic circuitry after peripheral injection. In the present analysis, we examined the influence of viral concentration and neuronal architecture on the invasiveness, replication, and transynap
- Critique of research review of attitudes to HIV/AIDS.
- J Adv Nurs. 1999 Mar;29(3):770-1. Unique Identifier : AIDSLINE MED/99225201
- Bennett JA; The City of New York Department of Health, Office of Nursing and; Quality Improvement, New York 10013, USA.
- Ethnic differences in body image attitudes and perceptions among women infected with human immunodeficiency virus.
- J Am Diet Assoc. 1999 Jun;99(6):735-7. Unique Identifier : AIDSLINE MED/99289890
- Clark RA; Niccolai L; Kissinger PJ; Peterson Y; Bouvier V; HIV Outpatient Program, New Orleans, LA 70112, USA.
- Unopposed production of granulocyte-macrophage colony-stimulating factor by tumors inhibits CD8+ T cell responses by dysregulating antigen-presenting cell maturation.
- J Immunol. 1999 May 15;162(10):5728-37. Unique Identifier : AIDSLINE MED/99248147
- Bronte V; Chappell DB; Apolloni E; Cabrelle A; Wang M; Hwu P; Restifo NP; Department of Oncology and Surgical Sciences, Padua, Italy.
- Tumor cells gene-modified to produce GM-CSF potently stimulate antitumor immune responses, in part, by causing the growth and differentiation of dendritic cells (DC). However, GM-CSF-modified tumor cells must be gamma-irradiated or they will grow progressively, killing the host. We observed that 23 of 75 (31%) human t
- Limiting TCR expression leads to quantitative but not qualitative changes in thymic selection.
- J Immunol. 1999 May 15;162(10):5764-74. Unique Identifier : AIDSLINE MED/99248151
- Dave VP; Allman D; Wiest DL; Kappes DJ; Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
- Thymic selection is controlled in part by the avidity of the interaction between thymocytes and APCs. In agreement, the selective outcome can be modulated by altering the expression levels of selecting ligands on APCs. Here we test the converse proposition, i. e., whether changing TCR levels on thymocytes can alter th
- Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses.
- J Immunol. 1999 May 15;162(10):5784-91. Unique Identifier : AIDSLINE MED/99248153
- Khattri R; Auger JA; Griffin MD; Sharpe AH; Bluestone JA; Committee on Immunology, Ben May Institute for Cancer Research,; Department of Pathology, University of Chicago, Chicago, IL; 60637, USA.
- Mice lacking CTLA-4 die at an age of 2-3 wk due to massive lymphoproliferation, leading to lymphocytic infiltration and destruction of major organs. The onset of the lymphoproliferative disease can be delayed by treatment with murine CTLA4Ig (mCTLA4Ig), starting day 12 after birth. In this study, we have characterized
- The absence of IL-6 does not affect Th2 cell development in vivo, but does lead to impaired proliferation, IL-2 receptor expression, and B cell responses.
- J Immunol. 1999 May 15;162(10):5829-37. Unique Identifier : AIDSLINE MED/99248159
- La Flamme AC; Pearce EJ; Department of Microbiology and Immunology, College of Veterinary; Medicine, Cornell University, Ithaca, NY, 14853, USA.
- The role of IL-6 in Th2 cell differentiation and response development after the injection of eggs from Schistosoma mansoni was investigated using wild-type (WT) and IL-6-/- mice. IL-6 was induced in the lymph nodes (LN) of WT mice within 24 h of egg injection, and IL-4 production by WT LN cells and CD4 T cells isolate
- Tumor antigens are constitutively presented in the draining lymph nodes.
- J Immunol. 1999 May 15;162(10):5838-45. Unique Identifier : AIDSLINE MED/99248160
- Marzo AL; Lake RA; Lo D; Sherman L; McWilliam A; Nelson D; Robinson BW; Scott B; University Department of Medicine, Queen Elizabeth II Medical; Center, Nedlands, Western Australia, Australia.
- Tumor growth is rarely associated with a strong specific CTL response, suggesting that the immune system is ignorant of the presence of tumor because the Ags are not readily available to or are sequestered from potential effector cells. We studied the in vivo activation of naive TCR transgenic hemagglutinin (HA)-speci
- Intraepithelial lymphocytes traffic to the intestine and enhance resistance to Toxoplasma gondii oral infection.
- J Immunol. 1999 May 15;162(10):5846-52. Unique Identifier : AIDSLINE MED/99248161
- Buzoni-Gatel D; Debbabi H; Moretto M; Dimier-Poisson IH; Lepage AC; Bout DT; Kasper LH; Laboratoire Associe Institut National de la Recherche; Agronomique d'Immunologie Parasitaire, Faculte de Pharmacie,; Tours, France. buzoni@univ-tours.fr
- Toxoplasma gondii Ag-primed intraepithelial lymphocytes (IEL) from the mouse intestine have been shown to be protective against an lethal parasite challenge when adoptively transferred into recipient mice. In the present study, we observed that Ag-primed IEL traffic to the intestine of naive mice following i.v. admini
- T21/DP107, A synthetic leucine zipper-like domain of the HIV-1 envelope gp41, attracts and activates human phagocytes by using G-protein-coupled formyl peptide receptors.
- J Immunol. 1999 May 15;162(10):5924-30. Unique Identifier : AIDSLINE MED/99248171
- Su SB; Gao Jl; Gong Wh; Dunlop NM; Murphy PM; Oppenheim JJ; Wang JM; Laboratory of Molecular Immunoregulation, Division of Basic; Sciences; Intramural Research Support Program, Science; Applications International Corporation-Frederick, NCI-Frederick; Cancer Research and Development Center, MD 21702, USA.
- A leucine zipper-like domain, T21/DP107, located in the amino terminus of the ectodomain of gp41, is crucial to the formation of fusogenic configuration of the HIV-1 envelope protein gp41. We report that the synthetic T21/DP107 segment is a potent stimulant of migration and calcium mobilization in human monocytes and
- USF/c-Myc enhances, while Yin-Yang 1 suppresses, the promoter activity of CXCR4, a coreceptor for HIV-1 entry.
- J Immunol. 1999 May 15;162(10):5986-92. Unique Identifier : AIDSLINE MED/99248179
- Moriuchi M; Moriuchi H; Margolis DM; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA. Baltimore, MD 21201, USA.
- Transcription factors USF1 and USF2 up-regulate gene expression (i.e. , HIV-1 long terminal repeats) via interaction with an E box on their target promoters, which is also a binding site for c-Myc. The c-Myc oncoprotein is important in control of cellular proliferation and differentiation, while Yin-Yang 1 (YY1) has b
- Signaling through the lymphotoxin-beta receptor stimulates HIV-1 replication alone and in cooperation with soluble or membrane-bound TNF-alpha.
- J Immunol. 1999 May 15;162(10):6016-23. Unique Identifier : AIDSLINE MED/99248183
- Marshall WL; Brinkman BM; Ambrose CM; Pesavento PA; Uglialoro AM; Teng E; Finberg RW; Browning JL; Goldfeld AE; Center for Blood Research and Division of Adult Oncology,; Dana-Farber Cancer Institute, Boston, MA 02115, USA.
- The level of ongoing HIV-1 replication within an individual is critical to HIV-1 pathogenesis. Among host immune factors, the cytokine TNF-alpha has previously been shown to increase HIV-1 replication in various monocyte and T cell model systems. Here, we demonstrate that signaling through the TNF receptor family memb
- The substance P receptor is necessary for a normal granulomatous response in murine schistosomiasis mansoni.
- J Immunol. 1999 May 15;162(10):6080-5. Unique Identifier : AIDSLINE MED/99248191
- Blum AM; Metwali A; Kim-Miller M; Li J; Qadir K; Elliott DE; Lu B; Fabry Z; Gerard N; Weinstock JV; Division of Gastroenterology-Hepatology, Department of Internal; Medicine, University of Iowa, Iowa City, IA 52242, USA.
- Immune cells within the granulomas of murine schistosomiasis mansoni make the neuropeptide substance P (SP) and express neurokine 1 receptor, which is the specific receptor for substance P (SPr). It was determined if mice with deletion of the SPr (SPr-/-) would develop a normal granulomatous response to schistosome ov
- The surface protein superfamily of Trypanosoma cruzi stimulates a polarized Th1 response that becomes anergic.
- J Immunol. 1999 May 15;162(10):6092-9. Unique Identifier : AIDSLINE MED/99248193
- Millar AE; Wleklinski-Lee M; Kahn SJ; Department of Pediatrics and Pathobiology, University of; Washington, Seattle, WA 98195, USA.
- Trypanosoma cruzi is an obligate intracellular parasite that chronically infects mammals. Extracellular mammalian stage trypomastigotes simultaneously express and release multiple members of the parasite s surface protein superfamily; these extracellular proteins should stimulate MHC class II-restricted CD4 T cells. T
- IL-4- and IL-4 receptor-deficient BALB/c mice reveal differences in susceptibility to Leishmania major parasite substrains.
- J Immunol. 1999 May 15;162(10):6132-40. Unique Identifier : AIDSLINE MED/99248198
- Noben-Trauth N; Paul WE; Sacks DL; Laboratories ofImmunology and Parasitology, National Institutes; of Allergy and Infectious Diseases, National Institutes of; Health, Bethesda, MD 20892, USA. mnoben@nih.gov
- Using genetically pure BALB/c mice deficient in IL-4 (IL-4-/-) or IL-4 receptor alpha-chain (IL-4Ralpha-/-), we have observed different disease outcomes to Leishmania major infection depending on the parasite substrain. Infection with L. major LV39 caused progressive, nonhealing ulcers and uncontrolled parasite growth
- IL-1 is an effective adjuvant for mucosal and systemic immune responses when coadministered with protein immunogens.
- J Immunol. 1999 May 15;162(10):6141-7. Unique Identifier : AIDSLINE MED/99248199
- Staats HF; Ennis FA Jr; Departments of Medicine and Immunology, Center for AIDS Research,; Duke University Medical Center, Durham, NC 27710, USA.; hfs@acpub.duke.edu
- Mucosal immunization with soluble protein Ag alone may induce Ag-specific tolerance, whereas mucosal immunization with Ag in the presence of a mucosal adjuvant may induce Ag-specific systemic and mucosal humoral and cell-mediated immune responses. The most widely used and studied mucosal adjuvant is cholera toxin (CT)
- Selection of HIV-specific immunogenic epitopes by screening random peptide libraries with HIV-1-positive sera.
- J Immunol. 1999 May 15;162(10):6155-61. Unique Identifier : AIDSLINE MED/99248201
- Scala G; Chen X; Liu W; Telles JN; Cohen OJ; Vaccarezza M; Igarashi T; Fauci AS; Laboratory of Immunoregulation, and Laboratory of Molecular; Microbiology, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, Maryland; 20892, USA. gscala@niaid.nih.gov
- Efforts to develop a protective HIV-1 vaccine have been hindered by difficulties in identifying epitopes capable of inducing broad neutralizing Ab responses. In fact, the high mutation rate occurring in HIV-1 envelope proteins and the complex structure of gp120 as an oligomer associated with gp41 result in a high degr
- Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils.
- J Immunol. 1999 May 15;162(10):6178-83. Unique Identifier : AIDSLINE MED/99248204
- Cohn L; Homer RJ; MacLeod H; Mohrs M; Brombacher F; Bottomly K; Sections of Pulmonary and Critical Care Medicine and; Immunobiology and Department of Pathology, Yale University School; of Medicine, New Haven, CT 06520, USA.
- Mucus hyperproduction in asthma results from airway inflammation and contributes to clinical symptoms, airway obstruction, and mortality. In human asthmatics and in animal models, excess mucus production correlates with airway eosinophilia. We previously described a system in which TCR transgenic CD4 Th2 cells generat
- Macrophage-inflammatory protein-1alpha receptor expression on normal and chronic myeloid leukemia CD34+ cells.
- J Immunol. 1999 May 15;162(10):6191-9. Unique Identifier : AIDSLINE MED/99248206
- Nicholls SE; Lucas G; Graham GJ; Russell NH; Mottram R; Whetton AD; Buckle AM; Leukemia Research Fund Cellular Development Unit, University of; Manchester Institute of Science and Technology (UMIST),; Manchester, United Kingdom.
- We have assessed expression of MIP-1alpha binding sites on the surface of CD34+ cells from normal bone marrow (NBM) and chronic myeloid leukemia (CML) peripheral blood. This study has highlighted a small subpopulation of CD34+ (15.7 +/- 6.2% in NBM and 9 +/- 4% in CML), which has specific macrophage-inflammatory prote
- Tyrphostin B42 inhibits IL-12-induced tyrosine phosphorylation and activation of Janus kinase-2 and prevents experimental allergic encephalomyelitis.
- J Immunol. 1999 May 15;162(10):6255-62. Unique Identifier : AIDSLINE MED/99248214
- Bright JJ; Du C; Sriram S; Multiple Sclerosis Research Center, Department of Neurology,; Vanderbilt University School of Medicine, Nashville, TN 37212,; USA.
- IL-12 is a macrophage-derived cytokine that induces proliferation, cytokine production, and cytotoxic activity of T and NK cells. Signaling through its receptor, IL-12 induces these cellular responses by tyrosine phosphorylation and activation of Janus kinase-2 (Jak-2), Tyk-2, Stat3, and Stat4. We have used tyrphostin
- T cell-tropic HIV gp120 mediates CD4 and CD8 cell chemotaxis through CXCR4 independent of CD4: implications for HIV pathogenesis.
- J Immunol. 1999 May 15;162(10):6263-7. Unique Identifier : AIDSLINE MED/99248215
- Iyengar S; Schwartz DH; Hildreth JE; Department of Molecular Microbiology and Immunology, School of; Hygiene Johns Hopkins University, Baltimore, MD 21205, USA.
- HIV entry is determined by one or more chemokine receptors. T cell-tropic viruses bind CXCR4, whereas macrophage-tropic viruses use CCR5 and other CCRs. Infection with CXCR4 and CCR5-tropic HIV requires initial binding to CD4, and chemotaxis induced by the CCR5-tropic envelope has been reported to be strictly dependen
- Inflammatory cytokines and HIV-1-associated neurodegeneration: oncostatin-M produced by mononuclear cells from HIV-1-infected individuals induces apoptosis of primary neurons.
- J Immunol. 1999 May 15;162(10):6268-77. Unique Identifier : AIDSLINE MED/99248216
- Ensoli F; Fiorelli V; DeCristofaro M; Santini Muratori D; Novi A; Vannelli B; Thiele CJ; Luzi G; Aiuti F; Department of Allergy and Clinical Immunology, University of Rome; "La Sapienza," Rome, Italy. ensolifior@axrma.uniromal.it
- Neurologic abnormalities are common in HIV-1-infected patients and often represent the dominant clinical manifestation of pediatric AIDS. The neurological dysfunction has been directly related to CNS invasion by HIV-1 that is principally, if not exclusively, supported by blood-derived monocytes/macrophages and lymphoc
- The beta2-adrenergic agonist salbutamol is a potent suppressor of established collagen-induced arthritis: mechanisms of action.
- J Immunol. 1999 May 15;162(10):6278-83. Unique Identifier : AIDSLINE MED/99248217
- Malfait AM; Malik AS; Marinova-Mutafchieva L; Butler DM; Maini RN; Feldmann M; Kennedy Institute of Rheumatology, Hammersmith, London, United; Kingdom.
- The therapeutic potential of salbutamol, a beta2-adrenergic agonist, was explored in collagen-induced arthritis. This study was based on a report that salbutamol, by elevating intracellular cAMP, inhibits IL-12 production by macrophages and dendritic cells, thus preventing Th1 development. Ten-week-old male DBA/1 mice
- Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides.
- J Immunol. 1999 May 15;162(10):6284-93. Unique Identifier : AIDSLINE MED/99248218
- Sur S; Wild JS; Choudhury BK; Sur N; Alam R; Klinman DM; Division of Allergy and Immunology, Department of Internal; Medicine, University of Texas Medical Branch, Galveston, TX; 77555, USA. Sasur@utmb.edu
- Asthma is an inflammatory disease of the airways that is induced by Th2 cytokines and inhibited by Th1 cytokines. Despite a steady increase in the incidence, morbidity, and mortality from asthma, no current treatment can reduce or prevent asthma for a prolonged period. We examined the ability of unmethylated CpG oligo
- Cutting edge: clonally restricted production of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3 mRNA by human immune cells and Th1/Th2-polarized expression of their receptors.
- J Immunol. 1999 Jun 1;162(11):6303-6. Unique Identifier : AIDSLINE MED/99282907
- Besser M; Wank R; Institute of Immunology, University of Munich, Munich, Germany.
- Neurotrophins, such as neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF), are potent regulators of neuronal functions. Here we show that human immune cells also produce NT-3 mRNA, secrete BDNF, and express their specific receptors trkB and trkC. The truncated trkB receptor, usually expressed in sensor
- Cross-linking of membrane CD43 mediates dendritic cell maturation.
- J Immunol. 1999 Jun 1;162(11):6331-6. Unique Identifier : AIDSLINE MED/99282912
- Corinti S; Fanales-Belasio E; Albanesi C; Cavani A; Angelisova P; Girolomoni G; Laboratory of Immunology, Istituto Dermopatico dell'Immacolata,; IRCCS, Rome, Italy.
- CD43/leukosialin is a major sialoglycoprotein of the dendritic cell (DC) surface, which can regulate cell adhesion and has the potential to mediate cell activation signals. Monocyte-derived DC transiently incubated with the anti-CD43 mAb, MEM-59, or with F(ab )2 fragments, but not with monovalent Fab fragments or cont
- Evidence for Fas-dependent and Fas-independent mechanisms in the pathogenesis of experimental autoimmune encephalomyelitis.
- J Immunol. 1999 Jun 1;162(11):6392-400. Unique Identifier : AIDSLINE MED/99282920
- Dittel BN; Merchant RM; Janeway CA Jr; Section of Immunobiology, Yale University School of Medicine,; Howard Hughes Medical Institute, New Haven, CT 06520, USA.; bonnie.dittel@yale.edu
- To determine whether Fas or Fas ligand (FasL) plays a role in susceptibility to experimental autoimmune encephalomyelitis (EAE), we bred a TCR transgenic mouse specific for the Ac1-11 peptide of myelin basic protein to mice with inactivating mutations in Fas (lpr) or FasL (gld). Disease induction by peptide immunizati
- Effective stimulation for IL-12 p35 mRNA accumulation and bioactive IL-12 production of antigen-presenting cells interacted with Th cells.
- J Immunol. 1999 Jun 1;162(11):6433-41. Unique Identifier : AIDSLINE MED/99282925
- Yamane H; Kato T; Nariuchi H; Department of Allergology, Institute of Medical Science,; University of Tokyo, Japan.
- Bioactive IL-12 is composed of two subunits, p35 and p40. In the APC-Th cell interaction, p40 mRNA accumulation in APC was shown to be up-regulated by stimulation with CD40 ligand (CD40L) on Th cells. However, the CD40-CD40L interaction scarcely induced p35 mRNA accumulation in APC. In the present experiments, p35 mRN
- A critical role for antigen-specific Th1 cells in acute liver injury in mice.
- J Immunol. 1999 Jun 1;162(11):6503-9. Unique Identifier : AIDSLINE MED/99282933
- Nishimura T; Ohta A; Section of Genetic Engineering, Research Center for Genetic; Engineering and Cell Transplantation, Department of Immunology,; Tokai University School of Medicine, Isehara, Japan.; tak24@is.icc.u-tokai.ac.jp
- A novel liver injury model was established in mice by targeting of OVA-containing liposomes into the liver, followed by adoptive transfer of OVA-specific Th1 cells. Combined treatment of mice with OVA-containing liposomes and Th1 cell transfer caused an increase in serum transaminase activity that was paralleled with
- Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice.
- J Immunol. 1999 Jun 1;162(11):6641-9. Unique Identifier : AIDSLINE GENBANK/AF133085
- Schon MP; Arya A; Murphy EA; Adams CM; Strauch UG; Agace WW; Marsal J; Donohue JP; Her H; Beier DR; Olson S; Lefrancois L; Brenner MB; Grusby MJ; Parker CM; Division of Rheumatology, Immunology, and Allergy, Brigham and; Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
- The mucosal lymphocyte integrin alpha E(CD103)beta 7 is thought to be important for intraepithelial lymphocyte (IEL) localization or function. We cloned the murine integrin gene encoding alpha E, localized it to chromosome 11, and generated integrin alpha E-deficient mice. In alpha E-/- mice, intestinal and vaginal IE
- CD40-CD40 ligand interaction is central to cell-mediated immunity against Toxoplasma gondii: patients with hyper IgM syndrome have a defective type 1 immune response that can be restored by soluble CD40 ligand trimer.
- J Immunol. 1999 Jun 1;162(11):6690-700. Unique Identifier : AIDSLINE MED/99282955
- Subauste CS; Wessendarp M; Sorensen RU; Leiva LE; Division of Infectious Diseases, University of Cincinnati College; of Medicine, OH 46267, USA. carlos.subauste@uc.edu
- Cell-mediated immunity that results in IL-12/IFN-gamma production is essential to control infections by intracellular organisms. Studies in animal models revealed contrasting results in regard to the importance of CD40-CD40 ligand (CD40L) signaling for induction of a type 1 cytokine response against these pathogens. W
- IL-12 delivery from recombinant vaccinia virus attenuates the vector and enhances the cellular immune response against HIV-1 Env in a dose-dependent manner.
- J Immunol. 1999 Jun 1;162(11):6724-33. Unique Identifier : AIDSLINE MED/99282959
- Gherardi MM; Ramirez JC; Rodriguez D; Rodriguez JR; Sano G; Zavala F; Esteban M; Department of Molecular and Cellular Biology, Centro Nacional de; Biotecnologia, Consejo Superior de Investigaciones Cientificas,; Campus Universidad Autonoma, Madrid, Spain.
- To develop vaccination strategies against HIV-1 infection aimed to specifically enhance the cell-mediated immunity (CMI), we have engineered vaccinia virus (VV) recombinants expressing HIV-1 Env (rVVenv) and murine IL-12 (rVVlucIL-12) genes or coexpressing both genes (rVVenvIL-12). In mice inoculated with rVVlucIL-12
- Mice lacking NK cells develop an efficient Th1 response and control cutaneous Leishmania major infection.
- J Immunol. 1999 Jun 1;162(11):6747-54. Unique Identifier : AIDSLINE MED/99282962
- Satoskar AR; Stamm LM; Zhang X; Satoskar AA; Okano M; Terhorst C; David JR; Wang B; Department of Immunology and Infectious Diseases, Harvard School; of Public Health, Boston MA 02115, USA. asatoska@hsph.harvard.edu
- NK cells are believed to play a critical role in the development of immunity against Leishmania major. We recently found that transplantation of wild-type bone marrow cells into neonatal tgepsilon 26 mice, which are deficient in T and NK cells, resulted in normal T cell development, but no or poor NK cell development.
- Mechanisms of IL-10 production in human microglia-T cell interaction.
- J Immunol. 1999 Jun 1;162(11):6819-28. Unique Identifier : AIDSLINE MED/99282971
- Chabot S; Williams G; Hamilton M; Sutherland G; Yong VW; Department of Oncology, University of Calgary, Alberta, Canada.
- IL-10, a cytokine with important anti-inflammatory properties, is generated within the CNS during neuroinflammation. The mechanism for its production is poorly understood. Since infiltrating lymphocytes come into close proximity with the macrophage-like cells of the CNS, the microglia, we have used an in vitro human m
- Induction of HLA class I-restricted CD8+ CTLs specific for the major outer membrane protein of Chlamydia trachomatis in human genital tract infections.
- J Immunol. 1999 Jun 1;162(11):6855-66. Unique Identifier : AIDSLINE MED/99282976
- Kim SK; Angevine M; Demick K; Ortiz L; Rudersdorf R; Watkins D; DeMars R; Department of Medical Microbiology and Immunology, University of; Wisconsin Medical School, Madison 53706, USA.; skim18@students.wisc.edu
- HLA class I-restricted CD8+ CTLs specific for the major outer membrane protein (MOMP) of Chlamydia trachomatis are present in the peripheral blood of humans who acquired genital tract infections with the organism. Three HLA-A2-restricted epitopes and two HLA-B51-restricted epitopes were identified in serovar E-MOMP. O
- Regulation of pulmonary T cell responses to inhaled antigen: role in Th1- and Th2-mediated inflammation.
- J Immunol. 1999 Jun 1;162(11):6867-79. Unique Identifier : AIDSLINE MED/99282977
- Lee SC; Jaffar ZH; Wan KS; Holgate ST; Roberts K; University Medicine, Southampton General Hospital, United; Kingdom.
- DO11.10 transgenic mice, expressing an OVA-specific TCR, were used to study pulmonary T cell responses to inhaled Ags. Before OVA inhalation, the activation of lung parenchymal T cells elicited both strong proliferative responses and IL-2 production. However, following
- Human breast carcinoma patients develop clonable oncofetal antigen-specific effector and regulatory T lymphocytes.
- J Immunol. 1999 Jun 1;162(11):6880-92. Unique Identifier : AIDSLINE MED/99282978
- Rohrer JW; Barsoum AL; Dyess DL; Tucker JA; Coggin JH Jr; Department of Microbiology and Immunology, University of South; Alabama College of Medicine, Mobile 36688, USA.; jrohrer@jaguar1.usouthal.edu
- Oncofetal Ag (OFA) is a 44-kDa glycoprotein expressed during early to mid-gestation fetal development and re-expressed as a surface Ag by tumor cells soon after transformation. The Ag is detectable on all types of human and rodent tumors tested, but is undetectable on normal cells. In experimental animals it is autoim
- Treatment of breast cancer with fibroblasts transfected with DNA from breast cancer cells.
- J Immunol. 1999 Jun 1;162(11):6934-41. Unique Identifier : AIDSLINE MED/99282984
- de Zoeten E; Carr-Brendel V; Markovic D; Taylor-Papadimitriou J; Cohen EP; Department of Microbiology and Immunology, University of; Illinois, Chicago 60612, USA.
- This investigation was based on the hypothesis that weakly immunogenic, breast cancer-associated Ags, the products of mutant or dysregulated genes in the malignant cells, will be expressed in a highly immunogenic form by semiallogeneic IL-2-secreting fibroblasts transfected with DNA from breast cancer cells. (Classic
- New class I and II HLA alleles strongly associated with opposite patterns of progression to AIDS.
- J Immunol. 1999 Jun 1;162(11):6942-6. Unique Identifier : AIDSLINE MED/99282985
- Hendel H; Caillat-Zucman S; Lebuanec H; Carrington M; O'Brien S; Andrieu JM; Schachter F; Zagury D; Rappaport J; Winkler C; Nelson GW; Zagury JF; Laboratoire de Physiologie Cellulaire, Universite Pierre et; Marie Curie, Paris, France.
- The genetics of resistance to infection by HIV-1 cohort consists of 200 slow and 75 rapid progressors to AIDS corresponding to the extremes of HIV disease outcome of 20,000 Caucasians of European descent. A comprehensive analysis of HLA class I and class II genes in this highly informative cohort has identified HLA al
- The spectrum of hepatobiliary disease in primary hypogammaglobulinaemia.
- J Intern Med. 1999 May;245(5):517-24. Unique Identifier : AIDSLINE MED/99290421
- Bjoro K; Haaland T; Skaug K; Froland SS; Medical Department A, National Hospital, Oslo, Norway.
- OBJECTIVE: To study the prevalence of hepatobiliary disease in a clinically and immunologically well-characterized group of 88 adult Norwegian patients with primary hypogammaglobulinaemia. SUBJECTS: Eighty-eight patients with primary hypogammaglobulinaemia were followed and signs and symptoms of liver disease were rec
- Expression of the c-myc proto-oncogene is essential for HIV-1 infection in activated T cells.
- J Exp Med. 1999 May 3;189(9):1391-8. Unique Identifier : AIDSLINE MED/99242638
- Sun Y; Clark EA; Regional Primate Research Center, University of Washington,; Seattle, Washington 98195, USA.
- We previously found that activation of primary CD4+ T cells via both the T cell antigen receptor (TCR) and CD28 is required for HIV-1 DNA to be translocated from the cytoplasm to the nucleus. Here we report that expression of c-Myc protein in CD4+ T cells is induced only after such costimulation. In addition, cyclospo
- Type I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: A novel mechanism for the antitumor effects of type I IFNs.
- J Exp Med. 1999 May 3;189(9):1451-60. Unique Identifier : AIDSLINE MED/99242644
- Kayagaki N; Yamaguchi N; Nakayama M; Eto H; Okumura K; Yagita H; Department of Immunology, Juntendo University School of Medicine,; Bunkyo-ku, Tokyo 113-8421, Japan.
- Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a proapoptotic member of the TNF family of type II membrane proteins, which constitutes one component of T cell cytotoxicity. In this study, we investigated the expression and function of TRAIL in human peripheral blood T (PBT) cells. Although fr
- Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain.
- J Exp Med. 1999 May 3;189(9):1489-96. Unique Identifier : AIDSLINE MED/99242648
- Xu XN; Laffert B; Screaton GR; Kraft M; Wolf D; Kolanus W; Mongkolsapay J; McMichael AJ; Baur AS; Medical Research Council Human Immunology Unit, Institute of; Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS,; United Kingdom.
- During HIV/SIV infection, there is widespread programmed cell death in infected and, perhaps more importantly, uninfected cells. Much of this apoptosis is mediated by Fas-Fas ligand (FasL) interactions. Previously we demonstrated in macaques that induction of FasL expression and apoptotic cell death of both CD4(+) and
- A highly pathogenic simian/human immunodeficiency virus with genetic changes in cynomolgus monkey.
- Unique Identifier : AIDSLINE GENBANK/AF082832
- Shinohara K; Sakai K; Ando S; Ami Y; Yoshino N
- Coreceptor usage of BOB/GPR15 and Bonzo/STRL33 by primary isolates of human immunodeficiency virus type 1.
- J Gen Virol. 1999 May;80 ( Pt 5):1241-51. Unique Identifier : AIDSLINE MED/99281902
- Pohlmann S; Krumbiegel M; Kirchhoff F; Institute for Clinical and Molecular Virology, University of; Erlangen-Nurnberg, Erlangen, Germany.
- Primary isolates of human and simian immunodeficiency viruses (HIV and SIV) use the chemokine receptor CCR5, in association with CD4, as coreceptor. During AIDS progression, HIV-1 and HIV-2 often adapt to use additional cofactors, particularly CXCR4. In contrast, SIV isolates do not use CXCR4, but other coreceptors su
- Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) ORF54 encodes a functional dUTPase expressed in the lytic replication cycle.
- J Gen Virol. 1999 May;80 ( Pt 5):1305-10. Unique Identifier : AIDSLINE MED/99281908
- Kremmer E; Sommer P; Holzer D; Galetsky SA; Molochkov VA; Gurtsevitch V; Winkelmann C; Lisner R; Niedobitek G; Grasser FA; GSF-Institut fur Molekulare Immunologie, Munchen, Germany.
- The complete ORF54 of the Kaposi s sarcoma-associated herpesvirus (KSHV) (human herpesvirus-8; HHV-8) was cloned and expressed in E. coli. The results show that KSHV/HHV-8 ORF54 encodes a functional dUTPase which specifically hydrolyses dUTP to dUMP. Monoclonal antibodies against the HHV-8 dUTPase detected a protein w
- Assessment of AIDS knowledge, attitudes, behaviors and occupational risk of laboratory.
- J Med Liban. 1998 Sep-Oct;46(5):285-90. Unique Identifier : AIDSLINE MED/99278880
- Jurjus AR; Faculty of Medicine, American University of Beirut, Lebanon.; ajOO@aub.edu.lb
- Crystal structure of cyanovirin-N, a potent HIV-inactivating protein, shows unexpected domain swapping.
- J Mol Biol. 1999 May 7;288(3):403-12. Unique Identifier : AIDSLINE MED/99262850
- Yang F; Bewley CA; Louis JM; Gustafson KR; Boyd MR; Gronenborn AM; Clore GM; Wlodawer A; Macromolecular Structure Laboratory, ABL-Basic Research Program,; NCI-Frederick Cancer Research and Development Center, Frederick,; MD, 21702-1201, USA.
- The crystal structure of cyanovirin-N (CV-N), a protein with potent antiviral activity, was solved at 1.5 A resolution by molecular replacement using as the search model the solution structure previously determined by NMR. The crystals belong to the space group P3221 with one monomer of CV-N in each asymmetric unit. T
- Taxing the cellular capacity for repair: human T-cell leukemia virus type 1, DNA damage, and adult T-cell leukemia [editorial; comment]
- J Natl Cancer Inst. 1999 Jun 2;91(11):903-4. Unique Identifier : AIDSLINE MED/99286096
- Kibler KV; Jeang KT
- Defective DNA repair in cells with human T-cell leukemia/bovine leukemia viruses: role of tax gene [see comments]
- J Natl Cancer Inst. 1999 Jun 2;91(11):933-42. Unique Identifier : AIDSLINE MED/99286104
- Philpott SM; Buehring GC; Program in Infectious Diseases, School of Public Health,; University of California, Berkeley 94720, USA.
- BACKGROUND: Human T-cell leukemia virus (HTLV)/bovine leukemia virus (BLV) group retroviruses, which cause hematopoietic cancers, encode a unique protein, Tax, involved in the transformation of infected cells. Our purpose was to determine whether the mechanism by which Tax protein induces transformation in HTLV- or BL
- Upper airway obstruction in an HIV-1 infected child with acute Epstein-Barr virus infection [letter]
- J Trop Pediatr. 1999 Apr;45(2):119-20. Unique Identifier : AIDSLINE MED/99273057
- Weber HC; Gie R; Cotton MF; Annandale C; Kling S; Loock K
- Caring for children orphaned by AIDS [editorial]
- J Trop Pediatr. 1999 Apr;45(2):64-5. Unique Identifier : AIDSLINE MED/99273043
- Moy R
- Human T-cell lymphotropic virus types I and II infections in mother-child pairs in Nigeria.
- J Trop Pediatr. 1999 Apr;45(2):66-70. Unique Identifier : AIDSLINE MED/99273044
- Olaleye DO; Omotade OO; Sheng Z; Adeyemo AA; Odaibo GN; Department of Virology, College of Medicine, University of; Ibadan, Nigeria.
- A community-based survey to determine the prevalence of human T-cell lymphotropic type I (HTLV-I) and type II (HTLV-II) virus infections in mothers and children in south-western Nigeria was carried out using blood samples collected in 1993. A multistage cluster, random sampling pr
- Calcium signal abnormalities in murine T lymphocytes that express the multidrug transporter P-glycoprotein.
- Mech Ageing Dev. 1999 Mar 1;107(2):165-80. Unique Identifier : AIDSLINE MED/99235451
- Witkowski JM; Miller RA; Department of Physiopathology, Medical University of Gdansk,; Poland.
- Previous work has established that aging in mice leads to an accumulation of T cells that express high levels of P-glycoprotein, a plasma membrane pump that mediates multiple drug resistance in tumor cells but whose function in normal T cells is still obscure. Pgp+ cells seem to be functionally defective: isolated fro
- [HTLV-1 induced adult T-cell leukemia. The first case now documented in Sweden]
- Lakartidningen. 1999 Apr 28;96(17):2092-5. Unique Identifier : AIDSLINE MED/99283070
- Jacobsson B; Celsing F; Andersson S; Bjorkholm M; Patologavdelningen, Karolinska laboratoriet, Stockholm.
- Serum HCV RNA titer does not predict the severity of liver damage in HCV carriers with normal aminotransferase levels.
- Liver. 1999 Apr;19(2):104-9. Unique Identifier : AIDSLINE MED/99237088
- Puoti C; Stati T; Magrini A; Liver Unit, "E. De Santis" General Hospital, Rome, Italy.
- AIMS/BACKGROUND: Many HCV RNA positive subjects with normal aminotransferase levels have significant liver damage despite normal liver biochemistry. In these patients it is not possible to discriminate between healthy carriers and subjects with chronic liver damage, unless liver biopsy is performed. The aim of this
- Successful treatment of acquired perforating dermatosis with rifampicin in an Asian patient with sclerosing cholangitis.
- Liver. 1999 Apr;19(2):160-3. Unique Identifier : AIDSLINE MED/99237096
- Skiba G; Milkiewicz P; Mutimer D; Burns DA; Marsden JR; Elias E; Liver and Hepatobiliary Unit, Queen Elizabeth Hospital,; Birmingham, UK.
- Acquired perforating dermatosis (APD) is a very rare disorder which has been described in association with systemic diseases such as diabetes mellitus, HIV infection or lymphoma. In this report we describe a patient with APD associated with sclerosing cholangitis and diabetes mellitus who was successfully treated with
- An analysis of optimal resource allocation for prevention of infection with human immunodeficiency virus (HIV) in injection drug users and non-users.
- Med Decis Making. 1999 Apr-Jun;19(2):167-79. Unique Identifier : AIDSLINE MED/99246110
- Richter A; Brandeau ML; Owens DK; Center for Economics Research, Research Triangle Institute,; Durham, NC, USA.
- Millions of dollars are spent annually to prevent infection with human immunodeficiency virus (HIV) without a thorough understanding of the most effective way to allocate these resources. The authors objective was to determine the allocation of new resources among prevention programs targeted to a population of injec
- Implicit valuation of a blood-exclusion decision.
- Med Decis Making. 1999 Apr-Jun;19(2):207-13. Unique Identifier : AIDSLINE MED/99246115
- Kaplan EH; Yale School of Management, New Haven, Connecticut 06520-8200,; USA. edward.kaplan@yale.edu
- This paper presents an implicit valuation of Israel s decision to exclude blood donations from Ethiopian immigrants. The approach adopts assumptions that deliberately overstate the public health effectiveness of this policy, for if such an analysis fails to justify exclusion on public health grounds, nothing will. Bui
- [Assessment of the effectiveness of medical instruments sterilization by electrochemically activated solutions and computer modeling of the dynamics of hospital infections]
- Med Tekh. 1999 Mar-Apr;(2):14-6. Unique Identifier : AIDSLINE MED/99267984
- Bakhir VM; Grishin VP; Panicheva SA; Toloknov VI
- The paper sets a task of evaluating the efficiency of electrochemically activated solution sterilization of medical instruments, which is tackled by the computer-aided simulation of time course of nosocomial HIV infection.
- Changes in ds/dn in the HIV-1 env gene [letter]
- Mol Biol Evol. 1999 May;16(5):711-4. Unique Identifier : AIDSLINE MED/99268144
- Nielsen R
- Prevention of varicella. Update recommendations of the Advisory Committee on Immunization Practices (ACIP).
- MMWR Morb Mortal Wkly Rep. 1999 May 28;48(RR-6):1-5. Unique Identifier : AIDSLINE MED/99292259
- In February 1999, the Advisory Committee on Immunization Practices (ACIP) expanded recommendations for varicella (chickenpox) vaccine to promote wider use of the vaccine for susceptible children and adults. The updated recommendations include establishing child care and school entry requirements, use of the vaccine fo
- Prenatal discussion of HIV testing and maternal HIV testing--14 states, 1996-1997.
- MMWR Morb Mortal Wkly Rep. 1999 May 21;48(19):401-4. Unique Identifier : AIDSLINE MED/99292258
- In July 1995, the Public Health Service recommended that health-care providers counsel all pregnant women about human immunodeficiency virus (HIV) prevention and encourage testing for HIV infection and, if indicated, initiate zidovudine therapy. To evaluate compliance with these recommendations, CDC analyzed populatio
- Cluster of HIV-positive young women--New York, 1997-1998.
- MMWR Morb Mortal Wkly Rep. 1999 May 28;48(20):413-6. Unique Identifier : AIDSLINE MED/99291752
- As of July 1997, six human immunodeficiency virus (HIV) infections in young women who reported sexual contact with the same HIV-infected man (putative index case-patient) were detected at health-service clinics in a rural county in upstate New York. During the next several months, other sexual contacts of the man were
- Trends in HIV-related sexual risk behaviors among high school students--selected U.S. cities, 1991-1997.
- MMWR Morb Mortal Wkly Rep. 1999 Jun 4;48(21):440-3. Unique Identifier : AIDSLINE MED/99299716
- Despite recent decreases in sexual risk behaviors among high school students nationwide, human immunodeficiency virus (HIV) infection was the seventh leading cause of death among persons aged 15-24 years in the United States during 1997. To determine whether the prevalence of HIV-relat
- Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans.
- Mol Cell Biol. 1999 Jun;19(6):4101-12. Unique Identifier : AIDSLINE GENBANK/AF097889
- Cruz MC; Cavallo LM; Gorlach JM; Cox G; Perfect JR; Cardenas ME; Heitman J; Departments of Genetics, Duke University Medical Center, Durham,; North Carolina 27710, USA.
- Cryptococcus neoformans is a fungal pathogen that causes meningitis in patients immunocompromised by AIDS, chemotherapy, organ transplantation, or high-dose steroids. Current antifungal drug therapies are limited and suffer from toxic side effects and drug resistance. Here, we defined the targets and mechanisms of ant
- Expression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte development.
- Mol Cell Biol. 1999 Jun;19(6):4200-8. Unique Identifier : AIDSLINE MED/99262991
- Seavitt JR; White LS; Murphy KM; Loh DY; Perlmutter RM; Thomas ML; Center for Immunology, Department of Pathology and Howard Hughes; Medical Institute, Washington University, St. Louis, Missouri; 63110, USA.
- Mice deficient in the transmembrane protein tyrosine phosphatase CD45 exhibit a block in thymocyte development. To determine whether the block in thymocyte development was due to the inability to dephosphorylate the inhibitory phosphorylation site (Y505) in p56(lck) (Lck), we generated CD45-deficient mice that express
- Antibodies against human herpesvirus 8 in black South African patients with cancer [see comments]
- N Engl J Med. 1999 Jun 17;340(24):1863-71. Unique Identifier : AIDSLINE MED/99280039
- Sitas F; Carrara H; Beral V; Newton R; Reeves G; Bull D; Jentsch U; Pacella-Norman R; Bourboulia D; Whitby D; Boshoff C; Weiss R; National Cancer Registry, Department of Anatomical Pathology,; South African Institute for Medical Research, Johannesburg.; freddys@mail.saimr.wits.ac.za
- BACKGROUND: Infection with human herpesvirus 8 (HHV-8) has been consistently linked to Kaposi s sarcoma, but its mode of transmission, association with other cancers, and interaction with the human immunodeficiency virus type 1 (HIV-1) are largely unknown. METHODS: Between January 1992 and December 1997, we interviewe
- Human herpesvirus 8 and Kaposi's sarcoma--some answers, more questions [editorial; comment]
- N Engl J Med. 1999 Jun 17;340(24):1912-3. Unique Identifier : AIDSLINE MED/99280046
- Jaffe HW; Pellett PE
- Increasing probability of mother-to-child transmission of HHV-8 with increasing maternal antibody titer for HHV-8 [letter]
- N Engl J Med. 1999 Jun 17;340(24):1923. Unique Identifier : AIDSLINE MED/99280050
- Sitas F; Newton R; Boshoff C
- An unusual cluster of cases of Castleman's disease during highly active antiretroviral therapy for AIDS [letter]
- N Engl J Med. 1999 Jun 17;340(24):1923-4. Unique Identifier : AIDSLINE MED/99280051
- Zietz C; Bogner JR; Goebel FD; Lohrs U
- Impure, maybe, but exemplary [editorial]
- Nature. 1999 May 13;399(6732):89. Unique Identifier : AIDSLINE MED/99266860
- Drug company backs Africa's war on AIDS [news]
- Nature. 1999 May 13;399(6732):96. Unique Identifier : AIDSLINE MED/99266865
- Wadman M
- US plan for consortium to seek AIDS vaccine [news]
- Nature. 1999 May 20;399(6733):192. Unique Identifier : AIDSLINE MED/99279673
- South Africa reveals plans to make AIDS a notifiable disease [news]
- Nature. 1999 May 27;399(6734):288. Unique Identifier : AIDSLINE MED/99287302
- Cherry M
- Progressive dendritic pathology in cynomolgus macaques infected with simian immunodeficiency virus.
- Neuropathol Appl Neurobiol. 1999 Feb;25(1):11-9. Unique Identifier : AIDSLINE MED/99210675
- Montgomery MM; Dean AF; Taffs F; Stott EJ; Lantos PL; Luthert PJ; Department of Pathology, University College London, UK.
- Neuronal pathology in acquired immunodeficiency syndrome (AIDS) is of interest in relation to cognitive impairment in AIDS patients and from the broader perspective of the pathogenesis of neurodegeneration. Cortical dendritic spine loss has been described in patients with AIDS and the aim of this study was to test the
- Spinal cord pathology and viral burden in homosexuals and drug users with AIDS.
- Neuropathol Appl Neurobiol. 1999 Feb;25(1):2-10. Unique Identifier : AIDSLINE MED/99210674
- Shepherd EJ; Brettle RP; Liberski PP; Aguzzi A; Ironside JW; Simmonds P; Bell JE; Department of Pathology, University of Edinburgh, Western General; Hospital, UK.
- Unless treated with effective antiretroviral therapy many AIDS patients develop a characteristic vacuolar myelopathy of the spinal cord associated with moderate clinical disability. Opinion is divided as to whether vacuolar myelopathy is causally linked to HIV myelitis. To investigate this further, spinal cord patholo
- Infantile HIV encephalopathy associated with cerebral and cerebellar telangiectases.
- Neuropathol Appl Neurobiol. 1999 Feb;25(1):72-5. Unique Identifier : AIDSLINE MED/99210682
- Luzar B; Popovic M; Cerar A; Institute of Pathology, Medical Faculty, Ljubljana, Slovenia.
- We describe a paediatric case of HIV encephalopathy associated with cerebral and cerebellar telangiectases. Although immunohistochemistry failed to show HIV in the walls of dilated blood vessels, or in their vicinity, brain capillary telangiectases might be an additional complication indirectly related to paediatric H
- Acyclovir treatment of experimentally induced herpes simplex virus encephalitis: monitoring the changes in immunologic NO synthase expression and viral load within brain tissue of SJL mice.
- Neurosci Lett. 1999 Apr 2;264(1-3):129-32. Unique Identifier : AIDSLINE MED/99251749
- Haas J; Meyding-Lamade U; Fath A; Stingele K; Storch-Hagenlocher B; Wildemann B; Department of Neurology, University of Heidelberg, Germany.; juergenhaas@med.uni-heidelberg.de
- The effect of acyclovir treatment on viral burden and the expression of immunologic nitric oxide synthase (iNOS) within brains of 42 HSV-1 F infected mice was studied by using a titration PCR assay for HSV-1 DNA and a semiquantitative RT-PCR for iNOS mRNA. iNOS mediated NO-produ
- Human T-cell leukemia virus type 1 Tax protein induces the expression of STAT1 and STAT5 genes in T-cells.
- Oncogene. 1999 Apr 29;18(17):2667-75. Unique Identifier : AIDSLINE MED/99276096
- Nakamura N; Fujii M; Tsukahara T; Arai M; Ohashi T; Wakao H; Kannagi M; Yamamoto N; Department of Microbiology, Tokyo Medical and Dental University,; Japan.
- Human T-cell leukemia virus type 1 (HTLV-1) Tax transforms normal T-cells in the presence of interleukin (IL)-2 in vitro. STAT is a family of transcription factors that play a pivotal role in cytokine-induced functions of a various type of cells. We investigated the involvement of STATs in the transformation of T-cell
- Chemokine and inflammatory cell response to hypoxia-ischemia in immature rats.
- Pediatr Res. 1999 Apr;45(4 Pt 1):500-9. Unique Identifier : AIDSLINE MED/99217791
- Bona E; Andersson AL; Blomgren K; Gilland E; Puka-Sundvall M; Gustafson K; Hagberg H; Perinatal Center, Department of Physiology and Pharmacology,; Goteborg University, Sweden.
- Hypoxia-ischemia induces an inflammatory response in the immature central nervous system that may be important for development of brain injury. Recent data implicate that chemoattractant cytokines, chemokines, are involved in the recruitment of immune cells. The aim was to study alpha- and beta-chemokines in relation
- Ethical and moral dilemmas.
- Pediatr Emerg Care. 1999 Apr;15(2):144-6. Unique Identifier : AIDSLINE MED/99235495
- Rosenberg NM; Christian CW; Knazik SR; Chabali R; Division of Emergency Services, Children's Hospital of Michigan,; Detroit, USA.
- [Therapeutic attitude to HIV infection: uncertain and variable scientific attitudes. 1998 national survey of physicians prescribing antiretroviral drugs]
- Presse Med. 1999 May 1-8;28(17):899-907. Unique Identifier : AIDSLINE MED/99288457
- Landman R; Kertenian I; Perrin V; Huard P; Moatti JP; Service des Maladies Infectieuses et Tropicales, Hopital; Bichat-Claude Bernard, Paris.
- OBJECTIVES: Analyze the attitudes of French practitioners managing HIV infected patients towards multidrug antiretroviral therapies with protease inhibitors , open issues, and the official guidelines (Dormont report). METHODS: A telephone survey was conducted in Febr
- [Muscular aspergillosis in an AIDS patient: a new case (letter)]
- Presse Med. 1999 May 1-8;28(17):914. Unique Identifier : AIDSLINE MED/99288462
- Bouree P; Lebras P
- [Mitral papillary fibroelastoma in a HIV infected patient]
- Presse Med. 1999 May 15;28(18):962-4. Unique Identifier : AIDSLINE MED/99295007
- Paraf F; Berrebi A; Chauvaud S; Fornes P; Farge D; Bruneval P; Service d'Anatomie Pathologique, Hopital Broussais, Paris.
- BACKGROUND: Papillary fibroelastoma of the endocardium is a benign cardiac tumor which may cause embolic events. CASE REPORT: We report the first case, to our knowledge, of cardiac papillary fibroelastoma which was revealed by cerebral ischemic events in a patient infected by the human immunodeficiency virus. The init
- The role of CD8+ cells, cell degeneration, and Fas ligand in insulitis after intraperitoneal transfer of NOD splenocytes.
- Pancreas. 1999 Apr;18(3):282-93. Unique Identifier : AIDSLINE MED/99221328
- Sainio-Pollanen S; Liukas A; Pollanen P; Simell O; Department of Anatomy, University of Turku, Finland.
- Cells expressing CD4, CD8, CD18, CD49d/CD29, CD44, CD54, CD80, CD86, CD106, CD11b/CD18 or DNA breaks were stained in the pancreases of female or male scid/ scid mice after adoptive transfer of lymphocytes from older than 12-week female nonobese diabetic (NOD) or Balb/c mice. After intraperitoneal adoptive transfer of
- Inducing autoimmune disease to treat cancer.
- Proc Natl Acad Sci U S A. 1999 May 11;96(10):5340-2. Unique Identifier : AIDSLINE MED/99254038
- Pardoll DM
- High- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal CD8alphaalpha and CD8alphabeta T lymphocytes.
- Proc Natl Acad Sci U S A. 1999 May 11;96(10):5628-33. Unique Identifier : AIDSLINE MED/99254092
- Levelt CN; de Jong YP; Mizoguchi E; O'Farrelly C; Bhan AK; Tonegawa S; Terhorst C; Simpson SJ; Center for Cancer Research, Massachusetts Institute of; Technology, Cambridge MA, 02139, USA.
- In this study, we compared the influence of two peptides on the selection of CD8alphaalpha and CD8alphabeta intraepithelial lymphocytes (IELs) of the intestine, which develop by a unique and partially thymus-independent process. Mice were used in which all T cells carried one transgenic T cell antigen receptor (TCR) (
- Quantitative analysis of hepatitis C virus-specific CD8(+) T cells in peripheral blood and liver using peptide-MHC tetramers.
- Proc Natl Acad Sci U S A. 1999 May 11;96(10):5692-7. Unique Identifier : AIDSLINE MED/99254103
- He XS; Rehermann B; Lopez-Labrador FX; Boisvert J; Cheung R; Mumm J; Wedemeyer H; Berenguer M; Wright TL; Davis MM; Greenberg HB; Department of Medicine, Stanford University School of Medicine,; Stanford, CA 94305, USA. xiasong@leland.stanford.edu
- It is believed that the hepatitis C virus (HCV)-specific CD8(+) cytotoxic T lymphocytes (CTLs) play a role in the development of liver cell injury and in the clearance of the virus. To develop a direct binding assay for HCV-specific CTLs, we generated two peptide-MHC tetramers by using the recombinant HLA A2.1 molecul
- A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity.
- Proc Natl Acad Sci U S A. 1999 May 11;96(10):5698-703. Unique Identifier : AIDSLINE MED/99254104
- Baba M; Nishimura O; Kanzaki N; Okamoto M; Sawada H; Iizawa Y; Shiraishi M; Aramaki Y; Okonogi K; Ogawa Y; Meguro K; Fujino M; Division of Human Retroviruses, Center for Chronic Viral; Diseases, Faculty of Medicine, Kagoshima University, Kagoshima; 890-8520, Japan.
- The beta-chemokine receptor CCR5 is considered to be an attractive target for inhibition of macrophage-tropic (CCR5-using or R5) HIV-1 replication because individuals having a nonfunctional receptor (a homozygous 32-bp deletion in the CCR5 coding region) are apparently normal but resistant to infection with R5 HIV-1.
- Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.
- Proc Natl Acad Sci U S A. 1999 May 11;96(10):5704-9. Unique Identifier : AIDSLINE MED/99254105
- Lagunoff M; Majeti R; Weiss A; Ganem D; Howard Hughes Medical Institute and Departments of Microbiology; and Immunology and of Medicine, University of California, San; Francisco, CA 94143-0414, USA.
- The Kaposi s sarcoma (KS)-associated herpesvirus is a lymphotropic virus strongly implicated in the pathogenesis of KS and several lymphoproliferative disorders. The KS-associated herpesvirus K1 gene encodes a transmembrane protein bearing a functional immunoreceptor tyrosine-based activation motif (ITAM)-like sequenc
- [Sociodemographic profile of a group of sex workers in Puerto Rico]
- P R Health Sci J. 1999 Mar;18(1):53-7. Unique Identifier : AIDSLINE MED/99275455
- Rodriguez Figueroa J; Irizarry Castro A; Alegria M; Vera M; Perez Perdomo R; Centro de Investigaciones y Evaluacion Sociomedica, Escuela; Graduada de Salud Publica, Recinto de Ciencias Medicas,; Universidad de Puerto Rico, San Juan.
- This research explored the sociodemographic characteristics, the health perceptions and the distinctive aspects of the sexual work of a group of women sexual workers (n = 311). The study interest was generating data relative to the use of injectable drugs, the prevalence of sexually transmitted diseases (STD), the pre
- [Esophageal candidiasis in AIDS patients. A clinical and microbiological study]
- Rev Cubana Med Trop. 1998;50(2):110-4. Unique Identifier : AIDSLINE MED/99279045
- Flores de Apodaca Verdura Z; Martinez Machin G; Ruiz Perez A; Fernandez Andreu CM; Mune Jimenez M; Perurena Lancha M; Instituto de Medicina Tropical, Pedro Kouri, Ciudad de La; Habana, Cuba.
- 18 AIDS patients who presented high gastrointestinal symptoms or lesions in the oral cavity suggestive of candidiasis were studied. Clinical data, specimen of the oral cavity, biopsies and esophageal brushing, as well as serum from all patients were obtained. Dysphagia was the main symptom observed in the esophageal c
- [A chromatographic analysis of the Mycobacterium tuberculosis strains isolated from an outbreak in HIV patients in Cuba]
- Rev Cubana Med Trop. 1998;50(2):120-3. Unique Identifier : AIDSLINE MED/99279047
- Mederos LM; Quinones Y; Ruiz A; Teja I; Valdivia JA; Instituto de Medicina Tropical Pedro Kouri, Ciudad de La Habana,; Cuba.
- A group of strains of Mycobacterium tuberculosis isolated from an outbreak in HIV-infected patients was studied by chromatographic techniques. A group of strains of M. Tuberculosis from symptomatic respiratory patients (SR+ 14) and patterns strains from the laboratory collection were used as a reference aimed at makin
- [The identification of Cryptococcus neoformans var. neoformans in Cuban clinical isolates]
- Rev Cubana Med Trop. 1998;50(2):167-9. Unique Identifier : AIDSLINE MED/99279055
- Fernandez Andreu CM; Martinez Machin G; Illnait Zaragozi MT; Perurena Lancha M; Gonzalez Miranda M; Instituto de Medicina Tropical Pedro Kouri, Ciudad de La Habana,; Cuba.
- 50 strains of Cryptococcus neoformans of clinical origin were studied by using the canavanine-glycine-bromothymol blue (CGB) medium. 56% of the strains were isolated from AIDS patients, and 16% belonged to patients with kidney transplantation. 90% of the samples were obtained from the samples of cerebrospinal fluid, w
- [The determination of antibodies to the human immunodeficiency virus type 1 (HIV-1) in samples of dried blood on filter paper]
- Rev Cubana Med Trop. 1998;50(2):93-5. Unique Identifier : AIDSLINE MED/99279041
- Perez Guevara MT; Rolo Gomez FM; Nibot Sanchez C; Cruz Sui O; Rodriguez O; Centro de Investigaciones Cientificas, Defensa Civil,; Laboratorio de Investigaciones del SIDA, San Jose de las Lajas,; Cuba.
- The possibility of detecting HIV-1 antibodies by an immunoblotting kit is studied in a panel of 125 known specimens of dried blood spotted on filter paper and their corresponding serum samples. No differences were observed in the patterns of bands with both types of samples or in the sensitivity and specificity, where
- [The biological characterization of HIV-1 isolated in patients with a rapid clinical evolution]
- Rev Cubana Med Trop. 1998;50(2):96-9. Unique Identifier : AIDSLINE MED/99279042
- Lobaina Barthelemy L; Dubed Echevarria M; Vilarrubia Montes de Oca OL; Navea Leyva L; Diaz Torres HM; Izquierdo Marquez M; Noa Romero E; Laboratorio de Investigaciones del SIDA, San Jose de las Lajas,; Cuba.
- The biological characteristics of 11 HIV-1 strains isolated from patients with a fast clinical evolution to AIDS were studied. The viral isolates were classified according to their replication kinetics and cell tropism. Taking into account these criteria, it was observed that 8 of the isolated strains (72.7%) were of
- [The diagnosis of new cases of HIV infection: a reversal of the trend?]
- Recenti Prog Med. 1999 Apr;90(4):202-5. Unique Identifier : AIDSLINE MED/99283129
- Manfredi R; Borderi M; Talo S; Spinosa Guzman SM; Tadolini M; Donzelli C; Beltrami C; Chiodo F; Dipartimento di Medicina Clinica Specialistica e Sperimentale,; Universita, Bologna.
- In order to assess the trend of new cases of HIV infection, spontaneous requests of HIV counseling and testing made at our outpatient Center since 1993 were retrospectively evaluated. During the considered 6-year period, 7,492 subjects had voluntary HIV testing, and 225 proved HIV-positive (3.0%). While the overall nu
- [The symptoms in HIV disease: prevalence and control (editorial)]
- Recenti Prog Med. 1999 Apr;90(4):217-21. Unique Identifier : AIDSLINE MED/99283134
- Fantoni M; Del Borgo C
- Estimating AIDS incidence and jack-knife variance from a continuous delay distribution and incomplete data.
- Stat Med. 1999 Mar 15;18(5):527-37. Unique Identifier : AIDSLINE MED/99226284
- Cui J; Department of Public Health, University of Melbourne, Carlton,; VIC, Australia. j.cui@gpph.unimelb.edu.au
- Usual methods for estimating AIDS incidences are based on the inflation of a discrete reporting delay distribution, which often results in very imprecise estimates of the incidence in the most recent past. In this paper, we propose an alternative approach to estimate the AIDS incidence by inflating a continuous report
- Intestinal T lymphocytes of different rat strains in immunotoxicity.
- Toxicol Pathol. 1999 Mar-Apr;27(2):171-9. Unique Identifier : AIDSLINE MED/99224388
- Bruder MC; Spanhaak S; Bruijntjes JP; Michielsen CP; Vos JG; Kuper CF; TNO Nutrition and Food Research Institute, Department of General; Toxicology, Zeist, The Netherlands.
- In order to study the intestinal mucosal immune cells, with emphasis on single T lymphocytes, an inventory was made of single and organized lymphocytes in the epithelium and lamina propria of the small intestines of untreated Wistar, Fischer 344, and Lewis rats. The single and organized lymphocytes were examined micro
- [Social sciences and AIDS (editorial)]
- Salud Publica Mex. 1999 Mar-Apr;41(2):83-4. Unique Identifier : AIDSLINE MED/99274978
- Bronfman M
- [Condom use by men with non-stable partners in Mexico City]
- Salud Publica Mex. 1999 Mar-Apr;41(2):85-94. Unique Identifier : AIDSLINE MED/99274979
- Nieto-Andrade B; Izazola-Licea JA; Centro de Investigacion en Salud Poblacional, Instituto Nacional; de Salud Publica, Cuernavaca, Morelos, Mexico.
- OBJECTIVE: To analyze the association between sociodemographic variables and condom use during vaginal sexual relationships with non-stable partners. MATERIAL AND METHODS: Data were taken from a household probability survey on sexual behavior in 1992-1993 in the Mexico City Metropolitan Area. Of the completed survey w
- [Characteristics of sex behavior of men in Mexico City]
- Salud Publica Mex. 1999 Mar-Apr;41(2):95-100. Unique Identifier : AIDSLINE MED/99274980
- Hernandez-Giron C; Cruz-Valdez A; Quiterio-Trenado M; Peruga A; Hernandez-Avila M; Centro de Investigacion en Salud Poblacional, Instituto Nacional; de Salud Publica, Cuernavaca, Morelos, Mexico.
- OBJECTIVE: To determine the major features of sexual behavior in men from Mexico City, such as the number of sexual partners, history of sexually transmitted disease (STD) and beliefs on AIDS. MATERIAL AND METHODS: A transversal epidemiologic study was conducted in 1995 based on multistage sampling with conglomerates.
- Endoscopic vs conventional hernia repair from an immunologic point of view.
- Surg Endosc. 1999 Apr;13(4):335-9. Unique Identifier : AIDSLINE MED/99194872
- Decker D; Lindemann C; Springer W; Low A; Hirner A; von Ruecker A; Department of Surgery, University of Bonn, Sigmund-Freud-Strasse; 25, 53105, Bonn, Germany.
- BACKGROUND: In this study we tried to estimate the local surgical trauma in patients undergoing endoscopic or conventional hernia repair via the changes in peripheral blood T cell subpopulations (i. e., T-helper 1 (TH1) and TH2 cells), recently shown to be recruited differentially to inflammatory sites. METHODS: Cells
- AIDS associated cholangiopathy.
- Trop Gastroenterol. 1998 Oct-Dec;19(4):155-6. Unique Identifier : AIDSLINE MED/99245125
- Kumar M; Murthy A; Duggal L; Sud R; Department of Gastroenterology, Sir Ganga Ram Hospital, New; Delhi.
- [Neurologic cryptococcosis: meningitis of the immunosuppressed patient]
- Tunis Med. 1999 Jan;77(1):45-9. Unique Identifier : AIDSLINE MED/99266240
- Kallel K; Mejri H; Belhadj S; Boussen N; Kilani B; Zouiten F; Ben Abid H; Zribi A; Chaker E; Laboratoire de Parasitologie-Mycologie, Hopital La Rabta.
- Expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor on B-1a cell from persistent lymphocytosis (PL) cows and lymphoma cell induced by bovine leukemia virus.
- Vet Immunol Immunopathol. 1999 Mar 29;68(1):49-59. Unique Identifier : AIDSLINE MED/99248733
- Murakami K; Inumaru S; Yokoyama T; Okada K; Sentsui H; National Institute of Animal Health, Ibaraki, Japan.; kenji.murakami@yale.edu
- The effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on B lymphocytes from persistent lymphocytosis (PL) cattle and lymphoma cells induced by bovine leukemia virus (BLV) was studied in vitro. Flow cytometric analysis showed that high levels of receptors to GM-CSF were expressed on these cell types.
- Vanadium stimulates immunological responses of chicks.
- Vet Immunol Immunopathol. 1999 Mar 29;68(1):61-71. Unique Identifier : AIDSLINE MED/99248734
- Qureshi MA; Hill CH; Heggen CL; Department of Poultry Science, North Carolina State University,; Raleigh 27695-7608, USA. m_qureshi@ncsu.edu
- In a continuation of studies on the interaction of dietary phosphorus (P) and vanadium (V) levels, studies have directed toward an examination of this interaction on the immune system of chicks. Antibody titers to sheep red blood cells (SRBC) were increased at 7 days post-inoculation (PI) by as little as 10 mg V/kg di
- Multiple control levels of cell proliferation by human T-cell leukemia virus type 1 Tax protein.
- Virology. 1999 May 10;257(2):277-84. Unique Identifier : AIDSLINE MED/99263154
- Mesnard JM; Devaux C; Laboratoire Infections Retrovirales et Signalisation Cellulaire,; CRBM-CNRS UPR 1086, Institut de Biologie, 4 Boulevard Henri IV,; Montpellier, 34060, France. mesnard@crbm.cnrs-mop.fr
- The cellular kinase binding motifs (PxxP and RR) in human immunodeficiency virus type 1 Nef protein are dispensable for producer-cell-dependent enhancement of viral entry.
- Virology. 1999 May 10;257(2):285-9. Unique Identifier : AIDSLINE MED/99263155
- Tokunaga K; Ikuta K; Adachi A; Matsuda M; Kurata T; Kojima A; Department of Pathology, National Institute of Infectious; Diseases, Tokyo, 162-8640, Japan.
- We have recently demonstrated that human immunodeficiency virus type 1 (HIV-1) Nef is required for enhancing viral infectivity by increasing the efficiency of viral entry in a producer-cell-dependent manner, suggesting the possible involvement of a cellular factor(s) in the enhancement of viral entry. Moreover, it has
- Identification of determinants of interaction between CXCR4 and gp120 of a dual-tropic HIV-1DH12 isolate.
- Virology. 1999 May 10;257(2):290-6. Unique Identifier : AIDSLINE MED/99263156
- Lee MK; Heaton J; Cho MW; NIAID, National Institutes of Health, Bethesda, Maryland; 20892-0460, USA.
- Using a panel of chimeric viruses and their chimeric envelope glycoproteins, we have previously reported that the V1/V2 or the V3 regions of a dual-tropic primary human immunodeficiency virus type 1 (HIV-1) isolate (HIV-1DH12) could individually confer CXCR4 usage when introduced into the backbone of a macrophage-trop
- Activation of the interferon-inducible (2'-5') oligoadenylate synthetase by the Epstein-Barr virus RNA, EBER-1.
- Virology. 1999 May 10;257(2):303-13. Unique Identifier : AIDSLINE MED/99263158
- Sharp TV; Raine DA; Gewert DR; Joshi B; Jagus R; Clemens MJ; Cellular and Molecular Sciences Group, St. George's Hospital; Medical School, Cranmer Terrace, London, SW17 0RE, United; Kingdom.
- The 2 -5 oligoadenylate synthetases and the protein kinase PKR are both interferon-induced, double-stranded RNA-dependent proteins that play important roles in the antiviral effects of the interferons and in cellular growth control. Both enzymes are activated by natural or synthetic dsRNAs and by single-stranded RNAs
- HTLV-I-infected T cells evade the antiproliferative action of IFN-beta.
- Virology. 1999 May 10;257(2):314-21. Unique Identifier : AIDSLINE MED/99263159
- Smith D; Buckle GJ; Hafler DA; Frank DA; Hollsberg P; Center for Neurologic Diseases, Brigham and Women's Hospital and; Harvard Medical School, Boston, Massachusetts 02115, USA.
- Human T-cell lymphotropic virus type I (HTLV-I)-infected T-cell clones enter the S-phase of the cell cycle in the absence of exogenous IL-2 . The pathway by which HTLV-I activates the host T cell may circumvent normal immunoregulatory mechanisms and thus be important fo
- Limitation of Tat-associated transcriptional processivity in HIV-infected PBMC.
- Virology. 1999 May 10;257(2):397-405. Unique Identifier : AIDSLINE MED/99263167
- Adams M; Wong C; Wang D; Romeo J; Center for Biomedical Laboratory Sciences, San Francisco State; University, 1600 Holloway Avenue, San Francisco, California; 94132, USA.
- The ability of HIV to match levels of viral mRNA to the activation state of the host cell may play a role in its ability to persist as well as to replicate. This linkage depends on the function of the viral transcriptional regulatory protein, Tat, which increases the efficiency of RNA elongation (transcriptional proce
- Studies on antibody responses following neonatal immunization with influenza hemagglutinin DNA or protein.
- Virology. 1999 May 10;257(2):406-14. Unique Identifier : AIDSLINE MED/99263168
- Pertmer TM; Robinson HL; Department of Pathology, University of Massachusetts Medical; School, Worcester, Massachusetts 01655, USA.
- Neonatal mice have immature immune systems with defects in several components of inflammatory, innate, and specific immune responses and develop a preferential T helper type 2 response following immunization with many vaccine antigens. These studies were undertaken to determine whether 1-day-old neonatal mice immunize
- Engineering of noninfectious HIV-1-like particles containing mutant gp41 glycoproteins as vaccine candidates that allow vaccinees to be distinguished from HIV-1 infectees.
- Virology. 1999 May 10;257(2):438-48. Unique Identifier : AIDSLINE MED/99263171
- Rovinski B; Dekaban GA; Cao SX; Yao FL; Persson R; Matthews TJ; Klein MH; Department of Molecular Genetics, Pasteur-Merieux-Connaught; Research Center, North York, Ontario, M2R 3T4, Canada.; brovinski@ca.pmc-vacc.com
- Many AIDS vaccine candidates under development may elicit immune responses similar to those observed in and used to screen human immunodeficiency virus type 1 (HIV-1)-infected individuals. Therefore, it is important to develop vaccine candidates that incorporate antigenic markers and allow vaccinees to be distinguishe
- Functional complementation of the envelope hypervariable V3 loop of human immunodeficiency virus type 1 subtype B by the subtype E V3 loop.
- Virology. 1999 May 10;257(2):491-501. Unique Identifier : AIDSLINE MED/99263176
- Sato H; Kato K; Takebe Y; Laboratory of Molecular Virology and Epidemiology, AIDS Research; Center, National Institute of Infectious Diseases, Toyama 1-23-1,; Shinjuku, Tokyo, 162-8640, Japan. hirosato@nih.go.jp
- The hypervariable V3 loop within gp120 of human immunodeficiency virus type 1 (HIV-1) is the major determinant of cell tropism and the entry coreceptor usage of the virus. However, the information obtained thus far has been from only subtype B from North America and Europe, and little is known about other subtypes who
- Activation of Bcl-2 promoter-directed gene expression by the human immunodeficiency virus type-1 Tat protein.
- Virology. 1999 May 10;257(2):502-10. Unique Identifier : AIDSLINE MED/99263177
- Wang Z; Morris GF; Reed JC; Kelly GD; Morris CB; Department of Pathology and Laboratory Medicine, Tulane Cancer; Center, New Orleans, Louisiana, 70112, USA.
- Human immunodeficiency virus type 1 (HIV-1) Tat transcriptionally activates expression from a number of viral and cellular promoters. Recent studies demonstrate the ability of Tat to differentially modulate cellular responses to apoptotic signaling. The antiapoptotic effects of Tat appear to correlate with increased e
- Antibodies to human T-cell lymphotropic virus type I (HTLV-I) by particle agglutination (PA) test in Korean blood donors.
- Yonsei Med J. 1999 Apr;40(2):173-7. Unique Identifier : AIDSLINE MED/99266264
- Kim JM; Song YG; Oho YC; Park HC; Kwon KH; Kim E; Lee SH; Kim KH; Department of Internal Medicine, Yonsei University College of; Medicine. jmkim@yumc.yonsei.ac.kr
- HTLV-I infection is a recently recognized disease entity that is common in some tropical and subtropical areas, including the southwestern district of Japan . Despite the geographical proximity and frequent cultural exchanges between Korea and Japan, it is understood that Korea is no
- Changing treatment regimens for HIV infection: impact on referral patterns and training needs of family physicians [see comments]
- J Am Board Fam Pract. 1999 Mar-Apr;12(2):115-9. Unique Identifier : AIDSLINE MED/99235639
- Brandon W; Department of Family Practice, Ochsner Clinic and Alton Ochsner; Medical Foundation, New Orleans, LA 70127, USA.
- BACKGROUND: New antiviral medications and laboratory testing have revolutionized the care of patients infected with the human immunodeficiency virus (HIV). The development of complex treatment regimens has intensified debate about whether care should be restricted to experts in HIV care. Few studies detail how these n
- The care of HIV-infected persons: a specialty? [editorial; comment]
- J Am Board Fam Pract. 1999 Mar-Apr;12(2):178-80. Unique Identifier : AIDSLINE MED/99235650
- Carmichael JK
- Angiographic abnormalities in progressive multifocal leukoencephalopathy: an explanation based on neuropathologic findings.
- AJNR Am J Neuroradiol. 1999 Mar;20(3):487-94. Unique Identifier : AIDSLINE MED/99236157
- Nelson PK; Masters LT; Zagzag D; Kelly PJ; Department of Radiology, New York University Medical Center, NY; 10016, USA.
- BACKGROUND AND PURPOSE: Progressive multifocal leukoencephalopathy (PML) is typically occult at angiography and fails to enhance on MR images. After observing angiographic abnormalities characterized by arteriovenous shunting and pathologic parenchymal blush in patients with AIDS-related PML, often in the absence of c
- Testosterone-patch-induced psychotic mania [letter]
- Am J Psychiatry. 1999 Jun;156(6):969. Unique Identifier : AIDSLINE MED/99288417
- Weiss EL; Bowers MB Jr; Mazure CM
- Simultaneous determination of pyrimidine or purine deoxyribonucleoside triphosphates using a polymerase assay.
- Anal Biochem. 1999 May 1;269(2):403-9. Unique Identifier : AIDSLINE MED/99241002
- Roy B; Beuneu C; Roux P; Buc H; Lemaire G; Lepoivre M; Institut de Biochemie Biophysique Cellulaire et Moleculaire; Unite CNRS 571, Universite Paris-Sud, Orsay, France.; beatrice.roy@bbmpc.u-psud.fr
- In this paper, we describe an improved enzymatic assay for the determination of deoxyribonucleoside triphosphates (dNTPs). This is based on the elongation of 32P 5 -end-labeled oligonucleotide primers annealed to complementary oligonucleotide templates. Incorporation within the primer/template (p/t) was catalyzed by t
- Recent advances in varicella-zoster virus infection.
- Ann Intern Med. 1999 Jun 1;130(11):922-32. Unique Identifier : AIDSLINE MED/99296103
- Cohen JI; Brunell PA; Straus SE; Krause PR; Medical Virology Section, Laboratory of Clinical Investigation,; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, MD 20892-1888, USA.
- Varicella-zoster virus has developed a complex strategy that allows it to remain latent in the body and avoid destruction by the immune system. Although varicella and zoster have been recognized since antiquity, several new clinical syndromes--including chronic chickenpox with persistent verrucous lesions and dissemin
- Biochemical and functional interactions between HIV-1 Tat protein and TAR RNA.
- Arch Biochem Biophys. 1999 May 15;365(2):175-85. Unique Identifier : AIDSLINE MED/99262061
- Rana TM; Jeang KT; Department of Pharmacology, Robert Wood Johnson (Rutgers) Medical; School, 675 Hoes Lane, Piscataway, New Jersey, 08854, USA.
- HIV-1 trans-activator of transcription (Tat) is an unusual transcriptional activator in being an RNA-binding protein rather than a DNA-binding protein. Recent findings have greatly advanced our understanding of the transcriptional function(s) of this protein. Here we review how Tat interacts with trans-activation resp
- The ins and outs of HIV Rev.
- Arch Biochem Biophys. 1999 May 15;365(2):186-91. Unique Identifier : AIDSLINE MED/99262062
- Hope TJ; Infectious Disease Laboratory, Salk Institute of Biological; Studies, 10010 North Torrey Pines Road, La Jolla, California,; 92037, USA. hope@salk.edu
- The Rev protein of the human immunodeficiency virus mediates the nuclear export of the intron-containing viral messages. This export is a consequence of the continuous shuttling of HIV Rev between the nucleus and cytoplasm. This shuttling is mediated by a nuclear localization signal and a nuclear export signal contain
- The numerous effector functions of Nef.
- Arch Biochem Biophys. 1999 May 15;365(2):192-8. Unique Identifier : AIDSLINE MED/99262063
- Marsh JW; Laboratory of Molecular Biology, NIMH, Bethesda, Maryland,; 20892-4034, USA. jon@codon.nih.gov
- HIV-1 reverse transcription: a brief overview focused on structure-function relationships among molecules involved in initiation of the reaction.
- Arch Biochem Biophys. 1999 May 15;365(2):199-210. Unique Identifier : AIDSLINE MED/99262064
- Gotte M; Li X; Wainberg MA; McGill AIDS Centre, Lady Davis Institute-Jewish General Hospital,; Montreal, Quebec, H3T 1E2, Canada.
- An early step in the life cycle of the human immunodeficiency virus type 1 (HIV-1) is reverse transcription of viral RNA into proviral DNA, which can then be integrated into the host cell genome. Reverse transcription is a discontinuous process carried out by the viral encoded reverse transcriptase that displays DNA p
- Human acid-labile interferon alpha.
- Arch Immunol Ther Exp (Warsz). 1999;47(2):89-98. Unique Identifier : AIDSLINE MED/99218886
- Piasecki E; Laboratory of Virology, Polish Academy of Sciences, Wroclaw,; Poland.
- In acquired immune deficiency syndrome (AIDS) and autoimmune diseases, like systemic lupus erythematosus (SLE), persisting high levels of interferon (IFN) are detectable in plasma. The IFN has been identified as an unusual human acid-labile IFN-alpha (al-IFN-alpha). Its properties are similar to that of the known alph
- Substance abuse and HIV-gp120: are opiates protective?
- Arch Immunol Ther Exp (Warsz). 1999;47(2):99-106. Unique Identifier : AIDSLINE MED/99218887
- Stefano GB; Neuroscience Research Institute, State University of New York at; Old Westbury 11568, USA.
- There has long been a popular conceptual linkage between human immunodeficiency virus (HIV) acquisition and substance abuse involving needles . Indeed, in vitro studies demonstrate that these substances promote the replication of HIV. Included in these in vitro studies is a linkage or association of tissue damage and
- Pattern of early visual field loss in HIV-infected patients.