1999

[Lymphoid hyperplasia associated with human immunodeficiency virus and Epstein-Barr virus; relationship with lymphomatous pathology]: Ann Pathol. 1998 Oct;18(4):325-30. Unique Identifier : AIDSLINE MED/99044466; Raphael M; Asso-Bonnet M; el Mansouri S; Martin A; Service d'Hematologie Biologique, Hopital Avicenne, Bobigny.
Hepatitis C virus genotypes and the influence of the induction of immunosuppression with anti-thymocyte globulin (ATG) on chronic hepatitis in renal graft recipients.: Unique Identifier : AIDSLINE MED/98329662; Rodrigues A; Pinho L; Lobato L; Queiros A; Castro R; Daniel M; Dias L; Henriques AC; Sarmento A; Guimaraes S; Hepatitis C virus (HCV) exhibits a dramatic genetic variability and several mechanisms of immunological response are unable to control hepatic and extrahepatic replication. Genotype 1 b is associated with more severe clinical manifestations and is less responsive to interferon. In addition, we have reported an increas
CD4+ and CD8+ T cell subset distribution in the blood of small-bowel-grafted rats: modification during graft-versus-host disease.: Transpl Int. 1998;11 Suppl 1:S467-71. Unique Identifier : AIDSLINE MED/98329743; Marni A; Forti D; Fulgenzi A; Corsi M; Cazzulani A; Ferrero ME; Department of Surgery Pizzamiglio II, Ospedale Niguarda, Milan,; Italy.; We studied the modifications of blood T cell distribution following small-bowel allografting in rats under different experimental conditions. Group 1: ACI (RT1a) rats were used as small-bowel donors for ACI x Wistar (RT1y) F1 hybrid rats (WAF1) in which graft-versus-host disease (GVHD) developed. Group 2: WAF1 rats we
Balancing the Th1/Th2 concept in multiple sclerosis.: Immunol Today. 1998 Nov;19(11):489-90. Unique Identifier : AIDSLINE MED/99035945; Laman JD; Thompson EJ; Kappos L; Dept of Immunology, Erasmus University Rotterdam.; Laman@immu.fgg.eur.nl
HIV infection: how effective is drug combination treatment?: Immunol Today. 1998 Nov;19(11):528-32. Unique Identifier : AIDSLINE MED/99035955; Grossman Z; Feinberg M; Kuznetsov V; Dimitrov D; Paul W; NIH Office of AIDS Research, Bethesda, MD 20892, USA.; wepaul@nih.gov; The rate of decline of plasma HIV RNA in patients treated with anti-retroviral drugs has been postulated to reflect the half-lives of previously HIV-infected cells. Here, Zvi Grossman and colleagues argue that the observed decline is explained by the kinetics of ongoing infection cycles. Residual cell-to-cell infectio
Pertussis infection and vaccination induces Th1 cells [letter]: Immunol Today. 1998 Nov;19(11):534. Unique Identifier : AIDSLINE MED/99035957; Brady MT; Mahon BP; Mills KH
Sexual and mother-to-child transmission of the human immunodeficiency virus type 1: a review.: Am J Reprod Immunol. 1998 Sep;40(3):183-6. Unique Identifier : AIDSLINE MED/98436854; Chermann JC; INSERM Unite de Recherche sur les Retrovirus et Maladies,; Technologique de Luminy, Marseille, France.; PROBLEM: Sexual and mother-to-child transmission of the human immunodeficiency virus (HIV) type 1 occurs only with a low percentage of infection. Many instances of sexual intercourse result in no transmission, and only 20% of children are infected from seropositive mothers (3% in mothers treated with azidothymidine).
The radiology of the thoracic manifestations of AIDS.: Crit Rev Diagn Imaging. 1998 Aug;39(4):259-338. Unique Identifier : AIDSLINE MED/98431722; Oldham SA; Barron B; Munden RF; Lamki N; Lamki L; Department of Radiology, University of Texas Houston Health; Science Center 77030, USA.; The thoracic manifestations of AIDS have undergone a gradual metamorphosis, partly due to more awareness about the disease leading to earlier diagnoses and partly due to the fact that research has produced more effective prophylaxis as well as treatment for these patients. Many patients now demonstrate partial or comp
Acute pancreatitis: the role of diagnostic imaging.: Crit Rev Diagn Imaging. 1998 Sep;39(5):339-63. Unique Identifier : AIDSLINE MED/99007960; Dalzell DP; Scharling ES; Ott DJ; Wolfman NT; Department of Radiology, Wake Forest University School of; Medicine, Winston-Salem, N.C 27157-1088, USA.; In the U.S., acute pancreatitis is usually caused by excessive consumption of ethanol or by biliary stone disease. Major pathologic finding and complications include fluid collections within the organ or the adjacent peripancreatic tissues, pseudocysts, pancreatic necrosis, pseudoaneurysm, and abscess formation. Radio
HIV and the family.: J Pierre Fauchard Acad. 1994 Dec;8(4):126. Unique Identifier : AIDSLINE MED/99073063
AIDS cases soar in past year.: J Pierre Fauchard Acad. 1994 Dec;8(4):127-9. Unique Identifier : AIDSLINE MED/99073064; Around 1.5 million people developed AIDS between mid-1993 and mid-1994--three times as many as in the previous 12 months, according to estimates released by GPA on 1 July. About 200,000 of the new cases are thought to be in south and southeast Asia, more than eight times as many as occurred in that region during the p
Ten points for world AIDS day 1994 AIDS and the family.: J Pierre Fauchard Acad. 1994 Dec;8(4):130. Unique Identifier : AIDSLINE MED/99073065
Sexual behaviour research and HIV/AIDS.: J Pierre Fauchard Acad. 1994 Dec;8(4):131-2. Unique Identifier : AIDSLINE MED/99073066; To design effective ways of reducing HIV transmission through sexual intercourse, which accounts for about 90% of all infections among adults and adolescents, we need to know more about how sex occurs and is understood in different cultures. Dr Peter Aggleton, who leaves GPA this summer after two years as head of its
HIV. Genetic effects on immunity immunity to infection. Web alert.: Unique Identifier : AIDSLINE MED/98390150; Greaves DR; Sir William Dunn School of Pathology, Oxford, UK.
Preparing for HIV vaccines that induce cytotoxic T lymphocytes [editorial]: Curr Opin Immunol. 1998 Aug;10(4):379-81. Unique Identifier : AIDSLINE MED/98390151; McMichael A
HIV-2 and T cell recognition.: Curr Opin Immunol. 1998 Aug;10(4):382-7. Unique Identifier : AIDSLINE MED/98390152; Whittle HC; Ariyoshi K; Rowland-Jones S; MRC Laboratories, The Gambia, West Africa. whittle@commit.gm; HIV-2 is less pathogenic and less transmissible than HIV-1. Recent research in relation to deletions in the HIV nef gene and to immune cross-reactions between infections by HIV-2, HIV-1 and simian immunodeficiency virus suggests that T cell recognition and the control of viral replication may be more efficient in HIV-
Cross-clade T cell recognition of HIV.1.: Curr Opin Immunol. 1998 Aug;10(4):388-92. Unique Identifier : AIDSLINE MED/98390153; Gotch F; Department of Immunology, Chelsea and Westminster Hospital,; London, UK.; Despite considerable advances in antiviral therapy for HIV infection, successful global intervention will require an effective vaccine. Current evidence suggests that cytotoxic T lymphocyte responses will be an important component of such vaccination. Recent evidence suggests that cytotoxic T lymphocytes raised agains
Protective immunity induced by live attenuated simian immunodeficiency virus.: Curr Opin Immunol. 1998 Aug;10(4):436-43. Unique Identifier : AIDSLINE MED/98390160; Johnson RP; Desrosiers RC; Division of Immunology, New England Regional Primate Research; Center, Harvard Medical School, Southborough, MA 01772, USA.; pjohnson@warren.med.harvard.edu; Lack of information on the mechanisms of protective immunity to AIDS virus infection represents a major obstacle to the development of a rational strategy for an effective HIV vaccine. In macaques, immunization with live attenuated simian immunodeficiency viruses has induced the most potent protective immunity and con
Therapeutic vaccination against chronic viral infection: the importance of cooperation between CD4+ and CD8+ T cells.: Curr Opin Immunol. 1998 Aug;10(4):444-9. Unique Identifier : AIDSLINE MED/98390161; Zajac AJ; Murali-Krishna K; Blattman JN; Ahmed R; Emory Vaccine Center, Emory University School of Medicine,; Atlanta, GA 30322, USA.; The goal of therapeutic vaccination is to elicit an antiviral immune response within persistently infected individuals and consequently eradicate the infection. CD8+ T cells are potent mediators of viral clearance; however, during chronic infections CD4+ T cell help is required to sustain antiviral CD8+ T cell activit
Cytotoxic T cell responses to intracellular pathogens.: Curr Opin Immunol. 1998 Aug;10(4):471-7. Unique Identifier : AIDSLINE MED/98390165; Stenger S; Modlin RL; Institut fur Klinische Mikrobiologie, Immunologie und Hygiene,; Universitat Erlangen, Germany.; Host defense against intracellular pathogens is thought to require cytotoxic T cells. Recent studies have investigated the impact of host cell lysis and cytokine production by cytotoxic T lymphocytes on the fate of intracellular pathogens. The identification of two mechanisms of lysis induced by cytotoxic T lymphocyte
Adaptation to promiscuous usage of CC and CXC-chemokine coreceptors in vivo correlates with HIV-1 disease progression.: AIDS. 1998 Sep 10;12(13):F137-43. Unique Identifier : AIDSLINE MED/98435802; Xiao L; Rudolph DL; Owen SM; Spira TJ; Lal RB; HIV/Retrovirus Diseases Branch, Division of AIDS, STD, and TB; Laboratory Research, National Center for Infectious Diseases,; Centers for Disease Control and Prevention, Public Health; Services, US Department of Health and Human Serv.; OBJECTIVE: To study coreceptor usage of sequential primary HIV-1 isolates in a longitudinal follow-up cohort of HIV-1-infected men to understand its contribution to pathogenesis of HIV disease. DESIGN: Viral coreceptor usage of sequential primary isolates from HIV-1-infected individuals was examined at various timepoi
Target cell availability and the successful suppression of HIV by hydroxyurea and didanosine [editorial]: AIDS. 1998 Sep 10;12(13):1567-70. Unique Identifier : AIDSLINE MED/98435803; De Boer RJ; Boucher CA; Perelson AS
Cost-effectiveness and cost-benefit in the prevention of mother-to-child transmission of HIV in developing countries. Ghent International Working Group on Mother-to-Child Transmission of HIV [editorial; comment]: AIDS. 1998 Sep 10;12(13):1571-80. Unique Identifier : AIDSLINE MED/98435804; Newell ML; Dabis F; Tolley K; Whynes D
Prognostic significance of plasma markers of immune activation, HIV viral load and CD4 T-cell measurements.: AIDS. 1998 Sep 10;12(13):1581-90. Unique Identifier : AIDSLINE MED/98435805; Fahey JL; Taylor JM; Manna B; Nishanian P; Aziz N; Giorgi JV; Detels R; Department of Microbiology and Immunology, Center for; Interdisciplinary Research in Immunology and Disease, UCLA School; of Medicine, Los Angeles, California 90095-1747, USA.; OBJECTIVE: To evaluate the prognostic significance for AIDS occurrence of plasma levels of immune activation markers in comparison with and in conjunction with HIV viral load and CD4 T-cell measurements. DESIGN: A retrospective analysis was conducted of three plasma activation markers, the soluble tumor necrosis facto
Neutralizing antibodies are positively associated with CD4+ T-cell counts and T-cell function in long-term AIDS-free infection.: AIDS. 1998 Sep 10;12(13):1591-600. Unique Identifier : AIDSLINE MED/98435806; Carotenuto P; Looij D; Keldermans L; de Wolf F; Goudsmit J; Department of Human Retrovirology, Academic Medical Centre,; University of Amsterdam, The Netherlands.; OBJECTIVES: To assess the dynamics of neutralizing antibodies (NAb) in long-term AIDS-free HIV-1-infected subjects and establish correlations with known markers of disease progression. DESIGN: Cross-sectional study using sera collected from long-term non-progressors (LTNP) 8 years after seroconversion or study entry.
Change in fluconazole susceptibility patterns and genetic relationship among oral Candida albicans isolates.: AIDS. 1998 Sep 10;12(13):1601-10. Unique Identifier : AIDSLINE MED/98435807; Diaz-Guerra TM; Martinez-Suarez JV; Laguna F; Valencia E; Rodriguez-Tudela JL; Unidad de Micologia, Centro Nacional de Microbiologia,; Majadahonda, Instituto de Salud Carlos III, Madrid, Spain.; OBJECTIVE: To assess the genetic homogeneity or heterogeneity within each set of Candida albicans isolates colonizing/infecting the oral cavities of HIV-infected patients undergoing azole therapy when changes in susceptibility to fluconazole were detected. DESIGN: Fourteen HIV-positive patients suffering recurrent epi
HIV protease genotype and viral sensitivity to HIV protease inhibitors following saquinavir therapy.: AIDS. 1998 Sep 10;12(13):1611-8. Unique Identifier : AIDSLINE MED/98435808; Craig C; Race E; Sheldon J; Whittaker L; Gilbert S; Moffatt A; Rose J; Dissanayeke S; Chirn GW; Duncan IB; Cammack N; Roche Discovery Welwyn, Welwyn Garden City, Herts, UK.; OBJECTIVE: To examine the relationship between HIV protease genotype and altered protease inhibitor sensitivity of isolates from patients after therapy with saquinavir (SQV) in its hard gelatin formulation. DESIGN: Forty-one post-therapy isolates and corresponding baseline samples were obtained from 37 patients in fou
Suppression of plasma viral load below 20 copies/ml is required to achieve a long-term response to therapy.: AIDS. 1998 Sep 10;12(13):1619-24. Unique Identifier : AIDSLINE MED/98435809; Raboud JM; Montaner JS; Conway B; Rae S; Reiss P; Vella S; Cooper D; Lange J; Harris M; Wainberg MA; Robinson P; Myers M; Hall D; Canadian HIV Trials Network and Centre for Excellence in; HIV/AIDS, St Paul's Hospital/University of British Columbia,; Vancouver.; BACKGROUND: Current guidelines state that the goal of antiretroviral therapy for HIV-infected individuals is to suppress plasma viral load (pVL) to below 400 copies/ml. METHODS: Predictors of achieving and maintaining pVL suppression were examined in a randomized trial of combinations of zidovudine,
Treatment response and durability of a double protease inhibitor therapy with saquinavir and ritonavir in an observational cohort of HIV-1-infected individuals.: AIDS. 1998 Sep 10;12(13):1625-30. Unique Identifier : AIDSLINE MED/98435810; Kaufmann GR; Duncombe C; Cunningham P; Beveridge A; Carr A; Sayer D; French M; Cooper DA; Centre for Immunology, St Vincent's Hospital, Sydney, NSW,; Australia.; OBJECTIVE: To evaluate treatment response, durability and tolerance of a four-drug regimen including saquinavir and ritonavir in combination with either zidovudine/lamivudine or stavudine
Clinical outcome and predictive factors of failure of highly active antiretroviral therapy in antiretroviral-experienced patients in advanced stages of HIV-1 infection.: AIDS. 1998 Sep 10;12(13):1631-7. Unique Identifier : AIDSLINE MED/98435811; d'Arminio Monforte A; Testa L; Adorni F; Chiesa E; Bini T; Moscatelli GC; Abeli C; Rusconi S; Sollima S; Balotta C; Musicco M; Galli M; Moroni M; Institute of Infectious and Tropical Diseases, University of; Milan, Italy.; OBJECTIVE: To verify the effectiveness of highly active antiretroviral therapy (HAART) and to identify any factors predictive of clinical outcome in a clinical setting. DESIGN: Observational study. METHODS: Treatment failure (i.e., the occurrence of new or recurrent AIDS-defining events, death or any definitive discon
The relative prognostic value of plasma HIV RNA levels and CD4 lymphocyte counts in advanced HIV infection.: AIDS. 1998 Sep 10;12(13):1639-43. Unique Identifier : AIDSLINE MED/98435812; Cozzi Lepri A; Katzenstein TL; Ullum H; Phillips AN; Skinhoj P; Gerstoft J; Pedersen BK; Royal Free Centre for HIV Medicine & Department of Primary Care; and Population Sciences, Royal Free and University College; Medical School, University College London, UK.; OBJECTIVE: It has been suggested that the plasma HIV RNA level is a better predictor of AIDS and death than the CD4 lymphocyte count. We assessed whether the prognostic value of plasma virus levels was different according to the CD4 count. DESIGN: Prospective cohort study of HIV-infected patients followed for a median
The effect of protease inhibitors on weight and body composition in HIV-infected patients.: AIDS. 1998 Sep 10;12(13):1645-51. Unique Identifier : AIDSLINE MED/98435813; Silva M; Skolnik PR; Gorbach SL; Spiegelman D; Wilson IB; Fernandez-DiFranco MG; Knox TA; Department of Community Health, Tufts University School of; Medicine, and the New England Medical Center Hospitals, Boston,; Massachusetts 02111, USA.; OBJECTIVES: To determine the nutritional changes that occur in HIV-infected patients receiving protease inhibitor (PI) therapy and to determine the effects of PI treatment on physical functioning and health perceptions in patients with HIV infection. DESIGN: Longitudinal data analysis of 38 patients from a large Nutri
Effects of vitamin E and C supplementation on oxidative stress and viral load in HIV-infected subjects.: AIDS. 1998 Sep 10;12(13):1653-9. Unique Identifier : AIDSLINE MED/98435814; Allard JP; Aghdassi E; Chau J; Tam C; Kovacs CM; Salit IE; Walmsley SL; Department of Medicine, University of Toronto, Ontario, Canada.; OBJECTIVES: The HIV-infected population is known to be oxidatively stressed and deficient in antioxidant micronutrients. Since in vitro replication of HIV is increased with oxidative stress, this study assessed the effect of antioxidant vitamin supplementation on lipid peroxidation, a measure of oxidative stress, and
Mycobacterium xenopi in HIV-infected patients: an emerging pathogen.: AIDS. 1998 Sep 10;12(13):1661-6. Unique Identifier : AIDSLINE MED/98435815; Juffermans NP; Verbon A; Danner SA; Kuijper EJ; Speelman P; Department of Internal Medicine, University of Amsterdam, The; Netherlands.; BACKGROUND: Mycobacterium xenopi is associated with pulmonary disease in patients with loss of local or general host defence. OBJECTIVES: To determine the occurrence of M. xenopi in our hospital during 1987-1992 and 1993-1996, as well as the association of M. xenopi with HIV infection in 1993-1996; to evaluate the cli
Taste and smell complaints in HIV-infected patients.: AIDS. 1998 Sep 10;12(13):1667-74. Unique Identifier : AIDSLINE MED/98435816; Heald AE; Pieper CF; Schiffman SS; Department of Medicine, Duke University Medical Center, Durham,; North Carolina 27710, USA.; OBJECTIVES: To define the scope of taste and smell (chemosensory) complaints amongst HIV-infected persons in the study population; to evaluate the clinical factors associated with chemosensory complaints; and to determine the impact of chemosensory complaints on quality of life. DESIGN: Cross-sectional survey. SETTING
Antiretroviral drugs as a public health intervention for pregnant HIV-infected women in rural South Africa: an issue of cost-effectiveness and capacity [see comments]: AIDS. 1998 Sep 10;12(13):1675-82. Unique Identifier : AIDSLINE MED/98435817; Wilkinson D; Floyd K; Gilks CF; Centre for Epidemiological Research in Southern Africa, Medical; Research Council, Mtubatuba.; OBJECTIVE: To estimate cost-effectiveness and capacity requirements for providing antiretroviral drugs to pregnant HIV-infected women in rural South Africa . SETTING: Hlabisa health district, where HIV prevalence among pregnant women was 26.0% in 1997. METHODS: Calculation of the n
Pneumococcal vaccination in HIV-1-infected adults in Uganda: humoral response and two vaccine failures.: AIDS. 1998 Sep 10;12(13):1683-9. Unique Identifier : AIDSLINE MED/98435818; French N; Gilks CF; Mujugira A; Fasching C; O'Brien J; Janoff EN; Medical Research Council Programme on AIDS in Uganda, Uganda; Virus Research Institute, Entebbe.; OBJECTIVES: To assess the feasibility of establishing a pneumococcal vaccine trial among HIV-1-infected adults in Uganda and to characterize their responses to 23-valent pneumococcal polysaccharide vaccine. DESIGN: An open-label pilot trial to assess recruitment and compliance of H
Effects of age at seroconversion and baseline HIV RNA level on the loss of CD4+ cells among persons with hemophilia. Multicenter Hemophilia Cohort Study.: AIDS. 1998 Sep 10;12(13):1691-7. Unique Identifier : AIDSLINE MED/98435819; Touloumi G; Hatzakis A; Rosenberg PS; O'Brien TR; Goedert JJ; Department of Hygiene and Epidemiology, Athens University Medical; School, Greece.; OBJECTIVE: To assess the impact of age at seroconversion and HIV RNA level in serum during early chronic infection on the initial values and subsequent trends (slopes) of CD4+ lymphocyte counts. DESIGN AND METHODS: In a cohort of 137 HIV-1-positive hemophiliacs with well-estimated dates of seroconversion, baseline HIV
Bacterial vaginosis and disturbances of vaginal flora: association with increased acquisition of HIV.: Unique Identifier : AIDSLINE MED/98435820; Taha TE; Hoover DR; Dallabetta GA; Kumwenda NI; Mtimavalye LA; Yang LP; Liomba GN; Broadhead RL; Chiphangwi JD; Miotti PG
Declining HIV-2 prevalence and incidence among men in a community study from Guinea-Bissau.: Unique Identifier : AIDSLINE MED/98435821; Larsen O; da Silva Z; Sandstrom A; Andersen PK; Andersson S; Poulsen AG; Melbye M; Dias F; Naucler A; Aaby P; Projecto de Saude de Bandim, Bissau, Guinea-Bissau.; OBJECTIVE: To assess the present level of HIV-2 infection in an adult population in Bissau and to evaluate sex and age-specific changes in HIV-2 prevalence and incidence between 1987 and 1996. DESIGN AND METHODS: Sex and age-specific changes in HIV-2 prevalence were evaluated comparing a survey from 1987 in a sample o
Highly active antiretroviral therapy leads to a significant but delayed increase of CD45RA+ T-helper cells [letter]: AIDS. 1998 Sep 10;12(13):1715-6. Unique Identifier : AIDSLINE MED/98435822; Degen O; Stellbrink HJ; Lauer J; van Lunzen J
Complete regression of AIDS-related Kaposi's sarcoma-associated human herpesvirus-8 during therapy with indinavir [letter]: AIDS. 1998 Sep 10;12(13):1717-9. Unique Identifier : AIDSLINE MED/98435823; Martinelli C; Zazzi M; Ambu S; Bartolozzi D; Corsi P; Leoncini F
Herpes zoster infection in HIV-seropositive patients associated with highly active antiretroviral therapy [letter]: AIDS. 1998 Sep 10;12(13):1719-20. Unique Identifier : AIDSLINE MED/98435824; Aldeen T; Hay P; Davidson F; Lau R
Progressive multifocal leukoencephalopathy following initiation of highly active antiretroviral therapy [letter]: AIDS. 1998 Sep 10;12(13):1720-2. Unique Identifier : AIDSLINE MED/98435825; Mayo J; Collazos J; Martinez E
Acute hepatitis in HIV-infected patients during ritonavir treatment [letter]: AIDS. 1998 Sep 10;12(13):1722-4. Unique Identifier : AIDSLINE MED/98435826; Arribas JR; Ibanez C; Ruiz-Antoran B; Pena JM; Esteban-Calvo C; Frias J; Vazquez JJ; Gonzalez-Garcia JJ
Bacterial lipopolysaccharide is a potent inhibitor of HIV-1 replication in T lymphocytes and macrophages [letter]: AIDS. 1998 Sep 10;12(13):1724-6. Unique Identifier : AIDSLINE MED/98435827; Alfano M; Schmidtmayerova H; Bukrinsky M
Use of highly sensitive assays for the evaluation of post-exposure HIV prophylaxis [letter]: AIDS. 1998 Sep 10;12(13):1726-7. Unique Identifier : AIDSLINE MED/98435828; Schockmel GA; Balavoine JF; Yerly S; Perrin L
Performance of an ultrasensitive assay to test undetectable viral load specimens using the branched DNA assay [letter]: AIDS. 1998 Sep 10;12(13):1727-9. Unique Identifier : AIDSLINE MED/98435829; de Mendoza C; Holguin A; Soriano V
Comparison of zidovudine phosphorylation in lymph nodes and peripheral blood mononuclear cells in HIV-infected patients. DATRI 012 Study Group [letter]: AIDS. 1998 Sep 10;12(13):1729-31. Unique Identifier : AIDSLINE MED/98435830; Peter K; Lalezari JP; Pearl JM; Thevanayagam L; Gambertoglio JG
Increased susceptibility to HIV-1 infection of peripheral blood mononuclear cells from chronically immune-activated individuals [letter]: AIDS. 1998 Sep 10;12(13):1731-3. Unique Identifier : AIDSLINE MED/98435831; Shapira-Nahor O; Kalinkovich A; Weisman Z; Greenberg Z; Nahmias J; Shapiro M; Panet A; Bentwich Z
Social marketing sexually transmitted disease and HIV prevention: a consumer-centered approach to achieving behaviour change.: AIDS. 1998;12 Suppl 2:S1-9. Unique Identifier : AIDSLINE MED/99006842; Lamptey PR; Price JE; Family Health International, Arlington, Virginia, USA.; This paper proposes that international sexually transmitted disease (STD)/HIV prevention efforts might be enhanced by the application of social marketing principles. It first outlines the conceptual basis of social marketing approaches to health behaviour change generally and then explores key issues and opportunities
Field experiences: measuring capacity building efforts in HIV/AIDS prevention programmes.: AIDS. 1998;12 Suppl 2:S109-17. Unique Identifier : AIDSLINE MED/99006854; Kotellos KA; Amon JJ; Benazerga WM; Division of HIV/AIDS, Family Health International, Arlington,; Virginia, USA.; OBJECTIVE: To present a theoretical and practical means for the evaluation of organizational and institutional development (capacity building) in HIV/AIDS prevention programmes in developing countries. METHODS: Multiple frameworks, methodologies and paradigms for the evaluation of organizational and institutional deve
The affordability of antiretroviral therapy in developing countries: what policymakers need to know.: AIDS. 1998;12 Suppl 2:S11-8. Unique Identifier : AIDSLINE MED/99006843; Forsythe SS; AIDSCAP/Family Health International.; OBJECTIVE: The objective of this paper is to assist policymakers in developing countries and international donors by providing an outline of economic information needed to make a decision regarding the purchase of drugs to provide highly active antiretroviral therapy (HAART). DESIGN: The following paper: (i) reviews e
Targeted intervention research studies on sexually transmitted diseases (STD): methodology, selected findings and implications for STD service delivery and communications.: AIDS. 1998;12 Suppl 2:S119-26. Unique Identifier : AIDSLINE MED/99006855; Field ML; Price J; Niang C; N'tcha J; Zwane IT; Lurie M; Nxumalo M; Dialmy A; Manhart L; Gebre A; Saidel T; Dallabetta G; Family Health International, Arlington, Virginia, USA.; OBJECTIVE: To report the findings of qualitative studies designed for use in improving sexually transmitted disease (STD) programs. The studies explore illness conceptions and treatment behaviors for STD in five African countries. These targeted intervention research (TIR) studies were performed on clinic-based and co
Beyond the dichotomy: linking HIV prevention with care.: AIDS. 1998;12 Suppl 2:S19-26. Unique Identifier : AIDSLINE MED/99006844; MacNeil JM; Anderson S; AIDSCAP Project of Family Health International, Arlington, VA; 22201, USA.; In the past decade, the global strategy against AIDS has focused primarily upon prevention. Regardless of the effectiveness of prevention efforts being made today and advances in treatments, the numbers of persons infected globally continues to grow at an alarming rate, especially in developing countries. With numbers
AVERT: a user-friendly model to estimate the impact of HIV/sexually transmitted disease prevention interventions on HIV transmission.: AIDS. 1998;12 Suppl 2:S27-35. Unique Identifier : AIDSLINE MED/99006845; Rehle TM; Saidel TJ; Hassig SE; Bouey PD; Gaillard EM; Sokal DC; AIDS Control and Prevention Project, Family Health International,; Arlington, Virginia, USA.; OBJECTIVE: To introduce the newly developed AVERT model by describing the purpose, logic, advantages and limitations of the model, to validate the model s estimates against seroconversion data from a large randomized controlled trial, and to provide practical examples of its applications. DESIGN: Static, deterministic
HIV risk behavioral surveillance: a methodology for monitoring behavioral trends.: AIDS. 1998;12 Suppl 2:S37-46. Unique Identifier : AIDSLINE MED/99006846; Mills S; Saidel T; Bennett A; Rehle T; Hogle J; Brown T; Magnani R; AIDS Control and Prevention Project, Family Health International,; Bangkok, Thailand. smills@fhibkk.org; OBJECTIVE: This article summarizes issues and recommendations for conducting HIV risk behavioral surveillance surveys (BSS) based on experiences from ten BSS projects in eight countries in Asia and Africa. BACKGROUND: BSS consists of systematic and repeated cross-sectional surveys of HIV and sexually transmitted disea
Evolution of socioeconomic impact assessments of HIV/AIDS.: AIDS. 1998;12 Suppl 2:S47-55. Unique Identifier : AIDSLINE MED/99006847; Forsythe S; Rau B; Policy Unit of AIDSCAP/Family Health International.; OBJECTIVE: The objective of this paper is to describe how and why socioeconomic impact assessments, as applied to HIV/AIDS in developing countries, have evolved over time and to discuss the direction that this field should be taking in the future. DESIGN: This paper involves a review of existing literature and incorpo
Indicators and the measurement of STD case management in developing countries. STD PI6&7 Working Group.: Unique Identifier : AIDSLINE MED/99006848
Improving sexually transmitted disease management in the private sector: the Jamaica experience.: Unique Identifier : AIDSLINE MED/99006849; Green M
Cost of providing sexually transmitted disease services in Bangkok.: AIDS. 1998;12 Suppl 2:S73-80. Unique Identifier : AIDSLINE MED/99006850; Forsythe S; Mangkalopakorn C; Chitwarakorn A; Masvichian N; HIV/AIDS Work Programme, Liverpool School of Tropical Medicine,; UK.; OBJECTIVE: The main purpose of this study was to assess the economic costs of sexually transmitted disease (STD) treatment and to identify opportunities for sustaining Bangkok s STD clinics. DESIGN: A cost analysis was used to assess the resources required to provide (i) STD services, (ii) additional services at STD c
The role of pharmacists in HIV/STD prevention: evaluation of an STD syndromic management intervention in Nepal.: AIDS. 1998;12 Suppl 2:S81-7. Unique Identifier : AIDSLINE MED/99006851; Tuladhar SM; Mills S; Acharya S; Pradhan M; Pollock J; Dallabetta G; New ERA, Kathmandu, Nepal.; OBJECTIVE: To evaluate the effects of a pilot sexually transmitted disease (STD) syndromic case management training for pharmacists in Nepal on STD drug dispensing behavior, HIV/STD prevention communication, and condom promotion and
Is HIV/STD control in Jamaica making a difference?: AIDS. 1998;12 Suppl 2:S89-98. Unique Identifier : AIDSLINE MED/99006852; Figueroa JP; Brathwaite AR; Wedderburn M; Ward E; Lweis-Bell K; Amon JJ; Williams Y; Williams E; Ministry of Health, Kingston, Jamaica.; OBJECTIVE: To assess the impact of the comprehensive HIV/STD Control Program established in Jamaica since the late 1980s on the HIV/AIDS epidemic. METHODS: AIDS case reports, HIV testing of blood donors, antenatal clinic attenders (ANC), food service workers, sexually transmitted
Applying social, behavioral and evaluation research to developing country HIV prevention programs.: AIDS. 1998;12 Suppl 2:S99-108. Unique Identifier : AIDSLINE MED/99006853; MacNeil JM; Hogle J; Family Health International's AIDSCAP Project, Arlington,; Virginia, USA.; OBJECTIVE: To examine the role that social, behavioral and evaluation research played in a 6-year global HIV prevention program working in 45 developing countries. METHODS: Computerized review of project database inventories: 320 research abstracts, 591 subproject abstracts, on-line literature search of project peer-r
Synthesis and in vitro antimicrobial and antitumoral screening of novel lipophilic isoniazid analogues. VI.: Boll Chim Farm. 1998 Jul-Aug;137(7):267-76. Unique Identifier : AIDSLINE MED/99011574; Vigorita MG; Ottana R; Maccari R; Monforte F; Bisignano G; Pizzimenti FC; Dipartimento Farmaco-chimico, Universita di Messina, Italy.; Various kinds of lipophilic analogues of isonicotinic acid hydrazide (Isoniazid) were synthesized and in vitro explored in a search for antimycobacterial agents with extended activity spectrum against pathogens responsible for the AIDS-associated diseases. The primary in vitro screening showed that a) isonicotinoylhyd
AIDS-related malignancies.: Ann Med. 1998 Aug;30(4):323-44. Unique Identifier : AIDSLINE MED/98455152; Smith C; Lilly S; Mann KP; Livingston E; Myers S; Lyerly HK; Miralles GD; Department of Medicine, Duke University Medical Center, Durham,; NC 27710, USA.; In the US over one million persons are currently infected with the HIV, over half a million have had AIDS, and over 300,000 have died from AIDS. Worldwide, it is estimated that more than 17 million people are currently infected with HIV, and over 1,200,000 cases of AIDS have been reported to the
PCR for HBV, HCV and HIV-1 experiences and first results from a routine screening programme in a large blood transfusion service.: Biologicals. 1998 Jun;26(2):101-4. Unique Identifier : AIDSLINE MED/99030780; Schottstedt V; Tuma W; Bunger G; Lefevre H; Red Cross Blood Transfusion Service North-Rhine Westfalia,; Germany.; We adapted the PCR method to screen up to 3000 blood donations per day for hepatitis B, hepatitis C and HIV-1 virus contamination. Up to 600 aliquots (average 418 donations) are pooled by using an automatic sample processor with disposable tips (validated to avoid contamination) taken from blood donations which are se
Inactivation of viruses by beta-propiolactone in human cryo poor plasma and IgG concentrates.: Unique Identifier : AIDSLINE MED/99030788; Scheidler A; Rokos K; Reuter T; Ebermann R; Pauli G; Virus inactivation by cold treatment with beta-propiolactone
Emergence of new viral infections: implications for the blood supply.: Biologicals. 1998 Jun;26(2):77-84. Unique Identifier : AIDSLINE MED/99030776; Nathanson N; Department of Microbiology, University of Pennsylvania Medical; Center, 263 Clinical Research Building, Philadelphia, PA; 19104-6146, USA.; New viral infections of humans appear to be emerging at an increasing tempo, probably due to technological developments and societal changes that have enhanced the ability of viruses to invade and spread within the human population. Emergence can be due to several discrete phenomena. Existing viruses of humans continu
Surveillance for transfusion-transmitted viral infections in the United States.: Biologicals. 1998 Jun;26(2):85-8. Unique Identifier : AIDSLINE MED/99030777; Chamberland ME; Centers for Disease and Prevention, Division of Viral and; Rickettsial Diseases, Atlanta, GA 30333, USA.; Surveillance is part of a multi-faceted programme to monitor the safety of the U. S. blood supply. The Centers for Disease Control and Prevention administers several national surveillance programmes, including pathogen- and disease-specific systems (e.g. human immunodeficiency virus, hepatitis) and programmes that foc
[Mental and physical impairment, socio-economic resources and care strategies in people with HIV infection]: Ann Ig. 1998 May-Jun;10(3):189-99. Unique Identifier : AIDSLINE MED/99050538; Mancinelli S; Palombi L; Liotta G; Doro Altan A; Riccardi F; Narciso P; Marazzi MC; Catt. di Igiene, Universita di Tor Vergata, Roma.
NMR study and comparison of the antigenic properties of a peptide recognized by two HIV-1 neutralizing antibodies.: J Mol Recognit. 1997 Nov-Dec;10(6):256-61. Unique Identifier : AIDSLINE MED/98443588; Tsang P; Mu X; Wu G; Durda PJ; Department of Chemistry, University of Cincinnati, OH 45221-0172,; USA.; Fab-peptide complexes formed between a 15 residue peptide derived from the HIV-1 gp120 V3 loop and two of its cognate monoclonal antibodies, 5023A and 5025A, were studied using isotope-edited solution nuclear magnetic resonance (NMR) techniques. Since these antibodies neutralize HIV-1 virus with different strain speci
The role of dendritic cells in the infection of CD4+ T cells with the human immunodeficiency virus: use of dendritic cells from individuals homozygous for the delta32CCR5 allele as a model.: AIDS Res Hum Retroviruses. 1998 Sep 1;14(13):1109-13. Unique Identifier : AIDSLINE MED/98407600; Dybul M; Weissman D; Rubbert A; Machado E; Cohn M; Ehler L; O'Callahan M; Mizell S; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892, USA.; Despite exposure to multiple strains of both macrophage (M)-tropic and T cell (T)-tropic HIV, primary infection is largely restricted to relatively homogeneous M-tropic virus. Since dendritic cells (DCs) play a pivotal role in the early events of HIV infection, several studies have focused on the role of DCs in this r
Molecular characterization of five neutralizing anti-HIV type 1 antibodies: identification of nonconventional D segments in the human monoclonal antibodies 2G12 and 2F5.: AIDS Res Hum Retroviruses. 1998 Sep 1;14(13):1115-28. Unique Identifier : AIDSLINE MED/98407601; Kunert R; Ruker F; Katinger H; Institute of Applied Microbiology, University of Agricultural; Sciences, Vienna, Austria.; We have stabilized a panel of 33 hybridomas producing human monoclonal antibodies (MAbs) against HIV-1 gp160 and p24. Five of these antibodies were able to neutralize different HIV-1 isolates, and two of them (2F5 and 2G12) revealed remarkable potential to neutralize primary virus isolates of different clades in sever
Effect of major deletions in the V1 and V2 loops of a macrophage-tropic HIV type 1 isolate on viral envelope structure, cell entry, and replication.: AIDS Res Hum Retroviruses. 1998 Sep 1;14(13):1129-39. Unique Identifier : AIDSLINE MED/98407602; Stamatatos L; Wiskerchen M; Cheng-Mayer C; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, New York 10021, USA.; Two HIV-1 envelope mutant proteins were generated by introducing deletions in the first and second hypervariable gp120 regions (V1 and V2 loops, respectively) of a macrophage-tropic primary HIV-1 isolate, SF162, to study the effect of the deleted sequences on envelope structure, viral entry, and replication potentials
Cell-associated viral RNA expression during acute infection with HIV type 1.: AIDS Res Hum Retroviruses. 1998 Sep 1;14(13):1141-9. Unique Identifier : AIDSLINE MED/98407603; Riggs NL; Little SJ; Richman DD; Guatelli JC; Department of Medicine, University of California San Diego, La; Jolla 92093, USA.; The mechanism of decline in viremia following acute infection with HIV is unknown. To characterize this process virologically, the expression of viral RNAs was analyzed in samples of peripheral blood mononuclear cells (PBMCs) from a patient who experienced a 100-fold decline in plasma viremia over a 13-day period prio
Optimization of polymerase chain reaction for detection of HIV type 2 DNA.: AIDS Res Hum Retroviruses. 1998 Sep 1;14(13):1151-6. Unique Identifier : AIDSLINE MED/98407604; Walther L; Grankvist O; Mirzai B; da Silva Z; Fredlund H; Biberfeld G; Thorstensson R; Swedish Institute for Infectious Disease Control and Microbiology; and Tumor Biology Center, Karolinska Institute, Stockholm.; The aim of this study was to increase the sensitivity of an earlier version of an HIV-2 nested PCR assay based on primers in the gag, pol, LTR, and env regions. The assay was first optimized with regard to concentrations of dNTP, MgCl2, and primers, using a method that allowed optimization of all three parameters in o
Antibodies to the HIV type 2 core protein p26 and Vpx: association with disease progression.: AIDS Res Hum Retroviruses. 1998 Sep 1;14(13):1157-62. Unique Identifier : AIDSLINE MED/98407605; Popper SJ; Sankale JL; Thior I; Siby T; Marlink RG; Mboup S; Essex M; Kanki PJ; Harvard AIDS Institute, Harvard School of Public Health, Boston,; Massachusetts 02115, USA.; A longitudinal cohort study was conducted to define the prevalence and temporal pattern of antibody response to the HIV-2 virion-associated proteins p26gag and Vpx. One hundred and forty-one asymptomatic HIV-2-infected women were enrolled, and followed for up to 11 years. Eighty-one percent of the subjects had antibod
SIV-associated nephropathy in rhesus macaques infected with lymphocyte-tropic SIVmac239.: AIDS Res Hum Retroviruses. 1998 Sep 1;14(13):1163-80. Unique Identifier : AIDSLINE MED/98407606; Gattone VH 2nd; Tian C; Zhuge W; Sahni M; Narayan O; Stephens EB; Department of Anatomy and Cell Biology, University of Kansas; Medical Center, Kansas City 66160, USA.; We examined the renal pathology and viral genetic changes following inoculation of six rhesus macaques with lymphocyte-tropic SIVmac239. Portions of the renal cortex were sieved into glomerular and tubulointerstitial (TI) fractions and examined for SIVmac sequences by PCR and for p27 core antigen. SIVmac sequences wer
Phenotypic changes in peripheral blood monocytes of cynomolgus monkeys acutely infected with simian immunodeficiency virus.: Unique Identifier : AIDSLINE MED/98407607; Otani I; Akari H; Nam KH; Mori K; Suzuki E; Shibata H; Doi K; Terao K; Yosikawa Y; Tsukuba Primate Center, National Institute of Infectious; Diseases, Ibaraki, Japan.; The quantitative and phenotypic changes of peripheral blood monocytes during the acute stage of simian immunodeficiency virus infection were investigated. We inoculated intravenously three cynomolgus monkeys (Macaca fascicularis) with 100 TCID50 of SIVmac239 and collected whole blood twice a week until 35 days postino
Mechanisms of protection induced by attenuated simian immunodeficiency virus. II. Lymphocyte depletion does not abrogate protection.: AIDS Res Hum Retroviruses. 1998 Sep 1;14(13):1187-98. Unique Identifier : AIDSLINE MED/98407608; Stebbings R; Stott J; Almond N; Hull R; Lines J; Silvera P; Sangster R; Corcoran T; Rose J; Cobbold S; Gotch F; McMichael A; Walker B; Division of Immunobiology, National Institute for Biological; Standards and Control, South Mimms, Potters Bar, Herts, UK.; To determine the role that cellular immune responses play in the protection conferred by vaccination with attenuated SIVmac32H (pC8), we have attempted to deplete macaques of their CD8+ cells prior to challenge with wild-type SIVmac32H (pJ5). In two of four pC8-infected macaques, N109 and N112, a transient partial dep
Sequence analysis of the first HTLV-I infection in Germany without relations to endemic areas.: AIDS Res Hum Retroviruses. 1998 Sep 1;14(13):1199-203. Unique Identifier : AIDSLINE MED/98407609; Ellerbrok H; Fleischer C; Salemi M; Reinhardt P; Ludwig WD; Vandamme AM; Pauli G; Department of Virology, Robert Koch Institut, Berlin, Germany.; In most parts of Europe only a limited number of sporadic cases of HTLV-I infections have been identified. So far, the few cases found in Germany have always been linked to individuals with relations to endemic areas. Here we report the first HTLV-I infection from a German ATL pat
Molecular epidemiological analysis of human immunodeficiency virus type 1 in Newfoundland, Canada.: AIDS Res Hum Retroviruses. 1998 Sep 1;14(13):1205-9. Unique Identifier : AIDSLINE MED/98407610; Montpetit ML; Ratnam S; Campbell C; Gleeson T; Donovan C; Tollefson J; National Laboratory for HIV Genetics, Bureau of HIV/AIDS and; STDs, Laboratory Centre for Disease Control, Health Canada,; Ottawa, Ontario.
Long-term nonprogression in HIV infection: methodological issues and scientific priorities. Report of an international European community-National Institutes of Health Workshop, The Royal Society, London, England, November 27-29, 1995. Scientific Coordinating Committee.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1211-28. Unique Identifier : AIDSLINE MED/98435933; Easterbrook PJ; Schrager LK; HIV Epidemiology Unit, Imperial College School of Medicine,; Chelsea and Westminster Hospital, London, UK.
Association between a defective CCR-5 gene and progression to disease in HIV infection.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1229-34. Unique Identifier : AIDSLINE MED/98435934; Balfe P; Churcher Y; Penny M; Easterbrook PJ; Goodall RL; Galpin S; Gotch F; Daniels RS; McKeating JA; Department of Virology, UCLMS, London, UK. p.balfe@ucl.ac.uk; We measured the effect(s) of CCR-5 genotype on disease progression by studying the frequency of a defective CCR-5 delta32 allele within a cohort of long-term infected individuals. An elevated frequency of CCR-5 delta32 heterozygotes within the cohort compared with a control population of blood donors was observed. An
Primary intestinal epithelial cells can be infected with laboratory-adapted strain HIV type 1 NDK but not with clinical primary isolates.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1235-8. Unique Identifier : AIDSLINE MED/98435935; Chenine AL; Matouskova E; Sanchez G; Reischig J; Pavlikova L; LeContel C; Chermann JC; Hirsch I; INSERM U322, Unite de Recherches sur les Retrovirus et maladies; associees, Marseille, France.; Infectivities of HIV-1 primary isolates and laboratory-adapted strains were compared in primary fetal enterocytes and the colonic epithelial cell line HT29. Infection by two laboratory strains, HIV-1 NDK and HIV-1 NDK(A4), which were adapted on CEM and HT29 cells, respectively, produced significant amounts of virus in
Potent inhibition of HIV type 1 replication by an antiinflammatory alkaloid, cepharanthine, in chronically infected monocytic cells.: Unique Identifier : AIDSLINE MED/98435936; Okamoto M; Ono M; Baba M; Division of Human Retroviruses, Center for Chronic Viral; Diseases, Faculty of Medicine, Kagoshima University, Sakuragaoka,; Japan.; Cepharanthine is a biscoclaurine alkaloid isolated from Stephania cepharantha Hayata and has been shown to have antiinflammatory, antiallergic, and immunomodulatory activities in vivo. As several inflammatory cytokines and oxidative stresses are involved in the pathogenesis of HIV-1 infection, we investigated the inhi
Replication-defective HIV as a vaccine candidate.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1247-52. Unique Identifier : AIDSLINE MED/98435937; Tung FY; Rinaldo CR Jr; Montelaro RC; Department of Infectious Disease and Microbiology, University of; Pittsburgh, Pennsylvania 15261, USA.; Live attenuated vaccines prepared from simian immunodeficiency virus (SIV) have provided the best protective immunity in challenge experiments. In animals vaccinated with attenuated SIV, immune responses may be elicited owing to endogenous expression of native SIV proteins and/or antigen presentation in the native rep
Production and characterization of SIV envelope-specific rhesus monoclonal antibodies from a macaque asymptomatically infected with a live SIV vaccine.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1253-62. Unique Identifier : AIDSLINE MED/98435938; Robinson JE; Cole KS; Elliott DH; Lam H; Amedee AM; Means R; Desrosiers RC; Clements J; Montelaro RC; Murphey-Corb M; Department of Pediatrics, Tulane University Medical School, New; Orleans, Louisiana 70112, USA.; Five rhesus monoclonal antibodies (RhMAbs) were produced by rhesus EBV transformation of peripheral blood B cells from a rhesus macaque that had been asymptomatically infected with an attenuated, macrophage-tropic SIV strain, 17E-Cl. These MAbs recognized conformation-dependent epitopes on SIV gp120 and could not be m
HIV peptide conjugated to heat-killed bacteria promotes antiviral responses in immunodeficient mice.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1263-9. Unique Identifier : AIDSLINE MED/98435939; Scott DE; Golding H; Huang LY; Inman J; Golding B; Laboratory of Plasma Derivatives, Division of Hematology, Center; for Biologics Evaluation and Research, U.S. Food and Drug; Administration, Bethesda, Maryland 20892, USA.; Enhancement of immunity in the setting of HIV infection is difficult owing to loss of functional CD4+ T cells. The MHC class II-deficient mouse (II-/-) environment simulates that of the immunocompromised HIV-infected individual, since these mice have low CD4+ T cell numbers, defective CD4-dependent responses, and are
Functional and molecular characterization of human monoclonal antibody reactive with the immunodominant region of HIV type 1 glycoprotein 41.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1271-80. Unique Identifier : AIDSLINE GENBANK/AF059200; Cavacini LA; Emes CL; Wisnewski AV; Power J; Lewis G; Montefiori D; Posner MR; Department of Medicine, Beth Israel Deaconess Medical Center and; Harvard Medical School, Boston, Massachusetts 02215, USA.; lcavacin@bidmc.harvard.edu; The immunoreactivity, functional activity, and molecular features of a human monoclonal antibody (HMAb), F240, from an HIV-1-infected individual have been studied. Flow cytometric analysis demonstrated that F240 is reactive with cells infected with a broad range of laboratory isolates but not with uninfected cells. Re
Molecular characterization of the envelope transmembrane glycoprotein of 13 new human immunodeficiency virus type 1 group O strains from six different African countries.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1281-5. Unique Identifier : AIDSLINE GENBANK/Y09780; Bibollet-Ruche F; Peeters M; Mboup S; Ekaza E; Gandji R; Torimiro J; Mpoudi EN; Amblard J; Dibanga G; Saidou M; Esu-Williams E; Vanden Haesevelde M; Saman E; Delaporte E; Project SIDAK, Laboratoire Retrovirus, ORSTOM, Montpellier,; France.
A novel glycoprotein 120 sequence from an HIV type 1 isolate of the A clade identified in North Uganda.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1287-9. Unique Identifier : AIDSLINE GENBANK/AF062521; Buonaguro L; Buonaguro FM; Russo F; Tornesello ML; Beth-Giraldo E; Wagner R; Wolf H; Giraldo G; Division of Viral Oncology and AIDS Reference Center, Istituto; Nazionale Tumori Fond. G. Pascale, Naples, Italy.
HIV type 1 C2V3 env diversity among Belgian individuals.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1291-6. Unique Identifier : AIDSLINE +; Heyndrickx L; Janssens W; Coppens S; Vereecken K; Willems B; Fransen K; Colebunders R; Vandenbruaene M; van der Groen G; Department of Microbiology, Institute of Tropical Medicine,; Antwerp, Belgium.
The subtypes of HIV type 1 in Greece.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1297-8. Unique Identifier : AIDSLINE GENBANK/AJ224956; Papa A; Adwan G; Kouidou S; Clewley JP; Alexiou S; Malisiovas N; Ntoutsos I; Kiosses B; Antoniadis A; Department of Microbiology, School of Medicine, Aristotelian; University of Thessaloniki, Greece.
Extreme founder effect in an HIV type 1 subtype A epidemic among drug users in Svetlogorsk, Belarus.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1299-303. Unique Identifier : AIDSLINE +; Lukashov VV; Karamov EV; Eremin VF; Titov LP; Goudsmit J; Department of Human Retrovirology, Academic Medical Center,; University of Amsterdam, The Netherlands.
Treatment of HIV infection with cytoreductive agents.: AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1305-13. Unique Identifier : AIDSLINE MED/99002720; Smith C; Lilly S; Miralles GD; Department of Medicine, Duke University Medical Center, Durham,; North Carolina 27710, USA.; Advances in antiretroviral therapy have resulted in significant improvement in virological markers and clinical end points. However, studies have demonstrated that HIV can be recovered from patients in whom HIV RNA has been undetectable for prolonged periods of time, suggesting that the elimination half-life of latent
Phosphorylation of triciribine is necessary for activity against HIV type 1.: AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1315-22. Unique Identifier : AIDSLINE MED/99002721; Ptak RG; Borysko KZ; Porcari AR; Buthod JL; Holland LE; Shipman C Jr; Townsend LB; Drach JC; Department of Biologic and Materials Sciences, School of; Dentistry, University of Michigan, Ann Arbor 48109-1078, USA.; Triciribine (TCN) is a tricyclic nucleoside with known antineoplastic and antiviral activity. It is a potent and selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO. TCN is phosphorylated to its 5 -monophosph
Molecular cloning and expression of rhesus macaque and sooty mangabey interleukin 16: biologic activity and effect on simian immunodeficiency virus infection and/or replication.: AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1323-8. Unique Identifier : AIDSLINE MED/99002722; Lee ME; Adams JW; Villinger F; Brar SS; Meadows M; Bucur SZ; Lackey DA 3rd; Brice GT; Cruikshank WW; Ansari AA; Hillyer CD; Department of Pathology and Laboratory Medicine and the Winship; Cancer Center, Emory University School of Medicine, Atlanta,; Georgia 30329, USA.; Interleukin 16 (IL-16) has been shown to diminish HIV and SIV replication through inhibition of HIV and SIV mRNA transcription. To evaluate its role further, we compared IL-16 cloned from disease-susceptible rhesus macaques and disease-resistant sooty mangabeys. Recombinant rhesus macaque (rr) IL-16 was compared with
Impairment of excitatory amino acid transport in astroglial cells infected with the human immunodeficiency virus type 1.: AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1329-39. Unique Identifier : AIDSLINE MED/99002723; Kort JJ; Department of Medicine, Albany Medical College, New York 12208,; USA.; Perturbation of astrocyte functions by HIV-1 infection may contribute to the pathogenesis of AIDS dementia complex (ADC). The present study investigated the possibility that astroglial transport of glutamate and aspartate, the major excitatory amino acids (EAAs) in the mammalian ce
Lack of in vitro anti-gp160 antibody production is a correlate of nonprogression among HIV type 1-infected individuals.: AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1341-3. Unique Identifier : AIDSLINE MED/99002724; Rusconi S; Santambrogio S; Di Marco A; Colombo MC; Citterio P; Adorni F; Galli M; Istituto di Malattie Infettive e Tropicali, Universita di; Milano, Ospedale Luigi Sacco, Milan, Italy.; The aim of our study was to investigate the possible correlation of in vitro antibody production (IVAP) directed to the gp160 protein of HIV-1 with CD4+ slopes, plasma viremia, and disease progression in long-term nonprogressors (LTNPs). Nineteen subjects with a long-term nonprogressive HIV-1 infection were studied an
Mucosal antibody expression following rapid SIV(Mne) dissemination in intrarectally infected Macaca nemestrina.: AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1345-56. Unique Identifier : AIDSLINE MED/99002725; Kuller L; Thompson J; Watanabe R; Iskandriati D; Alpers CE; Morton WR; Agy MB; Washington Regional Primate Research Center, University of; Washington, Seattle 98195-7330, USA.; The early kinetics of antibody expression following transmucosal infection by SIV(Mne) were examined in several mucosal compartments in Macaca nemestrina. Five male-female pairs of macaques were inoculated intrarectally with SIV(Mne) E11S, a biological clone, and serially euthanized at 1, 2, 4, 8, and 12 weeks postino
Genital infection of female chimpanzees with human immunodeficiency virus type 1.: AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1357-67. Unique Identifier : AIDSLINE MED/99002726; Girard M; Mahoney J; Wei Q; van der Ryst E; Muchmore E; Barre-Sinoussi F; Fultz PN; Institut Pasteur, Paris, France.; To develop an animal model for mucosal HIV-1 infection, adult chimpanzees were inoculated without trauma by depositing the virus inoculum at the entrance to the cervical canal with a rigid catheter to which flexible tubing was attached. By this procedure, persistent infections were established in some chimpanzees with
Comparative analysis of humoral immune responses to HIV type 1 envelope glycoproteins in mice immunized with a DNA vaccine, recombinant Semliki Forest virus RNA, or recombinant Semliki Forest virus particles.: AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1369-77. Unique Identifier : AIDSLINE MED/99002727; Brand D; Lemiale F; Turbica I; Buzelay L; Brunet S; Barin F; Laboratoire de Virologie, EP CNRS 117, Universite Francois; Rabelais, Tours, France.; The Semliki Forest virus (SFV) system seems to be a useful new approach for generating effective immune responses against HIV-1 in animal models. We evaluated this system by comparing the humoral immune responses raised in mice immunized against the HIV-1 envelope with the SFV system, a DNA vaccine, and a recombinant
Genetic and serologic characterization of HIV type 1 prevailing in Myanmar (Burma).: AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1379-85. Unique Identifier : AIDSLINE MED/99002728; Kusagawa S; Sato H; Watanabe S; Nohtomi K; Kato K; Shino T; Thwe M; OO KY; Lwin S; Mra R; Kywe B; Yamazaki S; Takebe Y; Laboratory of Molecular Virology and Epidemiology, AIDS Research; Center, National Institute of Infectious Diseases, Tokyo, Japan.; To study the molecular epidemiology of HIV-1 spread in Myanmar and the interplay with the epidemic in surrounding Southeast Asian countries, we determined the HIV-1 subtypes prevailing in Myanmar. Thirty HIV-positive blood specimens were sampled in the capital city, Yangon, and an
Characterization of the V3 region of HIV type 1 isolates from Morocco.: AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1387-9. Unique Identifier : AIDSLINE GENBANK; Abid M; Luo CC; Sekkat S; De Latore N; Mansour H; Holloman-Candal D; Rayfield M; Benslimane A; Institute Pasteur du Maroc, Casablanca, Morocco.
Characterization of HIV type 1 gp120 V3 region sequences from Ugandan infants.: AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1391-5. Unique Identifier : AIDSLINE +; Mellquist JL; Bowman B; Kasturi L; Guay L; Kataaha P; Mmiro F; Ndugwa C; Jackson JB; Eshleman SH; Department of Pathology, Case Western Reserve University School; of Medicine, Cleveland, Ohio 44106, USA.
Clinical effects of human macrophage inflammatory protein-1 alpha MIP-1 alpha (LD78) administration to humans: a phase I study in cancer patients and normal healthy volunteers with the genetically engineered variant, BB-10010.: Eur J Cancer. 1998 Jun;34(7):1023-9. Unique Identifier : AIDSLINE MED/99066312; Marshall E; Howell AH; Powles R; Hunter MG; Edwards M; Wood LM; Czaplewski L; Puttick R; Warrington S; Boyce M; Testa N; Dexter TM; Lord BI; Millar A; CRC Department of Medical Oncology, Christie Hospital,; Manchester, U.K.; BB-10010 is a genetically engineered variant of human macrophage inflammatory protein-1 alpha (hMIP-1 alpha) with improved pharmaceutical formulation properties. Although initially described as a pro-inflammatory cytokine, it is now recognised that hMIP-1 alpha has additional effects on haemopoietic stem cell cycling
Bone and joint infections in children.: Curr Opin Rheumatol. 1998 Sep;10(5):494-7. Unique Identifier : AIDSLINE MED/98419004; Spencer CH; Department of Pediatrics, La Rabida Children's Hospital and; Research Center/University of Chicago, IL 60649, USA.; Recent reports of joint and bone infections in children have provided several new insights into prompt and accurate diagnosis of these potentially destructive processes. In the HIV era, some reports have focused specifically on musculoskeletal infections at unusual sites with unusual organisms. Other reports further d
The importance of simple/rapid assays in HIV testing.: Wkly Epidemiol Rec. 1998 Oct 16;73(42):321-6. Unique Identifier : AIDSLINE MED/99020009
The geographical distribution of Kaposi's sarcoma and of lymphomas in Africa before the AIDS epidemic.: Br J Cancer. 1998 Dec;78(11):1521-8. Unique Identifier : AIDSLINE MED/99052306; Cook-Mozaffari P; Newton R; Beral V; Burkitt DP; CRC Cancer Epidemiology Research Group, Department of Public; Health, Radcliffe Infirmary, University of Oxford, UK.; Estimated incidence rates are presented for three human immunodeficiency virus (HIV)-associated cancers [Kaposi s sarcoma (KS), Burkitt s lymphoma (BL) and other non-Hodgkin s lymphomas (NHLs)] from across the African continent, based on data collected before the HIV epidemic. Mapping of the rates and comparisons with
Can social cognitive models contribute to the effectiveness of HIV-preventive behavioural interventions? A brief review of the literature and a reply to Joffe (1996; 1997) and Fife-Schaw (1997).: Br J Med Psychol. 1998 Sep;71 ( Pt 3):297-310. Unique Identifier : AIDSLINE MED/98402260; Abraham C; Sheeran P; Orbell S; School of Social Sciences, University of Sussex, Falmer,; Brighton, UK.; A recent debate in the British Journal of Medical Psychology has considered the role of social cognitive models, such as the theory of reasoned action and the theory of planned behaviour, in understanding HIV-preventive behaviour. In this paper we clarify some of the assumptions involved in applications of social cogn
Quinolone photoallergy: photosensitivity dermatitis induced by systemic administration of photohaptenic drugs.: J Dermatol Sci. 1998 Sep;18(1):1-10. Unique Identifier : AIDSLINE MED/98418428; Tokura Y; Department of Dermatology, Hamamatsu University School of; Medicine, Japan. tokuray@hama-med.ac.jp; Quinolone antibacterial agents are well known to elicit photosensitivity as a side effect. The photoallergenicity of fluoroquinolones, the representative quinolone derivatives, is mainly derived from their photohaptenic moiety. When epidermal cells are irradiated with ultraviolet A light in the presence of fluoroquino
Search for human T-lymphotropic virus type I carriers among northeastern Chinese.: J Dermatol Sci. 1998 Sep;18(1):30-4. Unique Identifier : AIDSLINE MED/98418431; Geng L; Zai N; Xiao Y; Song F; Tanaka A; Lou H; Sonoda S; Kanzaki T; Department of Dermatology, Kagoshima University Faculty of; Medicine, Japan.; Human T-lymphotropic virus type I (HTLV-I) is thought to be the causative agent of adult T-cell leukemia/ lymphoma (ATL). This virus infection is endemic in southwestern Japan , parts of Africa and the Caribbean Islands. We examined sera of 1645 subjects of Liaoning province, northea
Bacterial translocation and T-lymphocyte populations in experimental short-bowel syndrome.: Eur J Pediatr Surg. 1998 Aug;8(4):247-50. Unique Identifier : AIDSLINE MED/98456480; Aldazabal P; Eizaguirre I; Barrena MJ; Garcia-Arenzana JM; Ariz C; Cuadrado E; Hospital Na Sa de Aranzazu, San Sebastian, Spain.; Bacterial translocation (BT) accounts in part for sepsis in short-bowel syndrome in which total parenteral nutrition (TPN) is routinely necessary. TPN per se facilitates BT and it has been suggested that decreased T-lymphocyte populations (TLP) in newborn rabbits and nude mice promote BT as well. We have tested the
Molecular cloning and sequencing of feline stromal cell-derived factor-1 alpha and beta.: Eur J Immunogenet. 1998 Aug;25(4):303-5. Unique Identifier : AIDSLINE MED/98450506; Nishimura Y; Miyazawa T; Ikeda Y; Izumiya Y; Nakamura K; Cai JS; Sato E; Kohmoto M; Mikami T; Department of Veterinary Microbiology, Graduate School of; Agricultural and Life Sciences, University of Tokyo, Japan.; The stromal cell-derived factor-1 alpha and beta (SDF-1 alpha/beta) are the ligands of fusin/CXCR4, the co-receptors of human immunodeficiency virus type 1 and the feline immunodeficiency virus. We cloned the cDNA of feline SDF-1 alpha/beta. The open reading frames of feline SDF-1 alpha/beta were 267/279 base pairs an
Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase.: Biochemistry. 1998 Nov 10;37(45):15908-17. Unique Identifier : AIDSLINE MED/99060068; Arion D; Kaushik N; McCormick S; Borkow G; Parniak MA; Lady Davis Institute for Medical Research, McGill University AIDS; Centre, Sir Mortimer B. Davis-Jewish General Hospital, Montreal,; Quebec, Canada.; The multiple mutations associated with high-level AZT resistance (D67N, K70R, T215F, K219Q) arise in two separate subdomains of the viral reverse transcriptase (RT), suggesting that these mutations may contribute differently to overall resistance. We
Skills training for pregnancy and AIDS prevention in Anglo and Latino youth [see comments]: J Adolesc Health. 1998 Sep;23(3):139-49. Unique Identifier : AIDSLINE MED/98398124; Hovell M; Blumberg E; Sipan C; Hofstetter CR; Burkham S; Atkins C; Felice M; Graduate School of Public Health, San Diego State University,; California 92182, USA.; PURPOSE: This study tested social skills training (SST), didactic training (DT), and no training (NT) on adolescents social skills for resisting peer pressure to engage in acquired immunodeficiency syndrome (AIDS) and pregnancy risk behavior. METHODS: A total of 307 Latino and Anglo youth ages 13-18 years were assign
Condom use by Hispanic and African-American adolescent girls who use hormonal contraception.: J Adolesc Health. 1998 Oct;23(4):205-11. Unique Identifier : AIDSLINE MED/98434120; Roye CF; Hunter-Bellevue School of Nursing, New York, New York 10010, USA.; PURPOSE: The purpose of the present study was to examine condom use by teens who use hormonal contraceptives [i.e., Depo-Provera, Norplant, or oral contraceptives (OCs)]. METHODS: This is a cross-sectional study of 578 Hispanic and African-American female adolescents between the ages of 12 and 21 years who came to a r
Adolescent health care experience of gay, lesbian, and bisexual young adults.: J Adolesc Health. 1998 Oct;23(4):212-20. Unique Identifier : AIDSLINE MED/98434121; Allen LB; Glicken AD; Beach RK; Naylor KE; Department of Pediatrics, School of Medicine, University of; Colorado Health Sciences Center, Denver 80262, USA.; METHODS: Subjects were 102 self-identified gay, lesbian, and bisexual youth aged 18-23 years. A confidential self-administered survey elicited demographic information, sexual orientation information, health care experiences, subjects understanding of medical confidentiality during ages 14-18 years, and their suggesti
The sexual practices of Asian and Pacific Islander high school students.: J Adolesc Health. 1998 Oct;23(4):221-31. Unique Identifier : AIDSLINE MED/98434122; Schuster MA; Bell RM; Nakajima GA; Kanouse DE; RAND, Santa Monica, California 90407-2138, USA.; PURPOSE: To describe the sexual behaviors, beliefs, and attitudes of Asian and Pacific Islander California high school students and to compare them to other racial/ethnic groups. METHODS: Data were collected from an anonymous self-administered survey of 2026 ninth to 12th graders in a Los Angeles County school distric
Polymorphisms in the human CC chemokine receptor-3 gene.: Biochim Biophys Acta. 1998 Nov 8;1442(2-3):170-6. Unique Identifier : AIDSLINE MED/99023738; Zimmermann N; Bernstein JA; Rothenberg ME; Division of Pulmonary Medicine, Allergy and Clinical Immunology,; Department of Pediatrics, Children's Hospital Medical Center,; 3333 Burnet Avenue, Cincinnati, OH 45229, USA.; CC chemokine receptor (CCR)-3 is a seven-transmembrane-spanning G-protein-coupled receptor (GPCR) that is involved in the recruitment of inflammatory cells in allergic responses and acts as a co-receptor for entry of HIV into cells. Selected polymorphisms in GPCRs have been shown to have dramatic effects on the manife
Feasibility of named antenatal HIV screening in an inner city population.: Unique Identifier : AIDSLINE MED/99046410; Dennison B; Kennedy J; Tilling K; Wolfe CD; Chrystie IL; Banatvala JE; The object of this study was to assess the resource use, feasibility, uptake and consumers perspective of introducing routine named human immunodeficiency virus (HIV) testing into an inner city hospital antenatal clinic (St Thomas Hospital, part of Guy s and St Thomas Hospital Trust). Following the introduction of a
Changing HIV infection rates and risk in an African-American community cohort.: AIDS Care. 1998 Jun;10(3):267-81. Unique Identifier : AIDSLINE MED/99046411; Brunswick AF; Flory MJ; Columbia University, New York, NY 10032, USA.; This longitudinal study of a homogeneously urban African-American community cohort drawn from the metropolitan New York area (USA) analyzed three-year change in HIV-1 antibody prevalence and self-reported risk practices separately for men and women. Specifically, risk practices reported on personal interviews and resu
Is acculturation associated with sexual risk behaviours? An investigation of HIV-positive Latino men and women.: AIDS Care. 1998 Jun;10(3):283-95. Unique Identifier : AIDSLINE MED/99046412; Marks G; Cantero PJ; Simoni JM; Department of Preventive Medicine, University of Southern; California, USA.; This cross-sectional study of 226 HIV-positive Latino men and women sampled and assessed at an outpatient HIV clinic in Los Angeles examined the associations among acculturation, use of a substance before sex, and unsafe sexual behaviour. As acculturation increased, men and women were increasingly likely to have engag
Medication adherence strategies for drug abusers with HIV/AIDS.: AIDS Care. 1998 Jun;10(3):297-312. Unique Identifier : AIDSLINE MED/99046413; Sorensen JL; Mascovich A; Wall TL; DePhilippis D; Batki SL; Chesney M; San Francisco General Hospital, USA. james@itsa.ucsf.edu; This paper describes two clinical techniques aiming to improve adherence to medications for HIV/AIDS in methadone maintenance patients. The first technique, providing on-site dispensing of antiretroviral medications, enhanced medication adherence but did not produce enduring effects beyond the time of the intervention
A qualitative investigation into an HIV outbreak among injection drug users in Vancouver, British Columbia.: AIDS Care. 1998 Jun;10(3):313-21. Unique Identifier : AIDSLINE MED/99046414; Harvey E; Strathdee SA; Patrick DM; Ofner M; Archibald CP; Eades G; O'Shaughnessy MV; St. Paul's Hospital, Vancouver, Canada.; The proportion of injection drug users (IDUs) testing positive for Human Immunodeficiency Virus (HIV) in British Columbia has increased from 3 to 7% since January 1993 (Patrick et al., 1997). We conducted a qualitative study as a first step in a case control investigation aimed at identifying risk factors associated w
Whose health is it? The views of injecting drug users with HIV infection and their professional carers.: AIDS Care. 1998 Jun;10(3):323-8. Unique Identifier : AIDSLINE MED/99046415; Carretero MD; Chiswick A; Catalan J; Neurosciences and Psychological Medicine Division, Imperial; College School of Medicine, Psychological Medicine Unit, Chelsea; and Westminster Hospital, London, UK.; The views about autonomy in medical treatment of people with HIV infection (who had acquired it via the injection of drugs) and their professional carers were investigated using a standardized self-report instrument. Forty-two patients and 61 staff were entered in the study. Patients and staff reported strong endorsem
Factors associated with changes in sex behaviour among drug users in Puerto Rico.: AIDS Care. 1998 Jun;10(3):329-38. Unique Identifier : AIDSLINE MED/99046416; Robles RR; Marrero CA; Matos TD; Colon HM; Finlinson HA; Reyes JC; Sahai H; Research Institute, Mental Health and Anti-Addiction Services; Administration, San Juan, Puerto Rico.; Despite available strategies to prevent sex risk behaviours in Puerto Rico , heterosexual transmission of HIV continues to increase. Since 1990, heterosexual contact has been the fastest growing infection risk category among the island s general population, and the primary transe
Close relationships and safer sex among HIV-infected men with haemophilia.: AIDS Care. 1998 Jun;10(3):339-54. Unique Identifier : AIDSLINE MED/99046417; Norman LR; Kennedy M; Parish K; Division of HIV/AIDS Prevention, Centers for Disease Control and; Prevention, Atlanta, GA 30333, USA.; The present study sought to inform future behavioural intervention efforts by obtaining information from HIV-positive heterosexual men with haemophilia about their attitudes towards close relationships, attitudes towards risk reduction practices, and actual risk reduction practices. HIV-infected males with haemophiliae
Subjective HIV attribution theories, coping and psychological functioning among homosexual men with HIV.: AIDS Care. 1998 Jun;10(3):355-63. Unique Identifier : AIDSLINE MED/99046418; Clement U; Schonnesson LN; Heidelberg Institute of Systemic Research, Germany.; cw8@popix.ur2.uni-heidelberg.de; Facing a traumatic event, such as being diagnosed with HIV, the individual tries to find an explanation why the traumatic event happened. One way to answer that question is through attributions. The purpose of this study was to examine subjective attribution theories for HIV (internal/self-blame, external/blaming othee
Barriers to care among persons living with HIV/AIDS in urban and rural areas.: AIDS Care. 1998 Jun;10(3):365-75. Unique Identifier : AIDSLINE MED/99046419; Heckman TG; Somlai AM; Peters J; Walker J; Otto-Salaj L; Galdabini CA; Kelly JA; Department of Psychiatry and Behavioral Medicine, Medical College; of Wisconsin, Milwaukee 53226, USA.; People living with HIV disease, particularly those in small towns and rural areas, face many barriers that prevent them from receiving important life-care services. We developed the Barriers to Care Scale (BACS) to delineate the problem severity of factors that impede care and service provision among a sample of 226 me
Knowledge and attitudes about AIDS among deaf and hard of hearing persons.: AIDS Care. 1998 Jun;10(3):377-86. Unique Identifier : AIDSLINE MED/99046420; Woodroffe T; Gorenflo DW; Meador HE; Zazove P; University of Cincinnati, Ohio.; We investigated whether the public information being dispensed about Acquired Immunodeficiency Syndrome (AIDS) reaches Deaf and Hard of Hearing (D&HH) persons to the same extent as the rest of the American population. Using a self-administered written survey, modified so that D&HH persons whose primary language
Injection drug users as social actors: a stigmatized community's participation in the syringe exchange programmes of New York City.: AIDS Care. 1998 Aug;10(4):397-408. Unique Identifier : AIDSLINE MED/99046400; Henman AR; Paone D; Des Jarlais DC; Kochems LM; Friedman SR; Chemical Dependency Institute, New York, NY 10003, USA.; In 1992, New York State Department of Health regulations provided for fully legal syringe exchange programmes in the state. The policies and procedures mandated that: Each program must seek to recruit ... for inclusion on its advisory board ... program participants ... Programs are also urged to establish other advis
The validation of statements by IDUs based on the analysis of blood traces on their used syringes.: AIDS Care. 1998 Aug;10(4):409-14. Unique Identifier : AIDSLINE MED/99046401; Menoyo C; Lamikiz E; Zulaika D; Urcelai A; Zubia I; Martinez De Pancorbo M; Basque Country AIDS Prevention and Control Plan, Department of; Health of the Basque Government, San Sebastian, Spain.; The objective of this study was to study the correlation between statements made by injecting drug users (IDUs) and the analytical observation of their used syringes, with regard to needle and syringe non-sharing and HIV serology. A survey was carried out on 137 IDUs participating in different needle exchange programm
Partner notification with HIV-infected drug users: results of formative research.: AIDS Care. 1998 Aug;10(4):415-29. Unique Identifier : AIDSLINE MED/99046402; Rogers SJ; Tross S; Doino-Ingersol J; Weisfuse I; Academy for Educational Development (AED), Washington DC 20037,; USA.; The authors conducted formative research on the use of partner notification with HIV-infected drug users (i.e. those who use/abuse injectable drugs, crack or cocaine) in order to guide the development of an effective intervention for this population in New York City. Structured focus group and personal interviews were
Acceptability of voluntary HIV testing with counselling in a rural village in Kagera, Tanzania.: AIDS Care. 1998 Aug;10(4):431-9. Unique Identifier : AIDSLINE MED/99046403; Killewo JZ; Kwesigabo G; Comoro C; Lugalla J; Mhalu FS; Biberfeld G; Wall S; Sandstrom A; Muhimbili University College of Health Sciences, Dar es Salaam,; Tanzania. jkillewo@muchs.ac.tz; A pilot study on acceptability of voluntary HIV testing with counselling was performed in a rural village in Kagera, Tanzania as a potential intervention against HIV transmission. Village residents were prepared by their leaders and subsequently invited to health education group
Occupational risk of HIV infection among western health care professionals posted in AIDS endemic areas.: AIDS Care. 1998 Aug;10(4):441-52. Unique Identifier : AIDSLINE MED/99046404; de Graaf R; Houweling H; van Zessen G; Netherlands Institute of Mental Health and Addiction, Utrecht,; The Netherlands.; In this study on occupational risks of HIV infection among 99 Dutch medics working in AIDS endemic areas, 61% reported percutaneous exposures during an average stay of 21 months. The mean number of injuries was lower among physicians (2.0 versus 3.9 per year) and higher among nurses (1.9 versus 1.2) than in previous r
Health service utilization in London's African migrant communities: implications for HIV prevention.: AIDS Care. 1998 Aug;10(4):453-62. Unique Identifier : AIDSLINE MED/99046405; McMunn AM; Mwanje R; Paine K; Pozniak AL; Academic Department of Genitourinary Medicine, King's College; School of Medicine & Dentistry, London, UK.; The objective of this study was to examine health service utilization in relation to HIV/AIDS prevention in Ugandan migrants living in southeast London. A cross-sectional survey was carried out, with face-to-face interviews using a semi-structured questionnaire about knowledge and use of health services, receipt of he
Sexual HIV risk behaviour among men who have sex with both men and women.: AIDS Care. 1998 Aug;10(4):463-71. Unique Identifier : AIDSLINE MED/99046406; Weatherburn P; Hickson F; Reid DS; Davies PM; Crosier A; University of Portsmouth, London, UK.; The aim of this study was to describe the sexual behaviour of men who had sex with both men and women in the preceding five years (behaviourally bisexual men), specifically to examine their needs in relation to HIV prevention. Anonymous telephone interviews were carried out with respondents recruited though advertisem
HIV infection among foreign people involved in HIV-related risk activities and attending an HIV reference centre in Rome: the possible role of counselling in reducing risk behaviour.: AIDS Care. 1998 Aug;10(4):473-80. Unique Identifier : AIDSLINE MED/99046407; Spizzichino L; Casella P; Zaccarelli M; Rezza G; Venezia S; Gattari P; Drug Treatment Centre RM/E, Santo Spirito Hospital, Rome, Italy.; Between September 1993 and December 1995, 528 foreign individuals at risk of HIV infection attended the drug treatment centre located in the Santo Spirito Hospital in Rome, undergoing medical examination, HIV testing and counselling. The geographic distribution showed that the majority of the participants were from So
The integration of informal care, case management and community-based services for persons with HIV/AIDS.: AIDS Care. 1998 Aug;10(4):481-503. Unique Identifier : AIDSLINE MED/99046408; London AS; LeBlanc AJ; Aneshensel CS; Department of Sociology, Kent State University, Ohio 44242-0001,; USA. alondon@kent.edu; This research examines the integration of informal and formal care for persons with HIV/AIDS. Data come from a panel survey of informal HIV/AIDS caregivers (N = 642) and are analyzed using a modified version of the Behavioral Model that allows for inclusion of predisposing, enabling and need characteristics of persons
Transgender HIV prevention: a qualitative needs assessment.: AIDS Care. 1998 Aug;10(4):505-25. Unique Identifier : AIDSLINE MED/99046409; Bockting WO; Robinson BE; Rosser BR; Department of Family Practice and Community Health, Medical; School, University of Minnesota, USA. bockt001@gold.tc.umn.edu; Although clinical experience and preliminary research suggest that some transgender people are at significant risk for HIV, this stigmatized group has so far been largely ignored in HIV prevention. As part of the development of HIV prevention education targeting the transgender population, focus groups of selected tra
Managing HIV among serodiscordant heterosexual couples: serostatus, stigma and sex.: AIDS Care. 1998 Oct;10(5):533-48. Unique Identifier : AIDSLINE MED/99046391; van der Straten A; Vernon KA; Knight KR; Gomez CA; Padian NS; Center for AIDS Prevention Studies, University of California San; Francisco 94105, USA. avdstraten@psg.ucsf.edu; A qualitative study was conducted with 28 men and women in HIV-serodiscordant couples to explore the management of HIV in their relationship. Content analysis of the interviews revealed the role of serostatus and stigma in shaping partners experience of HIV, sex and risk. Partners differing serostatus often created
Factors associated with HIV-infected women's delay in seeking medical care.: AIDS Care. 1998 Oct;10(5):549-62. Unique Identifier : AIDSLINE MED/99046392; Raveis VH; Siegel K; Gorey E; Columbia University, School of Public Health, Division of; Sociomedical Sciences, New York, NY 10032, USA. vhr1@columbia.edu; Data from an investigation of HIV-infected African-American, Puerto Rican and non-Hispanic white women s treatment behaviour and decision-making are presented. Findings are based on a thematic analysis of the narrative accounts of 31 women who exhibited significant delay in seeing a physician about their HIV infection
HIV testing for HIV prevention: a comparative analysis of policies in Britain, Hungary and Sweden.: AIDS Care. 1998 Oct;10(5):563-70. Unique Identifier : AIDSLINE MED/99046393; Danziger R; Health Services Research Unit, London School of Hygiene and; Tropical Medicine, UK. r.danziger@lshtm.ac.uk; This paper compares policies on named HIV testing in the context of HIV prevention in Britain, Hungary and Sweden , and considers the extent to which these policies are based on evidence of effect
Sexual and reproductive health among primary and secondary school pupils in Mwanza, Tanzania: need for intervention.: AIDS Care. 1998 Oct;10(5):571-82. Unique Identifier : AIDSLINE MED/99046394; Matasha E; Ntembelea T; Mayaud P; Saidi W; Todd J; Mujaya B; Tendo-Wambua L; African Medical & Research Foundation (AMREF), Mwanza, Tanzania.; A cross-sectional questionnaire survey was conducted among 892 randomly selected pupils, aged 12 and above, attending 18 primary schools (PS) and five secondary schools (SS) in four communities of Mwanza Region in Tanzania . The goals were to assess the level of knowledge adolesce
AIDS-related illness trajectories in Mexico: findings from a qualitative study in two marginalized communities.: AIDS Care. 1998 Oct;10(5):583-98. Unique Identifier : AIDSLINE MED/99046395; Castro R; Orozco E; Eroza E; Manca MC; Hernandez JJ; Aggleton P; Centro Regional de Investigaciones Multidisciplinarias/UNAM,; Cuernavaca, Mexico. rcastro@servidor.unam.mx; This paper describes findings from a recent study examining how people affected directly and indirectly by the HIV/AIDS epidemic cope with HIV-related illness in Mexico. One-hundred-and-thirteen in-depth interviews were conducted with key informants in two contrasting communities: Ciudad Netzahualcoyotl (an economical
HIV serostatus disclosure among gay and bisexual men in four American cities: general patterns and relation to sexual practices.: AIDS Care. 1998 Oct;10(5):599-610. Unique Identifier : AIDSLINE MED/99046396; Wolitski RJ; Rietmeijer CA; Goldbaum GM; Wilson RM; Behavioral Intervention Research Branch, Centers for Disease; Control and Prevention, Atlanta, GA 30333, USA. rywl@cdc.gov; The present study examined patterns of serostatus disclosure among previously untested HIV-seropositive and HIV-seronegative gay and bisexual men recruited from four American cities (n = 701). Six months after learning their HIV serostatus, 97% of study participants had disclosed their test results to at least one oth
Reducing financial barriers to HIV-related medical care: does the Ryan White CARE Act make a difference?: AIDS Care. 1998 Oct;10(5):611-6. Unique Identifier : AIDSLINE MED/99046397; Marx R; Chang SW; Park MS; Katz MH; San Francisco Department of Public Health AIDS Office, California; 94102-6033, USA. rani_marx@dph.sf.ca.us; We evaluated whether the Ryan White CARE Act, which funds medical care and supportive services for low-income HIV-infected persons, equalizes health service use in San Francisco. Clients at nine CARE (n = 300) and four non-CARE (n = 172) funded sites completed self-administered questionnaires. There were no significan
Is access to medical care associated with receipt of HIV testing and counselling?: AIDS Care. 1998 Oct;10(5):617-28. Unique Identifier : AIDSLINE MED/99046398; Mosen DM; Wenger NS; Shapiro MF; Andersen RM; Cunningham WE; Department of Medicine, School of Medicine, University of; California, Los Angeles 90095, USA.; Lack of timely HIV testing leads to missed prevention opportunities and poor prevention counselling may be related to further disease spread. We examined the association of self-reported access to medical care with receiving HIV testing and preventive counselling services among a sample of patients with HIV disease pr
Impact of diarrhoea and faecal incontinence on the daily life of HIV-infected patients.: AIDS Care. 1998 Oct;10(5):629-37. Unique Identifier : AIDSLINE MED/99046399; Snijders F; de Boer JB; Steenbergen B; Schouten M; Danner SA; van Dam FS; Division of Infectious Diseases, Tropical Medicine and AIDS,; Academic Medical Center, University of Amsterdam, The; Netherlands.; Diarrhoea in HIV-1 infected persons is an important clinical problem. To improve care and counselling, information about the way, and the extent to which, diarrhoea influences the daily life of these patients can be useful. A cross-sectional descriptive study was performed at the HIV infection clinic of three major ho
Cancer in AIDS.: Curr Opin Oncol. 1998 Sep;10(5):B160-3. Unique Identifier : AIDSLINE MED/99016505
AIDS-related malignancies [editorial]: Curr Opin Oncol. 1998 Sep;10(5):403-4. Unique Identifier : AIDSLINE MED/99016491; Scadden DT
Kaposi's sarcoma herpesvirus as a new paradigm for virus-induced oncogenesis.: Curr Opin Oncol. 1998 Sep;10(5):405-12. Unique Identifier : AIDSLINE MED/99016492; Whitby D; Boshoff C; Chester Beatty Laboratories, Institute of Cancer Research,; London, UK.; Seroepidemiologic studies show that Kaposi s sarcoma herpesvirus (KSHV) is more prevalent in those populations at higher risk to develop Kaposi s sarcoma (KS). Anti-KSHV antibody titer is also higher in those who develop KS. KSHV is a sexually transmitted disease among homosexual men, but other routes of transmission
Emerging treatments for epidemic (AIDS-related) Kaposi's sarcoma.: Curr Opin Oncol. 1998 Sep;10(5):413-21. Unique Identifier : AIDSLINE MED/99016493; McGarvey ME; Tulpule A; Cai J; Zheng T; Masood R; Espina B; Arora N; Smith DL; Gill PS; University of Southern California, Los Angeles Department of; Medicine and Pathology, Norris Cancer Hospital and Research; Institute 90033, USA.; Kaposi s sarcoma (KS) is an opportunistic tumor that develops with increased frequency (100,000-fold) after HIV infection. KS causes significant morbidity from mucocutaneous involvement and mortality from complications of visceral sites of disease such as the lungs, gastrointestinal tract, and the liver. Progressive u
Advances and future challenges in non-Hodgkin's lymphoma.: Curr Opin Oncol. 1998 Sep;10(5):422-7. Unique Identifier : AIDSLINE MED/99016494; Klencke B; Kaplan L; University of California, San Francisco, Mount Zion Cancer; Center, San Francisco 94115, USA.; The mortality and morbidity burden of Non-Hodgkin s lymphoma (NHL) is increasing within the human immunodeficiency virus- (HIV-) infected population. Recent improvements in HIV management has meant overall reductions in deaths, especially those due to opportunistic infections, and while the outcome of HIV-related NHL
Anti-HIV type 1 activity of wild-type and functional defective RANTES intrakine in primary human lymphocytes.: Hum Gene Ther. 1998 Sep 20;9(14):2005-18. Unique Identifier : AIDSLINE MED/98430728; Yang AG; Zhang X; Torti F; Chen SY; Department of Cancer Biology, Comprehensive Cancer Center, Wake; Forest University School of Medicine, Winston-Salem, NC 27157,; USA.; We have developed a genetic intrakine strategy to inactivate the CC-chemokine receptor 5 (CCR-5), the principal coreceptor for macrophage (M)-tropic HIV-1 viruses (Yang et al, 1997). The inactivation of CCR5 was achieved by targeting a modified CC-chemokine (RANTES) to the lumen of the endoplasmic reticulum (ER) to
Synthetic neoglycolipids for biological applications: correlation between their structures and their interactions with membrane proteins.: Biochimie. 1998 May-Jun;80(5-6):483-7. Unique Identifier : AIDSLINE MED/98455708; Rico-Lattes I; Gouzy MF; Andre-Barres C; Guidetti B; Lattes A; Laboratoire des IMRCP, UMR-CNRS 5623, Universite Paul-Sabatier,; Toulouse, France.; Synthetic glycolipids are of interest for their biological applications requiring interactions with membrane proteins. Depending on their structures, new series of glycolipids have applications in extraction of membrane proteins or medical applications as mimics of natural ligands of proteins.
Type-specific serological testing for herpes simplex infection.: Int J STD AIDS. 1998 Sep;9(9):497-500. Unique Identifier : AIDSLINE MED/98435961; Kinghorn GR; Department of Genitourinary Medicine, Royal Hallamshire Hospital,; Sheffield, UK.
Sexually transmitted organisms in children and child sexual abuse.: Int J STD AIDS. 1998 Sep;9(9):501-10; quiz 510-1. Unique Identifier : AIDSLINE MED/98435962; Robinson AJ; Department of Genitourinary Medicine, Mortimer Market Centre,; London, UK.
Financing HIV service provision in England: estimated impact of the cost of antiretroviral combination therapy.: Int J STD AIDS. 1998 Sep;9(9):512-7. Unique Identifier : AIDSLINE MED/98435963; Beck EJ; Tolley K; Department of Epidemiology and Public Health, Imperial College; School of Medicine at St Mary's, London, UK.; The objective of this study was to provide population-based estimates on the cost of HIV service provision in England and the use of dual or triple antiretroviral combination therapy . Contemporary cost estimates of treating HIV-infected individuals by clinical stage of
Bronchopulmonary Kaposi's sarcoma in 106 HIV-1 infected patients.: Int J STD AIDS. 1998 Sep;9(9):518-25. Unique Identifier : AIDSLINE MED/98435964; Hannon FB; Easterbrook PJ; Padley S; Boag F; Goodall R; Phillips RH; Department of Radiotherapy and Oncology, Chelsea and Westminster; Hospital, London, UK.; The objectives of this study were to describe the clinical and radiological features at presentation, and the natural history of HIV-related bronchopulmonary Kaposi s sarcoma. A retrospective review of medical records and chest radiographs was performed in 106 HIV-infected homosexual men with bronchopulmonary Kaposi s
Vulvovaginal candidiasis in female sex workers.: Int J STD AIDS. 1998 Sep;9(9):526-30. Unique Identifier : AIDSLINE MED/98435965; Otero L; Palacio V; Carreno F; Mendez FJ; Vazquez F; Service of Microbiology, Hospital of Cabuenes, Gijon, Spain.; Vulvovaginal candidiasis is a frequent inflammatory process in women but it has not been widely studied in female sex workers (FSWs). To estimate the frequency of Candida species infection in FSWs and to identify related risk factors and clinical findings, we carried out a retrospective study of 1923 FSWs over 11 year
Clinical and in situ cellular responses to Haemophilus ducreyi in the presence or absence of HIV infection.: Int J STD AIDS. 1998 Sep;9(9):531-6. Unique Identifier : AIDSLINE MED/98435966; King R; Choudhri SH; Nasio J; Gough J; Nagelkerke NJ; Plummer FA; Ndinya-Achola JO; Ronald AR; Department of Medical Microbiology, University of Nairobi, Kenya,; Africa.; We aimed to determine if the clinical and histological features of chancroid are altered by HIV infection. Male patients presenting to the Nairobi special treatment clinic with a clinical diagnosis of chancroid were eligible for the study. A detailed history, physical examination, swabs for Haemophilus ducreyi culture
Efficacy of surgical and/or podophyllotoxin treatment against flat acetowhite penile human papillomavirus associated lesions.: Int J STD AIDS. 1998 Sep;9(9):537-42. Unique Identifier : AIDSLINE MED/98435967; Wikstrom A; von Krogh G; Department of Dermatovenereology, Karolinska Hospital, Stockholm,; Sweden.; In order to investigate the efficacy of treatment modalities favoured by us against flat acetowhite penile human papillomavirus (HPV)-induced lesions, we studied retrospectively standardized medical records of 81 men who had been treated for this condition. The patients were treated surgically with diathermy (n=32) or
Emergency unit care of sexually transmitted infections.: Int J STD AIDS. 1998 Sep;9(9):543-4. Unique Identifier : AIDSLINE MED/98435968; Jarvis RR; Jebakumar S; Bhattacharyya MN; Mackway-Jones K; Department of Genitourinary Medicine, Manchester Royal Infirmary,; UK. rani.jarvis@btinternet.com; The aim of the study was to assess provisions for management of sexually transmitted infections (STIs), emergency contraception and pregnancy test in UK emergency departments. Postal questionnaires were sent to all consultant-led emergency departments in the UK in January 1996. The response rate was 64%. Most departme
Cytomegalovirus pp65 antigenaemia as an indicator of end-organ disease in AIDS.: Int J STD AIDS. 1998 Sep;9(9):545-7. Unique Identifier : AIDSLINE MED/98435969; Fox EF; Smith NA; Rice P; Dunn H; Peters BS; Department of Genitourinary Medicine, Guy's and St Thomas'; Hospital, London, UK.; We aim to assess the usefulness of the cytomegalovirus ( CMV ) pp65 antigenaemia test, also called the CMV direct antigen test (DAT), in the management of patients with advanced human immunodeficiency virus (HIV) infection; we
HIV infection and asymptomatic sexually transmitted infections in a rural South African community.: Int J STD AIDS. 1998 Sep;9(9):548-50. Unique Identifier : AIDSLINE MED/98435970; Colvin M; Abdool Karim SS; Connolly C; Hoosen AA; Ntuli N; Centre for Epidemiological Research in South Africa, Medical; Research Council, Congella.; The objective was to determine the prevalence of HIV and other sexually transmitted infections (STIs) in a rural community. A population-based survey of adults in 110 homesteads was conducted in 1995. A questionnaire on demographics, sexual practices and history of STDs was administered. Neisseria gonorrhoeae and Chla
The availability and cost of antibiotics for treating PID in the Central Region of Ghana and implications for compliance with national treatment guidelines.: Int J STD AIDS. 1998 Sep;9(9):551-3. Unique Identifier : AIDSLINE MED/98435971; Bosu WK; Mabey D; Department of Infectious and Tropical Diseases, London School of; Hygiene and Tropical Medicine. wbosu@gha.healthnet.org; The availability and cost of antibiotics for treating pelvic inflammatory disease (PID) were assessed in 17 drug-dispensing outlets in 5 districts of the Central Region, Ghana . The outlets included the dispensaries of 2 regional and 4 district hospitals, 4 privately-owned pharmacies
Renal calculi developing de novo in a patient taking saquinavir [letter]: Int J STD AIDS. 1998 Sep;9(9):555. Unique Identifier : AIDSLINE MED/98435972; Green ST; McKendrick MW; Schmid ML; Mohsen AH; Prakasam SF
Redefining AIDS: case exemplified by Penicillium marneffei infection in HIV-infected people in Hong Kong [letter]: Int J STD AIDS. 1998 Sep;9(9):555-6. Unique Identifier : AIDSLINE MED/98435973; Wong KH; Lee SS; Chan KC; Choi T
Cervical smear: is screening of teenagers justified? [letter]: Int J STD AIDS. 1998 Sep;9(9):556-7. Unique Identifier : AIDSLINE MED/98435974; O'Mahony C
Study Site Coordinator/Research Nurse [letter]: Int J STD AIDS. 1998 Sep;9(9):557-8. Unique Identifier : AIDSLINE MED/98435975; McKernan S
[Ultrastructural aspects of lesions caused by Mycobacterium spp in AIDS]: Invest Clin. 1998 Sep;39(3):189-98. Unique Identifier : AIDSLINE MED/98453838; Parada D; Caleiras E; Estrada S; Tovar R; Garcia-Tamayo J; Unidad de Investigacion en Patologia Ultraestructural y; Biologia Molecular, Facultad de Medicina, Universidad Central de; Venezuela, Caracas.; Samples from necrotizing lesions in eight autopsy cases of AIDS were examined with transmission electron microscopy. They were selected among 35 autopsies of Mycobacterium spp infection and AIDS, and were part of a series of 230 autopsy cases of AIDS performed from 1984 to 1995 in the Anatomopathologic Institute at Ce
Influence of cell surface glycoprotein gC produced by pseudorabies virus on cytopathic effect.: J Vet Med Sci. 1998 Aug;60(8):905-9. Unique Identifier : AIDSLINE MED/98436893; Katayama S; Okada N; Ohgitani T; Kokubu T; Shimizu Y; Division of Veterinary Microbiology, Kyoto Biken Laboratories,; Japan.; The wild-type pseudorabies virus (WT-PRV) produced a round-type cytopathic effect (CPE) in PK-15 cell line of porcine kidney origin, while PRVgCs lacking in gC-transmembrane-anchor region and PRVgC-defecting in gC gene produced a syncytium-type CPE. The mouse embryo cell line (BALB/3T3 clone A31) were transfected with
Seroprevalence of Bartonella henselae and Toxoplasma gondii infections among pet cats in Kanagawa and Saitama Prefectures.: J Vet Med Sci. 1998 Sep;60(9):997-1000. Unique Identifier : AIDSLINE MED/99011991; Maruyama S; Hiraga S; Yokoyama E; Naoi M; Tsuruoka Y; Ogura Y; Tamura K; Namba S; Kameyama Y; Nakamura S; Katsube Y; Department of Veterinary Medicine, College of Bioresource; Sciences, Nihon University, Kanagawa, Japan.; Seroprevalence of Bartonella henselae and Toxoplasma gondii was investigated among 471 pet cats obtained from seven private animal hospitals in Kanagawa and Saitama Prefectures during the period from May 1994 to June 1995. Furthermore, 67 randomly selected from the 471 serum samples were examined for the feline immun
A combinatorial phage display library for the generation of specific Fab fragments recognizing human spermatozoa and inhibiting fertilizing capacity in vitro.: Biol Reprod. 1998 Nov;59(5):1180-6. Unique Identifier : AIDSLINE MED/98455447; Clayton R; Cooke ID; Partridge LJ; Moore HD; Department of Molecular Biology and Biotechnology, University of; Sheffield, Sheffield, United Kingdom.; To select a source of lymphocytes for the generation of an anti-sperm-biased combinatorial phage display library, venous blood was obtained from 34 vasovasostomy (vasectomy reversal) patients approximately 3 mo after surgery. Using a variety of immunoassays, serum was analyzed for antibodies against human spermatozoa,
Primary cutaneous aspergillosis--an emerging infection among immunocompromised patients [editorial; comment]: Clin Infect Dis. 1998 Sep;27(3):453-7. Unique Identifier : AIDSLINE MED/98442275; Walsh TJ
Entamoeba gingivalis in human immunodeficiency virus type 1-infected patients with periodontal disease.: Clin Infect Dis. 1998 Sep;27(3):471-3. Unique Identifier : AIDSLINE MED/98442278; Lucht E; Eveng~ard B; Skott J; Pehrson P; Nord CE; Department of Immunology, Microbiology, Pathology, and Infectious; Diseases, Karolinska Institute, Huddinge University Hospital,; Stockholm, Sweden.; Necrotic periodontal disease is a progressive painful oral lesion in human immunodeficiency virus type 1 (HIV-1)-infected patients, and the etiology is unknown. Earlier studies of HIV-1-infected patients have shown significant changes in the viral and fungal oral microflora. The aim of this study was to relate the occ
Diarrhea and Clostridium difficile infection in Latin American patients with AIDS. Working Group on AIDS in Peru.: Clin Infect Dis. 1998 Sep;27(3):487-93. Unique Identifier : AIDSLINE MED/98442281; Willingham FF; Ticona Chavez E; Taylor DN; Bowen AB; Crane AR; Gottlieb AL; Gayles MK; Grahn KF; Chavez Perez VM; Salas Apolinario I; Gilman RH; Department of International Health, Johns Hopkins University; School of Hygiene and Public Health, Baltimore, Maryland 21205,; USA.; Diarrhea and wasting are among the most debilitating and deadly manifestations of AIDS, yet only limited information is available regarding the etiology, clinical consequences, and immunologic effects of infection with diarrheal agents. Peruvian AIDS patients presenting with and without diarrhea were followed prospect
Microglial nodular encephalitis and ventriculoencephalitis due to cytomegalovirus infection in patients with AIDS: two distinct clinical patterns.: Clin Infect Dis. 1998 Sep;27(3):504-8. Unique Identifier : AIDSLINE MED/98442284; Grassi MP; Clerici F; Perin C; D'Arminio Monforte A; Vago L; Borella M; Boldorini R; Mangoni A; I Clinica Neurologica, Clinica di Malattie Infettive, Anatomia; Patologica-Istituto di Scienze Biomediche, Milano, Italy.; In patients with AIDS, cerebral infection due to cytomegalovirus ( CMV ) results in two distinct neuropathological patterns: microglial nodular encephalitis (MGNE) and ventriculoencephalitis (VE). In order to identify clinical
Herpes zoster and lymphopenia associated with sodium stibogluconate therapy for cutaneous leishmaniasis.: Clin Infect Dis. 1998 Sep;27(3):509-12. Unique Identifier : AIDSLINE MED/98442285; Wortmann GW; Aronson NE; Byrd JC; Grever MR; Oster CN; Infectious Disease Service, Walter Reed Army Medical Center,; Washington, D.C. 20307-5001, USA.; A review of 84 patients with cutaneous leishmaniasis treated with sodium stibogluconate (Pentostam) at our institution revealed that three had developed herpes zoster during or shortly after receiving therapy. Because zoster has been associated with depressed cellular immunity, we prospectively followed serial lymphoc
Clindamycin with primaquine vs. Trimethoprim-sulfamethoxazole therapy for mild and moderately severe Pneumocystis carinii pneumonia in patients with AIDS: a multicenter, double-blind, randomized trial (CTN 004). CTN-PCP Study Group.: Clin Infect Dis. 1998 Sep;27(3):524-30. Unique Identifier : AIDSLINE MED/98442288; Toma E; Thorne A; Singer J; Raboud J; Lemieux C; Trottier S; Bergeron MG; Tsoukas C; Falutz J; Lalonde R; Gaudreau C; Therrien R; Department of Microbiology and Infectious Diseases, Centre; Hospitalier de l'Universite de Montreal, Quebec, Canada.; This double-blind, randomized, multicenter trial compared clindamycin/primaquine (Cm/Prq) with trimethoprim-sulfamethoxazole (TMP-SMZ) as therapy for AIDS-related Pneumocystis carinii pneumonia (PCP). Forty-five patients received clindamycin (450 mg four times daily [q.i.d.]) and primaquine (15 mg of base/d); 42 recei
Cryptosporidiosis in patients with AIDS: correlates of disease and survival.: Clin Infect Dis. 1998 Sep;27(3):536-42. Unique Identifier : AIDSLINE MED/98442290; Manabe YC; Clark DP; Moore RD; Lumadue JA; Dahlman HR; Belitsos PC; Chaisson RE; Sears CL; Department of Pathology, Johns Hopkins University School of; Medicine, Baltimore, Maryland, USA.; Although 10%-15% of patients with AIDS in the United States may acquire cryptosporidium infection, little data exist on clinical or histological characteristics that differentiate clinical outcomes. A case-control study of 83 HIV-positive adult patients with cryptosporidiosis was condu
Predictive value of cytomegalovirus (CMV) antigenemia and digene hybrid capture DNA assays for CMV disease in human immunodeficiency virus-infected patients.: Clin Infect Dis. 1998 Sep;27(3):573-81. Unique Identifier : AIDSLINE MED/98442295; Walmsley S; O'Rourke K; Mortimer C; Rachlis A; Fong I; Mazzulli T; Department of Medicine, University of Toronto, Ontario, Canada.; Oral ganciclovir prophylaxis decreases the incidence of cytomegalovirus ( CMV ) disease among persons infected with the human immunodeficiency virus (HIV), but universal prophylaxis is not cost-effective. We evaluated urine and
Primary cutaneous aspergillosis in human immunodeficiency virus-infected patients: two cases and review [see comments]: Clin Infect Dis. 1998 Sep;27(3):641-3. Unique Identifier : AIDSLINE MED/98442304; Arikan S; Uzun O; Cetinkaya Y; Kocagoz S; Akova M; Unal S; Department of Microbiology and Clinical Microbiology, Hacettepe; University School of Medicine, Ankara, Turkey.
Itraconazole therapy for primary cutaneous aspergillosis in patients with AIDS [see comments]: Clin Infect Dis. 1998 Sep;27(3):643-4. Unique Identifier : AIDSLINE MED/98442305; van Burik JA; Colven R; Spach DH; Department of Medicine, University of Washington School of; Medicine, Seattle, USA.
Hepatitis A in human immunodeficiency virus-infected patients.: Clin Infect Dis. 1998 Sep;27(3):651-3. Unique Identifier : AIDSLINE MED/98442311; Wallace MR; Hill HE; Tasker SA; Miller LK; Department of Internal Medicine, Naval Medical Center, San Diego,; California, USA.
Bloody diarrhea caused by Plesiomonas shigelloides proctitis in a human immunodeficiency virus-infected patient.: Clin Infect Dis. 1998 Sep;27(3):657. Unique Identifier : AIDSLINE MED/98442315; Ahmad M; Aggarwal M; Ahmed A; Department of Medicine, Stanford University School of Medicine,; California, USA.
Clarithromycin therapy for bacillary peliosis did not prevent bacillary angiomatosis.: Clin Infect Dis. 1998 Sep;27(3):658. Unique Identifier : AIDSLINE MED/98442316; Mukunda BN; West BC; Shekar R; Department of Medicine, Meridia Huron Hospital, Cleveland, Ohio,; USA.
[Fungemia in patients with HIV infection]: An Med Interna. 1998 Oct;15(10):523-7. Unique Identifier : AIDSLINE MED/99060216; Santos J; Palacios R; Esteve A; Garcia V; Rivero A; Marquez M; Unidad de Infecciosos, Hospital Virgen de la Victoria, Malaga.; OBJECTIVE: To make an analysis of fungemia in HIV-infected patients in our hospital. PATIENTS AND METHODS: We retrospectively (1989-1997) studied all HIV-infected patients with positive blood cultures for Candida sp., Cryptococcus neoformans or any other fungal infection. RESULTS: C. neoformans was isolated in 11 pati
[Hospital detoxification unit: 4-year experience. Treatment and infections]: An Med Interna. 1998 Oct;15(10):528-30. Unique Identifier : AIDSLINE MED/99060217; Gutierrez del Rio C; Casanueva Gutierrez M; de la Fuente Garcia B; Gallo Alvaro C; Garcia-Alcalde Fernandez ML; Moris de la Tassa J; Servicio de Medicina Interna, Hospital de Cabuenes, Gijon,; Asturias.; BACKGROUND: Analysis of the main infections complications in drug-dependents and their relation between the way of consumption and sexual activity; the detoxification treatments used are taken into consideration. MATERIAL AND METHODS: We studied the patients admitted to the HDU (Hospital Detoxification Unit) between 1
Induction of antitumor cytotoxic activity using CD34+ cord blood cell-derived and irradiated tumor cell-primed dendritic cells.: Int J Hematol. 1998 Aug;68(2):169-82. Unique Identifier : AIDSLINE MED/99020516; Fujii S; Fujimoto K; Osato M; Matsui K; Takatsuki K; Kawakita M; Second Department of Internal Medicine, Kumamoto University; School of Medicine, Japan.; Dendritic cells (DCs) are the most powerful antigen-presenting cells in the immune system. They can activate immunologically naive T cells and improve the efficacy of immunotherapy against tumors. In the present study we investigated whether CD34+ cord blood cell-derived DCs are capable of inducing antitumor cytotoxic
[Study of the inhibiting effect of the molecular complex yeast RNA-tilorone on HIV-1 reproduction in vitro]: Biull Eksp Biol Med. 1998 Oct;126(10):433-5. Unique Identifier : AIDSLINE MED/99042585; Karpov AV; Antonenko SV; Barbasheva EV; Spivak NIa
Gene delivery to human B-precursor acute lymphoblastic leukemia cells.: Blood. 1998 Nov 15;92(10):3537-45. Unique Identifier : AIDSLINE MED/99025925; Mascarenhas L; Stripecke R; Case SS; Xu D; Weinberg KI; Kohn DB; Divisions of Research Immunology/Bone Marrow Transplantation and; Hematology/ Oncology, Department of Pediatrics, University of; Southern California School of Medicine, Childrens Hospital Los; Angeles, Los Angeles, CA, USA.; Autologous leukemia cells engineered to express immune-stimulating molecules may be used to elicit antileukemia immune responses. Gene delivery to human B-precursor acute lymphoblastic leukemia (ALL) cells was investigated using the enhanced green fluorescent protein (EGFP) as a reporter gene, measured by flow cytomet
Risk factors for adult T-cell leukemia among carriers of human T-lymphotropic virus type I.: Blood. 1998 Nov 15;92(10):3557-61. Unique Identifier : AIDSLINE MED/99025927; Hisada M; Okayama A; Shioiri S; Spiegelman DL; Stuver SO; Mueller NE; Departments of Epidemiology and Biostatistics, Harvard School of; Public Health, Boston, MA, USA. mh280i@nih.gov; The presence of circulating flower cells and a low prevalence of antibody to Tax regulatory protein of human T-lymphotropic virus type I (HTLV-I) are characteristics of adult T-cell leukemia (ATL). To examine the predictability of levels of HTLV-I antibodies and of flower cell-like abnormal lymphocytes (Ably) for th
Possible role of interleukin-10 (IL-10) and CD40 ligand expression in the pathogenesis of hypergammaglobulinemia in human immunodeficiency virus infection: modulation of IL-10 and Ig production after intravenous Ig infusion.: Blood. 1998 Nov 15;92(10):3721-9. Unique Identifier : AIDSLINE MED/99025946; Muller F; Aukrust P; Nordoy I; Froland SS; Section of Clinical Immunology and Infectious Diseases, Medical; Department A and Research Institute for Internal Medicine,; University of Oslo, The National Hospital, Rikshospitalet, Oslo,; Norway.; The mechanisms leading to polyclonal hypergammaglobulinemia in patients with human immunodeficiency virus (HIV) infection are not well understood. In light of the important role of interleukin-10 (IL-10) and the interaction between CD40 and CD40 ligand in the normal regulation of B-lymphocyte function and Ig productio
Immunostimulatory CpG oligodeoxynucleotides enhance the immune response to vaccine strategies involving granulocyte-macrophage colony-stimulating factor.: Blood. 1998 Nov 15;92(10):3730-6. Unique Identifier : AIDSLINE MED/99025947; Liu HM; Newbrough SE; Bhatia SK; Dahle CE; Krieg AM; Weiner GJ; University of Iowa Interdisciplinary Graduate Program in; Immunology, University of Iowa Department of Internal Medicine,; University of Iowa Cancer Center, USA.; Immunostimulatory oligodeoxynucleotides containing the CpG motif (CpG ODN) can activate various immune cell subsets and induce production of a number of cytokines. Prior studies have demonstrated that both CpG ODN and granulocyte-macrophage colony-stimulating factor (GM-CSF) can serve as potent vaccine adjuvants. We u
Semiquantitative Epstein-Barr virus polymerase chain reaction analysis of peripheral blood from organ transplant patients and risk for the development of lymphoproliferative disease.: Blood. 1998 Nov 15;92(10):3977-8. Unique Identifier : AIDSLINE MED/99076956; Lucas KG; Filo F; Heilman DK; Lee CH; Emanuel DJ
Virological and immunological features of long-term human immunodeficiency virus-infected individuals who have remained asymptomatic compared with those who have progressed to acquired immunodeficiency syndrome.: Blood. 1998 Nov 1;92(9):3105-14. Unique Identifier : AIDSLINE MED/99005336; Barker E; Mackewicz CE; Reyes-Teran G; Sato A; Stranford SA; Fujimura SH; Christopherson C; Chang SY; Levy JA; Department of Medicine, University of California, San Francisco,; USA.; Infection with the human immunodeficiency virus (HIV) leads to a decrease in CD4(+) T cells and disease progression within a decade of seroconversion. However, a small group of infected people, despite being infected by HIV for 10 or more years, remain clinically asymptomatic and have stable CD4(+) cell counts without
Expansion of Philadelphia chromosome-negative CD3(+)CD56(+) cytotoxic cells from chronic myeloid leukemia patients: in vitro and in vivo efficacy in severe combined immunodeficiency disease mice.: s/IMMUNOLOGY Transplantation, Homologous/IMMUNOLOGY Tumor Cells, Cultured Tumor Necrosis Factor/BIOSYNTHESIS Tumor Stem Cell Assay Tumor Stem Cells/DRUG EFFECTS Blood. 1998 Nov 1;92(9):3318-27. Unique Identifier : AIDSLINE MED/99005360; Hoyle C; Bangs CD; Chang P; Kamel O; Mehta B; Negrin RS; Division of Bone Marrow Transplantation, Department of Medicine;; the Department of Pathology, Stanford University Medical School,; Stanford, CA, USA.
OX40 costimulation enhances interleukin-4 (IL-4) expression at priming and promotes the differentiation of naive human CD4(+) T cells into high IL-4-producing effectors.: Blood. 1998 Nov 1;92(9):3338-45. Unique Identifier : AIDSLINE MED/99005362; Ohshima Y; Yang LP; Uchiyama T; Tanaka Y; Baum P; Sergerie M; Hermann P; Delespesse G; University of Montreal, Centre de Recherche Louis-Charles Simard,; Notre-Dame Hospital, and the Department of Obstetrics and; Gynecology, Montreal, Quebec, Canada.; Th2 cell development is critically dependent on the presence of interleukin-4 (IL-4) at priming. The cellular origin and the mechanisms regulating this early production of IL-4 at the site of naive T-cell priming are extensively investigated. We previously reported that anti-CD3-activated and CD28-costimulated naive h
Alloantigen-stimulated anti-HIV activity.: Blood. 1998 Nov 1;92(9):3346-54. Unique Identifier : AIDSLINE MED/99005363; Pinto LA; Sharpe S; Cohen DI; Shearer GM; Experimental Immunology Branch and Laboratory of Tumor Cell; Biology, National Cancer Institute, National Institutes of; Health, Bethesda, MD, USA.; A number of studies have suggested that an immune response to human leukocyte antigen (HLA) alloantigens may contribute to protection against HIV infection. In the present study, we examined the effect of alloantigen-stimulated cell lines obtained from peripheral blood mononuclear cells (PBMC) of HIV-uninfected (HIV-)
Absence of a correlation between Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) and multiple myeloma [letter]: Blood. 1998 Nov 1;92(9):3474-5. Unique Identifier : AIDSLINE MED/99005381; Schonrich G; Raftery M; Schnitzler P; Rohr U; Goldschmidt H
Human herpesvirus-8 and relatives of patients with plasmocytic diseases [letter]: Blood. 1998 Nov 1;92(9):3488. Unique Identifier : AIDSLINE MED/99005389; Jaccard A; Touati M; Sol C; Bordessoule D; Couty JP; Rogez S; Trimoreau F
Lentiviruses as gene transfer agents for delivery to non-dividing cells.: Curr Opin Biotechnol. 1998 Oct;9(5):457-63. Unique Identifier : AIDSLINE MED/99038713; Naldini L; Cell Genesys, Foster City, CA, USA. luigin@cellgenesys.com; Lentiviral vectors are proving to be effective agents for the direct delivery and sustained expression of a transgene in several tissues, including brain, retina, muscle and liver. Significant progress was achieved in the biosafety of HIV-derived vectors by eliminating all the viral sequences non-essential for transdu
Treatment of acyclovir-resistant herpetic ulceration with topical foscarnet and antiviral sensitivity analysis.: Dermatology. 1998;197(3):278-80. Unique Identifier : AIDSLINE MED/99030176; Pechere M; Wunderli W; Trellu-Toutous L; Harms M; Saura JH; Krischer J; Department of Dermatology, DHURDV, University Hospital, Geneva,; Switzerland.; BACKGROUND: Herpes simplex virus (HSV) can produce persistent mucocutaneous disease in patients with the acquired immunodeficiency syndrome (AIDS). In this case report, we evaluate the efficacy, safety and viral resistance after topical foscarnet in severe genital ulceration due to acyclovir-resistant HSV-2. CASE REPO
Norwegian scabies in a patient with acquired immunodeficiency syndrome.: Dermatology. 1998;197(3):306-8. Unique Identifier : AIDSLINE MED/99030183; Guggisberg D; de Viragh PA; Constantin C; Panizzon RG; Service de Dermatologie, Centre Hospitalier Universitaire; Vaudois, Lausanne, et Departement Hospitalo-Universitaire Romand; de Dermatologie et Venereologie (DHURDV), Lausanne/Geneve,; Suisse.; We report the case of a 42-year-old man with symptomatic HIV infection (C3 CDC stage) who presented widespread hyperkeratotic skin lesions diagnosed as Norwegian scabies. The CD4 count was 87 cells/mm3. The patient has been the source of a nosocomial outbreak (20 individuals affected). He was treated successfully with
Gynecomastia with stavudine treatment in an HIV-positive patient [letter]: Ann Pharmacother. 1998 Oct;32(10):1108. Unique Identifier : AIDSLINE MED/99010022; Melbourne KM; Brown SL; Silverblatt FJ
Global issues in pediatric nutrition: AIDS.: Nutrition. 1998 Oct;14(10):767-70. Unique Identifier : AIDSLINE MED/99001537; Ball CS; Department of Child Health, King's College Hospital, London, UK.; Nutrition is a final common pathway in chronic disease, and weight loss is a major manifestation of acquired immunodeficiency syndrome (AIDS). In sub-Saharan Africa, studies have shown that 25% of children with malnutrition have human immunodeficiency virus (HIV) infection, although patterns of malnutrition are indist
Resting energy expenditure and nitrogen balance in critically ill pediatric patients on mechanical ventilation.: Nutrition. 1998 Sep;14(9):649-52. Unique Identifier : AIDSLINE MED/98433291; Coss-Bu JA; Jefferson LS; Walding D; David Y; Smith EO; Klish WJ; Department of Pediatrics, Baylor College of Medicine, Houston,; Texas, USA. jcossbu@msmailpo2.is5.tch.tmc.edu; Nutritional support is important in critically ill patients, with variable energy and nitrogen requirements (e.g., sepsis, trauma, postsurgical state) in this population. This study investigates how age, severity of illness, and mechanical ventilation are related to resting energy expenditure (REE) and nitrogen balanc
Bioelectrical impedance analysis in human immunodeficiency virus-infected patients: comparison of single frequency with multifrequency, spectroscopy, and other novel approaches [see comments]: Nutrition. 1998 Sep;14(9):658-66. Unique Identifier : AIDSLINE MED/98433293; Paton NI; Elia M; Jennings G; Ward LC; Griffin GE; St. George's Hospital Medical School, London, United Kingdom.; Bioelectrical impedance (BIA), a prediction method for estimating body water compartments and body cell mass (BCM), is being increasingly used in studies of human immunodeficiency virus (HIV)-related wasting, but there are few validation studies of the method in this group. The aim of this study is to examine the rela
Evaluation of outcomes for patients with AIDS receiving home total parenteral nutrition.: Nutrition. 1998 Sep;14(9):731-5. Unique Identifier : AIDSLINE MED/98433312; Ireton-Jones CS; Stiller DL; Nutrition Program Management, Coram Healthcare, Preferred; Nutrition Therapists, Carrollton, Texas, USA.; This study evaluated the outcomes of patients with acquired immunodeficiency syndrome (AIDS) provided home total parenteral nutrition (HTPN) when specific criteria were used to initiate HTPN. Fifteen males who received HTPN and seven males who consumed only an oral diet were studied. The HTPN patients received an aver
Colony stimulating factors: G-CSFs--filgrastim (Neupogen) and lenograstim (Granocyte).: Intensive Crit Care Nurs. 1998 Feb;14(1):49-50. Unique Identifier : AIDSLINE MED/98316077; MacConnachie AM; The introduction of leucocyte growth factors produced by DNA biosynthetic technology has had a major impact on survival in patients with compromised immunity. Such agents have maximized the benefits of treatment with drugs which are otherwise potentially toxic to the bone marrow.
Hospital vs community care: a Romanian perspective.: Br J Nurs. 1998 Sep 24-Oct 7;7(17):1027-32. Unique Identifier : AIDSLINE MED/99048590; Glasper EA; Robertson L; Watkin S; University of Southampton's School of Nursing and Midwifery.; In the Summer of 1997, two Romanian charities which provide financial support to care for children with human immunodeficiency virus (HIV) living in Romania invited a team of healthcare professionals to conduct an independent audit of care for children nursed in hospital and community settings. The primary objective o
Manifestations of periodontal diseases in AIDS patients.: Braz Dent J. 1998;9(1):47-51. Unique Identifier : AIDSLINE MED/99052524; Rego TI; Pinheiro AL; Departamento de Protese e Cirurgia Buco-Facial, Universidade; Federal de Pernambuco, Recife, Brasil.; The aim of this study is to analyze periodontal diseases in AIDS patients. Although AIDS was first detected in Brazil in 1982, it is growing steadily and is more frequent in the Southeast. Oral manifestations are common and may represent early signs of the disease. These lesions of
Purification of alpha-sarcin and an antifungal protein from Aspergillus giganteus by blue sepharose CL-6B affinity chromatography.: Protein Expr Purif. 1998 Nov;14(2):295-301. Unique Identifier : AIDSLINE MED/99008945; Hao JJ; Xu Yz; Geng CD; Liu WY; Wang Ed; Gong ZZ; Ulbrich N; State Key Laboratory of Molecular Biology, Laboratory of Ribosome; Research, Laboratory of Plant Molecular Genetics, Shanghai; Institute of Biochemistry, Academia Sinica, 320 Yue-Yang Road,; Shanghai, 200031, China.; A simple method for preparation of alpha-sarcin and an antifungal protein (AFP) from the mold Aspergillus giganteus MDH 18894 has been developed. alpha-Sarcin and AFP were purified simultaneously by carboxymethylcellulose 52 cation-exchange chromatography and Blue Sepharose CL-6B affinity chromatography. By this metho
[A case of coinfection by Balantidium coli and HIV in French Guiana]: Bull Soc Pathol Exot. 1998;91(4):309-11. Unique Identifier : AIDSLINE MED/99062653; Clyti E; Aznar C; Couppie P; el Guedj M; Carme B; Pradinaud R; Service de dermatologie, Centre hospitalier de Cayenne, Guyane; francaise.; A case of balantidial dysentery is reported in a patient infected with the HIV in French Guiana . This case is the first described in medical literature. The patient presented also a disseminated histoplasmosis. Immunosuppression pro
[Efficacy of a short 6 month therapeutic coursefor HIV infected tuberculosis patients in Abidjan, Cote d'Ivoire]: Bull Soc Pathol Exot. 1998;91(4):312-4. Unique Identifier : AIDSLINE MED/99062654; Domoua K; N'Dhatz M; Coulibaly G; Traore F; Koffi J; Achi V; Daix T; Ouattara Y; Ouedraogo M; Beugre LK; Konan JB; Coulibaly V; Coulibaly IM; Yapi A; Service de pneumo-phtisiologie, CHU de Treichville, Abidjan,; Cote d'Ivoire.; From December 1992 to February 1993, 104 newly diagnosed pulmonary tuberculosis patients were enrolled in a prospective cohort study to assess the response to the 6 month-short-course regimen implemented in Cote d Ivoire . This treatment encompassed the daily intake of Rifampic
Chemoprophylaxis after definite occupational exposure to human immunodeficiency virus (HIV).: Can Fam Physician. 1998 Nov;44:2388, 2401-3. Unique Identifier : AIDSLINE MED/99056433
Diagnosing multidrug resistant tuberculosis in Britain. Clinical suspicion should drive rapid diagnosis [editorial]: BMJ. 1998 Nov 7;317(7168):1263-4. Unique Identifier : AIDSLINE MED/99023853; Drobniewski FA
Infection with HIV-1.: BMJ. 1998 Nov 7;317(7168):1297-301. Unique Identifier : AIDSLINE MED/99023867; Graham BS; A-4103 MCN, Vanderbilt University School of Medicine, 1161 21st; Avenue South, Nashville, TN 37232-2582, USA.; mcmail.vanderbilt.edu
An endogenous retrovirus with nucleic acid sequences similar to those of the multiple sclerosis associated retrovirus at the human T-cell receptor alpha, delta gene locus.: Cell Mol Biol (Noisy-le-grand). 1998 Sep;44(6):927-31. Unique Identifier : AIDSLINE GENBANK/AC002346; Alliel PM; Perin JP; Pierig R; Rieger F; Neurobiologie du Developpement Normal et Pathologique, INSERM,; IFM, Paris, France.; Retroviruses are suspected to be involved in the pathogenesis of autoimmune diseases, such as multiple sclerosis (MS). Here, we describe a complete cartography of a novel human endogenous retroviral sequence with a pol domain which shares a high homology with the pol sequence of the multiple sclerosis associated retro
'Delayed HIV sero-conversion' in an Indian male [letter]: Natl Med J India. 1998 Jul-Aug;11(4):201-2. Unique Identifier : AIDSLINE MED/99026514; Kura MM; Gharpure HM; Hira SK; Patokar B; Oberai C; Narkhede N
Anatomy of protein pockets and cavities: measurement of binding site geometry and implications for ligand design.: Protein Sci. 1998 Sep;7(9):1884-97. Unique Identifier : AIDSLINE MED/98432637; Liang J; Edelsbrunner H; Woodward C; Department of Biochemistry, University of Minnesota, St. Paul; 55108, USA.; Identification and size characterization of surface pockets and occluded cavities are initial steps in protein structure-based ligand design. A new program, CAST, for automatically locating and measuring protein pockets and cavities, is based on precise computational geometry methods, including alpha shape and discret
HIV-1 Nef protein causes death in stressed yeast cells due to determinants near the N-terminus and elsewhere in Nef.: Biochem Mol Biol Int. 1998 Oct;46(2):277-86. Unique Identifier : AIDSLINE MED/99018604; Macreadie I; Sankovich S; Failla P; Lowe M; Curtain C; Castelli L; Azad A; Biomolecular Research Institute, Parkville, Victoria, Australia.; The Human Immunodeficiency Virus type 1 (HIV-1) Nef protein is essential for AIDS pathogenesis. In order to determine more about the effects of Nef on basic cellular functions Nef was produced in yeast under a variety of conditions and in multiple cell types. Production of Nef caused cell death in acutely copper- or h
[Complications after BCG vaccination in the urban section of Lodz in the years 1994-5]: Pneumonol Alergol Pol. 1997;65(11-12):761-6. Unique Identifier : AIDSLINE MED/98433513; Pankowska A; Ro~zniecki J; Kliniki Pneumonologii i Alergologii IMW AM w Lodzi.; The purpose of this paper was to evaluate the incidence of complications after BCG vaccination in children from urban area of Lodz in 1994-1995 and to give their pathological and prognostic interpretation on the basis of immunological and Groer allergometric examinations. The obtained data demonstrate that postvaccina
Clinical aspects of Pneumocystis carinii pneumonia in HIV-infected patients: 1997.: FEMS Immunol Med Microbiol. 1998 Sep;22(1-2):103-5. Unique Identifier : AIDSLINE MED/99006532; Miller R; Department of Sexually Transmitted Diseases, University College; London Medical School, UK. rmiller@gum.ucl.ac.uk; In 1997 in Europe P. carinii pneumonia is largely a disease of individuals who are either unaware of their HIV serostatus or who decline prophylaxis despite knowing they are HIV positive. Although fibre optic bronchoscopy and bronchoalveolar lavage is the diagnostic gold standard polymerase chain reaction (PCR) ampl
Effect of a killer toxin of Pichia anomala to Pneumocystis. Perspectives in the control of pneumocystosis.: FEMS Immunol Med Microbiol. 1998 Sep;22(1-2):145-9. Unique Identifier : AIDSLINE MED/99006537; Seguy N; Polonelli L; Dei-Cas E; Cailliez JC; Dept. Microbiol. Ecosystemes, Institut Pasteur de Lille,; France. nathalie.seguy@pasteur-lille.fr; Despite the development of drugs in the prophylaxis of pneumocystosis, Pneumocystis carinii remains a major opportunistic microorganism in immunosuppressed individuals, especially in human immunodeficiency virus-infected patients. Since side effects were frequently observed after administration of trimethoprim-sulfame
Evaluation of drug efficacy by using animal models or in vitro systems.: FEMS Immunol Med Microbiol. 1998 Sep;22(1-2):173-9. Unique Identifier : AIDSLINE MED/99006541; Brun Pascaud M; Herreros E; Aliouat EM; Dei-Cas E; INSERM U13, Hopital Bichat, Paris, France.; The efficacy of most therapeutic and prophylactic protocols against Pneumocystis carinii pneumonia used in human patients has been tested in animal models, especially in the corticosteroid-treated rat. The advantages and drawbacks of this model have been examined in brief in Chapter 1 of this section. More recently, t
Pneumocystis: the 'carrier state': epidemiology and transmission of human pneumocystosis.: FEMS Immunol Med Microbiol. 1998 Sep;22(1-2):81-6. Unique Identifier : AIDSLINE MED/99006528; Latouche S; Rabodonirina M; Mazars E; Laboratoire de Parasitologie-Mycologie CHU Saint-Antoine, Paris,; France.
Emerging aspects related to the application of biomolecular techniques to the diagnosis of Pneumocystis carinii pneumonia: our experience with ITSs primers.: FEMS Immunol Med Microbiol. 1998 Sep;22(1-2):93-5. Unique Identifier : AIDSLINE MED/99006530; Atzori C; Angeli E; Agostoni F; Mainini A; Filippini M; Micheli V; Cargnel A; Department of Infectious Diseases, Sacco Hospital, Milan, Italy.
Public health. AIDS deaths drop [news]: Hosp Health Netw. 1998 Nov 20;72(22):16-7. Unique Identifier : AIDSLINE MED/99066363
Mechanism for the development of pyothorax-associated lymphoma.: Pathol Int. 1998 Sep;48(9):653-64. Unique Identifier : AIDSLINE MED/98449553; Kanno H; Aozasa K; Department of Pathology, Osaka University Medical School, Suita,; Japan. kanno@molpath.med.osaka-u.ac.jp; Malignant lymphomas frequently develop in the pleural cavity of patients with long-standing pyothorax. Thus, the term pyothorax-associated lymphoma (PAL) has been proposed for this type of tumor. Most PAL are of the type diffuse lymphoma of B cell and contain Epstein-Barr virus (EBV) DNA. This article reviews the mech
[Feasibility of following up transfused patients]: Transfus Clin Biol. 1998 Aug;5(4):266-74. Unique Identifier : AIDSLINE MED/99006395; Mathoulin-Pelissier S; Vicariot M; Courtois F; Waller C; Gross S; Verret C; Saves M; Eghbali H; Salmi LR; Centre national d'hemovigilance, Institut de sante publique; d'epidemiologie et de developpement, Bordeaux, France.; The aim of this study was to assess the natural history of patients after transfusion and the acceptability of a standardized biological follow-up. In 1995, during 1 month, in 13 French hospitals, a follow-up at 3 and 6 months after blood transfusion was proposed to all blood recipients who had not received any blood
[Prevalence of HIV, HTLV, and hepatitis B and C viruses in blood donors in France, 1992-1996]: Transfus Clin Biol. 1998 Oct;5(5):305-12. Unique Identifier : AIDSLINE MED/99053111; Pillonel J; Saura C; Courouce AM; Reseau National de Sante Publique, Saint-Maurice, France.; The prevalence of HIV, HTLV, HBV and HCV infections has been calculated by age and sex of blood donors and not, as generally done, according to the number of donations. This study has been conducted on the basis of two surveys. The first one collected information about the sex and age of the seropositive donors. A sec
Immunopathology of the small-airway submucosa in smokers with and without chronic obstructive pulmonary disease.: Am J Respir Crit Care Med. 1998 Nov;158(5 Pt 1):1518-23. Unique Identifier : AIDSLINE MED/99034737; Lams BE; Sousa AR; Rees PJ; Lee TH; Department of Allergy and Respiratory Medicine, Guy's Hospital,; London, United Kingdom.; The airflow obstruction in chronic obstructive pulmonary disease (COPD) occurs mainly at the level of the small airways. In order to investigate the effect of smoking on small-airway submucosal immunopathology, we used immunohistochemistry in peripheral lung sections obtained at surgery from a group of smokers (n = 22
Cigarette smoking in HIV infection induces a suppressive inflammatory environment in the lung.: Am J Respir Crit Care Med. 1998 Nov;158(5 Pt 1):1543-9. Unique Identifier : AIDSLINE MED/99034741; Wewers MD; Diaz PT; Wewers ME; Lowe MP; Nagaraja HN; Clanton TL; Department of Internal Medicine, College of Medicine and Public; Health, Department of Statistics College of Mathematics, Physical; Sciences, Ohio State University, Columbus, Ohio, USA.; wewers.2@osu.edu; Lung lymphocyte numbers are frequently increased in human immunodeficiency virus (HIV)-infected individuals in the absence of lung infection, and may play a critical role in viral surveillance and protection against new infections. In this context, cigarette smoking by HIV-infected individuals has been associated with
The transport of the anti-HIV drug, 2',3'-didehydro-3'-deoxythymidine (D4T), across the blood-brain and blood-cerebrospinal fluid barriers.: Br J Pharmacol. 1998 Sep;125(1):49-54. Unique Identifier : AIDSLINE MED/98447238; Thomas SA; Segal MB; Sherrington School of Physiology, U.M.D.S., St. Thomas Hospital; Campus, London.; 1. The brain is a site of infection, viral replication and sanctuary for HIV-1. The treatment of HIV-1 infection therefore requires that an effective agent be delivered to the brain. 2 ,3 -Didehydro-3 -deoxythymidine (D4T) is a nucleoside analogue which has been shown to have beneficial clinical effects in the treatme
CD8+ cytolytic T lymphocytes and the skin.: Exp Dermatol. 1998 Aug;7(4):121-31. Unique Identifier : AIDSLINE MED/98429373; De Panfilis G; Department of Dermatology, Azienda Spedali Civili, Brescia,; Italy.; T lymphocytes show a special affinity for the skin. Although the roles played by the CD4+ population of T lymphocytes in immunodermatology were so far actively investigated, much less is known about the roles played in the skin by CD8+ cytolytic T lymphocytes (CTL). The activity of CD8+ CTL in the immunodermatological
Liposomes as drug delivery system: a strategic approach for the treatment of HIV infection.: J Drug Target. 1998;6(1):1-15. Unique Identifier : AIDSLINE MED/98439953; Desormeaux A; Bergeron MG; Centre de Recherche en Infectiologie, Centre Hospitalier; Universitaire de Quebec, Quebec, Canada.; As the number of individuals infected with human immunodeficiency virus (HIV) is growing dramatically throughout the world, it is important to develop strategies to improve the treatment of this deadly disease. It is now well established that macrophages play a central role in HIV pathogenesis, acting as reservoirs fo
HIV gp120: double lock strategy foils host defences.: Structure. 1998 Aug 15;6(8):945-9. Unique Identifier : AIDSLINE MED/98416690; Sattentau QJ; Centre d'Immunologie de Marseille-Luminy, Marseille, France.; sattenta@ciml.univ-mrs.fr; The recent determination of the structure of a complex formed between the HIV-1 glycoprotein gp120, CD4 and an antibody fragment has revealed new mechanisms for viral evasion of the immune response and shed light on how the virus enters target cells. The results of this work, together with related biochemical studies,
Structure of translation initiation factor 5A from Pyrobaculum aerophilum at 1.75 A resolution.: Structure. 1998 Sep 15;6(9):1207-14. Unique Identifier : AIDSLINE PDB/1VIE; Peat TS; Newman J; Waldo GS; Berendzen J; Terwilliger TC; Life Sciences Division Los Alamos National Laboratory Mail Stop; M888, Los Alamos, New Mexico, 87545, USA peat@proi1.lanl.gov; BACKGROUND: Translation initiation factor 5A (IF-5A) is reported to be involved in the first step of peptide bond formation in translation, to be involved in cell-cycle regulation and to be a cofactor for the Rev and Rex transactivator proteins of human immunodeficiency virus-1 and T-cell leukemia virus I, respectivel
All or none peripheral tolerance induction in H-Y antigen-specific TCR transgenic mice.: Transpl Immunol. 1998 Jun;6(2):78-83. Unique Identifier : AIDSLINE MED/98450870; Sheng B; Odebralski JM; Smith RT; Department of Hematology, University of Pennsylvania,; Philadelphia, USA.; In in vivo tolerance induction, the dose of tolerogen injected is generally linearly correlated to the length of tolerance induced. Small, medium and large doses are related to no, partial and long-term tolerance, respectively. However, even with injection of substantially large doses of tolerogen, the length of toler
Immunological aspects of human schistosomiasis.: Br Med Bull. 1998;54(2):357-68. Unique Identifier : AIDSLINE MED/99047894; Butterworth AE; University of Cambridge, UK.; Helminth infections are characteristically associated with Th2-dependent responses leading to IgE production and eosinophilia. However, the effect of such responses varies between different hosts. In murine schistosomiasis, for example, Th1 responses are associated with protection against infection, and Th2 responses
The growing challenge of HIV/AIDS in developing countries.: Br Med Bull. 1998;54(2):369-81. Unique Identifier : AIDSLINE MED/99047895; Grant AD; De Cock KM; London School of Hygiene and Tropical Medicine, London, UK.; The burden of HIV infection and disease continues to increase in many developing countries. An emerging theme is of an HIV pandemic composed of mini-epidemics, each with its own characteristics in terms of the trends in HIV prevalence, those affected, and the HIV-related opportunistic diseases observed. A number of ex
Acute bacterial infections and HIV disease.: Br Med Bull. 1998;54(2):383-93. Unique Identifier : AIDSLINE MED/99047896; Gilks CF; Liverpool School of Tropical Medicine, UK.; Some acute bacterial infections, notably those caused by the pneumococcus and the non-typhi salmonellae, have not traditionally been considered as leading diseases in tropical medicine, despite their ubiquitous distribution and impact on health. The HIV/AIDS epidemic is forcing a re-evaluation of this position because
T-cell subsets: chemokine receptors guide the way.: Curr Biol. 1998 Sep 10;8(18):R646-9. Unique Identifier : AIDSLINE MED/98421148; O'Garra A; McEvoy LM; Zlotnik A; Department of Immunobiology, DNAX Research Institute, Palo Alto,; California 94304-1104, USA.; Recent results show that chemokine receptors and adhesion molecules can be differentially expressed on the different subsets of T helper cells, suggesting that regulated networks of gene expression may control tissue-specific migration of T helper cells.
HIV encephalitis, proviral load and dementia in drug users and homosexuals with AIDS. Effect of neocortical involvement.: Brain. 1998 Nov;121 ( Pt 11):2043-52. Unique Identifier : AIDSLINE MED/99043467; Bell JE; Brettle RP; Chiswick A; Simmonds P; Department of Pathology, University of Edinburgh, UK.; Jeanne.Bell@ed.ac.uk; In this consecutive autopsy study, the pathological evidence of HIV encephalitis, which included the presence of giant cells and/or HIV p24 immunopositivity, was found more frequently in drug users (25 of 45; 56%) than in homosexual men (6 of 35; 17%) with AIDS (P
Glucocorticoids interact with gp120 in causing neurotoxicity in striatal cultures.: Brain Res. 1998 Oct 19;808(2):305-9. Unique Identifier : AIDSLINE MED/98440304; Iyer AM; Brooke SM; Sapolsky RM; Department of Biological Sciences, Stanford University, Stanford,; CA 94305, USA.; A significant subset of HIV-positive patients suffer from AIDS-Related Dementia Complex (ADC), an array of neurologic and neuropsychologic impairments. The HIV coat protein gp120 has been implicated in the deleterious neurologic consequences of HIV infection, damaging neurons through a glutamatergic and calcium-depend
CD30-positive anaplastic large cell lymphoma (ALCL) of T-cell lineage in a 14-month-old infant with perinatally acquired HIV-1 infection.: J Pediatr Hematol Oncol. 1998 Nov-Dec;20(6):556-9. Unique Identifier : AIDSLINE MED/99072498; Funkhouser AW; Katzman PJ; Sickel JZ; Lambert JS; Department of Pediatrics, University of Chicago, Illinois 60637,; USA.; PURPOSE: CD30-positive anaplastic large cell lymphoma (ALCL) has been described in adults with HIV-1 infection but is extremely rare in HIV-1-infected infants and children. PATIENT AND METHODS: A 14-month-old girl with congenitally acquired HIV-1 infection presented with fever and a tender, erythematous, cystic mass o
Characterization of sera from subjects infected with HIV-1 subtypes B and E in Thailand by antibody binding and neutralization.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 1;19(4):315-20. Unique Identifier : AIDSLINE MED/99049485; Louisirirotchanakul S; Beddows S; Cheingsong-Popov R; Shaffer N; Mastro TD; Auewarakul P; Likanonsakul S; Wasi C; Weber J; Department of Genito-Urinary Medicine and Communicable Diseases,; Imperial College School of Medicine at St Mary's, London, UK.; The range and specificity of the humoral immune response to HIV-1 subtypes B and E was investigated in Thai samples. Sera from HIV-1-positive subjects, consisting of subtypes B (n = 24) and E (n = 138), were characterized in relation to the neutralization of primary isolates and T-cell line-adapted (TCLA) strains and
Interleukin-10 enhances tumor necrosis factor-alpha activation of HIV-1 transcription in latently infected T cells.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 1;19(4):321-31. Unique Identifier : AIDSLINE MED/99049486; Rabbi MF; Finnegan A; Al-Harthi L; Song S; Roebuck KA; Department of Immunology/Microbiology, Rush Presbyterian St.; Luke's Medical School Chicago, Illinois, USA.; Interleukin-10 (IL-10) is elevated in HIV-1-infected individuals and has been implicated in disease progression. We previously reported that IL-10 cooperates with tumor necrosis factor-alpha (TNF-alpha) to activate HIV-1 expression synergistically in acutely infected monocyte-derived macrophages and the chronically in
Activation and proliferation of CD8+ T cells in lymphoid tissues of HIV-1-infected individuals in the absence of the high-affinity IL-2 receptor.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 1;19(4):332-8. Unique Identifier : AIDSLINE MED/99049487; Brinchmann JE; Rosok BI; Spurkland A; Institute of Transplantation Immunology, Rikshospitalet, Oslo,; Norway. j.e.brinchmann@rh.uio.no; Activation of CD8+ T cells may have important pathogenic implications in HIV-1 infection. Studies of this process have so far been confined to cells from the peripheral blood. In the present study, we have examined molecules involved in activation and proliferation of CD8+ T cells in lymphoid tissues from HIV-1-infect
A randomized, controlled, double-blind study comparing the survival benefit of four different reverse transcriptase inhibitor therapies (three-drug, two-drug, and alternating drug) for the treatment of advanced AIDS. AIDS Clinical Trial Group 193A Study Team.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 1;19(4):339-49. Unique Identifier : AIDSLINE MED/99049488; Henry K; Erice A; Tierney C; Balfour HH Jr; Fischl MA; Kmack A; Liou SH; Kenton A; Hirsch MS; Phair J; Martinez A; Kahn JO; University of Minnesota, Minneapolis, USA.; henry02@karloff.fstrf.org; OBJECTIVE: The primary objective was to compare the effects of dual or triple combinations of HIV-1 reverse transcriptase inhibitors with respect to survival. The time to new HIV disease progression or death, toxicities, the change in CD4 cells, and plasma HIV-1 RNA concentrations in a subset of study subjects were ev
Factors associated with HIV-infected patients' recognition and use of HIV medications.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 1;19(4):350-60. Unique Identifier : AIDSLINE MED/99049489; Jeffe DB; Meredith KL; Mundy LM; Fraser VJ; Division of Health Behavior Research, Washington University; School of Medicine, St. Louis, Missouri 63108, USA.; djeffe@imgate.wustl.edu; In 1996, we interviewed 224 HIV-infected patients (54% men, 63% African American) receiving HIV medical care in St. Louis, Missouri about their recognition, prior use, and current use of HIV medications. Of 221 respondents who had heard of at least one antiretroviral drug, only 2 respondents reported they had never ta
A prospective study of tuberculosis and HIV disease progression.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 1;19(4):361-6. Unique Identifier : AIDSLINE MED/99049490; Munsiff SS; Alpert PL; Gourevitch MN; Chang CJ; Klein RS; Department of Medicine, Montefiore Medical Center and the Albert; Einstein College of Medicine, Bronx, New York, USA.; muns301w@cdc.gov; OBJECTIVE: To determine whether active tuberculosis alters the rate of progression of HIV infection in dually infected patients. METHODS: HIV-seropositive patients at two Bronx, New York hospitals with tuberculosis confirmed by culture from July 1992 to February 1995, who survived the initial hospitalization for tuber
Mexiletine for HIV-infected patients with painful peripheral neuropathy: a double-blind, placebo-controlled, crossover treatment trial.: Unique Identifier : AIDSLINE MED/99049491; Kemper CA; Kent G; Burton S; Deresinski SC; Although mexiletine, an antiarrhythmic with local anesthetic properties, has been reported to relieve discomfort in diabetic neuropathy, its usefulness in the treatment of HIV-related painful peripheral neuropathy (PPN) has not been determined. The tolerance and effec
Th1/Th2 cytokine expression in saliva of HIV-positive and HIV-negative individuals: a pilot study in HIV-positive individuals with oropharyngeal candidiasis.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 1;19(4):373-80. Unique Identifier : AIDSLINE MED/99049492; Leigh JE; Steele C; Wormley FL Jr; Luo W; Clark RA; Gallaher W; Fidel PL Jr; Department of General Dentistry, Louisiana State University; Medical Center, New Orleans 70119, USA.; Current data suggest that T-helper (Th)2-type cytokine responses are often associated with progression to AIDS in HIV-positive individuals. Similarly, Th2-type cytokines are associated with susceptibility to mucosal candidiasis, of which oropharyngeal candidiasis (OPC) is one of the most common opportunistic infection
Distinctive effects of CCR5, CCR2, and SDF1 genetic polymorphisms in AIDS progression.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 1;19(4):381-6. Unique Identifier : AIDSLINE MED/99049493; Hendel H; Henon N; Lebuanec H; Lachgar A; Poncelet H; Caillat-Zucman S; Winkler CA; Smith MW; Kenefic L; O'Brien S; Lu W; Andrieu JM; Zagury D; Schachter F; Rappaport J; Zagury JF; Laboratoire de Physiologie Cellulaire, Universite Pierre et; Marie Curie, Paris, France.; The Genetics of Resistance to Infection by HIV-1 (GRIV) cohort represents 200 nonprogressor/slow-progressor (Slowprog) and 90 fast-progressor (Fastprog) HIV-1-infected patients. Using this unique assembly, we performed genetic studies on three recently discovered polymorphisms of CCR5, CCR2, and SDF1, which have been
Prophylaxis for opportunistic infections among HIV-infected patients receiving medical care.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 1;19(4):387-92. Unique Identifier : AIDSLINE MED/99049494; Sackoff J; McFarland J; Su S; Bryan E; New York City Department of Health, Office of AIDS Surveillance,; New York 10013, USA.; In 1995 and 1997, the United States Public Health Service (USPHS) and the Infectious Disease Society of America (IDSA) published recommendations for primary prophylaxis of Pneumocystis carinii pneumonia (PCP), Mycobacterium avium complex (MAC), and toxoplasmosis in HIV-infected adults.
Molecular epidemiology and trends of HIV-1 subtypes in Taiwan.: Unique Identifier : AIDSLINE MED/99049495; Chen YM; Lee CM; Lin RY; Chang HJ; AIDS Prevention and Research Center, Institute of Public Health,; School of Medicine, National Yang-Ming University, Taipei,; Taiwan, Republic of China. arthur@ym.edu.tw; To understand the trends of distribution and risk factors associated with different HIV-1 subtypes in different populations in Taiwan , blood samples and questionnaires were collected from 267 male and 21 female HIV-1-infected people
Gender and survival after AIDS in Rio de Janeiro, Brazil.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 1;19(4):403-7. Unique Identifier : AIDSLINE MED/99049496; Santoro-Lopes G; Harrison LH; Moulton LH; Lima LA; de Pinho AM; Hofer C; Schechter M; Department of Preventive Medicine, Hospital Universitario; Clementino Fraga Filho, Federal University of Rio de Janeiro,; Brazil.; The relation between gender and survival after a diagnosis of AIDS was studied in a cohort of patients with HIV infection in Rio de Janeiro, Brazil . During the study period, 124 of 617 patients (20%) developed AIDS. Of this group, 91 patients were men and 33 were women. There were
Hepatitis G virus RNA is common in AIDS patients' plasma but is not associated with abnormal liver function tests or other clinical syndromes.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 1;19(4):408-12. Unique Identifier : AIDSLINE MED/99049497; Woolley I; Valdez H; Walker C; Landay A; Zdunek D; Hess G; Lederman MM; Division of Infectious Diseases, University Hospitals of; Cleveland, Center for AIDS Research, Case Western Reserve; University, Ohio 44106-5083, USA. ian.woolley@UHHS.com; Hepatitis G virus (HGV) is a new virus found in 1% to 4% of blood from all donors but is more prevalent in some immunocompromised groups, with unclear clinical significance. Frozen plasma samples from 192 AIDS patients were tested for HGV RNA; 44 (23%) were positive. Positive patients did not differ from negative pati
Sociodemographic and behavioral characteristics of African-American women with HIV and AIDS in Los Angeles County, 1990-1997.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 1;19(4):413-20. Unique Identifier : AIDSLINE MED/99049498; Wohl AR; Lu S; Odem S; Sorvillo F; Pegues CF; Kerndt PR; HIV Epidemiology Program, Los Angeles County Department of Health; Services, California 90005, USA.; African-American women have the highest AIDS rate of any racial/ethnic group of women in both Los Angeles County (LAC), California and in the United States . Limited population-based epidemiologic studies of African-American women with HIV and AIDS describe this group and examine the fa
Suppression of skin reactivity to purified protein derivative by hepatitis C virus among HTLV-I carriers in Japan.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 1;19(4):421-5. Unique Identifier : AIDSLINE MED/99049499; Hisada M; Shima T; Okayama A; Mueller N; Tsubouchi H; Stuver S; Department of Epidemiology, Harvard School of Public Health,; Boston, Massachusetts 02115, USA.; In a population endemic for HTLV-I and hepatitis C virus (HCV), HTLV-I infection has been associated with a suppressed cell-mediated immunity measured by anergy to purified protein derivative (PPD). However, the effect of HCV and the impact of coinfection with HTLV-I and HCV have not been previously evaluated. To appr
HTLV-I in Northeast Brazil: differences for male and female injecting drug users.: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 1;19(4):426-9. Unique Identifier : AIDSLINE MED/99049500; Dourado I; Andrade T; Galvao-Castro B; Instituto de Saude Coletiva, Salvador, Bahia, Brazil.; maines@ufba.br; BACKGROUND: To investigate the seroprevalence of HTLV-I infection among male and female injecting drug users (IDUs). METHODS: A cross-sectional study conducted in Salvador, Brazil , from 1994 to 1996 (Projeto Brasil-Salvador). The study population of 216 asymptomatic IDUs was select
CXCR4 polymorphisms and HIV-1 pathogenesis [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 1;19(4):430. Unique Identifier : AIDSLINE MED/99049501; Martin MP; Carrington M; Dean M; O'Brien SJ; Sheppard HW; Wegner SA; Michael NL
HIV-1, HTLV-I, and HTLV-II in a semiurban population in East Gabon [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 1;19(4):430-2. Unique Identifier : AIDSLINE MED/99049502; Bertherat E; Makuwa M; Renaut A; Nabias R; Georges-Courbot MC
The influence of antigenic variation on cytotoxic T lymphocyte responses in HIV-1 infection.: J Mol Med. 1998 Sep;76(10):699-708. Unique Identifier : AIDSLINE MED/98438238; Price DA; Meier UC; Klenerman P; Purbhoo MA; Phillips RE; Sewell AK; Nuffield Department of Clinical Medicine, University of Oxford,; John Radcliffe Hospital, UK.; The propensity of HIV-1 for genetic variation, a consequence of error-prone reverse transcription combined with high rates of replication, is thought to contribute to the establishment of persistent infection in the host despite the presence of a vigorous antiviral immune response. Protective immunity to viruses is me
Long-read direct infrared sequencing of crude PCR products for prediction of resistance to HIV-1 reverse transcriptase and protease inhibitors.: Mol Biotechnol. 1998 Aug;10(1):1-8. Unique Identifier : AIDSLINE MED/98452454; Zazzi M; Riccio ML; Venturi G; Catucci M; Romano L; De Milito A; Valensin PE; Dipartimento di Biologia Molecolare, Universita di Siena, Italy.; zazzi@sivax.unisi.it; Patients infected with human immunodeficiency virus type 1 (HIV-1) are being treated with a number of different combinations of antiretroviral compounds that target the essential viral enzymes reverse transcriptase and protease. Different sets of HIV-1 mutations that confer drug resistance have been well defined; they
HIV-1 A-rich RNA loop mimics the tRNA anticodon structure.: Nat Struct Biol. 1998 Dec;5(12):1033-6. Unique Identifier : AIDSLINE PDB/1BVJ; Puglisi EV; Puglisi JD; Department of Structural Biology, Stanford University School of; Medicine, California 94305-5400, USA.; Interaction of HIV-1 genomic RNA and human tRNA(Lys)3 initiates viral reverse transcription. An adenosine-rich (A-rich) loop in HIV RNA mediates complex formation between tRNA and viral RNA. We have determined the structure of an A-rich loop oligonucleotide using nuclear magnetic resonance spectroscopy. The loop struc
Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr.: Nat Struct Biol. 1998 Dec;5(12):1042-7. Unique Identifier : AIDSLINE PDB/1UBA; Dieckmann T; Withers-Ward ES; Jarosinski MA; Liu CF; Chen IS; Feigon J; Department of Chemistry and Biochemistry and the Molecular; Biology Institute, University of California at Los Angeles,; 90095, USA.; The HIV-1 protein Vpr is critical for a number of viral functions including a unique ability to arrest T-cells at a G2/M checkpoint and induce subsequent apoptosis. It has been shown to interact specifically with the second UBA (ubiquitin associated) domain found in the DNA repair protein HHR23A, a highly evolutionari
Two antiretroviral drugs likely to be confused [letter]: Am J Health Syst Pharm. 1998 Aug 15;55(16):1728-9. Unique Identifier : AIDSLINE MED/98413348; Johnson JT; Dunn EB; Wolfe JJ
Report updates recommendations for health workers exposed to HIV [news]: Am J Health Syst Pharm. 1998 Sep 1;55(17):1755. Unique Identifier : AIDSLINE MED/99073548
Compliance issues in the treatment of HIV infection.: Am J Health Syst Pharm. 1998 Sep 1;55(17):1817-24. Unique Identifier : AIDSLINE MED/98448471; Tseng AL; Immunodeficiency Clinic, Toronto Hospital, Ontario, Canada.; atseng@torhosp.toronto.on.ca
Levels of cytokines and immune activation markers in plasma in human immunodeficiency virus infection: quality control procedures.: Clin Diagn Lab Immunol. 1998 Nov;5(6):755-61. Unique Identifier : AIDSLINE MED/99019775; Aziz N; Nishanian P; Fahey JL; Department of Microbiology and Immunology, Center for; Interdisciplinary Research in Immunology and Disease, Jonsson; Comprehensive Cancer Center and UCLA AIDS Institute, UCLA School; of Medicine, Los Angeles, California 90095-1747, naziz@ucla.edu; Procedures for quality control (QC) in a laboratory that concentrates on cytokine and soluble marker measurements in biological fluids are outlined. Intra-assay, interassay, and interlaboratory experiences are presented. Plasma and serum beta2-microglobulin (beta2M) and neopterin test data are presented in greatest de
Effect of ethanol on monocytic function in human immunodeficiency virus type 1 infection.: Clin Diagn Lab Immunol. 1998 Nov;5(6):790-8. Unique Identifier : AIDSLINE MED/99019781; Chen H; George I; Sperber K; Division of Clinical Immunology, Mount Sinai Medical Center, New; York, New York 10029, USA.; We have developed a novel system to study monocytic function after human immunodeficiency virus type 1 (HIV-1) infection by infecting a series of human macrophage hybridoma cell lines with HIV-1. Since ethanol has detrimental effects on immune function, we investigated the effect of ethanol and its metabolites acetald
Effect of shipment, storage, anticoagulant, and cell separation on lymphocyte proliferation assays for human immunodeficiency virus-infected patients.: Clin Diagn Lab Immunol. 1998 Nov;5(6):804-7. Unique Identifier : AIDSLINE MED/99019783; Weinberg A; Betensky RA; Zhang L; Ray G; University of Colorado School of Medicine, Denver, Colorado, USA.; adriana.weinberg@uchsc.edu; Lymphocyte proliferation assays (LPA), which can provide important information regarding the immune reconstitution of human immunodeficiency virus (HIV)-infected patients on highly active antiretroviral therapy, frequently involve shipment of specimens to central laboratories. In this study, we examine the effect of s
Human T-cell lymphotropic virus type 1 tax among American blood donors.: Clin Diagn Lab Immunol. 1998 Nov;5(6):831-5. Unique Identifier : AIDSLINE MED/99019789; Zucker-Franklin D; Pancake BA; Department of Medicine, New York University Medical Center, New; York, New York 10016, USA.; In the United States , all blood used for transfusion is tested for the presence of antibodies to the structural components of the human T-cell lymphotropic viruses types 1 and 2 (HTLV-1 and 2). Based on such serologic tests, the prevalence of HTLV-1 infection is estimated to range from
Transcriptional activation of NF-kappa B activity by Epstein-Barr virus (EBV) LMP1 as a selective therapeutic strategy for EBV-associated diseases.: Unique Identifier : AIDSLINE MED/99031204; Wu CJ; Leu CY; Liu ST; Chow KP; Meng CL; Chang YS; Epstein-Barr virus (EBV) has been known to be associated with many malignant tumors, including nasopharyngeal carcinoma (NPC). Previous studies have indicated that an EBV-encoded oncoprotein, latent membrane protein 1 (LMP1), is expressed in many NPC tissues. LMP1 has been shown to stimulate HIV LTR through the two NF
Inhibition of Tat-mediated transactivation and HIV replication with Tat mutant and repressor domain fusion proteins.: Gene Ther. 1998 Jul;5(7):946-54. Unique Identifier : AIDSLINE MED/99031209; Fraisier C; Abraham DA; van Oijen M; Cunliffe V; Irvine A; Craig R; Dzierzak EA; National Institute for Medical Research, Division of Eukaryotic; Molecular Genetics, London, UK.; Strategies to inhibit the spread of HIV infection consist of a number of specific molecular approaches. Since viral production is dependent upon Tat-mediated transactivation of the HIV promoter through the Tat activating region (TAR), tat antisense RNA, anti-tat ribozymes, TAR decoys and dominant negative Tat mutant p
Genetic co-inactivation of macrophage- and T-tropic HIV-1 chemokine coreceptors CCR-5 and CXCR-4 by intrakines.: Gene Ther. 1998 Jul;5(7):984-94. Unique Identifier : AIDSLINE MED/99031213; Bai X; Chen JD; Yang AG; Torti F; Chen SY; Department of Cancer Biology, Comprehensive Cancer Center, Wake; Forest University School of Medicine, Winston-Salem, NC 27157,; USA.; CC-chemokine receptor (CCR)-5 is the principal coreceptor for the entry of macrophage (M)-tropic HIV-1 viruses into a cell, while CXC-chemokine receptor (CXCR)-4 is the principal coreceptor for T cell line (T)-tropic HIV-1. In this study, we utilized a novel intracellular chemokine (intrakine) strategy to co-inactivat
[The mechanism of donor specific unresponsiveness in renal transplant recipients]: Nihon Rinsho Meneki Gakkai Kaishi. 1998 Jun;21(3):118-28. Unique Identifier : AIDSLINE MED/98426622; Okimoto T; Yahata H; Fukuda Y; Dohi K; Second Department of Surgery, School of Medicine, University of; Hiroshima.; A study was conducted to clarify the mechanism of donor specific immunological unresponsiveness in renal transplant recipients with a well functioning kidney, since this might provide a clue to the nature of donor specific immunosuppression. Peripheral blood lymphocytes (PBL) were obtained from three renal transplant
Theophylline and airway inflammation.: Clin Exp Allergy. 1998 Aug;28 Suppl 3:35-41. Unique Identifier : AIDSLINE MED/98427615; Rabe KF; Dent G; Krankenhaus Grosshansdorf, Zentrum fur Pneumologie und; Thoraxchirurgie, LVA Hamburg, Germany.; The view of theophylline as a second-line bronchodilator in asthma therapy has begun to be reconsidered in recent years as the details of its additional actions on airway inflammation have emerged. Increasing understanding of the mechanisms of action of theophylline has led to an appreciation of the ways in which this
Hypersensitivity reactions to drugs in HIV-infected patients. Allergic evaluation and desensitization.: Clin Exp Allergy. 1998 Sep;28 Suppl 4:57-60. Unique Identifier : AIDSLINE MED/98432178; Moreno-Ancillo A; Lopez-Serrano MC; La Paz General University Hospital, Madrid, Spain.
The role of helper T cell subsets in autoimmune diseases.: Cytokine Growth Factor Rev. 1998 Jun;9(2):139-51. Unique Identifier : AIDSLINE MED/98425703; Lafaille JJ; Skirball Institute for Biomedical Research and Dept. of; Pathology, New York University School of Medicine, NY, USA.; lafaille@saturn.med.nyu.edu; CD4 helper T cells can be divided into Th1 and Th2 subsets based upon the cytokines they produce. Th1 and Th2 cells have been found to be mutually antagonistic, leading to either Th1- or Th2-dominated responses upon immunization. In recent years, several authors have suggested that in chronic inflammatory autoimmune d
HIV risk behaviors associated with the injection process: multiperson use of drug injection equipment and paraphernalia in injection drug user networks.: Unique Identifier : AIDSLINE MED/98453082; Needle RH; Coyle S; Cesari H; Trotter R; Clatts M; Koester S; Price L; McLellan E; Finlinson A; Bluthenthal RN; Pierce T; Johnson J; Jones TS; Williams M; This study examines drug acquisition and multiperson use of paraphernalia, drugs, and needles/syringes. Ethnographers observed 54 injection episodes in which IDUs were linked by HIV risk behaviors, and developed a typology of higher-risk, lower-risk, and nonsharing-risk networks. Multiperson use of
A 12-year study (1975-1986) of mortality in methadone-maintenance patients: selected demographic characteristics and drug-use patterns of AIDS and non-AIDS-related deaths.: Subst Use Misuse. 1998 Oct;33(12):2521-34. Unique Identifier : AIDSLINE MED/98453089; Petry NM; Bickel WK; Badger GJ; Substance Abuse Treatment Center and Department of Psychology,; University of Vermont, Burlington 05401, USA.; This paper describes changes in demographic characteristics and drug use patterns of persons who died while enrolled in a New York City methadone-maintenance program during the years preceding and subsequent to the AIDS epidemic. Persons dying from AIDS were more likely to be younger, Hispanic, and male than those dyi
China faces increased spread of HIV [news]: Nat Med. 1998 Nov;4(11):1216. Unique Identifier : AIDSLINE MED/99025381; Watanabe M
The importance of doing HIV research in developing countries.: Nat Med. 1998 Nov;4(11):1228-9. Unique Identifier : AIDSLINE MED/99025389; Morris L; Martin DJ; Quinn TC; Chaisson RE; AIDS Virus Research Unit, National Institute for Virology,; Johannesburg, South Africa.
Nailing down another HIV target [news; comment]: Nat Med. 1998 Nov;4(11):1232-3. Unique Identifier : AIDSLINE MED/99025391; Richman DD
Regulation of host immune responses by modification of Salmonella virulence genes.: Nat Med. 1998 Nov;4(11):1247-52. Unique Identifier : AIDSLINE MED/99025401; VanCott JL; Chatfield SN; Roberts M; Hone DM; Hohmann EL; Pascual DW; Yamamoto M; Kiyono H; McGhee JR; Children's Hospital Medical Center, Division of Infectious; Disease, Cincinnati, Ohio 45229, USA.; Modifying bacterial virulence genes to probe the nature of host immunity is mostly unexplored. Here we investigate whether host immune responses can be regulated by modification of bacterial virulence genes. In mice, attenuated Salmonella mutant strains with clinical relevance elicited differential host immune respons
Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry [see comments]: Nat Med. 1998 Nov;4(11):1302-7. Unique Identifier : AIDSLINE MED/99025409; Kilby JM; Hopkins S; Venetta TM; DiMassimo B; Cloud GA; Lee JY; Alldredge L; Hunter E; Lambert D; Bolognesi D; Matthews T; Johnson MR; Nowak MA; Shaw GM; Saag MS; Department of Medicine, University of Alabama at Birmingham,; 35294-2050, USA.; T-20, a synthetic peptide corresponding to a region of the transmembrane subunit of the HIV-1 envelope protein, blocks cell fusion and viral entry at concentrations of less than 2 ng/ml in vitro. We administered intravenous T-20 (monotherapy) for 14 days to sixteen HIV-infected adults in four dose groups (3, 10, 30 an
The Molecular Medicine Revolution [editorial]: Nat Med. 1998 Dec;4(12):1339-40. Unique Identifier : AIDSLINE MED/99060984
ApoE-viral interactions [letter]: Nat Med. 1998 Dec;4(12):1344. Unique Identifier : AIDSLINE MED/99060988; Itzhaki RF; Wozniak M; Dobson C; Lin WR
When accessories turn out to be essential [news; comment]: Nat Med. 1998 Dec;4(12):1368-9. Unique Identifier : AIDSLINE MED/99061005; Trono D
Evidence for a newly discovered cellular anti-HIV-1 phenotype [see comments]: Nat Med. 1998 Dec;4(12):1397-400. Unique Identifier : AIDSLINE MED/99061011; Simon JH; Gaddis NC; Fouchier RA; Malim MH; Department of Microbiology, University of Pennsylvania School of; Medicine, Philadelphia 19104-6148, USA.; Animal cells have developed many ways to suppress viral replication, and viruses have evolved diverse strategies to resist these. Here we provide evidence that the virion infectivity factor protein of human immunodeficiency virus type 1 (HIV-1) functions to counteract a newly discovered activity in human cells that ot
Penicillium marneffei fungemia in an AIDS patient: the first case report in Taiwan [letter]: Chang Keng I Hsueh Tsa Chih. 1998 Sep;21(3):362. Unique Identifier : AIDSLINE MED/99065871; Luh KT
Alcohol use, drug use, and sexual activity among pharmacy students at three institutions.: J Am Pharm Assoc (Wash). 1998 Sep-Oct;38(5):609-13. Unique Identifier : AIDSLINE MED/98456015; Noormohamed SE; Ferguson KJ; Baghaie A; Cohen LG; College of Pharmacy, University of Iowa, Iowa City 52242, USA.; saleem-noormohamed@uiowa.edu; OBJECTIVE: To determine alcohol and drug use and sexual activity among pharmacy students at three colleges of pharmacy. DESIGN AND SETTING: A survey to obtain self-reported information on alcohol and drug use, and sexual activity was administered to professional pharmacy students at the University of Iowa (UI), Massac
Age-related changes in major lymphocyte subsets in cynomolgus monkeys.: Exp Anim. 1998 Jul;47(3):159-66. Unique Identifier : AIDSLINE MED/99033279; Nam KH; Akari H; Terao K; Itagaki S; Yoshikawa Y; Tsukuba Primate Center, National Institute of Infectious; Diseases, Ibaraki, Japan.; Age-related changes in major lymphocyte subsets were analyzed in 195 cynomolgus monkeys (Macaca fascicularis) aged from one month to 31 years. The percentages of CD20+ B cells in peripheral blood lymphocytes (PBL) decreased with age to five years of age, but after that, no significant change was observed. The percenta
Neuro-ophthalmic findings in progressive multifocal leukoencephalopathy.: Can J Ophthalmol. 1998 Aug;33(5):270-5. Unique Identifier : AIDSLINE MED/98413390; Wein F; Francis GS; Gans MS; Connolly WE; Burnier MN Jr; Department of Ophthalmology, McGill University Hospital Centre,; Montreal, Que.; BACKGROUND: Progressive multifocal leukoencephalopathy (PML) is a demyelinating disorder of the central nervous system found in immunodeficient patients, most frequently now in those infected with HIV. It may represent the initial manifestation of HIV infection. Since the central visual pathways may be affected, a var
Prolactin, growth hormone and the immune system in humans.: Cell Mol Life Sci. 1998 Oct;54(10):1102-8. Unique Identifier : AIDSLINE MED/99035349; Velkeniers B; Dogusan Z; Naessens F; Hooghe R; Hooghe-Peters EL; Department of Pharmacology, Medical School, Free University of; Brussels (VUB), Belgium.; Prolactin (PRL) and growth hormone (GH) qualify as lymphoid growth and differentiation factors. Yet, long-standing hyper- or hyposecretion of PRL or GH does not induce any significant alteration of the immune system. Subclinical changes in laboratory parameters (such as chemotaxis or phagocytosis by granulocytes or ma
Ribozyme gene therapy for hepatitis C virus infection.: Clin Diagn Virol. 1998 Jul 15;10(2-3):163-71. Unique Identifier : AIDSLINE MED/98412673; Welch PJ; Yei S; Barber JR; Immusol Inc., San Diego, CA 92121, USA.; BACKGROUND: The development of antiviral drugs for hepatitis C virus (HCV) infection represents a substantial challenge. Similar to human immunodeficiency virus (HIV), HCV is highly prone to mutation. It is, therefore, expected that potential HCV therapeutics currently under development, such as
Suppression of HHV-8 viremia by foscarnet in an HIV-infected patient with Kaposi's sarcoma and HHV-8 associated hemophagocytic syndrome.: Eur J Med Res. 1998 Oct 14;3(10):461-4. Unique Identifier : AIDSLINE MED/98428700; Low P; Neipel F; Rascu A; Steininger H; Manger B; Fleckenstein B; Kalden JR; Harrer T; Department of Medicine III with Institute of Clinical Immunology,; University of Erlangen-Nuremberg, Krankenhausstrasse 12, D-91054; Erlangen, Germany.; Human herpes virus 8 (HHV-8) seems to be involved in the pathogenesis of Kaposi s sarcoma. In vitro, antiviral drugs with activity against herpes viruses also can suppress HHV-8, however, little is known about the antiviral activity against HHV-8 in vivo. In this report we describe the effects of foscarnet on HHV-8 vi
HIV postexposure prophylaxis. German-Austrian recommendations. Deutsche AIDS-Gesellschaft (DAIG) and Osterreichische AIDS- Gesellschaft (OAG).: Eur J Med Res. 1998 Oct 14;3(10):485-500. Unique Identifier : AIDSLINE MED/98428705; Brodt H; Zentrum der Inneren Medizin, Medizinische Klinik; III/Infektiologie, Theodor-Stern-Kai 7, D-60590 Frankfurt,; Germany. Brodt@DAIG.NET.
Psychotropic adjuvant analgesics for pain in cancer and AIDS.: Psychooncology. 1998 Jul-Aug;7(4):333-45. Unique Identifier : AIDSLINE MED/98413506; Breitbart W; Department of Psychiatry and Behavioral Sciences, Memorial; Sloan-Kettering Cancer Center, New York, NY, USA.; breitbaw@mskcc.org; The WHO Analgesic Ladder is a well validated approach for the selection of appropriate analgesic therapy for cancer pain as well as pain in AIDS. The mainstay of analgesic intervention for cancer and AIDS pain of moderate to severe intensity continues to be the appropriate use of opioid analgesics. There is, however
[Surveillance and control of some emerging zoonoses]: Chung Hua Liu Hsing Ping Hsueh Tsa Chih. 1997 Feb;18(1):47-9. Unique Identifier : AIDSLINE MED/99029026; Yu ES
[Genetic subtyping of HIV-1 strains by heteroduplex mobility assay]: Chung Hua Liu Hsing Ping Hsueh Tsa Chih. 1997 Aug;18(4):201-4. Unique Identifier : AIDSLINE MED/99029060; Yu H; Su L; Shao JJ; Institute of Virology, CAPM, Beijing.; DNA fragments of HIV-1 env gene were amplified by nested PCR from uncultured peripheral blood mononuclear cells (PBMCs) obtained from 24 HIV-1 infected individuals. The PCR products were separated by melting and annealing with denatured PCR product prepared from reference plasimd of representative subtypes. Heterodupl
[Subtype and sequence analysis of the C2-V3 region of gp120 genes among HIV-1 strains in Hubei province]: Chung Hua Liu Hsing Ping Hsueh Tsa Chih. 1997 Aug;18(4):217-9. Unique Identifier : AIDSLINE MED/99029065; Li YW; Shao YM; Luo XG; Hubei Sanitation and Anti-epidemic Station, Wuhan.; Twenty DNA fragments of HIV-1 env gene were amplified by PCR from uncultured peripheral blood mononuclear cells (PBMCs) obtained from HIV-1 sero-positive people from Hubei province in the end of 1996. The C2-V3 region (about 450 bp) was sequenced. Sequence analyses showed that all of them were HIV-1 subtypes, B strain
Impact of HIV counselling and testing on HIV seroconversion and reported STD incidence among male factory workers in Harare, Zimbabwe.: Cent Afr J Med. 1998 Apr;44(4):98-102. Unique Identifier : AIDSLINE MED/99028097; Machekano R; McFarland W; Mbizvo MT; Bassett MT; Katzenstein D; Latif AS; Zimbabwe Aids Prevention Project, University of Zimbabwe Medical; School, Harare, Zimbabwe. zapp@id.co.zw; OBJECTIVES: To assess the impact of HIV counselling and testing on HIV seroconversion and incidence of reported sexually transmitted diseases (STDs) among male factory workers in Harare, Zimbabwe . DESIGN: Prospective, observational study among men recruited to participate in a fu
Seroprevalence study of HTLV-1 and HIV infection in blood donors and patients with lymphoid malignancies in Lagos, Nigeria.: Cent Afr J Med. 1998 May;44(5):130-4. Unique Identifier : AIDSLINE MED/99028106; Analo HI; Akanmu AS; Akinsete I; Njoku OS; Okany CC; Department of Haematology and Blood Transfusion, College of; Medicine, University of Lagos, Nigeria.; OBJECTIVE: To document the seroprevalence of HTLV-1 and HIV in blood donors and in patients with lymphoma and leukaemia in Lagos metropolis. DESIGN: Cross sectional. SETTING: The Lagos University Teaching Hospital (LUTH) and General Hospital, Lagos (GH). SUBJECTS: 406 apparently healthy voluntary blood donors from the
Proliferative response of CD8+ gamma delta+ T cells to Streptococcus sanguis in patients with Behcet's disease.: Ocul Immunol Inflamm. 1998 Sep;6(3):139-44. Unique Identifier : AIDSLINE MED/99001782; Nishida T; Hirayama K; Nakamura S; Ohno S; Department of Ophthalmology, Yokohama City University School of; Medicine, Japan.; To analyze the pathogenesis of Behcet s disease (BD), we investigated the immune response of peripheral blood T cell subsets from patients with BD to Streptococcus sanguis (S. sanguis) strain KTH-I, a bacteria suggested to be associated with the etiology of BD. Cultured peripheral blood mononuclear cells (PBMC) of pat
Idiosyncratic alterations of TCR size distributions affecting both CD4 and CD8 T cell subsets in aging mice.: Cell Immunol. 1998 Oct 10;189(1):10-8. Unique Identifier : AIDSLINE MED/98432916; Mosley RL; Koker MM; Miller RA; Department of Pathology, University of Michigan Medical Center,; Omaha, NE 68198-5660, USA.; We have used a spectratyping method, which displays the size distribution for the complementarity-determining region 3 (CDR3) for T cells utilizing a specific TCR-Vbeta gene, to examine the effects of aging on the TCR repertoire of (BALB/c x C57BL/6)F1 hybrid mice. Although the size distributions from T cells of 8-mon
The impact of variation in the number of CD8(+) T-cell precursors on the outcome of virus infection.: Cell Immunol. 1998 Oct 10;189(1):67-73. Unique Identifier : AIDSLINE MED/98432923; Ehl S; Klenerman P; Zinkernagel RM; Bocharov G; Department of Pathology, University of Zurich, Zurich, CH-8091,; Switzerland. STEPHANEHL@AOL.COM; We investigated the role of varying the initial number of naive antiviral CTL precursors on the dynamics of LCMV-DOCILE infection. C57BL/6 mice, exhibiting LCMV-specific CTLp frequencies of about 50, are protected against virus persistence over a range of infectious doses up to 10(4) pfu. With 10-fold higher doses, a
Host susceptibility factors to cutaneous leishmaniasis.: Front Biosci. 1998 Nov 15;3:D1171-80. Unique Identifier : AIDSLINE MED/99038266; Jones DE; Elloso MM; Scott P; Department of Pathobiology, School of Veterinary Medicine,; University of Pennsylvania, Philadelphia, Pennsylvania 19104,; USA. jonesdou@mail.med. upenn.edu; The host-pathogen relationship is the focus of many different studies which use a variety of disease models and different pathogens. Immunological studies in the mouse using the intracellular parasite Leishmania have helped define several aspects of host-pathogen interactions. Resistance to Leishmania is dependent on
Talking about HIV [letter]: CMAJ. 1998 Oct 20;159(8):920-1. Unique Identifier : AIDSLINE MED/99051777; Keystone D
Routine prenatal screening for HIV in a low-prevalence setting.: CMAJ. 1998 Oct 20;159(8):942-7. Unique Identifier : AIDSLINE MED/99051784; Patrick DM; Money DM; Forbes J; Dobson SR; Rekart ML; Cook DA; Middleton PJ; Burdge DR; British Columbia Centre for Disease Control Society, Vancouver.; david.patrick@bccdc.hnet.bc.ca; BACKGROUND: The objectives of this study were to assess the effect of British Columbia s June 1994 guidelines for prenatal HIV screening on the rate of maternal-fetal HIV transmission and to estimate the cost-effectiveness of such screening. METHODS: The authors conducted a retrospective review of pregnancy and delive
Sexually transmitted diseases in sexually abused children: medical and legal implications.: Sex Transm Infect. 1998 Jun;74(3):167-74. Unique Identifier : AIDSLINE MED/99066412; Hammerschlag MR; Department of Pediatrics, SUNY Health Science Center at Brooklyn; 11203-2098, USA.; Sexually transmitted diseases (STDs) may be transmitted during sexual assault. In children, the isolation of a sexually transmitted organism may be the first indication that abuse has occurred. Although the presence of a sexually transmissible agent from a child beyond the neonatal period is suggestive of sexual abuse
Presentation, pathology, and outcome of HIV associated renal disease in a specialist centre for HIV/AIDS.: Unique Identifier : AIDSLINE MED/99066414; Williams DI; Williams DJ; Williams IG; Unwin RJ; Griffiths MH; Miller RF; Department of Sexually Transmitted Diseases, UCL Medical School,; London.; OBJECTIVES: To describe the presentation, pathology, and outcome of biopsy proved renal disease in HIV infected patients at a central London HIV unit from 1992 to 1996. METHODS: Retrospective review of a computerised database and case notes to identify patients with renal disease confirmed by antemortem percutaneous r
HIV infection among homosexual/bisexual males attending genitourinary clinics in Scotland.: Sex Transm Infect. 1998 Jun;74(3):185-8. Unique Identifier : AIDSLINE MED/99066415; Goldberg D; Scott G; Weir M; Cameron S; Peutherer J; McMillan A; Leadbetter G; Scoular A; Codere G; Allardice G; Scottish Centre for Infection and Environmental Health, Ruchill; Hospital, Glasgow.; BACKGROUND: Since 1991, unlinked anonymous HIV testing of homosexual/bisexual males attending genitourinary clinics in Edinburgh and Glasgow has been conducted and resulting prevalence data have been published annually. More detailed information which provides an understanding of what proportion of HIV infected men at
The supermarket for women's reproductive health: the burden of genital infections in a family planning clinic in Nairobi, Kenya.: Sex Transm Infect. 1998 Jun;74(3):202-4. Unique Identifier : AIDSLINE MED/99066418; Temmerman M; Kidula N; Tyndall M; Rukaria-Kaumbutho R; Muchiri L; Ndinya-Achola JO; Department Obstetrics and Gynaecology, University of Ghent,; Belgium.; OBJECTIVES: To study the burden of disease of reproductive tract infections (RTIs) and cervical dysplasia in women attending a family planning clinic in Nairobi, Kenya , and to assess the acceptability of integrating reproductive healthcare services into existing family planning faci
How to assess an article on economic evaluation.: Sex Transm Infect. 1998 Jun;74(3):223-7. Unique Identifier : AIDSLINE MED/99066425; Sculpher M; Mercey D; Centre for Health Economics, University of York, Heslington.
AIDS associated eosinophilic folliculitis which responded to both high dose co-trimoxazole and low dose isotretinoin [letter]: Sex Transm Infect. 1998 Jun;74(3):229-30. Unique Identifier : AIDSLINE MED/99066429; Downs AM; Lear JT; Oxley JD; Kennedy CT
Peripheral blood B and T lymphocyte subsets [letter]: Sex Transm Infect. 1998 Jun;74(3):231-2. Unique Identifier : AIDSLINE MED/99066434; Aldeen T; Lau RK
Simultaneous determination of ritonavir and saquinavir, two human immunodeficiency virus protease inhibitors, in human serum by high-performance liquid chromatography.: J Chromatogr B Biomed Sci Appl. 1998 Sep 4;714(2):384-9. Unique Identifier : AIDSLINE MED/98438271; Frappier S; Breilh D; Diarte E; Ba B; Ducint D; Pellegrin JL; Saux MC; Clinical Pharmacokinetic Department, Victor Segalen University; Bordeaux France and Pharmacy Haut-leveque Hospital, Pessac.; The aim of this study was to describe an high-performance liquid chromatographic assay for the simultaneous determination of two HIV protease inhibitors , saquinavir and ritonavir , in human serum. Th
Fulminant Epstein-Barr viral hepatitis: orthotopic liver transplantation and review of the literature.: Liver Transpl Surg. 1998 Nov;4(6):469-76. Unique Identifier : AIDSLINE MED/99009191; Feranchak AP; Tyson RW; Narkewicz MR; Karrer FM; Sokol RJ; Pediatric Liver Center and Liver Transplantation Program, The; Children's Hospital, Denver, CO, USA.; Acute hepatic failure caused by primary Epstein-Barr virus (EBV) infection has been reported in the literature in 16 cases, with an overall mortality of 87%. We report a case of fulminant hepatic failure in an immunocompetent young girl caused by primary EBV infection that was treated by orthotopic liver transplantati
DNA binding properties of the nucleocapsid protein from human T-cell leukemia virus type-I.: Int J Oncol. 1998 Oct;13(4):749-55. Unique Identifier : AIDSLINE MED/98408014; Chechelnitsky G; Priel E; Department of Microbiology and Immunology, Cancer Research; Center, Faculty of Health Sciences, Ben-Gurion University of the; Negev, Beer-Sheva, Israel.; Biochemical and genetic data on retroviral nucleocapsid (NC) proteins have shown that this viral protein exhibits nucleic acid annealing and strand transfer activities and is required for the formation of infectious viral particles. However, the DNA binding properties of the NC protein of the human T-cell leukemia vir
Reduction of telomeric signals in murine melanoma and human breast cancer cell lines treated with 3'-azido-2'-3'-dideoxythymidine.: Int J Oncol. 1998 Nov;13(5):923-5. Unique Identifier : AIDSLINE MED/98447828; Multani AS; Furlong C; Pathak S; Department of Cancer Biology, The University of Texas M.D.; Anderson Cancer Center, Houston, TX 77030, USA.; The purpose of this study was to determine, using fluorescence in situ hybridization (FISH), whether treatment of cancer cells with 3 -azido-2 -3 -dideoxythymidine ( AZT ) has any effect on telomere length as determined by the telomeric signal intensity
Tuberculosis 2000: problems and solutions.: Int J Tuberc Lung Dis. 1998 Sep;2(9):696-703. Unique Identifier : AIDSLINE MED/98427353; Pilheu JA; University of Buenos Aires School of Medicine, Argentina.; The incidence of tuberculosis is expected to increase, from 8.8 million cases in 1995, to 10.2 million cases by the year 2000 and 11.9 million by 2005. Three million deaths due to tuberculosis occurred in 1995, and 3.5 million can be expected in the year 2000. The most important causes of the world-wide increase in tu
Factors determining the outcome of treatment of adult smear-positive tuberculosis cases in The Gambia.: Int J Tuberc Lung Dis. 1998 Sep;2(9):712-8. Unique Identifier : AIDSLINE MED/98427355; Lienhardt C; Manneh K; Bouchier V; Lahai G; Milligan PJ; McAdam KP; Medical Research Council Laboratories, The Gambia.; clienhardt@gam.healthnet.org; SETTING: Health centres in The Gambia , West Africa. OBJECTIVES: To identify factors determining the outcome of treatment of adult tuberculosis cases in a Tuberculosis Control Programme using directly observed treatment. DESIGN: Information on the outcome of treatment was collected
Serum vitamin A levels during tuberculosis and human immunodeficiency virus infection.: Int J Tuberc Lung Dis. 1998 Sep;2(9):771-3. Unique Identifier : AIDSLINE MED/98427364; Rwangabwoba JM; Fischman H; Semba RD; Centre Universitaire de Sante Publique, Butare, Rwanda.; Vitamin A deficiency during tuberculosis and human immunodeficiency virus (HIV) infection has not been characterized. A cross-sectional study was conducted among HIV-infected adults with tuberculosis in Butare, Rwanda , in which 29% of the subjects had serum vitamin A levels consist
Multidrug-resistant tuberculous meningitis in a health care worker [letter]: Int J Tuberc Lung Dis. 1998 Sep;2(9):774. Unique Identifier : AIDSLINE MED/98427365; Silber E; Sonnenberg P; Saffer D; Koornhof HJ
TB and HIV in Bolivia [letter]: Int J Tuberc Lung Dis. 1998 Sep;2(9):775-6. Unique Identifier : AIDSLINE MED/98427367; Olle-Goig JE; Ferrel M
Tuberculosis control in prisons.: Int J Tuberc Lung Dis. 1998 Sep;2(9 Suppl 1):S57-63. Unique Identifier : AIDSLINE MED/98427398; Kendig N; Federal Bureau of Prisons, Washington, DC 20534, USA. nek@bop.gov
Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease.: Chem Pharm Bull (Tokyo). 1998 Oct;46(10):1607-12. Unique Identifier : AIDSLINE MED/99028390; Min BS; Nakamura N; Miyashiro H; Bae KW; Hattori M; Research Institute for Traditional Sino-Japanese Medicines,; Toyama Medical and Pharmaceutical University, Japan.; Two new lanostane-type triterpenes, lucidumol A and ganoderic acid beta, were isolated from the spores of Ganoderma (G.) lucidum, together with a new natural one and seven that were known. The structures of the new triterpenes were determined as (24S)-24,25-dihydroxylanost-8-ene-3,7-dione and 3 beta,7 beta-dihydroxy-1
Qualitative immunoglobulin abnormalities in HIV-positive patients: long-term follow-up.: Clin Chem Lab Med. 1998 Jun;36(7):493-6. Unique Identifier : AIDSLINE MED/98417357; Pontet F; Gue X; Mazeron MC; Alain S; Sanson-Le Pors MJ; Service de Biochimie, Hopital Lariboisiere, Paris, France.; We studied the immunoglobulins of a cohort of 212 HIV-positive patients followed-up for 13 years. The qualitative study of immunoglobulins by immunoelectrophoresis and immunofixation distinguished three groups of patients: those with monoclonal immunoglobulins, those with minor abnormalities of immunoglobulins and tho
Shingles: a review of diagnosis and management.: Hosp Med. 1998 Oct;59(10):770-6. Unique Identifier : AIDSLINE MED/99067278; Morgan R; King D; Department of Medicine for the Elderly, Wirral NHS Trust; Hospital, Merseyside.; Herpes zoster or shingles results from reactivation of varicella zoster virus previously dormant in cells of the dorsal root ganglion. The incidence of shingles increases with age and immunosuppression. Guidelines for managing shingles are now available and implementation, with the emphasis on early treatment, may red
Active surveillance of sexual behaviour among homosexual men in London.: Commun Dis Public Health. 1998 Sep;1(3):197-201. Unique Identifier : AIDSLINE MED/98455955; Nardone A; Dodds JP; Mercey DE; Johnson AM; Department Sexually Transmitted Diseases, University College; London Medical School. tnardone@gum.ucl.ac.uk; The objective of this study was to establish a surveillance programme to monitor high risk sexual behaviour among homosexual and bisexual men socializing and/or using health care services in London. Between November 1996 and January 1997 a brief, self-completed questionnaire was distributed in various commercial venue
Parainfluenza virus and respiratory syncytial virus infection in infants undergoing bone marrow transplantation for severe combined immunodeficiency.: Commun Dis Public Health. 1998 Sep;1(3):202-3. Unique Identifier : AIDSLINE MED/98455956; Taylor CE; Osman HK; Turner AJ; Flood TJ; Abinun M; Crooks B; Cant AJ; Newcastle Public Health Laboratory, Newcastle General Hospital,; Newcastle upon Tyne. newctayl@newphls.demon.uk; Respiratory syncytial virus and parainfluenza virus infection carry a poor prognosis in severe combined immunodeficiency (SCID), particularly if the viral load is high. Patients with high viral load develop severe pneumonitis at engraftment which may possibly be modulated by immunotherapy, including high dose nebulise
Providing care in an infectious disease clinic. Why students volunteer.: Eur J Dent Educ. 1998 Aug;2(3):138-42. Unique Identifier : AIDSLINE MED/99073042; Lopez N; Glick M; Berthold P; WHO Collaborating Center, University of Pennsylvania School of; Dental Medicine, Philadelphia, USA.; This qualitative study explores the motivations of dental students who volunteered as care providers for patients identified as carriers of infectious diseases. The study involved 12 students, seven 4th year and five 3rd year students who worked 1-2.5 days per week in an infectious disease clinic in a dental school in
Circulating Th1 and Th2 cytokines in patients with hepatitis C virus infection.: Mediators Inflamm. 1998;7(4):295-7. Unique Identifier : AIDSLINE MED/99006827; Fan XG; Liu WE; Li CZ; Wang ZC; Luo LX; Tan DM; Hu GL; Zhang Z; Department of Infectious Diseases, Xiangya Hospital, Hunan; Medical University, Changsha, People's Republic of China.; The imbalance of T-helper (Th) lymphocyte cytokine production may play an important role in immunopathogenesis of persistent hepatitis C virus (HCV) infection. To know whether an imbalance between Th1 and Th2 cytokines is present in chronic HCV infection, serum levels of Th1 cytokines, interferon gamma (IFN-gamma) and
Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme.: Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54 ( Pt 5):1053-60. Unique Identifier : AIDSLINE PDB/2BPW; Munshi S; Chen Z; Li Y; Olsen DB; Fraley ME; Hungate RW; Kuo LC; Department of Antiviral Research, Merck Research Laboratories,; West Point, PA 19486, USA.; The ability to replace an inhibitor bound to the HIV-1 protease in single crystals with other potent inhibitors offers the possibility of investigating a series of protease inhibitors rapidly and conveniently with the use of X-ray crystallography. This approach affo
Continuous and discontinuous changes in the unit cell of HIV-1 reverse transcriptase crystals on dehydration.: Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54 ( Pt 5):938-53. Unique Identifier : AIDSLINE MED/98437623; Esnouf RM; Ren J; Garman EF; Somers DO; Ross CK; Jones EY; Stammers DK; Stuart DI; The Laboratory of Molecular Biophysics, Rex Richards Building,; South Parks Road, Oxford OX1 3QU, England.; A crystal form of HIV-1 reverse transcriptase (RT) complexed with inhibitors showed diffraction to a high-resolution limit of 3.7 A. Instability in the unit-cell dimensions of these crystals was observed during soaking experiments, but the range of this variability and consequent change in lattice order was revealed b
The adsorption of cellulose ethers in aqueous suspensions of pyrantel pamoate: effects on zeta potential and stability.: Eur J Pharm Biopharm. 1998 Mar;45(2):181-8. Unique Identifier : AIDSLINE MED/98368613; Duro R; Alvarez C; Martinez-Pacheco R; Gomez-Amoza JL; Concheiro A; Souto C; Departamento de Farmacia y Tecnologia Farmaceutica, Universidad; de Santiago de Compostela, Spain.; This work examined the physico-chemical phenomena induced in aqueous suspensions of pyrantel pamoate by two varieties of hydroxypropylmethylcellulose (HPMC) and sodium carboxymethylcellulose (NaCMC) of different molecular weights, and the effects of these phenomena on the physical stability of the suspension. The mech
A simple assay system for examination of the inhibitory potential in vivo of decoy RNAs, ribozymes and other drugs by measuring the Tat-mediated transcription of a fusion gene composed of the long terminal repeat of HIV-1 and a gene for luciferase.: Unique Identifier : AIDSLINE MED/98412955; Koseki S; Ohkawa J; Yamamoto R; Takebe Y; Taira K; National Institute of Bioscience and Human Technology, MITI,; Tsukuba Science City, Japan.; Nucleic acid-based drugs, including antisense RNA and DNA, ribozymes and decoys appear to have potential for the suppression of the expression of specific genes. To allow the examination of the potential of such agents in vivo as anti-HIV drugs in standard laboratories, where facilities for handling live virions are n
Development of liposomal anthracyclines: from basics to clinical applications.: J Controlled Release. 1998 Apr 30;53(1-3):275-9. Unique Identifier : AIDSLINE MED/98412966; Gabizon A; Goren D; Cohen R; Barenholz Y; Sharet Institute of Oncology, Hadassah Hebrew University, Medical; Center, Jerusalem, Israel.; The pharmacokinetics of liposome-encapsulated drugs are controlled by the interplay of two variables: the rate of plasma clearance of the liposome carrier, and the stability of the liposome-drug association in the blood stream. The pharmacokinetic properties of the liposomal drug, the vesicle size of the liposome carr
Coupling of the antiviral agent zidovudine to polyaspartamide and in vitro drug release studies.: J Controlled Release. 1998 Aug 14;54(3):321-31. Unique Identifier : AIDSLINE MED/98439389; Giammona G; Cavallaro G; Fontana G; Pitarresi G; Carlisi B; A macromolecular prodrug of the known antiretroviral agent zidovudine and alpha, beta-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA) was synthesized. A succinic spacer was present between the polymer and the drug, and 1,1 -carbonyldiimidazole was used as the coupling agent. In vitro drug release studies at pH 1.1, 5.5 a
Induction of type 2 cytokines by a staphylococcal enterotoxin superantigen.: J Nat Toxins. 1998 Oct;7(3):193-213. Unique Identifier : AIDSLINE MED/98456598; Ferens WA; Goff WL; Davis WC; Fox LK; Deobald C; Hamilton MJ; Bohach GA; Department of Microbiology, Molecular Biology and Biochemistry,; University of Idaho, Moscow 83844, USA.; Persistent intramammary infections of dairy cows with Staphylococcus aureus may involve immunosuppression mediated by bacterial toxins such as enterotoxins and other super-antigens (SAgs). Previously we found that stimulation of bovine PBMC with staphylococcal enterotoxin C (SEC) induced a unique phenotype of activate
Social, behavioral, and demographic factors in emerging infections.: J Urban Health. 1998 Sep;75(3):492-500. Unique Identifier : AIDSLINE MED/98435394; Garrett L
Mortality in Hartford, Connecticut: a comparison with the South Bronx, New York.: J Urban Health. 1998 Sep;75(3):550-7. Unique Identifier : AIDSLINE MED/98435397; Polednak AP; Connecticut Department of Public Health, Hartford 06134, USA.; Very high mortality rates have been reported in large inner-city areas such as the South Bronx and Harlem in New York City, but also may occur in smaller US urban areas. Using published death rates for the South Bronx as the standard, the standardized mortality ratio was slightly lower than 1.00 for Hartford, Connecti
Addiction treatment: promoting a medical approach to substance use.: J Urban Health. 1998 Sep;75(3):558-83. Unique Identifier : AIDSLINE MED/98435398; Stein GL; Fleischman AR; Medical and Academic Affairs, New York Academy of Medicine, NY; 10029, USA.
Decreasing cryptosporidiosis among HIV-infected persons in New York City, 1995-1997.: J Urban Health. 1998 Sep;75(3):601-2. Unique Identifier : AIDSLINE MED/98435401; Miller JR
Deaths: final data for 1996.: Natl Vital Stat Rep. 1998 Nov 10;47(9):1-100. Unique Identifier : AIDSLINE MED/99042372; Peters KD; Kochanek KD; Murphy SL; OBJECTIVES: This report presents 1996 data on U.S. deaths and death rates according to demographic and medical characteristics such as age, sex, race, Hispanic origin, marital status, educational attainment, injury at work, State of residence, and cause of death. Trends and patterns in general mortality, life expectan
Usefulness of surface phenotype study of intrathyroidal lymphocytes obtained by fine needle aspiration cytology in autoimmune thyroid disease and malignant lymphoma of the thyroid.: Clin Endocrinol (Oxf). 1998 Aug;49(2):191-6. Unique Identifier : AIDSLINE MED/99046346; Fujikawa M; Okamura K; Sato K; Mizokami T; Tanabe S; Ikenoue H; Okamura S; Ohta M; Fujishima M; Second Department of Internal Medicine, Kyushu University,; Fukuoka, Japan.; OBJECTIVES: The surface phenotypes of intrathyroidal lymphocytes have been studied in various thyroid diseases. In most of the previous reports, intrathyroidal lymphocytes were obtained by surgical operation. We evaluated the usefulness of surface phenotype study of intrathyroidal lymphocytes obtained by fine needle a
Recognition of prostate-specific antigenic peptide determinants by human CD4 and CD8 T cells.: Clin Exp Immunol. 1998 Nov;114(2):166-72. Unique Identifier : AIDSLINE MED/99038066; Corman JM; Sercarz EE; Nanda NK; Department of Microbiology and Molecular Genetics, University of; California, Los Angeles, USA.; It is now becoming accepted that one is not tolerant to all the determinants of self proteins: the T cell repertoire directed to some sequences in self proteins is intact and can be activated. When a self protein is exclusively expressed by tumour cells, the T cell repertoire directed to the particular self antigen ca
Cocaine infusion increases interferon-gamma and decreases interleukin-10 in cocaine-dependent subjects.: Clin Immunol Immunopathol. 1998 Nov;89(2):181-90. Unique Identifier : AIDSLINE MED/99005431; Gan X; Zhang L; Newton T; Chang SL; Ling W; Kermani V; Berger O; Graves MC; Fiala M; Department of Medicine, UCLA School of Medicine, Los Angeles,; California, 90095-1769, USA.; The effects of cocaine infusion (40 mg) on interferon-gamma (IFN-gamma) and interleukin-10 (IL-10) cytokine secretion were examined in 15 cocaine-dependent subjects. Pre- and postcocaine infusion peripheral blood mononuclear cells (PBMC), stimulated with phytohemagglutinin A, were cultured for 48 h and the cytokines i
Hyperkalemic renal tubular acidosis induced by trimethoprim/sulfamethoxazole in an AIDS patient.: Clin Nephrol. 1998 Sep;50(3):188-93. Unique Identifier : AIDSLINE MED/98447319; Sheehan MT; Wen SF; Department of Medicine, University of Wisconsin Center for Health; Sciences, Madison, USA.; A patient with the acquired immunodeficiency syndrome (AIDS) and sickle cell anemia presented to the University of Wisconsin Hospital on two separate occasions with pneumocystis carinii pneumonia (PCP). On both occasions he was treated with high-dose intravenous trimethoprim/sulfamethoxazole (TMP/SMX). Several days in
Indinavir nephropathy in an AIDS patient with renal insufficiency and pyuria.: Unique Identifier : AIDSLINE MED/98447320; Perazella MA; Kashgarian M; Cooney E; Indinavir has been described to cause crystalluria and nephrolithiasis in a variable number of treated patients. Acute renal failure, often reversible with discontinuation of the medication, induction of a diuresis and correction of urinary obstructio
The role of sulphasalazine in African patients with HIV-associated seronegative arthritis [letter]: Clin Exp Rheumatol. 1998 Sep-Oct;16(5):629. Unique Identifier : AIDSLINE MED/98452360; Adebajo AO; Mijiyawa M
Pharmacokinetic modeling of recombinant interleukin-2 in patients with human immunodeficiency virus infection.: Clin Pharmacol Ther. 1998 Nov;64(5):492-8. Unique Identifier : AIDSLINE MED/99049787; Piscitelli SC; Forrest A; Vogel S; Chaitt D; Metcalf J; Stevens R; Baseler M; Davey RT; Kovacs JA; Department of Pharmacy, Clinical Center, National Institutes of; Health, Bethesda, MD 20892, USA. spisc@nih.gov; A novel model was developed to characterize the time-varying clearance of recombinant interleukin-2 ( IL-2 ). Sixty-eight patients with human immunodeficiency virus infection received 83 cycles of IL-2 either by continuous infusion or by subcutaneous injection for 5 days
Frequency of abdominal CT findings in AIDS patients with M. avium complex bacteraemia.: Clin Radiol. 1998 Nov;53(11):816-9. Unique Identifier : AIDSLINE MED/99049530; Pantongrag-Brown L; Krebs TL; Daly BD; Wong-You-Cheong JJ; Beiser C; Krause B; Brown AE; Department of Diagnostic Radiology, University of Maryland; Medical System, Baltimore 21201-1595, USA.; BACKGROUND: Use of blood culture studies for early diagnosis of Mycobacterium avium complex (MAC) infection has become important due to the recent development of effective antibiotic therapy for this condition. This study assessed the abdominal computed tomography (CT) findings in patients with AIDS who presented with
The imaging of Burkitt's and Burkitt-like lymphoma.: Clin Radiol. 1998 Nov;53(11):835-41. Unique Identifier : AIDSLINE MED/99049534; Johnson KA; Tung K; Mead G; Sweetenham J; Department of Radiology, Wessex Oncology Centre, Southampton, UK.; We describe the radiological findings at presentation and follow up in 24 adult patients with Burkitt s and Burkitt-like lymphoma, age range 17-67 years. This is an older age group than previously described in North American series, but the clinical and imaging characteristics appear similar. Disease confined to the a
Powerful AIDS drugs may promote heart disease [news]: Compr Ther. 1998 Sep;24(9):465. Unique Identifier : AIDSLINE MED/99053207
Human immunodeficiency virus-related progressive multifocal leukoencephalopathy with a CD4+ of 444 per mm3: a case report.: Conn Med. 1998 Oct;62(10):579-82. Unique Identifier : AIDSLINE MED/99039162; Lee L; Wu B; Brett-Smith H; Fiedler P; Yale University School of Medicine, New Haven, Brigham and; Women's Hospital, Boston, Massachusetts, USA.; A 47-year-old homosexual man with human immunodeficiency virus infection and CD4+ cell count of 444 per mm3, and with a viral load of 95,720 copies per mL, developed a rapidly progressive cerebellar lesion one month after undergoing coronary artery bypass graft. Diagnostic data were unremarkable with the exception of
Widespread HIV antibody testing of pregnant women--how accurate? [editorial]: Conn Med. 1998 Oct;62(10):621-2. Unique Identifier : AIDSLINE MED/99039169; Melchreit R
Low-dose leukocyte interferon-alpha therapy in dialysed patients with chronic hepatitis C.: Curr Med Res Opin. 1998;14(3):141-4. Unique Identifier : AIDSLINE MED/99004247; Benci A; Caremani M; Menchetti D; Sasdelli M; Giusti PB; Unita Operativa di Medicina Malattie Infettive (Unita Sanitaria; Locale 23), Arezzo, Italy.; Kidney failure is a contraindication to interferon therapy, and active chronic hepatitis is incompatible with kidney transplantation. Our study was aimed at investigating the activity and tolerability of leukocyte interferon-alpha in patients undergoing pre-transplant dialysis and suffering from chronic active hepatit
HIV antibody tests and viral load--more unanswered questions and a further plea for clarification.: Curr Med Res Opin. 1998;14(3):185-6. Unique Identifier : AIDSLINE MED/99004252; Papadopulos-Eleopulos E; Turner VF; Papadimitriou JM; Causer D; Page BA; Department of Medical Physics, Royal Perth Hospital, Western; Australia.
Adjunctive corticosteroid therapy for Pneumocystis carinii pneumonia [editorial; comment]: Chest. 1998 Nov;114(5):1230-1. Unique Identifier : AIDSLINE MED/99039596; Pottratz ST
The impact of comorbidity on mortality following in-hospital diagnosis of tuberculosis.: Chest. 1998 Nov;114(5):1244-52. Unique Identifier : AIDSLINE MED/99039602; Rao VK; Iademarco EP; Fraser VJ; Kollef MH; Department of Internal Medicine, Washington University School of; Medicine, St. Louis, MO 63110, USA.; STUDY OBJECTIVES: Despite the availability of curative chemotherapy, mortality remains high among patients hospitalized for tuberculosis. Although the elevated mortality rate is often attributed to the presence of multidrug resistant tuberculosis (MDRTB) or concomitant infection with the HIV, other factors must be con
The effect of adjunctive corticosteroids for the treatment of Pneumocystis carinii pneumonia on mortality and subsequent complications [see comments]: Chest. 1998 Nov;114(5):1258-63. Unique Identifier : AIDSLINE MED/99039604; Gallant JE; Chaisson RE; Moore RD; Johns Hopkins University School of Medicine, Baltimore, MD; 21287-6220, USA.; OBJECTIVE: To assess the long-term safety of adjunctive corticosteroids in the treatment of Pneumocystis carinii pneumonia (PCP). DESIGN: Analysis of data from a large prospective observational database. SETTING: HIV clinic at a large urban teaching hospital. PATIENTS: One hundred seventy-four patients who developed P
Clearance of Pneumocystis carinii cysts in acute P carinii pneumonia: assessment by serial sputum induction [see comments]: Chest. 1998 Nov;114(5):1264-8. Unique Identifier : AIDSLINE MED/99039605; O'Donnell WJ; Pieciak W; Chertow GM; Sanabria J; Lahive KC; Pulmonary/Critical Care Division, Brigham and Women's Hospital; and Harvard Medical School, Boston, MA, USA. wodonnel@aherf.edu; STUDY OBJECTIVES: To determine the feasibility of repeat sputum induction in acute Pneumocystis carinii pneumonia (PCP) and to define the rate of clearance of P carinii cysts from the respiratory tract of HIV-seropositive patients with acute PCP. DESIGN: Prospective cohort evaluation. SETTING: University medical cente
[Surgical therapy planning and interventions in AIDS (letter)]: Chirurg. 1998 Aug;69(8):889-90. Unique Identifier : AIDSLINE MED/99070587; Muller FP
Comparison of two flow cytometric methods enumerating CD4 T cells and CD8 T cells.: Cytometry. 1998 Sep 1;33(1):76-82. Unique Identifier : AIDSLINE MED/98391377; Storek J; Dawson MA; Maloney DG; Fred Hutchinson Cancer Research Center and University of; Washington, Seattle 98104-2092, USA. jstorek@fhcrc.org; The enumeration of blood CD4+ (single-positive) T cells by flow cytometry is subject to errors such as counting CD4+ monocytes or CD4+CD8+ (double-positive) T cells as CD4+ T cells. Relatively accurate count can be obtained when CD4+ T cells are defined as CD3+CD4+CD8- mononuclear cells (MNCs), using 3-color flow cyto
Specificity of binding of HIV-1 anti-p24 antibodies to CD4+ lymphocytes from HIV-infected subjects.: Cytometry. 1998 Sep 1;33(1):83-8. Unique Identifier : AIDSLINE MED/98391378; Cameron PU; Hunter SD; Jolley D; Sonza S; Mijch A; Crowe SM; Macfarlane Burnet Centre for Medical Research, Fairfield,; Victoria, Australia.; The clinical utility of a flow cytometric assay (FCA) for intracellular HIV p24 antigen was evaluated in a group of HIV-1-infected subjects. A previously described method, p24-FCA (1), was modified to minimize nonspecific staining and to include irrelevant isotype-matched control antibodies. Blood mononuclear cells fr
Anorectal disease in HIV-infected patients.: Dis Colon Rectum. 1998 Nov;41(11):1367-70. Unique Identifier : AIDSLINE MED/99039407; Yuhan R; Orsay C; DelPino A; Pearl R; Pulvirenti J; Kay S; Abcarian H; Division of Colon and Rectal Surgery, Cook County Hospital and; University of Illinois, Chicago 60612, USA.; PURPOSE: Anorectal diseases are common in human immunodeficiency virus-infected individuals. The aim of this prospective study was to assess the cause and clinical presentation of anorectal disease in this human immunodeficiency virus-infected population. METHODS: A registry of all human immunodeficiency virus-seropos
Regression of rectal stenosis secondary to neoplasm in an HIV1-positive patient with gancyclovir antiviral therapy: report of a case.: Dis Colon Rectum. 1998 Nov;41(11):1454-7. Unique Identifier : AIDSLINE MED/99039421; Sobhani I; Babazadeghan BM; Francey AM; Vissuzaine C; Fantin B; Villemant A; Navratil E; Mignon M; Department of Gastroenterology, Bichat Hospital, Paris, France.; PURPOSE: The case of a human immunodeficiency virus-positive patient with rectal stenosis caused by a tumor that completely regressed in response to gancyclovir is presented. METHODS: Several biopsies from the tumoral mass failed to show any stigmata of non-Hodgkin s lymphoma , aden
Cytologic detection of Trichomonas esophagitis in a patient with acquired immunodeficiency syndrome.: Diagn Cytopathol. 1998 Oct;19(4):313-6. Unique Identifier : AIDSLINE MED/99001180; Borczuk AC; Hagan R; Chipty F; Brandt LJ; Department of Pathology, Jacobi Medical Center, Bronx, New York,; USA. alain@mail.webspan.net; Trichomonads are pathogens of the female genital tract and colonizers of the oropharynx. Gastrointestinal and pulmonary diseases have been reported in association with Trichomonas species, but a direct pathogenic effect of this organism in these organ systems remains controversial. Esophageal disease due to trichomona
[Pulmonary tuberculosis in adults: radiological aspects before starting treatment]: Dakar Med. 1996;41(2):115-8. Unique Identifier : AIDSLINE MED/99044343; Niang EH; Badiane M; Ndiaye M; Ka MM; Sano O; Service de Radiologie Generale CHU Dakar.; We studied chest radiological images in 69 patients with tuberculosis, 4 of them were affected by HIV-infection. The sex ratio was 2.63. We observed 177 abnormal pulmonary images associated in different ways. Bilateral and diffuse radiological signs were noted. Tubercular cavern was the most frequent image (92.90%). I
[Hyperkalemia after trimethoprim or pentamidine. Until now, a little noticed side effect of antimicrobial therapeutic measures in AIDS patients]: Dtsch Med Wochenschr. 1998 Nov 6;123(45):1351-5. Unique Identifier : AIDSLINE MED/99052615; Gabriels G; Stockem E; Greven J; Institut fur Pharmakologie und Toxikologie,; Universitatsklinikum, Rheinisch-Westfalische Technische; Hochschule Aachen.
Submandibular gland infection by Mycobacterium avium-intracellulare in an AIDS patient.: Eur J Clin Microbiol Infect Dis. 1998 Jul;17(7):529-35. Unique Identifier : AIDSLINE MED/98435590; Elvira J; Garcia del Rio E; Lopez-Suarez A; Garcia-Martos P; Giron JA; Infectious Diseases Unit, Hospital Universitario Puerta del Mar,; Cadiz, Spain.
Candida and bacterial mandibular osteomyelitis in an AIDS patient.: Eur J Clin Microbiol Infect Dis. 1998 Jul;17(7):531-2. Unique Identifier : AIDSLINE MED/98435591; Sanz-Rodriguez C; Hernandez-Surmann F; Bueno AG; Goizueta C; Noguerado A; Department of Hematology, Hospital Universitario de la Princesa,; Madrid, Spain.
Frequency of the HIV-1 resistance CCR5 deletion allele in Hungarian newborns [letter]: Eur J Pediatr. 1998 Sep;157(9):782. Unique Identifier : AIDSLINE MED/98447439; Szalai C; Czinner A; Csaszar A; Szabo T; Falus A
Homing of mononuclear cells from iliac lymph nodes to the genital and rectal mucosa in non-human primates.: Eur J Immunol. 1998 Oct;28(10):3066-74. Unique Identifier : AIDSLINE MED/99023361; Mitchell EA; Bergmeier LA; Doyle C; Brookes R; Hussain LA; Wang Y; Lehner T; Department of Immunology, United Medical & Dental Schools of; Guy's & St. Thomas' Hospitals, London, GB.; The route of immunization may affect the type of immunity that is induced. The objectives of this investigation were to establish in the non-human primate if the internal iliac lymph nodes (LN) function as an inductive site of immunity from which mononuclear cells home to the rectal and cervico-vaginal mucosa. Rhesus
Secondary but not primary T cell responses are enhanced in CTLA-4-deficient CD8+ T cells.: Eur J Immunol. 1998 Oct;28(10):3137-43. Unique Identifier : AIDSLINE MED/99023368; Chambers CA; Sullivan TJ; Truong T; Allison JP; Howard Hughes Medical Research Institute, Department of Molecular; and Cellular Biology, University of California, Berkeley 94720,; USA.; Negative as well as positive co-stimulation appears to play an important role in controlling T cell activation. CTLA-4 has been proposed to negatively regulate T cell responses. CTLA-4-deficient mice develop a lymphoproliferative disorder, initiated by the activation and expansion of CD4+ T cells. To assess the functi
Dendritic cells from HIV-1-infected patients naturally express HIV-1 gp120 V3 loop-derived peptide ligands.: Eur J Immunol. 1998 Oct;28(10):3144-53. Unique Identifier : AIDSLINE MED/99023369; Fernandez MH; Pitman RJ; Hawrylowicz CM; Rees AD; Department of Genito-Urinary Medicine and Communicable Diseases,; Imperial College of Medicine, London, GB.; Little is known of the peptide ligands expressed in vivo on antigen-presenting cells (APC) or of the APC lineages involved. In this study we have addressed this question using HLA-DRbeta1*0101-restricted CD4 T cell clones (TLC) specific for a synthetic peptide based on the HIV-1 gp120 V3 loop consensus sequence for th
Regulation of T helper cell differentiation in vivo by soluble and membrane proteins provided by antigen-presenting cells.: Eur J Immunol. 1998 Oct;28(10):3161-71. Unique Identifier : AIDSLINE MED/99023371; De Becker G; Moulin V; Tielemans F; De Mattia F; Urbain J; Leo O; Moser M; Departement de Biologie Moleculaire, Universite Libre de; Bruxelles, Rhode-Saint-Genese, Belgium.; The aim of this study was to test whether the nature of the antigen-presenting cell (APC) can influence the Th1/Th2 balance in vivo. Our data show that dendritic cells (DC), pulsed extracorporeally with antigen, induced the development of cells secreting IL-2 , IFN-gamm
Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity.: Eur J Immunol. 1998 Oct;28(10):3183-91. Unique Identifier : AIDSLINE MED/99023373; Jauliac S; Mazerolles F; Jabado N; Pallier A; Bernard F; Peake J; Fischer A; Hivroz C; INSERM U429, Hopital Necker, Enfants Malades, Paris, France.; We have previously shown that CD4 ligands inhibit interleukin-2 ( IL-2 ) production and T cell proliferation in human peripheral CD4+ T lymphocytes, in an MHC-independent way. Two major pathways implicated in T cell activation are inhibited by binding of CD4 ligands to t
Activation of blood T lymphocytes down-regulates CXCR4 expression and interferes with propagation of X4 HIV strains.: Eur J Immunol. 1998 Oct;28(10):3192-204. Unique Identifier : AIDSLINE MED/99023374; Bermejo M; Martin-Serrano J; Oberlin E; Pedraza MA; Serrano A; Santiago B; Caruz A; Loetscher P; Baggiolini M; Arenzana-Seisdedos F; Alcami J; Servico de Microbiologia, Centro de Investigation, Hospital Doce; de Octubre, Madrid, Spain.; The chemokine receptor CXCR4 serves as a coreceptor for HIV-1 entry into CD4+ cells, in particular for strains emerging late in the infection. Cell surface expression of CXCR4 has, therefore, important implications for HIV-1 pathogenesis. Using blood lymphocytes cultured under various conditions, we studied the expres
Decreased IL-12 production and Th1 cell development by acetyl salicylic acid-mediated inhibition of NF-kappaB.: Eur J Immunol. 1998 Oct;28(10):3205-13. Unique Identifier : AIDSLINE MED/99023375; Mazzeo D; Panina-Bordignon P; Recalde H; Sinigaglia F; D'Ambrosio D; Roche Milano Ricerche, Milan, Italy.; IL-12 is a 75-kDa heterodimeric cytokine composed of two covalently linked p35 and p40 chains. This pro-inflammatory cytokine plays a prominent role in the development of Th1 cell-mediated immune responses. Th1 cell-mediated immune responses have been implicated in the pathogenesis of chronic inflammatory autoimmune d
Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC): DC-derived IL-18 enhances IL-12-dependent Th1 development.: Eur J Immunol. 1998 Oct;28(10):3231-9. Unique Identifier : AIDSLINE MED/99023378; Stoll S; Jonuleit H; Schmitt E; Muller G; Yamauchi H; Kurimoto M; Knop J; Enk AH; Department of Dermatology, University of Mainz, Germany.; IL-18 is a recently described cytokine that shares biological activities with IL-12 in driving the development of Th1-type T cells. As dendritic cells (DC) are very potent inducers of T cell proliferation and differentiation we wondered whether they utilize IL-18 as a factor driving Th1 development. We demonstrate by
Role of nerve growth factor in a mouse model of allergic airway inflammation and asthma.: Eur J Immunol. 1998 Oct;28(10):3240-51. Unique Identifier : AIDSLINE MED/99023379; Braun A; Appel E; Baruch R; Herz U; Botchkarev V; Paus R; Brodie C; Renz H; Department of Laboratory Medicine and Pathobiochemistry,; Charite-Virchow Clinic of the Humboldt University, Berlin,; Germany. abraun@ukrv.de; The role of nerve growth factor (NGF), a potent mediator acting in the development and differentiation of both neuronal and immune cells, was examined in a mouse model of allergic asthma. NGF-positive cells were detected in the inflammatory infiltrate of the lung and enhanced levels of NGF were detected in serum and b
Enhanced HIV expression during Th2-oriented responses explained by the opposite regulatory effect of IL-4 and IFN-gamma of fusin/CXCR4.: Eur J Immunol. 1998 Oct;28(10):3280-90. Unique Identifier : AIDSLINE MED/99023383; Galli G; Annunziato F; Mavilia C; Romagnani P; Cosmi L; Manetti R; Pupilli C; Maggi E; Romagnani S; Institute of Internal Medicine and Immunoallergology, University; of Florence, Italy.; The human alpha-chemokine receptor fusin/CXCR4 is an important cofactor for entry of T lymphocyte-tropic HIV-1 strains. We investigated the possible regulatory role of T cell cytokine patterns on CXCR4 as well as HIV expression by using in vitro models of both secondary and primary immune responses. Antigen-specific m
IL-15-IgG2b fusion protein accelerates and enhances a Th2 but not a Th1 immune response in vivo, while IL-2-IgG2b fusion protein inhibits both.: Eur J Immunol. 1998 Oct;28(10):3312-20. Unique Identifier : AIDSLINE MED/99023386; Ruckert R; Herz U; Paus R; Ungureanu D; Pohl T; Renz H; Bulfone-Paus S; Institute for Immunology, University Hospital Benjamin Franklin,; Free University Berlin, Germany.; We have explored how IL-15 influences Th1 or Th2 type immune response in vivo. Intraperitoneal application of an IL-15-IgG2b fusion protein (FP) to mice did neither significantly affect the footpad swelling nor the production of hemagglutinizing antibodies in a delayed type hypersensitivity reaction to sheep red blood
Anti-120-kDa alpha-fodrin immune response with Th1-cytokine profile in the NOD mouse model of Sjogren's syndrome.: Unique Identifier : AIDSLINE MED/99023389; Yanagi K; Ishimaru N; Haneji N; Saegusa K; Saito I; Hayashi Y; Department of Pathology, Tokushima University School of; Dentistry, Japan.; Our recent study suggested that the 120-kDa alpha-fodrin molecule may be an important autoantigen in the pathogenesis of Sjogren s syndrome, and anti-120-kDa alpha-fodrin antibodies have been detected in patients with Sjogren s syndrome. Here we have analyzed anti-120-kDa alpha-fodrin immune responses during developme
Nasal immune system: distinctive Th0 and Th1/Th2 type environments in murine nasal-associated lymphoid tissues and nasal passage, respectively.: Eur J Immunol. 1998 Oct;28(10):3346-53. Unique Identifier : AIDSLINE MED/99023390; Hiroi T; Iwatani K; Iijima H; Kodama S; Yanagita M; Kiyono H; Department of Mucosal Immunology, Research Institute for; Microbial Diseases, Osaka University, Japan.; The nasal mucosa, an important arm of the mucosal immune system, is the first site of contact with inhaled antigens to induce an IgA response. A major aim of this study was to characterize the Th1 and Th2 cytokine expression of mucosal T cells residing in nasal-associated lymphoid tissue (NALT) and nasal passages (NP)
CD40 ligand signals optimize T helper cell cytokine production: role in Th2 development and induction of germinal centers.: Eur J Immunol. 1998 Oct;28(10):3371-83. Unique Identifier : AIDSLINE MED/99023393; Poudrier J; van Essen D; Morales-Alcelay S; Leanderson T; Bergthorsdottir S; Gray D; Department of Immunology, Imperial College School of Medicine,; London, GB.; The role of CD40 in the development of germinal centers (GC) is not simply to initiate the B cell response, as rudimentary GC can develop in CD40-/- mice that are injected with CD40-immunoglobulin (Ig) fusion protein. This indicates that CD40 ligand (CD40L) transduces a signal to T cells that is important in the proce
Enhancement of protective humoral (Th2) and cell-mediated (Th1) immune responses against herpes simplex virus-2 through co-delivery of granulocyte-macrophage colony-stimulating factor expression cassettes.: Eur J Immunol. 1998 Nov;28(11):3530-40. Unique Identifier : AIDSLINE MED/99057030; Sin JI; Kim JJ; Ugen KE; Ciccarelli RB; Higgins TJ; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104, USA.; Granulocyte-macrophage colony-stimulating factor (GM-CSF) could in theory attract antigen-presenting cells in muscle following intramuscular DNA immunization, resulting in enhanced antigen-specific immune responses. Thus, such adjuvants could constitute an important addition to a herpes vaccine by amplifying specific
Defective Th1 and Th2 cytokine synthesis in the T-T cell presentation model for lack of CD40/CD40 ligand interaction.: Eur J Immunol. 1998 Nov;28(11):3552-63. Unique Identifier : AIDSLINE MED/99057032; De Vita L; Accapezzato D; Mangino G; Morrone S; Santilio I; Casciaro MA; Fava D; Bruno G; Del Prete G; Santoni A; Barnaba V; Fondazione Andrea Cesalpino, Istituto di Clinica Medica,; Universita di Roma La Sapienza, Rome, Italy.; In this study, T or NK cell clones used as antigen-presenting cells (T- or NK-APC) were shown to be significantly less efficient than professional APC in inducing Th1 and Th2 cytokines by antigen-specific T cell clones. This phenomenon was not related to a limited engagement of TCR by T-APC, since comparable threshold
Progressive loss of IL-2-expandable HIV-1-specific cytotoxic T lymphocytes during asymptomatic HIV infection.: Eur J Immunol. 1998 Nov;28(11):3564-76. Unique Identifier : AIDSLINE MED/99057033; Jin X; Wills M; Sissons JG; Carmichael A; Department of Medicine, University of Cambridge Clinical School,; Addenbrookes Hospital, GB.; In HIV-1 infection, circulating HIV-1-specific cytotoxic T lymphocytes (CTL) exist in different states of activation, including activated cytotoxic cells and memory cells. We report that a subpopulation of HIV-1-specific CTL is capable of clonal expansion upon culture with
Segregation of type 1 cytokine production in human peripheral blood lymphocytes: phenotypic differences between IFN-gamma and IL-2-producing cells in the CD8+ T cell subset.: Eur J Immunol. 1998 Nov;28(11):3630-8. Unique Identifier : AIDSLINE MED/99057039; Caruso A; Licenziati S; Morelli D; Fiorentini S; Ricotta D; Malacarne F; Sfondrini L; Balsari A; Institute of Microbiology, University of Brescia, Italy.; T cell clones are classified as type 0, 1 or 2 depending on the lymphokines they produce. However, it has remained unclear whether single cells of a given type produce one or several cytokine species. Flow cytometric analysis of peripheral blood lymphocytes (PBL) obtained from 20 healthy donors for the production of t
Cohort study of serum total cholesterol and in-hospital incidence of infectious diseases.: Epidemiol Infect. 1998 Oct;121(2):335-47. Unique Identifier : AIDSLINE MED/99041131; Iribarren C; Jacobs DR Jr; Sidney S; Claxton AJ; Feingold KR; Kaiser Permanente Division of Research, Oakland, CA 94611, USA.; A multiethnic cohort of adult members of the Kaiser Permanente Medical Care Program (55300 men and 65271 women) was followed for 15 years (1979-93) to assess the association between total cholesterol and risk of infections (other than respiratory and HIV) diagnosed in the in-patient setting. Using multivariate Cox reg
A survey of risk factors for cryptosporidiosis in New York City: drinking water and other exposures.: Epidemiol Infect. 1998 Oct;121(2):357-67. Unique Identifier : AIDSLINE MED/99041133; Davis LJ; Roberts HL; Juranek DD; Framm SR; Soave R; Department of Medicine, The New York Hospital-Cornell Medical; Center, NY, USA.; We conducted a survey to determine the prevalence of known and theoretical exposure risks for cryptosporidiosis among selected New York City residents. Subjects were recruited from outpatients attending either a practice for persons with HIV infection (n=160), or other medical practices (n=153), at The New York Hospit
The rate of CD4 decline as a determinant of progression to AIDS independent of the most recent CD4 count. The Italian Seroconversion Study.: Epidemiol Infect. 1998 Oct;121(2):369-76. Unique Identifier : AIDSLINE MED/99041134; Cozzi Lepri A; Sabin CA; Phillips AN; Lee CA; Pezzotti P; Rezza G; Royal Free Centre for HIV Medicine and Department of Primary Care; and Population Sciences, Royal Free and University College; Medical School, University College London, UK.; The data of two cohort studies of HIV-infected individuals were used to examine whether the rate of CD4 decline is a determinant of HIV progression, independent of the most recent CD4 count. Time from seroconversion to clinical AIDS was the main outcome measure. Rates of CD4 decline were estimated using the ordinary l
The risk of infection with HIV and hepatitis B in individuals who inject steroids in England and Wales.: Epidemiol Infect. 1998 Oct;121(2):381-6. Unique Identifier : AIDSLINE MED/99041136; Crampin AC; Lamagni TL; Hope VD; Newham JA; Lewis KM; Parry JV; Gill ON; Department of Public Health and Epidemiology, King's College; School of Medicine and Dentistry, London, UK.; Data on injecting anabolic steroid users, within the national Unlinked Anonymous HIV Prevalence Monitoring Survey of injecting drug users (IDUs) were analysed to determine their risk of acquiring blood borne viruses. One hundred and forty-nine participants who had injected anabolic steroids in the previous month were
Evolution of the cohort study.: Epidemiol Rev. 1998;20(1):1-14. Unique Identifier : AIDSLINE MED/98435253; Samet JM; Munoz A; Department of Epidemiology, School of Hygiene and Public Health,; Johns Hopkins University, Baltimore, MD 21205, USA.
Methodological issues for biomarkers and intermediate outcomes in cohort studies.: Epidemiol Rev. 1998;20(1):29-42. Unique Identifier : AIDSLINE MED/98435255; Munoz A; Gange SJ; Department of Epidemiology, School of Hygiene and Public Health,; Johns Hopkins University, Baltimore, MD 21205, USA.
Retaining and tracking cohort study members.: Epidemiol Rev. 1998;20(1):57-70. Unique Identifier : AIDSLINE MED/98435257; Hunt JR; White E; Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA.; The only way to ensure that losses to follow-up have not biased study results is to keep all losses to an absolute minimum. Since more complete follow-up leads to the identification of additional disease events, the effort spent in locating cohort members also improves the precision as well as the validity of the stud
Aging and lymphocyte subpopulations: whole-blood analysis of immune markers in a large population sample of healthy elderly individuals.: Exp Gerontol. 1998 Sep;33(6):593-600. Unique Identifier : AIDSLINE MED/99006165; Huppert FA; Solomou W; O'Connor S; Morgan K; Sussams P; Brayne C; Department of Psychiatry, University of Cambridge, UK.; Immune status was determined in a representative sample of elderly people by measuring lymphocyte subsets in whole-blood samples as part of an epidemiological study of the population aged 65 and over. Venepuncture was undertaken in more than 500 individuals who took part in an extensive interview that focused on the l
HIV influence on hematopoiesis at the initial stage of infection.: Eur J Haematol. 1998 Oct;61(4):255-60. Unique Identifier : AIDSLINE MED/99036518; Spada C; Treitinger A; Hoshikawa-Fujimura AY; Clinical Analysis Department, Health Sciences Center, UFSC, Santa; Catarina, Brazil. celso@ccs.ufsc.br; Alterations in the parameters responsible for the characteristic anemic condition of AIDS patients who are at the final stage of infection have already been established. However, the development of these alterations at the initial stage of infection, where no opportunistic infections occur, needs further study. The go
Interleukin-15 stimulates the proliferation of peripheral blood leukemic cells from adult T-cell leukemia patients [letter]: Eur J Haematol. 1998 Oct;61(4):278-9. Unique Identifier : AIDSLINE MED/99036522; Mori N; Yamada Y; Tomonaga M; Ikeda S; Yamamoto N
Dual-method use among an ethnically diverse group of women at risk of HIV infection.: Fam Plann Perspect. 1998 Sep-Oct;30(5):212-7. Unique Identifier : AIDSLINE MED/98453304; Riehman KS; Sly DF; Soler H; Eberstein IW; Quadagno D; Harrison DF; UCLA Drug Abuse Research Training Center, UCLA School of; Medicine, Los Angeles, USA.; CONTEXT: Few U.S. women protect themselves against both pregnancy and sexually transmitted diseases (STDs) by using an efficient contraceptive method and a condom. Understanding the factors that influence dual-method use could help improve interventions aimed at encouraging protective behaviors. METHODS: Interviews we
Corneal endothelial precipitates in HIV- and CMV-positive patients without concomitant ocular disease [letter]: Eye. 1998;12 ( Pt 4):743-5. Unique Identifier : AIDSLINE MED/99067264; Miedziak AI; Rapuano CJ; Goldman S
A proposed mechanism for the induction of activator protein 1 (AP-1) binding by HIV-1 negative factor(Nef) in the macrophage cell line RAW267.4 cells.: Biochem Soc Trans. 1998 Aug;26(3):S263. Unique Identifier : AIDSLINE MED/98439119; Biggs T; Barton C; Mann D; Department of Biochemistry, University of Southampton, UK.
Cloning, isolation, expression and mutagenesis studies on the human immuno-deficiency virus type 1 (HIV-1) protease.: Biochem Soc Trans. 1998 Aug;26(3):S287. Unique Identifier : AIDSLINE MED/98439143; Garner JC; Shoolingin-Jordan PM; Division of Biochemistry and Molecular Biology, School of; Biological Sciences, University of Southampton, United Kingdom.
Experience with the Vero cell line.: Dev Biol Stand. 1998;93:119-23. Unique Identifier : AIDSLINE MED/98407404; Montagnon BJ; Vincent-Falquet JC; Pasteur Merieux Serums & Vaccins, Marcy L'Etoile, France.; The Vero cell line has been managed with the Cell Bank system to produce at the 142nd passage IPV, OPV and rabies vaccines since 1982 by Pasteur Merieux Serums & Vaccins (PMsv). The safety of the cell line was regularly validated at the Working Cell Bank (WCB) level according to the WHO and European Pharmacopoeia r
Karyology and tumorigenicity testing requirements: past, present and future.: Dev Biol Stand. 1998;93:5-13. Unique Identifier : AIDSLINE MED/98407389; Petricciani JC; Horaud FN; Genetics Institute, Inc., Cambridge, MA, USA.; At the present time, karyology and tumorigenicity are applied to primary, diploid, and continuous cell systems in an uneven and inappropriate manner, largely for historical reasons. It is a significant anomaly that such rigorous requirements are applied only to diploid cells when, of all three cell types, they represe
Search for SV40 in human mesotheliomas.: Dev Biol Stand. 1998;94:67-8. Unique Identifier : AIDSLINE MED/98447122; Shah KV; Department of Molecular Microbiology and Immunology, Johns; Hopkins University School of Public Health, Baltimore, MD 21205,; USA.
Molecular biology and pathogenesis of human polyomavirus infections.: Dev Biol Stand. 1998;94:71-9. Unique Identifier : AIDSLINE MED/98447123; Dorries K; Institut fur Virologie und Immunobiologie, der; Julius-Maximilians-Universitat Wurzburg, Germany.; The two human polyomaviruses JC and BK are ubiquitous in the human population. Primary infection leads to lifelong persistence in the kidney, the CNS and in lymphoid cells. Virus is shed into the urine and is transmitted at least in part by the oral route. Under limited changes of the immunological state persistent po
[Antalgic treatment of AIDS cholangiopathy with ketoprofen (letter)]: Gastroenterol Clin Biol. 1998 Aug-Sep;22(8-9):746-7. Unique Identifier : AIDSLINE MED/99040905; Mbaye PS; Fall F; Burgel C; Sylla B; Galoo E; Klotz F
Diagnostic yield and cost-effectiveness of endoscopy in chronic human immunodeficiency virus-related diarrhea.: Unique Identifier : AIDSLINE MED/99000045; Bini EJ; Cohen J; BACKGROUND: Endoscopy is commonly performed in patients with chronic human immunodeficiency virus (HIV)-related diarrhea after negative stool studies. The aim of this study was to determine the diagnostic yield and cost-effectiveness of endoscopy in this setting. METHODS: Consecutive HIV-infected patients with chronic
Structural studies of HIV-1 protease-inhibiting antibodies.: Gen Physiol Biophys. 1998 Jun;17 Suppl 1:3-6. Unique Identifier : AIDSLINE MED/99006169; Lescar J; Stouracova R; Riottot MM; Chitarra V; Brynda J; Fabry M; Horejsi M; Sedlacek J; Bentley GA; Unite d'Immunologie Structurale (URA 1961 CNRS), Departement; d'Immunologie, Institut Pasteur, Paris, France.
Anti-HIV proteinase monoclonal antibody F11.2.32 that inhibits enzyme activity.: Gen Physiol Biophys. 1998 Jun;17 Suppl 1:6-8. Unique Identifier : AIDSLINE MED/99006170; Stouracova R; Lescar J; Brynda J; Riottot MM; Chitarra V; Fabry M; Horejsi M; Rezacova P; Bentley G; Sedlacek J; Department of Gene Manipulation, Academy of Sciences of the Czech; Republic, Prague, Czech Republic.
Peptidomimetic inhibitors complexed with HIV-1 protease: crystallisation for X-ray diffraction studies.: Unique Identifier : AIDSLINE MED/99006171; Dohnalek J; Hasek J; Brynda J; Fabry M; Sedlacek J; Konvalinka J
Essential defects of athymic nude mice affect also the nu/+ heterozygotes.: Folia Microbiol (Praha). 1998;43(5):491-2. Unique Identifier : AIDSLINE MED/99038747; Holub M; Necas E; Jiraskova Z; Division of Immunology and Gnotobiology, Academy of Sciences of; the Czech Republic, Prague, Czech Republic.
Enhancement by mild cold stress of the antibody forming capacity in euthymic and athymic hairless mice.: Folia Microbiol (Praha). 1998;43(5):521-3. Unique Identifier : AIDSLINE MED/99038758; Sima P; Cervinkova M; Funda DP; Holub M; Department of Immunology and Gnotobiology, Academy of Sciences of; the Czech Republic, Prague, Czech Republic.
Transgenic mice expressing human HIV receptors become persistently recipient of HIV DNA after injection with infected human cell lines.: Folia Microbiol (Praha). 1998;43(5):525-6. Unique Identifier : AIDSLINE MED/99038759; Simeoni L; Forte P; Aiuti A; Candido A; Campese AF; Fedele G; Di Tommaso F; Navarra M; Fantoni A; Dipartemento Biotecnologie Cellulari ed Ematologia, Universita; di Roma La Sapienza, Italy.
HIV-associated lymphoepithelial cysts and lesions: morphological and immunohistochemical study of the lymphoid cells.: Histopathology. 1998 Sep;33(3):222-9. Unique Identifier : AIDSLINE MED/98450563; Chetty R; Department of Pathology, University of Natal School of Medicine,; Durban, South Africa.; AIMS: To determine the morphology, immunophenotype and bcl-2 protein status of intraepithelial lymphocytes in HIV-positive lymphoepithelial lesions. METHODS AND RESULTS: Seventeen cases (from adults and children) of HIV-associated parotid and lung lymphoid lesions were examined. In addition, three lymphoepithelial cys
Endogenous IL-10 regulates IFN-gamma and IL-5 cytokine production and the granulomatous response in Schistosomiasis mansoni-infected mice.: Immunology. 1998 Aug;94(4):481-7. Unique Identifier : AIDSLINE MED/98440380; Boros DL; Whitfield JR; Department of Immunology and Microbiology, Wayne State; University, School of Medicine, Detroit MI 48201, USA.; In murine Schistosomiasis mansoni circumovum, granuloma formation is regulated by pro- and anti-inflammatory cytokines. Among the latter, interleukin-10 (IL-10) has been shown to regulate the inflammatory response. In this study we examined the role of endogenously produced IL-10 in T-helper 1 (Th1)- and Th2-type cyto
Immunodeficiency associated with anorexia nervosa is secondary and improves after refeeding.: Immunology. 1998 Aug;94(4):543-51. Unique Identifier : AIDSLINE MED/98440388; Allende LM; Corell A; Manzanares J; Madruga D; Marcos A; Madrono A; Lopez-Goyanes A; Garcia-Perez MA; Moreno JM; Rodrigo M; Sanz F; Arnaiz-Villena A; Department of Immunology, Hospital Universitario 12 de Octobre,; Madrid, Spain.; Several studies have addressed the question of starvation effects on immune function by means of changes in lymphocyte subsets, cytokine induction or lymphocyte activation. Anorexia nervosa (AN) patients are severely malnourished and contradictory results have been obtained regarding the accompanying immunodeficiency,
Functional aspects of iscoms.: Immunol Cell Biol. 1998 Aug;76(4):295-9. Unique Identifier : AIDSLINE MED/98389163; Morein F; Bengtsson KL; Swedish University of Agricultural Science, Department of; Veterinary Microbiology, Biomedical Center, Uppsala, Sweden.; The iscom is a delivery system, designed for both parenteral and mucosal modes of administration, for both antigens and adjuvants, components which are interchangeable. By the parenteral route a prominent systemic Th1 type of response is evoked, but the mucosal immunoglobulin A (IgA) response was insignificant. Intran
Different effect of 1,25-dihydroxyvitamin D3 on replication of Mycobacterium avium in monocyte-derived macrophages from human immunodeficiency virus-infected subjects and healthy controls.: Immunol Lett. 1998 Sep;63(2):107-12. Unique Identifier : AIDSLINE MED/98432539; Haug CJ; Muller F; Aukrust P; Froland SS; Institute for Internal Medicine, Medical Department A, University; of Oslo, The National Hospital-Rikshospitalet, Norway.; charlotte.haug@basalmed.uio.no; Mycobacterium avium complex (MAC) is the most common cause of disseminated bacterial infection in patients with acquired immune deficiency syndrome (AIDS) and macrophage dysfunction is important both in the pathogenesis of AIDS- and MAC-infection. 1,25-Dihydroxyvitamin D3 (1,25D), the active metabolite of vitamin D, h
Activation of CD4+ and CD8+ parasite -specific T-cells by macrophages infected with live T. cruzi amastigotes.: Immunol Lett. 1998 Sep;63(2):97-105. Unique Identifier : AIDSLINE MED/98432538; Caulada-Benedetti Z; Vecchio LC; Pardi CC; Massironi SM; D'Imperio Lima MR; Abrahamsohn IA; Departamento de Immunologia, Instituto de Ciencias Biomedicas,; Edifico Biomedicas IV, Cidade Universitaria, Universidade de; Sao Paulo, SP, Brazil. caulada@ibm.net; T. cruzi-infected macrophages are potential candidates for the presentation of parasite antigens to T. cruzi-specific T lymphocytes. To assess this question, we examine the ability of peritoneal exudate macrophages to process exogenous live or dead parasites and to activate defined populations of T. cruzi-specific imm
T cell receptor V-segment frequencies in peripheral CD8+ T cells in aging.: Immunol Invest. 1998 Jul-Sep;27(4-5):303-7. Unique Identifier : AIDSLINE MED/98397827; Esparza B; Rodriguez A; Puente M; Sabino E; Merino F; Department of Physiology, School of Medicine, Universidad del; Pais Vasco, Bilbao, Spain.; Infections are a major cause of illness and death amongst elderly people. Peripheral blood CD8+ T lymphocytes --which play a crucial role in host defence against viral infections--, are divided in subsets based upon the expression of several cell and activation markers. In senescence changes and variations in peripher
Kala Azar and HIV [editorial]: Indian J Pathol Microbiol. 1998 Jul;41(3):269-70. Unique Identifier : AIDSLINE MED/99022688; Shahi SK; Ranga S; Khurana SK; Talib VH
Lack of association of gestational trophoblastic diseases (GTD) with syphilis and AIDS.: Indian J Pathol Microbiol. 1998 Jul;41(3):277-9. Unique Identifier : AIDSLINE MED/99022690; Swapna E; Molykutty J; Rajalekshmy TN; Vijayasree SR; Krishnan NM; Prabha B; Research Division, Regional Cancer Centre, Thiruvanathapuram,; Kerala.; The association between human immunodeficiency virus (HIV) infection and syphilis infection as an etiological factor in Gestational Trophoblastic Disease (GTD) was investigated by means of micro-enzyme linked immunosorbent assay (Micro-ELISA) and Treposcreen-Rapid Plasma Reagin Card Test in 138 sera from patients with
Randomized, double-blind, placebo-controlled trial of the immune modulator WF10 in patients with advanced AIDS.: Infection. 1998 Jul-Aug;26(4):202-7. Unique Identifier : AIDSLINE MED/98383421; Raffanti SP; Schaffner W; Federspiel CF; Blackwell RB; Ching OA; Kuhne FW; Dept. of Medicine, Vanderbilt School of Medicine, Nashville, TN; 37232-2637, USA.; A randomized, double-blind trial compared treatment with the immune modulator WF10 (ten patients) and placebo (nine patients) administered in cycles over 3 months among individuals with advanced AIDS. There were no notable clinical adverse events; changes in hematologic and chemistry values were comparable in the two
Painful hyperaesthesia caused by protease inhibitors? [letter]: Infection. 1998 Jul-Aug;26(4):250-1. Unique Identifier : AIDSLINE MED/98383431; Colebunders R; De Droogh E; Pelgrom Y; Depraetere K; De Jonghe P
Nelfinavir associated with peripheral neuropathy in an HIV-infected patient [letter]: Infection. 1998 Jul-Aug;26(4):252. Unique Identifier : AIDSLINE MED/98383432; Grunke M; Kraetsch HG; Low P; Rascu A; Kalden JR; Harrer T
Simian-virus-40 footprints in human lymphoproliferative disorders of HIV- and HIV+ patients.: Int J Cancer. 1998 Dec 9;78(6):669-74. Unique Identifier : AIDSLINE MED/99049503; Martini F; Dolcetti R; Gloghini A; Iaccheri L; Carbone A; Boiocchi M; Tognon M; Department of Morphology and Embryology, University of Ferrara,; Italy.; SV40 sequences were investigated by PCR DNA amplification followed by filter hybridization in a series of human lymphoproliferative disorders obtained from human-immunodeficiency-virus (HIV)-seronegative and HIV-infected patients. Our PCR and filter-hybridization conditions enabled us to detect SV40 sequences in the r
Circulating Melan-A/Mart-1 specific cytolytic T lymphocyte precursors in HLA-A2+ melanoma patients have a memory phenotype.: Int J Cancer. 1998 Dec 9;78(6):699-706. Unique Identifier : AIDSLINE MED/99049508; D'Souza S; Rimoldi D; Lienard D; Lejeune F; Cerottini JC; Romero P; Multidisciplinary Oncology Center, CHUV, Lausanne, Switzerland.; Melan-A/MART-1 is a melanoma differentiation antigen that is recognized by a high proportion of cytolytic T lymphocyte (CTL) clones derived from human leukocyte antigen (HLA)-A2+ melanoma patients. Whereas peptide Melan-A/ MART-1(27-35) was originally defined as the immunodominant CTL epitope, we have previously repor
Ethanol treatment of tendon allografts: a potential HIV inactivating procedure.: Int Orthop. 1998;22(4):252-4. Unique Identifier : AIDSLINE MED/99011906; Anastasescou M; Cornu O; Banse X; Konig J; Hassoun A; Delloye C; Orthopaedic Research Laboratory, Catholic University of Louvain,; Brussels, Belgium.; The penetration rate of ethanol in human tendons was studied to in order to define the conditions which were necessary to achieve an inactivating concentration against the Human Immunodeficiency Virus (HIV) within the tendon. The rate of alcohol penetration was found to be slow and did not differ with different types
Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) mortality in industrialized nations, 1987-1991.: Int J Epidemiol. 1998 Aug;27(4):685-90. Unique Identifier : AIDSLINE MED/98429093; Heath KV; Frank O; Montaner JS; O'Shaughnessy MV; Schechter MT; Hogg RS; British Columbia Centre for Excellence in HIV/AIDS, St Paul's; Hospital, Vancouver, Canada.; OBJECTIVE: To compare patterns of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) mortality in 11 selected industrialized countries with highly developed death registration systems and a broad range of cumulative AIDS incidence rates. METHODS: Data on HIV/AIDS mortality were obtained from
Socioeconomic geographical links to human immunodeficiency virus seroprevalence among childbearing women in Montreal, 1989-1993.: Int J Epidemiol. 1998 Aug;27(4):691-7. Unique Identifier : AIDSLINE MED/98429094; Hankins C; Tran T; Hum L; Laberge C; Lapointe N; Lepine D; Montpetit M; O'Shaughnessy MV; Infectious Disease Unit, Montreal Regional Public Health; Department, Quebec, Canada.; BACKGROUND: To describe the socioeconomic profiles of geographical areas on Montreal Island in which human immunodeficiency virus (HIV) seropositive women delivering live births between 1989 and 1993 reside. METHODS: Leftover dried blood spot filter paper specimens collected from newborns were irretrievably unlinked f
Causes of death in a rural, population-based human immunodeficiency virus type 1 (HIV-1) natural history cohort in Uganda.: Int J Epidemiol. 1998 Aug;27(4):698-702. Unique Identifier : AIDSLINE MED/98429095; Okongo M; Morgan D; Mayanja B; Ross A; Whitworth J; Medical Research Council Programme on AIDS/Uganda Virus Research; Institute, Entebbe.; BACKGROUND: While human immunodeficiency virus (HIV)-related causes of death have been well documented in developed countries, in Africa data are scanty and mainly based on autopsy studies from city hospitals which are highly selective and may not represent causes of HIV-associated deaths in the general population. Th
CD4+ lymphocytes and tuberculin skin test as survival predictors in pulmonary tuberculosis HIV-infected patients.: Int J Epidemiol. 1998 Aug;27(4):703-12. Unique Identifier : AIDSLINE MED/98429096; Serrat C; Gomez G; Garcia de Olalla P; Cayla JA; Universitat Politecnica de Catalunya, Barcelona, Spain.; BACKGROUND: We analyse whether the tuberculin skin test is a good survival marker in a cohort of pulmonary tuberculosis patients with HIV infection (PTB/HIV). In all, 494 PTB/HIV patients were enrolled in Barcelona ( Spain ) between January 1992 and December 1994 in the Tuberculosis P
Otitis media in children with vertically-acquired HIV infection: the Great Ormond Street Hospital experience.: Int J Pediatr Otorhinolaryngol. 1998 Sep 15;45(1):69-75. Unique Identifier : AIDSLINE MED/99019167; Shapiro NL; Novelli V; Pediatric Otolaryngology, Division of Head and Neck Surgery, UCLA; School of Medicine, Los Angeles, California 90095-1624, USA.; Human immunodeficiency virus (HIV) infection continues to be a vexing problem in the pediatric population. Otitis media, a common entity in immunocompetent as well as immunocompromised children, is prevalent in pediatric patients with HIV infection. Recurrent infections and complications secondary to otitis media are
Drugs for AIDS/HIV: assessing the evidence.: Int J Technol Assess Health Care. 1998 Summer;14(3):567-72. Unique Identifier : AIDSLINE MED/98453827; Jones JL; This article highlights factors that may cause bias in individual controlled trials or meta-analysis of zidovudine ( AZT ) in HIV disease. The overall benefit of AZT and antiretroviral drug combinations in the progression of HIV disease is probably grea
Effect of a traditional Chinese medicine, Bu-zhong-yi-qi-tang on the protection against an oral infection with Listeria monocytogenes.: Immunopharmacology. 1998 Jun;39(3):215-23. Unique Identifier : AIDSLINE MED/98425902; Yamaoka Y; Kawakita T; Kishihara K; Nomoto K; Traditional Chinese Medicine Research Laboratories, Kanebo,; Osaka, Japan.; The protective effect against an oral infection with Listeria monocytogenes was observed in BALB/c mice who were orally administered a traditional Chinese medicine, Bu-zhong-yi-qi-tang (Japanese name: Hochu-ekki-to, HOT) daily for 7 days. Bacterial numbers in the Peyer s patch (PP) at 18 h, in the mesenteric lymph nod
Treatment for AIDS [news]: J Am Osteopath Assoc. 1998 Oct;98(10):529. Unique Identifier : AIDSLINE MED/99039171
From the NIH. AIDS-related deaths decline [news]: J Am Osteopath Assoc. 1998 Oct;98(10):546. Unique Identifier : AIDSLINE MED/99039177
Prevention of perinatal transmission of HIV in Arkansas.: J Ark Med Soc. 1998 Nov;95(6):239-41. Unique Identifier : AIDSLINE MED/99039186; Darville T; Matheney R; Tucker NC; Department of Pediatrics, UAMS/Arkansas Children's Hospital, USA.; In 1994, the Centers for Disease Control and Prevention (CDC) recommended zidovudine (ZDV) prophylaxis to reduce perinatal transmission of HIV. Caregivers at the University of Arkansas for Medical Sciences (UAMS) instituted a program of universal voluntary HIV testing of pregnant females combined with maternal educati
Processing of an HIV replication intermediate by the human DNA replication enzyme FEN1.: J Biol Chem. 1998 Oct 30;273(44):28740-5. Unique Identifier : AIDSLINE MED/99003217; Rumbaugh JA; Fuentes GM; Bambara RA; Department of Biochemistry, University of Rochester School of; Medicine and Dentistry, Rochester, New York 14642, USA.; The role of human FEN1 (flap endonuclease-1), an RTH1 (RAD two homolog-1) class nuclease, in the replication of human immunodeficiency virus (HIV) type 1 has been examined using model substrates. FEN1 is able to endonucleolytically cleave a primer annealed to a template, but with a 5 -unannealed tail. The HIV (+)-stra
Mitogen-activated protein kinase phosphorylates and regulates the HIV-1 Vif protein.: J Biol Chem. 1998 Nov 6;273(45):29879-87. Unique Identifier : AIDSLINE MED/99009106; Yang X; Gabuzda D; Department of Cancer Immunology & AIDS, Dana-Farber Cancer; Institute, Boston, Massachusetts 02115, USA.; The human immunodeficiency virus type 1 (HIV-1) Vif protein plays a critical role in virus replication and infectivity. Here we show that Vif is phosphorylated and regulated by p44/42 mitogen-activated protein kinase (MAPK). Vif phosphorylation by MAPK was demonstrated in vitro as well as in vivo and was shown to occu
Vertical-scanning mutagenesis of a critical tryptophan in the minor groove binding track of HIV-1 reverse transcriptase. Molecular nature of polymerase-nucleic acid interactions.: J Biol Chem. 1998 Nov 13;273(46):30435-42. Unique Identifier : AIDSLINE MED/99023971; Beard WA; Bebenek K; Darden TA; Li L; Prasad R; Kunkel TA; Wilson SH; Laboratory of Structural Biology, National Institute of; Environmental Health Sciences, Research Triangle Park, North; Carolina 27709, USA.; While sequence-specific DNA-binding proteins interact predominantly in the DNA major groove, DNA polymerases bind DNA through interactions in the minor groove that are sequence nonspecific. Through functional analyses of alanine-substituted mutant enzymes that were guided by molecular dynamics modeling of the human im
EDF-1, a novel gene product down-regulated in human endothelial cell differentiation.: J Biol Chem. 1998 Nov 20;273(47):31119-24. Unique Identifier : AIDSLINE GENBANK/AJ005259; Dragoni I; Mariotti M; Consalez GG; Soria MR; Maier JA; Dipartimento di Scienze e Tecnologie Biomediche-Ospedale San; Raffaele, Universita di Milano, I-20132 Milano, Italy.; Endothelial cell differentiation is a crucial step in angiogenesis. Here we report the identification of EDF-1, a novel gene product that is down-regulated when endothelial cells are induced to differentiate in vitro. The cDNA encoding EDF-1 was isolated by RNA fingerprinting from human endothelial cells exposed to hu
Regulation of carboxyl-terminal domain phosphatase by HIV-1 tat protein.: J Biol Chem. 1998 Nov 27;273(48):31726-30. Unique Identifier : AIDSLINE MED/99041929; Marshall NF; Dahmus GK; Dahmus ME; Section of Molecular and Cellular Biology, Division of Biological; Sciences, University of California, Davis, California 95616, USA.; The phosphorylation state of the carboxyl-terminal domain (CTD) of RNA polymerase (RNAP) II is directly linked to the phase of transcription being carried out by the polymerase. Enzymes that affect CTD phosphorylation can thus play a major role in the regulation of transcription. A previously characterized HeLa CTD ph
Characterization of HIV-1 vpr nuclear import: analysis of signals and pathways.: Unique Identifier : AIDSLINE MED/99034580; Jenkins Y; McEntee M; Weis K; Greene WC; While the Vpr protein of HIV-1 has been implicated in import of the viral preintegration complex across the nuclear pore complex (NPC) of nondividing cellular hosts, the mechanism by which Vpr enters the nucleus remains unknown. We now demonstrate that Vpr contains two discrete nuclear targeting signals that use two d
Differential regulation of CXCR4 and CCR5 endocytosis.: J Cell Sci. 1998 Sep;111 ( Pt 18):2819-30. Unique Identifier : AIDSLINE MED/98386162; Signoret N; Rosenkilde MM; Klasse PJ; Schwartz TW; Malim MH; Hoxie JA; Marsh M; Medical Research Council Laboratory for Molecular Cell Biology; and Department of Biochemistry, University College London, Gower; Street, London WC1E 6BT, UK.; The chemokine receptors CCR5 and CXCR4 are major co-receptors/receptors for the CD4-dependent and CD4-independent entry of human and simian immunodeficiency viruses. The chemokines that bind and activate these receptors can inhibit the entry of viruses that use the respective co-receptor molecules. Chemokine-induced c
CD8 T cells in HIV infection: mechanisms of immunity.: Hosp Pract (Off Ed). 1998 Nov 15;33(11):105-8, 111-2, 115-7 passim. Unique Identifier : AIDSLINE MED/99044197; Yang OO; AIDS Research Center/Infectious Disease Unit, Massachusetts; General Hospital, Boston, USA.; CD8 lymphocytes probably play a key role in the immunologic defense against HIV. The evidence is that they control viral replication by at least two mechanisms: direct antigen-specific cytolysis, which appears to be required for optimal suppression, and release of soluble antiviral factors. New therapeutic strategies
Isolation of a retrovirus from multiple sclerosis patients in self-generated Iodixanol gradients.: J Virol Methods. 1998 Aug;73(2):151-61. Unique Identifier : AIDSLINE MED/98438276; Moller-Larsen A; Christensen T; Institute of Medical Microbiology, University of Aarhus, Aarhus; C, Denmark.; The use of Iodixanol, a relatively new iodinated gradient medium, is described for isolation of a retrovirus, which was harvested from the supernatant of lymphoid cell lines originating from patients with multiple sclerosis (MS). The virus is produced in low amounts and has been shown to be fragile, as manifested in a
A novel and innovative quantitative kinetic software for virological colorimetric assays.: J Virol Methods. 1998 Aug;73(2):201-9. Unique Identifier : AIDSLINE MED/98438281; Giacomini M; McDermott JL; Giri AA; Martini I; Lillo FB; Varnier OE; Molecular Virology Unit, Advanced Biotechnology Center, Genova,; Italy. giacomin@dist.unige.it; This study addresses the limited range of quantification with colorimetric assays (ELISA) starting from the analysis of color production in a reference external curve. An automatic ELISA management software, designated Quanti-Kin Detection System (QKDS) is described, which retains the sensitivity of the end-point read
Purification of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) and analyses of the structural proteins.: J Virol Methods. 1998 Aug;73(2):219-28. Unique Identifier : AIDSLINE MED/98438283; Wang YC; Zhang Q; Montalvo EA; Department of Pediatrics, The University of Texas Health Science; Center at San Antonio, 78284, USA.; The Kaposis s sarcoma-associated herpesvirus (KSHV) infected BCBL-1 cell line, adapted to and grown in medium containing 10% horse serum, was induced to lytic replication with 12-O-tetradecanoylphorbol-13-acetate (TPA) for virus production. Supernatants from induced cells were filtered through a 0.45-microm filter and
Effect of interleukin (IL)-12 and IL-15 on activated natural killer (ANK) and antibody-dependent cellular cytotoxicity (ADCC) in HIV infection.: J Clin Immunol. 1998 Sep;18(5):335-45. Unique Identifier : AIDSLINE MED/99010241; Lin SJ; Roberts RL; Ank BJ; Nguyen QH; Thomas EK; Stiehm ER; Department of Pediatrics, UCLA Children's Hospital 90095, USA.; The ability of IL-12 and IL-15 to enhance natural killer (NK) activity and antibody-dependent cellular cytotoxicity (ADCC) of mononuclear cells (MNCs) from HIV+ children and their mothers was investigated. MNCs from HIV+ patients were deficient in NK and ADCC activity compared to control MNCs against several target ce
Lack of immunotoxicity of saquinavir (Ro 31-8959) used alone or in double or triple combination with AZT and ddC.: Unique Identifier : AIDSLINE MED/99010242; Viora M; Di Genova G; Quaranta MG; Boirivant M; Camponeschi B; Immunology Department, Istituto Superiore di Sanita, Roma,; Italy.; Saquinavir (Ro 31-8959; SQV) has been demonstrated to be a potent inhibitor of human immunodeficiency virus (HIV) proteinases and acts synergistically with dideoxynucleoside analogues. The aim of this study was to investigate the in vitro immunomodulatory effects of SQV on normal human peripheral blood mononuclear cel
Cutaneous aspergillosis.: J Clin Microbiol. 1998 Nov;36(11):3115-21. Unique Identifier : AIDSLINE MED/98449822; van Burik JA; Colven R; Spach DH; Department of Medicine, Division of Allergy and Infectious; Diseases, Seattle, Washington, USA. jvanburi@fhcrc.org
Antigenemia in patients with paracoccidioidomycosis: detection of the 87-kilodalton determinant during and after antifungal therapy.: J Clin Microbiol. 1998 Nov;36(11):3309-16. Unique Identifier : AIDSLINE MED/98449857; Gomez BL; Figueroa JI; Hamilton AJ; Diez S; Rojas M; Tobon AM; Hay RJ; Restrepo A; Corporacion para Investigaciones Biologicas, Facultad de; Medicina, Universidad de Antioquia, Medellin, Colombia.; Serological diagnosis and follow-up of paracoccidioidomycosis (PCM) patients have relied mainly on the detection of antibody responses by using techniques such as complement fixation (CF) and immunodiffusion. We recently described a novel inhibition enzyme-linked immunosorbent assay (inh-ELISA) which proved to be usef
PCR method for detection of adenovirus in urine of healthy and human immunodeficiency virus-infected individuals.: J Clin Microbiol. 1998 Nov;36(11):3323-6. Unique Identifier : AIDSLINE MED/98449859; Echavarria M; Forman M; Ticehurst J; Dumler JS; Charache P; Division of Medical Microbiology, Department of Pathology, The; Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.; Adenoviruses (AdV) cause diseases that range from localized, self-limited illnesses to fatal infections in immunocompromised patients. Culture is assumed to be sensitive but requires viable virus and up to 3 weeks for detection, and it can be inhibited by bacterial contamination. A new PCR method amplifying a region o
Comparison of costs of strategies for measuring levels of human immunodeficiency virus type 1 RNA in plasma by using Amplicor and Ultra Direct assays.: J Clin Microbiol. 1998 Nov;36(11):3369-71. Unique Identifier : AIDSLINE MED/98449870; Raboud JM; Seminari E; Rae SL; Harrigan PR; Hogg RS; Conway B; Sherlock C; Schechter MT; O'Shaughnessy MV; Montaner JSG; Canadian HIV Trials Network, University of British Columbia,; Vancouver, British Columbia, Canada. jraboud@hivnet.ubc.ca; The costs of four algorithms for monitoring plasma human immunodeficiency virus type 1 RNA were compared. For patients with strong virologic responses, the use of Ultra Direct exclusively was the cheapest strategy. For patients with weak virologic responses, small savings could be obtained by using Amplicor and retest
Evaluation of the Nuclisens HIV-1 QT assay for quantitation of human immunodeficiency virus type 1 RNA levels in plasma.: J Clin Microbiol. 1998 Nov;36(11):3372-4. Unique Identifier : AIDSLINE MED/98449871; Segondy M; Ly TD; Lapeyre M; Montes B; Laboratoire de Virologie, Centre Hospitalier Universitaire de; Montpellier, Montpellier, France. msegondy@worldnet.fr; Nuclisens HIV-1 QT is a new version of the NASBA HIV-1 QT assay for quantitation of human immunodeficiency virus type 1 (HIV-1) RNA in plasma. The specificity of this assay was 100% in one laboratory and 99%-with nonrepeatability of the initial false positive-in another. The test was linear between 2.0 and 6.0 log RNA
First isolation of Trichophyton fischeri in the United States.: J Clin Microbiol. 1998 Nov;36(11):3389-91. Unique Identifier : AIDSLINE MED/98449876; Rosenthal SA; Scott JS; Summerbell RC; Kane J; New York University Medical Center, New York, New York, USA.; A 49-year-old male with Pneumocystis carinii pneumonia was seen at Bellevue Hospital in New York, N.Y. Sputum samples yielded cultures of Candida lusitaniae, Mycobacterium avium, and a filamentous fungus, Trichophyton fischeri. T. fischeri is a nonpathogenic fungus which resembles the dermatophyte Trichophyton rubrum.
Comparison of the QUANTIPLEX HIV-1 RNA 2.0 assay with the AMPLICOR HIV-1 MONITOR 1.0 assay for quantitation of levels of human immunodeficiency virus type 1 RNA in plasma of patients receiving stavudine-didanosine combination therapy.: J Clin Microbiol. 1998 Nov;36(11):3392-5. Unique Identifier : AIDSLINE MED/98449877; Segondy M; Izopet J; Pellegrin I; Montes B; Dumon B; Pasquier C; Peeters M; Fleury HJ; Puel J; Reynes J; Department of Virology and Department of Infectious and Tropical; Diseases, Montpellier University Hospital, Montpellier, France.; msegondy@worldnet.fr; We compared the QUANTIPLEX HIV-1 RNA 2.0 assay with the AMPLICOR HIV-1 MONITOR 1.0 assay for quantitation of human immunodeficiency virus type 1 (HIV-1) RNA in plasma in the Stadi trail, which evaluated a stavudine plus didanosine
Evaluation of a leukocyte stabilization reagent for use in the cytomegalovirus pp65 antigenemia assay.: J Clin Microbiol. 1998 Nov;36(11):3410-1. Unique Identifier : AIDSLINE MED/98449881; Bush CE; Sluchak-Carlsen JA; Division of Infectious Diseases, Department of Internal Medicine,; Henry Ford Hospital, Detroit, Michigan, USA. CEBUSHDON@AOL.COM; New erythrocyte lysis and leukocyte stabilization reagents (Streck Laboratories, Inc.) were tested in the cytomegalovirus pp65 antigenemia assay, to determine if whole-blood processing time could be delayed to 24 h postdraw. The combination of these reagents gave results comparable
Fluconazole disk diffusion susceptibility testing of Candida species.: J Clin Microbiol. 1998 Nov;36(11):3429-32. Unique Identifier : AIDSLINE MED/98449888; Kirkpatrick WR; Turner TM; Fothergill AW; McCarthy DI; Redding SW; Rinaldi MG; Patterson TF; Departments of Medicine, The University of Texas Health Science; Center at San Antonio, San Antonio, Texas 78284, USA.; We describe a simple procedure for detecting fluconazole-resistant yeasts by a disk diffusion method. Forty clinical Candida sp. isolates were tested on RPMI-glucose agar with either 25- or 50-microgram fluconazole disks. With 25-microgram disks, zones of inhibition of >/=20 mm at 24 h accurately identified 29 of 29 i
Rapid immunochromatographic assay for diagnosis of tuberculosis [letter]: J Clin Microbiol. 1998 Nov;36(11):3443. Unique Identifier : AIDSLINE MED/99066535; Grobusch MP; Schurmann D; Schwenke S; Teichmann D; Klein E
Armored RNA technology for production of ribonuclease-resistant viral RNA controls and standards.: J Clin Microbiol. 1998 Dec;36(12):3590-4. Unique Identifier : AIDSLINE MED/99036764; Pasloske BL; Walkerpeach CR; Obermoeller RD; Winkler M; DuBois DB; Ambion, Inc., Austin, Texas 78744, USA. bpasloske@ambion.com; The widespread use of sensitive assays for the detection of viral and cellular RNA sequences has created a need for stable, well-characterized controls and standards. We describe the development of a versatile, novel system for creating RNase-resistant RNA. Armored RNA is a complex of MS2 bacteriophage coat protein
Comparison of two measures of human immunodeficiency virus (HIV) type 1 load in HIV risk groups.: J Clin Microbiol. 1998 Dec;36(12):3647-52. Unique Identifier : AIDSLINE MED/99036775; Lyles CM; Vlahov D; Farzadegan H; Astemborski J; Margolick JB; Masters BA; Schroeder J; Quinn TC; Departments of Epidemiology, The Johns Hopkins School of Hygiene; and Public Health, Baltimore, Maryland, USA. clyles@jhsph.edu; Levels of viral burden were compared across risk group and gender populations among 485 human immunodeficiency virus type 1 (HIV-1)-infected participants consisting of 190 male injection drug users (IDUs), 92 female IDUs, and 203 homosexual men. Viral burden was quantified by a microculture technique to determine cell
Rapid assay for simultaneous detection and differentiation of immunoglobulin G antibodies to human immunodeficiency virus type 1 (HIV-1) group M, HIV-1 group O, and HIV-2.: J Clin Microbiol. 1998 Dec;36(12):3657-61. Unique Identifier : AIDSLINE MED/99036777; Vallari AS; Hickman RK; Hackett JR Jr; Brennan CA; Varitek VA Jr; Devare SG; AIDS Research and Retrovirus Discovery, Abbott Laboratories,; North Chicago, Illinois, 60064-4000, USA.; ana.vallariadd.ssw.abbott.com; A rapid immunodiagnostic test that detects and discriminates human immunodeficiency virus (HIV) infections on the basis of viral type, HIV type 1 (HIV-1) group M, HIV-1 group O, or HIV-2, was developed. The rapid assay for the detection of HIV (HIV rapid assay) was designed as an instrument-free chromatographic immuno
Sequence variation within three important cytomegalovirus gene regions in isolates from four different patient populations.: J Clin Microbiol. 1998 Dec;36(12):3662-9. Unique Identifier : AIDSLINE MED/99036778; Zweygberg Wirgart B; Brytting M; Linde A; Wahren B; Grillner L; Department of Clinical Microbiology, Section of Virology,; Karolinska Hospital, S-171 76, Stockholm, Sweden. benita@mb.ks.se; We determined the nucleotide (nt) and amino acid (aa) heterogeneities of three distinct regions of the human cytomegalovirus ( CMV ) genome for 46 low-passage CMV isolates from four different patient populations (congenitally i
Typing of human Mycobacterium avium isolates in Italy by IS1245-based restriction fragment length polymorphism analysis.: J Clin Microbiol. 1998 Dec;36(12):3694-7. Unique Identifier : AIDSLINE MED/99036786; Lari N; Cavallini M; Rindi L; Iona E; Fattorini L; Garzelli C; Dipartimento di Patologia Sperimentale, Biotecnologie Mediche,; Infettivologia ed Epidemiologia, Universita di Pisa, I-56127; Pisa, Italy.; All but 2 of 63 Mycobacterium avium isolates from distinct geographic areas of Italy exhibited markedly polymorphic, multibanded IS1245 restriction fragment length polymorphism (RFLP) patterns; 2 isolates showed the low-number banding pattern typical of bird isolates. By computer an
Isolation of blood-borne Mycobacterium avium by using the nonradioactive BACTEC 9000 MB system and comparison with a solid-culture system.: J Clin Microbiol. 1998 Dec;36(12):3703-6. Unique Identifier : AIDSLINE MED/99036788; Jacomo V; Musso D; Gevaudan MJ; Drancourt M; Laboratoire de Bacteriologie, Hygiene et Epidemiologie; Hospitaliere, Hopital Salvator, 13009 Marseille, France.; We conducted a 12-month prospective study comparing two approaches to the detection of Mycobacterium avium in the blood of human immunodeficiency virus type 1-infected patients, namely, a lytic centrifugation system combined with Middlebrook solid culture medium (the conventional procedure) and the nonradiometric BACT
Bystander suppression of experimental autoimmune encephalomyelitis by T cell lines and clones of the Th2 type induced by copolymer 1.: J Neuroimmunol. 1998 Nov 2;91(1-2):135-46. Unique Identifier : AIDSLINE MED/99061287; Aharoni R; Teitelbaum D; Sela M; Arnon R; Department of Immunology, The Weizmann Institute of Science,; Rehovot, Israel.; The synthetic amino acid copolymer, copolymer 1 (Cop 1) induces T suppressor (Ts) lines/clones, which are confined to the Th2 pathway, cross react with myelin basic protein (MBP), but not with other myelin antigens on the level of Th2 cytokine secretion. Nevertheless, Cop 1 Ts cells inhibited the
CD4+ T cell repertoire on the epsilon subunit of muscle acetylcholine receptor in myasthenia gravis.: J Neuroimmunol. 1998 Nov 2;91(1-2):33-42. Unique Identifier : AIDSLINE MED/99061274; Wang ZY; Okita DK; Howard JF Jr; Conti-Fine BM; Department of Biochemistry, University of Minnesota, Twin Cities,; St. Paul 55108-1022, USA.; We have identified sequence regions of the human muscle acetylcholine receptor epsilon subunit recognized by CD4+ T cells from myasthenia gravis patients. We tested the proliferative response in vitro of blood CD4+ cells from 18 myasthenic patients and 5 controls, to individual overlapping synthetic peptides spanning
Immunomodulatory effects of interferon-beta-1b in vivo: induction of the expression of transforming growth factor-beta1 and its receptor type II.: J Neuroimmunol. 1998 Nov 2;91(1-2):73-81. Unique Identifier : AIDSLINE MED/99061278; Ossege LM; Sindern E; Patzold T; Malin JP; Institute of Neurology, Ruhr-University of Bochum, BG Klinikum; Bergmannsheil, Germany.; The mechanisms by which interferon-beta-1b (IFNbeta-1b) acts in the treatment of patients with multiple sclerosis (MS) are not completely known. A total of 10 MS patients were treated with 8 million units of IFNbeta-1b every other day. Compared to baseline and control group the expression of TGFbeta-1-mRNA by PBMC was
Development of HIV encephalitis in AIDS and TNF-alpha regulatory elements.: J Neuroimmunol. 1998 Nov 2;91(1-2):89-92. Unique Identifier : AIDSLINE MED/99061280; Sato-Matsumura KC; Berger J; Hainfellner JA; Mazal P; Budka H; Institute of Neurology, University of Vienna, Austria.; Tumor necrosis factor-alpha (TNF-alpha) appears to play an important role in HIV encephalitis (HIVE). TNF2, a polymorphism of TNF-alpha, associates with higher levels of TNF-alpha and severe manifestations of some infections. We studied 44 acquired immunodeficiency syndrome (AIDS) patients with autopsy-proven HIVE and
What immunity can protect against HIV infection [editorial; comment]: J Clin Invest. 1998 Nov 1;102(9):1643-4. Unique Identifier : AIDSLINE MED/99021662; Letvin NL
GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice.: J Clin Invest. 1998 Nov 1;102(9):1704-14. Unique Identifier : AIDSLINE MED/99021669; Stampfli MR; Wiley RE; Neigh GS; Gajewska BU; Lei XF; Snider DP; Xing Z; Jordana M; Department of Pathology and Molecular Medicine, Immunology and; Infection Programme, and Centre for Gene Therapeutics, McMaster; University, Hamilton, Ontario, Canada L8N 3Z5.; The purpose of this study was to explore whether repeated exposure to aerosolized ovalbumin (OVA) in the context of local expression of GM-CSF can initiate a Th2-driven, eosinophilic inflammation in the airways. On day -1, Balb/c mice were infected intranasally with an adenovirus construct expressing GM-CSF (Ad/GM-CSF
Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi [see comments]: J Clin Invest. 1998 Nov 1;102(9):1758-65. Unique Identifier : AIDSLINE MED/99021675; Rowland-Jones SL; Dong T; Fowke KR; Kimani J; Krausa P; Newell H; Blanchard T; Ariyoshi K; Oyugi J; Ngugi E; Bwayo J; MacDonald KS; McMichael AJ; Plummer FA; Molecular Immunology Group, Institute of Molecular Medicine, John; Radcliffe Hospital, Oxford OX3 9DS, UK.; sarah.rowland-jones@ndm.ox.ac.uk; Many people who remain persistently seronegative despite frequent HIV exposure have HIV-specific immune responses. The study of these may provide information about mechanisms of natural protective immunity to HIV-1. We describe the specificity of cytotoxic T lymphocyte responses to HIV in seronegative prostitutes in N
Low stimulation of peripheral lymphocytes, following in vitro application of Emdogain.: J Clin Periodontol. 1998 Sep;25(9):715-20. Unique Identifier : AIDSLINE MED/98434290; Petinaki E; Nikolopoulos S; Castanas E; Laboratory of Clinical Immunology, University of Crete, School of; Medicine and University Hospital, Heraklion, Greece.; Fast tissue regeneration after therapeutic manipulations is a central problem of periodontology, oral surgery and trauma of the periodontal tissues, including bone. Several products, which augment tissue regeneration, have been manufactured and assayed in clinical practice with positive results. Emdogain is a recent a
Early-stage HIV infection and hepatitis C virus infection are associated with elevated serum porphyrin levels.: J Am Acad Dermatol. 1998 Dec;39(6):956-9. Unique Identifier : AIDSLINE MED/99057142; Lim HW; Pereira A; Sassa S; Kim M; Zolla-Pazner S; Department of Dermatology, Henry Ford Hospital, Detroit, MI; 48202-2689, USA.; BACKGROUND: Porphyria cutanea tarda is known to be associated with HIV infection and hepatitis C virus (HCV). OBJECTIVE: Our purpose was to evaluate whether early infection with HIV, with or without HCV infection, is associated with elevated serum porphyrin levels. METHODS: Serum porphyrin levels were measured in samp
Saliva collection technique for cytologic, microbiologic and viral evaluation in pediatric HIV infection.: ASDC J Dent Child. 1998 Sep-Oct;65(5):318-24, 355. Unique Identifier : AIDSLINE MED/99011827; Flaitz CM; Hicks MJ; Carter AB; Rossmann SN; Demmler GJ; Simon CL; Cron SG; Shearer WT; Kline MW; Department of Stomatology, University of Texas-Houston Health; Science Center, USA.; Acquisition of saliva for biologic, immunologic and chemical analyses has been extremely difficult in infants and young children due to lack of cooperation and motor skills necessary for expectorating adequately. The purpose of this study was to investigate a technique for obtaining satisfactory quantities of whole, u
Peripheral T-cell activation in non-segmental vitiligo.: J Dermatol. 1998 Oct;25(10):637-40. Unique Identifier : AIDSLINE MED/99047953; Mahmoud F; Abul H; al-Saleh Q; Haines D; Burleson J; Morgan G; Department of Medical Laboratory Sciences, Faculty of Allied; Health Sciences and Nursing, Kuwait University, Kuwait.; Vitiligo is a hypopigmentary dermatosis of probable autoimmune origin. Previously reported aberrations in peripheral blood mononuclear cells (PBMC), especially T cells and T cell subsets, have been inconsistent. Lymphocyte subpopulations were examined using flow cytometry and monoclonal antibodies against CD4, CD8, CD
Validation of the quality of life scale: living with HIV.: J Adv Nurs. 1998 Sep;28(3):622-30. Unique Identifier : AIDSLINE MED/98427663; Holzemer WL; Gygax Spicer J; Skodol Wilson H; Kemppainen JK; Coleman C; Department of Community Health Systems, University of California,; San Francisco 94143, USA.; A grounded theory of Salvaging Quality of Life provided the conceptual framework for the development of the Living with HIV scale which was validated in this study. The HIV + convenience sample (n = 187) was 66% male, with a mean age of 40.6 years, 69% African-American, and with an average CD4 count of 229 mm3. A prin
Healthier, wealthier and wiser [editorial]: J Am Dent Assoc. 1998 Dec;129(12):1660, 1662. Unique Identifier : AIDSLINE MED/99072071; Meskin LH
Prevalence of congenital cardiovascular malformations in children of human immunodeficiency virus-infected women: the prospective P2C2 HIV Multicenter Study. P2C2 HIV Study Group, National Heart, Lung, and Blood Institute, Bethesda, Maryland.: J Am Coll Cardiol. 1998 Nov 15;32(6):1749-55. Unique Identifier : AIDSLINE MED/99037899; Lai WW; Lipshultz SE; Easley KA; Starc TJ; Drant SE; Bricker JT; Colan SD; Moodie DS; Sopko G; Kaplan S; Department of Pediatrics, Mount Sinai School of Medicine, New; York, New York, USA. Wyman_Lai@smtplink.mssm.edu; OBJECTIVES: The purpose of the study was to assess the effects of maternal HIV-1 (human immunodeficiency virus) infection and vertically transmitted HIV-1 infection on the prevalence of congenital cardiovascular malformations in children. BACKGROUND: In the United States , an estimated
BCG infection suppresses allergic sensitization and development of increased airway reactivity in an animal model.: J Allergy Clin Immunol. 1998 Nov;102(5):867-74. Unique Identifier : AIDSLINE MED/99036725; Herz U; Gerhold K; Gruber C; Braun A; Wahn U; Renz H; Paul K; Departments of Laboratory Medicine and Pathobiochemistry and; Pediatric Pulmonology and Immunology, Charite, Campus; Virchow-Clinic, Berlin, Germany.; BACKGROUND: Epidemiologic studies suggest an inverse correlation between infections and development of atopy. The purpose of this study was to test the hypothesis whether a preexisting Th1-type immune response elicited by BCG immunization could suppress allergic sensitization and airway hyperreactivity in an animal mo
Nelfinavir-induced urticaria and successful desensitization.: J Allergy Clin Immunol. 1998 Nov;102(5):875-6. Unique Identifier : AIDSLINE MED/99036726; Demoly P; Messaad D; Trylesinski A; Faucherre V; Fabre J; Reynes J; Delmas C; Dohin E; Godard P; Bousquet J; Centre Hospitalier Universitaire, Maladies Respiratoires,; Hopital Arnaud de Villeneuve, Montpellier Cedex 5, France.
Clinical diorama [published erratum appears in J Am Optom Assoc 1998 Nov;69(11):687]: J Am Optom Assoc. 1998 Oct;69(10):676-7. Unique Identifier : AIDSLINE MED/99022291; Myers KJ; Outpatient Clinic, Grand Rapids, Michigan 49505, USA.
Type 2 diabetes in association with HIV-1 protease inhibitors in HIV-infected patients [editorial]: J Am Optom Assoc. 1998 Nov;69(11):695-8. Unique Identifier : AIDSLINE MED/99060311; Chronister CL; Gurwood AS
Prevalence and epidemiologic characteristics of opportunistic and non-opportunistic intestinal parasitic infections in HIV positive patients in Manipur.: J Commun Dis. 1998 Mar;30(1):19-22. Unique Identifier : AIDSLINE MED/99058300; Anand L; Dhanachand C; Brajachand N; Department of Life Sciences, Manipur University, Canchipur,; India.; A survey of the intestinal parasites among the HIV positive asymptomatic injecting drug users (IDUs) in Manipur State in North-east India revealed the presence of three protozoan and two nematode species. Of these, the two opportunistic parasitic protozoans i.e., Cryptosporidium sp.
Seroepidemiology of HIV, HBV, HCV and treponemal infections.: J Commun Dis. 1998 Mar;30(1):29-31. Unique Identifier : AIDSLINE MED/99058302; Kaur H; Marshalla R; Department of Microbiology, Christian Medical College, Ludhiana.; Sexually transmitted diseases are endemic in all societies and the prevalence of diseases spread by sex continues to increase. 233 serum samples submitted for VDRL test were screened for human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus by third generation Enzyme linked immunosorbent as
Some AIDS-related policy issues and nursing students' willingness to provide AIDS care.: J Commun Dis. 1998 Mar;30(1):38-43. Unique Identifier : AIDSLINE MED/99058304; Lal P; Kumar A; Ingle GK; Gulati N; Department of Preventive & Social Medicine, Maulana Azad Medical; College, New Delhi.; Two thirty three diploma students from a Nursing School, in Delhi were surveyed anonymously to seek their opinion on some AIDS-related policy issues and willingness to provide AIDS care. More than one fourth of students opinionated that health personnel should be given a choice to refuse care to the AIDS patients and
A clinical and virological study of hepatitis C virus-related cryoglobulinemia in Germany.: J Hepatol. 1998 Sep;29(3):375-84. Unique Identifier : AIDSLINE MED/98436012; Weiner SM; Berg T; Berthold H; Weber S; Peters T; Blum HE; Hopf U; Peter HH; Division of Rheumatology and Clinical Immunology, University; Hospital of Freiburg, Germany.; BACKGROUND/AIMS: Several reports, especially from Southern Europe, have demonstrated a close association between hepatitis C virus (HCV) infection and mixed cryoglobulinemia. In this study we have analyzed the significance of HCV-related cryoglobulinemia in Germany . METHODS: Sera
Clinical impact of lamivudine resistance in chronic hepatitis B [letter]: J Hepatol. 1998 Sep;29(3):510-1. Unique Identifier : AIDSLINE MED/98436033; Honkoop P; de Man RA; Niesters HG; Schalm SW
Nosocomial transmission of a drug-sensitive W-variant Mycobacterium tuberculosis strain among patients with acquired immunodeficiency syndrome in Tennessee [see comments]: Infect Control Hosp Epidemiol. 1998 Sep;19(9):635-9. Unique Identifier : AIDSLINE MED/98449608; Haas DW; Milton S; Kreiswirth BN; Brinsko VL; Bifani PJ; Schaffner W; Department of Medicine, Vanderbilt University Medical Center,; Nashville, TN, USA.; OBJECTIVE: To use DNA fingerprinting to characterize nosocomial spread of Mycobacterium tuberculosis following hospitalization of a patient with acquired immunodeficiency syndrome and active pulmonary tuberculosis, for whom respiratory isolation was not initiated promptly. DESIGN: Epidemiological investigation. SETTIN
Mycobacteria as pathogens of respiratory infection.: Infect Dis Clin North Am. 1998 Sep;12(3):593-611. Unique Identifier : AIDSLINE MED/98452416; Griffith DE; Center for Pulmonary Infectious Disease Control, University of; Texas Health Center, Tyler, USA.; As the result of a formidable effort, the recent TB epidemic in the United States has abated; however, major questions remain as the risk of TB diminishes. Will we maintain an adequate public health effort not only to prevent another resurgence of TB but also to renew our pursuit of TB
Pneumonia in the patient with HIV infection.: Infect Dis Clin North Am. 1998 Sep;12(3):807-20, xi. Unique Identifier : AIDSLINE MED/98452427; Bartlett JG; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland, USA.; The lower respiratory tract has always been a major site of complications in patients with human immunodeficiency virus (HIV) infection. In the era before Pneumocystis carinii prophylaxis (PCP) this organism accounted for more than 70% of initial AIDS-defining diagnoses and was by far the most common identifiable caus
Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells.: J Immunol. 1998 Nov 15;161(10):5111-5. Unique Identifier : AIDSLINE MED/99036362; D'Ambrosio D; Iellem A; Bonecchi R; Mazzeo D; Sozzani S; Mantovani A; Sinigaglia F; Roche Milano Ricerche, Milan, Italy. daniele.dambrosio@roche.com; Polarized Th1 and Th2 cells differentially express adhesion molecules and chemokine receptors, endowing these cells with distinct tissue homing capabilities. Here we report that, in contrast to other chemokine receptors, the expression of CCR4 and CCR8 on Th2 cells is transiently increased following TCR and CD28 engag
Passive but not active CD8+ T cell-based immunotherapy interferes with liver tumor progression in a transgenic mouse model.: J Immunol. 1998 Nov 15;161(10):5133-7. Unique Identifier : AIDSLINE MED/99036367; Romieu R; Baratin M; Kayibanda M; Lacabanne V; Ziol M; Guillet JG; Viguier M; Laboratoire des Pathologies Infectieuses et Tumorales, Institut; National de la Sante et de la Recherche Medicale U445, Paris,; France. romieu@cochin.inserm.fr; To evaluate tumor immunotherapies, we used transgenic mice that harbor a progressive liver tumor associated with the expression of the SV40 large tumor T oncoprotein (SV40-T). To induce self tumor Ag-specific CD8+ T cells, mice were injected with an immunodominant SV40-T CTL epitope mixed with a heterologous helper
LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production.: J Immunol. 1998 Nov 15;161(10):5138-42. Unique Identifier : AIDSLINE MED/99036368; Salomon B; Bluestone JA; Department of Pathology, Ben May Institute for Cancer Research,; University of Chicago, IL 60637, USA.; The role of CD28/B7 and LFA-1/ICAM costimulation in proliferation and Th1/Th2 differentiation of naive CD4+ T cells was addressed using T cells from DO11.10 TCR transgenic mice stimulated by dendritic cells. The blockade of either CD28/B7 or LFA-1/ICAM interactions partially inhibited T cell proliferation. By comparis
Selective induction of CD8+ cytotoxic T lymphocyte effector function by staphylococcus enterotoxin B.: J Immunol. 1998 Nov 15;161(10):5179-86. Unique Identifier : AIDSLINE MED/99036374; Fuller CL; Braciale VL; Department of Microbiology, Beirne B. Carter Center for; Immunology Research, Health Sciences Center, University of; Virginia, Charlottesville 22908, USA.; Upon encounter with its antigenic stimulus, CTL characteristically proliferate, produce cytokines, and lyse the Ag-presenting cell in an attempt to impede further infection. Superantigens are extremely efficient immunostimulatory proteins that promote high levels of proliferation and massive cytokine production in rea
Requirements for stimulating naive CD8+ T cells via signal 1 alone.: J Immunol. 1998 Nov 15;161(10):5226-35. Unique Identifier : AIDSLINE MED/99036380; Luxembourg AT; Brunmark A; Kong Y; Jackson MR; Peterson PA; Sprent J; Cai Z; R.W. Johnson Pharmaceutical Research Institute, San Diego, CA; 92121, USA.; In the absence of costimulation, TCR recognition of peptide/MHC complexes is generally considered to be nonimmunogenic. In agreement with this view, naive TCR transgenic CD8+ cells failed to respond to specific peptides presented by MHC class I (Ld) molecules bound to mouse RBC. However, peptide/Ld complexes presented
Type 2 immune deviation has differential effects on alloreactive CD4+ and CD8+ T cells.: Unique Identifier : AIDSLINE MED/99036381; Matesic D; Valujskikh A; Pearlman E; Higgins AW; Gilliam AC; Heeger PS; Allograft rejection has been associated with detection of the type 1 lymphokines, IFN-gamma and IL-2 . The role of type 2 cytokines (IL-4 and IL-5) remains controversial, as is whether alloreactive CD4+ and CD8+ T cells behave similarly when exposed to type 2 cytokine-e
Tolerant CD8 T cells induced by multiple injections of peptide antigen show impaired TCR signaling and altered proliferative responses in vitro and in vivo.: J Immunol. 1998 Nov 15;161(10):5260-7. Unique Identifier : AIDSLINE MED/99036384; Dubois PM; Pihlgren M; Tomkowiak M; Van Mechelen M; Marvel J; Immunologie Cellulaire, Laboratoire de Biologie Moleculaire et; Cellulaire, Ecole Normale Superieure de Lyon Centre National de; la Recherche Scientifique, France. patrice.dubois@ens-lyon.fr; The mechanisms responsible for peripheral CD8 T cell tolerance to foreign Ags remain poorly understood. In this study we have characterized the state of CD8 T cell tolerance induced in F5 TCR transgenic mice by multiple peptide injections in vivo. The tolerant state of CD8 T cells is characterized by impaired prolifer
B7.1 is a quantitatively stronger costimulus than B7.2 in the activation of naive CD8+ TCR-transgenic T cells.: J Immunol. 1998 Nov 15;161(10):5268-75. Unique Identifier : AIDSLINE MED/99036385; Fields PE; Finch RJ; Gray GS; Zollner R; Thomas JL; Sturmhoefel K; Lee K; Wolf S; Gajewski TF; Fitch FW; Department of Pathology, University of Chicago, IL 60637, USA.; Using a TCR transgenic mouse bred onto a recombinase-activating gene-2-deficient background, we have examined the influence of B7.1 and B7.2 on activation of naive, CD8+ T cells in vitro. We found that B7.1 was a more potent costimulus than B7.2 for induction of proliferation and
Oral tolerance to low dose beta 2-glycoprotein I: immunomodulation of experimental antiphospholipid syndrome.: J Immunol. 1998 Nov 15;161(10):5303-12. Unique Identifier : AIDSLINE MED/99036389; Blank M; George J; Barak V; Tincani A; Koike T; Shoenfeld Y; Department of Medicine B, Sheba Medical Center, Tel-Hashomer,; Israel.; Oral tolerance was induced in BALB/c mice by feeding low dose beta2-glycoprotein I (beta2GPI). The beta2GPI-fed mice did not develop serologic and clinical markers of experimental antiphospholipid syndrome (APS) upon immunization with the autoantigen. The treated group was characterized by low titers of serum anti-bet
Apoptotic death of CD8+ T lymphocytes after immunization: induction of a suppressive population of Mac-1+/Gr-1+ cells.: Unique Identifier : AIDSLINE MED/99036390; Bronte V; Wang M; Overwijk WW; Surman DR; Pericle F; Rosenberg SA; Restifo NP; Following an infection or immunization, a primary CD8+ T cell response generally rises then falls rapidly before giving rise to a memory response. When we immunized mice with recombinant viral immunogens optimized to enhance the lytic capability of CD8+ T cells, we measured a profound depression in Ag-specific effec
Alterations in cytokine production following intraocular injection of soluble protein antigen: impairment in IFN-gamma and induction of TGF-beta and IL-4 production.: J Immunol. 1998 Nov 15;161(10):5382-90. Unique Identifier : AIDSLINE MED/99036398; Kosiewicz MM; Alard P; Streilein JW; Department of Internal Medicine, Beirne B. Carter Center for; Immunology Research, University of Virginia Health Sciences; Center, Charlottesville 22908, USA.; Immune deviation induced by intraocular injection of soluble protein Ag, referred to as anterior chamber-associated immune deviation (ACAID), is characterized by impairment of delayed hypersensitivity (DH). Two populations of splenic regulatory cells that impair the induction and expression phases of DH are involved i
Attenuation of inducible Th2 immunity with autoimmune disease progression.: Unique Identifier : AIDSLINE MED/99036400; Tian J; Kaufman DL; Department of Molecular and Medical Pharmacology, University of; California, Los Angeles 90095, USA.; Autoantigen-based immunotherapeutics have been shown to activate regulatory responses capable of inhibiting T cell-mediated autoimmune disease in animal models. However, their efficacy generally declines, as treatment occurs later in the disease process, and their mechanism of action is a matter of intense debate. Her
Regulation of hepatitis B virus mRNA expression in a hepatitis B surface antigen transgenic mouse model by IFN-gamma-secreting T cells after DNA-based immunization.: J Immunol. 1998 Nov 15;161(10):5564-70. Unique Identifier : AIDSLINE MED/99036419; Mancini M; Hadchouel M; Tiollais P; Michel ML; Unite de Recombinaison et Expression Genetique, Institut; National de la Sante et de la Recherche Medicale, U163, Paris,; France.; The immunotherapeutic effect of DNA-mediated immunization against chronic hepatitis B virus (HBV) infection has been evaluated in transgenic mice expressing the sequences that code for the envelope proteins of HBV in the liver. In this model of HBV chronic carriers, a single i.m. injection of plasmid DNA encoding HBV
Phlebotomus papatasi sand fly salivary gland lysate down-regulates a Th1, but up-regulates a Th2, response in mice infected with Leishmania major.: J Immunol. 1998 Nov 15;161(10):5571-7. Unique Identifier : AIDSLINE MED/99036420; Mbow ML; Bleyenberg JA; Hall LR; Titus RG; Department of Pathology, Colorado State University College of; Veterinary Medicine and Biomedical Sciences, Fort Collins; 80523-1671, USA.; A vertebrate host becomes infected with Leishmania major when the sand fly vector injects parasites into skin along with saliva. Previous studies showed that salivary gland lysate of the New World sand fly Lutzomyia longipalpis markedly enhanced L. major infection in CBA mice. However, L. major is an Old World parasit
Regulation of T lymphocyte trafficking into lymph nodes during an immune response by the chemokines macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta.: J Immunol. 1998 Nov 15;161(10):5663-72. Unique Identifier : AIDSLINE MED/99036433; Tedla N; Wang HW; McNeil HP; Di Girolamo N; Hampartzoumian T; Wakefield D; Lloyd A; Inflammation Research Unit, School of Pathology, University of; New South Wales, Sydney, Australia.; By virtue of their target cell specificity, chemokines have the potential to selectively recruit leukocyte subpopulations into sites of inflammation. Their role in regulation of T lymphocyte traffic into lymph nodes during the development of an immune response has not previously been explored. The sensitization phase
Human complement component C1q inhibits the infectivity of cell-free HTLV-I.: J Immunol. 1998 Nov 15;161(10):5712-9. Unique Identifier : AIDSLINE MED/99036439; Ikeda F; Haraguchi Y; Jinno A; Iino Y; Morishita Y; Shiraki H; Hoshino H; Second Department of Surgery, Gunma University School of; Medicine, Maebashi, Japan.; Human T cell leukemia virus type I (HTLV-I) is a retrovirus that is not lysed by human serum or complement. It has not been determined, however, whether HTLV-I directly binds to complement components or whether it retains infectivity after incubation with human serum. We investigated the effects of human serum on the
Linked suppression of skin graft rejection can operate through indirect recognition.: J Immunol. 1998 Dec 1;161(11):5813-6. Unique Identifier : AIDSLINE MED/99049803; Wise MP; Bemelman F; Cobbold SP; Waldmann H; Dunn School of Pathology, Oxford, United Kingdom.; Adult mice can be rendered immunologically tolerant of allogeneic tissues if transplanted under cover of mAbs to CD4 and CD8. Tolerance generated in this manner is characterized by the presence of regulatory CD4+ T cells that can recruit naive T cells to become tolerant also through infectious tolerance. Regulatory
Differentiation of human NK cells into NK1 and NK2 subsets.: J Immunol. 1998 Dec 1;161(11):5821-4. Unique Identifier : AIDSLINE MED/99049805; Peritt D; Robertson S; Gri G; Showe L; Aste-Amezaga M; Trinchieri G; Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104,; USA.; Human NK cells cultured in the presence of IL-12 or IL-4 differentiate into cell populations with distinct patterns of cytokine secretion similar to Th1 and Th2 cells. NK cells grown in IL-12 (NK1) produce IL-10 and IFN-gamma, whereas NK cells grown in IL-4 (NK2) produce IL-5 and IL-13. Although these NK cell subsets
Oral administration of the bacterial superantigen staphylococcal enterotoxin B induces activation and cytokine production by T cells in murine gut-associated lymphoid tissue.: J Immunol. 1998 Dec 1;161(11):5825-31. Unique Identifier : AIDSLINE MED/99049806; Spiekermann GM; Nagler-Anderson C; Mucosal Immunology Laboratory, Massachusetts General Hospital,; Harvard Medical School, Charlestown 02129, USA.; The toxicity of the staphylococcal enterotoxins (SEs) has been linked to the activation of large numbers of T cells in the peripheral lymphoid tissues. Because the primary manifestations of foodborne enterotoxic poisoning are associated with the gastrointestinal tract, we have compared the responses of T cells in the
Nasal immunization of nonhuman primates with simian immunodeficiency virus p55gag and cholera toxin adjuvant induces Th1/Th2 help for virus-specific immune responses in reproductive tissues.: J Immunol. 1998 Dec 1;161(11):5952-8. Unique Identifier : AIDSLINE MED/99049822; Imaoka K; Miller CJ; Kubota M; McChesney MB; Lohman B; Yamamoto M; Fujihashi K; Someya K; Honda M; McGhee JR; Kiyono H; Immunobiology Vaccine Center, Department of Oral Biology,; University of Alabama, Birmingham 35294, USA.; Female rhesus macaques were nasally immunized with p55gag (p55) of SIV and cholera toxin as a mucosal adjuvant. Nasal immunization induced Ag-specific IgA and IgG Abs in mucosal secretions (e.g., cervicovaginal secretions, rectal washes, and saliva) and serum. Furthermore, high numbers of p55-specific IgA and IgG Ab-f
Regulation of the activity of IFN-gamma promoter elements during Th cell differentiation.: J Immunol. 1998 Dec 1;161(11):6105-12. Unique Identifier : AIDSLINE MED/99049840; Zhang F; Wang DZ; Boothby M; Penix L; Flavell RA; Aune TM; Department of Medicine, Vanderbilt University School of Medicine,; Nashville, TN 37232, USA.; Before they can deliver their effector functions, CD4+ Th cells must differentiate into Th1 or Th2 subsets. We have prepared reporter transgenic mice that express the luciferase gene under the control of proximal (prox.IFN-gamma) and distal (dist.IFN-gamma) regulatory elements from the IFN-gamma promoter to permit inv
The IL-4 rapidly produced in BALB/c mice after infection with Leishmania major down-regulates IL-12 receptor beta 2-chain expression on CD4+ T cells resulting in a state of unresponsiveness to IL-12.: J Immunol. 1998 Dec 1;161(11):6156-63. Unique Identifier : AIDSLINE MED/99049847; Himmelrich H; Parra-Lopez C; Tacchini-Cottier F; Louis JA; Launois P; World Health Organization Immunology Research and Training; Center, Institute of Biochemistry, University of Lausanne,; Epalinges, Switzerland.; Within 1 day of infection with Leishmania major, susceptible BALB/c mice produce a burst of IL-4 in their draining lymph nodes, resulting in a state of unresponsiveness to IL-12 in parasite-specific CD4+ T cells within 48 h. In this report we examined the molecular mechanism underlying this IL-12 unresponsiveness. Ext
FLT3-ligand administration inhibits liver metastases: role of NK cells.: J Immunol. 1998 Dec 1;161(11):6164-70. Unique Identifier : AIDSLINE MED/99049848; Peron JM; Esche C; Subbotin VM; Maliszewski C; Lotze MT; Shurin MR; Biologic Therapeutics Program, University of Pittsburgh Cancer; Institute, PA 15213, USA.; FLT3-ligand (FL) is a recently described cytokine that stimulates the proliferation and differentiation of hematopoietic progenitors both in vivo and in vitro and, when administered to mice, induces an accumulation of dendritic cells (DC) in different lymphoid and nonlymphoid organs and tissues, including the liver. W
LeIF: a recombinant Leishmania protein that induces an IL-12-mediated Th1 cytokine profile.: J Immunol. 1998 Dec 1;161(11):6171-9. Unique Identifier : AIDSLINE MED/99049849; Skeiky YA; Kennedy M; Kaufman D; Borges MM; Guderian JA; Scholler JK; Ovendale PJ; Picha KS; Morrissey PJ; Grabstein KH; Campos-Neto A; Reed SG; Corixa Corporation, Seattle, WA 98104, USA. Skeiky@Corixa.Com; We have evaluated the ability of the Leishmania protein LeIF to influence the Th1/Th2 cytokine responses and the generation of LeIF-specific T cell clones in the absence of adjuvant. We characterized LeIF-specific T cell responses in Leishmania major-infected and uninfected BALB/c mice. These mice develop a strong Th2
Mice with STAT6-targeted gene disruption develop a Th1 response and control cutaneous leishmaniasis.: J Immunol. 1998 Dec 1;161(11):6180-8. Unique Identifier : AIDSLINE MED/99049850; Stamm LM; Raisanen-Sokolowski A; Okano M; Russell ME; David JR; Satoskar AR; Department of Immunology and Infectious Diseases, Harvard School; of Public Health, Boston, MA 02115, USA.; The cutaneous growth of Leishmania mexicana was measured in STAT6-deficient mice (STAT6-/-) and compared with that in similarly infected wild-type (STAT6+/+) mice. Following s.c. inoculation with 5 x 10(6) amastigotes of L. mexicana into the shaven rump, STAT6+/+ mice developed large, nonhealing cutaneous lesions, whi
Host genetic determinants of vaccine-induced eosinophilia during respiratory syncytial virus infection.: Unique Identifier : AIDSLINE MED/99049854; Hussell T; Georgiou A; Sparer TE; Matthews S; Pala P; Openshaw PJ; In BALB/c mice, sensitization with the attachment protein (G) of respiratory syncytial virus (RSV) leads to CD4+ T cell-mediated lung eosinophilia during subsequent challenge with RSV. To determine the host genetic influences on this model of lung eosinophilia, we tested 15 different inbred mouse strains. Eosinophilia
Differential effects of CD28 costimulation on HIV production by CD4+ cells.: J Immunol. 1998 Dec 1;161(11):6223-7. Unique Identifier : AIDSLINE MED/99049855; Barker E; Bossart KN; Levy JA; Department of Medicine, University of California, San Francisco; 94143-1270, USA.; We have observed that CD28 costimulation of CD4+ cells can have differential effects on HIV replication. Triggering the CD28 molecule on peripheral blood CD4+ cells during stimulation with anti-CD3 Abs enhances virus production following acute infection with HIV. Endogenous virus production in CD4+ cells from HIV-infe
IL-10 is required for development of protective Th1 responses in IL-12-deficient mice upon Candida albicans infection.: J Immunol. 1998 Dec 1;161(11):6228-37. Unique Identifier : AIDSLINE MED/99049856; Mencacci A; Cenci E; Del Sero G; Fe d'Ostiani C; Mosci P; Trinchieri G; Adorini L; Romani L; Department of Experimental Medicine and Biochemical Sciences,; University of Perugia, Italy.; IL-12 is both required and prognostic for Th1 development in mice with Candida albicans infection. To delineate further the physiologic role of IL-12 in antifungal immunity, mice deficient for this cytokine were assessed for susceptibility to C. albicans infections, and for parameters of innate and adaptive immunity.
Neutralizing antibodies to IFN-gamma-inducing factor prevent experimental autoimmune encephalomyelitis.: J Immunol. 1998 Dec 1;161(11):6368-74. Unique Identifier : AIDSLINE MED/99049873; Wildbaum G; Youssef S; Grabie N; Karin N; Department of Immunology, Bruce Rappaport Faculty of Medicine,; Haifa, Israel.; Specific oligonucleotide primers were used to identify and isolate IFN-gamma-inducing factor (IGIF) from the brain of rats with developing experimental autoimmune encephalomyelitis (EAE), a T cell-mediated autoimmune disease of the central nervous system that serves as a model for multiple sclerosis. IGIF was highly t
The role of CD8+ CD40L+ T cells in the formation of germinal centers in rheumatoid synovitis.: J Immunol. 1998 Dec 1;161(11):6390-7. Unique Identifier : AIDSLINE MED/99049876; Wagner UG; Kurtin PJ; Wahner A; Brackertz M; Berry DJ; Goronzy JJ; Weyand CM; Department of Medicine, Mayo Clinic and Foundation, Rochester, MN; 55905, USA.; In rheumatoid synovitis, lymphocytes can be arranged in follicular structures resembling secondary lymphoid follicles. To understand the organizing principles of this ectopic lymphoid tissue, the cellular components contributing to synovial follicles were examined. In 9 of 24 synovial tissue biopsies, lymphoid aggrega
A novel factor produced by placental cells with activity against HIV-1.: J Immunol. 1998 Dec 1;161(11):6406-12. Unique Identifier : AIDSLINE MED/99049878; Sharma UK; Trujillo J; Song HF; Saitta FP; Laeyendecker OB; Castillo R; Arango-Jaramillo S; Sridharan G; Dettenhofer M; Blakemore K; Yu XF; Schwartz DH; Department of Molecular Microbiology and Immunology, School of; Hygiene and Public Health, Johns Hopkins University, Baltimore,; MD 21205, USA.; The factors controlling the dynamics of HIV-1 transmission from mother to infant are not clearly known. Previous studies have suggested the existence of maternal and placental protective mechanisms that inhibit viral replication in utero. Preliminary studies from our laboratory revealed that supernatant from placental
Natural killer cells from HIV-1+ patients produce C-C chemokines and inhibit HIV-1 infection.: J Immunol. 1998 Dec 1;161(11):6433-8. Unique Identifier : AIDSLINE MED/99049882; Fehniger TA; Herbein G; Yu H; Para MI; Bernstein ZP; O'Brien WA; Caligiuri MA; Department of Internal Medicine, Ohio State University, Columbus; 43210, USA.; Human NK cells have been shown to produce cytokines (e.g., IFN-gamma and TNF-alpha) and the chemokine macrophage inflammatory protein (MIP)-1alpha following stimulation with the combination of two monokines, IL-15 plus IL-12. The C-C chemokines MIP-1alpha, MIP-1beta, and RANTES have been identified as the major solubl
Monitoring of intracellular levels of 5'-monophosphate-AZT using an enzyme immunoassay.: J Immunol Methods. 1998 Sep 1;218(1-2):19-30. Unique Identifier : AIDSLINE MED/99034429; Goujon L; Brossette T; Dereudre-Bosquet N; Creminon C; Clayette P; Dormont D; Mioskowski C; Lebeau L; Grassi J; CEA, Departement de Recherche Medicale, CEA Saclay, Gif sur; Yvette, France.; We have developed a competitive enzyme immunoassay suitable for routine monitoring of intracellular levels of 5 -monophosphate- AZT (AZT-MP). This assay is performed in 96-well microtiter plates coated with anti-rabbit immunoglobulin antibodies and is
A new in vitro model for studying human T cell differentiation: T(H1)/T(H2) induction following activation by superantigens.: J Immunol Methods. 1998 Oct 1;219(1-2):85-98. Unique Identifier : AIDSLINE MED/99047285; Gehring S; Schlaak M; van der Bosch J; Division of Experimental Immunopharmacology, Research Center; Borstel, Germany. sgehring@fz-borstel.de; A new T(H1)/T(H2) in vitro model for mechanistic studies and drug screening in human T cells was established working with ficoll-separated PBMCs or elutriated lymphocytes cultured in serum-free medium. Human T cells could be kept viable and reactive in this medium for several months. In this model, superantigens (SAs)
Intranasal immunization with a plant virus expressing a peptide from HIV-1 gp41 stimulates better mucosal and systemic HIV-1-specific IgA and IgG than oral immunization.: J Immunol Methods. 1998 Nov 1;220(1-2):93-103. Unique Identifier : AIDSLINE MED/99053665; Durrani Z; McInerney TL; McLain L; Jones T; Bellaby T; Brennan FR; Dimmock NJ; Department of Biological Sciences, University of Warwick,; Coventry, UK.; Control of pandemic human immunodeficiency virus type 1 (HIV-1) infection ideally requires specific mucosal immunity to protect the genital regions through which transmission more often occurs. Thus a vaccine that stimulates a disseminated mucosal and systemic protective immune response would be extremely useful. Here
High risk donors and AIDS in transfusion practice [editorial]: J Indian Med Assoc. 1998 Jul;96(7):201, 204. Unique Identifier : AIDSLINE MED/99047977; Jolly JG
A retrospective study of treatment of cerebral toxoplasmosis in AIDS patients with trimethoprim-sulphamethoxazole.: J Infect. 1998 Jul;37(1):15-8. Unique Identifier : AIDSLINE MED/98402207; Torre D; Speranza F; Martegani R; Zeroli C; Banfi M; Airoldi M; Division of Infectious Diseases, Regional Hospital, Varese,; Italy.; AIMS OF THE STUDY: a retrospective study was designed to evaluate efficacy and tolerance of trimethoprim-sulphamethoxazole (TMP-SMZ) in AIDS patients with cerebral toxoplasmosis (TE). PATIENTS AND METHODS: we reviewed 471 patients with AIDS, and we analysed 71 AIDS patients with TE, who received intravenous therapy wi
A retrospective study on the efficacy and safety of amphotericin B in a lipid emulsion for the treatment of cryptococcal meningitis in AIDS patients.: J Infect. 1998 Jul;37(1):36-8. Unique Identifier : AIDSLINE MED/98402211; Torre D; Banfi G; Tambini R; Speranza F; Zeroli C; Martegani R; Airoldi M; Fiori G; Division of Infectious Diseases, Ospedali Riuniti, Bergamo,; Italy.; To evaluate the efficacy and safety of Amphotericin B dissolved in dextrose (Amb) or in a lipid emulsion (Intralipid, Amb-IL) in AIDS patients with cryptococcal meningitis, we conducted a retrospective study in 30 AIDS patients with cryptococcal meningitis. A clinical complete resolution was obtained in 11 patients (5
Chronic diarrhoea among HIV-infected adult patients in Nairobi, Kenya.: J Infect. 1998 Jul;37(1):48-53. Unique Identifier : AIDSLINE MED/98402215; Mwachari C; Batchelor BI; Paul J; Waiyaki PG; Gilks CF; Kenya Medical Research Institute, Nairobi.; OBJECTIVES: Chronic diarrhoea and wasting are well recognized features of AIDS in Africa. However, because of resource constraints few comprehensive aetiological studies have been conducted in sub-Saharan Africa which have included a broad range of microbiological investigations. We undertook a prospective cross-secti
Can alprostadil improve liver failure in HIV-infected patients with severe acute viral hepatitis?: J Infect. 1998 Jul;37(1):84-6. Unique Identifier : AIDSLINE MED/98402229; Reus S; Priego M; Boix V; Torrus D; Portilla J; Seccion de Enfermedades Infecciosas, Hospital General; Universitario de Alicante, Spain.; Liver failure with hepatic encephalopathy during an acute viral hepatitis carries a very high mortality. Liver transplantation is the usual treatment, but for poor candidates for transplantation only supportive therapy is available. Two patients with HIV infection developed an acute B hepatitis with liver insufficienc
Bilateral thrombosis of the internal jugular veins with spasmodic torticollis in a patient with acquired immunodeficiency syndrome and disseminated cytomegalovirus infection [letter]: J Infect. 1998 Jul;37(1):90-1. Unique Identifier : AIDSLINE MED/98402234; Vielhauer V; Schewe CK; Schlondorff D
Early diagnosis of primary human herpesvirus 6 infection in childhood: serology, polymerase chain reaction, and virus load.: J Infect Dis. 1998 Nov;178(5):1250-6. Unique Identifier : AIDSLINE MED/98453439; Chiu SS; Cheung CY; Tse CY; Peiris M; Department of Pediatrics and Microbiology, University of Hong; Kong.; Qualitative and quantitative polymerase chain reaction (PCR) for human herpesvirus 6 (HHV-6) DNA in whole blood and plasma was correlated with serology and clinical assessment in 143 children hospitalized for undifferentiated febrile illness to evaluate options for diagnosis of primary HHV-6 infection on the acute blo
Activation and cell cycle antigens in CD4+ and CD8+ T cells correlate with plasma human immunodeficiency virus (HIV-1) RNA level in HIV-1 infection.: J Infect Dis. 1998 Nov;178(5):1279-87. Unique Identifier : AIDSLINE MED/98453443; Orendi JM; Bloem AC; Borleffs JC; Wijnholds FJ; de Vos NM; Nottet HS; Visser MR; Snippe H; Verhoef J; Boucher CA; Department of Medical Microbiology, Leiden University Medical; Center, The Netherlands.; The relationship between T cell activation and human immunodeficiency virus type 1 (HIV-1) replication was studied in HIV-infected subjects, 20 with and 10 without anti-HIV treatment. Expression of Ki-67 proliferation-associated antigen was increased in CD4+ and CD8+ T cells and correlated with HLA-DR. In subjects wit
All-trans retinoic acid inhibition of anti-CD3-induced T cell apoptosis in human immunodeficiency virus infection mostly concerns CD4 T lymphocytes and is mediated via regulation of CD95 ligand expression.: J Infect Dis. 1998 Nov;178(5):1288-98. Unique Identifier : AIDSLINE MED/98453444; Szondy Z; Lecoeur H; Fesus L; Gougeon ML; Department of Biochemistry, University Medical School of Debreen,; Hungary.; This study analyzes the influence of all-trans retinoid acid (tRA) on apoptosis of peripheral lymphocytes from human immunodeficiency virus (HIV)-positive patients. tRA inhibits the ex vivo apoptosis in T cells; a more potent effect was observed on activation-induced apoptosis. Phenotypic characterization of T cell su
Highly active antiretroviral therapy normalizes the function of progenitor cells in human immunodeficiency virus-infected patients.: J Infect Dis. 1998 Nov;178(5):1299-305. Unique Identifier : AIDSLINE MED/98453445; Dam Nielsen S; Kjaer Ersboll A; Mathiesen L; Nielsen JO; Hansen JE; Department of Infectious Diseases, Hvidovre Hospital,; Frederiksberg, Denmark.; CD34 cells from human immunodeficiency virus (HIV)-infected persons have been described to be impaired in function. The effect of highly active antiretroviral treatment (HAART) on the function of CD34 cells in HIV-infected patients was examined. Numbers and function of CD34 cells from 11 HIV-infected patients were det
Correlation between humoral responses to human immunodeficiency virus type 1 envelope and disease progression in early-stage infection.: J Infect Dis. 1998 Nov;178(5):1306-16. Unique Identifier : AIDSLINE MED/98453446; Loomis-Price LD; Cox JH; Mascola JR; VanCott TC; Michael NL; Fouts TR; Redfield RR; Robb ML; Wahren B; Sheppard HW; Birx DL; H.M. Jackson Foundation, Walter Reed Army Institute of Research,; Rockville, MD, USA. lloomis-price@hiv.hif.org; Human immunodeficiency virus (HIV)-1-infected rapid and slow progressors showed differential humoral responses against HIV envelope peptides and proteins early in infection. Sera from slow progressors reacted more strongly with short envelope peptides modeling gp160NL4-3, predominantly in gp41. Reactivity to six pepti
Longitudinal and cross-sectional analysis of cytotoxic T lymphocyte responses and their relationship to vertical human immunodeficiency virus transmission. ARIEL Project Investigators.: J Infect Dis. 1998 Nov;178(5):1317-26. Unique Identifier : AIDSLINE MED/98453447; Jin X; Roberts CG; Nixon DF; Cao Y; Ho DD; Walker BD; Muldoon M; Korber BT; Koup RA; Aaron Diamond Aids Research Center, Rockfeller University, New; York, NY, USA.; The ARIEL Project for the Prevention of HIV Transmission from Mother to Infant was established to evaluate virologic and immunologic parameters during vertical transmission. To determine the strength and breadth of the cytotoxic T lymphocyte (CTL) response and its correlation with human immunodeficiency virus (HIV) tr
Pharmacokinetics and antiretroviral activity of lamivudine alone or when coadministered with zidovudine in human immunodeficiency virus type 1-infected pregnant women and their offspring.: J Infect Dis. 1998 Nov;178(5):1327-33. Unique Identifier : AIDSLINE MED/98453448; Moodley J; Moodley D; Pillay K; Coovadia H; Saba J; van Leeuwen R; Goodwin C; Harrigan PR; Moore KH; Stone C; Plumb R; Johnson MA; Department of Obstetrics and Paediatrics, University of Natal,; Durban, South Africa. moodleyj@med.und.ac.az@relay; The safety, pharmacokinetics, and antiretroviral activity of lamivudine alone and in combination with zidovudine was studied in pregnant women infected with human immunodeficiency virus type 1 (HIV-1) and their neonates. Women received the drugs orally from week 38 of pregnancy to 1 week after delivery. Neonate therap
Cervical human immunodeficiency virus type 1 shedding is associated with genital beta-chemokine secretion.: J Infect Dis. 1998 Nov;178(5):1334-42. Unique Identifier : AIDSLINE MED/98453449; Iversen AK; Fugger L; Eugen-Olsen J; Balslev U; Jensen T; Wahl S; Gerstoft J; Mullins JI; Skinhoj P; Department of Infectious Diseases, Rigshospitalet, National; University Hospital, Copenhagen, Denmark. aifrhm@inet.uni-2.dk; Forty human immunodeficiency virus type 1 (HIV-1)-infected women participated in a cross-sectional study of possible correlations between chemokine receptor (CCR5 and/or CCR2B) genotype, HIV-1 RNA and DNA load, and beta-chemokine levels (RANTES, MIP-1alpha, MIP-1beta) in blood and cervix. HIV-1 nucleic acid and beta-c
A human immunodeficiency virus (HIV)-inducing factor from the female genital tract activates HIV-1 gene expression through the kappaB enhancer.: Unique Identifier : AIDSLINE MED/98453450; Al-Harthi L; Spear GT; Hashemi FB; Landay A; Sha BE; Roebuck KA; Virus-enhancing factors present in the female genital tract may influence the transmission of human immunodeficiency virus type 1 (HIV-1). Previously, the presence of a heat-stable soluble factor in the cervicovaginal lavage (CVL) fluid of both HIV-infected and uninfected women that induces HIV-1 expression in T cells
Effect of human immunodeficiency virus type 1 infection upon acute salpingitis: a laparoscopic study.: J Infect Dis. 1998 Nov;178(5):1352-8. Unique Identifier : AIDSLINE MED/98453451; Cohen CR; Sinei S; Reilly M; Bukusi E; Eschenbach D; Holmes KK; Ndinya-Achola JO; Bwayo J; Grieco V; Stamm W; Karanja J; Kreiss J; Department of Obstetrics and Gynecology, University of; Washington, Seattle, USA. crohen@u.washington.edu; To determine the effect of human immunodeficiency virus type 1 (HIV-1) infection upon pelvic inflammatory disease (PID), a laparoscopic study of acute PID was conducted in Nairobi, Kenya . Subjects underwent diagnostic laparoscopy, HIV-1 serology, and testing for sexually transmitted
Chimeric influenza virus replicating predominantly in the murine upper respiratory tract induces local immune responses against human immunodeficiency virus type 1 in the genital tract.: J Infect Dis. 1998 Nov;178(5):1359-68. Unique Identifier : AIDSLINE MED/98453452; Ferko B; Katinger D; Grassauer A; Egorov A; Romanova J; Niebler B; Katinger H; Muster T; Institut fur Angewandte Mikrobiologie, Universitat fur; Bodenkultur, Vienna, Austria.; Previously, a mucosal model of immunization against human immunodeficiency virus type 1 (HIV-1) was established by using influenza virus as a vector for the neutralizing gp41 epitope ELDKWA. Whether replication of this chimeric influenza virus in the upper respiratory tract of mice is sufficient for inducing mucosal i
Successful treatment of diarrheal disease associated with enteroaggregative Escherichia coli in adults infected with human immunodeficiency virus.: J Infect Dis. 1998 Nov;178(5):1369-72. Unique Identifier : AIDSLINE MED/98453453; Wanke CA; Gerrior J; Blais V; Mayer H; Acheson D; Department of Medicine, Division of Infectious Diseases, Beth; Israel Deaconess Medical Center, New England, USA.; cwanke@infonet.tufts.edu; The presence of enteroaggregative Escherichia coli (EAggEC) in stool has been strongly associated with persistent diarrhea. No treatment trials have been done to demonstrate that clearance of EAggEc results in an improvement of diarrheal symptoms. Twenty-four adults infected with the human immunodeficiency virus (HIV)
Enhanced responses to Mycobacterium tuberculosis antigens by human alveolar lymphocytes during active pulmonary tuberculosis.: J Infect Dis. 1998 Nov;178(5):1434-45. Unique Identifier : AIDSLINE MED/98453461; Schwander SK; Torres M; Sada E; Carranza C; Ramos E; Tary-Lehmann M; Wallis RS; Sierra J; Rich EA; Department of Medicine, Case Western Reserve University,; Cleveland, Ohio, USA. sxs127@po.cwru.edu; Responses to mycobacterial and nonmycobacterial antigens were examined in bronchoalveolar cells (BAC) and peripheral blood mononuclear cells (PBMC) from patients with active pulmonary tuberculosis (n=16) and healthy subjects (n=23). DNA synthesis in BAC (but not PBMC) from tuberculosis patients was significantly incre
Eradication of AIDS-related disseminated mycobacterium avium complex infection after 12 months of antimycobacterial therapy combined with highly active antiretroviral therapy.: J Infect Dis. 1998 Nov;178(5):1446-9. Unique Identifier : AIDSLINE MED/98453462; Aberg JA; Yajko DM; Jacobson MA; Department of Medicine, University of California, San Francisco,; USA. jaberg@sfaids.ucsf.edu; To determine if microbiologic cure of AIDS-related disseminated Mycobacterium avium complex (MAC) is possible in patients receiving highly active antiretroviral therapy (HAART), 4 patients with a history of disseminated MAC received >/=12 months of macrolide-based antimycobacterial therapy. All were asymptomatic and h
Cryptococcus neoformans and Candida albicans regulate CD4 expression on human monocytes.: J Infect Dis. 1998 Nov;178(5):1464-71. Unique Identifier : AIDSLINE MED/98453465; Pietrella D; Monari C; Retini C; Palazzetti B; Kozel TR; Vecchiarelli A; Microbiology Section Department of Experimental Medicine,; University of Perugia, Italy.; This study examined the capability of Candida albicans and Cryptococcus neoformans to modulate CD4 expression on human monocytes. C. albicans and an acapsular strain of C. neoformans induced higher levels of CD4 expression than encapsulated strains. Purified glucuronoxylomannan did not regulate CD4 expression on monoc
Comparison of the prevalence of antibodies to human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) in Brazil and Colorado.: J Infect Dis. 1998 Nov;178(5):1488-91. Unique Identifier : AIDSLINE MED/98453468; Zhang Xq; Fitzpatrick L; Campbell TB; Badaro R; Schechter M; Melo Md; Brites C; Pedral-Sampaio D; Schooley RT; Division of Infectious Disease, Department of Medicine,; University of Colorado Health Sciences Center, Denver, USA.; The prevalence of human herpesvirus 8 (HHV-8; Kaposi s sarcoma [KS] herpesvirus) infection was determined by IFA in 297 persons living in Brazil and Colorado. The prevalence of antibody to HHV-8 in human immunodeficiency virus (HIV) type 1-seropositive gay men with and without KS w
Direct human papillomavirus (HPV) sequencing method yields a novel HPV in a human immunodeficiency virus-positive Quebec woman and distinguishes a new HPV clade.: J Infect Dis. 1998 Nov;178(5):1492-6. Unique Identifier : AIDSLINE GENBANK/AF042837; Feoli-Fonseca JC; Oligny LL; Filion M; Brochu P; Russo PA; Yotov WV; Department of Pathology, Research Center, University of Montreal,; Canada.; Papillomaviruses of supergroup A exhibit genital tropism and are best known as etiologic agents for benign and malignant cervical lesions in women. A polymerase chain reaction direct sequencing approach with P-33-labeled dideoxynucleotides was used to detect and type human papillomaviruses (HPVs) in cervical biopsies.
Resistance mutations in protease and reverse transcriptase genes of human immunodeficiency virus type 1 isolates from patients with combination antiretroviral therapy failure.: J Infect Dis. 1998 Nov;178(5):1497-501. Unique Identifier : AIDSLINE GENBANK/AF072974; Young B; Johnson S; Bahktiari M; Shugarts D; Young RK; Allen M; Ramey RR 2nd; Kuritzkes DR; Division of Infectious Diseases, University of Colorado Health; SciencesCenter, Boulder, USA. Ben.Young@UCHSC.edu; High-density oligonucleotide arrays were used to determine the sequence of the protease (PR) and reverse transcriptase (RT) genes of human immunodeficiency virus type 1 isolates from 35 patients in whom combination therapy that included a protease inhibitor had failed.
Neutralization of syncytium-inducing primary isolates by sera from human immunodeficiency virus (HIV)-uninfected recipients of candidate HIV vaccines.: J Infect Dis. 1998 Nov;178(5):1502-6. Unique Identifier : AIDSLINE MED/98453471; Zolla-Pazner S; Xu S; Burda S; Duliege AM; Excler JL; Clements-Mann ML; Department of Veterans Affairs Medical Center, New York, USA.; ZOLLAS01@MCRCR6.med.nyu.edu; Most candidate human immunodeficiency virus (HIV)-1 vaccines induce antibodies that neutralize T cell line-adapted HIV-1 strains. Until recently, however, no neutralizing activity against primary HIV-1 isolates had been demonstrated in sera from human vaccinees. Since most candidate HIV-1 vaccines have been constructe
Diversification of subtype E human immunodeficiency virus type 1 env in heterosexual seroconverters from Northern Thailand.: J Infect Dis. 1998 Nov;178(5):1507-11. Unique Identifier : AIDSLINE MED/98453472; Wang Z; Lyles CM; Beyrer C; Celentano DD; Vlahov D; Natpratan C; Markham R; Khamboonruang C; Nelson K; Yu XF; Department of Molecular Microbiology, Johns Hopkins University; School of Hygiene, Baltimore, USA.; The C2-V3 region of the human immunodeficiency virus (HIV)-1 env was determined from 15 northern Thailand seroconverters between 1993 and 1995. Similar sequences were also determined from 18 seroconverting injection drug users in Baltimore. All seroconverters from northern Thaila
Borrelia burgdorferi-infected, interleukin-6-deficient mice have decreased Th2 responses and increased lyme arthritis.: J Infect Dis. 1998 Nov;178(5):1512-5. Unique Identifier : AIDSLINE MED/98453473; Anguita J; Rincon M; Samanta S; Barthold SW; Flavell RA; Fikrig E; Section of Rheumatology, Department of Internal Medicine, Howard; Hughes Medical Institute, New Haven, Connecticut, USA.; Recently, interleukin (IL)-6 was shown to be one of the earliest factors that trigger the differentiation of naive T cells into effector Th2 cells in vitro. Lyme arthritis was studied in IL-6-deficient mice, since joint inflammation is influenced by the T helper cell response against Borrelia burgdorferi. Arthritis in
Neutrophils from AIDS patients treated with granulocyte colony-stimulating factor demonstrate enhanced killing of Mycobacterium avium.: J Infect Dis. 1998 Nov;178(5):1530-3. Unique Identifier : AIDSLINE MED/98453477; George S; Coffey M; Cinti S; Collins J; Brown M; Kazanjian P; Divisions of Infectious Diseases and Pulmonary Medicine,; University of Michigan Medical Center, Ann Arbor, USA.; Neutrophils isolated from AIDS patients have demonstrated improved growth inhibition of Mycobacterium avium when incubated with exogenous granulocyte colony-stimulating factor (G-CSF). In this clinical study, 30 AIDS patients without M. avium infection were randomized to receive 5 days of treatment with rifabutin, G-C
Polymerase chain reaction (PCR) from ficoll-purified polymorphonuclear leukocytes for monitoring cytomegalovirus infections in renal allograft recipients: superior sensitivity and similar specificity compared with plasma PCR [letter]: J Infect Dis. 1998 Nov;178(5):1544-6. Unique Identifier : AIDSLINE MED/98453480; Schafer P; Kuhn JE; Tenschert W; Eing B; Schroter M; Laufs R
Study of human herpesvirus 8 (HHV-8) variants from Kaposi's sarcoma in France: is HHV-8 subtype A responsible for more agressive tumors? [letter]: J Infect Dis. 1998 Nov;178(5):1546-7. Unique Identifier : AIDSLINE MED/98453482; Boralevi F; Masquelier B; Denayrolles M; Dupon M; Pellegrin JL; Ragnaud JM; Fleury HJ
[TH1/TH2 balance in chronic rheumatoid arthritis]: Nippon Naika Gakkai Zasshi. 1998 Aug 10;87(8):1595-600. Unique Identifier : AIDSLINE MED/98453977; Ishida H
Instillation of allogeneic lung macrophages and dendritic cells cause differential effects on local IFN-gamma production, lymphocytic bronchitis, and vasculitis in recipient murine lungs.: J Leukoc Biol. 1998 Nov;64(5):578-86. Unique Identifier : AIDSLINE MED/99039367; Wilkes DS; Thompson LK; Cummings OW; Bragg S; Heidler KM; Department of Medicine, Indiana University School of Medicine,; Indianapolis 46202, USA. dwilkes@mdep.iupui.edu; Lung allograft rejection is believed to be initiated by donor lung accessory cells, namely macrophages and dendritic cells, interacting with recipient lymphocytes leading to up-regulated Th1 type (IFN-gamma) cellular immunity culminating in graft destruction. The purpose of this study was to determine the individual r
IL-4 and a glucocorticoid up-regulate CXCR4 expression on human CD4+ T lymphocytes and enhance HIV-1 replication.: J Leukoc Biol. 1998 Nov;64(5):642-9. Unique Identifier : AIDSLINE MED/99039376; Wang J; Harada A; Matsushita S; Matsumi S; Zhang Y; Shioda T; Nagai Y; Matsushima K; Department of Molecular Preventive Medicine, School of Medicine; and CREST, University of Tokyo, Japan.; CXCR4 is a key co-receptor required for the infection of T-tropic HIV-1 strain of CD4+ T lymphocytes. The regulation of this chemokine receptor was therefore studied. Th2 polarized cells expressed more CXCR4 than Th1 cells. Among a panel of cytokines and stimulants, a Th2 type cytokine interleukin-4 (IL-4) selectively
Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development.: J Exp Med. 1998 Nov 2;188(9):1651-6. Unique Identifier : AIDSLINE MED/99021686; Wakil AE; Wang ZE; Ryan JC; Fowell DJ; Locksley RM; Department of Medicine and the Department of; Microbiology/Immunology, University of California San Francisco,; San Francisco, California 94143, USA.; Interferon gamma (IFN-gamma) has been implicated in T helper type 1 (Th1) cell development through its ability to optimize interleukin 12 (IL-12) production from macrophages and IL-12 receptor expression on activated T cells. Various systems have suggested a role for IFN-gamma derived from the innate immune system, pa
Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation.: J Exp Med. 1998 Nov 2;188(9):1739-50. Unique Identifier : AIDSLINE MED/99021694; Yang L; Cohn L; Zhang DH; Homer R; Ray A; Ray P; Department of Internal Medicine, Pulmonary and Critical Care; Section, Yale University School of Medicine, New Haven,; Connecticut 06520, USA.; The molecular mechanisms that contribute to an eosinophil-rich airway inflammation in asthma are unclear. A predominantly T helper 2 (Th2)-type cell response has been documented in allergic asthma. Here we show that mice deficient in the p50 subunit of nuclear factor (NF)- kappaB are incapable of mounting eosinophilic
Recognition of measles virus-infected cells by CD8+ T cells depends on the H-2 molecule.: J Gen Virol. 1998 Nov;79 ( Pt 11):2583-91. Unique Identifier : AIDSLINE MED/99036019; Neumeister C; Niewiesk S; Institute of Virology and Immunobiology, University of Wurzburg,; Germany.; H-2d mice are resistant to measles virus-induced encephalitis (MVE) and develop Ld-restricted CD8+ T cells which lyse target cells infected with measles virus or with a vaccinia virus recombinant expressing the nucleocapsid protein of measles virus (vvN). In contrast, H-2k mice are susceptible to MVE and generate CD8+
Intracellular IFN-gamma expression in natural killer cells precedes lung CD8+ T cell recruitment during respiratory syncytial virus infection.: J Gen Virol. 1998 Nov;79 ( Pt 11):2593-601. Unique Identifier : AIDSLINE MED/99036020; Hussell T; Openshaw PJ; Respiratory Medicine, National Heart and Lung Institute, Imperial; College School of Medicine, Paddington, London, UK.; t.hussell@ic.ac.uk; Natural killer (NK) cells are recruited locally during the initial phases of virus infection and produce cytokines which may affect the subsequent emergence of specific T cells. In this study, cellular responses to primary respiratory syncytial virus (RSV) infection and after vaccination with individual viral proteins
Evidence for a post-Columbian introduction of human T-cell lymphotropic virus in Latin America.: J Gen Virol. 1998 Nov;79 ( Pt 11):2695-708. Unique Identifier : AIDSLINE MED/99036031; Van Dooren S; Gotuzzo E; Salemi M; Watts D; Audenaert E; Duwe S; Ellerbrok H; Grassmann R; Hagelberg E; Desmyter J; Vandamme AM; Rega Institute for Medical Research, KU Leuven, Belgium.; To investigate the origin and dissemination of human T-cell lymphotropic virus type I in Latin America, we performed phylogenetic analysis on the LTR and env sequences of 13 HTLV-I isolates from Peruvians of four different ethnic groups: blacks and some mulattos of African origin; Quechuas of Inca origin; Nikkei of Ja
The neutralizing antibody response against a conserved region of human immunodeficiency virus type 1 gp41 (amino acid residues 731-752) is uniquely directed against a conformational epitope.: J Gen Virol. 1998 Nov;79 ( Pt 11):2709-16. Unique Identifier : AIDSLINE MED/99036032; Buratti E; McLain L; Tisminetzky S; Cleveland SM; Dimmock NJ; Baralle FE; International Centre for Genetic Engineering and Biotechnology,; Padriciano, Trieste, Italy.; Amino acids 731-752 (731PRGPDRPEGIEEEGGERDRDRS752) of the transmembrane glycoprotein gp41 of human immunodeficiency virus type 1 (HIV-1) are conserved in most virus isolates and are controversially reported to be implicated in virus neutralization. The humoral response in infected patients against this region is poor
Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) zeta chain leads to TCR down-modulation.: J Gen Virol. 1998 Nov;79 ( Pt 11):2717-27. Unique Identifier : AIDSLINE MED/99036033; Bell I; Ashman C; Maughan J; Hooker E; Cook F; Reinhart TA; Immunopathology Unit, Glaxo Wellcome Medicines Research Centre,; Stevenage, UK.; The Nef protein of simian immunodeficiency virus (SIV) is dispensable for replication in established T-cell lines but essential for high level virus replication in the adult host, though the mechanism by which Nef contributes to this has remained unclear. We demonstrate here that SIV Nef binds to the zeta chain of the
Feline CD8+ T cell non-cytolytic anti-feline immunodeficiency virus activity mediated by a soluble factor(s).: J Gen Virol. 1998 Nov;79 ( Pt 11):2729-35. Unique Identifier : AIDSLINE MED/99036034; Hohdatsu T; Okubo M; Koyama H; Department of Veterinary Infectious Diseases, School of; Veterinary Medicine and Animal Sciences, Kitasato University,; Towada, Aomori, Japan. hohdatsu@vmas.kitasato-u.ac.jp; Feline immunodeficiency virus (FIV) is more readily isolated from CD8+ T cell-depleted peripheral blood mononuclear cells (PBMC) of FIV-infected cats than from unfractionated PBMC cultures. However, it is not known whether feline CD8+ T cells down-regulate FIV expression by direct interaction with FIV-infected cells o
Diversity of naturally occurring Epstein-Barr virus revealed by nucleotide sequence polymorphism in hypervariable domains in the BamHI K and N subgenomic regions.: J Gen Virol. 1998 Nov;79 ( Pt 11):2809-17. Unique Identifier : AIDSLINE MED/99036044; Triantos D; Boulter AW; Leao JC; Di Alberti L; Porter SR; Scully CM; Birnbaum W; Johnson NW; Teo CG; Virus Reference Division, Central Public Health Laboratory,; London, UK.; The extent of nucleotide sequence microheterogeneity varies among subgenomic regions of Epstein-Barr virus (EBV). We examined, in EBV-carrying lymphoid cell lines, the extent of polymorphism in EBV DNA fragments amplified from the BamHI E, K, N and Z regions, and then investigated the diversity of the more hypervariab
Interleukin 12 enhances deficient HCV-antigen-induced Th1-type immune response of peripheral blood mononuclear cells.: J Med Virol. 1998 Oct;56(2):112-7. Unique Identifier : AIDSLINE MED/98417147; Schlaak JF; Pitz T; Lohr HF; Meyer zum Buschenfelde KH; Gerken G; First Department of Medicine, University of Mainz, Germany.; The aim of this study was to examine the possible immunomodulating effects of rhIL-12 on the immune response induced by different hepatitis C virus (HCV) antigens. Freshly isolated peripheral blood mononuclear cells (PBMC) of 33 patients with chronic HCV infection were stimulated with optimal concentrations of antigen
High prevalence of GB virus C/hepatitis G virus infection among homosexual men infected with human immunodeficiency virus type 1: evidence for sexual transmission.: Unique Identifier : AIDSLINE MED/98417149; Nerurkar VR; Chua PK; Hoffmann PR; Dashwood WM; Shikuma CM; Yanagihara R; Retrovirology Research Laboratory, Pacific Biomedical Research; Center, University of Hawaii, Honolulu, USA. nerurkar@hawaii.edu; GB virus C/hepatitis G virus (GBV-C/HGV), a recently discovered orphan flavivirus, is distantly related to hepatitis C virus (HCV). Although both GBV-C/HGV and HCV can be transmitted by the parenteral route, their principal modes of transmission and associated risk behaviors may differ. Using reverse transcription-pol
Evaluation of the detection of human papillomavirus genotypes in cervical specimens by hybrid capture as screening for precancerous lesions in HIV-positive women.: J Med Virol. 1998 Oct;56(2):133-7. Unique Identifier : AIDSLINE MED/98417151; Uberti-Foppa C; Origoni M; Maillard M; Ferrari D; Ciuffreda D; Mastrorilli E; Lazzarin A; Lillo F; Department of Infectious Diseases, IRCCS San Raffaele Hospital; and University of Milan, Italy.; Given the frequency and persistence of human papillomavirus (HPV) infection and associated cytological alterations in HIV-1-positive women, the incidence of uterine cervix neoplasm is likely to increase along with patient survival. More appropriate screening programs, which, in addition to Pap smears (PS), also includ
False negativity by an anti-HIV assay kit (IMx 8B32) and evaluation of its replacement (IMx 8C98).: J Med Virol. 1998 Oct;56(2):138-44. Unique Identifier : AIDSLINE MED/98417152; Parry JV; Perry KR; Harbour S; Burgess C; Mortimer PP; Blackburn NK; Martin D; Virus Reference Division, Central Public Health Laboratory,; London, United Kingdom.; False negativity in a commercial anti-HIV kit (IMx HIV-1/HIV-2 3rd Generation Plus (code 8B32) was investigated, and the kit that superseded it (IMx HIV-1/HIV-2 III Plus, code 8C98) was evaluated. In a comparison on 574 freshly collected anti-HIV-1-positive specimens, 97.2% were more reactive in 8C98 than in 8B32; 35.
Hepatitis C and human immunodeficiency virus RNA degradation by methylene blue/light treatment of human plasma.: J Med Virol. 1998 Nov;56(3):239-45. Unique Identifier : AIDSLINE MED/98455013; Muller-Breitkreutz K; Mohr H; Blood Center of the German Red Cross Chapters of NSOB, Institute; Springe.; Treatment of human plasma with methylene blue in combination with visible light (MB/light) inactivates several bloodborne viruses such as retro viruses and herpes viruses. The viral nucleic acid is thought to be a critical target for the inactivation procedure. We investigated the effects of photodynamic treatment on
Role of HIV-1 phenotype in viral pathogenesis and its relation to viral load and CD4+ T-cell count.: J Med Virol. 1998 Nov;56(3):259-63. Unique Identifier : AIDSLINE MED/98455016; Kupfer B; Kaiser R; Rockstroh JK; Matz B; Schneweis KE; Institute of Medical Microbiology and Immunology, University of; Bonn, Germany.; The predictive value of HIV-1 phenotype in peripheral blood mononuclear cell (PBMC) coculture and the relation among viral phenotype, viral load, and CD4+ T-cell count were examined in two studies. In study A, 132 HIV-1-infected individuals were examined retrospectively for the relation between the result of their ini
Neutralization of HIV-1 subtypes: implications for vaccine formulations.: J Med Virol. 1998 Nov;56(3):264-8. Unique Identifier : AIDSLINE MED/98455017; Smith TL; van Rensburg EJ; Engelbrecht S; Department of Medical Virology, University of Stellenbosch and; Tygerberg Hospital, South Africa.; More than 20.8 million people are infected with HIV in sub-Saharan Africa, with South Africa having one of the fastest growing HIV-1 epidemics, where an estimated 2.4 million people were infected. Thirty-two sera from 25 patients were tested for their ability to neutralize HTLV-II
Ethnic cluster of HTLV-I infection in Israel among the Mashhadi Jewish population.: J Med Virol. 1998 Nov;56(3):269-74. Unique Identifier : AIDSLINE MED/98455018; Miller M; Achiron A; Shaklai M; Stark P; Maayan S; Hannig H; Hunsmann G; Bodemer W; Shohat B; Department of Cell Biology and Histology, Sackler School of; Medicine, Tel Aviv University, Israel.; A high prevalence of human T-lymphotropic virus type I (HTLV-I) infection among Israeli Jews was previously reported. In the present study, screening for HTLV-I of Israeli Jews was expanded to 10 ethnic groups. HTLV-I antibodies were tested by the particle agglutination assay, ELISA, and by Western blot as a confirmat
Extracellular glutamate levels are chronically elevated in the brains of LP-BM5-infected mice: a mechanism of retrovirus-induced encephalopathy.: J Neurochem. 1998 Nov;71(5):2079-87. Unique Identifier : AIDSLINE MED/99013277; Espey MG; Kustova Y; Sei Y; Basile AS; Laboratory of Neuroscience, National Institute of Digestive; Disorders and Kidney, National Institutes of Health, Bethesda,; Maryland 20892-0008, USA.; Mice infected with the LP-BM5 leukemia retrovirus mixture develop a progressive immunodeficiency with associated behavioral, histological, and neurochemical alterations consistent with glutamatergic hyperactivation. To gain insight into the contribution of excitatory amino acids to the neurodegeneration observed in th
Pyranocoumarins from tropical species of the genus Calophyllum: a chemotaxonomic study of extracts in the National Cancer Institute collection.: J Nat Prod. 1998 Oct;61(10):1252-6. Unique Identifier : AIDSLINE MED/99003371; McKee TC; Covington CD; Fuller RW; Bokesch HR; Young S; Cardellina II JH; Kadushin MR; Soejarto DD; Stevens PF; Cragg GM; Boyd MR; Laboratory of Drug Discovery Research and Development,; Developmental Therapeutics Program, Division of Cancer Treatment; and Diagnosis, National Cancer Institute, Building 1052, Room; 121, Frederick, Maryland 21702-1201, USA.; (+)-Calanolide A, a novel dipyranocoumarin from the Malesian tree Calophyllum lanigerum var. austrocoriaceum, and a closely related compound, (-)-calanolide B, isolated from Calophyllum teysmannii var. inophylloide, are representatives of a distinct class of nonnucleoside HIV-1 specific reverse-transcriptase inhibitor
Debromosceptrin, an alkaloid from the Caribbean sponge Agelas conifera.: J Nat Prod. 1998 Oct;61(10):1302-3. Unique Identifier : AIDSLINE MED/99003385; Shen X; Perry TL; Dunbar CD; Kelly-Borges M; Hamann MT; Department of Pharmacognosy, NCDNP, School of Pharmacy, The; University of Mississippi, USA.; As the result of a structurally guided isolation to identify lead compounds for the treatment of opportunistic infections of AIDS, the dihydrochloride salt of a new symmetrical pyrrole dimer debromosceptrin (1), and two known pyrrole analogues (2 and 3) were isolated from the Caribbean sponge Agelas coniferacollected
Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids.: J Nat Prod. 1998 Sep;61(9):1090-5. Unique Identifier : AIDSLINE MED/98422513; Kashiwada Y; Wang HK; Nagao T; Kitanaka S; Yasuda I; Fujioka T; Yamagishi T; Cosentino LM; Kozuka M; Okabe H; Ikeshiro Y; Hu CQ; Yeh E; Lee KH; Natural Products Laboratory, Division of Medicinal Chemistry and; Natural Products, School of Pharmacy, University of North; Carolina, Chapel Hill, North Carolina 27599, USA.; Oleanolic acid (1) was identified as an anti-HIV principle from several plants, including Rosa woodsii (leaves), Prosopis glandulosa (leaves and twigs), Phoradendron juniperinum (whole plant), Syzygium claviflorum (leaves), Hyptis capitata (whole plant), and Ternstromia gymnanthera (aerial part). It inhibited HIV-1 re
HTLV-I-associated myelopathy associated with multi-organ inflammatory disease: a case report.: J Neurol Sci. 1998 Apr 15;157(1):109-12. Unique Identifier : AIDSLINE MED/98261313; Furuya T; Nakamura T; Goto H; Shirabe S; Nomata K; Kitaoka T; Kohno S; Nakamura H; Yoshimura T; Eguchi K; The First Department of Internal Medicine, Nagasaki University; School of Medicine, Japan.; We report a 73-year-old man with human T-lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM) complicated with multi-organ inflammatory disease, including Sjogren s syndrome, interstitial cystitis, and uveitis. The presence of HTLV-I proviral DNA in peripheral blood mononuclear cells (PBMC), cerebrospinal fl
The value of cerebrospinal fluid antiviral antibody in the diagnosis of neurologic disease produced by varicella zoster virus.: J Neurol Sci. 1998 Aug 14;159(2):140-4. Unique Identifier : AIDSLINE MED/98412428; Gilden DH; Bennett JL; Kleinschmidt-DeMasters BK; Song DD; Yee AS; Steiner I; Department of Neurology, University of Colorado Health Sciences; Center, Denver 80262, USA. don.gilden@uchsc.edu; We studied four patients with subacute to chronic varicella zoster virus (VZV) infection of the central nervous system (CNS). VZV infection was verified by detecting antibody to VZV in the cerebrospinal fluid (CSF). VZV caused myelitis in two patients and encephalitis in two patients. In one of the patients with VZV e
Profound cerebrospinal fluid pleocytosis and Froin's Syndrome secondary to widespread necrotizing vasculitis in an HIV-positive patient with varicella zoster virus encephalomyelitis.: J Neurol Sci. 1998 Aug 14;159(2):213-8. Unique Identifier : AIDSLINE MED/98412441; Kleinschmidt-DeMasters BK; Mahalingam R; Shimek C; Marcoux HL; Wellish M; Tyler KL; Gilden DH; Department of Pathology, University of Colorado Health Sciences; Center, Denver 80262, USA.; Demonstration of the direct involvement of cranial blood vessels by varicella zoster virus (VZV) is facilitated by immunohistochemistry (IHC), in situ hybridization (ISH) and polymerase chain reaction (PCR) techniques. The extent to which an inflammatory vasculitis serves as the pathogenic mechanism for VZV encephalom
Clinical, histological and molecular reversibility of zidovudine myopathy.: J Neurol Sci. 1998 Aug 14;159(2):226-8. Unique Identifier : AIDSLINE MED/98412443; Masanes F; Barrientos A; Cebrian M; Pedrol E; Miro O; Casademont J; Grau JM; Department of Medicine, IDIBAPS, Hospital Clinic, University of; Barcelona, Spain.; The use of zidovudine in the treatment of human immunodeficiency virus infection has been associated with toxic mitochondrial myopathy. There are some reported cases of improvement after stopping the drug, but in only one were molecular studies performed. We therefore studied three patients with toxic
Progressive multifocal leukoencephalopathy presenting as a solitary gray matter lesion [letter]: J Neurol. 1998 Aug;245(8):557-8. Unique Identifier : AIDSLINE MED/98418718; Bienfait HP; Louwerse ES; Portegies P; van der Meer JT
A branch-and-bound method for optimal atom-type assignment in de novo ligand design.: J Comput Aided Mol Des. 1998 Jul;12(4):335-49. Unique Identifier : AIDSLINE MED/98450667; Todorov NP; Dean PM; Department of Pharmacology, University of Cambridge, U.K.; This paper investigates a computational procedure for the determination of the atom types on the vertices of a molecular skeleton to optimize interaction with the receptor site whilst maintaining a synthetically reasonable structure. The connectivity of the skeleton is analysed and appropriate atom types are compiled
Prognostic factors in the treatment of human immunodeficiency virus-associated non-Hodgkin's lymphoma: analysis of AIDS Clinical Trials Group protocol 142--low-dose versus standard-dose m-BACOD plus granulocyte-macrophage colony-stimulating factor. National Institute of Allergy and Infectious Diseases.: J Clin Oncol. 1998 Nov;16(11):3601-6. Unique Identifier : AIDSLINE MED/99032193; Straus DJ; Huang J; Testa MA; Levine AM; Kaplan LD; Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.; strausd@mskcc.org; PURPOSE: The overall results of chemotherapy in human immunodeficiency virus (HIV)-associated non-Hodgkin s lymphoma (NHL) have been poor. To define a subgroup of patients who may have a better outcome, an analysis of prognostic factors was performed of patients treated in AIDS Cli
Congenital and perinatal tuberculosis: discussion of difficult issues in diagnosis and management.: J Perinatol. 1998 Sep-Oct;18(5):389-94. Unique Identifier : AIDSLINE MED/98437808; Hageman JR; Department of Pediatrics, Evanston Northwestern Healthcare, IL,; USA.; Tuberculosis (TB) has become more prevalent in women of childbearing age and, as well, more frequent in their children. This has occurred for a number of reasons, including: (1) women and children who have immigrated to this country from areas where TB is endemic, such as Mexico an
HIV/AIDS patients' perspectives on adhering to regimens containing protease inhibitors.: J Gen Intern Med. 1998 Sep;13(9):586-93. Unique Identifier : AIDSLINE MED/98425484; Stone VE; Clarke J; Lovell J; Steger KA; Hirschhorn LR; Boswell S; Monroe AD; Stein MD; Tyree TJ; Mayer KH; Department of Medicine, Memorial Hospital of Rhode Island,; Pawtucket 02860, USA.; OBJECTIVE: To gather qualitative data regarding HIV/AIDS patients perspectives about HIV-1 protease inhibitors (PIs), and about their experiences taking and adhering to regimens containing PIs. DESIGN: Six focus groups of persons under care for HIV were conducted b
The clinical spectrum in a large kindred with autoimmune lymphoproliferative syndrome caused by a Fas mutation that impairs lymphocyte apoptosis.: J Pediatr. 1998 Nov;133(5):629-33. Unique Identifier : AIDSLINE MED/99038860; Infante AJ; Britton HA; DeNapoli T; Middelton LA; Lenardo MJ; Jackson CE; Wang J; Fleisher T; Straus SE; Puck JM; Department of Pediatrics, University of Texas Health Science; Center at San Antonio 78284-7810, USA.; Autoimmune lymphoproliferative syndrome (ALPS) is characterized by chronic, histologically benign splenomegaly and generalized lymphadenopathy, hypergammaglobulinemia, and autoantibody formation. ALPS has been attributed to defective programmed cell death of lymphocytes, most often arising as a result of mutations in
Alveolar bone levels in AIDS and HIV seropositive patients and in control subjects.: J Periodontol. 1998 Sep;69(9):1056-61. Unique Identifier : AIDSLINE MED/98446930; Persson RE; Hollender LG; Persson GR; Department of Oral Medicine, University of Washington, Seattle; 98195, USA. rigmor@u.washington.edu; Alveolar bone levels were studied from intraoral radiographs of 24 non-hospitalized patients with AIDS, 17 HIV seropositive subjects, and 39 matched control subjects. The AIDS/HIV subjects were seeking dental care in a faculty practice. The matched control subjects came from those non-HIV-infected patients seeking den
The pharmacokinetics of saquinavir: a Markov chain Monte Carlo population analysis.: J Pharmacokinet Biopharm. 1998 Feb;26(1):47-74. Unique Identifier : AIDSLINE MED/98446569; Lunn DJ; Aarons L; Department of Epidemiology and Public Health, Imperial College; School of Medicine at St. Mary's, London, United Kingdom.; Saquinavir is an HIV proteinase inhibitor marketed as a treatment for HIV infection. The drug has potent (Ki approximately 0.1 nM) antiviral activity and acts by inhibiting the processing of gag and gag-pol polyproteins, thus blocking the maturation of replicated viral particles. By assuming standard two-compartment d
Drug delivery of antisense molecules to the brain for treatment of Alzheimer's disease and cerebral AIDS.: J Pharm Sci. 1998 Nov;87(11):1308-15. Unique Identifier : AIDSLINE MED/99030477; Boado RJ; Tsukamoto H; Pardridge WM; Department of Medicine and Brain Research Institute, UCLA School; of Medicine, Los Angeles, California 90095, USA.; rboado@med1.medsch.ucla.edu; Antisense oligonucleotides (ODNs) and peptide nucleic acids (PNAs) are potential therapeutics for eradication of malignancies, viral infections, and other pathologies. However, ODNs and PNAs in general are unable to cross cellular membranes and blood-tissue barriers, such as the blood-brain barrier (BBB), which is onl
Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics.: J Pharm Sci. 1998 Nov;87(11):1322-30. Unique Identifier : AIDSLINE MED/99030479; Wacher VJ; Silverman JA; Zhang Y; Benet LZ; AvMax Inc., 890 Heinz Avenue, Berkeley, California, 94710 and; Department of Biopharmaceutical Sciences, University of; California, San Francisco, California 94143-0446, USA.; vwacher@worldnet.att.net; Cytochrome P450 3A4 (CYP3A4), the major phase I drug metabolizing enzyme in humans, and the MDR1 gene product P-glycoprotein (P-gp) are present at high concentrations in villus tip enterocytes of the small intestine and share a significant overlap in substrate specificity. A large body of research both in vitro and in
Trauma-induced Kaposi's sarcoma of the hallux. An unusual case.: J Am Podiatr Med Assoc. 1998 Oct;88(10):500-5. Unique Identifier : AIDSLINE MED/99008167; Berkowitz KD; Bonner AC; Makimaa B; Flash JP; Sasken H; Blaise JF; Mount Sinai Medical Center, Miami Beach, FL, USA.; Kaposi s sarcoma is the most common malignant lesion in patients who test seropositive for the human immunodeficiency virus. Although many cases of this tumor have been described in the literature, only a few cases have been related to Koebner s phenomenon following trauma. Biopsy of lesions remains the standard metho
Detection of Epstein-Barr virus (EBV) DNA and antigens in oral mucosa of renal transplant patients without clinical evidence of oral hairy leukoplakia (OHL).: J Oral Pathol Med. 1998 Oct;27(9):420-7. Unique Identifier : AIDSLINE MED/99004755; Ammatuna P; Capone F; Giambelluca D; Pizzo I; D'Alia G; Margiotta V; Department of Hygiene and Microbiology, University of Palermo,; Italy.; The use of the polymerase chain reaction (PCR) to detect the presence of Epstein-Barr virus (EBV) DNA in oral mucosa in the absence of specific lesions gives rise to the problem of identifying the real viral replication sites. To verify whether the detection of EBV is due to salivary contamination or its true replicat
College students' AIDS risk perception.: J Psychosoc Nurs Ment Health Serv. 1998 Sep;36(9):25-30. Unique Identifier : AIDSLINE MED/98433091; Brown EJ; Center for Urban Health Research, University of Pennsylvania,; School of Nursing, Philadelphia 19104, USA.; 1. Students in this study appraised their AIDS risk using their sexual and drug-use behavior as criteria, which accurately reflects their knowledge of HIV transmission. 2. AIDS risk perceptions were not always congruent with the students self-reported sexual and drug use behavior. Some students reporting high-risk be
Tuberculosis: an international perspective.: J R Coll Physicians Lond. 1998 Jul-Aug;32(4):309-14. Unique Identifier : AIDSLINE MED/98435370; Maher D; Nunn P; Tuberculosis Research Unit, Global Tuberculosis Programme, World; Health Organization, Geneva.
Shared care in HIV and AIDS: shifting care or shifting costs?: J R Coll Physicians Lond. 1998 Jul-Aug;32(4):376-9. Unique Identifier : AIDSLINE MED/98435383; Cartledge JD; Weller IV; Department of Genitourinary Medicine, Camden and Islington; Community Health Services, London.
Update on vertical HIV transmission.: J Reprod Med. 1998 Aug;43(8):637-46. Unique Identifier : AIDSLINE MED/98421254; Groginsky E; Bowdler N; Yankowitz J; Department of Obstetrics and Gynecology, University of Iowa; College of Medicine, Iowa City, USA.; OBJECTIVE: To describe the factors that contribute to vertical transmission of human immunodeficiency virus (HIV) and review means of decreasing the risk of transmission. STUDY DESIGN: Medline search of the international English-language literature pertaining to HIV in pregnancy from 1989 to the present. Special empha
6-Substituted 2,4-diaminopyrido[3,2-d]pyrimidine analogues of piritrexim as inhibitors of dihydrofolate reductase from rat liver, Pneumocystis carinii, and Toxoplasma gondii and as antitumor agents.: J Med Chem. 1998 Nov 5;41(23):4533-41. Unique Identifier : AIDSLINE MED/99024034; Gangjee A; Zhu Y; Queener SF; Division of Medicinal Chemistry, Graduate School of; Pharmaceutical Sciences, Duquesne University, Pittsburgh,; Pennsylvania 15282, USA.; The synthesis and biological activity are reported for 21 6-substituted 2,4-diaminopyrido[3,2-d]pyrimidine analogues (4-24) of piritrexim (PTX) as inhibitors of dihydrofolate reductase (DHFR) and as antitumor agents. Recombinant DHFR from Pneumocystis carinii (pc) and native DHFR from Toxoplasma gondii (tg) were the t
Abasic analogues of TSAO-T as the first sugar derivatives that specifically inhibit HIV-1 reverse transcriptase.: J Med Chem. 1998 Nov 5;41(23):4636-47. Unique Identifier : AIDSLINE MED/99024045; Velazquez S; Chamorro C; Perez-Perez MJ; Alvarez R; Jimeno ML; Martin-Domenech A; Perez C; Gago F; De Clercq E; Balzarini J; San-Felix A; Camarasa MJ; Instituto de Quimica Medica, C.S.I.C., Juan de la Cierva 3,; 28006 Madrid, Spain.; With the aim of assessing the role that the thymine base of TSAO-T may play in the interaction of TSAO compounds with HIV-1 reverse transcriptase (RT), we have designed, synthesized, and evaluated for their anti-HIV-1 activity a series of 3-spiro sugar derivatives substituted at the anomeric position with nonaromatic
Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents.: J Med Chem. 1998 Nov 5;41(23):4648-57. Unique Identifier : AIDSLINE MED/99024046; Sun IC; Wang HK; Kashiwada Y; Shen JK; Cosentino LM; Chen CH; Yang LM; Lee KH; Natural Products Laboratory, Division of Medicinal Chemistry and; Natural Products, School of Pharmacy, University of North; Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7360,; USA.; Succinyl and 3 -substituted glutaryl betulin derivatives showed stronger anti-HIV activity and higher therapeutic index (TI) values than their dihydrobetulin counterparts, with ratios of 1.2:1 to 15:1 (cf. 7 and 15, 9 and 17, 10 and 18, 11 and 19, and 12 and 20). For various 3 -substituted glutaryl compounds, the orde
Comparative susceptibilities of various AIDS-associated and human urogenital tract mycoplasmas and strains of Mycoplasma pneumoniae to 10 classes of antimicrobial agent in vitro.: J Med Microbiol. 1998 Dec;47(12):1115-22. Unique Identifier : AIDSLINE MED/99072468; Hannan PC; Mycoplasma Experience Ltd, Reigate, Surrey.; The susceptibilities of 40 strains of various Mycoplasma species to 10 classes of antimicrobial agents were compared in vitro by a broth microdilution method. The strains tested comprised 20 strains of four AIDS-associated species--M. penetrans (1 strain), M. fermentas (5 strains), M. pirum (6 strains) and M. genitali
An evaluation of the cost-effectiveness of using CHROMagar for yeast identification in a routine microbiology laboratory.: J Med Microbiol. 1998 Jul;47(7):623-8. Unique Identifier : AIDSLINE MED/99053302; Ainscough S; Kibbler CC; Department of Medical Microbiology, Royal Free Hospital School of; Medicine, London.; CHROMagar, a chromogenic differential culture medium, is claimed to facilitate the isolation and presumptive identification of certain clinically important yeast species, e.g., Candida albicans. This study evaluated the cost-effectiveness and time advantage of using it in comparison with Sabouraud dextrose agar (SDA).
CD8 lymphocytes in HIV infection: helpful and harmful.: J Clin Lab Immunol. 1997;49(1):15-32. Unique Identifier : AIDSLINE MED/99037105; Famularo G; Moretti S; Marcellini S; Nucera E; De Simone C; Department of Experimental Medicine, University of L'Aquila,; Italy.; The part played by CD8 lymphocytes in the pathogenesis of human immunodeficiency virus infection (HIV) is much disputed and the relevant issue of the controversy ranges as to whether the functional activity of these cells is beneficial or detrimental to the host. Even though CD8 cells could efficiently suppress HIV re
Common variable immunodeficiency following Epstein-Barr virus infection.: J Clin Lab Immunol. 1997;49(1):41-5. Unique Identifier : AIDSLINE MED/99037107; Zuccaro G; Della Bella S; Polizzi B; Vanoli M; Scorza R; Institute of Internal Medicine, Infectious Diseases and; Immunopathology, University of Milan, Italy.; The authors present a case of a patient who developed recurrent bacterial upper respiratory and pulmonary infections and marked hypogammaglobulinemia with a gradual decrease of serum IgG, IgA and IgM some months after acute Epstein-Barr virus infection. Test for identification of lymphocyte subpopulation showed increa
Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance.: J Mol Biol. 1998 Nov 27;284(2):313-23. Unique Identifier : AIDSLINE PDB/1BQN; Hsiou Y; Das K; Ding J; Clark AD Jr; Kleim JP; Rosner M; Winkler I; Riess G; Hughes SH; Arnold E; Center for Advanced Biotechnology and Medicine (CABM) and Rutgers; University Chemistry Department, 679 Hoes Lane, Piscataway, NJ,; 08854-5638, USA.; The second generation Hoechst-Bayer non-nucleoside inhibitor, HBY 097 (S-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3, 4-dihydroqui noxalin-2(1H)-thione), is an extremely potent inhibitor of HIV-1 reverse transcriptase (RT) and of HIV-1 infection in cell culture. HBY 097 selects for unusual drug-resistance mu
AZT decreases rat myocardial cytochrome oxidase activity and increases beta-myosin heavy chain content.: J Mol Cell Cardiol. 1998 Oct;30(10):1979-89. Unique Identifier : AIDSLINE MED/99018065; McCurdy DT 3rd; Kennedy JM; Cardiology Unit and Department of Molecular Physiology and; Biophysics, University of Vermont, Given Building, Room E209,; Burlington, VT 05405, USA.; AZT , a widely-utilized drug for the treatment of HIV infection, inhibits the polymerase responsible for mitochondrial DNA replication (mtDNA). The aim of this study was to assess myocardial alterations caused by this action. Ventricular muscle from ra
Blood transfusions and the risk of intermediate- or high-grade non-Hodgkin's lymphoma.: J Natl Cancer Inst. 1998 Nov 18;90(22):1742-3. Unique Identifier : AIDSLINE MED/99043203; Nelson RA; Levine AM; Bernstein L; Department of Preventive Medicine, Norris Comprehensive Cancer; Center, University of Southern California School of Medicine, Los; Angeles 90033, USA.
Human immunodeficiency virus/acquired immunodeficiency syndrome crisis.: J Natl Med Assoc. 1998 Nov;90(11):643-4. Unique Identifier : AIDSLINE MED/99046017; Dennis GC
Neuropsychological functioning in HIV-positive African-American women with a history of drug use.: Unique Identifier : AIDSLINE MED/99046021; Mason KI; Campbell A; Hawkins P
Dynamic Recovery: comparative study of therapeutic communities in homeless shelters for men.: J Subst Abuse Treat. 1998 Sep-Oct;15(5):401-23. Unique Identifier : AIDSLINE MED/98423572; Liberty HJ; Johnson BD; Jainchill N; Ryder J; Messina M; Reynolds S; Hossain M; National Development and Research Institutes, Inc., New York, NY; 10048, USA. hilary.liberty@ndri.org; The Dynamic Recovery Project examined relationships between homelessness, substance abuse, and recovery, and investigated the effectiveness of the therapeutic community (TC) treatment model in helping homeless drug users move toward stable, drug-free living. This project compared two short-term TCs that were situated
Lymphoepithelial cyst of the parotid gland--a case report.: Kao Hsiung I Hsueh Ko Hsueh Tsa Chih. 1998 Nov;14(11):738-42. Unique Identifier : AIDSLINE MED/99056150; Chiang CH; Chiang FY; Lin CH; Juan KH; Department of Otorhinolaryngology, Provincial Ping-Tung General; Hospital, Taiwan, Republic of China.; The lymphoepithelial cyst has been commonly termed branchial cleft cyst or branchial cyst. Although many theories, including the branchial apparatus theory, thymic duct theory, and inclusion theory, have been put forward, the etiology is still controversial. Parotid lymphoepithelial cysts are rare and could be divided
Pediatric tuberculosis in rural South Africa--value of directly observed therapy.: J Trop Pediatr. 1998 Oct;44(5):266-9. Unique Identifier : AIDSLINE MED/99036922; Wilkinson D; Davies GR; Centre for Epidemiological Research, South African Medical; Research Council, Mtubatuba, South Africa.; Tuberculosis is a major cause of mortality and morbidity among children in resource-poor settings. A strategy of community-based, directly observed therapy employed in a rural health district in South Africa since 1991 is described. Most children (75 per cent) diagnosed with tuber
Occult systemic infection and persistent simian immunodeficiency virus (SIV)-specific CD4(+)-T-cell proliferative responses in rhesus macaques that were transiently viremic after intravaginal inoculation of SIV.: J Virol. 1998 Dec;72(12):10029-35. Unique Identifier : AIDSLINE MED/99030913; McChesney MB; Collins JR; Lu D; Lu X; Torten J; Ashley RL; Cloyd MW; Miller CJ; California Regional Primate Research Center, University of; California-Davis, Davis, California 95616, USA.; The intact cervicovaginal mucosa is a relative barrier to the sexual transmission of human immunodeficiency virus type 1 (HIV-1). In the simian immunodeficiency virus (SIV) macaque model of HIV infection, seronegative transient viremia (STV; virus isolation positive followed by repeated negative cultures) occurs after
Multigene tracking of hepatitis C virus quasispecies after liver transplantation: correlation of genetic diversification in the envelope region with asymptomatic or mild disease patterns.: J Virol. 1998 Dec;72(12):10036-43. Unique Identifier : AIDSLINE MED/99030914; Sullivan DG; Wilson JJ; Carithers RL Jr; Perkins JD; Gretch DR; Departments of Laboratory Medicine, University of Washington; Medical Center, Seattle, Washington, USA.; To investigate the role of hepatitis C virus (HCV) quasispecies mutation in the pathogenesis of HCV infection, we analyzed changes in the genetic diversity of HCV genomes in 22 patients before and after liver transplantation by using heteroduplex mobility assay (HMA) technology. All patients were infected with HCV gen
Distinct biology of Kaposi's sarcoma-associated herpesvirus from primary lesions and body cavity lymphomas.: J Virol. 1998 Dec;72(12):10073-82. Unique Identifier : AIDSLINE MED/99030919; Friborg J Jr; Kong WP; Flowers CC; Flowers SL; Sun Y; Foreman KE; Nickoloff BJ; Nabel GJ; Departments of Internal Medicine and Biological Chemistry, Howard; Hughes Medical Institute, University of Michigan Medical Center,; Ann Arbor, Michigan 48109-0650, USA.; The DNA sequence for Kaposi s sarcoma-associated herpesvirus was originally detected in Kaposi s sarcoma biopsy specimens. Since its discovery, it has been possible to detect virus in cell lines established from AIDS-associated body cavity-based B-cell lymphoma and to propagate virus from primary Kaposi s sarcoma lesi
CCR5- and CXCR4-utilizing strains of human immunodeficiency virus type 1 exhibit differential tropism and pathogenesis in vivo.: J Virol. 1998 Dec;72(12):10108-17. Unique Identifier : AIDSLINE MED/99030923; Berkowitz RD; Alexander S; Bare C; Linquist-Stepps V; Bogan M; Moreno ME; Gibson L; Wieder ED; Kosek J; Stoddart CA; McCune JM; Gladstone Institute of Virology and Immunology, San Francisco,; Stanford University, Stanford, and Veterans Hospital, Palo Alto,; California, USA.; CCR5-utilizing (R5) and CXCR4-utilizing (X4) strains of human immunodeficiency virus type 1 (HIV-1) have been studied intensively in vitro, but the pathologic correlates of such differential tropism in vivo remain incompletely defined. In this study, X4 and R5 strains of HIV-1 were compared for tropism and pathogenesi
The vaccinia virus 14-kilodalton (A27L) fusion protein forms a triple coiled-coil structure and interacts with the 21-kilodalton (A17L) virus membrane protein through a C-terminal alpha-helix.: J Virol. 1998 Dec;72(12):10126-37. Unique Identifier : AIDSLINE MED/99030925; Vazquez MI; Rivas G; Cregut D; Serrano L; Esteban M; Centro Nacional de Biotecnologia, CSIC, Campus Universidad; Autonoma, 28049 Madrid, Spain.; The vaccinia virus 14-kDa protein (encoded by the A27L gene) plays an important role in the biology of the virus, acting in virus-to-cell and cell-to-cell fusions. The protein is located on the surface of the intracellular mature virus form and is essential for both the release of extracellular enveloped virus from th
The unique envelope gene of the subgroup J avian leukosis virus derives from ev/J proviruses, a novel family of avian endogenous viruses.: J Virol. 1998 Dec;72(12):10157-64. Unique Identifier : AIDSLINE MED/99030928; Benson SJ; Ruis BL; Fadly AM; Conklin KF; Department of Biochemistry, Molecular Biology, and Biophysics,; University of Minnesota Medical School, Minneapolis, Minnesota; 55455, USA.; A new subgroup of avian leukosis virus (ALV), designated subgroup J, was identified recently. Viruses of this subgroup do not cross-interfere with viruses of the avian A, B, C, D, and E subgroups, are not neutralized by antisera raised against the other virus subgroups, and have a broader host range than the A to E su
HLA compatibility requirements for CD8(+)-T-cell-mediated suppression of human immunodeficiency virus replication.: J Virol. 1998 Dec;72(12):10165-70. Unique Identifier : AIDSLINE MED/99030929; Mackewicz CE; Garovoy MR; Levy JA; Department of Medicine, Department of Surgery, School of; Medicine, University of California, San Francisco, San Francisco,; California 94143-1270, USA.; CD8(+) T cells from human immunodeficiency virus (HIV)-infected individuals can suppress HIV replication in cultured CD4(+) cells by a noncytotoxic mechanism. Efficient suppression of HIV replication (>90% reduction) does not require HLA class I or class II histocompatibility between the effector CD8(+) T cells and th
Enhanced T-cell immunogenicity and protective efficacy of a human immunodeficiency virus type 1 vaccine regimen consisting of consecutive priming with DNA and boosting with recombinant fowlpox virus.: J Virol. 1998 Dec;72(12):10180-8. Unique Identifier : AIDSLINE MED/99030931; Kent SJ; Zhao A; Best SJ; Chandler JD; Boyle DB; Ramshaw IA; AIDS Pathogenesis Research Unit, Macfarlane Burnet Centre for; Medical Research, Fairfield 3078, Victoria, Australia.; kent@burnet.edu.au; The induction of human immunodeficiency virus (HIV)-specific T-cell responses is widely seen as critical to the development of effective immunity to HIV type 1 (HIV-1). Plasmid DNA and recombinant fowlpox virus (rFPV) vaccines are among the most promising safe HIV-1 vaccine candidates. However, the immunity induced by
A conformation-specific monoclonal antibody reacting with fusion-active gp41 from the human immunodeficiency virus type 1 envelope glycoprotein.: J Virol. 1998 Dec;72(12):10213-7. Unique Identifier : AIDSLINE MED/99030935; Jiang S; Lin K; Lu M; Lindsley F. Kimball Research Institute, New York Blood Center,; New York, New York 10021, USA. sjiang@nybc.org; The gp41 subunit of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein plays a major role in the membrane fusion step of viral infection. The ectodomain of gp41 contains a six-helix structural domain that likely represents the core of the fusion-active conformation of the molecule. A monoclonal anti
Equine infectious anemia virus Gag polyprotein late domain specifically recruits cellular AP-2 adapter protein complexes during virion assembly.: J Virol. 1998 Dec;72(12):10218-21. Unique Identifier : AIDSLINE MED/99030936; Puffer BA; Watkins SC; Montelaro RC; Department of Molecular Genetics and Biochemistry, University of; Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261,; USA.; We have identified an interaction between the equine infectious anemia virus (EIAV) late assembly domain and the cellular AP-2 clathrin-associated adapter protein complex. A YXXL motif within the EIAV Gag late assembly domain was previously characterized as a sequence critical for release of assembling virions. We now
An isolate of human immunodeficiency virus type 1 originally classified as subtype I represents a complex mosaic comprising three different group M subtypes (A, G, and I).: J Virol. 1998 Dec;72(12):10234-41. Unique Identifier : AIDSLINE MED/99030939; Gao F; Robertson DL; Carruthers CD; Li Y; Bailes E; Kostrikis LG; Salminen MO; Bibollet-Ruche F; Peeters M; Ho DD; Shaw GM; Sharp PM; Hahn BH; Department of Medicine and Microbiology, University of Alabama at; Birmingham, Birmingham, Alabama 35294, USA.; Full-length reference clones and sequences are currently available for eight human immunodeficiency virus type 1 (HIV-1) group M subtypes (A through H), but none have been reported for subtypes I and J, which have only been identified in a few individuals. Phylogenetic information for subtype I, in particular, is limi
Retrovirus packaging cells expressing the Mus dunni endogenous virus envelope facilitate transduction of CHO and primary hematopoietic cells.: J Virol. 1998 Dec;72(12):10242-5. Unique Identifier : AIDSLINE MED/99030940; Wolgamot G; Rasko JE; Miller AD; Fred Hutchinson Cancer Research Center, Seattle, Washington; 98109, USA.; Mus dunni endogenous virus (MDEV) infects a wide variety of cell types from many different species. To take advantage of this broad host range, we have constructed packaging cells (PD223) that produce virions bearing the MDEV envelope. PD223 cells are able to package Moloney murine leukemia virus-based vectors at a ti
An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein.: J Virol. 1998 Dec;72(12):10251-5. Unique Identifier : AIDSLINE MED/99030942; Madani N; Kabat D; Department of Biochemistry and Molecular Biology, Oregon Health; Sciences University, Portland, Oregon 97201-3098, USA.; The vif gene of human immunodeficiency virus type 1 (HIV-1) encodes a basic Mr 23,000 protein that is necessary for production of infectious virions by nonpermissive cells (human lymphocytes and macrophages) but not by permissive cells such as HeLa-CD4. It had been proposed that permissive cells may contain an unident
Antibody neutralization-resistant primary isolates of human immunodeficiency virus type 1.: J Virol. 1998 Dec;72(12):10270-4. Unique Identifier : AIDSLINE MED/99030946; Parren PW; Wang M; Trkola A; Binley JM; Purtscher M; Katinger H; Moore JP; Burton DR; Departments of Immunology and Molecular Biology, The Scripps; Research Institute, La Jolla, California 92037, USA.; Although typical primary isolates of human immunodeficiency virus type 1 (HIV-1) are relatively neutralization resistant, three human monoclonal antibodies and a small number of HIV-1(+) human sera that neutralize the majority of isolates have been described. The monoclonal antibodies (2G12, 2F5, and b12) represent sp
Vaccine protection against a heterologous, non-syncytium-inducing, primary human immunodeficiency virus.: J Virol. 1998 Dec;72(12):10275-80. Unique Identifier : AIDSLINE MED/99030947; Robert-Guroff M; Kaur H; Patterson LJ; Leno M; Conley AJ; McKenna PM; Markham PD; Richardson E; Aldrich K; Arora K; Murty L; Carter L; Zolla-Pazner S; Sinangil F; Basic Research Laboratory, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892-4255, USA.; guroffm@dc37a.nci.nih.gov; Vaccine-induced protection of chimpanzees against laboratory-adapted and syncytium-inducing, multiply passaged primary human immunodeficiency virus type 1 (HIV-1) isolates, but not against non-syncytium-inducing, minimally passaged ones, has been demonstrated. Following challenge with such an isolate, HIV-15016, we ob
A pathogenic threshold of virus load defined in simian immunodeficiency virus- or simian-human immunodeficiency virus-infected macaques.: J Virol. 1998 Dec;72(12):10281-5. Unique Identifier : AIDSLINE MED/99030948; Ten Haaft P; Verstrepen B; Uberla K; Rosenwirth B; Heeney J; Department of Virology, Biomedical Primate Research Center, 2280; GH Rijswijk, The Netherlands.; To determine if a specific pathogenic threshold of plasma viral RNA could be defined irrespective of virus strain, RNA levels in the plasma of more than 50 infected rhesus macaques (Macaca mulatta) were measured. Animals were inoculated intravenously with either simian immunodeficiency virus (SIV) or simian-human immu
Independent isolates of the emerging subgroup J avian leukosis virus derive from a common ancestor.: J Virol. 1998 Dec;72(12):10301-4. Unique Identifier : AIDSLINE GENBANK/AF097731; Benson SJ; Ruis BL; Garbers AL; Fadly AM; Conklin KF; Department of Biochemistry, Molecular Biology and Biophysics,; University of Minnesota Medical School, Minneapolis, Minnesota; 55455, USA.; A new subgroup of avian leukosis virus (ALV) that includes a unique env gene, designated J, was identified recently in England. Sequence analysis of prototype English isolate HPRS-103 revealed several other unique genetic characteristics of this strain and provided information that it arose by recombination between ex
A novel simian immunodeficiency virus (SIVdrl) pol sequence from the drill monkey, Mandrillus leucophaeus.: J Virol. 1998 Dec;72(12):10305-9. Unique Identifier : AIDSLINE GENBANK/AJ011017; Clewley JP; Lewis JC; Brown DW; Gadsby EL; Virus Reference Division, Central Public Health Laboratory,; London, United Kingdom. jclewley@hgmp.mrc.ac.uk; The drill monkey has been shown by serology and PCR to harbor a unique simian immunodeficiency virus (SIVdrl). A pol sequence, amplified from uncultured peripheral blood cells, is most closely related to the equivalent SIV sequences from the red-capped mangabey (SIVrcm), the sabaeus African green monkey (SIVagmSAB), a
Simian T-cell lymphotropic virus type 1 from Mandrillus sphinx as a simian counterpart of human T-cell lymphotropic virus type 1 subtype D.: J Virol. 1998 Dec;72(12):10316-22. Unique Identifier : AIDSLINE GENBANK/AF082875; Mahieux R; Chappey C; Georges-Courbot MC; Dubreuil G; Mauclere P; Georges A; Gessain A; Unite d'Epidemiologie des Virus Oncogenes, Institut Pasteur,; 75724 Paris Cedex 15, France.; A recent serological and molecular survey of a semifree-ranging colony of mandrills (Mandrillus sphinx) living in Gabon , central Africa, indicated that 6 of 102 animals, all males, were infected with simian T-cell lymphotropic virus type 1 (STLV-1). These animals naturally live in t
Human lymphoblastoid CD4(+) T cells become permissive to macrophage-tropic strains of human immunodeficiency virus type 1 after passage into severe combined immunodeficient mice through in vivo upregulation of CCR5: in vivo dynamics of CD4(+) T-cell differentiation in pathogenesis of AIDS.: Unique Identifier : AIDSLINE MED/99030956; Lapenta C; Parlato S; Spada M; Santini SM; Rizza P; Logozzi M; Proietti E; Belardelli F; Fais S; In this article, we show that passage in SCID mice rendered a
Modulation of immune system function by measles virus infection: role of soluble factor and direct infection.: J Virol. 1998 Dec;72(12):9421-7. Unique Identifier : AIDSLINE MED/99030846; Fujinami RS; Sun X; Howell JM; Jenkin JC; Burns JB; Department of Neurology, University of Utah School of Medicine,; Salt Lake City, Utah 84132, USA. Robert.Fujinami@hsc.utah.edu; Measles virus infection can result in a variety of immunologic defects. We have begun studies to determine the basis for the lack of immune responsiveness to antigen and mitogen following infection. Here we present data showing that Epstein-Barr virus-transformed B-cell lines infected with measles virus produce a solu
Cytokine response in multiple lymphoid tissues during the primary phase of feline immunodeficiency virus infection.: J Virol. 1998 Dec;72(12):9436-40. Unique Identifier : AIDSLINE MED/99030848; Dean GA; Pedersen NC; Department of Microbiology, Pathology, and Parasitology, North; Carolina State University, Raleigh, North Carolina 27606, USA.; Gregg_Dean@ncsu.edu; Type 1 and 2 cytokine mRNA responses were measured at various time periods and in various lymphoid compartments during the acute stage (first 4 months) of feline immunodeficiency virus (FIV) infection in laboratory cats. Cytokine responses were correlated with virus replication. Virus was detected in plasma and tissue
Differential tropism and replication kinetics of human immunodeficiency virus type 1 isolates in thymocytes: coreceptor expression allows viral entry, but productive infection of distinct subsets is determined at the postentry level.: J Virol. 1998 Dec;72(12):9441-52. Unique Identifier : AIDSLINE MED/99030849; Pedroza-Martins L; Gurney KB; Torbett BE; Uittenbogaart CH; Department of Microbiology & Immunology, Los Angeles, and The; Scripps Research Institute, La Jolla, California, USA.; Human thymocytes are readily infected with human immunodeficiency virus type 1 (HIV-1) in vivo and in vitro. In this study, we found that the kinetics of replication and cytopathic effects of two molecular isolates, NL4-3 and JR-CSF, in postnatal thymocytes are best explained by the distribution of chemokine receptors
Simian sarcoma-associated virus fails to infect Chinese hamster cells despite the presence of functional gibbon ape leukemia virus receptors.: J Virol. 1998 Dec;72(12):9453-8. Unique Identifier : AIDSLINE MED/99030850; Ting YT; Wilson CA; Farrell KB; Chaudry GJ; Eiden MV; Laboratory of Cellular and Molecular Regulation, National; Institute of Mental Health, Bethesda, Maryland 20892, USA.; We have sequenced the envelope genes from each of the five members of the gibbon ape leukemia virus (GALV) family of type C retroviruses. Four of the GALVs, including GALV strain SEATO (GALV-S), were originally isolated from gibbon apes, whereas the fifth member of this family, simian sarcoma-associated virus (SSAV),
Control of human immunodeficiency virus type 1 RNA metabolism: role of splice sites and intron sequences in unspliced viral RNA subcellular distribution.: J Virol. 1998 Dec;72(12):9503-13. Unique Identifier : AIDSLINE MED/99030855; Seguin B; Staffa A; Cochrane A; Department of Molecular and Medical Genetics, University of; Toronto, Toronto, Ontario, M5S 1 A8, Canada.; In the course of examining the various factors which affect the metabolism of human immunodeficiency virus type 1 (HIV-1) RNA, we examined the role of intron sequences and splice sites in determining the subcellular distribution of the RNA. Using in situ hybridization, we demonstrated that in the absence of Rev, unspl
Syncytium-inhibiting monoclonal antibodies produced against human T-cell lymphotropic virus type 1-infected cells recognize class II major histocompatibility complex molecules and block by protein crowding.: J Virol. 1998 Dec;72(12):9544-52. Unique Identifier : AIDSLINE MED/99030859; Hildreth JE; Leukocyte Immunochemistry Laboratory, Department of Pharmacology; and Molecular Sciences, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21205, USA. jhildret@jhmi.edu; Four new monoclonal antibodies (MAbs) that inhibit human T-cell lymphotropic virus type 1 (HTLV-1)-induced syncytium formation were produced by immunizing BALB/c mice with HTLV-1-infected MT2 cells. Immunoprecipitation studies and binding assays of transfected mouse cells showed that these MAbs recognize class II majo
Diverse host responses and outcomes following simian immunodeficiency virus SIVmac239 infection in sooty mangabeys and rhesus macaques.: J Virol. 1998 Dec;72(12):9597-611. Unique Identifier : AIDSLINE MED/99030865; Kaur A; Grant RM; Means RE; McClure H; Feinberg M; Johnson RP; Divisions of Immunology, New England Regional Primate Research; Center, Harvard Medical School, Southborough, Massachusetts, USA.; Sooty mangabeys naturally infected with simian immunodeficiency virus (SIV) do not develop immunodeficiency despite the presence of viral loads of 10(5) to 10(7) RNA copies/ml. To investigate the basis of apathogenic SIV infection in sooty mangabeys, three sooty mangabeys and three rhesus macaques were inoculated intr
Gag protein epitopes recognized by ELA-A-restricted cytotoxic T lymphocytes from horses with long-term equine infectious anemia virus infection.: J Virol. 1998 Dec;72(12):9612-20. Unique Identifier : AIDSLINE MED/99030866; Zhang W; Lonning SM; McGuire TC; Department of Veterinary Microbiology and Pathology, Washington; State University, Pullman, Washington 99164-7040, USA.; Most equine infectious anemia virus (EIAV)-infected horses have acute clinical disease, but they eventually control the disease and become lifelong carriers. Cytotoxic T lymphocytes (CTL) are considered an important immune component in the control of infections with lentiviruses including EIAV, but definitive evidence
Cleavage of the murine leukemia virus transmembrane env protein by human immunodeficiency virus type 1 protease: transdominant inhibition by matrix mutations.: J Virol. 1998 Dec;72(12):9621-7. Unique Identifier : AIDSLINE MED/99030867; Kiernan RE; Freed EO; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, Maryland 20892-0460, USA.; We have identified mutations in the human immunodeficiency virus type 1 (HIV-1) matrix protein (MA) which block infectivity of virions pseudotyped with murine leukemia virus (MuLV) envelope (Env) glycoproteins without affecting infectivity conferred by HIV-1 Env or vesicular stomatitis virus G glycoproteins. This inhi
Neutralizing antibodies from the sera of human immunodeficiency virus type 1-infected individuals bind to monomeric gp120 and oligomeric gp140.: J Virol. 1998 Dec;72(12):9656-67. Unique Identifier : AIDSLINE MED/99030871; Stamatos NM; Mascola JR; Kalyanaraman VS; Louder MK; Frampton LM; Birx DL; VanCott TC; Division of Retrovirology, Walter Reed Army Institute of; Research, Rockville, Maryland 20850, USA.; Antibodies that neutralize primary isolates of human immunodeficiency virus type 1 (HIV-1) appear during HIV-1 infection but are difficult to elicit by immunization with current vaccine products comprised of monomeric forms of HIV-1 envelope glycoprotein gp120. The limited neutralizing antibody response generated by g
Mutational analysis of residues in the coiled-coil domain of human immunodeficiency virus type 1 transmembrane protein gp41.: J Virol. 1998 Dec;72(12):9676-82. Unique Identifier : AIDSLINE MED/99030873; Weng Y; Weiss CD; Center for Biologics Evaluation and Research, Food and Drug; Administration, Bethesda, Maryland 20892, USA.; The envelope glycoprotein (Env) of human immunodeficiency virus mediates virus entry into cells by undergoing conformational changes that lead to fusion between viral and cellular membranes. A six-helix bundle in gp41, consisting of an interior trimeric coiled-coil core with three exterior helices packed in the groove
Human immunodeficiency virus induces a dual regulation of Bcl-2, resulting in persistent infection of CD4(+) T- or monocytic cell lines.: J Virol. 1998 Dec;72(12):9698-705. Unique Identifier : AIDSLINE MED/99030875; Aillet F; Masutani H; Elbim C; Raoul H; Chene L; Nugeyre MT; Paya C; Barre-Sinoussi F; Gougerot-Pocidalo MA; Israel N; Unite de Biologie des Retrovirus, Institut Pasteur, 75724 Paris; Cedex 15, France.; This work aims at characterizing the interplay between human immunodeficiency virus type 1 (HIV-1) and the antiapoptotic cellular protein Bcl-2 responsible for a persistent infection in lymphoblastoid T (J.Jhan) or monocytic (U937) cells. We report that the kinetics of Bcl-2 protein level during the establishment of a
T-tropic human immunodeficiency virus type 1 (HIV-1)-derived V3 loop peptides directly bind to CXCR-4 and inhibit T-tropic HIV-1 infection.: J Virol. 1998 Dec;72(12):9763-70. Unique Identifier : AIDSLINE MED/99030883; Sakaida H; Hori T; Yonezawa A; Sato A; Isaka Y; Yoshie O; Hattori T; Uchiyama T; Laboratory of Virus Immunology, Research Center for Acquired; Immunodeficiency Syndrome, Institute for Virus Research, Kyoto; University, Kyoto 606, Japan.; Certain types of chemokine receptors have been identified as coreceptors for HIV-1 infection. The process of viral entry is initiated by the interaction between an envelope protein gp120 of HIV-1, CD4, and one of the relevant coreceptors. To understand the precise mechanism of the Env-mediated fusion and entry of HIV-
Neutralizing monoclonal antibodies block human immunodeficiency virus type 1 infection of dendritic cells and transmission to T cells.: J Virol. 1998 Dec;72(12):9788-94. Unique Identifier : AIDSLINE MED/99030886; Frankel SS; Steinman RM; Michael NL; Kim SR; Bhardwaj N; Pope M; Louder MK; Ehrenberg PK; Parren PW; Burton DR; Katinger H; VanCott TC; Robb ML; Birx DL; Mascola JR; Division of Retrovirology, Walter Reed Army Institute of Research; and Henry M. Jackson Foundation for the Advancement of Military; Medicine, Rockville, Maryland, USA. sfrankel@hiv.hjf.org; Prevention of the initial infection of mucosal dendritic cells (DC) and interruption of the subsequent transmission of HIV-1 from DC to T cells are likely to be important attributes of an effective human immunodeficiency virus type 1 (HIV-1) vaccine. While anti-HIV-1 neutralizing antibodies have been difficult to elic
Influence of cell polarity on retrovirus-mediated gene transfer to differentiated human airway epithelia.: J Virol. 1998 Dec;72(12):9818-26. Unique Identifier : AIDSLINE MED/99030889; Wang G; Davidson BL; Melchert P; Slepushkin VA; van Es HH; Bodner M; Jolly DJ; McCray PB Jr; Departments of Pediatrics, University of Iowa College of; Medicine, Iowa City, Iowa 52242, USA.; Gene transfer with recombinant murine leukemia viruses (MuLV) provides the potential to permanently correct inherited lung diseases, such as cystic fibrosis (CF). Several problems prevent the application of MuLV-based recombinant retroviruses to lung gene therapy: (i) the lack of cell proliferation in mature pulmonary
Zeta chain of the T-cell receptor interacts with nef of simian immunodeficiency virus and human immunodeficiency virus type 2.: J Virol. 1998 Dec;72(12):9827-34. Unique Identifier : AIDSLINE MED/99030890; Howe AY; Jung JU; Desrosiers RC; New England Regional Primate Research Center, Harvard Medical; School, Southborough, Massachusetts 01772-9102, USA.; A truncated version of the nef gene of simian immunodeficiency virus SIVmac239 capable of encoding amino acids 98 to 263 was used as bait to screen a cDNA library from activated lymphocytes in a yeast two-hybrid system. The zeta chain of the T-cell receptor (TCRzeta) was found to interact specifically not only with tr
Study of the V3 loop as a target epitope for antibodies involved in the neutralization of primary isolates versus T-cell-line-adapted strains of human immunodeficiency virus type 1.: J Virol. 1998 Dec;72(12):9855-64. Unique Identifier : AIDSLINE MED/99030893; Spenlehauer C; Saragosti S; Fleury HJ; Kirn A; Aubertin AM; Moog C; INSERM U74, Institut de Virologie, 67000 Strasbourg, France.; Previous studies characterized the third variable (V3) loop of the envelope gp120 as the principal neutralizing determinant for laboratory T-cell-line-adapted (TCLA) strains of human immunodeficiency virus type 1 (HIV-1). However, primary viruses isolated from infected individuals are more refractory to neutralization
Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery.: J Virol. 1998 Dec;72(12):9873-80. Unique Identifier : AIDSLINE MED/99030895; Zufferey R; Dull T; Mandel RJ; Bukovsky A; Quiroz D; Naldini L; Trono D; Department of Genetics and Microbiology, University of Geneva; Medical School, Geneva, Switzerland.; In vivo transduction of nondividing cells by human immunodeficiency virus type 1 (HIV-1)-based vectors results in transgene expression that is stable over several months. However, the use of HIV-1 vectors raises concerns about their safety. Here we describe a self-inactivating HIV-1 vector with a 400-nucleotide deleti
Tat-associated kinase, TAK, activity is regulated by distinct mechanisms in peripheral blood lymphocytes and promonocytic cell lines.: J Virol. 1998 Dec;72(12):9881-8. Unique Identifier : AIDSLINE MED/99030896; Herrmann CH; Carroll RG; Wei P; Jones KA; Rice AP; Division of Molecular Virology, Baylor College of Medicine,; Houston, Texas 77030, USA. hermann@bcm.tmc.edu; TAK, a multisubunit cellular protein kinase that specifically associates with the human immunodeficiency virus Tat proteins and hyperphosphorylates the carboxyl-terminal domain of RNA polymerase II, is a cofactor for Tat and mediates its transactivation function. The catalytic subunit of TAK has been identified as cyc
Protective role of the virus-specific immune response for development of severe neurologic signs in simian immunodeficiency virus-infected macaques.: Unique Identifier : AIDSLINE MED/99030903; Sopper S; Sauer U; Hemm S; Demuth M; Muller J; Stahl-Hennig C; Hunsmann G; ter Meulen V; Dorries R; Institut fur Virologie und Immunbiologie,; Julius-Maximilians-Universitat, Wurzburg, Germany.; sopper@vim.uni-wuerzburg.de; The pathogenesis of human immunodeficiency virus-associated motor and cognitive disorders is poorly understood. In this context both a protective and a harmful role of the immune system has been discussed. This question was addressed in the present study by correlating the occurrence of neurologic disease in simian im
Host range and interference studies of three classes of pig endogenous retrovirus.: J Virol. 1998 Dec;72(12):9986-91. Unique Identifier : AIDSLINE MED/99030908; Takeuchi Y; Patience C; Magre S; Weiss RA; Banerjee PT; Le Tissier P; Stoye JP; Chester Beatty Laboratories, The Institute of Cancer Research,; London SW3 6JB, United Kingdom. yasuhiro@icr.ac.uk; Recent interest in the use of porcine organs, tissues, and cells for xenotransplantation to humans has highlighted the need to characterize the properties of pig endogenous retroviruses (PERVs). Analysis of a variety of pig cells allowed us to isolate and identify three classes of infectious type C endogenous retrovir
Rapid HIV screening during labor [letter]: JAMA. 1998 Nov 18;280(19):1664. Unique Identifier : AIDSLINE MED/99048836; Balano K; Beckerman K; Ng V
Home sample collection tests for HIV infection.: JAMA. 1998 Nov 18;280(19):1699-701. Unique Identifier : AIDSLINE MED/99048843; Branson BM; National Center for HIV, STD, and TB Prevention, Centers for; Disease Control and Prevention, Atlanta, GA 30333, USA.; BMB2@cdc.gov; CONTEXT: Home sample collection (HSC) tests allow persons to test themselves for human immunodeficiency virus (HIV) infection at home without medical supervision. Characterizing the use of such tests can help assess their potential effect on public health efforts to prevent and control HIV. OBJECTIVE: To describe use
From the Centers for Disease Control and Prevention. Use of short-course tuberculosis preventive therapy regimens in HIV-seronegative persons.: JAMA. 1998 Nov 25;280(20):1736. Unique Identifier : AIDSLINE MED/99057070
Improving patient compliance with HIV treatment regimens [letter]: JAMA. 1998 Nov 25;280(20):1745-6. Unique Identifier : AIDSLINE MED/99057081; Ungvarski PJ
Postexposure prophylaxis after nonoccupational HIV exposure: clinical, ethical, and policy considerations.: Unique Identifier : AIDSLINE MED/99057087; Lurie P; Miller S; Hecht F; Chesney M; Lo B; Center for AIDS Prevention Studies, University of California, San; Francisco, USA.; In the wake of recent breakthroughs in antiviral therapies and Centers for Disease Control and Prevention (CDC) recommendations advocating occupational postexposure prophylaxis (PEP), health care workers are increasingly receiving inquiries about PEP following exposures to the human immunodeficiency virus (HIV) throug
Global perspective from International AIDS Society president Mark Wainberg [interview by Dennis Blakesley]: JAMA. 1998 Dec 2;280(21):1811, 1813-4. Unique Identifier : AIDSLINE MED/99061216; Wainberg MA
An HIV-resistant allele is exceptionally frequent in New Guinean highlanders [letter]: JAMA. 1998 Dec 2;280(21):1830. Unique Identifier : AIDSLINE MED/99061233; Su B; Chakraborty R; Jin L; Xiao J; Lu D
Testosterone replacement therapy for HIV-related wasting: abstract and commentary.: JAMA. 1998 Dec 9;280(22):1959-60. Unique Identifier : AIDSLINE MED/99066810; Dieterich DT; Department of Medicine, New York University School of Medicine,; New York, USA.
A new HIV-1 group: abstract and commentary.: JAMA. 1998 Dec 9;280(22):1960. Unique Identifier : AIDSLINE MED/99066811; Delwart E; Aaron Diamond AIDS Research Center, New York, NY, USA.
Knowledge, attitude and behaviour towards AIDS among educated youth in Lahore, Pakistan.: JPMA J Pak Med Assoc. 1998 Jun;48(6):179-82. Unique Identifier : AIDSLINE MED/99031534; Raza MI; Afifi A; Choudhry AJ; Khan HI; Punjab AIDS Prevention and Control Program, Lahore.; OBJECTIVE: To assess the knowledge, attitude and behaviour regarding AIDS among educated young people in Lahore, Pakistan . METHODS: An anonymous survey of 733 males and 355 females was carried out using structured questionnaire among educated youth, selected randomly from non-med
[HIV-infection in St. Petersburg]: Klin Med (Mosk). 1998;76(9):57-9. Unique Identifier : AIDSLINE MED/99038819; Rakhmanova AG; Prigozhina VK; Popova IA; Khaldeeva NA; Sizova NV; Giaurgieva OKh; Volkova GV; Romanova EI
[Visceral leishmaniasis and HIV infection in differential diagnosis of fever conditions]: Klin Med (Mosk). 1998;76(9):68-9. Unique Identifier : AIDSLINE MED/99038822; Rugol' LV; Lobanova LI; Ageenko TA
Correspondence re: Immunophenotypic characterization of SIV-infected dendritic cells in the cervix, vagina, and draining lymph nodes of rhesus monkeys, by Hu J, Pope M, Brown C, O'Doherty U, and Miller CJ (Lab Invest 1998;78:435-451) [letter]: Lab Invest. 1998 Nov;78(11):1343-4. Unique Identifier : AIDSLINE MED/99054345; Nuovo M
The impact of soccer training on the immune system.: J Sports Med Phys Fitness. 1998 Sep;38(3):258-61. Unique Identifier : AIDSLINE MED/99048527; Rebelo AN; Candeias JR; Fraga MM; Duarte JA; Soares JM; Magalhaes C; Torrinha JA; Faculty of Sport Sciences, University of Porto, Portugal.; OBJECTIVE: The aim of this study was to evaluate whether the level of some immune markers changed in soccer players during pre-season and during playing-season. DESIGN: An observational study for one soccer season (one year). SETTING: Professional soccer players. PARTICIPANTS: Thirteen professional soccer players (age
HHV-8 infection is specific for cell lines derived from primary effusion (body cavity-based) lymphomas.: Leukemia. 1998 Nov;12(11):1806-9. Unique Identifier : AIDSLINE MED/99039563; Uphoff CC; Carbone A; Gaidano G; Drexler HG; DSMZ-German Collection of Microorganisms and Cell Cultures,; Department of Human and Animal Cell Cultures, Braunschweig,; Germany.; Human herpes virus 8 (HHV-8; or KSHV, Kaposi s sarcoma-associated herpes virus) is a gamma herpes virus with sequence homology to Epstein-Barr virus (EBV). It was first isolated from Kaposi s sarcoma tumor cells and subsequently from tumor cells and peripheral blood mononuclear cells from patients with primary effusio
Lack of evidence of an association between HHV-8 and multiple myeloma [letter]: Leukemia. 1998 Nov;12(11):1840-1. Unique Identifier : AIDSLINE MED/99039569; Bouscary D; Dupin N; Fichelson S; Grandadam M; Fontenay-Roupie M; Marcelin AG; Blanche P; Picard F; Freyssinier JM; Ravaud P; Dreyfus F; Calvez V
Staphylococcus aureus meningitis in a patient with acquired immunodeficiency syndrome.: Mayo Clin Proc. 1998 Nov;73(11):1083-4. Unique Identifier : AIDSLINE MED/99035405; Miller LG; Mathisen GE; Chang S; Division of Infectious Diseases, UCLA Medical Center, Los; Angeles, California, USA.; Meningitis due to Staphylococcus aureus is well described but uncommon. Most cases arise as a complication of neurosurgical interventions or head trauma, although some arise spontaneously. To our knowledge, no case of S. aureus meningitis has been previously reported in a person with the acquired immunodeficiency synd
Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study.: Mech Ageing Dev. 1998 May 15;102(2-3):187-98. Unique Identifier : AIDSLINE MED/98385605; Wikby A; Maxson P; Olsson J; Johansson B; Ferguson FG; Department of Natural Science and Biomedicine, University College; of Health Sciences, Jonkoping, Sweden.; Results from a previous longitudinal study indicated that a combination of high CD8 and low CD4 percentages and poor T cell proliferation in peripheral blood lymphocytes was associated with higher mortality in a subgroup of a sample of very old Swedish individuals. The present study examined whether those results coul
[Risk of the development of dementia after interruption of zidovudine treatment]: Med Clin (Barc). 1998 Sep 26;111(9):325-8. Unique Identifier : AIDSLINE MED/99028228; Teira R; Uriarte E; Munoz J; Uterga JM; Sadaba F; Zubero Z; Santamaria JM; Servicio de Medicina Interna, Hospital de Basurto, Bilbao.; BACKGROUND: Epidemiologic data suggest that zidovudine (ZDV) could prevent the AIDS dementia complex (ADC), but this hypothesis has been specifically studied. PATIENTS AND METHODS: We have reviewed the medical records of all patients with human immunodeficiency virus (HIV) infectio
[Balint's syndrome secondary to progressive multifocal leukoencephalopathy in a patient with acquired immunodeficiency syndrome (letter)]: Med Clin (Barc). 1998 Sep 26;111(9):357. Unique Identifier : AIDSLINE MED/99028235; Paytubi Gari C; Lopez-Balaguer JM; Balmana J; Cadafalch J
Sex differences in HIV-1 viral load and progression to AIDS.: Lancet. 1998 Nov 7;352(9139):1510-4. Unique Identifier : AIDSLINE MED/99036185; Farzadegan H; Hoover DR; Astemborski J; Lyles CM; Margolick JB; Markham RB; Quinn TC; Vlahov D; Department of Epidemiology, Johns Hopkins School of Hygiene and; Public Health, Baltimore, MD 21205, USA. hfarzade@jhsph.edu; BACKGROUND: Plasma HIV-1 RNA measurements are used for initiation of antiretroviral treatments. Whether the viral-load association with prognosis is similar in women and men is unknown. METHODS: We studied 812 specimens from 650 injection-drug users (IDUs) participating in a continuous observational study of patients
Nosocomial child-to-child transmission of HIV [letter]: Lancet. 1998 Nov 7;352(9139):1520. Unique Identifier : AIDSLINE MED/99036189; Nielsen H; Rosthoj S; Machuca R; Nielsen C; Smith E
US bill aids HIV-1-infected haemophiliacs [news]: Lancet. 1998 Nov 14;352(9140):1610. Unique Identifier : AIDSLINE MED/99057254; Rovner J
Late postnatal mother-to-child transmission of HIV-1 [letter]: Lancet. 1998 Nov 14;352(9140):1630. Unique Identifier : AIDSLINE MED/99057268; Glynn JR; Rodrigues L
Changing patterns of mortality across Europe in patients infected with HIV-1. EuroSIDA Study Group.: Lancet. 1998 Nov 28;352(9142):1725-30. Unique Identifier : AIDSLINE MED/99063093; Mocroft A; Vella S; Benfield TL; Chiesi A; Miller V; Gargalianos P; d'Arminio Monforte A; Yust I; Bruun JN; Phillips AN; Lundgren JD; Royal Free Centre for HIV Medicine and Department of Primary Care; and Population Sciences, Royal Free and University College; Medical School, University College London, UK. amanda@rfhsm.ac.uk; BACKGROUND: The introduction of combination antiretroviral therapy and protease inhibitors has led to reports of falling mortality rates among people infected with HIV-1. We examined the change in these mortality rates of HIV-1-infected patients across Europe during
Fatal interaction between ritonavir and MDMA [letter]: Lancet. 1998 Nov 28;352(9142):1751-2. Unique Identifier : AIDSLINE MED/99063100; Henry JA; Hill IR
Reporting of safety data from randomised trials [letter]: Lancet. 1998 Nov 28;352(9142):1752-3. Unique Identifier : AIDSLINE MED/99063101; Ioannidis JP; Contopoulos-Ioannidis DG
Indinavir concentrations in hair from patients receiving highly active antiretroviral therapy [letter]: Lancet. 1998 Nov 28;352(9142):1757-8. Unique Identifier : AIDSLINE MED/99063107; Bernard L; Peytavin G; Vuagnat A; de Truchis P; Perronne C
Bad news for the young in AIDS epidemic update [news]: Lancet. 1998 Nov 28;352(9142):1760. Unique Identifier : AIDSLINE MED/99063110; Bradbury J
Medical confidentiality broken to stop marriage of man infected with HIV [news]: Lancet. 1998 Nov 28;352(9142):1764. Unique Identifier : AIDSLINE MED/99063113; Kumar S
Lipid lowering therapy in patients with HIV infection [letter]: Lancet. 1998 Nov 28;352(9142):1782. Unique Identifier : AIDSLINE MED/99063122; Wierzbicki AS; Reynolds TM; Crook MA; Tatler J; Peters BS
Lipid lowering therapy in patients with HIV infection [letter]: Lancet. 1998 Nov 28;352(9142):1782-3. Unique Identifier : AIDSLINE MED/99063123; McBride M; Chin MT; Lee SM; Kelly B
Experimental leprosy in rhesus monkeys: transmission, susceptibility, clinical and immunological findings.: Lepr Rev. 1998 Sep;69(3):235-45. Unique Identifier : AIDSLINE MED/99022721; Gormus BJ; Xu K; Baskin GB; Martin LN; Bohm RP Jr; Blanchard JL; Mack PA; Ratterree MS; Meyers WM; Walsh GP; Department of Microbiology, Pathology, Tulane Regional Primate; Research Center, Covington, LA 70433, USA.; A total of 46 Rhesus monkeys (RM) was inoculated with Mycobacterium leprae (ML) and followed clinically and immunologically for extended periods. Twenty-one (45.7%) of the RM developed leprosy spanning the known leprosy spectrum, with six of 21 (28.6%) having disease in the borderline lepromatous to lepromatous area o
Use of combination antiretroviral therapy in pregnant women with HIV disease.: MCN Am J Matern Child Nurs. 1998 Nov-Dec;23(6):307-12; quiz 313. Unique Identifier : AIDSLINE MED/99036957; Newshan G; Hoyt MJ; St. Vincent's Hospital & Medical Center, New York, New York; 10011, USA.; Important advances in human immunodeficiency virus (HIV) medicine have brought about numerous changes in the clinical care of HIV-infected individuals. The availability of protease inhibitors to treat HIV infection, the introduction of HIV-RNA polymerase chain react
[Epidemiologic and clinical features of HIV-2 infection in Abidjan, Ivory Coast (letter)]: Med Trop (Mars). 1998;58(2):204-5. Unique Identifier : AIDSLINE MED/99007815; Eholie SP; Ehui E; Aoussi E; Kakou A; Assemien PA; Bissagnene E; Kadio A
Conservation of cytotoxic T lymphocyte (CTL) epitopes as a host strategy to constrain parasite adaptation: evidence from the nef gene of human immunodeficiency virus 1 (HIV-1).: Unique Identifier : AIDSLINE MED/99003700; da Silva J; Hughes AL; Host cytotoxic T lymphocytes (CTLs) that recognize specific viral peptides (epitopes) are thought to provide the most effective control of viral replication and spread. However, viruses may escape this recognition through mutations in CTL epitopes. We tested the hypothesis that, as an adaptation on the part of the hos
"You've gotta have HAART" [editorial; comment]: Med J Aust. 1998 Nov 2;169(9):456-7. Unique Identifier : AIDSLINE MED/99064361; Stewart GJ
HIV disease progression in Australia in the time of combination antiretroviral therapies [see comments]: Med J Aust. 1998 Nov 2;169(9):469-72. Unique Identifier : AIDSLINE MED/99064364; Correll PK; Law MG; McDonald AM; Cooper DA; Kaldor JM; National Centre in HIV Epidemiology and Clinical Research,; Sydney, NSW. pcorrell@nchecr.unsw.edu.au; OBJECTIVE: To examine the effect of recent developments in antiretroviral therapy on HIV disease progression and survival. DESIGN: Retrospective cohort study. PARTICIPANTS AND SETTING: Two cohorts of people with HIV were defined retrospectively from the records of a large immunology laboratory. The first cohort were s
Exacerbation of the inflammatory response to Mycobacterium tuberculosis after antiretroviral therapy.: Med J Aust. 1998 Nov 2;169(9):473-4. Unique Identifier : AIDSLINE MED/99064365; John M; French MA; Department of Clinical Immunology, Royal Perth Hospital, WA.; martfren@rph.health.wa.gov.au; A patient with HIV infection was successfully treated for pulmonary tuberculosis, but pulmonary inflammation and lymphadenitis worsened dramatically after subsequent combination antiretroviral therapy. As this relapse coincided with development of a strong delayed-type hypersensitivity response to tuberculin and impro
[Perinatal infection with the human immunodeficiency virus]: Unique Identifier : AIDSLINE MED/98441802; Milosevic S; INTRODUCTION: HIV infection, eventually resulting in AIDS, represents an important problem of the present days, whereas statistical parameters corresponding with the incidence of its manifestations and lethal outcome deserve great attention and cause anxieity of both general population and medical workers of all profi
[Agranulocytosis as a complication of acute infectious mononucleosis]: Med Pregl. 1998 Jul-Aug;51(7-8):355-8. Unique Identifier : AIDSLINE MED/98441808; Brkic S; Aleksic-Dordevic M; Belic A; Jovanovic J; Bogdanovic M; Klinika za infektivne i kozno-venericne bolesti, Medicinski; fakultet, Novi Sad.; INTRODUCTION: Acute infections mononucleosis is the most common clinical manifestation of primary Epstein-Barr virus (EBV) infection occurring during adolescence. It is a benign lymphoproliferative, usually self-limiting disease. Complications are relatively rare, but they may occur, especially hematological. Most com
Risks for HIV infection among persons residing in rural areas and small cities--selected sites, southern United States, 1995-1996.: MMWR Morb Mortal Wkly Rep. 1998 Nov 20;47(45):974-8. Unique Identifier : AIDSLINE MED/99057489; The southern region of the United States accounts for the largest proportion (34%) of the 641,086 acquired immunodeficiency syndrome (AIDS) cases reported through 1997 and for 54% of the 58,689 AIDS cases among persons residing in rural areas (CDC, unpublished data, 1998). This report
Enhanced 9-(2-phosphonylmethoxyethyl)adenine secretion by a specific, indomethacin-sensitive efflux pump in a mutant 9-(2-phosphonylmethoxyethyl)adenine-resistant human erythroleukemia K562 cell line.: Mol Pharmacol. 1998 Nov;54(5):907-17. Unique Identifier : AIDSLINE MED/99021726; Hatse S; De Clercq E; Balzarini J; Laboratory of Virology and Experimental Chemotherapy, Rega; Institute for Medical Research, Katholieke Universiteit Leuven,; B-3000 Leuven, Belgium.; We have investigated the molecular basis of the 100-fold resistance of mutant human erythroleukemia K562/PMEA-1 cells to the antiproliferative potential of 9-(2-phosphonylmethoxyethyl)adenine (PMEA). Upon exposure to high PMEA concentrations, comparable intracellular PMEA levels were initially observed in mutant K562/
[HIV-1 proteinase mutant with an altered region of the active center]: Mol Biol (Mosk). 1998 Jul-Aug;32(4):678-85. Unique Identifier : AIDSLINE MED/99001753; Dergousova NI; Rumsh LD; Andreeva NS
[Analysis of the immunologic heterogeneity of HIV-1: I. "Arginine-glutamine trigger" in the fourth position of the central tetrapeptide of the V3 loop of gp120]: Unique Identifier : AIDSLINE MED/99001757; Shchelkanov MIu; Iaroslavtseva NG; Iudin AN; Eremin VF; Pyzhova NS; Semiletov IuA; Abelian AV; Titov LP; Karamov EV
[Analysis of the immunologic heterogeneity of HIV-1. II. Effect of amino acid residues, flanking the C-terminus of the central: Unique Identifier : AIDSLINE MED/99001758
Structural similarity of two T cell signaling regulators suggests a conserved and interactive mechanism of immunosuppression.: Unique Identifier : AIDSLINE MED/99053291; Vieira A; National Public Health Institute, KTL-BIOS, Helsinki, Finland.; A primary structural element is identified which is present in the Nef protein of immunodeficiency viruses and in the cytoplasmic domain of a regulatory T cell protein, CTLA-4. In both proteins, conserved residues that lie within this element have been shown to be important for the regulation of cellular signaling and
Feline immunodeficiency virus associated myopathy in the adult cat.: Muscle Nerve. 1998 Dec;21(12):1680-5. Unique Identifier : AIDSLINE MED/99057203; Podell M; Chen E; Shelton GD; Department of Veterinary Clinical Sciences, College of Veterinary; Medicine, Comprehensive Cancer Center, The Ohio State University,; Columbus 43210, USA.; Human immunodeficiency virus (HIV-1) associated myopathy can be a debilitating disease in humans, leading to weakness, myalgia, and muscle wasting. Subclinical neuromuscular involvement is also common. A range of histologic lesions have been described in both forms that include both inflammatory and degenerative chang
A controlled trial of itraconazole to prevent relapse of Penicillium marneffei infection in patients infected with the human immunodeficiency virus.: N Engl J Med. 1998 Dec 10;339(24):1739-43. Unique Identifier : AIDSLINE MED/99049886; Supparatpinyo K; Perriens J; Nelson KE; Sirisanthana T; Department of Medicine, Chiang Mai University, Thailand.; BACKGROUND: In Southeast Asia, disseminated infection with Penicillium marneffei is common among patients with human immunodeficiency virus (HIV) infection. Even after successful primary treatment, the relapse rate for this potentially fatal systemic fungal infection is about 50 percent. METHODS: We conducted a double
Lamivudine for chronic hepatitis B [letter]: N Engl J Med. 1998 Dec 10;339(24):1786-7. Unique Identifier : AIDSLINE MED/99049899; Bernasconi E; Battegay M
Human immunodeficiency virus type 1 in the semen of men receiving highly active antiretroviral therapy [see comments]: N Engl J Med. 1998 Dec 17;339(25):1803-9. Unique Identifier : AIDSLINE MED/99061023; Zhang H; Dornadula G; Beumont M; Livornese L Jr; Van Uitert B; Henning K; Pomerantz RJ; Center for Human Virology, Department of Medicine, Jefferson; Medical College, Thomas Jefferson University, Philadelphia, PA; 19107, USA.; BACKGROUND: Highly active antiretroviral therapy can effectively decrease the levels of human immunodeficiency virus type 1 (HIV-1) virions in peripheral plasma and seminal fluid of infected men. Whether the genital tract of HIV-1-infected men who are receiving highly active antiretroviral therapy and who have no dete
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 38-1998. A 19-year-old man with the acquired immunodeficiency syndrome and persistent fever [clinical conference]: N Engl J Med. 1998 Dec 17;339(25):1835-43. Unique Identifier : AIDSLINE MED/99061029
Potential for the transmission of HIV-1 despite highly active antiretroviral therapy [editorial; comment]: N Engl J Med. 1998 Dec 17;339(25):1846-8. Unique Identifier : AIDSLINE MED/99061031; Haase AT; Schacker TW
India agrees to conduct AIDS vaccine trials [news]: Nature. 1998 Nov 12;396(6707):102. Unique Identifier : AIDSLINE MED/99039484; Jayaraman KS
AIDS and money. Where do we go from here?: N C Med J. 1998 Nov-Dec;59(6):344-7. Unique Identifier : AIDSLINE MED/99046060; Engel J; Department of Medicine, East Carolina University School of; Medicine, Greenville 27858, USA.
Role-modeling experience improves nursing students' attitudes toward people living with AIDS.: Nursingconnections. 1998 Spring;11(1):41-9. Unique Identifier : AIDSLINE MED/98308350; Grossman S; Wheeler K; Lippman D; Fairfield University School of Nursing, CT, USA.; Two groups of student nurses were given on AIDS Knowledge/Attitudes survey before different clinical experiences. Group One worked with nurses experienced in the care of persons living with AIDS (PLWA) on a high-acuity unit with many AIDS patients. The other group were precepted on a acute-care unit with no AIDS patie
Relationships among HIV risk beliefs, attitudes, and behaviors in sexually active, seronegative gay men.: Nursingconnections. 1998 Spring;11(1):5-24. Unique Identifier : AIDSLINE MED/98308346; Phillips KD; Sowell RL; Misener TR; University of South Carolina, Columbia, USA.; Safer-sex guidelines established during the early days of the HIV/AIDS epidemic have undergone very little revision despite some controversy. Although these guidelines have been widely disseminated in the gay community, many gay men continue to engage in behaviors that are believed to put them at high risk for transmi
[Infection with Mycobacterium genavense in 2 HIV-seropositive patients in Amsterdam (letter)]: Ned Tijdschr Geneeskd. 1998 Jul 11;142(28):1629. Unique Identifier : AIDSLINE MED/98436342; van Ginneken EE; Koopmans PP
HIV infection presenting with Fournier's gangrene.: Neth J Med. 1998 Oct;53(4):168-71. Unique Identifier : AIDSLINE MED/99043083; Roca B; Cunat E; Simon E; Infectious Diseases Unit, Hospital General of Castellon, Spain.; brocav@meditex.es; Fournier s gangrene represents an acute severe necrotizing inflammatory process affecting the scrotum and penis. We report the case of a patient with Fournier s gangrene as the presenting sign of HIV infection. The process began with balanitis and rapidly destroyed the penis. Aggressive medical and surgical management
Evidence of hepatitis C virus passage across dialysis membrane.: Nephron. 1998 Oct;80(2):194-6. Unique Identifier : AIDSLINE MED/98409582; Valtuille R; Fernandez JL; Berridi J; Moretto H; del Pino N; Rendo P; Lef L; Terapia Sustitutiva Renal, Monte Grande, Buenos Aires, and Bio; Sidus, Buenos Aires, Argentina.; The passage of hepatitis C virus (HCV) across the dialysis membrane is a controversial issue. We performed a study applying extreme conditions of permeability to the dialysis membrane and avoiding the use of heparin and dialysis bath that might interfere with polymerase chain reaction (PCR) results. We obtained sample
Lack of an epidemiologic link between Kaposi's sarcoma and CNS lymphoma in patients with AIDS [letter]: Neurology. 1998 Nov;51(5):1513. Unique Identifier : AIDSLINE MED/99034214; Buskin S; Diamond C; Hopkins S
Use of surrogate markers for drugs of military importance.: Mil Med. 1998 Nov;163(11):743-6. Unique Identifier : AIDSLINE MED/99036967; Marino MT; Department of Pharmacology, Walter Reed Army Institute of; Research, Washington, DC 20307-5100, USA.; In the future, U.S. military forces will be faced with opposing forces that have chemical and biological weapon capabilities. Although drugs used against these agents would be an ideal solution to protecting soldiers, the ability to test their efficacy in humans is limited by several ethical and technical problems: (1
Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.: Unique Identifier : AIDSLINE MED/98417011; Schroder HC; Perovic S; Kavsan V; Ushijima H; Muller WE; Institut fur Physiologische Chemie, Abteilung Angewandte; Molekularbiologie, Universitat, Mainz, Germany.; In vitro experiments revealed that the scrapie prion protein, PrP(Sc), as well as the PrP fragment PrP106-126, and the HIV-1 coat protein gp120 induce apoptosis of rat cortical neurons. The toxic effect displayed by PrP and gp120 could be blocked by NMDA receptor antagonists. Treatment of neuronal cells with PrP106-12
Treating HIV disease: hope on the horizon.: Nursing. 1998 Nov;28(11):34-9; quiz 40. Unique Identifier : AIDSLINE MED/99073264; Kirsten VL; Whipple B; New Latitudes, Inc., Philadelphia, Pa., USA.
Nursing and HIV: changing issues in Ohio.: Ohio Nurses Rev. 1998 Feb;73(2):15. Unique Identifier : AIDSLINE MED/98235130; Scholz J
The Th1 to Th2 shift induced by Schistosoma mansoni does not exacerbate murine aids (MAIDS).: Parasite Immunol. 1998 Oct;20(10):497-501. Unique Identifier : AIDSLINE MED/99016140; Lacroix C; Akarid K; Chau F; Sinet M; Verola O; Carbon C; Derouin F; INSERM U13, Hopital Bichat-Claude Bernard, Paris, France;; Laboratoire de Parasitologie-Mycologie.; Schistosoma mansoni infection in mice is associated with a switch from a Th1 to a Th2-type cytokine response. The role of Th1 and Th2 responses in immune dysregulations associated with AIDS and murine AIDS (MAIDS) is controversial, but a Th2 bias could be associated with disease progression, raising the hypothesis tha
New perspectives in the immunology of Echinococcus granulosus infection.: Parassitologia. 1997 Dec;39(4):275-7. Unique Identifier : AIDSLINE MED/99018887; Rigano R; Profumo E; Siracusano A; Laboratorio di Immunologia, Istituto Superiore di Sanita, Roma,; Italy.; This article reviews the role of cytokines and immunoglobulin isotypes in the clinical outcome of E. granulosus infection. The coexistence of elevated quantities of IFN-gamma, IL-4, IL-5, IL-6 and IL-10 observed in most of hydatid patients supports Th1 and Th2 cell activation in human hydatidosis. In particular, Th1 c
Immune response in a murine model of congenital toxoplasmosis: increased susceptibility of pregnant mice and transplacental passage of Toxoplasma gondii are type 2-dependent.: Parassitologia. 1997 Dec;39(4):279-83. Unique Identifier : AIDSLINE MED/99018888; Thouvenin M; Candolfi E; Villard O; Klein JP; Kien T; Institut de Parasitologie, Strasbourg, France.; We used a model of acquired toxoplasmosis to study the immune response in pregnant BALB/c mice (IL-4+/+) and in pregnant transgenic IL-4-deficient BALB/c mice (IL-4-/-) during acute toxoplasmosis. Female BALB/c mice were infected orally by 20 tissue cysts of the avirulent PRU strain of Toxoplasma gondii on day 11 of p
A PCR-RFLP method for the detection and species identification of human microsporidia.: Parassitologia. 1997 Dec;39(4):437-9. Unique Identifier : AIDSLINE MED/99018917; Sironi M; Bandi C; Novati S; Scaglia M; Istituto di Patologia Generale Veterinaria, Universita di; Milano, Italy.; From small subunit ribosomal RNA gene sequences, a pair of PCR primers were designed to amplify a portion of this gene from five species of microsporidia. The amplified fragments encompass polymorphic restriction sites for the Hphl enzyme, resulting in different restriction patterns in the different species. We tested
[Lymph node dissemination of a serious Pneumocystis carinii respiratory infection in AIDS: histopathological and ultrastructural aspects]: Pathologica. 1998 Aug;90(4):383-7. Unique Identifier : AIDSLINE MED/99009794; Manfredi R; Salfi N; Pasquinelli G; Chiodo F; Dipartimento di Medicina Clinica Specialistica e Sperimentale,; Universita di Bologna.; A case report of isolated lymph node extension of atypical respiratory Pneumocystis carinii infection which occurred in an HIV-infected patient undergoing aerosolized pentamidine prophylaxis is presented with its histopathological and ultrastructural features. AIDS-associated extrapulmonary and disseminated pneumocyst
[Human microsporidiosis: emergence of a new opportunistic microorganism in patients infected with the human immunodeficiency virus (HIV)]: Pathologica. 1998 Aug;90(4):412-3. Unique Identifier : AIDSLINE MED/99009800; Boldorini R; Tosoni A
Nutritional assessment for children who are HIV-infected.: Pediatr Nurs. 1998 Mar-Apr;24(2):137-41, 149. Unique Identifier : AIDSLINE MED/98362905; Deatrick JA; Lipman TH; Thurber F; Ash L; Carlino H; McKnight H; Rutstein RM; University of Pennsylvania School of Nursing, Philadelphia, USA.; Pathophysiologic, psychosocial, and economic considerations are important in nutritional assessment of infants and children who are HIV-infected. Nutritional assessment guidelines vary based on the child s circumstances. Specific assessment guidelines are proposed for (a) ongoing ambulatory care; (b) when growth decel
Ureteral obstruction secondary to indinavir in the pediatric HIV population.: Pediatr Radiol. 1998 Aug;28(8):627-9. Unique Identifier : AIDSLINE MED/98384425; Noble CB; Klein LT; Staiman VR; Neu N; Hensle TW; Berdon WE; Department of Radiology, Babies & Children's Hospital of New; York, 3959 Broadway, BHN 3-318, New York, NY 10032, USA.; Indinavir sulfate is a protease inhibitor used in the treatment of the human immunodeficiency virus (HIV). This case report describes the radiographic and urologic manifestations of indinavir urolithiasis in two pediatric patients with acquired immuno
Role of CCR5 chemokine receptor gene in vertical human immunodeficiency virus type 1 transmission and disease progression.: Pediatr Infect Dis J. 1998 Sep;17(9):847-9. Unique Identifier : AIDSLINE MED/98451060; Esposito S; Zehender G; Zuccotti GV; Vegni C; Galli L; Vecchi V; Agostino C; Rancilio L; De Maddalena C; Clerici M; Principi N; Paediatric Department IV, University of Milan, Italy.
Antiretroviral therapy and medical management of pediatric HIV infection and 1997 USPHS/IDSA report on the prevention of opportunistic infections in persons infected with human immunodeficiency virus.: Pediatrics. 1998 Oct;102(4 Pt 2):999-1085. Unique Identifier : AIDSLINE MED/99044230
[Beginning of the end of HIV? (editorial)]: Nord Med. 1998 Nov;113(9):286. Unique Identifier : AIDSLINE MED/99052476; Britton S
[New preventive possibilities in HIV infection]: Nord Med. 1998 Nov;113(9):287-9. Unique Identifier : AIDSLINE MED/99052477; Nielsen JO; Infektionsmedicinsk afdeling, Hvidovre Hospital.; The most important preventive measures against accidental HIV infection in health care are the education of personnel and the observance of routine procedures in everyday work. In this way, the accidental infection rate can be reduced by more than 50 per cent. Consistent registration of the causes of accidental infect
[Current treatment of HIV infection]: Nord Med. 1998 Nov;113(9):290-2, 296. Unique Identifier : AIDSLINE MED/99052478; Blaxhult A; Lidman K; Infektionskliniken, Danderyds Sjukhus.; The treatment of HIV infection in the industrialised countries has undergone manifest changes during the past decade. Since the advent of zidovudine in 1987, the first agent capable of delaying disease progression, several other nucleoside analogues have been introduced, though in retrospect the effect of these drugs
Mapping of a protein-RNA kissing hairpin interface: Rom and Tar-Tar*.: Nucleic Acids Res. 1998 Oct 15;26(20):4688-95. Unique Identifier : AIDSLINE MED/98428649; Comolli LR; Pelton JG; Tinoco I Jr; Department of Chemistry, University of California at Berkeley and; Structural Biology Department, Physical Biosciences Division,; Lawrence Berkeley National Laboratory, Berkeley, CA 94720-1460,; USA.; An RNA kissing complex is formed by the association of two hairpins via base pairing of their complementary loops. This sense-antisense RNA motif is used in the regulation of many cellular processes, including Escherichia coli ColE1 plasmid copy number. The RNA one modulator protein (Rom) acts as a co-regulator of C
The effect of a social support boosting intervention on stress, coping, and social support in caregivers of children with HIV/AIDS [letter]: Nurs Res. 1998 Nov-Dec;47(6):307-8. Unique Identifier : AIDSLINE MED/99051149; Eldredge D
Progress towards controlling HIV-associated TB upsurge.: Nurs Times. 1998 Mar 18-24;94(11):54-5. Unique Identifier : AIDSLINE MED/98362873; Marais F; St Mary's NHS Trust, London.; One of the reasons for the global increase in the incidence of tuberculosis is its association with HIV. The significance of the link led to the development of a specialist service at St Mary s Hospital NHS Trust, London. The service supports people with HIV and TB, and monitors their treatment. This article describes
Leap of faith [interview by David Payne]: Nurs Times. 1998 Sep 23-29;94(38):14-5. Unique Identifier : AIDSLINE MED/99049996; Sims R
Case-control study of amphotericin B in a triglyceride fat emulsion versus conventional amphotericin B in patients with AIDS.: Pharmacotherapy. 1998 Sep-Oct;18(5):1087-92. Unique Identifier : AIDSLINE MED/98429287; Manfredi R; Chiodo F; Department of Clinical and Experimental Medicine, University of; Bologna, Italy.; We evaluated the efficacy and tolerability of amphotericin B triglyceride emulsion in 16 patients with acquired immunodeficiency syndrome-related candidal esophagitis and cryptococcosis, compared with standard amphotericin B in 24 patients. Compared with the conventional formulation, the fat emulsion was administered
[Erythropoietin in the pathogenesis of anemia in patients with multiple myeloma]: Pol Arch Med Wewn. 1998 Mar;99(3):218-23. Unique Identifier : AIDSLINE MED/98433532; Rokicka-Piotrowicz M; Paluszewska M; Paszkowska M; Rakowska A; Wierzbicka E; Buras A; Kuratowska Z; Klinika Chorob Wewnetrznych i Hematologii AM w Warszawie.; Anemia is a common symptom in multiple myeloma (MM) patients but the pathogenesis of it is still unknown. The aim of the study was to explain the causes of anemia in MM patients. Peripheral blood count, bone marrow aspirate, iron and ferritin level, serum erythropoietin (EPO) level, T cell subsets and in vitro CFU-E c
Unusual diagnoses among violent patients.: Unique Identifier : AIDSLINE MED/98447922; Tardiff K; Department of Psychiatry, Cornell University Medical College, New; York, New York, USA.; Several medical disorders rarely cause violent behavior. When they do so, it is dramatic because the violence and other bizarre behaviors are not in keeping with the premorbid picture of the individual. Often, medical and neurologic symptoms are present, but occasionally psychiatric symptoms may present alone with the
Cellular uptake mechanism of amino acid ester prodrugs in Caco-2/hPEPT1 cells overexpressing a human peptide transporter.: Pharm Res. 1998 Sep;15(9):1382-6. Unique Identifier : AIDSLINE MED/98427320; Han HK; Oh DM; Amidon GL; College of Pharmacy, The University of Michigan, Ann Arbor; 48109-1065, USA.; PURPOSE: This study characterized the cellular uptake mechanism and hydrolysis of the amino acid ester prodrugs of nucleoside antiviral drugs in the transiently transfected Caco-2 cells overexpressing a human intestinal peptide transporter, hPEPT1 (Caco-2/hPEPT1 cells). METHODS: Amino acid ester prodrugs of
Hydrophobicity of HIV protease inhibitors by immobilized artificial membrane chromatography: application and significance to drug transport.: Pharm Res. 1998 Sep;15(9):1401-6. Unique Identifier : AIDSLINE MED/98427323; Stewart BH; Chung FY; Tait B; John C; Chan OH; Pharmacokinetics/Dynamics & Metabolism Department, Parke-Davis; Pharmaceutical Research Division, Warner-Lambert Company, Ann; Arbor, Michigan 48105, USA. barbra.stewart@wl.com; PURPOSE: The feasibility of using hydrophobicity measurements as screens for intracellular availability in T-cells or intestinal permeability in Caco-2 cells was examined. METHODS: T-cell experiments: Cells were counted, collected, then incubated with drug solution at 37 degrees C. At selected time intervals, uptake w
Characterization of three crystalline forms (VIII, XI, and XII) and the amorphous form (V) of delavirdine mesylate using 13C CP/MAS NMR.: Pharm Res. 1998 Sep;15(9):1425-33. Unique Identifier : AIDSLINE MED/98427327; Gao P; Pharmaceutical Development, Pharmacia & Upjohn, Kalamazoo,; Michigan 49001, USA. ping.gao@am.pnu.com; PURPOSE: The application of solid-state nuclear magnetic resonance (NMR) characterization of three crystalline forms (VIII, XI, XII) and the amorphous form V of delavirdine mesylate (DLV-M) is presented. METHODS: Conventional 13CCP (cross-polarization
[Incidental discovery of HTLV1 serology in recurrent strongyloidias: 2 cases (letter)]: Presse Med. 1998 Oct 31;27(33):1681. Unique Identifier : AIDSLINE MED/99051848; Botterel F; Cornet M; Bouree P
[The role of stavudine in antiretroviral therapy]: Presse Med. 1998 Oct 31;27(33):1708-9. Unique Identifier : AIDSLINE MED/99051856; Molina JM
[Hospital medical students: a population at risk for accidental exposure to blood]: Presse Med. 1998 Nov 7;27(34):1723-6. Unique Identifier : AIDSLINE MED/99052645; Keita-Perse O; Pradier C; Rosenthal E; Altare J; Cassuto JP; Dellamonica P; Centre d'Information et de Soins de l'Immunodeficience Humaine; (CISIH), Hopital l'Archet 1, Nice. episud@mail.azur.fr; OBJECTIVE: Infections transmitted by blood such as viral hepatitis B and C or human immunodeficiency virus (HIV) are a true threat to health care workers. As medical students are exposed to accidental contamination during their hospital activities, we conducted a survey among medical students in Nice
[Antiretroviral therapy of HIV infections. New recommendations by the International AIDS Society]: Presse Med. 1998 Nov 7;27(34):1739-41. Unique Identifier : AIDSLINE MED/99052654; Allouch H
[Apropos of antiretroviral therapy of HIV infection (interview by H. Allouch)]: Presse Med. 1998 Nov 7;27(34):1741-4. Unique Identifier : AIDSLINE MED/99052656; Sobel A
[Apropos of antiretroviral therapy of HIV infections (interview by H. Allouch)]: Presse Med. 1998 Nov 7;27(34):1741-4. Unique Identifier : AIDSLINE MED/99052655; Yeni P
Quantitative measurement of telomerase activity in lymphadenopathy: correlation with histologic features and human immunodeficiency virus-1 infection.: Mod Pathol. 1998 Oct;11(10):957-62. Unique Identifier : AIDSLINE MED/99010746; Strovel JW; Abruzzo LV; Highsmith WE; Stamberg J; Division of Human Genetics, University of Maryland Medical; System, Baltimore 21201, USA.; Telomerase is a ribonucleoprotein that uses its internal RNA component as a template for synthesis of telomeric DNA on the ends of chromosomes after each round of cell division. It is expressed in approximately 90% of all human cancers tested to date, as well as in most immortal cell lines. Recently, telomerase activi
Immunohistochemical analysis of mycosis fungoides on paraffin-embedded tissue sections.: Unique Identifier : AIDSLINE MED/99010750; Izban KF
Predicting structural effects in HIV-1 protease mutant complexes with flexible ligand docking and protein side-chain optimization.: Proteins. 1998 Nov 1;33(2):295-310. Unique Identifier : AIDSLINE MED/98451075; Schaffer L; Verkhivker GM; Agouron Pharmaceuticals, Inc., La Jolla, California 92037, USA.; We present a computational approach for predicting structures of ligand-protein complexes and analyzing binding energy landscapes that combines Monte Carlo simulated annealing technique to determine the ligand bound conformation with the dead-end elimination algorithm for side-chain optimization of the protein active
Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism.: Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13471-6. Unique Identifier : AIDSLINE MED/99030593; Meyer PR; Matsuura SE; So AG; Scott WA; Department of Biochemistry and Molecular Biology, University of; Miami, Miami, FL 33101, USA.; HIV-1 replication is inhibited by the incorporation of chain-terminating nucleotides at the 3 end of the growing DNA chain. Here we show a nucleotide-dependent reaction catalyzed by HIV-1 reverse transcriptase that can efficiently remove the chain-terminating residue, yielding an extendible primer terminus. Radioacti
lambda Rap protein is a structure-specific endonuclease involved in phage recombination.: Unique Identifier : AIDSLINE MED/99030599; Sharples GJ; Corbett LM; Graham IR; Bacteriophage lambda encodes a number of genes involved in the recombinational repair of DNA double-strand breaks. The product of one of these genes, rap, has been purified. Truncated Rap proteins that copurify with the full-length form are derived, at least in part, from a rho-dependent transcription terminator locat
HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter.: Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13519-24. Unique Identifier : AIDSLINE MED/99030601; Marzio G; Tyagi M; Gutierrez MI; Giacca M; Molecular Medicine Laboratory, International Centre for Genetic; Engineering and Biotechnology (ICGEB), Padriciano 99, 34012; Trieste, Italy.; In cells infected with HIV type 1 (HIV-1), the integrated viral promoter is present in a chromatin-bound conformation and is transcriptionally silent in the absence of stimulation. The HIV-1 Tat protein binds to a stem-loop structure at the 5 end of viral mRNA and relieves this inhibition by inducing a remodeling of
Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome.: Unique Identifier : AIDSLINE MED/99030644; Nichols KE; Harkin DP; Levitz S; Krainer M; Kolquist KA; Genovese C; Bernard A; Ferguson M; Zuo L; Snyder E; Buckler AJ; Wise C; Ashley J; Lovett M; Valentine MB; Look AT; Gerald W; Housman DE; Haber DA; X-linked lymphoproliferative syndrome (XLP) is an inherited immunodeficiency characterized by increased susceptibility to Epstein-Barr virus (EBV). In affected males, primary EBV infection leads to the uncontrolled proliferation of virus-containing B cells and reactive cytotoxic T cells, often culminating in the devel
Characteristics of virus-specific CD8(+) T cells in the liver during the control and resolution phases of influenza pneumonia.: Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13812-7. Unique Identifier : AIDSLINE MED/99030652; Belz GT; Altman JD; Doherty PC; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, TN 38105, USA.; Dissection of the primary and secondary response to an influenza A virus established that the liver contains a substantial population of CD8(+) T cells specific for the immunodominant epitope formed by H-2Db and the influenza virus nucleoprotein peptide fragment NP366-374 (DbNP366). The numbers of CD8(+) DbNP366(+) ce
T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6.: Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13823-8. Unique Identifier : AIDSLINE MED/99030654; Dent AL; Hu-Li J; Paul WE; Staudt LM; Metabolism Branch, National Cancer Institute, National Institutes; of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.; An important signaling pathway for the differentiation of T helper type 2 (TH2) cells from uncommitted CD4 T cell precursors is activation of the STAT6 transcription factor by interleukin 4 (IL-4). The protooncogene BCL-6 is also involved in TH2 differentiation, as BCL-6 -/- mice develop an inflammation of the heart a
Peptide inhibitors of HIV-1 protease and viral infection of peripheral blood lymphocytes based on HIV-1 Vif.: Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13865-8. Unique Identifier : AIDSLINE MED/99030661; Potash MJ; Bentsman G; Muir T; Krachmarov C; Sova P; Volsky DJ; Molecular Virology Laboratory, St. Luke's-Roosevelt Hospital; Center, Columbia University, New York, NY 10019, USA.; We recently reported that HIV-1 Vif (virion infectivity factor) inhibits HIV-1 protease in vitro and in bacteria, suggesting that it may serve as the basis for the design of new protease inhibitors and treatment for HIV-1 infection. To evaluate this possibility, we
Hybrid Ty1/HIV-1 elements used to detect inhibitors and monitor the activity of HIV-1 reverse transcriptase.: Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13905-10. Unique Identifier : AIDSLINE MED/99030668; Nissley DV; Boyer PL; Garfinkel DJ; Hughes SH; Strathern JN; Gene Regulation and Chromosome Biology Laboratory, National; Cancer Institute-Frederick Cancer Research and Development; Center, ABL-Basic Research Program, Frederick, MD 21702-1201,; USA. nissley@ncifcrf.gov; We previously demonstrated that hybrid retrotransposons composed of the yeast Ty1 element and the reverse transcriptase (RT) of HIV-1 are active in the yeast Saccharomyces cerevisiae. The RT activity of these hybrid Ty1/HIV-1 (his3AI/AIDS RT; HART) elements can be monitored by using a simple genetic assay. HART elemen
[Tuberculosis: a forgotten plague of mankind reported to be returning (news)]: Pharm Unserer Zeit. 1998 Sep;27(5):233-4. Unique Identifier : AIDSLINE MED/99016851
Clozapine treatment of HIV-associated psychosis--too much bone marrow toxicity?: Pharmacopsychiatry. 1998 Jul;31(4):156-7. Unique Identifier : AIDSLINE MED/98425848; Dettling M; Muller-Oerlinghausen B; Britsch P; Department of Psychiatry, Freie Universitat Berlin, Germany.
Betulinic acid inhibits aminopeptidase N activity [letter]: Planta Med. 1998 Oct;64(7):655-7. Unique Identifier : AIDSLINE MED/99027967; Melzig MF; Bormann H; The triterpene betulinic acid inhibits the activity of aminopeptidase N (EC 3.4.11.2) in a dose-dependent manner. An IC50 of 7.3 +/- 1.4 microM was determined for betulinic acid. This inhibitory activity is higher than that of bestatin (IC50 = 16.9 +/- 4.1 microM), a well known inhibitor of this enzyme. The finding s
Suicidal ideation, suicide attempts, and HIV infection.: Psychosomatics. 1998 Sep-Oct;39(5):405-15. Unique Identifier : AIDSLINE MED/98448836; Kelly B; Raphael B; Judd F; Perdices M; Kernutt G; Burnett P; Dunne M; Burrows G; Department of Psychiatry, University of Queensland, Brisbane,; Australia.; A cross-sectional study was performed to investigate the prevalence and predictors of suicidal ideation and past suicide attempt in an Australian sample of human immunodeficiency virus (HIV)-positive and HIV-negative homosexual and bisexual men. Sixty-five HIV-negative and 164 HIV-positive men participated. A suicidal
Family demography in a remote rural community in Zambia.: Public Health. 1998 Sep;112(5):313-6. Unique Identifier : AIDSLINE MED/99025059; Ashworth TG; Kasanka Trust, London.; A community survey was conducted in a remote rural area of Zambia by The Kasanka Trust whose aims in running a National Park are to include aid to the community living around its borders. Selected results have been extracted from a general report by the Kasanka Trust, including awa
The role of tumour necrosis factor, interleukin 6, interferon-gamma and inducible nitric oxide synthase in the development and pathology of the nervous system.: Prog Neurobiol. 1998 Oct;56(3):307-40. Unique Identifier : AIDSLINE MED/98442378; Munoz-Fernandez MA; Fresno M; Division of Immunology, Hospital General Universitario Gregorio; Maranon, Madrid, Spain.; Proinflammatory cytokines, tumour necrosis factor (TNF)-alpha, interferon (IFN)-gamma and interleukin (IL)-6, have multiple effects in the central nervous system (CNS) not strictly cytotoxic being involved in controlling neuronal and glial activation, proliferation, differentiation and survival, thus influencing neuro
Integrating women's perspectives on prenatal human immunodeficiency virus screening: toward a socially just policy.: Res Nurs Health. 1998 Dec;21(6):499-509. Unique Identifier : AIDSLINE MED/99053530; Mawn B; University of Massachusetts Lowell College of Health Professions,; Department of Nursing, 01854, USA.; The purpose of this study was to include the voices of laywomen at risk for or living with human immunodeficiency virus (HIV) in the ongoing debate on prenatal and newborn HIV screening. A phenomenological approach based on Moustakas s heuristic model was used in order to explore women s lived experience. The investig
[Value of magnetic resonance in the diagnostic definition of neurotoxoplasmosis and in the assessment of the response to pharmacological treatment]: Radiol Med (Torino). 1998 Jul-Aug;96(1-2):23-8. Unique Identifier : AIDSLINE MED/99037049; Sparacia G; Brancatelli G; Sarno C; De Maria M; Lagalla R; Filosto L; Istituto di Radiologia P. Cignolini, Universita degli Studi,; Palermo. sparacia@unipa.it; PURPOSE: We investigated the role of Magnetic Resonance Imaging (MRI) in the diagnosis of neurotoxoplasmosis and in the evaluation of drug treatment response. MATERIAL AND METHODS: Twenty-six AIDS patients (22 men and 4 women, mean age 26.7 years) with clinical suspicion of neurotoxoplasmosis were examined. A patient
[Diagnostic imaging of current pulmonary tuberculosis. Clinical significance of the presentation patterns and particular aspects in HIV-positive and HIV-negative subjects]: Radiol Med (Torino). 1998 Jul-Aug;96(1-2):55-61. Unique Identifier : AIDSLINE MED/99037054; Diotallevi P; Cristofaro M; Natale L; Scano M; Geraci S; Montella F; Serra G; Azienda Ospedaliera San Giovanni, Addolorata.; PURPOSE: We compared two groups of risk patients to try to identify different radiologic patterns in pulmonary tuberculosis. MATERIALS AND METHODS: 74 subjects, divided into two groups (HIV+:27; HIV-:47) were included since 1993. The patients were examined with chest X-ray (CXR) and CT. RESULTS: In the HIV+ group we o
Alcohol and the pancreas.: Recent Dev Alcohol. 1998;14:41-65. Unique Identifier : AIDSLINE MED/98424496; Schenker S; Montalvo R; Department of Medicine, University of Texas Health Science Center; at San Antonio 78284-7878, USA.; Alcoholic pancreatitis may be one of the most serious adverse consequences of alcohol abuse. Its diagnosis, as it has for many years, depends primarily on clinical acumen in interpreting properly the symptoms and signs of abdominal distress, buttressed by elevated pancreatic enzymes (amylase and lipase). More recently
[7 new cases of HIV-2 infection recognized in Madrid in 1996 and 1997]: Rev Clin Esp. 1998 Oct;198(10):660-4. Unique Identifier : AIDSLINE MED/99060444; Machuca A; Gutierrez M; Holguin A; Camba M; Belda J; Soriano V; Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos; III, Madrid.; The infection with human immunodeficiency virus type-2 (HIV-2) is endemic in Western Africa, where it is responsible for many of AIDS cases. In Spain , 72 cases with HIV-2 until December 1997 had been reported, mainly in African immigrants. Seven of these cases (4 males and 3 females
[Admissions and mortality in a HIV unit before and after protease inhibitors (letter)]: Unique Identifier : AIDSLINE MED/99060460; Soriano V; Rodriguez-Rosado R; Silva T; Gonzalez-Lahoz J
[Chlamydia as the agent responsible for disease in the immunosuppressed and transplanted patient]: Rev Clin Esp. 1998 Sep;198 Suppl 1:35-9. Unique Identifier : AIDSLINE MED/99052492; Munoz Garcia-Paredes P; Bouza Santiago E; Servicio de Microbiologia Clinica, Hospital General; Universitario Gregorio Maranon, Universidad Complutense de; Madrid.
[Macrolide prophylaxis in patients with HIV-1 infection or other forms of immunosuppression]: Rev Clin Esp. 1998 Sep;198 Suppl 1:59-65. Unique Identifier : AIDSLINE MED/99052496; Garcia Alcaide F; Gatell Artigas JM; Servicio de Infecciones, Hospital Clinic i Provincial, Barcelona.
[The 2nd International Seminar on HIV/AIDS Infection in Cuba (editorial)]: Rev Cubana Med Trop. 1995;47(2):81-2. Unique Identifier : AIDSLINE MED/99021890; Tapanes R; Perez Avila J
[Pulmonary crytosporidium in a patient with AIDS]: Rev Mal Respir. 1998 Sep;15(4):549-53. Unique Identifier : AIDSLINE MED/99022610; Stern JB; Antoine M; Roux P; Mayaud C; Cadranel J; Service de Pneumologie et de Reanimation respiratoire, Hopital; Tenon, Paris.; Compared to digestive disorders, respiratory disease linked to cryptosporidium has not been very well documented in AIDS. We report a case of a patient suffering from AIDS who presented with chronic bronchial symptoms which became more and more incapacitating. Different respiratory specimens (broncho-alveolar lavage,
[Mechanisms of bronchial obstruction in COPD and emphysema: from anatomopathology to respiratory function]: Rev Mal Respir. 1998 Sep;15 Suppl 2:S17-9. Unique Identifier : AIDSLINE MED/99026865; Saetta M
Specific and non-specific immunity to Candida albicans: a lesson from genetically modified animals.: Res Immunol. 1998 May-Jun;149(4-5):352-61; discussion 517-9. Unique Identifier : AIDSLINE MED/98385907; Mencacci A; Cenci E; Bistoni F; Bacci A; Del Sero G; Montagnoli C; Fe d'Ostiani C; Romani L; Department of Experimental Medicine and Biochemical Sciences,; University of Perugia, Italy.
Cytokines in allergic bronchopulmonary aspergillosis.: Res Immunol. 1998 May-Jun;149(4-5):466-77; discussion 515-6. Unique Identifier : AIDSLINE MED/98385918; Kurup VP; Grunig G; Knutsen AP; Murali PS; Allergy-Immunology Division, Medical College of Wisconsin and VA; Medical Center, Milwaukee 53295, USA.
Host-fungal interactions in HIV infection.: Res Immunol. 1998 May-Jun;149(4-5):489-93; discussion 516-7. Unique Identifier : AIDSLINE MED/98385920; Levitz SM; The Evans Memorial Department of Clinical Research, Boston; University School of Medicine, MA 02118-2393, USA.
Typing with internal transcribed spacer regions of Pneumocystis carinii from AIDS patients with recurrent pneumonia.: Res Microbiol. 1998 Sep;149(8):595-9. Unique Identifier : AIDSLINE MED/99012089; Margutti P; Visconti E; Mencarini P; Zolfo M; Marinaci S; Tamburrini E; Siracusano A; Ortona E; Dept. of Immunology, Istituto Superiore di Sanita, Rome.
Detection of avian reovirus RNA and comparison of a portion of genome segment S3 by polymerase chain reaction and restriction enzyme fragment length polymorphism.: Res Vet Sci. 1998 Jul-Aug;65(1):11-5. Unique Identifier : AIDSLINE MED/98440002; Lee LH; Shien JH; Shieh HK; Department of Veterinary Medicine, National Chung Hsing; University, Taichung, Taiwan.; A reverse transcription-polymerase chain reaction (RT-PCR) was established to amplify a 672-base pairs fragment on the segment S3 of avian reovirus (ARV). The amplified fragments were detected in nine strains of ARV as well as three tendon tissue specimens, indicating that the primer regions were well conserved. The R
Investigation of the cellular tropism of bovine immunodeficiency-like virus.: Res Vet Sci. 1998 Jul-Aug;65(1):33-40. Unique Identifier : AIDSLINE MED/98440006; Heaton PR; Johnstone P; Brownlie J; Rabies Research and Diagnostic Group, Veterinary Laboratories; Agency, Addlestone, Surrey. pheaton@hgmp.mrc.ac.uk; Bovine immunodeficiency-like virus (BIV) was first isolated from an animal showing transient leucocytosis, lymphadenopathy, lesions in the central nervous system and progressive weakness and emaciation. Similar signs are observed in other immunosuppressive lentiviral infections. BIV, like other lentiviruses, has been
[Zidovudine plus didanosine in HIV infected asymptomatic patients previously treated with zidovudine]: Rev Invest Clin. 1998 Jul-Aug;50(4):335-9. Unique Identifier : AIDSLINE MED/99048015; Lopez-Martinez C; Guarner J; Magis-Rodriguez C; Uribe-Zuniga P; del Rio-Chiriboga C; Consejo Nacional para la Prevencion y Control del SIDA; (CONASIDA), Mexico, D.F.; OBJECTIVE: To evaluate if the combination of AZT /ddl offered any advantages in surrogate markers among HIV infected asymptomatic patients previously treated with AZT for at least six months. METHODS: We used a prospective cohort of 269 asymptomatic HI
Unusual extracranial complications of otitis media in a young HIV patient: retropharyngeal and Mouret's abscess.: Rev Laryngol Otol Rhinol (Bord). 1998;119(3):199-201. Unique Identifier : AIDSLINE MED/98442205; Mevio E; Calabro P; De Paoli F; Maccabruni A; Michelone G; University of Pavia and IRCCS, Policlinico San Matteo, Department; of Otorhinolaringology, Italy.; Since the introduction of antibiotic therapy, the incidence of intra- and extracranial suppurative complication of acute and chronic purulent otitis media has sharply decreased. In particular, reports of laterocervical abscesses secondary to this disorder are quite rare, not more than twenty cases of Bezold s or Moure
[Polyarthritis in hepatitis C virus infection (letter)]: Rev Med Chil. 1998 Jun;126(6):725-6. Unique Identifier : AIDSLINE MED/98451903; Brahm J; Poniachik J; Oksenberg D
[Gene therapy and its applications]: Rev Med Chil. 1998 Jul;126(7):838-45. Unique Identifier : AIDSLINE MED/99048470; Austin-Ward ED; Villaseca C; Departamento de Medicina, Hospital Clinico Universidad de Chile,; Santiago, Chile.; Gene therapy consists in the introduction of genes in cells of the human organism. It allows the treatment of not only monogenic diseases (those in which one gene is altered, such as rare enzymatic diseases), but also of diseases in which there is an acquired gene alteration such as AIDS and cancer, and diseases in wh
[The role of superantigens in infectious diseases]: Rev Med Chil. 1998 Jul;126(7):846-54. Unique Identifier : AIDSLINE MED/99048471; Santolaya ME; Unidad de Infecciosos, Servicio de Pediatria, Hospital Luis; Calvo Mackenna.; Exogenous antigens are presented to T lymphocytes through mechanisms that ensure high recognition specificity. Recently described superantigens in contrast to conventional antigens are particles that follow a different processing and presentation route not binding to a specific region of T lymphocyte receptors. These
A comparison of smoothing techniques for CD4 data measured with error in a time-dependent Cox proportional hazards model.: Stat Med. 1998 Sep 30;17(18):2061-77. Unique Identifier : AIDSLINE MED/99006343; Bycott P; Taylor J; Department of Biometrics, Parke-Davis Pharmaceutical Research,; Ann Arbor, MI 48105, USA.; The use of CD4+ T-lymphocyte counts as a covariate presents some unique challenges in survivorship analyses due to the variability of this marker. If one does not account for the measurement error component of this variability in some manner, the estimate of the relative risk parameter in a time-dependent Cox model is
Sampling biases and missing data in explorations of sexual partner networks for the spread of sexually transmitted diseases.: Stat Med. 1998 Sep 30;17(18):2079-97. Unique Identifier : AIDSLINE MED/99006344; Ghani AC; Donnelly CA; Garnett GP; Wellcome Trust Centre for the Epidemiology of Infectious Disease,; Department of Zoology, University of Oxford, U.K.; azra.ghani@zoo.ox.ac.uk; The structures of sexual partner networks are important in determining patterns of transmission of STDs including HIV. Empirical data on sexual partnerships and sexual partner networks collected through sampling individuals are a non-random sample of partnerships and network structures even if individuals are sampled
Person-time analysis of paired community intervention trials when the number of communities is small.: Stat Med. 1998 Sep 30;17(18):2121-32. Unique Identifier : AIDSLINE MED/99006347; Brookmeyer R; Chen YQ; Department of Biostatistics, Johns Hopkins University, Baltimore,; MD 21205-2179, USA. rbrook@jhsph.edu; Community intervention trials involve randomization of communities to either an intervention or control arm. The objective of this paper is to evaluate person-time methods of analysis of paired community intervention trials when the number of community pairs is small. We consider several test procedures and evaluate t
[Perinatal HIV transmission prophylaxis in the Liege region]: Rev Med Liege. 1998 Aug;53(8):475-8. Unique Identifier : AIDSLINE MED/99027903; Jacquet Y; Hoyoux C; Dresse MF; Departement de Pediatrie, Hemato-oncologie, Universite de; Liege.; In Liege, since February 1994, Protocole ACTG 076 has been followed for prevention of perinatal transmission of VIH. The pregnant women are treated by AZT during pregnancy and delivery. The newborn is also treated during 6 weeks. Following this treatm
[Comorbidities in the addicted patient]: Rev Med Suisse Romande. 1998 Sep;118(9):747-50. Unique Identifier : AIDSLINE MED/99027880; Meiler A; Rivier E; Unite hospitaliere Seran, Chene-Bourg.
Detection of mycoplasmas in urethral swabs from HIV-1 infected patients and control individuals using culture techniques and polymerase chain reaction.: Rev Inst Med Trop Sao Paulo. 1998 Jan-Feb;40(1):1-5. Unique Identifier : AIDSLINE MED/98378751; da Cunha RA; Takei K; Vaz AJ; Rosenthal C; Faculdade de Ciencias Farmaceuticas da Universidade de Sao; Paulo, Brazil.; The objective of the present study was to determine the prevalence of certain mycoplasma species, i.e., Mycoplasma hominis, Ureaplasma urealyticum and Mycoplasma penetrans, in urethral swabs from HIV-1 infected patients compared to swabs from a control group. Mycoplasmas were detected by routine culture techniques and
Acute disseminated histoplasmosis and endocarditis.: Rev Inst Med Trop Sao Paulo. 1998 Jan-Feb;40(1):19-22. Unique Identifier : AIDSLINE MED/98378755; Scapellato PG; Desse J; Negroni R; Hospital de Infecciosas F. J. Muniz, Buenos Aires, Argentina.; Acute disseminated histoplasmosis is a frequent condition in HIV carriers. Thirty-five cases of endocarditis caused by Histoplasma capsulatum have been reported in international literature, and all these descriptions correspond to a context of subacute disseminated histoplasmosis. This paper presents the case of a HIV
Detection of HTLV-I antibodies and DNA in blood sample of a patient with myelopathy in Nigeria.: Rev Inst Med Trop Sao Paulo. 1998 Jan-Feb;40(1):55-7. Unique Identifier : AIDSLINE MED/98378761; Olaleye OD; Ogunniyi A; Sheng ZJ; Li Z; Rasheed S; Department of Virology, College of Medicine, University College; Hospital, Ibadan, Nigeria.; We describe a case of human T-lymphotropic virus type I associated myelopathy in a 50-year old woman in Nigeria . The patient presented with progressive loss of tone to the two lower limbs and later inability to walk. The HTLV-I antibody presence in the plasma collected from the pa
[Protection of hospital personnel against risks of exposure to blood]: Rev Prat. 1998 Sep 15;48(14):1558-62. Unique Identifier : AIDSLINE MED/99031595; Bouvet E; Tarantola A; Clinique de reanimation des maladies infectieuses, Groupe; hospitalier Bichat-Claude-Bernard, Paris.; Exposures to blood are frequent during health care, invasive nurse procedures (phlebotomy, catheterisation) and in the operating theatre. They carry a risk o