1999

Synthesis and anti-virus activity of some nucleosides analogues.: Z Naturforsch [C]. 1999 Jan-Feb;54(1-2):75-83. Unique Identifier : AIDSLINE MED/99197481; Stankova IG; Simeonov MF; Maximova V; Galabov AS; Golovinsky EV; Department of Chemistry, South-West University Neofit Rilski,; Blagoevgrad, Bulgaria. ivankast@aix.swu.bg; New 3 -, 5 -, 5-bromo-2 -deoxyuridine (3a-g) and 3 -, 5 -thymidine (4a-i) analogues with amino acid and peptide residues were synthesized and evaluated for antiviral activity. The influence of long peptide chains, essential amino acids and the effect of this structural modification on the antiviral activity has been a
Follow-up essential for positive home HIV test results [news]: Oncology (Huntingt). 1999 Jan;13(1):81. Unique Identifier : AIDSLINE MED/99151262
Fludarabine, cyclophosphamide, and dexamethasone (FluCyD) combination is effective in pretreated low-grade non-Hodgkin's lymphoma.: Ann Oncol. 1999 Jan;10(1):59-64. Unique Identifier : AIDSLINE MED/99176019; Lazzarino M; Orlandi E; Montillo M; Tedeschi A; Pagnucco G; Astori C; Corso A; Brusamolino E; Simoncini L; Morra E; Bernasconi C; Institute of Hematology, University of Pavia, Italy.; mlazzarino@smatteo.pv.it; PURPOSE: Fludarabine phosphate is effective as a single agent in low-grade non-Hodgkin s lymphoma (NHL). Combined with other antineoplastic agents it enhances the antitumor effect. Our aim was to define the therapeutic efficacy and toxicity of a combination of fludarabine, cyclopho
Cystoid macular oedema and cytomegalovirus retinitis in patients with HIV disease treated with highly active antiretroviral therapy.: Br J Ophthalmol. 1999 Jan;83(1):47-9. Unique Identifier : AIDSLINE MED/99225909; Cassoux N; Lumbroso L; Bodaghi B; Zazoun L; Katlama C; LeHoang P; Department of Ophthalmology, Pitie-Salpetriere Hospital,; Paris, France.; BACKGROUND: Although cystoid macular oedema (CMO) is a rare cause of visual loss in AIDS related cytomegalovirus ( CMV ) retinitis, nine cases are reported of CMO occurring in HIV infected patients with a prior diagnosis of CMV
High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates.: Bioconjug Chem. 1999 Mar-Apr;10(2):186-91. Unique Identifier : AIDSLINE MED/99177071; Josephson L; Tung CH; Moore A; Weissleder R; Center for Molecular Imaging Research, Massachusetts General; Hospital, Boston, Massachusetts 02129, USA.; A biocompatible, dextran coated superparamagnetic iron oxide particle was derivatized with a peptide sequence from the HIV-tat protein to improve intracellular magnetic labeling of different target cells. The conjugate had a mean particle size of 41 nm and contained an average of 6.7 tat peptides. Derivatized particle
[Human immunodeficiency virus (HIV) infection. The effectiveness of different diagnostic sequences in suspected pulmonary infection]: An Med Interna. 1999 Jan;16(1):15-20. Unique Identifier : AIDSLINE MED/99189515; Cortes Blanco A; Saez Lavilla C; Martinez Lazaro R; Arazo Garces P; Borraz Lopez MV; Ascaso Bandres A; Servicio de Medicina Nuclear, Hospital Miguel Servet, Zaragoza.; BACKGROUND: Assessment of different diagnostic sequences, in patients VIH(+) with a suspected pulmonary infection. METHODS: A cross-sectional descriptive study of 76 HIV(+) patients with suspected respiratory infection. It has been determined the validity and the pretest and post-test probability of the radiology (Rx)
[A pulmonary cellular immunity study in HIV patients]: An Med Interna. 1999 Jan;16(1):21-4. Unique Identifier : AIDSLINE MED/99189516; Fernandez Fabrellas E; Gonzalez Constan E; Marin Gonzalez M; Leon P; Blanquer Olivas R; Servicio de Neumologia, Hospital Dr. Peset Aleixandre, Valencia.; BACKGROUND: Cellular immunity disorder, showed by a decreased blood level of lymphocytes T CD4, is the main indicator of progression in HIV infection. The diminished level of these lymphocytes and CD4/CD8 ratio in pulmonary samples obtained by bronchoalveolar lavage (BAL) is known, so as the enhanced level of lymphocy
[Acute pancreatitis due to amphotericin B in an HIV-positive patient (letter)]: An Med Interna. 1999 Jan;16(1):47-8. Unique Identifier : AIDSLINE MED/99189523; Catalan I; Supervia A; Saballs P; Blanco ML
[An oral ulcer due to cytomegalovirus in a patient with the acquired immunodeficiency syndrome (letter)]: An Med Interna. 1999 Jan;16(1):53. Unique Identifier : AIDSLINE MED/99189530; Mendiburu Belzunegui L; Pena Garcia A; Sanchez Sanchez C; Font Cervero A
[The effect of human immunodeficiency virus infection on the consumption of hospital resources. A correlation with the degree of immunodeficiency]: An Med Interna. 1999 Jan;16(1):8-14. Unique Identifier : AIDSLINE MED/99189514; Rovira Daudi E; Gonzalez Monte C; Belda Mira A; Pascual Izuel JM; Gonzalvo Bellver F; Hospital de Sagunto, Servicio Valenciano de Salud, Valencia.; BACKGROUND: To calculate the real cost of the Human Immunodeficiency Virus (HIV) infection in the use of hospital resources. PATIENTS AND METHODS: All the episodes of hospitalization of the years 1993, 1994 and 1995 of a general hospital have been analyzed. The patients have been classified according to the Patients M
Sharing the dance toward the next century [editorial]: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):20-1. Unique Identifier : AIDSLINE MED/99164800; Highsmith C
Lipid abnormalities associated with protease inhibitors.: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):22-30. Unique Identifier : AIDSLINE MED/99164801; Melroe NH; Kopaczewski J; Henry K; Huebsch J; HIV Programs at Regions Hospital in St. Paul, Minnesota, USA.; Treatment for HIV infection in the past 3 years has significantly improved the prognosis of people infected with HIV. Protease inhibitors have played a critical role in this improved prognosis. Recent findings indicate, however, that protease inhibitors may cause si
Hepatitis A and HIV: a clinical review of disease and strategies for prevention.: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):31-6. Unique Identifier : AIDSLINE MED/99164802; Kwong JJ; Fenway Community Health Center, Boston, USA.; Hepatitis A, also known as infectious hepatitis, remains one of the more commonly transmitted types of viral hepatitis in the United States . Given the high prevalence of this illness, clinicians need to be aware not only about the clinical manifestations of this disease, but also about
Quality of life and self-care management strategies of PLWAs with chronic diarrhea.: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):46-54. Unique Identifier : AIDSLINE MED/99164803; Henry SB; Holzemer WL; Weaver K; Stotts N; Department of Community Health Systems, University of California,; San Francisco, USA.; A case control design was used to examine quality of life and self-care management strategies in persons living with AIDS (PLWAs) with chronic diarrhea. PLWAs without chronic diarrhea (n = 20) as compared to those with chronic diarrhea (n = 20) reported significantly higher general health perceptions (p = .028). In co
Nurses decrease barriers to health care by "hyperlinking" multiple-diagnosed women living with HIV/AIDS into care.: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):55-65. Unique Identifier : AIDSLINE MED/99164804; Andersen MD; Smereck GA; Hockman EM; Ross DJ; Ground KJ; Well-Being Institute, USA.; The Well-Being Institute (WBI), a community-based nursing organization in Detroit, Michigan, has developed and put into practice innovative intervention and service delivery models to assist HIV-positive women who have a history of substance abuse and mental illness. These multiple-diagnosed women are known to have sp
The expressed needs of a group of HIV-infected gay men subsequent to hospital care.: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):66-74. Unique Identifier : AIDSLINE MED/99164805; Cederfjall C; Wredling R; Department of Internal Medicine, Karolinska Hospital.; A qualitative study was conducted to explore how a group of HIV-infected gay men experienced their encounters with the health care community and to develop a theoretical understanding of the care given from the patient s perspective. Ten HIV-infected gay men were recruited from an outpatient clinic in a city in the so
Special population: HIV/AIDS among the deaf and hard of hearing.: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):75-8. Unique Identifier : AIDSLINE MED/99164806; Gaskins S; Capstone College of Nursing, University of Alabama, USA.
Searching for HIV/AIDS information on the World Wide Web.: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):79-81. Unique Identifier : AIDSLINE MED/99164807; Mann CE; WW Clark Memorial Library, University of Portland, USA.; Providing patients and their families with information on HIV/AIDS can be a challenge given the entire range of tissues that come packaged with the disease itself. Information on treatment and resources changes rapidly due to the nature of the disease, and it can be difficult to have printed sources on hand that are u
Thalidomide: the past, present, and future.: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):82-4. Unique Identifier : AIDSLINE MED/99164808; Porche D; Nicholls State University, USA.; Treatment Review is intended to inform and update nurses about treatments relevant to HIV/AIDS. Product information presented in this column does not imply endorsement by the Association of Nurses in AIDS Care.
New CDC guidelines call for TB screening and treatment for all HIV-infected individuals [news]: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):85-6. Unique Identifier : AIDSLINE MED/99164809
Results of simplified screening for Chlamydia in female military recruits suggest testing for all sexually active young women [news]: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):86-7. Unique Identifier : AIDSLINE MED/99164810
New study showed average costs of care for HIV in managed care were lower for patients with undetectable viral loads [news]: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):87-8. Unique Identifier : AIDSLINE MED/99164811
Idiopathic CD4+ T lymphocytopenia disclosed by the onset of empyema thoracis.: Intern Med. 1999 Jan;38(1):40-4. Unique Identifier : AIDSLINE MED/99160106; Hamanishi T; Nakao T; Nishino M; Yanagawa T; Kobayashi M; Sasaki H; Matsumoto G; Sanke T; Nanjyo K; First Department of Medicine, Wakayama University of Medical; Science.; A 56-year-old man was admitted to our hospital in December 1996 due to empyema thoracis. A laboratory examination revealed lymphocytopenia and CD4+ T lymphocytopenia (
Idiopathic CD4+ T-lymphocytopenia in chronic obstructive pulmonary disease [letter]: Intern Med. 1999 Jan;38(1):71-2. Unique Identifier : AIDSLINE MED/99160113; Matsuyama W; Mizoguchi A; Hamasaki T; Wakimoto J; Iwami F; Kawabata M; Osame M
[The effect of chaihu qingxin yin on left cardiac function and T-cell subgroup in peripheral blood in children with viral myocarditis]: Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1997 Feb;17(2):73-5. Unique Identifier : AIDSLINE MED/99029202; Wang XF; Yan WC; Guo ZW; Liaoning College of Traditional Chinese Medicine, Shenyang.; OBJECTIVE: To observe the effect of Caihu Qingxin Yin (CHQXY) in treating viral myocarditis. METHODS: CHQXY was used to treat 52 cases of acute viral myocarditis in children, compared with the routine method using energy mixture in 32 patients. RESULTS: (1) The total effective rate of 52 patients using CHQXY was 71.2%
Paralytic poliomyelitis associated with live oral poliomyelitis vaccine in child with HIV infection in Zimbabwe: case report.: BMJ. 1999 Mar 27;318(7187):841-3. Unique Identifier : AIDSLINE MED/99192485; Chitsike I; van Furth R; Departments of Paediatrics and Immunology, Medical School of the; University of Zimbabwe, PO Box A 178, Harare, Zimbabwe.; OBJECTIVE: To describe a complication of oral vaccination with live, attenuated poliomyelitis virus in a child infected with HIV. DESIGN: Case report. SETTING: Teaching hospital in Harare, Zimbabwe . SUBJECTS: A boy of 41/2 years and his mother. MAIN OUTCOME MEASURES: Results of c
The SCID/Beige mouse as a model to investigate protection against Yersinia pestis.: FEMS Immunol Med Microbiol. 1999 Feb;23(2):107-13. Unique Identifier : AIDSLINE MED/99174525; Green M; Rogers D; Russell P; Stagg AJ; Bell DL; Eley SM; Titball RW; Williamson ED; DERA, Chemical and Biological Defense Sector, Salisbury,; Wiltshire, UK.; In this study, we have shown that severe combined immunodeficient/beige mice reconstituted with hyperimmune Balb/c lymphocytes can be used as a model to demonstrate adoptive and passive protection against plague infection. Reconstitution of severe combined immunodeficient/beige mice was successful in nine out of ten m
Live antigen carriers as tools for improved anti-tuberculosis vaccines.: FEMS Immunol Med Microbiol. 1999 Feb;23(2):165-73. Unique Identifier : AIDSLINE MED/99174532; Hess J; Kaufmann SH; Max-Planck-Institute for Infection Biology, Department of; Immunology, Berlin, Germany. Hess@mpiib-berlin.mpg.de; Recombinant (r) Mycobacterium bovis BCG strains have been constructed which secrete biologically active listeriolysin (Hly) fusion protein of Listeria monocytogenes. In human and murine macrophage-like cell lines, intracellular persistence of these r-BCG strains was reduced as compared to the parental BCG strain. By i
Genetic and non-genetic determination of repeatability of blood and milk indices in black-and-white cows.: Arch Vet Pol. 1993;33(3-4):165-76. Unique Identifier : AIDSLINE MED/99203797; Walawski K; Kaczmarczyk E; Sowinski G; Czarnik U; Zabolewicz T; Biallowicz E; Department of Animal Genetics, University of Agriculture and; Technology, Olsztyn, Poland.; A herd of cows of the same age, kept in a stable system under controlled environmental conditions, was used to estimate the repeatability of diagnostic blood and milk indices in several stages of the I, II and III lactation. Attention was paid to genetic and non-genetic sources of phenotypic variation. Statistically s
[Pediatric AIDS: epidemiological, clinical and prognostic aspects in Abidjan, Ivory Coast (letter)]: Arch Pediatr. 1999 Mar;6(3):342-3. Unique Identifier : AIDSLINE MED/99207638; Niangue-Beugre NM; Oulai MS; Gonty L; Orega M; Plo KJ; Andoh J
[Specific immunotherapy]: Arch Pediatr. 1999;6 Suppl 1:108S-113S. Unique Identifier : AIDSLINE MED/99207659; Just J; Houzel-Charavel A; Grimfeld A; Polyclinique de pneumologie pediatrique, hopital d'Enfants; Armand-Trousseau, Paris, France.; Increase of the prevalence of allergy these last 20 years is in part secondary to the modification of the allergenic charge of our environment. The specific immunotherapy (SIT) is the only etiologic treatment of the allergic disease and numbers of authors believe that, for the future, this treatment could change the n
Proxy, health, and personal care preferences: implications for end-of-life care.: Camb Q Healthc Ethics. 1999 Spring;8(2):200-10. Unique Identifier : AIDSLINE MED/99166163; Aikman PJ; Thiel EC; Martin DK; Singer PA; Dalhousie University.
Placental antibody transfer: influence of maternal HIV infection and placental malaria.: Arch Dis Child Fetal Neonatal Ed. 1998 Nov;79(3):F202-5. Unique Identifier : AIDSLINE MED/99210896; de Moraes-Pinto MI; Verhoeff F; Chimsuku L; Milligan PJ; Wesumperuma L; Broadhead RL; Brabin BJ; Johnson PM; Hart CA; Department of Medical Microbiology, University of Liverpool.; AIM: To determine the influence of placental malaria, maternal HIV infection, and maternal hypergammaglobulinaemia on transplacental IgG antibody transfer. METHODS: One hundred and eighty materno-neonatal pairs from a Malawian population were assessed. Cord and maternal serum samples were tested for total serum IgG an
A cis proline turn linking two beta-hairpin strands in the solution structure of an antibody-bound HIV-1IIIB V3 peptide.: Nat Struct Biol. 1999 Apr;6(4):331-5. Unique Identifier : AIDSLINE PDB/1B03; Tugarinov V; Zvi A; Levy R; Anglister J; Department of Structural Biology, The Weizmann Institute of; Science, Rehovot, Israel.; The refined solution structure of an 18-residue HIV-1IIIB V3 peptide in complex with the Fv fragment of an anti-gp120 antibody reveals an unexpected type VI beta-turn comprising residues RGPG at the center of a beta-hairpin. The central glycine and proline of this turn are linked by a cis peptide bond. The residues of
A novel role for the major histocompatibility complex class II transactivator CIITA in the repression of IL-4 production.: Immunity. 1999 Mar;10(3):377-86. Unique Identifier : AIDSLINE MED/99219187; Gourley T; Roys S; Lukacs NW; Kunkel SL; Flavell RA; Chang CH; Department of Microbiology and Immunology, University of Michigan; Medical School, Ann Arbor 48109, USA.; Class II transactivator (CIITA) is known as a coactivator for MHC class II gene expression in antigen-presenting cells. Surprisingly, when CIITA-/- CD4 T cells were stimulated in the presence of IL-12, they produced not only IFNgamma but also high levels of IL-4. The IL-4 production is due to the accumulation of IL-4
The role of IgE in asthma.: Clin Exp Allergy. 1998 Nov;28 Suppl 5:104-9; discussion 117-8. Unique Identifier : AIDSLINE MED/99140984; Yssel H; Abbal C; Pene J; Bousquet J; Clinique des Maladies Respiratoires and INSERM U454, Hopital; Arnaud de Villeneuve, Montpellier, France.; Asthma is a multifactorial and complex disease in which allergic factors and non-allergic triggers interact and result in bronchial obstruction and inflammation. Allergenic sensitization is important in the development of asthma and, although links between inhalant allergy and asthma have been known for many years, th
Reciprocal age-related patterns of allergen-specific T-cell immunity in normal vs. atopic infants.: Clin Exp Allergy. 1998 Nov;28 Suppl 5:39-44; discussion 50-1. Unique Identifier : AIDSLINE MED/99140975; Prescott SL; Macaubas C; Smallacombe T; Holt BJ; Sly PD; Loh R; Holt PG; TVW Telethon Institute for Child Health Research, West Perth,; Western Australia, Australia.; By adulthood there is almost universal immunological memory to aeroallergens, and the presence of allergic disease appears to be related to the nature of the underlying T-helper (Th) cell cytokine responses. The hypothesis of this study is that adult patterns of allergen specific Th-cell memory (Th-2 polarized in atop
Immunoregulatory networks in asthma.: Clin Exp Allergy. 1998 Nov;28 Suppl 5:92-6; discussion 117-8. Unique Identifier : AIDSLINE MED/99140982; Le Gros G; Erb K; Harris N; Holloway J; McCoy K; Ronchese F; Malaghan Institute of Medical Research, Wellington, New Zealand.; It is now well established that a subset of T-cell-derived cytokines (termed Th2 cytokines) programme the timing and characteristics of atopic airway disease including mast-cell sensitization, eosinophil and lymphocyte infiltration and recently mucus secretion. To date, attempts to devise ways to selectively limit the
Is allergy increasing?--early life influences.: Clin Exp Allergy. 1998 Dec;28 Suppl 6:2-7. Unique Identifier : AIDSLINE MED/99140956; Howarth PH; University Medicine, Southampton General Hospital, UK.; Data from epidemiological studies conducted in several countries worldwide have revealed that the prevalences of allergic conditions, including allergic rhinitis, asthma and eczema, have increased from the 1940s/50s to the 1990s. These allergic conditions involve specific IgE-mediated responses, and a few studies have
Epicutaneous administration of hapten through patch application augments TH2 responses which can downregulate the elicitation of murine contact hypersensitivity.: Clin Exp Allergy. 1999 Feb;29(2):271-9. Unique Identifier : AIDSLINE MED/99170084; Wang LF; Sun CC; Wu JT; Lin RH; Graduate Institute of Microbiology, Department of Dermatology,; College of Medicine, National Taiwan University, Taipei, Republic; of China.; BACKGROUND AND OBJECTIVE: Allergic contact dermatitis and its animal model, contact hypersensitivity (CHS), have long been documented as type 1 T-cell-predominant immune responses. Although type 1/type 2 T-cell deviation has been repeatedly demonstrated to play an important role in many human diseases and their animal
Norm values for eosinophil cationic protein in nasal secretions: influence of specimen collection.: Clin Exp Allergy. 1999 Mar;29(3):367-74. Unique Identifier : AIDSLINE MED/99221991; Klimek L; Rasp G; Department of Otorhinolaryngology, Johannes Gutenberg University,; Mainz, Germany.; BACKGROUND: Eosinophil granulocytes play an important role in allergic inflammation of the nasal mucosa. Eosinophil cationic protein (ECP) is a specific eosinophil granule protein released upon activation of these cells. ECP concentration in nasal secretions has been demonstrated to be a good marker for the activity o
Attenuation of house dust mite Dermatophagoides farinae-induced airway allergic responses in mice by dehydroepiandrosterone is correlated with down-regulation of TH2 response.: Unique Identifier : AIDSLINE MED/99221998; Yu CK; Yang BC; Lei HY; Chen YC; Liu YH; Chen CC; Liu CW; BACKGROUND: Dehydroepiandrosterone (DHEA), an abundant androgen in circulation, has important immunomodulating effects on T-cell differentiation; however, it is not known whether this hormone influences allergic responses. OBJECTIVE: We have established a murine model of airway inflammation induced by house dust mite
Increased prevalence of malaria in HIV-infected pregnant women and its implications for malaria control.: Trop Med Int Health. 1999 Jan;4(1):5-12. Unique Identifier : AIDSLINE MED/99217817; Verhoeff FH; Brabin BJ; Hart CA; Chimsuku L; Kazembe P; Broadhead RL; Liverpool School of Tropical Medicine, UK.; OBJECTIVES: To examine in pregnant women the relationship between HIV infection and malaria prevalence and to determine, in relation to HIV infection, the effectiveness of sulphadoxine-pyrimethamine in clearing P. falciparum infection. METHOD: Descriptive cross-sectional analysis of P. falciparum prevalence in pregnan
Evaluation of a quantitative determination of CD4 and CD8 molecules as an alternative to CD4+ and CD8+ T lymphocyte counts in Africans.: Trop Med Int Health. 1999 Feb;4(2):79-84. Unique Identifier : AIDSLINE MED/99221101; Diagbouga S; Durand G; Sanou PT; Dahourou H; Ledru E; Centre MURAZ, Organization de Coordination et de Cooperation; pour la lutte contre les Grandes Endemies, Bobo-Dioulasso,; Burkina Faso. griv.muraz@fasonet.bf; In the developed word, monitoring HIV-infected patients is routinely determined by CD4+ T lymphocyte absolute counts. The reference procedure, flow cytometry, is expensive, requires sophisticated instrumentation and operators with specific training. Due to these limitations, CD4 counting is often unavailable in develo
Oral hairy leukoplakia in a patient with acute lymphocytic leukemia.: Unique Identifier : AIDSLINE MED/99234668; Nicolatou O; Nikolatos G; Fisfis M; Belegrati M; Papadaki T; Oikonomaki E; Kalmantis T; Department of Oral Pathology and Surgery, School of Dentistry,; University of Athens, Greece.; The first case of oral hairy leukoplakia (OHL) in an HIV-negative 56-year-old patient with acute lymphocytic leukemia (ALL) is reported. A white plaque was observed while the patient was in complete remission which followed the chemotherapeutic scheme. The clinical and histopathologic findings were typical for OHL and
NIH appoints a director for its AIDS vaccine center [news]: Nat Med. 1999 Apr;5(4):362. Unique Identifier : AIDSLINE MED/99217559; Birmingham K
Finding funding for China's HIV research [news]: Nat Med. 1999 Apr;5(4):364-5. Unique Identifier : AIDSLINE MED/99217562; Watanabe ME
Fetal immunization of baboons induces a fetal-specific antibody response.: Unique Identifier : AIDSLINE MED/99217583; Watts AM; Stanley JR; Shearer MH; Hefty PS; Kennedy RC; Neonates face a high risk of infection because of the immaturity of their immune systems. Although the transplacental transfer of maternal antibodies to the fetus may convey improved postnatal immunity, this transfer occurs late in gestation and may fail to prevent in utero infection. Both fetal immunization and in ut
Syphilis: review with emphasis on clinical, epidemiologic, and some biologic features.: Clin Microbiol Rev. 1999 Apr;12(2):187-209. Unique Identifier : AIDSLINE MED/99212045; Singh AE; Romanowski B; Alberta Health STD Services, University of Alberta, Edmonton,; Alberta, Canada.; Syphilis is a chronic disease with a waxing and waning course, the manifestations of which have been described for centuries. It occurs worldwide, and the incidence varies significantly with geographic location. Transmission is mainly by sexual contact. The causative organism, Treponema pallidum, was first described i
Molecular techniques for detection, species differentiation, and phylogenetic analysis of microsporidia.: Clin Microbiol Rev. 1999 Apr;12(2):243-85. Unique Identifier : AIDSLINE MED/99212048; Franzen C; Muller A; Department of Internal Medicine I, University of Cologne, 50924; Cologne, Germany.Caspar.Franzen@Uni-Koeln.de; Microsporidia are obligate intracellular protozoan parasites that infect a broad range of vertebrates and invertebrates. These parasites are now recognized as one of the most common pathogens in human immunodeficiency virus-infected patients. For most patients with infectious diseases, microbiological isolation and id
Resistance of human cytomegalovirus to antiviral drugs.: Unique Identifier : AIDSLINE MED/99212049; Erice A; Resistance of cytomegalovirus ( CMV ) to antiviral agents is a well-recognized phenomenon that has been observed in the laboratory and in the clinical setting. Infections caused by antiviral-resistant CMV have been found exclus
[T-lymphocyte subgroup and the nature killer cell activity in cardiovascular diseases]: Hunan I Ko Ta Hsueh Hsueh Pao. 1997;22(6):535-6. Unique Identifier : AIDSLINE MED/99172655; Xie X; Dai T
Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes.: Cell. 1999 Apr 2;97(1):63-73. Unique Identifier : AIDSLINE MED/99213495; Piguet V; Gu F; Foti M; Demaurex N; Gruenberg J; Carpentier JL; Trono D; Department of Genetics, Faculty of Medicine, University of; Geneva, Switzerland.; The Nef protein of primate lentiviruses downregulates the cell surface expression of CD4 through a two-step process. First, Nef connects the cytoplasmic tail of CD4 with adaptor protein complexes (AP), thereby inducing the formation of CD4-specific clathrin-coated pits that rapidly endocytose the viral receptor. Secon
Single cell analysis of antigen-specific T cell responses in HIV-infected individuals.: Cell Immunol. 1999 Mar 15;192(2):107-12. Unique Identifier : AIDSLINE MED/99189157; Byl B; Gerard M; Libin M; Clumeck N; Goldman M; Mascart F; Hopital Erasme, Universite Libre de Bruxelles, Brussels,; B-1070, Belgium.; Antigen-specific and polyclonally induced T cell responses were analyzed in 10 HIV-infected individuals and in 14 controls by enumerating the numbers of tetanus toxoid (TT)-specific and phytohemagglutinin (PHA)-induced IFN-gamma-secreting cells (SC) and IL-4-SC using an enzyme-linked immunospot assay. Whereas the numb
Both CD4(+) T cells and CD8(+) T cells are required for iodine accelerated thyroiditis in NOD mice.: Cell Immunol. 1999 Mar 15;192(2):113-21. Unique Identifier : AIDSLINE MED/99189158; Hutchings PR; Verma S; Phillips JM; Harach SZ; Howlett S; Cooke A; Department of Pathology, University of Cambridge, Cambridge, CB2; 1QP, United Kingdom.; The nonobese diabetic (NOD) mouse, a spontaneous animal model for insulin-dependent diabetes mellitus, displays a tendency in common with human diabetic populations to develop autoimmune thyroiditis although incidence and severity of thyroid lesions vary widely among different colonies around the world. A congenic str
DOTS and drug resistance: a silver lining to a darkening cloud [editorial; comment]: Int J Tuberc Lung Dis. 1999 Jan;3(1):1-3. Unique Identifier : AIDSLINE MED/99191950; Chaisson RE; Coberly JS; De Cock KM
Risk factors for tuberculosis in patients with AIDS in London: a case-control study.: Int J Tuberc Lung Dis. 1999 Jan;3(1):12-7. Unique Identifier : AIDSLINE MED/99191952; Del Amo J; Petruckevitch A; Phillips AN; De Cock KM; Stephenson J; Desmond N; Hanscheid T; Low N; Newell A; Obasi A; Paine K; Pym A; Theodore C; Johnson AM; MRC UK Centre for Co-ordinating Epidemiological Studies of HIV; and AIDS, Department of STD, Mortimer Market Centre, London, UK.; jdelamo@isciii.es; OBJECTIVE: To identify risk factors for the acquired immune-deficiency syndrome (AIDS) associated with tuberculosis, in patients with AIDS attending 11 of the largest human immunodeficiency virus (HIV)/AIDS Units in London. DESIGN: Case-control study nested in a retrospective cohort of 2048 HIV-1 positive patients. Ca
Incidence of tuberculosis in a community of Senegalese immigrants in Northern Italy.: Int J Tuberc Lung Dis. 1999 Jan;3(1):18-22. Unique Identifier : AIDSLINE MED/99191953; Scolari C; El-Hamad I; Matteelli A; Signorini L; Bombana E; Moioli R; De Leonardis C; Nava AM; Carosi G; Clinic of Infectious and Tropical Diseases-University of Brescia,; Italy.; SETTING: Tuberculosis is the world s foremost cause of death from a single infectious agent among adults. Although morbidity and mortality rates are highest in low income countries, industrialized countries have also faced a recent resurgence of the tuberculosis epidemic. In Europe and the
Low levels of drug resistance amidst rapidly increasing tuberculosis and human immunodeficiency virus co-epidemics in Botswana [see comments]: Int J Tuberc Lung Dis. 1999 Jan;3(1):4-11. Unique Identifier : AIDSLINE MED/99191951; Kenyon TA; Mwasekaga MJ; Huebner R; Rumisha D; Binkin N; Maganu E; BOTUSA TB Project, Gaborone, Botswana, and Division of TB; Elimination, Centers for Disease Control and Prevention, Atlanta,; Georgia, USA. tak8@cdc.gov; SETTING: Botswana , southern Africa, where the tuberculosis (TB) case rate increased by 120% from 1989 to 1996 in spite of a decade of implementation of the directly observed therapy, short-course (DOTS) strategy. OBJECTIVE: To determine prevalence of and risk factors for drug-res
Prednisolone: a beneficial and safe adjunct to antituberculosis treatment? A randomized controlled trial.: Int J Tuberc Lung Dis. 1999 Jan;3(1):47-54. Unique Identifier : AIDSLINE MED/99191957; Bilaceroglu S; Perim K; Buyuksirin M; Celikten E; Department of Thoracic Medicine, Izmir Chest Diseases and Surgery; Training Hospital, Turkey. bsemra@turk.net; SETTING: A referral centre for thoracic diseases in Izmir, Turkey , 1992-1995. OBJECTIVE: To appraise the adjunctive role of prednisolone (PN) in pulmonary tuberculosis (PTB) with toxic reactions. DESIGN: After excluding other febrile causes, and 2 weeks of four/five-drug antituberc
Mycobacterium kansasii infection in a Paris suburb: comparison of disease presentation and outcome according to human immunodeficiency virus status. Groupe dEtude Des Mycobacteries de la Seine-Saint-Denis.: Int J Tuberc Lung Dis. 1999 Jan;3(1):68-73. Unique Identifier : AIDSLINE MED/99191960; Lortholary O; Deniel F; Boudon P; Le Pennec MP; Mathieu M; Soilleux M; Le Pendeven C; Loiseau P; Vincent V; Valeyre D; Service de Medecine Interne et Centre de Recherche en Pathologie; Infectieuse et Tropicale, Bobigny, France.; SETTING: Department of Seine-Saint-Denis, France . OBJECTIVE: To compare the presentation and outcome of Mycobacterium kansasii infections according to human immunodeficiency virus (HIV) status. DESIGN: Retrospective analysis of all the medical charts of adults meeting the diagnosti
High compliance in an ambulatory tuberculosis treatment programme in a rural community of Uganda.: Int J Tuberc Lung Dis. 1999 Jan;3(1):79-81. Unique Identifier : AIDSLINE MED/99191962; Nuwaha F; Department of Community Health, Mbarara University, Uganda.; The increasing numbers of clinical tuberculosis in Uganda , mainly due to the human immunodeficiency virus (HIV) epidemic, means that it is no longer possible to hospitalise all TB patients, and the feasibility of ambulatory treatment needs to be assessed. A successful ambulatory TB
Drug susceptibility of Mycobacterium tuberculosis in a rural area of Bangladesh and its relevance to the national treatment regimens.: Int J Tuberc Lung Dis. 1999 Feb;3(2):143-8. Unique Identifier : AIDSLINE MED/99190301; Van Deun A; Aung KJ; Chowdhury S; Saha S; Pankaj A; Ashraf A; Rigouts L; Fissette K; Portaels F; Damien Foundation Bangladesh, Dhaka.; SETTING: Greater Mymensingh District, a rural area of Bangladesh , at the start of the National Tuberculosis Programme (NTP). OBJECTIVES: To determine the prevalence of initial and acquired drug resistance of Mycobacterium tuberculosis, and to assess the appropriateness of the N
Use of incentives to increase compliance for TB screening in a population of intravenous drug users. Vancouver Injection Drug Use Study Group.: Int J Tuberc Lung Dis. 1999 Feb;3(2):153-5. Unique Identifier : AIDSLINE MED/99190303; FitzGerald JM; Patrick DM; Strathdee S; Rekart M; Elwood RK; Schecter MT; Montaner J; O'Shaughnessy M; British Columbia Centre for Disease Control Society, BC Centre; for Excellence in HIV/AIDS and the University of British; Columbia, Vancouver, Canada. mfitzgerald@mater.ie; SETTING: Intravenous drug users (IDUs) represent a high risk group for dual human immunodeficiency virus (HIV) and tuberculosis (TB) infection. Screening with TB skin testing has therefore been suggested in this group. Subjects compliance for returning to have TB skin test results read is a major problem. In the sett
Lymph node tuberculosis in the suburbs of Paris: 59 cases in adults not infected by the human immunodeficiency virus.: Int J Tuberc Lung Dis. 1999 Feb;3(2):162-5. Unique Identifier : AIDSLINE MED/99190305; Fain O; Lortholary O; Djouab M; Amoura I; Babinet P; Beaudreuil J; Boudon P; Desrues J; Glowinski J; Lhote F; Malbec D; Mathieu E; White C; Guillevin L; Thomas M; Department of Internal Medicine, Jean Verdier Hospital, Bondy,; France.; We report 59 cases of lymph node tuberculosis in adults not infected by the human immunodeficiency virus (HIV), observed over a period of 5 years in the North Eastern suburbs of Paris. There were 31 women and 28 men; 84.7% were aged under 44 years; 69.5% were not French, and 78% had exclusive lymph node tuberculosis.
Identification of Mycobacterium shimoidei by molecular techniques: case report and summary of the literature.: Unique Identifier : AIDSLINE MED/99190307; Mayall B; Gurtler V; Irving L; Marzec A
Gastrointestinal manifestations of HIV infection.: Hosp Med. 1999 Jan;60(1):24-8. Unique Identifier : AIDSLINE MED/99212843; Blanshard C; Academic Unit of Medical and Surgical Gastroenterology, Homerton; Hospital, London.; As patients with human immunodeficiency virus (HIV) infection become more immunocompromised, gastrointestinal symptoms become more common. Most symptoms result from opportunistic infections and can be diagnosed and treated by gastroenterologists, although medical microbiology and histopathology input is essential.
Kaposi's sarcoma in women: A clinicopathologic study.: J Cutan Med Surg. 1999 Jan;3(3):132-9. Unique Identifier : AIDSLINE MED/99182556; Smith KJ; Nelson A; Angritt P; Morz A; Skelton HG; National Naval Medical Center, Bethesda, Maryland 20089-5600,; USA.; BACKGROUND: Although all epidemiologic subsets of Kaposi s sarcoma (KS) (i.e., sporadic, endemic, epidemic, and iatrogenic) have an association with human herpes virus 8 (HHV8), these subsets occur in patient populations with distinctive clinical features. To a variable degree men outnumber women in all subsets. OBJEC
Crusted scabies in association with human T-cell lymphotropic virus 1 [clinical conference]: J Cutan Med Surg. 1999 Jan;3(3):148-52. Unique Identifier : AIDSLINE MED/99236439; Bergman JN; Dodd WA; Trotter MJ; Oger JJ; Dutz JP; Division of Dermatology, The University of British Columbia,; Vancouver, Canada.; BACKGROUND: Human T-cell lymphotropic virus I (HTLV- 1) infection can lead to myelopathy/tropical spastic paresis and adult T-cell leukemia/lymphoma (ATLL). Infection with HTLV-1 has also been associated with clinically significant immunosuppression. Crusted scabies, also known as Norwegian scabies, is an uncommon pre
[Summer-type hypersensitivity pneumonitis with remarkable obstructive impairment of pulmonary function]: Nihon Kokyuki Gakkai Zasshi. 1998 Dec;36(12):1048-52. Unique Identifier : AIDSLINE MED/99164354; Iwakami S; Shiina K; Owada A; Hasunuma K; Sato K; Takahashi H; Dambara T; Miyamoto H; Uekusa T; Fukuchi Y; Department of Respiratory Medicine, Juntendo University School of; Medicine, Tokyo, Japan.; A 57-year-old-man was admitted because of persistent cough and progressive dyspnea over a period of 2 months. Examination revealed wheezing in both lungs, severe hypoxemia, and marked obstructive impairment of pulmonary function. A chest CT scan showed diffuse small nodular lesions with patchy air space opacifications
Hyperimmunoglobin E syndrome: a sign of TH1/TH2 imbalance?: Eur J Dermatol. 1999 Mar;9(2):129-31. Unique Identifier : AIDSLINE MED/99167710; Shirafuji Y; Matsuura H; Sato A; Kanzaki H; Katayama H; Arata J; Department of Dermatology, Okayama University Medical School,; Shikata-cho 2-5-1, Okayama 700-8558, Japan.; We report on a patient with hyperimmunoglobulin E syndrome, who developed pruritic vesiculopapules from the age of six months and also had recurrent episodes of skin abscesses and oral thrush . Serum IgE was extremely elevated at 59,514 IU/ml and specific IgE antibody to Staphyl
Repeatability of surface EMG variables during voluntary isometric contractions of the biceps brachii muscle.: J Electromyogr Kinesiol. 1999 Apr;9(2):105-19. Unique Identifier : AIDSLINE MED/99196347; Rainoldi A; Galardi G; Maderna L; Comi G; Lo Conte L; Merletti R; Centro di Bioingegneria, USAS-Politecnico di Torino, ASLI-Regione; Piemonte, Italy.; The repeatability of initial value and rate of change of mean spectral frequency (MNF), average rectified values (ARV) and muscle fiber conduction velocity (CV) was investigated in the dominant biceps brachii of ten normal subjects during sustained isometric voluntary contractions. Four levels of contraction were stud
Terminal exon definition occurs cotranscriptionally and promotes termination of RNA polymerase II.: Mol Cell. 1999 Mar;3(3):371-8. Unique Identifier : AIDSLINE MED/99214852; Dye MJ; Proudfoot NJ; Sir William Dunn School of Pathology, University of Oxford,; United Kingdom.; Analysis of nascent transcription from the human epsilon- and beta-globin genes shows that transcriptional termination occurs within 1.5 kb of the poly(A) site and is dependent on the presence of functional poly(A) signals. Even so, transcripts that have not been cleaved at the poly(A) site are detected up to the term
Identification of a major latent nuclear antigen, LNA-1, in the human herpesvirus 8 genome.: J Hum Virol. 1997 Nov-Dec;1(1):19-29. Unique Identifier : AIDSLINE MED/99211131; Kellam P; Boshoff C; Whitby D; Matthews S; Weiss RA; Talbot SJ; Institute of Cancer Research, Chester Beatty Laboratories,; London, United Kingdom.; OBJECTIVES: Human herpesvirus 8 (HHV-8) is strongly associated with all forms of Kaposi s sarcoma (KS) and with primary effusion lymphomas (PEL). KS patients sera are immunoreactive against discrete nuclear localizing antigens in PEL cell lines. This study sought to identify and characterize these nuclear localizing
Gp120 sequence variation in brain and in T-lymphocyte human immunodeficiency virus type 1 primary isolates.: J Hum Virol. 1997 Nov-Dec;1(1):3-18. Unique Identifier : AIDSLINE MED/99211130; Gartner S; McDonald RA; Hunter EA; Bouwman F; Liu Y; Popovic M; Department of Neurology, Johns Hopkins University School of; Medicine, Baltimore, Maryland, USA.; OBJECTIVE: We sought to identify genetic determinants within human immunodeficiency virus type 1 (HIV-1) gp120 that differentiate viral species in brain from those in lymphocytes. STUDY DESIGN/METHODS: Polymerase chain reaction (PCR) was used to amplify gp120 genes from paired brain and T-cell isolates from two infant
Correlation of tumor suppressor P53 RNA expression with human immunodeficiency virus disease in rapid and slow progressors.: J Hum Virol. 1997 Nov-Dec;1(1):30-6. Unique Identifier : AIDSLINE MED/99211132; McLinden RJ; Lewis B; Michael NL; Redfield RR; Birx DL; Kim JH; Department of Medicine, University of Maryland, Baltimore, USA.; OBJECTIVE: To determine the relation between P53 tumor suppressor RNA expression and human immunodeficiency virus (HIV) disease progression. STUDY DESIGN/METHODS: A quantitative assay of P53 RNA expression was used to analyze a cohort of HIV-negative persons. The assay was then used in longitudinal and cross-sectional
Mother-to-child transmission of human T-cell lymphotropic virus type I associated with prolonged breast-feeding.: J Hum Virol. 1997 Nov-Dec;1(1):37-44. Unique Identifier : AIDSLINE MED/99211133; Wiktor SZ; Pate EJ; Rosenberg PS; Barnett M; Palmer P; Medeiros D; Maloney EM; Blattner WA; Viral Epidemiology Branch, National Cancer Institute, Bethesda,; Maryland 20816, USA.; OBJECTIVES: We assessed the risk of transmitting human T-cell lymphotropic virus type I (HTLV-I) through breast-feeding. STUDY DESIGN/METHODS: To assess the risk of mother-to-child transmission of HTLV-I, 212 HTLV-I-seropositive women and 145 HTLV-I-seronegative women were enrolled in a prospective cohort study conduc
Diagnostic challenges for rapid human immunodeficiency virus assays. Performance using HIV-1 group O, HIV-1 group M, and HIV-2 samples.: J Hum Virol. 1997 Nov-Dec;1(1):45-51. Unique Identifier : AIDSLINE MED/99211134; Constantine NT; Zekeng L; Sangare AK; Gurtler L; Saville R; Anhary H; Wild C; Institute of Human Virology, University of Maryland, Baltimore; 21201, USA. constant@umbi.umd.edu; OBJECTIVE: We sought to determine the ability of seven rapid assays for human immunodeficiency virus (HIV) to detect antibodies in a panel of sera from individuals infected with different types and groups of HIV. STUDY DESIGN/METHODS: Sixty-eight well-characterized samples, including HIV-1 group O (24), several HIV-1
Tat toxoid: its potential role as an HIV vaccine [editorial; comment]: J Hum Virol. 1998 May-Jun;1(4):249-50. Unique Identifier : AIDSLINE MED/99211152; Lambert J
Stimulation of bystander T-cell proliferation by tumor necrosis factor produced by HIV-1-infected macrophages.: J Hum Virol. 1998 May-Jun;1(4):257-66. Unique Identifier : AIDSLINE MED/99211154; Godard CM; Chermann JC; Unite de Recherche sur les Retrovirus et Maladies Associees,; Parc Scientifique et Technologique de Luminy, Marseille, France.; u322@inserm-nacre.univ-mrs.fr; OBJECTIVE: Cocultivation of the CD4+CD95+ T-cell line (MT4) with monocyte-derived macrophages (MDMs) infected with the HIV-1 resulted in costimulation of proliferation and apoptosis after 20 hours of contact. This study sought to determine whether tumor necrosis factor (TNF) produced by HIV-1-infected MDMs was involve
Antibodies to the HIV-1 Tat protein correlated with nonprogression to AIDS: a rationale for the use of Tat toxoid as an HIV-1 vaccine [see comments]: J Hum Virol. 1998 May-Jun;1(4):282-92. Unique Identifier : AIDSLINE MED/99211157; Zagury JF; Sill A; Blattner W; Lachgar A; Le Buanec H; Richardson M; Rappaport J; Hendel H; Bizzini B; Gringeri A; Carcagno M; Criscuolo M; Burny A; Gallo RC; Zagury D; Universite Pierre et Marie Curie, Paris, France.; OBJECTIVES: To investigate which immune parameters, such as antibodies against HIV-1 specificities, or viral parameters, such as p24 antigenemia, are predictive of disease progression. STUDY DESIGN: We performed studies on serum collected from individuals exhibiting two extremes of disease evolution--67 fast progresso
Safety and immunogenicity of HIV-1 Tat toxoid in immunocompromised HIV-1-infected patients [see comments]: J Hum Virol. 1998 May-Jun;1(4):293-8. Unique Identifier : AIDSLINE MED/99211158; Gringeri A; Santagostino E; Muca-Perja M; Mannucci PM; Zagury JF; Bizzini B; Lachgar A; Carcagno M; Rappaport J; Criscuolo M; Blattner W; Burny A; Gallo RC; Zagury D; Hemophilia and Thrombosis Center Angelo Bianchi Bonomi, IRCCS; Maggiore Hospital, Milan, Italy. hemophilia_ctr@polic.cilea.it; OBJECTIVES: To antagonize the deleterious effects of the HIV-1 toxin extracellular Tat on uninfected immune cells, we developed a new strategy of anti-HIV-1 vaccine using an inactivated but immunogenic Tat (Tat toxoid). Tat toxoid has been assayed for safety and immunogenicity in seropositive patients. METHOD: The pha
Prevalence of a CCR5 gene 32-bp deletion in an Israeli cohort of HIV-1-infected and uninfected hemophilia patients.: J Hum Virol. 1998 May-Jun;1(4):299-301. Unique Identifier : AIDSLINE MED/99211159; Kantor R; Barzilai A; Varon D; Martinowitz U; Gershoni JM; Department of Internal Medicine E, Chaim Sheba Medical Center,; Tel-Hashomer, Israel. kantora@agri.huji.ac.il; OBJECTIVE: The recently discovered connection of chemokines and their receptors to HIV pathogenesis, and the description of the 32-bp deletion in the CCR5 gene (delta 32 CCR5), led to heightened excitement and numerous reports regarding their role in HIV transmission and disease progression. The populations in most of
HTLV-I serostatus of mothers of patients with adult T-cell leukemia and HTLV-I-associated myelopathy/tropical spastic paraparesis.: J Hum Virol. 1998 May-Jun;1(4):302-5. Unique Identifier : AIDSLINE MED/99211160; Bartholomew C; Jack N; Edwards J; Charles W; Corbin D; Cleghorn FR; Blattner WA; University of the West Indies, Department of Medicine, Port of; Spain, Trinidad.; OBJECTIVES: It has been shown that > 90% of mothers of HTLV-I-infected children were themselves carriers of HTLV-I. This study was designed to determine the HTLV-I serostatus of mothers of patients with adult T-cell leukemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and to assess t
Evaluation of molecular parameters for routine assessment of viremia in patients with chronic hepatitis C who are undergoing antiviral therapy.: J Hum Virol. 1998 Jul-Aug;1(5):314-9. Unique Identifier : AIDSLINE MED/99211162; Kessler HH; Pierer K; Santner BI; Vellimedu SK; Stelzl E; Marth E; Fickert P; Stauber RE; Division of Clinical Molecular Diagnostics,; Karl-Franzens-University, Graz, Austria.; harald.kessler@kfunigraz.ac.at; OBJECTIVE: To define the usefulness of molecular parameters in patients with chronic hepatitis C who are undergoing antiviral therapy. Anti-hepatitis C virus (HCV) treatment was monitored by determination of serum HCV load and by presence of HCV RNA in peripheral blood mononuclear cells (PBMCs). STUDY DESIGN/METHODS:
HIV-1 nef mutations and clinical long-term nonprogression. A molecular epidemiology study.: J Hum Virol. 1998 Jul-Aug;1(5):320-7. Unique Identifier : AIDSLINE MED/99211163; Visco-Comandini U; Yun Z; Paganelli R; Orlandi P; Salotti A; Johansson B; Vahlne A; Sonnerborg A; Department of Immunology, Microbiology, Pathology and Infectious; Diseases, Karolinska Institute, Huddinge Hospital, Sweden.; UBVI@labd01.hs.sll.se; OBJECTIVES: To analyze HIV-1 nef gene mutations in a cohort of Italian and Swedish long-term nonprogressors (LTNP) and to investigate whether particular amino acid substitutions are associated with LTNP. STUDY DESIGN/METHODS: nef alleles from 21 LTNP and 8 progressor controls were amplified by polymerase chain reactio
Milk-borne transmission of HIV. Characterization of productively infected cells in breast milk and interactions between milk and saliva.: J Hum Virol. 1998 Jul-Aug;1(5):328-37. Unique Identifier : AIDSLINE MED/99211164; Southern SO; Department of Microbiology, University of Minnesota, Minneapolis; 55455, USA. sarka@lenti.med.umn.edu; OBJECTIVES: Definition of the cellular constituents of breast milk and infant saliva that are involved in milk-borne transmission of HIV infectivity. STUDY DESIGN/METHODS: Productively infected cells in colostrum and milk of HIV-1-seropositive mothers were identified by in situ hybridization and immunocytochemistry. A
Effect of splenectomy on T-cell subsets and plasma HIV viral titers in HIV-infected patients.: J Hum Virol. 1998 Jul-Aug;1(5):338-45. Unique Identifier : AIDSLINE MED/99211165; Bernard NF; Chernoff DN; Tsoukas CM; Immunodeficiency Treatment Center, McGill University Medical; Center, Montreal, Quebec, Canada. MCTL@musica.mcgill.ca; OBJECTIVE: In previous studies we have shown that removal of the spleen in HIV-infected people during the asymptomatic phase of disease results in slower time to AIDS and may also result in improved survival. In this paper, we examine whether splenectomy affects lymphocyte counts, T-cell subsets, and HIV plasma viremi
Transduction of CD34+ cells by a vesicular stomach virus protein G (VSV-G) pseudotyped HIV-1 vector. Stable gene expression in progeny cells, including dendritic cells.: J Hum Virol. 1998 Jul-Aug;1(5):346-52. Unique Identifier : AIDSLINE MED/99211166; Li X; Mukai T; Young D; Frankel S; Law P; Wong-Staal F; Department of Medicine, University of California, San Diego, La; Jolla, USA. fwongstaal@ucsd.edu; OBJECTIVE: To use HIV-1 vectors to mediate stable gene transfer into hematopoietic stem/progenitor cells. STUDY DESIGN/METHODS: Purified human CD34+ cells were transduced with HIV-1 vectors pseudotyped with VSV-G and subjected to colony-forming assays and differentiation in liquid culture. Transduction was determined
State of the HIV pandemic [editorial]: J Hum Virol. 1998 Nov-Dec;1(7):427-9. Unique Identifier : AIDSLINE MED/99211167; Essex M
Histone-mediated transfer and expression of the HIV-1 tat gene in Jurkat cells.: J Hum Virol. 1998 Nov-Dec;1(7):430-40. Unique Identifier : AIDSLINE MED/99211168; Demirhan I; Hasselmayer O; Chandra A; Ehemann M; Chandra P; Gustav-Embden Center of Biological Chemistry, Department of; Molecular Biology, Frankfurt University Medical School, Germany.; We studied the gene transfer efficiency of lipofection reagents in comparison to DEAE-Dextran. DOTAP, Dosper, and Lipofectin have lower transfection efficiency; Lipofectamine has a 2.5-fold better efficiency compared with DEAE-Dextran. We report a novel and highly efficient DNA transfer system based on the DNA-binding
Involvement of protein-DNA interaction in adeno-associated virus Rep78-mediated inhibition of HIV-1.: J Hum Virol. 1998 Nov-Dec;1(7):441-50. Unique Identifier : AIDSLINE MED/99211169; Kokorina NA; Santin AD; Li C; Hermonat PL; Department of Obstetrics and Gynecology, University of Arkansas; for Medical Sciences, Little Rock 72205, USA.; OBJECTIVE: It has been well documented by several laboratories that adeno-associated virus (AAV) is able to inhibit HIV-1 replication and gene expression. This effect has been mapped to the AAV-encoded Rep78 protein. However, the mechanism by which Rep78 is able to inhibit HIV-1 is unclear. As Rep78 is a DNA binding t
Fast genotypic detection of drug resistance mutations in the HIV-1 reverse transcriptase gene of treatment-naive patients.: J Hum Virol. 1998 Nov-Dec;1(7):451-6. Unique Identifier : AIDSLINE MED/99211170; Fontaine E; Lambert C; Servais J; Ninove D; Plesseria JM; Staub T; Arendt V; Kirpach P; Robert I; Schneider F; Hemmer R; Schmit JC; Laboratoire de Retrovirologie, Centre de Recherche; Public-Sante, Luxembourg.; OBJECTIVES: This study was performed to assess the frequency of drug resistance mutations in treatment-naive HIV-1-infected patients. STUDY DESIGN/METHODS: Frozen plasma samples from 135 treatment-naive HIV-infected adults were available from the first time the patients were seen for their infection in our center betw
Low peripheral blood viral HIV-2 RNA in individuals with high CD4 percentage differentiates HIV-2 from HIV-1 infection.: J Hum Virol. 1998 Nov-Dec;1(7):457-68. Unique Identifier : AIDSLINE MED/99211171; Berry N; Ariyoshi K; Jaffar S; Sabally S; Corrah T; Tedder R; Whittle H; Department of Virology, Windeyer Institute of Medical Sciences,; University College London Medical School, U.K.; OBJECTIVES: To elucidate why the virulence of HIV-1 and HIV-2 infections differ in West African populations. STUDY DESIGN/METHOD: Peripheral blood plasma virion RNA and cellular proviral DNA levels were measured in a cross-section of 59 HIV-1 and 49 HIV-2 singly infected individuals representing all stages of infectio
Role of the CCR5 delta 32 allele in resistance to HIV-1 infection in west Africa.: J Hum Virol. 1998 Nov-Dec;1(7):469-74. Unique Identifier : AIDSLINE MED/99211172; Kokkotou E; Philippon V; Gueye-Ndiaye A; Mboup S; Wang WK; Essex M; Kanki P; Department of Immunology and Infectious Diseases, Harvard School; of Public Health, Boston, Massachusetts 02115-6017, USA.; OBJECTIVE: To determine the frequency of the mutant CCR5 delta 32 allele in high-risk HIV-seronegative Africans as compared with the general African population, and to assess its in vitro protective efficacy against HIV-1 infection. STUDY DESIGN: In the homozygous form, the CCR5 delta 32 allele confers resistance to m
TORCH testing in HIV-infected women.: Clin Obstet Gynecol. 1999 Mar;42(1):149-62; quiz 174-5. Unique Identifier : AIDSLINE MED/99172963; Helfgott A; Department of Obstetrics and Gynecology, University of; Texas-Houston Medical School, LBJ Hospital 77026, USA.; The issue of TORCH testing in pregnant women infected with the HIV virus remains confusing, even more so than it is in the non-HIV-infected gravida. Unfortunately, the data presented in this article make the recommendations of how to test for these various infections in pregnancy that much more difficult. Patients who
[Serial MRI findings in patients with CNS cryptococcosis]: Unique Identifier : AIDSLINE MED/99177762; Kumazawa K; Yamada T; Nakamori T; Hoshino A; Terao S; Mitsuma T; We reported the serial magnetic resonance imaging (MRI) findings of two patients with central nervous system (CNS) cryptococcal infection without AIDS. The diagnosis of CNS cryptococcosis was made by visualizing the fungi in the CSF with the India ink test, detecting cryptococcal an
[Antigenicity of nine synthetic peptides of human immunodeficiency virus]: Chung Hua Nei Ko Tsa Chih. 1997;36(2):105-7. Unique Identifier : AIDSLINE MED/99029113; Mao P; He H; Hong S; Department of Virology, 302 Hospital of PLA, Beijing.; To establish a ELISA method to detect the infection of human immunodeficiency virus (HIV), we synthesized nine peptides ranging in length between 10-27 amino acid (aa) of HIV located in the regions of gp41, p24 of HIV-1 and gp36 of HIV-2, according to the published amino acid sequence and the position of antigenic det
[German-Austrian recommendations for post-exposure prophylaxis after HIV infection (letter)]: Dtsch Med Wochenschr. 1999 Mar 26;124(12):373. Unique Identifier : AIDSLINE MED/99230989; Seuffer RH
Structural basis for the specificity of the initiation of HIV-1 reverse transcription.: EMBO J. 1999 Feb 15;18(4):1038-48. Unique Identifier : AIDSLINE MED/99146920; Isel C; Westhof E; Massire C; Le Grice SF; Ehresmann B; Ehresmann C; Marquet R; Unite Propre de Recherche No. 9002 du Centre National de la; Recherche Scientifique, Institut de Biologie Moleculaire et; Cellulaire, 15 rue Rene Descartes, 67084 Strasbourg Cedex,; France.; Initiation of human immunodeficiency virus type 1 (HIV-1) reverse transcription requires specific recognition of the viral genome, tRNA3Lys, which acts as primer, and reverse transcriptase (RT). The specificity of this ternary complex is mediated by intricate interactions between HIV-1 RNA and tRNA3Lys, but remains po
Head-to-tail dimers and interdomain flexibility revealed by the crystal structure of HIV-1 capsid protein (p24) complexed with a monoclonal antibody Fab.: EMBO J. 1999 Mar 1;18(5):1124-36. Unique Identifier : AIDSLINE MED/99164080; Berthet-Colominas C; Monaco S; Novelli A; Sibai G; Mallet F; Cusack S; European Molecular Laboratory Biology, Grenoble Outstation,; B.P.156X, F-38042 Grenoble Cedex 9, France.; The crystal structure of an intact molecule of HIV-1 capsid protein (p24) in complex with a monoclonal antibody fragment recognizing an epitope on the C-terminal domain has been determined at 3 A resolution. The helical N- and C-terminal domains of p24 are linked by an extended peptide forming a flexibly linked dumb-b
Stimulation of Tat-associated kinase-independent transcriptional elongation from the human immunodeficiency virus type-1 long terminal repeat by a cellular enhancer.: EMBO J. 1999 Mar 1;18(5):1378-86. Unique Identifier : AIDSLINE MED/99164103; West MJ; Karn J; Medical Research Council, Laboratory of Molecular Biology, Hills; Road, Cambridge, CB2 2QH, UK.; The human immunodeficiency virus type-1 (HIV-1) long terminal repeat (LTR) initiates transcription efficiently but produces only short transcripts in the absence of the trans-activator protein, Tat. To determine whether a cellular enhancer could provide the signals required to recruit an elongation-competent polymeras
Intracellular degradation of the HIV-1 envelope glycoprotein. Evidence for, and some characteristics of, an endoplasmic reticulum degradation pathway.: Eur J Biochem. 1999 Mar;260(2):482-9. Unique Identifier : AIDSLINE MED/99195489; Courageot J; Fenouillet E; Bastiani P; Miquelis R; Laboratoire de Biochimie, Ingenierie des Proteines, Institut; Federatif Jean Roche, Faculte de Medecine-Nord, Marseille,; France.; Analysis of the fate of HIV-1 envelope protein gp160 (Env) has shown that newly synthesized proteins may be degraded within the biosynthetic pathway and that this degradation may take place in compartments other than the lysosomes. The fate of newly synthesized Env was studied in living BHK-21 cells with the recombina
Increased discriminative stimulus potency of phencyclidine in C57B1/6 mice infected with the LP-BM5 retrovirus.: Eur J Pharmacol. 1999 Feb 12;367(1):1-5. Unique Identifier : AIDSLINE MED/99180294; English JA; Bruce KH; Paul IA; Department of Psychiatry, University of Mississippi Medical; Center, Jackson 39216-4505, USA.; Drug discrimination procedures in mice are used to study the neuropharmacology of a wide variety of drugs. In C57 B1/6 mice, infection with the LP-BM5 murine leukemia virus leads to a syndrome (murine acquired immunodeficiency syndrome-MAIDS) characterized by immunocompromise, neurochemical alterations, and learning a
Impact of chronic liver disease due to hepatitis viruses as cause of hospital admission and death in HIV-infected drug users.: Eur J Epidemiol. 1999 Jan;15(1):1-4. Unique Identifier : AIDSLINE MED/99196624; Soriano V; Garcia-Samaniego J; Valencia E; Rodriguez-Rosado R; Munoz F; Gonzalez-Lahoz J; Service of Infectious Diseases, Centro de Investigaciones; Clinicas, Instituto de Salud Carlos III, Madrid, Spain.; vsoriano@dragonet.es; The life expectancy of HIV-positive individuals has been prolonged in recent years, as a consequence of the wide use of antiretroviral drugs and primary prophylaxis for the most common opportunistic infections. In HIV-positive persons infected parenterally, chronic viral liver disease (CVLD), mainly that caused by hep
When do HIV-infected persons start with antiretroviral therapy? A retrospective analysis of patients' monitoring and treatment status in general practice, as compared with the 1991 Dutch HIV treatment guidelines.: Fam Pract. 1998 Dec;15(6):525-8. Unique Identifier : AIDSLINE MED/99176677; Reedijk M; Wigersma L; Mohrs J; OBJECTIVE: We aimed to compare, in a sample of Amsterdam general practices, the monitoring and treatment status of HIV-infected patients according to the 1991 Dutch consensus guidelines for antiretroviral treatment of HIV-infection, which advise that therapy be started at a peripheral blood CD4+ cell count of
Phase variations of the Mycoplasma penetrans main surface lipoprotein increase antigenic diversity.: Infect Immun. 1999 Apr;67(4):1569-78. Unique Identifier : AIDSLINE GENBANK/AJ006699; Neyrolles O; Chambaud I; Ferris S; Prevost MC; Sasaki T; Montagnier L; Blanchard A; Unite d'Oncologie Virale, Institut Pasteur, 75724 Paris Cedex; 15, France.; Mycoplasma penetrans is a recently identified mycoplasma, isolated from urine samples collected from human immunodeficiency virus (HIV)-infected patients. Its presence is significantly associated with HIV infection. The major antigen recognized during natural and experimental infections is an abundant P35 lipoprotein
Interleukin-10 and antigen-presenting cells actively suppress Th1 cells in BALB/c mice infected with the filarial parasite Brugia pahangi.: Unique Identifier : AIDSLINE MED/99184976; Osborne J; Devaney E; Infection with the third-stage larvae (L3) of the filarial nematode Brugia results in a Th2-biased immune response in mice and humans. Previously we have shown that the production of interleukin 4 (IL-4) is critical for down-regulating polyclonal Th1 responses in L3-infected mice. However, the in vitro neutralization
Interleukin-12 production is required for chlamydial antigen-pulsed dendritic cells to induce protection against live Chlamydia trachomatis infection.: Infect Immun. 1999 Apr;67(4):1763-9. Unique Identifier : AIDSLINE MED/99185000; Lu H; Zhong G; Molecular Immunology Section, Department of Medical Microbiology,; University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada.; Immunization with dendritic cells pulsed ex vivo with antigens has been successfully used to elicit primary antigen-specific immune responses. We report that mouse bone marrow-derived dendritic cells pulsed with inactivated chlamydial organisms induced strong protection against live chlamydial infection in a mouse lun
Role of gamma interferon in cellular immune response against murine Encephalitozoon cuniculi infection.: Infect Immun. 1999 Apr;67(4):1887-93. Unique Identifier : AIDSLINE MED/99185016; Khan IA; Moretto M; Department of Medicine and Microbiology, Dartmouth Medical; School, Lebanon, New Hampshire 03756, USA.; Imtiaz.Khan@dartmouth.edu; Microsporidia are obligate intracellular protozoan parasites that cause a wide variety of opportunistic infection in patients with AIDS. Because it is able to grow in vitro, Encephalitozoon cuniculi is currently the best-studied microsporidian. T cells mediate protective immunity against this parasite. Splenocytes obt
Geographical clustering of human T-cell lymphotropic virus type I in Guadeloupe, an endemic Caribbean area.: Int J Cancer. 1999 May 5;81(3):330-4. Unique Identifier : AIDSLINE MED/99224650; Rouet F; Rabier R; Foucher C; Chancerel B; Agis F; Strobel M; Etablissement de Transfusion Sanguine, Hopital Ricou,; Pointe-a-Pitre, Guadeloupe, France.; Between January 1989 and December 1996, 59,426 blood donors from Guadeloupe (French West Indies) were screened for antibodies to human T-cell lymphotropic virus type I (HTLV-I). Of these, 195 were confirmed as being positive for HTL
Interleukin-12-secreting human papillomavirus type 16-transformed cells provide a potent cancer vaccine that generates E7-directed immunity.: Int J Cancer. 1999 May 5;81(3):428-37. Unique Identifier : AIDSLINE MED/99224664; Hallez S; Detremmerie O; Giannouli C; Thielemans K; Gajewski TF; Burny A; Leo O; Departement de Biologie Moleculaire, Universite Libre de; Bruxelles, Rhode-St Genese, Belgium. shallez@dbm.ulb.ac.be; The development of a vaccine that would be capable of preventing or curing the (pre)cancerous lesions induced by genital oncogenic human papillomaviruses (HPVs) is the focus of much research. Many studies are presently evaluating vaccines based on the viral E6 and E7 oncoproteins, both of which are continually express
[An important task even in the HAART era (High Activity Anti-Retroviral Therapy). Infection management in HIV-patients]: Internist (Berl). 1999 Mar;40(3 Suppl Infektions):1-4. Unique Identifier : AIDSLINE MED/99219007
Access and use of medications in HIV disease.: Health Serv Res. 1999 Apr;34(1 Pt 1):123-44. Unique Identifier : AIDSLINE MED/99216038; Smith SR; Kirking DM; University of North Carolina School of Pharmacy, Division of; Pharmaceutical Policy and Evaluative Sciences, Chapel Hill; 27599-7360, USA.; OBJECTIVE: To examine if measures of access to medical care are associated with outpatient use of antiretroviral and Pneumocystis carinii pneumonia (PCP) medications among a cohort of individuals with HIV disease. DATA SOURCES: Adults who participated in a series of up to six interviews as part of the AIDS Costs and S
Conditional Length of Stay.: Health Serv Res. 1999 Apr;34(1 Pt 2):349-63. Unique Identifier : AIDSLINE MED/99213772; Silber JH; Rosenbaum PR; Koziol LF; Sutaria N; Marsh RR; Even-Shoshan O; Center for Outcomes Research, Children's Hospital of; Philadelphia, PA 19104-4318, USA.; OBJECTIVE: To develop and test a new outcome measure, Conditional Length of Stay (CLOS), to assess hospital performance when deaths are rare and complication data are not available. DATA SOURCES: The 1991 and 1992 MedisGroups National Comparative Data Base. STUDY DESIGN: We use engineering reliability theory tradition
Activation of serum response factor by RhoA is mediated by the nuclear factor-kappaB and C/EBP transcription factors.: J Biol Chem. 1999 Mar 26;274(13):8506-15. Unique Identifier : AIDSLINE MED/99185067; Montaner S; Perona R; Saniger L; Lacal JC; Instituto de Investigaciones Biomedicas, Consejo Superior de; Investigaciones Cientificas, Madrid, Spain.; The activity of the transcription factor NF-kappaB can be modulated by members of the Rho family of small GTPases (Perona, R., Montaner, S., Saniger, L., Sanchez-Perez, I., Bravo, R., and Lacal, J. C. (1997) Genes Dev. 11, 463-475). Ectopic expression of RhoA, Rac1, and Cdc42Hs proteins induces the translocation of NF
Leukotriene binding, signaling, and analysis of HIV coreceptor function in mouse and human leukotriene B4 receptor-transfected cells.: J Biol Chem. 1999 Mar 26;274(13):8597-603. Unique Identifier : AIDSLINE MED/99185079; Martin V; Ronde P; Unett D; Wong A; Hoffman TL; Edinger AL; Doms RW; Funk CD; Center for Experimental Therapeutics, University of Pennsylvania,; Philadelphia, Pennsylvania 19104, USA.; The mouse leukotriene B4 receptor (m-BLTR) gene was cloned. Membrane fractions of human embryonic kidney 293 cells stably expressing m-BLTR demonstrated a high affinity and specific binding for leukotriene B4 (LTB4, Kd = 0.24 +/- 0.03 nM). In competition binding experiments, LTB4 was the most potent competitor (Ki = 0
Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.: J Biol Chem. 1999 Mar 26;274(13):8875-85. Unique Identifier : AIDSLINE MED/99185115; Oppermann M; Mack M; Proudfoot AE; Olbrich H; Department of Immunology, University of Gottingen, 37075; Gottingen, Germany. mopperm@gwdg.de; The binding of CC chemokines to CC chemokine receptor 5 (CCR5) triggers cellular responses that, generally, are only transient in nature. To explore the potential role of G protein-coupled receptor kinases (GRKs) in the regulation of CCR5, we performed phosphorylation experiments in a rat basophilic leukemia cell line
Incorporation of Vpr into human immunodeficiency virus type 1 requires a direct interaction with the p6 domain of the p55 gag precursor.: J Biol Chem. 1999 Mar 26;274(13):9083-91. Unique Identifier : AIDSLINE MED/99185142; Bachand F; Yao XJ; Hrimech M; Rougeau N; Cohen EA; Laboratoire de retrovirologie humaine, Departement de; Microbiologie et Immunologie, Faculte de Medecine, Universite; de Montreal, Montreal, Quebec H3C 3J7, Canada.; The 96-amino acid Vpr protein is the major virion-associated accessory protein of the human immunodeficiency virus type 1 (HIV-1). As Vpr is not part of the p55 Gag polyprotein precursor (Pr55(gag)), its incorporation requires an anchor to associate with the assembling viral particles. Although the molecular mechanism
Identification of peroxisomal acyl-CoA thioesterases in yeast and humans.: J Biol Chem. 1999 Apr 2;274(14):9216-23. Unique Identifier : AIDSLINE GENBANK/AF124265; Jones JM; Nau K; Geraghty MT; Erdmann R; Gould SJ; Department of Biological Chemistry, The Johns Hopkins University; School of Medicine, Baltimore, Maryland 21205, USA.; A computer-based screen of the Saccharomyces cerevisiae genome identified YJR019C as a candidate oleate-induced gene. YJR019C mRNA levels were increased significantly during growth on fatty acids, suggesting that it may play a role in fatty acid metabolism. The YJR019C product is highly similar to tesB, a bacterial ac
Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function.: J Biol Chem. 1999 Apr 2;274(14):9617-26. Unique Identifier : AIDSLINE MED/99194814; Lee B; Sharron M; Blanpain C; Doranz BJ; Vakili J; Setoh P; Berg E; Liu G; Guy HR; Durell SR; Parmentier M; Chang CN; Price K; Tsang M; Doms RW; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia, Pennsylvania 19104, USA.; The chemokine receptor CCR5 is the major coreceptor for R5 human immunodeficiency virus type-1 strains. We mapped the epitope specificities of 18 CCR5 monoclonal antibodies (mAbs) to identify domains of CCR5 required for chemokine binding, gp120 binding, and for inducing conformational changes in Env that lead to memb
Altered expression profile of the surface glycopeptidolipids in drug-resistant clinical isolates of Mycobacterium avium complex.: J Biol Chem. 1999 Apr 2;274(14):9778-85. Unique Identifier : AIDSLINE MED/99194833; Khoo KH; Jarboe E; Barker A; Torrelles J; Kuo CW; Chatterjee D; Institute of Biological Chemistry, Academia Sinica, Nankang,; Taipei 115, Taiwan, Republic of China.; Members of the Mycobacterium avium complex are the most frequently encountered opportunistic bacterial pathogens among patients in the advanced stage of AIDS. Two clinical isolates of the same strain, numbers 397 and 417, were obtained from an AIDS patient with disseminated M. avium complex infection before and after
Pharmacokinetics and tolerability of intravenous trecovirsen (GEM 91), an antisense phosphorothioate oligonucleotide, in HIV-positive subjects.: J Clin Pharmacol. 1999 Jan;39(1):47-54. Unique Identifier : AIDSLINE MED/99142173; Sereni D; Tubiana R; Lascoux C; Katlama C; Taulera O; Bourque A; Cohen A; Dvorchik B; Martin RR; Tournerie C; Gouyette A; Schechter PJ; Service de Medecine Interne, Hopital Cochin, Paris, France.; Trecovirsen, a 25-mer antisense phosphorothioate oligonucleotide targeted at the gag site of the HIV gene, was administered to HIV-positive volunteers as an i.v. infusion. Single doses ranged from 0.1 to 2.5 mg/kg in an ascending escalation in cohorts of 6 to 12 subjects. Plasma trecovirsen concentrations and pharmaco
Sexual behavior and AIDS-related knowledge among community college students in Orange County, California.: J Community Health. 1999 Feb;24(1):29-43. Unique Identifier : AIDSLINE MED/99155671; Shapiro J; Radecki S; Charchian AS; Josephson V; College of Medicine, University of California, Irvine, USA.; Whereas college students are not identified as a high-risk group for acquiring the HIV infection, they exhibit high-risk behaviors consistent with their age group, including multiple sexual partners and high rates of unprotected intercourse. This study was conducted to determine levels of HIV-related sexual behavior,
Soluble tumor necrosis factor receptors in chronic hepatitis C: a correlation with histological fibrosis and activity.: J Hepatol. 1999 Feb;30(2):185-91. Unique Identifier : AIDSLINE MED/99165463; Zylberberg H; Rimaniol AC; Pol S; Masson A; De Groote D; Berthelot P; Bach JF; Brechot C; Zavala F; Unite d'Hepatologie, Hopital Necker, Paris, France.; BACKGROUND/AIMS: Tumor necrosis factor-alpha (TNF) is a mediator of inflammation and cellular immune response. Soluble TNF receptors (sTNFR) sTNF-R55 and sTNF-R75, which compete with cellular receptors for the binding of TNF, have been detected at high levels in infectious diseases including human immunodeficiency vir
Retrospective analysis of the impact of HIV infection and alcohol use on chronic hepatitis C in a large cohort of drug users [letter]: Unique Identifier : AIDSLINE MED/99165489; Bonacini M
HIV-1-induced neuronal injury in the developing brain.: J Leukoc Biol. 1999 Apr;65(4):453-7. Unique Identifier : AIDSLINE MED/99219267; Epstein LG; Gelbard HA; Department of Neurology, University of Rochester, New York, USA.; L-epstein@nwu.edu; HIV-1 infection of the nervous system causes neuronal injury and death, resulting in cognitive, motor, and behavioral dysfunction in both adults and children. In infants a characteristic feature of HIV-1 infection is impaired brain growth resulting in secondary microcephaly with onset between 2 and 4 months of age. Th
Molecular pathway involved in HIV-1-induced CNS pathology: role of viral regulatory protein, Tat.: J Leukoc Biol. 1999 Apr;65(4):458-65. Unique Identifier : AIDSLINE MED/99219268; Rappaport J; Joseph J; Croul S; Alexander G; Del Valle L; Amini S; Khalili K; Center for NeuroVirology and NeuroOncology, MCP Hahnemann; University, Philadelphia, Pennsylvania 19102, USA.; The broad range of histological lesions associated with HIV-1 are somewhat subtle relative to the clinical manifestations that occur as a result of HIV infection. Although it is clear that HIV has a causative role in CNS disease, dementia appears to be a consequence of the infiltra
The SIV-infected rhesus monkey model for HIV-associated dementia and implications for neurological diseases.: J Leukoc Biol. 1999 Apr;65(4):466-74. Unique Identifier : AIDSLINE MED/99219269; Rausch DM; Murray EA; Eiden LE; Office of AIDS Research, National Institute of Mental Health,; Bethesda, Maryland 20892-9623, USA. dr89b@nih.gov; The neuropathogenesis of human immunodeficiency virus (HIV)-associated dementia has remained elusive, despite identification of HIV as the causal agent. Although a number of contributing factors have been identified, the series of events that culminate in motor and cognitive impair
Do alcohol and cocaine abuse alter the course of HIV-associated dementia complex?: J Leukoc Biol. 1999 Apr;65(4):475-81. Unique Identifier : AIDSLINE MED/99219270; Tyor WR; Middaugh LD; Department of Neurology, Medical University of South Carolina,; Charleston 29425, USA. tyorwr@musc.edu; Although psychoactive drugs are commonly used by AIDS patients, it is unclear whether commonly abused drugs, such as cocaine and ethanol, affect the course of HIV-associated dementia (HADC). Epidemiological studies have resulted in conflicting conclusions as to what role, if any, a
Proton magnetic resonance spectroscopy pattern of progressive multifocal leukoencephalopathy in AIDS.: J Neurol Neurosurg Psychiatry. 1999 Apr;66(4):520-3. Unique Identifier : AIDSLINE MED/99215611; Iranzo A; Moreno A; Pujol J; Marti-Fabregas J; Domingo P; Molet J; Ris J; Cadafalch J; Department of Neurology, Santa Creu i Sant Pau Hospital,; Autonomous University of Barcelona, Spain.; The objective was to determine whether the use of intermediate echo times (135 ms) in proton magnetic resonance spectroscopy (1H-MRS) detects a homogenous pattern in progressive multifocal leukoencephalopathy (PML) in HIV-1 infected people, and to confirm the results of previous studies. Six patients infected with HIV
Hypothesis on the pathogenesis of vacuolar myelopathy, dementia, and peripheral neuropathy in AIDS [letter]: J Neurol Neurosurg Psychiatry. 1999 Apr;66(4):554. Unique Identifier : AIDSLINE MED/99215628; Di Rocco A; Werner P
A molecular-field-based similarity study of non-nucleoside HIV-1 reverse transcriptase inhibitors.: J Comput Aided Mol Des. 1999 Jan;13(1):79-93. Unique Identifier : AIDSLINE MED/99187466; Mestres J; Rohrer DC; Maggiora GM; Pharmacia & Upjohn Inc., Kalamazoo, MI 49001, USA.; This article describes a molecular-field-based similarity method for aligning molecules by matching their steric and electrostatic fields and an application of the method to the alignment of three structurally diverse non-nucleoside HIV-1 reverse transcriptase inhibitors. A brief description of the method, as implemen
Prevalence of Helicobacter pylori infection detected by serology and 13C-urea breath test in HIV-1 perinatally infected children.: J Pediatr Gastroenterol Nutr. 1999 Mar;28(3):301-6. Unique Identifier : AIDSLINE MED/99165055; Lionetti P; Amarri S; Silenzi F; Galli L; Cellini M; de Martino M; Vierucci A; Dipartimento di Pediatria Universita di Firenze, Italy.; BACKGROUND: Conflicting results have been reported in adults with human immunodeficiency virus (HIV-1) who were investigated for Helicobacter pylori infection. Most studies indicate a lower prevalence than is found in the general population. The purposes of this study were to evaluate H. pylori prevalence by noninvasi
Cyclosporine for rectoperineal fistula in a human immunodeficiency virus-infected child.: J Pediatr Gastroenterol Nutr. 1999 Mar;28(3):333-5. Unique Identifier : AIDSLINE MED/99165063; Caselli D; Maccabruni A; Beluffi G; Minoli L; Department of Paediatrics, University of Pavia, Istituto di; Ricovero e Cura a Carattere Scientifico Policlinico S. Matteo,; Italy.
The role of the iminium bond in the inhibition of reverse transcriptase by quaternary benzophenanthridines.: J Pharm Pharmacol. 1998 Nov;50(11):1307-15. Unique Identifier : AIDSLINE MED/99093146; Kerry MA; Duval O; Waigh RD; Mackay SP; School of Health Sciences, University of Sunderland, Tyne and; Wear, UK.; The quaternary benzo[c]phenanthridines fagaronine, nitidine and O-methylfagaronine have been reviewed as potential antitumour and antiviral agents. Their mode of action has not been established, but their ability to bind with DNA by intercalation is believed to be involved. Of the three synthetic analogues of O-methyl
Anti-HIV activity and mechanism of action of macrocyclic diamide SRR-SB3.: J Pharm Pharmacol. 1998 Dec;50(12):1339-42. Unique Identifier : AIDSLINE MED/99160211; Mahmood N; Jhaumeer-Lauloo S; Sampson J; Houghton PJ; The Centre for Bioactivity Screening of Natural Products,; Department of Pharmacy, King's College London, UK.; The importance of cyclic compounds as anti-cancer and anti-viral agents has been recognized for some time. We have studied a series of macrocyclic amide derivatives for activity against HIV infection of T lymphocytes in-vitro. Compounds containing aromatic rings and sulphur atoms were generally active, however the sel
Anxiety and depression among HIV-infected heterosexuals--a report from India.: J Psychosom Res. 1998 Nov;45(5):401-9. Unique Identifier : AIDSLINE MED/99050897; Chandra PS; Ravi V; Desai A; Subbakrishna DK; Department of Psychiatry, National Institute of Mental Health &; Neurosciences, Bangalore, India. chandra@nimhans.ren.nic.in; The aim of the study was to study factors related to anxiety, depression, and suicidal ideation among HIV-seropositive heterosexuals soon after being tested for their HIV status for the first time. Anxiety, depression, and suicidal ideation were assessed among 51 HIV-seropositive heterosexual men and women with variou
Asymmetric recognition of psoralen interstrand crosslinks by the nucleotide excision repair and the error-prone repair pathways.: J Mol Biol. 1999 Mar 12;286(5):1379-87. Unique Identifier : AIDSLINE MED/99165774; Barre FX; Asseline U; Harel-Bellan A; Institut de Recherche sur le Cancer, CNRS UPR 9079, 7 rue Guy; Moquet, Villejuif, 94801, France.; Psoralen is an asymmetric photoreactive intercalator with a furane and a pyrone side. When intercalated at 5 -TpA-3 sites and upon UVA irradiation, the psoralen can react with the thymine residues on both strands, introducing an interstrand crosslink. Using psoralen-coupled triple-helix-forming oligonucleotides, psor
HIV testing after implementation of name-based reporting [letter; comment]: JAMA. 1999 Apr 21;281(15):1377-8; discussion 1379-80. Unique Identifier : AIDSLINE MED/99231401; Aragon R; Myers J
HIV testing after implementation of name-based reporting [letter; comment]: JAMA. 1999 Apr 21;281(15):1378; discussion 1379-80. Unique Identifier : AIDSLINE MED/99231402; Woods WJ; Binson D; Morin S; Dilley JW
HIV testing after implementation of name-based reporting [letter; comment]: JAMA. 1999 Apr 21;281(15):1378-9; discussion 1379-80. Unique Identifier : AIDSLINE MED/99231403; Solomon L; Benjamin G; Wasserman M
HIV testing after implementation of name-based reporting [letter]: JAMA. 1999 Apr 21;281(15):1379-80. Unique Identifier : AIDSLINE MED/99231404; Paul SM; Cross H; Costa S
Extracellular water: sodium bromide dilution estimates compared with other markers in patients with acquired immunodeficiency syndrome.: JPEN J Parenter Enteral Nutr. 1999 Mar-Apr;23(2):61-6. Unique Identifier : AIDSLINE MED/99180031; Kim J; Wang Z; Gallagher D; Kotler DP; Ma K; Heymsfield SB; Obesity Research Center and Body Composition Unit, St; Luke's/Roosevelt Hospital, College of Physicians and Surgeons,; Columbia University, New York, New York, USA.; Extracellular fluid and closely related extracellular water (ECW) provide information on nutritional status in health and disease. Although various methods exist for ECW determination, little is known about their comparability in patients with wasting diseases such as acquired immunodeficiency syndrome (AIDS). One pra
[The molecular mechanisms governing T cell development in the thymus]: Nippon Rinsho. 1999 Feb;57(2):267-72. Unique Identifier : AIDSLINE MED/99177715; Kimura M; Nakayama T; Department of Molecular Immunology, Graduate School of Medicine,; Chiba University.; Intracellular signaling events required for T cell development in the thymus have been investigated using various gene deficient and transgenic mice. Here, we summarize and discuss the recent results. Immature thymocytes immigrated from bone marrow are found to be committed to lymphoid lineage. First, the lymphoid pro
[Retroviruses and autoimmune diseases]: Nippon Rinsho. 1999 Feb;57(2):310-5. Unique Identifier : AIDSLINE MED/99177722; Fugo K; Yoshiki T; 1st Department of Pathology, Hokkaido University School of; Medicine.; Various genetic factors and environmental factors are intricately intertwined in the pathomechanism of autoimmune diseases. Retroviruses, represented by HTLV-I and HIV, are known to relate to autoimmune disorders. However, the pathogenetic role of retrovirus and the relationship between retrovirus and autoimmune disea
[Practice and research of forensic medicine learned from the dead]: Nippon Hoigaku Zasshi. 1998 Oct;52(5):277-85. Unique Identifier : AIDSLINE MED/99177698; Tsunenari S; Department of Forensic Medicine, Kumamoto University School of; Medicine, Japan.; Practice and Research of Forensic Medicine Learned from the Dead is presented by looking back my 29 years carrier as a forensic pathologist. After joining in Department of Forensic Medicine, Kumamoto University in 1969, I had spent several happy years with studying on postmortem corneal clouding. Soon I began to hav
[Current status and perspectives on the development of rifamycin derivative antibiotics]: Kekkaku. 1999 Jan;74(1):53-61. Unique Identifier : AIDSLINE MED/99166028; Hidaka T; Takasago Research Laboratories, Kaneka Corporation, Hyogo, Japan.; Rifampicin (RFP) was developed as one of the anti-tuberculosis drugs in 1966 and has been used for almost 30 years. Establishment of combination therapy using RFP has been contributing to the treatment/eradication of tuberculosis. A number of rifamycin derivatives, as
Insurance and inpatient utilization for HIV: better answers, still further questions [editorial]: Med Care. 1999 Apr;37(4):325-8. Unique Identifier : AIDSLINE MED/99228000; Wu AW
Urethral Trichomonas vaginalis infection and HIV-1 transmission [letter]: Lancet. 1997 Oct 11;350(9084):1076. Unique Identifier : AIDSLINE MED/99228569; Jackson DJ; Rakwar JP; Bwayo JJ; Kreiss JK; Moses S
AIDS doctors push for live-virus vaccine trials [news]: Lancet. 1997 Oct 11;350(9084):1082. Unique Identifier : AIDSLINE MED/99228575; McCarthy M
HIV screening launched in Ireland [news]: Lancet. 1997 Oct 11;350(9084):1084. Unique Identifier : AIDSLINE MED/99228577; Birchard K
Tackling mother-to-child HIV in Cote d'Ivoire [news]: Lancet. 1997 Oct 11;350(9084):1084. Unique Identifier : AIDSLINE MED/99228578; Feinmann J
Brazilian haematologist sacked for speaking out over quality control [news]: Lancet. 1997 Oct 11;350(9084):1085. Unique Identifier : AIDSLINE MED/99228579; Csillag C
Should assays drive science or vice versa? [letter; comment]: Lancet. 1997 Oct 11;350(9084):1108. Unique Identifier : AIDSLINE MED/99228602; Johnston MI; Goudsmit J
Elective caesarean section for prevention of vertical transmission of HIV-1 infection [comment]: Lancet. 1999 Mar 27;353(9158):1030-1. Unique Identifier : AIDSLINE MED/99213437; Hudson CN; Department of Gynaecology, St Bartholomew's Hospital, London, UK.
A pill a day, or two, for hepatitis B?: Lancet. 1999 Mar 27;353(9158):1032-3. Unique Identifier : AIDSLINE MED/99213439; Dusheiko G; Department of Medicine, Royal Free and University College School; of Medicine, London, UK.
Elective caesarean-section versus vaginal delivery in prevention of vertical HIV-1 transmission: a randomised clinical trial. The European Mode of Delivery Collaboration [see comments]: Lancet. 1999 Mar 27;353(9158):1035-9. Unique Identifier : AIDSLINE MED/99213441; BACKGROUND: Results from observational studies suggest that caesarean-section delivery may reduce the risk of mother-to-child transmission of HIV-1 infection in comparison with vaginal delivery. We carried out a randomised clinical trial to address this issue and to assess the extent of postdelivery complications. MET
Site-directed polyethylene glycol modification of trichosanthin: effects on its biological activities, pharmacokinetics, and antigenicity.: Life Sci. 1999;64(14):1163-75. Unique Identifier : AIDSLINE MED/99224984; He XH; Shaw PC; Xu LH; Tam SC; Department of Physiology, The Chinese University of Hong Kong,; Shatin, NT.; Trichosanthin (TCS), a type I ribosome-inactivating protein (RIP), was modified with polyethylene glycol (PEG) in order to reduce its antigenicity and prolong its half-life. Computer modeling identified three potential antigenic sites namely Q219, K173 and S7. By site-directed mutagenesis, these sites were changed int
Effects of vesnarinone on cytokine production and activation of murine microglia.: Life Sci. 1999;64(14):1197-203. Unique Identifier : AIDSLINE MED/99224987; Suzumura A; Sawada M; Department of Neurology, Nara Medical University, Kashihara,; Japan.; Tumor necrosis factor alpha (TNF alpha) is considered to play a critical role in the development of various pathological processes in the central nervous system (CNS), such as neuronal degeneration, demyelination and gliosis. In order to search for agents which suppress TNF alpha production in the CNS for future treat
[HIV infection. Virus resistance: development and prevention]: Med Monatsschr Pharm. 1999 Mar;22(3):86-8. Unique Identifier : AIDSLINE MED/99232814; Link R; Miller V; Fatkenheuer G; Manegold C; Harrer T
HIV Tat represses transcription of the beta 2-microglobulin promoter.: Mol Immunol. 1998 Dec;35(18):1171-8. Unique Identifier : AIDSLINE MED/99213483; Carroll IR; Wang J; Howcroft TK; Singer DS; Molecular Regulation Section, Experimental Immunology Branch,; National Cancer Institute, NIH, Bethesda, MD 20892, USA.; The MHC class I complex, which binds and presents peptide antigen, is composed of a class I heavy chain and the beta2-microglobulin light chain. HIV-1, which induces a profound immunodeficiency in infected individuals, encodes proteins that cause decreased expression of class I heavy chain. We now report that the HIV
Discontinuation of primary prophylaxis against Pneumocystis carinii pneumonia in HIV-1-infected adults treated with combination antiretroviral therapy. Swiss HIV Cohort Study [see comments]: N Engl J Med. 1999 Apr 29;340(17):1301-6. Unique Identifier : AIDSLINE MED/99219763; Furrer H; Egger M; Opravil M; Bernasconi E; Hirschel B; Battegay M; Telenti A; Vernazza PL; Rickenbach M; Flepp M; Malinverni R; HIV-Sprechstunde, Inselspital Bern, Switzerland.; BACKGROUND: It is unclear whether primary prophylaxis against Pneumocystis carinii pneumonia can be discontinued in patients infected with the human immunodeficiency virus (HIV) who are successfully treated with combination antiretroviral therapy. We prospectively studied the safety of stopping prophylaxis among patie
Images in clinical medicine. Indinavir crystalluria.: N Engl J Med. 1999 Apr 29;340(17):1329. Unique Identifier : AIDSLINE MED/99219767; Tsao JW; Kogan SC; University of California, San Francisco 94143, USA.
Does Pneumocystis carinii prophylaxis still need to be lifelong? [editorial; comment]: N Engl J Med. 1999 Apr 29;340(17):1356-8. Unique Identifier : AIDSLINE MED/99219771; Masur H; Kaplan J
Cryptococcus meningoencephalitis in AIDS: parenchymal and meningeal forms.: Neuroradiology. 1999 Feb;41(2):129-33. Unique Identifier : AIDSLINE MED/99189015; Berkefeld J; Enzensberger W; Lanfermann H; Institut fur Neuroradiologie, Klinikum der; Johann-Wolfgang-Goethe Universitat, Frankfurt am Main, Germany.; Berkefeld@em.uni-frankfurt.de; CT and MRI in one case of Cryptococcus neoformans infection showed contrast-enhancing parenchymal lesions resembling granulomata or abscesses. After an initial phase without contrast enhancement, the full extent of the lesions was visible within 2 weeks of presentation. The enhancing masses were assumed to represent i
Gaining ground in progressive multifocal leukoencephalopathy [editorial; comment]: Neurology. 1999 Feb;52(3):440-1. Unique Identifier : AIDSLINE MED/99148635; Dolin R
Plasma viral load and CD4 lymphocytes predict HIV-associated dementia and sensory neuropathy.: Neurology. 1999 Feb;52(3):607-13. Unique Identifier : AIDSLINE MED/99148663; Childs EA; Lyles RH; Selnes OA; Chen B; Miller EN; Cohen BA; Becker JT; Mellors J; McArthur JC; School of Hygiene and Public Health, The Johns Hopkins; University, Baltimore, MD, USA.; OBJECTIVE: To determine the predictive value of plasma HIV RNA and CD4 lymphocytes for HIV-associated dementia and sensory neuropathy. METHODS: A total of 1,604 AIDS-free HIV seropositive men from the Multicenter AIDS Cohort Study were followed over a 10-year period (1985 to 1995).
HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathy [see comments]: Neurology. 1999 Feb;52(3):623-5. Unique Identifier : AIDSLINE MED/99148666; Clifford DB; Yiannoutsos C; Glicksman M; Simpson DM; Singer EJ; Piliero PJ; Marra CM; Francis GS; McArthur JC; Tyler KL; Tselis AC; Hyslop NE; Department of Neurology, Washington University School of; Medicine, St. Louis, MO, USA. cliffordd@neuro.wustl.edu; Introduction of highly active antiretroviral therapy (HAART) has been associated with many changes in the complications of human immunodeficiency virus (HIV) infection. A cohort of 25 HIV patients with progressive multifocal leukoencephalopathy (PML) treated with HAART experienced a median survival of >46 weeks. This
Role of T cells in murine IgA nephropathy.: Nephrol Dial Transplant. 1999;14 Suppl 1:12-3. Unique Identifier : AIDSLINE MED/99156183; Nagasawa R; Maruyama N; Imasawa T; Mitarai T; Division of Haemodialysis, Saitama Medical Centre, Saitama; Medical School, Japan.
Methycillin-resistant Staphylococcus aureus-related glomerulonephritis.: Nephrol Dial Transplant. 1999;14 Suppl 1:17-8. Unique Identifier : AIDSLINE MED/99156185; Kobayashi M; Koyama A; Department of Nephrology, Tokyo Medical University Kasumigaura; Hospital, Ibaraki, Japan.
Cytokine network and resident renal cells in glomerular diseases.: Nephrol Dial Transplant. 1999;14 Suppl 1:22-6. Unique Identifier : AIDSLINE MED/99156187; Schena FP; Institute of Nephrology, University of Bari, Polyclinic, Italy.; This review has highlighted the cytokine network which is involved in renal damage from an initial, even transient, stage to extensive glomerular and tubulointerstitial sclerosis. Studies of a variety of different proliferative glomerulonephritides have documented the prominent role of macrophages in infiltrating mesa
Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.: Pflugers Arch. 1999 Mar;437(4):538-46. Unique Identifier : AIDSLINE MED/99190753; Barcova M; Speth C; Kacani L; Uberall F; Stoiber H; Dierich MP; Institute for Hygiene, University of Innsbruck, Fritz-Pregl-Str.; 3, A-6020 Innsbruck, Austria.; Our previous results show that recombinant gp41 (aa565-647), the extracellular domain of HIV-1 transmembrane glycoprotein, stimulates interleukin-10 (IL-10) production in human monocytes. The signal cascade transducing this effect is not yet clear. In this study, we examined whether gp41-induced IL-10 up-regulation is
Localised upper airway obstruction in a patient with acquired immunodeficiency syndrome.: Postgrad Med J. 1998 Oct;74(876):604-6. Unique Identifier : AIDSLINE MED/99227801; D'Arsigny CL; Ford S; O'Donnell DE; Department of Medicine, Queen's University, Ontario, Canada.; We describe a case of rapidly progressive upper airway obstruction due to tracheal Pseudomonas abscesses in a patient with acquired immunodeficiency syndrome. The case highlights the aggressive nature of Pseudomonas infections and the difficulty of eradicating this organism in patients infected with the human immunode
[Bacteremia in tuberculosis and other mycobacterial infections]: Probl Tuberk. 1999;(1):54-9. Unique Identifier : AIDSLINE MED/99215401; Puzanov VA; Kosareva MV
Molecular dynamics study of the proposed beta-hairpin form of the switch domain from HIV1 gp120 alone and complexed with an inhibitor of CD4 binding.: Proteins. 1999 Feb 1;34(2):197-205. Unique Identifier : AIDSLINE MED/99144953; Graf von Stosch A; von der Lieth CW; Reed J; Department of Pathochemistry, German Cancer Research Center,; Heidelberg, Germany.; The strong tendency of beta-hairpin peptides to aggregate can prevent their structural resolution. The polar form of the switch peptide (LAV 15mer) at the CD4-binding domain of HIV1 gp120 is such a peptide, and NMR investigations of its interaction with a class of CD4-binding inhibitors developed in this laboratory ha
Analysis of domain motions in large proteins.: Proteins. 1999 Feb 15;34(3):369-82. Unique Identifier : AIDSLINE MED/99146628; Hinsen K; Thomas A; Field MJ; Laboratoire de Dynamique Moleculaire, Institut de Biologie; Structurale--Jean-Piere Ebel, Grenoble, France.; hinsen@cnrs-orleans.fr; We present a new approach for determining dynamical domains in large proteins, either based on a comparison of different experimental structures, or on a simplified normal mode calculation for a single conformation. In a first step, a deformation measure is evaluated for all residues in the protein; a high deformation
Estimating the proportion of treatment effect explained by a surrogate marker [letter]: Stat Med. 1999 Jan 15;18(1):107-9. Unique Identifier : AIDSLINE MED/99144507; Flandre P; Saidi Y
Classifying individuals based on predictors of random effects. Multicenter AIDS Cohort Study.: Stat Med. 1999 Jan 15;18(1):35-52. Unique Identifier : AIDSLINE MED/99144502; Lyles RH; Xu J; Department of Epidemiology, Johns Hopkins School of Hygiene and; Public Health, Baltimore, MD 21205, USA. rlyles@jhsph.edu; Often one wishes to describe individuals according to whether their average exposure over a period of time is above or below some meaningful threshold. In this article, we treat predictors of random effects as diagnostic tools to aid in such classification, given that the true unobservable mean exposure for each of a
A Markov model for measuring vaccine efficacy for both susceptibility to infection and reduction in infectiousness for prophylactic HIV vaccines.: Stat Med. 1999 Jan 15;18(1):53-68. Unique Identifier : AIDSLINE MED/99144503; Longini IM Jr; Hudgens MG; Halloran ME; Sagatelian K; Department of Biostatistics, Rollins School of Public Health,; Emory University, Atlanta, GA 30322, USA.; We use a discrete-time non-homogeneous Markov chain to model data from augmented human immunodeficiency virus (HIV) vaccine trials. For this design, the study population consists of primary participants some of whom have steady sexual partners who are also enrolled to augment the trial. The state space consists of the
[Reiter's syndrome and human immunodeficiency virus infection]: Rev Hosp Clin Fac Med Sao Paulo. 1998 Jul-Aug;53(4):202-4. Unique Identifier : AIDSLINE MED/99121257; de Mello e Silva AC; Boulos M; Faculdade de Medicina da Universidade de Sao Paulo.; The increase of rheumatic disorders in HIV infected has been known for the last decade with special emphasis on Reiter s Syndrome. In spite of common sources of HIV and other microorganisms being important in the pathogenesis of Reiter s Syndrome, severe immunodeficiency may be important in the development of rheumati
Comparison of 3 quantitative HCV RNA assays--accuracy of baseline viral load to predict treatment outcome in chronic hepatitis C.: Scand J Infect Dis. 1998;30(5):441-6. Unique Identifier : AIDSLINE MED/99163923; Reichard O; Norkrans G; Fryden A; Braconier JH; Sonnerborg A; Weiland O; Department of Infectious Diseases, Danderyd University Hospital,; Karolinska Institutet, Stockholm, Sweden.; The correlation between 3 assays for hepatitis C virus (HCV) RNA quantification and their respective accuracy in predicting the response to interferon and interferon/ribavirin therapy was evaluated by analysing pre-treatment sera from 100 patients. A total of 97%, 100%, and 98% of the patients tested positive by the b
Hepatitis C virus-infected, HCV-RNA-negative patients with bleeding disorders--relationship to age, HIV and treatment.: Scand J Infect Dis. 1998;30(5):455-8. Unique Identifier : AIDSLINE MED/99163926; Schulman S; Von Sydow M; Petrini P; Fahlstadius P; Department of Medicine, Karolinska Hospital, Stockholm, Sweden.; All 155 anti-hepatitis C-virus (HCV) positive patients with haemostatic disorders at our unit were tested for HCV-RNA in order to determine the prevalence of a negative result. The patients were also characterized in order to find predictors for a negative HCV-RNA test. The prevalence of a negative HCV-RNA test was 15
Changes in small intestinal structure and function in HIV-infected patients with chronic diarrhoea.: Scand J Infect Dis. 1998;30(5):459-63. Unique Identifier : AIDSLINE MED/99163927; Oktedalen O; Skar V; Dahl E; Serck-Hanssen A; Department of Medicine and Pathology, Ullevaal University; Hospital, Oslo, Norway.; Human immunodeficiency virus (HIV) is often combined with unexplainable diarrhoea and weight loss. This study was designed to see if changes in the intestinal mucosal structure could explain the malabsorption found in HIV-infected patients with diarrhoea. Twenty acquired immunodeficiency system (AIDS) patients, 19 men
Low levels of IgG antibodies against pneumocystis carinii among HIV-infected patients.: Scand J Infect Dis. 1998;30(5):495-9. Unique Identifier : AIDSLINE MED/99163935; Laursen AL; Andersen PL; Department of Infectious Diseases, Marselisborg Hospital,; University of Aarhus, Denmark.; IgG antibodies against Pneumocystis carinii (P. carinii) were detected by an ELISA method using urea-extracted material from human and rat P. carinii as the antigen. Carbohydrate formed a major part of the antigen responsible for reactivity in the ELISA assay, since periodate treatment reduced the reactivity of most s
Arthritis due to mycobacterium fortuitum.: Scand J Infect Dis. 1998;30(5):525-7. Unique Identifier : AIDSLINE MED/99163943; Butt AA; Janney A; Department of Medicine, Louisiana State University Medical; Center, New Orleans, USA.; Mycobacterium fortuitum is classified as a rapidly growing mycobacterium (RGM) according to the Runyon classification. RGM are increasingly being recognized as human pathogens. Joint infection due to M. fortuitum is a rare, but serious disease. This report describes a patient with acquired immunodeficiency syndrome (A
A rare case of cotrimoxazole-induced eosinophilic aseptic meningitis in an HIV-infected patient.: Scand J Infect Dis. 1998;30(5):530-1. Unique Identifier : AIDSLINE MED/99163945; Patey O; Lacheheb A; Dellion S; Zanditenas D; Jungfer-Bouvier F; Lafaix C; Service de Medecine Interne, Maladies Infectieuses et; Tropicales, Villeneuve St Georges, France.; A case of cotrimoxazole-induced meningoencephalitis in an HIV-infected patient without signs of AIDS is reported. The patient developed an apparently generalized seizure, of cotrimoxazole, 1 month after first taking a dose of this drug and a febrile coma after a second dose 3 weeks later. Lumbar puncture revealed eosi
In the company of friends: peer influence on Thai male extramarital sex.: Soc Sci Med. 1998 Dec;47(12):1993-2011. Unique Identifier : AIDSLINE MED/99173564; Vanlandingham M; Knodel J; Saengtienchai C; Pramualratana A; Department of Preventive Medicine and Community Health,; University of Texas Medical Branch, Galveston 77555-1153, USA.; mvanland@utmb.edu; We explore some of the key social dynamics underlying patterns of male extramarital heterosexual behavior in Thailand . We analyze transcripts of focus group discussions and focused individual interviews conducted during 1993 and 1994 with married men and women living in both urba
The social impact of HIV testing: a comparative analysis of Britain and Sweden.: Soc Sci Med. 1999 Feb;48(3):293-300. Unique Identifier : AIDSLINE MED/99174895; Danziger R; Department of Public Health and Policy, London School of Hygiene; and Tropical Medicine, UK. r.danziger@lshtm.ac.uk; The role of HIV testing in the primary prevention of HIV is as yet unclear. Whereas most outcome evaluations have tended to focus on the impact of HIV testing and counselling on individuals risk behaviours, this paper argues for a fresh perspective on HIV testing which takes into account its social impact. To illustr
Pre-test counselling for HIV--short and friendly please [letter]: S Afr Med J. 1999 Jan;89(1):11-2. Unique Identifier : AIDSLINE MED/99169547; Mankazana M
The costing of HIV/AIDS--without a clue?: S Afr Med J. 1999 Jan;89(1):33-4. Unique Identifier : AIDSLINE MED/99169557; van der Linde I
Cheaper to manage HIV than to treat AIDS--the Medscheme experience.: S Afr Med J. 1999 Jan;89(1):34-5. Unique Identifier : AIDSLINE MED/99169558; Cowlin J
[Central nervous system lymphoma]: Sangre (Barc). 1998 Dec;43(6):527-33. Unique Identifier : AIDSLINE MED/99189684; Cristobal CB; Universidad Complutense de Madrid.
Community education for stroke awareness: An efficacy study.: Stroke. 1999 Apr;30(4):720-3. Unique Identifier : AIDSLINE MED/99205321; Stern EB; Berman M; Thomas JJ; Klassen AC; Program in Occupational Therapy, Department of Physical Medicine; and Rehabilitation, University of Minnesota, Minneapolis, Minn.; 55455, USA.Stern001@tc.umn.edu; BACKGROUND AND PURPOSE: This study examined the effectiveness of a slide/audio community education program aimed at increasing knowledge of stroke risk factors, stroke warning signs, and action needed when stroke warning signs occur. The program targets audiences at higher risk for stroke, especially individuals who a
Cerebral vasculopathy in HIV infection revealed by transcranial Doppler: A pilot study.: Unique Identifier : AIDSLINE MED/99205337; Brilla R; Nabavi DG; Schulte-Altedorneburg G; Kemeny V; Reichelt D; Evers S; Schiemann U; Husstedt IW; BACKGROUND AND PURPOSE: There is growing evidence for affection of cerebral vessels during human immunodeficiency virus (HIV) infection. We prospectively evaluated cerebrovascular reserve capacity (CRC) in HIV-seropositive patients by transcranial Doppler sonography (TCD) after systemic administration of acetazolamide
Co-trimoxazole and stavudine interference in a high-performance liquid chromatographic analysis for didanosine in human plasma.: Ther Drug Monit. 1998 Dec;20(6):669-72. Unique Identifier : AIDSLINE MED/99068874; Hoetelmans RM; Profijt M; Meenhorst PL; Mulder JW; van Heeswijk RP; Beijnen JH; Department of Pharmacy and Pharmacology, Slotervaart Hospital,; Amsterdam, The Netherlands.; Recently, the authors were confronted with interference of stavudine and co-trimoxazole when analyzing the antiretroviral drug didanosine (ddI) in plasma of HIV-1-infected patients using reverse-phase high-performance liquid chromatography with ultrav
Sodium stibogluconate (pentostan) overdose in a patient with acquired immunodeficiency syndrome.: Ther Drug Monit. 1998 Dec;20(6):714-6. Unique Identifier : AIDSLINE MED/99068882; Reymond JM; Desmeules J; Medical Clinic 1, Department of Internal Medicine, Geneva; University Hospital, Switzerland.; A 32-year-old man with acquired immunodeficiency syndrome (AIDS) admitted to the hospital for treatment of visceral leishmaniasis was inadvertently given 10 times the prescribed first dose of sodium stibogluconate ([Sb] 6.5 g instead of 0.65 g). He experienced no immediate major toxicity during the first 48 hours, but
[Carriers of Staphylococcus aureus as a source of nosocomial infections. Epidemiological and prophylactic aspects]: Ugeskr Laeger. 1999 Mar 15;161(11):1580-4. Unique Identifier : AIDSLINE MED/99218718; Kolmos HJ; Klinisk mikrobiologisk afdeling, H:S Hvidovre Hospital.; 20% of the normal population are nasal carriers of Staphylococcus aureus (Sa), and the carrier rate is even higher in insulin dependent diabetics, intravenous drug addicts, patients on haemo- and peritoneal dialysis, and HIV infected patients. Nasal Sa carriers have an increased risk of Sa infections following invasiv
[Antiretroviral treatment (editorial)]: Ugeskr Laeger. 1999 Mar 22;161(12):1731. Unique Identifier : AIDSLINE MED/99227414; Nielsen HI
[Anesthesiologic aspects in patients with HIV infections]: Ugeskr Laeger. 1999 Mar 22;161(12):1744-6. Unique Identifier : AIDSLINE MED/99227418; Laursen SB; Nielsen TL; Jacobsen E; H:S Rigshospitalet,epidemiafdeling M.; A review of anaesthesia for patients with HIV-infection is given. The use of new antiretroviral drug combinations to treat HIV-infection may result in longer survival, and therefore more cases of HIV-positive patients who undergo surgery and require anaesthetic services. Clinical manifestations of the HIV infection in
[Experiences with antiretroviral combination therapy]: Ugeskr Laeger. 1999 Mar 22;161(12):1747-51. Unique Identifier : AIDSLINE MED/99227419; Justesen US; Mygind LH; Pedersen SS; Pedersen C; Odense Universitetshospital, medicinsk afdeling C.; The purpose of the study was to evaluate the efficacy of treating of HIV infected patients with two nucleoside analogues and one protease inhibitor in clinical practice. Sixty-one patients were included and followed with respect to plasma HIV-RNA, CD4 cell count and side effects up to one year. Median plasma HIV-RNA w
[Treatment of HIV infections and AIDS with protease inhibitor and two nucleoside analogs]: Ugeskr Laeger. 1999 Mar 22;161(12):1751-4. Unique Identifier : AIDSLINE MED/99227420; Jensen-Fangel S; Larsen L; Thomsen HF; Nielsen LP; Black FT; Obel N; Arhus Universitetshospital, Marselisborg Hospital, medicinsk; epidemisk afdeling A.; Until December 31st 1997, 163 HIV/AIDS patients were treated with HAART at the Department of Infectious Diseases, Aarhus University Hospital. The patients mainly received a combination of zidovudine, lamivudine and saquinavir. They were observed for an average period of 375 days. HAART was found to increase the amount
[Cell tropism of HIV]: Uirusu. 1998 Dec;48(2):153-61. Unique Identifier : AIDSLINE MED/99177772; Koyanagi Y; Department of Microbiology and Molecular Virology, Tokyo Medical; and Dental University, Japan.
[Rudolf-Virchow Prize 1998. Award lecture. Toxoplasmosis: a model infection for studying systemic and intracerebral immune reactions]: Unique Identifier : AIDSLINE MED/99195117; Deckert-Schluter M; Toxoplasmosis has gained particular attention in the AIDS era as the most common opportunistic encephalitis in HIV-infected patients. Since there are important parallels between the human and rodent infection, experimental murine toxoplasmosis is widely used to study the immune reactions to this protozoal parasite. Or
AAP policy on children with HIV-infected parents. American Academy of Pediatrics [news]: Am Fam Physician. 1999 Apr 1;59(7):2022-3. Unique Identifier : AIDSLINE MED/99223414; Rose VL
An ethnographic comparison of HIV risk behaviors among heroin and methamphetamine injectors.: Am J Drug Alcohol Abuse. 1999 Feb;25(1):1-23. Unique Identifier : AIDSLINE MED/99176861; Zule WA; Desmond DP; Department of Psychiatry, The University of Texas Health Science; Center at San Antonio, USA.; Drug injection and other practices affecting the risk of human immunodeficiency virus (HIV) infection were studied among 154 heroin users and 45 methamphetamine users in San Antonio, Texas. Amphetamine users were younger, mostly white, and had less-severe drug dependence. Heroin users had significantly higher levels o
Depressive symptoms, drug network, and their synergistic effect on needle-sharing behavior among street injection drug users.: Am J Drug Alcohol Abuse. 1999 Feb;25(1):117-27. Unique Identifier : AIDSLINE MED/99176867; Mandell W; Kim J; Latkin C; Suh T; Department of Mental Hygiene, Johns Hopkins University School of; Hygiene and Public Health, Baltimore, Maryland, USA.; In this study, we examined the relationship between depressive symptoms and needle-sharing behavior in a community sample of intravenous drug users (N = 499) in Baltimore, Maryland. Based on the polytomous logistic regression, higher depressive symptoms were positively associated both with needle sharing after cleanin
Women inmates' risky sex and drug behaviors: are they related?: Am J Drug Alcohol Abuse. 1999 Feb;25(1):129-49. Unique Identifier : AIDSLINE MED/99176868; Cotten-Oldenburg NU; Jordan BK; Martin SL; Kupper L; AIDS/STD Prevention Services Section, Minnesota Department of; Health, Minneapolis 55440-9441, USA.; The large concentration of female illicit drug users in state correctional facilities prompted an examination of the associations among different types of drug use and sexual risk factors related to human immunodeficiency virus (HIV) among women inmates. A consecutive sample of 805 women felons admitted to the North C
Absence of age-related increase in systolic blood pressure in ambulatory patients with HIV infection.: Am J Med Sci. 1999 Apr;317(4):232-7. Unique Identifier : AIDSLINE MED/99225083; Mattana J; Siegal FP; Sankaran RT; Singhal PC; Department of Medicine, Long Island Jewish Medical Center, New; Hyde Park, New York 11040, USA.; BACKGROUND: Systolic blood pressure is well known to increase significantly with age and is strongly correlated with stroke and coronary artery disease. We and other investigators have reported a low prevalence of hypertension in subgroups of patients with HIV infection. In the present study, we examined an ambulatory
Hygienic practices of consultant anaesthetists: a survey in the north-west region of the UK.: Anaesthesia. 1999 Jan;54(1):13-8. Unique Identifier : AIDSLINE MED/99225839; el Mikatti N; Dillon P; Healy TE; Anaesthetic Department of TU 3, South Manchester University; Hospital NHS Trust, Withington Hospital, UK.; Questionnaires were distributed to all 213 consultant anaesthetists in the North-West region of the UK with a response rate of 68%. These questionnaires were designed to assess the hygienic precautions taken to reduce the potential for transmission of infectious agents to and from the patients under their care. Face m
Glove usage and reporting of needlestick injuries by junior hospital medical staff.: Ann R Coll Surg Engl. 1998 Nov;80(6):439-41. Unique Identifier : AIDSLINE MED/99225892; Hettiaratchy S; Hassall O; Watson C; Wallis D; Williams D; Accident and Emergency Department, St Thomas' Hospital, London.; The use of gloves when conducting invasive procedures and the reporting of needlestick injuries have been strongly encouraged. Despite this, neither practice appears to be universal. In order to determine the rates of glove usage and needlestick injury reporting, we conducted a survey of junior doctors in three hospit
Cage dimeric 4-aryl-1,4-dihydropyridines as promising lead structures for the development of a novel class of HIV-1 protease inhibitors.: Arch Pharm (Weinheim). 1999 Jan;332(1):3-5. Unique Identifier : AIDSLINE MED/99172792; Hilgeroth A; Billich A; Institut fur Pharmazeutische Chemie der; Martin-Luther-Universitat Halle-Wittenberg, Germany.
Pre-AIDS physical disability [letter]: Arch Phys Med Rehabil. 1999 Apr;80(4):473. Unique Identifier : AIDSLINE MED/99221456; Brown A; Christie JD; Kotzker WR; Lautenbach E
Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters.: Biochem J. 1999 Feb 15;338 ( Pt 1):107-13. Unique Identifier : AIDSLINE MED/99131993; Basak A; Cooper S; Roberge AG; Banik UK; Chretien M; Seidah NG; Laboratories of Structure and Metabolism of Neuropeptides,; Clinical Research Institute, University of Montreal, Que,; Canada. Basaka@ircm.umontreal.ca; Studies were performed to investigate the prohormone/proprotein convertase (PC)-inhibitory properties of chemical constituents of the medicinally active plant Andrographis paniculata (AP; from the family Acanthaceae), also known as King of Bitters . Among the individual components tested against the clinically import
Purification, characterization and molecular cloning of trichoanguin, a novel type I ribosome-inactivating protein from the seeds of Trichosanthes anguina.: Biochem J. 1999 Feb 15;338 ( Pt 1):211-9. Unique Identifier : AIDSLINE GENBANK/AF055086; Chow LP; Chou MH; Ho CY; Chuang CC; Pan FM; Wu SH; Lin JY; Institute of Biochemistry, College of Medicine, National Taiwan; University, Taipei, Republic of China. lupin@ha.mc.ntu.edu.tw; The seeds of the plant Trichosanthes anguina contain a type I ribosome-inactivating protein (RIP), designated trichoanguin, which was purified to apparent homogeneity by the combined use of ion-exchange chromatographies, i.e. first with DE-52 cellulose and then with CM-52 cellulose. The protein was found to be a glyco
A study of sex differences in presentation for care of HIV.: Aids Patient Care STDS. 1999 Feb;13(2):103-10. Unique Identifier : AIDSLINE AIDS/99168137; Biber CL; Jaker MA; Kloser P; Auerbach SB; Rhoads GG; University of Medicine and Dentistry of New Jersey, New Jersey; Dental School, Newark, USA.; The current study examines sex differences in 183 male and 141 female patients presenting for care of HIV disease at an inner city hospital infectious disease clinic. Females (43%) were found to be less likely to have a history of illicit drug use (relative risk = .77, p
Disclosure, stress, and psychological adjustment among mothers affected by HIV.: Aids Patient Care STDS. 1999 Feb;13(2):111-8. Unique Identifier : AIDSLINE AIDS/99168138; Murphy LM; Koranyi K; Crim L; Whited S; Otterbein College, Westerville, Ohio, USA.; lbmurphy@ocalpha.otterbein.edu; This study examined patterns of disclosure and psychological adjustment among mothers infected or affected by HIV. All participants were followed through a family AIDS clinic at a midwestern children s hospital. With respect to disclosure, results indicated that high perceived stress (r = 0.50, p = 0.001) and low effi
Psychosocial issues of women with HIV/AIDS.: Aids Patient Care STDS. 1999 Feb;13(2):119-26. Unique Identifier : AIDSLINE AIDS/99168139; Broun SN; Department of Psychology, Southwestern Medical School, Dallas,; Texas, USA.; This article discusses some of the issues specifically associated with women and HIV. The myth is that women do not get AIDS and that lesbians do not get AIDS either. It also explores the unique sociocultural context in which HIV-infected women exist. The hope is to put faces on the numbers that are increasing each da
Chinese herbs treat protease-inhibitor diarrhea [news]: Aids Patient Care STDS. 1999 Feb;13(2):127. Unique Identifier : AIDSLINE AIDS/99168142
Premature heart disease with protease inhibitors [news]: Aids Patient Care STDS. 1999 Feb;13(2):127. Unique Identifier : AIDSLINE AIDS/99168140
Risky sex for patients on protease inhibitors [news]: Aids Patient Care STDS. 1999 Feb;13(2):127. Unique Identifier : AIDSLINE AIDS/99168141
Sustiva provides suppression of HIV in patients with high viral loads [news]: Aids Patient Care STDS. 1999 Feb;13(2):127-8. Unique Identifier : AIDSLINE AIDS/99168143
Viramune now available for use in HIV-positive children [news]: Aids Patient Care STDS. 1999 Feb;13(2):128. Unique Identifier : AIDSLINE AIDS/99168144
Agenerase shows promise in treatment-naive and treatment-experienced HIV patients [news]: Aids Patient Care STDS. 1999 Feb;13(2):128-9. Unique Identifier : AIDSLINE AIDS/99168145
Pan-European program provides HIV genotyping [news]: Aids Patient Care STDS. 1999 Feb;13(2):130. Unique Identifier : AIDSLINE AIDS/99168146
STD organism may have role in HIV [news]: Aids Patient Care STDS. 1999 Feb;13(2):131. Unique Identifier : AIDSLINE AIDS/99168147
Interferon successful in both prior non-responders and prior relapsers with hepatitis C [news]: Aids Patient Care STDS. 1999 Feb;13(2):132. Unique Identifier : AIDSLINE AIDS/99168148
New Candida yeast causes invasive infections [news]: Aids Patient Care STDS. 1999 Feb;13(2):132-3. Unique Identifier : AIDSLINE AIDS/99168149
Famvir effective in preventing genital herpes recurrences in people with HIV [news]: Aids Patient Care STDS. 1999 Feb;13(2):133. Unique Identifier : AIDSLINE AIDS/99168150
HIV and STD prevention update. CDC updates recommendations for hepatitis C. Part Two: prevention and control.: Aids Patient Care STDS. 1999 Feb;13(2):135-8. Unique Identifier : AIDSLINE AIDS/99168151; Makulowich GS
Changes at Clearinghouse [news]: Aids Patient Care STDS. 1999 Feb;13(2):75. Unique Identifier : AIDSLINE AIDS/99168124
Cities report decreases [news]: Aids Patient Care STDS. 1999 Feb;13(2):75. Unique Identifier : AIDSLINE AIDS/99168130
First pain center for HIV [news]: Aids Patient Care STDS. 1999 Feb;13(2):75. Unique Identifier : AIDSLINE AIDS/99168129
Housing in Connecticut [news]: Aids Patient Care STDS. 1999 Feb;13(2):75. Unique Identifier : AIDSLINE AIDS/99168125
Montagnier labs built [news]: Aids Patient Care STDS. 1999 Feb;13(2):75. Unique Identifier : AIDSLINE AIDS/99168127
Smoking and HIV [news]: Aids Patient Care STDS. 1999 Feb;13(2):75. Unique Identifier : AIDSLINE AIDS/99168128
Texas starts reporting [news]: Aids Patient Care STDS. 1999 Feb;13(2):75. Unique Identifier : AIDSLINE AIDS/99168126
Update conference set [news]: Aids Patient Care STDS. 1999 Feb;13(2):75. Unique Identifier : AIDSLINE AIDS/99168123
Home testing rates [news]: Aids Patient Care STDS. 1999 Feb;13(2):76. Unique Identifier : AIDSLINE AIDS/99168131
HPV vaccine [news]: Aids Patient Care STDS. 1999 Feb;13(2):76. Unique Identifier : AIDSLINE AIDS/99168132
Women and AIDS [editorial]: Aids Patient Care STDS. 1999 Feb;13(2):77-9. Unique Identifier : AIDSLINE AIDS/99168133; Laurence J
Persistent flank pain, low-grade fever, and malaise in a woman treated with indinavir.: Aids Patient Care STDS. 1999 Feb;13(2):81-7. Unique Identifier : AIDSLINE AIDS/99168134; Sarcletti M; Zangerle R; Department of Dermatology and Venereology, University of; Innsbruck, Austria.; This case report describes a 32-year-old woman treated with indinavir who developed mild to moderate flank pain, malaise, and low-grade fever. Sterile pyuria preceded increased serum creatinine levels. Workup revealed persistent pyuria, normal-sized k
Issues for women with heterosexually transmitted HIV disease.: Aids Patient Care STDS. 1999 Feb;13(2):89-96. Unique Identifier : AIDSLINE AIDS/99168135; Gaskins S; Capstone College of Nursing, University of Alabama, Tuscaloosa,; USA.; The encouraging outcome of new antiretroviral therapies has not been accompanied by a decrease in the incidence of HIV disease. There are reports of increases in AIDS in select geographical areas, minorities, and women. In 1997, 39% of cases in women were from heterosexual contact, whereas in men 7% of cases were from
Prenatal care and HIV infection.: Aids Patient Care STDS. 1999 Feb;13(2):97-102. Unique Identifier : AIDSLINE AIDS/99168136; Lancioni C; Harwell T; Rutstein RM; University of Pennsylvania School of Medicine, Philadelphia, USA.; Recent use of zidovudine (ZDV) to reduce vertical transmission of HIV disease in newborns has demonstrated varied, but in some studies, dramatic results, with reports of reduction from approximately 8% to 25%. With this potential of efficacy in saving lives, knowledge of access to prenatal care for HIV-infected pregna
Stroke and seizures as the presenting signs of pediatric HIV infection.: Pediatr Neurol. 1999 Jan;20(1):53-6. Unique Identifier : AIDSLINE MED/99151719; Visudtibhan A; Visudhiphan P; Chiemchanya S; Department of Pediatrics, Faculty of Medicine, Ramathibodi; Hospital, Mahidol University, Bangkok, Thailand.; The authors report two pediatric patients with definite human immunodeficiency virus infection whose initial presentation was stroke and seizure. The first patient was a 3-year-old female who developed acute hemiparesis as the first manifestation. The other, a 2-month-old infant, had focal seizures secondary to cerebr
Evaluation of monoclonal antibody reagents from three different manufacturers using flow cytometric two-color immunophenotyping.: Asian Pac J Allergy Immunol. 1998 Dec;16(4):185-92. Unique Identifier : AIDSLINE MED/99235306; Pattanapanyasat K; Thepthai C; Thepthai A; Lerdwana S; Darden JM; Center of Excellence for Flow Cytometry, Division of Instruments; for Research, Office for Research and Development, Faculty of; Medicine Siriraj Hospital, Bangkok, Thailand.; We evaluated a flow cytometric (FCM) two-color immunophenotyping of CD3+/CD4+ T-helper and CD3+/CD8+ T-suppressor lymphocytes in whole blood samples from HIV-infected individuals using monoclonal antibody reagents from three different manufacturers. Lymphocytes were firstly determined using CD45/CD14 in association wi
Microbe exposure, innate immunity and autoimmunity [letter]: Immunol Today. 1999 Jan;20(1):54. Unique Identifier : AIDSLINE MED/99181073; Ristori G; Buttinelli C; Pozzilli C; Fieschi C; Salvetti M
Phenolic aporphine-benzylisoquinoline alkaloids from Thalictrum faberi.: Phytochemistry. 1999 Mar;50(5):829-34. Unique Identifier : AIDSLINE MED/99209047; Lin LZ; Hu SF; Chu M; Chan TM; Chai H; Angerhofer CK; Pezzuto JM; Cordell GA; Department of Medicinal Chemistry and Pharmacognosy, College of; Pharmacy, University of Illinois at Chicago 60612-7231, USA.; From the roots of Thalictrum faberi, six new phenolic aporphine-benzylisoquinoline alkaloids, 3-hydroxy-6 -desmethyl-9-O-methylthalifaboramine (1), 3-hydroxythalifaboramine (2), 6 -desmethylthalifaboramine (3); 3,5 -dihydroxythalifaboramine (4), 5 -hydroxythalifaboramine (5) and 3-hydroxy-6 -desmethylthalifaboramine (
Single-administration vaccines: controlled-release technology to mimic repeated immunizations.: Trends Biotechnol. 1999 Jan;17(1):25-9. Unique Identifier : AIDSLINE MED/99198348; Cleland JL; Pharmaceutical R&D, Genentech, South San Francisco, CA 94080,; USA. cleland@gene.com; The most effective mechanism for the elimination of disease from society is the use of vaccinations, but these often require repeated administration. However, single-administration vaccine formulations provide the repeated administrations automatically. One approach is the development of injectable controlled-release
[The acceptability of experimentation on the efficacy of an anti-HIV vaccine among Italian drug addicts]: Ann Ig. 1999 Jan-Feb;11(1):27-34. Unique Identifier : AIDSLINE MED/99224448; Nicolosi A; Dipartimento di Epidemiologia e Informatica Medica, Istituto di; Tecnologie Biomediche Avanzate, Consiglio Nazionale delle; Ricerche, Segrate, MI.
HLA-A, -B, -C, -DRB1, DRB3, DRB4, DRB5 and DQB1 polymorphism detected by PCR-SSP in a semi-urban HIV-positive Ugandan population.: Exp Clin Immunogenet. 1999;16(1):17-25. Unique Identifier : AIDSLINE MED/99189129; Krausa P; McAdam S; Bunce M; Whitworth J; Biryahwaho B; French N; Tugume B; Gilks C; Gotch F; Molecular Immunology Group, Institute of Molecular Medicine,; Oxford, UK.; PCR-SSP was used to HLA-type a cohort of Ugandan HIV-positive individuals. The results represent a more comprehensive description of HLA in an African population than previously described and are in concordance with data from a general Black population. Substantial differences exist between this population and Caucaso
Predictors of failure to return for HIV test result and counseling by test site type.: AIDS Educ Prev. 1999 Feb;11(1):1-13. Unique Identifier : AIDSLINE MED/99169791; Molitor F; Bell RA; Truax SR; Ruiz JD; Sun RK; California Department of Health Services, Office of AIDS, USA.; The objective of this study was to determine the primary predictors of failure to return (FTR) for HIV test results and counseling by test site type from among those variables collected during the pretest, risk assessment session. The study sample consisted of 366,280 clients tested for HIV antibodies over an 18-month
Psychosocial correlates of voluntary HIV antibody testing in college students.: AIDS Educ Prev. 1999 Feb;11(1):14-27. Unique Identifier : AIDSLINE MED/99169792; Dorr N; Krueckeberg S; Strathman A; Wood MD; Department of Psychology, University of Missouri-Columbia 65211,; USA.; Although past research has examined correlates of HIV testing, much of it has focused on demographic differences between tested and nontested individuals. The present study examined psychosocial differences between individuals seeking a voluntary HIV test at a college student health center and individuals who have nev
Voluntary HIV testing in prison: do women inmates at high risk for HIV accept HIV testing?: AIDS Educ Prev. 1999 Feb;11(1):28-37. Unique Identifier : AIDSLINE MED/99169793; Cotten-Oldenburg NU; Jordan BK; Martin SL; Sadowski LS; AIDS/STD Prevention Services Section, Minnesota Health; Department, Minneapolis 55440-9441, USA.; This study examined the proportion of women inmates who accepted HIV testing and the sociodemographic, criminal, and HIV-related risk characteristics associated with accepting such testing in a state prison offering voluntary HIV testing. A consecutive sample of 805 women felons admitted to the North Carolina Correcti
Correlates of condom use stage of change: implications for intervention.: AIDS Educ Prev. 1999 Feb;11(1):38-52. Unique Identifier : AIDSLINE MED/99169794; Polacsek M; Celentano DD; O'Campo P; Santelli J; Department of Family and Community Medicine, University of New; Mexico, Albuquerque, USA.; A telephone survey was used to collect data on attitudes, beliefs, and practices concerning condom use among 812 African Americans with regular sex partners and of reproductive age in Baltimore. Condom use was staged according to Prochaska s model of stage of behavioral change. Characteristics of the respondents se
Hope and resilience in suicide ideation and behavior of gay and bisexual men following notification of HIV infection.: AIDS Educ Prev. 1999 Feb;11(1):53-64. Unique Identifier : AIDSLINE MED/99169795; Siegel K; Meyer IH; Columbia University, School of Public Health, Division of; Sociomedical Sciences, New York, NY 10032, USA.; Upon being notified that they are positive for HIV, people often experience terror and confusion. At the beginning stages of coping with HIV diagnosis, suicide ideation and behavior may arise as the infected person begins to envision frightening images of a future life with AIDS. We examined the narratives of gay men
Experiences of 100 men who have sex with men using the Reality condom for anal sex.: AIDS Educ Prev. 1999 Feb;11(1):65-71. Unique Identifier : AIDSLINE MED/99169796; Gibson S; McFarland W; Wohlfeiler D; Scheer K; Katz MH; HIV Seroepidemiology Unit, San Francisco Department of Public; Health, CA 94102-6033, USA.; A self-administered, anonymous questionnaire examining opinions and experiences of using Reality, the female condom, for anal sex was completed by a convenience sample of 100 men who have sex with men (MSM). Eighty-six percent of respondents said they would use Reality again; 54% would rather use Reality than penile
Factors influencing attitudes within AIDS service organizations toward the use of research-based HIV prevention interventions.: AIDS Educ Prev. 1999 Feb;11(1):72-86. Unique Identifier : AIDSLINE MED/99169797; DiFranceisco W; Kelly JA; Otto-Salaj L; McAuliffe TL; Somlai AM; Hackl K; Heckman TG; Holtgrave DR; Rompa DJ; Department of Psychiatry and Behavioral Medicine, Medical College; of Wisconsin, Milwaukee 53226-0509, USA. wayned@mcw.edu; Although the efficacy of small-group, risk reduction interventions based on cognitive behavioral principles has been widely documented in HIV behavioral research literature, little is known about how AIDS service organizations (ASOs) view these research-based models. From a nationwide sample of 77 ASOs, this study ass
Training community members to conduct survey interviews: notes from a study of seropositive women.: AIDS Educ Prev. 1999 Feb;11(1):87-8. Unique Identifier : AIDSLINE MED/99169798; Simoni JM; Weinberg BA; Nero DK; Ferkauf Graduate School of Psychology, Yeshiva University, Bronx,; New York, USA.
Epidemiology of Kaposi's sarcoma in Scotland, 1976-1996.: Br J Cancer. 1999 Apr;79(11-12):1938-42. Unique Identifier : AIDSLINE MED/99221159; Brewster DH; Harris V; Black RJ; Goldberg DJ; Information & Statistics Division, Trinity Park House, Edinburgh,; Scotland, UK.; Based on data from the Scottish Cancer Registry, the epidemiology of Kaposi s sarcoma (KS) in Scotland during the period 1976-96 is described. In males, the annual age-standardized incidence rate (World standard population) increased from less than 0.09 per 100,000 before 1986 to 0.44 in 1991 and then decreased to aro
The effect of template RNA structure on elongation by HIV-1 reverse transcriptase.: Biochim Biophys Acta. 1999 Mar 19;1444(3):355-70. Unique Identifier : AIDSLINE MED/99196709; Klasens BI; Huthoff HT; Das AT; Jeeninga RE; Berkhout B; Department of Human Retrovirology, Academic Medical Center,; University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The; Netherlands.; Reverse transcription of the RNA genome of retroviruses has to proceed through some highly structured regions of the template. The RNA genome of the human immunodeficiency virus type 1 (HIV-1) contains two hairpin structures within the repeat (R) region at the 5 end of the viral RNA (Fig. 1Fig. 1Template RNA structur
[Colon involvement as a form of presentation of visceral leishmaniasis in an AIDS patient (letter)]: Enferm Infecc Microbiol Clin. 1999 Feb;17(2):102-3. Unique Identifier : AIDSLINE MED/99209157; Marcas A; Pedrol E; Llargues E; Bernet M
[Invasive aspergillosis in patients with human immunodeficiency virus infection diagnosed by necropsy: the contribution of 4 cases and review of the literature]: Enferm Infecc Microbiol Clin. 1999 Feb;17(2):69-73. Unique Identifier : AIDSLINE MED/99209145; Gonzalez JJ; Pintor E; Hinojosa J; Barreiro PM; Roca V; Chao M; Colmenero I; Servicio de Medicina Interna III, Hospital Clinico Universitario; San Carlos, Madrid.; BACKGROUND: Invasive aspergillosis is an infrequent clinicopathological entity which is difficult to diagnose (since it requires tissue samples, normally of the lung where the pathogenic effect of the fungi may be seen) and thus an important number of cases are not found until necropsy. In patients with human immunode
[Adherence to very active antiretroviral treatment: impact of individualized assessment]: Enferm Infecc Microbiol Clin. 1999 Feb;17(2):78-81. Unique Identifier : AIDSLINE MED/99209147; Knobel H; Carmona A; Lopez JL; Gimeno JL; Saballs P; Gonzalez A; Guelar A; Diez A; Servicio de Medicina Interna-Infecciosas, Hospital del Mar,; Universidad Autonoma de Barcelona. hernando@intercom.es; BACKGROUND: To determine if the intervention of individual advice improves adherence and effectiveness to highly active antiretroviral therapy. METHODS: Randomized open trial. Patients treated with zidovudine + lamivudine + indinavir were assigned (2/
Inhibition of human immunodeficiency virus type 1 by Tat/Rev-regulated expression of cytosine deaminase, interferon alpha2, or diphtheria toxin compared with inhibition by transdominant Rev.: Hum Gene Ther. 1999 Jan 1;10(1):103-12. Unique Identifier : AIDSLINE MED/99145133; Ragheb JA; Couture L; Mullen C; Ridgway A; Morgan RA; National Institutes of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, MD 20892, USA.; A retroviral vector was designed to express toxic proteins only in the presence of the HIV-1 Rev and/or Tat protein(s). The design of this vector incorporates an HIV-specific expression cassette that consists of three elements: the U3R region of the HIV-1 IIIB LTR provides the promoter and Tat-responsive element, a mo
Generation of retroviral vector for clinical studies using transient transfection.: Hum Gene Ther. 1999 Jan 1;10(1):123-32. Unique Identifier : AIDSLINE MED/99145135; Yang S; Delgado R; King SR; Woffendin C; Barker CS; Yang ZY; Xu L; Nolan GP; Nabel GJ; Department of Internal Medicine, University of Michigan Medical; Center, Ann Arbor 48109-0650, USA.; Transient transfection of 293T cells was utilized to produce high-titer murine recombinant retroviral vectors for clinical studies. This system was initially optimized by gene transfer using different retroviral envelope proteins into activated human CD4+ T lymphocytes in vitro. Higher titer and infectivity were obtai
Green fluorescent protein as a selectable marker of fibronectin-facilitated retroviral gene transfer in primary human T lymphocytes.: Hum Gene Ther. 1999 Jan 1;10(1):5-14. Unique Identifier : AIDSLINE MED/99145124; Dardalhon V; Noraz N; Pollok K; Rebouissou C; Boyer M; Bakker AQ; Spits H; Taylor N; Institut de Genetique Moleculaire de Montpellier, Universite; Montpellier II, France.; The success of gene therapy strategies for congenital and acquired blood disorders requires high levels of gene transfer into hematopoietic cells. Retroviral vectors have been extensively used to deliver foreign genes to mammalian cells and improvement of transduction protocols remains dependent on markers that can be
Targeting retroviral vectors to CD34-expressing cells: binding to CD34 does not catalyze virus-cell fusion.: Hum Gene Ther. 1999 Mar 1;10(4):545-57. Unique Identifier : AIDSLINE MED/99191986; Benedict CA; Tun RY; Rubinstein DB; Guillaume T; Cannon PM; Anderson WF; Gene Therapy Laboratories, Norris Cancer Center, University of; Southern California School of Medicine, Los Angeles 90033, USA.; We have attempted to engineer murine leukemia virus (MuLV)-based retroviral vectors to specifically transduce cells expressing human CD34, an antigen present on the surface of undifferentiated hematopoietic stem cells. A number of chimeric ecotropic MuLV envelope (Env) proteins were constructed that contained anti-CD3
Human immunodeficiency virus infection and female lower genital tract malignancy.: Curr Opin Obstet Gynecol. 1999 Feb;11(1):35-9. Unique Identifier : AIDSLINE MED/99157491; Kuhn L; Sun XW; Wright TC Jr; Gertrude H. Sergievsky Center, Columbia University, New York, NY,; USA.; The risk of lower genital tract neoplasia is increased in women infected with HIV. This has been best demonstrated in cervical squamous intraepithelial lesions, but has also been observed in vulvar and perianal intraepithelial lesions in some studies. Alterations in the prevalence and natural history of human papillom
Optimization of the production of virus-like particles in insect cells.: Biotechnol Bioeng. 1998 Nov 20;60(4):408-18. Unique Identifier : AIDSLINE MED/99201242; Cruz PE; Cunha A; Peixoto CC; Clemente J; Moreira JL; Carrondo MJ; Instituto de Biologia Experimental e Tecnologica/Instituto de; Tecnologia Quimica e Biologica IBET/ITQB, Apartado 12, P-2780; Oeiras, Portugal.; In this work the maximal operational hydrodynamic conditions (agitation and aeration rate) that cause no adverse effect in Sf-9 cells growth in SF900II serum-free medium were determined. Shear stresses higher than 1 N m-2 and aeration rates higher than 0.04 vvm affect cell growth and when these conditions increase to
A CD4-independent interaction of human immunodeficiency virus-1 gp120 with CXCR4 induces their cointernalization, cell signaling, and T-cell chemotaxis.: Blood. 1999 Apr 15;93(8):2454-62. Unique Identifier : AIDSLINE MED/99211928; Misse D; Cerutti M; Noraz N; Jourdan P; Favero J; Devauchelle G; Yssel H; Taylor N; Veas F; Laboratoire d'Immunologie Retrovirale et Moleculaire, Institut; de Recherches pour le Developpement, Montpellier, France.; The gp120 envelope glycoprotein of human immunodeficiency virus-1 (HIV-1) interacts with the CXCR4 chemokine receptor, but it is not known whether gp120 activates CXCR4-mediated signaling cascades in the same manner as its natural ligand, SDF1alpha. We assessed the effects of wild-type gp120 and a mutant gp120 that in
Immunization with recombinant human granulocyte-macrophage colony-stimulating factor as a vaccine adjuvant elicits both a cellular and humoral response to recombinant human granulocyte-macrophage colony-stimulating factor.: Blood. 1999 Apr 15;93(8):2653-9. Unique Identifier : AIDSLINE MED/99211951; McNeel DG; Schiffman K; Disis ML; Division of Oncology, University of Washington, Seattle, WA, USA.; Granulocyte-macrophage colony-stimulating factor (GM-CSF) is an important cytokine for the generation and propagation of antigen-presenting cells and for priming a cellular immune response. We report here that use of recombinant human GM-CSF (rhGM-CSF), administered as an adjuvant in a peptide-based vaccine trial give
Detection of human herpesvirus-8 and Epstein-Barr virus DNA in primary intraocular lymphomas [letter]: Unique Identifier : AIDSLINE MED/99241747; Chan CC; Shen DF; Whitcup SM
The tat protein of HIV-1 induces galectin-3 expression.: Glycobiology. 1999 Apr;9(4):383-7. Unique Identifier : AIDSLINE MED/99190659; Fogel S; Guittaut M; Legrand A; Monsigny M; Hebert E; Glycobiology, Centre de Biophysique Moleculaire, UPR no. 4301 du; CNRS conventionnee avec l'Universite d'Orleans, Rue Charles; Sadron, 45071 Orleans Cedex 2, France.; Animal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates. Galectin-3 is a beta-galactoside-binding lectin whose expression is associated with various pathological processes including human T lymphotropic virus (HTLV)-I-infection of human T cell lines and human i
Overexpression and purification of an immunologically reactive His-BIV capsid fusion protein.: Protein Expr Purif. 1999 Apr;15(3):258-64. Unique Identifier : AIDSLINE MED/99194623; Betemps D; Mallet F; Cheynet V; Baron T; Centre National d'Etudes Veterinaires et Alimentaires, Lyon,; France.; The gene of the capsid protein of bovine immunodeficiency virus (BIV) was linked to a sequence encoding for six histidines and expressed as the (His)6 p26 capsid fusion protein. The fusion protein was strongly expressed as both soluble and insoluble forms after induction by isopropylthio-beta-d-galactoside. Purificati
Apoptotic effect of outer-membrane proteins from Campylobacter jejuni on chicken lymphocytes.: Curr Microbiol. 1999 Apr;38(4):244-9. Unique Identifier : AIDSLINE MED/99169031; Zhu J; Meinersmann RJ; Hiett KL; Evans DL; Poultry Microbiological Safety Research Unit, Russell; Agricultural Research Center, U.S. Department of Agriculture,; Agricultural Research Service, Athens, GA 30604.; Campylobacter jejuni is a significant cause of food-borne diseases in humans. The bacterium is considered a commensal organism in chickens, and it can heavily colonize chickens without causing inflammation. Poultry may be the major reservoir for the human infection in developed countries. Here we show that an outer-me
Action of a new mammalian DNA polymerase inhibitor, sulfoquinovosyldiacylglycerol.: Biol Pharm Bull. 1999 Feb;22(2):111-6. Unique Identifier : AIDSLINE MED/99175044; Ohta K; Mizushina Y; Hirata N; Takemura M; Sugawara F; Matsukage A; Yoshida S; Sakaguchi K; Department of Applied Biological Science, Faculty of Science and; Technology, Science University of Tokyo, Chiba, Japan.; We found and previously reported a new mammalian DNA polymerase inhibitor from a sea alga, Gigartina tenella, (Ohta K., et al., Chem. Pharm. Bull., 46, 684-686, 1998). It was a new sulfolipid compound that belonged in the class of sulfoquinovosyldiacylglycerol. The biochemical properties have been investigated here. T
Adverse drug reactions (ADRs) in patients with HIV infection. A prospective study.: Int J Clin Pharmacol Ther. 1999 Jan;37(1):34-40. Unique Identifier : AIDSLINE MED/99149727; Gonzalez-Martin G; Yanez CG; Gonzalez-Contreras L; Labarca J; Department of Pharmacy, Faculty of Chemistry, Pontifical Catholic; University of Chile, Santiago.; AIM: A prospective drug surveillance method was used to monitor 50 ambulatory patients with HIV infection, who were controlled in the Sexual Transmission Disease Service at Dr. Sotero del Rio Hospital (Santiago, Chile ). The aim of this work was to characterize and study the frequenc
Assessment of the quality of life of patients with advanced and end-stage cancer or serious infections with a symptom-based or an impact-based instrument.: Support Care Cancer. 1999 Mar;7(2):64-70. Unique Identifier : AIDSLINE MED/99186945; Witteveen PO; Jacobs HM; van Groenestijn MA; Lodder AC; van Boxtel AH; Nieuwland M; Post MW; Touw-Otten FW; Blijham GH; Department of Internal Medicine, Section of Oncology, University; Hospital Utrecht, The Netherlands. P.O.Witteveen@digd.azu.nl; In 1992 a project was started in which home care technology was made available to patients with cancer or serious infections. Primary care providers were trained and supported to administer parenteral drugs and fluids in the home setting. Between 1992 and 1995 we applied the Rotterdam Symptom Checklist (RSCL) and the
New tricks for modelers from the crystallography toolkit: the particle mesh Ewald algorithm and its use in nucleic acid simulations.: Structure. 1999 Mar 15;7(3):R55-60. Unique Identifier : AIDSLINE MED/99197302; Darden T; Perera L; Li L; Pedersen L; National Institute of Environmental Health Science, Box 12233,; MD-F008, RTP, NC 27709, USA. darden@niehs.nih.gov
HIV-1-infection in the CNS. A pathogenesis of some neurological syndromes in the light of recent investigations.: Folia Neuropathol. 1998;36(4):211-6. Unique Identifier : AIDSLINE MED/99179319; Rafalowska J; Department of Neurology, School of Medicine, Warszawa.; The main factors in the pathogenesis of AIDS- dementia complex (ADC) are analyzed. The author suggests that these factors can be divided into two groups. The nonspecific factors present in every immunologic processes manifested by inflammation compose the first group. They are cyt
Progressive multifocal leukoencephalopathy (PML) and cerebral toxoplasmosis in an adult patient, with no symptoms of underlying immunosuppressing illness.: Folia Neuropathol. 1998;36(4):229-34. Unique Identifier : AIDSLINE MED/99179323; Bertrand E; Lewandowska E; Nerurkar V; Bratosiewicz J; Yanagihara R; Zaborski J; Liberski PP; Department of Neuropathology, Institute of Psychiatry and; Neurology, Warszawa.; We present a case of the coincidence of progressive multifocal leukoencephalopathy (PML) and central nervous system (CNS) toxoplasmosis in an adult patient, without a detectable cause of cell-mediated immunity impairment. The proper diagnosis was made postmortem on the basis of histological changes typical of both pat
Opportunistic thoracic infections. Bacteria, viruses, and protozoa.: Chest Surg Clin N Am. 1999 Feb;9(1):167-92, ix-x. Unique Identifier : AIDSLINE MED/99179722; Talbot EA; Hicks CB; Department of Medicine, Duke University Medical Center, Durham,; North Carolina, USA.; The range of potential bacterial, viral, and protozoan pathogens that can cause pulmonary infections in immunocompromised patients is extensive. An aggressive diagnostic approach is essential to maximizing chances for a successful outcome. This article discusses the general diagnostic approach and provides a discussio
The initial pulmonary evaluation of the immunocompromised patient.: Chest Surg Clin N Am. 1999 Feb;9(1):19-38. Unique Identifier : AIDSLINE MED/99179714; Walsh FW; Rolfe MW; Rumbak MJ; Division of Pulmonary and Critical Care Medicine, University of; South Florida College of Medicine, Tampa, USA.; Practical approaches to the initial evaluation of solid organ transplant patients, BMT patients, and HIV-infected patients with pulmonary disease are summarized in Figures 2, 3, and 4. These algorithms are meant to be used as guidelines for the clinician. The clinical setting will ultimately determine the extent and s
Mycobacterium tuberculosis and other mycobacteria.: Chest Surg Clin N Am. 1999 Feb;9(1):227-38, x. Unique Identifier : AIDSLINE MED/99179724; Mault JR; Pomerantz M; University of Colorado Health Sciences Center, Denver, USA.; The immunocompromised post-transplant HIV-positive patient is at increased risk for mycobacterial infection. Early diagnosis and aggressive therapy is critical to successful outcome. Surgical therapy may be required in patients who have complex mycobacterial lung disease, drug resistant tuberculosis, or mycobacterial
Malignancies associated with the immunocompromised state.: Chest Surg Clin N Am. 1999 Feb;9(1):63-77, viii. Unique Identifier : AIDSLINE MED/99179716; Katariya K; Thurer RJ; Thoracic Surgery Section, University of Miami School of Medicine,; Florida, USA.; Neoplastic disease occurs more frequently in immunocompromised patients than in the general population. These tumors occur at an earlier age and behave more aggressively. Their origin is linked to viral infection and other causes of immunodeficiency, such as antirejection drugs. Despite aggressive therapy, these patie
The thoracic surgeon's role in the management of patients with HIV infection and AIDS.: Chest Surg Clin N Am. 1999 Feb;9(1):97-111. Unique Identifier : AIDSLINE MED/99179718; DiMaio JM; Wait MA; Division of Thoracic and Cardiovascular Surgery, University of; Texas, Southwestern Medical Center, Dallas, USA.; michael.dimaio@email.swmed.edu; The advent of improved medical therapy with multidrug HIV medicines including protease inhibitors has prolonged life expectation of patients with HIV infection. The risk of perinatal transmission has also decreased with education and antiviral medications. Education
Interleukin-12 gene transfer results in CD8-dependent regression of murine CT26 liver tumors.: Ann Surg Oncol. 1999 Mar;6(2):186-94. Unique Identifier : AIDSLINE MED/99180082; Weber SM; Shi F; Heise C; Warner T; Mahvi DM; Department of Surgery, University of Wisconsin School of; Medicine, Madison, USA.; BACKGROUND: Interleukin (IL)-12 has potent antitumor effects in animal models. We hypothesized that direct transfer of the IL-12 gene to established tumors would result in tumor regression without significant toxicity. METHODS: Liver tumors were established by direct injection of CT26, a murine adenocarcinoma, into th
Syringe sales by pharmacies reviewed as HIV-prevention strategy [news]: Am J Health Syst Pharm. 1999 Jan 1;56(1):16. Unique Identifier : AIDSLINE MED/99239688
Simultaneous use of two protease inhibitors in HIV infection.: Am J Health Syst Pharm. 1999 Feb 1;56(3):273-6. Unique Identifier : AIDSLINE MED/99153589; Varav H; Holtzer CD; Chartwell Care Management, Brown & Toland Medical Group, San; Francisco, California, USA.
Cytokine molecular adjuvants modulate immune responses induced by DNA vaccine constructs for HIV-1 and SIV.: J Interferon Cytokine Res. 1999 Jan;19(1):77-84. Unique Identifier : AIDSLINE MED/99156558; Kim JJ; Simbiri KA; Sin JI; Dang K; Oh J; Dentchev T; Lee D; Nottingham LK; Chalian AA; McCallus D; Ciccarelli R; Agadjanyan MG; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104-6100, USA.; DNA or nucleic acid immunization has been shown to induce both antigen-specific cellular and humoral immune responses in vivo. Moreover, immune responses induced by DNA immunization can be enhanced and modulated by the use of molecular adjuvants. To further engineer the immune response in vivo, we investigated the ind
A method for biomolecular structural recognition and docking allowing conformational flexibility.: J Comput Biol. 1998 Winter;5(4):631-54. Unique Identifier : AIDSLINE MED/99170297; Sandak B; Nussinov R; Wolfson HJ; Department of Applied Mathematics and Computer Science, Weizmann; Institute of Science, Rehovot, Israel.; billie@wisdom.weizmann.ac.il; In this work, we present an algorithm developed to handle biomolecular structural recognition problems, as part of an interdisciplinary research endeavor of the Computer Vision and Molecular Biology fields. A key problem in rational drug design and in biomolecular structural recognition is the generation of binding mo
World AIDS Day [news]: J Can Dent Assoc. 1999 Jan;65(1):12. Unique Identifier : AIDSLINE MED/99139165
The law and ethics in relation to dentists treating HIV-positive patients: report on a recent U.S. Supreme Court case.: J Can Dent Assoc. 1999 Jan;65(1):27-30. Unique Identifier : AIDSLINE MED/99139166; Graham PE; Harel-Reviv M; Sir Mortimer Davis Jewish General Hospital, Department of; Dentistry, Montreal.; The U.S. Supreme Court confirms that an HIV-seropositive patient is a handicapped person even if totally asymptomatic. Hence, the patient is illegally discriminated against if a dentist consequently refuses to treat the person in the same manner in which he or she treats other patients. Canadian dental care provider
[Hemopoietic cells from human embryonic liver in the treatment of HIV/AIDS]: Lik Sprava. 1998 Dec;(8):116-8. Unique Identifier : AIDSLINE MED/99220578; Pylypchak OM; Transplantation of human fetal liver cells is used for the deficient cellular mediators and humoral immunological factors to be efficiently replenished through proliferation and differentiation of embryonic stem cells contained in cellular suspensions. Kept under hospital observation were 17 patients: two female patie
The Tennessee HIV Pregnancy Screening Act of 1997.: Tenn Med. 1999 Apr;92(4):141-2. Unique Identifier : AIDSLINE MED/99210887; Moore WL Jr; Tennessee Department of Health, Nashville, USA.
Human immunodeficiency virus negative Kaposi sarcoma and lymphoproliferative disorders.: Cancer. 1999 Apr 1;85(7):1611-5. Unique Identifier : AIDSLINE MED/99208297; Fossati S; Boneschi V; Ferrucci S; Brambilla L; Institute of Dermatology, State University, IRCCS Ospedale; Policlinico, Milan, Italy.; BACKGROUND: The concomitant occurrence of more than one primary neoplasm in the same individual has led researchers to seek possible common etiopathogenetic factors. Kaposi sarcoma (KS) is a multicentric neoplasm of vascular origin and perhaps viral etiology. Four forms of KS are known: classic or Mediterranean, endem
Imaging pulmonary disease in AIDS: state of the art.: Eur Radiol. 1999;9(3):395-408. Unique Identifier : AIDSLINE MED/99187359; Kuhlman JE; Department of Radiology, University of Wisconsin-Madison, Medical; School, E3/311 Clinical Science Center, 600 Highland Avenue,; Madison, WI 53792-3252, USA.; The spectrum of pulmonary diseases in AIDS including infections and neoplasms that affect the lungs are reviewed. Characteristic plain film and CT findings are illustrated.
Factors related to family therapists' breaking confidence when clients disclose high-risks-to-HIV/AIDS sexual behaviors.: J Marital Fam Ther. 1998 Oct;24(4):457-72. Unique Identifier : AIDSLINE MED/99018813; Pais S; Piercy F; Miller JA; Indiana University/Methodist/Clarian Family Practice Residency; Program, Indianapolis 46202-1261, USA.; This national survey of 309 marriage and family therapists examined what therapists do when their HIV-positive clients disclose that they are engaging in high-risk sexual behavior. The participants were given vignettes in which a fictitious client told the therapist about engaging in unprotected sex. Although the basi
Link between HIV risk and other STDs debated at forum.: CMAJ. 1999 Apr 6;160(7):1048. Unique Identifier : AIDSLINE MED/99223756; Silversides A
Stem Trace: an interactive visual tool for comparative RNA structure analysis.: Bioinformatics. 1999 Jan;15(1):16-31. Unique Identifier : AIDSLINE MED/99169316; Kasprzak W; Shapiro B; Intramural Research Support Program, SAIC Frederick, National; Cancer Institute/FCRDC, Bldg 469, Rm 150C, MD 21702, USA.; kasprzak@ncifcrf.gov; MOTIVATION: Stem Trace is one of the latest tools available in STRUCTURELAB, an RNA structure analysis computer workbench. The paradigm used in STRUCTURELAB views RNA structure determination as a problem of dealing with a database of a large number of computationally generated structures. Stem Trace provides the capab
Outbreak of multiple drug-resistant tuberculosis in Lisbon: detection by restriction fragment length polymorphism analysis.: Int J Tuberc Lung Dis. 1999 Mar;3(3):207-13. Unique Identifier : AIDSLINE MED/99192134; Portugal I; Covas MJ; Brum L; Viveiros M; Ferrinho P; Moniz-Pereira J; David H; Departamento de Microbiologia, Faculdade de Farmacia de; Universidade de Lisboa, Portugal. isabel.portugal@ff.ul.pt; SETTING: Multidrug-resistant tuberculosis (MDR-TB) mainly among human immunodeficiency virus (HIV) seropositive patients in Lisbon hospitals in 1996-1997. OBJECTIVE: Detection of transmission of MDR-TB strains and epidemic outbreaks in several hospital units in the city of Lisbon, including a prison hospital. DESIGN:
Phase II trial of recombinant interferon-alpha2b in patients with advanced intractable multidrug-resistant pulmonary tuberculosis: long-term follow-up.: Int J Tuberc Lung Dis. 1999 Mar;3(3):214-8. Unique Identifier : AIDSLINE MED/99192135; Palmero D; Eiguchi K; Rendo P; Castro Zorrilla L; Abbate E; Gonzalez Montaner LJ; Institute of Pulmonary Diseases, University of Buenos Aires,; Argentina.; SETTING: Multidrug-resistant tuberculosis patients without human immunodeficiency virus (HIV) infection, with Mycobacterium tuberculosis resistant to almost all of the available drugs. OBJECTIVE: Limited phase II trial with recombinant interferon-alpha2b in five chronic multidrug-resistant tuberculosis patients. METHO
Evaluation of the MycoDot test in patients with suspected tuberculosis in a field setting in Tanzania.: Int J Tuberc Lung Dis. 1999 Mar;3(3):231-8. Unique Identifier : AIDSLINE MED/99192138; Somi GR; O'Brien RJ; Mfinanga GS; Ipuge YA; National Institute for Medical Research, Dar Es Salaam, Tanzania.; SETTING: Rapid, simple and inexpensive methods are needed to improve the diagnosis of tuberculosis in low-income countries. The MycoDot test has these characteristics. OBJECTIVE: To assess the utility of the MycoDot test in screening patients with suspected tuberculosis. DESIGN: Ambulatory patients presenting with sym
The immune response to Mycobacterium tuberculosis in HIV-infected and uninfected adults in Uganda: application of a whole blood cytokine assay in an epidemiological study.: Unique Identifier : AIDSLINE MED/99192139; Elliott AM; Hurst TJ; Balyeku MN; Quigley MA; Kaleebu P; French N; Biryahwaho B; Whitworth JA
Tuberculosis vaccination versus isoniazid preventive therapy: a decision analysis to determine the preferred strategy of tuberculosis prevention in HIV-infected adults in the developing world.: Int J Tuberc Lung Dis. 1999 Mar;3(3):248-54. Unique Identifier : AIDSLINE MED/99192140; Sterling TR; Brehm WT; Moore RD; Chaisson RE; Department of Medicine, Keesler Medical Center, Keesler AFB,; Mississippi, USA. tsterls@welchlink.welch.jhu.edu; SETTING: The developing world. OBJECTIVE: To compare the strategy of TB vaccination with that of tuberculin skin-testing in conjunction with isoniazid (INH) in preventing tuberculosis in HIV-infected persons. For any clinical scenarios in which immunization would be more effective than INH preventive therapy, to deter
The effects of BCG immunization and human immunodeficiency virus infection on dual skin test reactions to purified protein derivative and Mycobacterium avium sensitin among adults in Zambia.: Int J Tuberc Lung Dis. 1999 Mar;3(3):255-60. Unique Identifier : AIDSLINE MED/99192141; Waddell RD; von Reyn CF; Baboo KS; Mwinga A; Chintu C; Zumla A; Infectious Disease Section, Dartmouth-Hitchcock Medical Center; and Dartmouth Medical School, Lebanon, New Hamshire 03756, USA.; SETTING: University hospital in Lusaka, Zambia . OBJECTIVE: To determine the effects of childhood bacille Calmette-Guerin (BCG) immunization and human immunodeficiency virus (HIV) infection on dual skin test reactions to purified protein derivative (PPD) and Mycobacterium avium sens
Efficacy and safety of combination therapy with delavirdine and zidovudine: a European/Australian phase II trial.: Int J Antimicrob Agents. 1999 Jan;11(1):13-21. Unique Identifier : AIDSLINE MED/99173595; Been-Tiktak AM; Boucher CA; Brun-Vezinet F; Joly V; Mulder JW; Jost J; Cooper DA; Moroni M; Gatell JM; Staszewski S; Colebunders R; Stewart GJ; Hawkins DA; Johnson MA; Parkin JM; Kennedy DH; Hoy JF; Borleffs JC; Department of Internal Medicine, Eijkman-Winkler Institute of; Medical Microbiology, University Hospital, Utrecht, The; Netherlands.; The objective of the study was to investigate the safety and antiviral effect of three delavirdine dose regimens or placebo in combination with zidovudine in patients who were already taking zidovudine. Eighty-nine symptomatic HIV-1 seropositive indiv
Murine class I major histocompatibility complex H-2Dd: expression, refolding and crystallization.: Acta Crystallogr D Biol Crystallogr. 1999 Jan;55 ( Pt 1):260-2. Unique Identifier : AIDSLINE MED/99190854; Achour A; Harris RA; Persson K; Sundback J; Sentman CL; Schneider G; Lindqvist Y; Karre K; Microbiology and Tumorbiology Center, Karolinska Institutet,; Stockholm, Sweden.; A truncated soluble form of the murine class I major histocompatibility antigen complex H-2Dd was cloned using an Escherichia coli based system. It was expressed, refolded in vitro and crystallized in a complex with murine beta2 microglobulin and the peptide RGPGRAFVTI from the V3-loop of the gp160 HIV-1 protein. Crys
Crystallization of the dimerization-initiation site of genomic HIV-1 RNA: preliminary crystallographic results.: Unique Identifier : AIDSLINE MED/99190861; Yusupov M; Walter P; Marquet R; Ehresmann C; Ehresmann B; Dumas P; Institut de Biologie Moleculaire et Cellulaire du CNRS,; UPR900215, rue Rene Descartes, F67084 Strasbourg CEDEX, France.; The genomic RNA of all retroviruses is encapsidated in virions as a dimer of single-stranded chains held together near their 5 -end. For HIV-1, the initial site of dimerization has been shown to be a hairpin with a nine-residue loop containing a self-complementary sequence of six residues. This structure is proposed t
Structures of the HIV-1 capsid protein dimerization domain at 2.6 A resolution.: Acta Crystallogr D Biol Crystallogr. 1999 Jan;55 ( Pt 1):85-92. Unique Identifier : AIDSLINE PDB/1BAJ; Worthylake DK; Wang H; Yoo S; Sundquist WI; Hill CP; Biochemistry Department, University of Utah Medical School, 50; North Medical Drive, Salt Lake City, Utah 84132, USA.; The human immunodeficiency virus type I (HIV-1) capsid protein is initially synthesized as the central domain of the Gag polyprotein, and is subsequently proteolytically processed into a discrete 231-amino-acid protein that forms the distinctive conical core of the mature virus. The crystal structures of two proteins
Antiretroviral treatment and travel to developing countries.: J Travel Med. 1999 Mar;6(1):27-31. Unique Identifier : AIDSLINE MED/99170764; Colebunders R; Nachega J; Van Gompel A; Institute of Tropical Medicine, Department of Clinical Sciences,; Antwerpen, Belgium. bcoleb@itg.be
Sexually transmitted diseases, unintended pregnancy, and adolescent health promotion.: Adolesc Med. 1999 Feb;10(1):87-108, vi. Unique Identifier : AIDSLINE MED/99186087; Santelli JS; DiClemente RJ; Miller KS; Kirby D; Division of Reproductive Health, Centers for Disease Control and; Prevention, Atlanta, GA 30341, USA.; Adolescence is a critical period in the development of sexual behaviors that may lead to acquiring sexually transmitted diseases (STDs), including human immunodeficiency virus (HIV), and to unintended pregnancy. Understanding adolescent sexual behavior is essential for understanding adolescents risk of pregnancy and
Enhanced HIV-1 envelope-tumor protection by a recombinant vaccinia virus expressing anchored HIV-1 gp120 lacking gp41.: Unique Identifier : AIDSLINE MED/99220801; Lie H; Wright SE; Medical Student 1, Texas Tech University Health Sciences Center,; Lubbock, TX 79430, USA.; A recombinant vaccinia virus (rvv) expressing, human immunodeficiency virus type 1 (HIV-1) external envelope glycoprotein, gp120, fused to a non-cleavable transmembrane protein, vvE13, elicited protection against a tumor cell line expressing HIV-1 full length envelope glycoprotein, gp160, in mice. Mice vaccinated with
Cell-dependent functional roles of HIV-1 Nef for virus replication (review).: Int J Mol Med. 1999 Apr;3(4):427-30. Unique Identifier : AIDSLINE MED/99220807; Adachi A; Oshima Y; Department of Virology, The University of Tokushima School of; Medicine, Tokushima 770-8503, Japan.; The stage in the human immunodeficiency virus type 1 (HIV-1) replication cycle that is affected by Nef has been investigated. Nef is dispensable during the transcription to virion production step. In contrast, Nef is critical in the early phase of the virus replication cycle, from virion adsorption to integration. Fur
Two cultures, two levels of AIDS risk.: Bull World Health Organ. 1999;77(3):278-80. Unique Identifier : AIDSLINE MED/99228992; Wang MS; Gao MY; Zhao J; Department of Psychology, Faculty of Science and Mathematics,; University of Newcastle, Callaghan, NSW, Australia.; pssw@cc.newcastle.edu.au; On the basis of a field survey the authors discuss strategy for reducing the relatively high incidence of HIV infection and AIDS among China s self-employed.
HIV stress in primary school teachers in Zambia.: Bull World Health Organ. 1999;77(3):284-7. Unique Identifier : AIDSLINE MED/99228994; Baggaley R; Sulwe J; Chilala M; Mashambe C; Department of Medicine, University of Teaching Hospital, Lusaka,; Zambia. baggaley@who.ch; A study was made of stress factors experienced by primary school teachers in Zambia after they had attended a course on stress management and counselling skills. Their pupils were significantly affected by poverty, death and illness of parents, fellow-pupils and teachers, teenage s
HIV/AIDS prevention-related social skills and knowledge among adolescents in Sierra Leone, West Africa.: Afr J Reprod Health. 1997 Mar;1(1):37-44. Unique Identifier : AIDSLINE MED/99231016; Lahai-Momoh JC; Ross MW; Center for Health Promotion Research and Development, School of; Public Health, University of Texas, Houston 77225, USA.; This study examined the association between HIV/AIDS knowledge, attitudes, and perceptions among high school students age 14 years and older who attended school in two large urban towns, Bo and Freetown, Sierra Leone , West Africa. All subjects in the survey were Africans in gr
Reproductive health issues in Africa [editorial]: Afr J Reprod Health. 1997 Mar;1(1):5-6. Unique Identifier : AIDSLINE MED/99231012; Rosenfield A
The condom conundrum: barriers to condom use among commercial sex workers in Durban, South Africa.: Afr J Reprod Health. 1997 Mar;1(1):74-88. Unique Identifier : AIDSLINE MED/99231020; Varga CA; Department of Social Anthropology, University of Natal, Durban,; South Africa.; We examined socio-cultural and economic determinants of condom use among 100 female South African commercial sex workers. The symbolism and dynamics of condom use between sex workers and their clientele were explored. These issues were also investigated when sex workers negotiated sex with their personal partners. An
Africa faces reproductive crisis [editorial]: Afr J Reprod Health. 1997 Sep;1(2):10-4. Unique Identifier : AIDSLINE MED/99231025; Caldwell JC
The socio-demographic impact of AIDS in Africa. 3-6 February 1997, Durban, South Africa.: Afr J Reprod Health. 1997 Sep;1(2):105-7. Unique Identifier : AIDSLINE MED/99231035; Pisani E
Workshop on family planning in the era of AIDS. Nairobi, Kenya, 2-4 October, 1996.: Afr J Reprod Health. 1997 Sep;1(2):110-3. Unique Identifier : AIDSLINE MED/99231037; Zaba B; Centre for Population Studies, London School of Hygiene and; Tropical Medicine, London, United Kingdom.
Sexually transmitted diseases and risk of HIV infection in men attending a sexually transmitted diseases clinic in Dakar, Senegal.: Afr J Reprod Health. 1997 Sep;1(2):26-35. Unique Identifier : AIDSLINE MED/99231027; Thior I; Diouf G; Diaw IK; Sarr AD; Hsieh CC; Ndoye I; Mboup S; Chen L; Essex M; Marlink R; Kanki P; Harvard AIDS Institute, Harvard School of Public Health, Boston; 02115, USA.; This cross-sectional study was carried out among male outpatients with symptoms of STDs at the STD reference centre at the Institute of Social Hygiene (IHS), Dakar, Senegal , from March 1989 through May 1991. This study was used to determine the prevalence of STDs and HIV among mal
HIV seroprevalence in women of childbearing age in Benin City, Nigeria.: Afr J Reprod Health. 1997 Sep;1(2):36-40. Unique Identifier : AIDSLINE MED/99231028; Offor E; Okolo AA; Faculty of Medicine, Department of Medical Microbiology,; University of Benin, Nigeria.; HIV seroprevalence was still low in some parts of Nigeria from 1989 to 1991, and only limited reports were available on seroprevalence in childbearing women. In order to assess HIV seroprevalence in pregnant women in Benin City and Bendel State,
Violence against women in Sierra Leone: frequency and correlates of intimate partner violence and forced sexual intercourse.: Afr J Reprod Health. 1998 Apr;2(1):61-72. Unique Identifier : AIDSLINE MED/99231045; Coker AL; Richter DL; Department of Epidemiology and Biostatistics, University of South; Carolina, School of Public Health, Columbia 29208, USA.; Violence against women is a significant public health problem which impacts women, men, and children. Little is known about the frequency or correlates of violence against women in Africa. In this cross-sectional study, we found that 66.7% of 144 women surveyed in a study of AIDS knowledge, attitude, and behaviours, r
Strengthening STD/HIV/AIDS work in the framework of sexual-reproductive health/family planning projects. 29 January 1998, Heidelberg.: Afr J Reprod Health. 1998 Apr;2(1):90-4. Unique Identifier : AIDSLINE MED/99231049; Dehne KL; Department of Tropical Hygiene and Public Health, Medical School,; University of Heidelberg, Germany.
Cytokine responses in virus infections: effects on pathogenesis, recovery and persistence.: Curr Opin Microbiol. 1998 Aug;1(4):411-8. Unique Identifier : AIDSLINE MED/99185243; Estcourt MJ; Ramshaw lA; Ramsay AJ; Division of Immunology, John Curtin School of Medical Research,; Australian National University, PO Box 334, Canberra ACT 2601,; Australia. Marie.Estcourt@anu.edu.au; During the past year, significant advances have been made in our understanding of cytokine regulation and the respective roles played by T helper cells type 1 and 2 immune responses during virus infection. Numerous mechanisms by which viruses may evade host immune defences have now been identified, some directly influ
The new numerology of immunity mediated by virus-specific CD8(+) T cells.: Curr Opin Microbiol. 1998 Aug;1(4):419-22. Unique Identifier : AIDSLINE MED/99185244; Doherty PC; Department of Immunology, St Jude Children's Research Hospital,; 332 North Lauderdale, Memphis, TN 38105, USA.; peter.doherty@stjude.org; Our understanding of virus-specific CD8(+) T cell responses is currently being revolutionized by peptide-based assay systems that allow flow cytometric analysis of effector and memory cytotoxic T lymphocyte populations. These techniques are, for the first time, putting the analysis of T-cell-mediated immunity on a qua
HIV pathogenesis: mechanisms of susceptibility and disease progression.: Curr Opin Microbiol. 1998 Aug;1(4):423-9. Unique Identifier : AIDSLINE MED/99185245; Simonsen JN; Fowke KR; MacDonald KS; Plummer FA; Departments of Medical Microbiology, University of Manitoba,; Winnipeg Manitoba R3E 0W3, Canada. jsimons@ms.umanitoba.ca; The understanding of the factors associated with HIV-1 acquisition and disease progression has been significantly advanced in the past few years. These factors can be broadly defined as intrinsic or acquired and are operative at the levels of disease acquisition and progression or both. Much recent attention has focus
HIV-1, HHV-8, and Kaposi's sarcoma [editorial; comment]: J Hum Virol. 1998 Mar-Apr;1(3):185-6. Unique Identifier : AIDSLINE MED/99211144; Gallo RC
Inheritance pattern of mutant human immunodeficiency virus type 1 coreceptor gene CCR5 in an Indian family.: J Hum Virol. 1998 Mar-Apr;1(3):187-92. Unique Identifier : AIDSLINE MED/99211145; Husain S; Goila R; Shahi S; Banerja AC; Department of Microbiology, Guru Nanak Dev University, Amritsar,; India.; The most common form of mutation found in the CCR5 gene has been the precise 32-base pair (bp) deletion in the region corresponding to second extracellular loop of the chemokine receptor CCR5. Individuals homozygous for the delta 32 allele of CCR5 usually remain uninfected despite multiple exposures to HIV, whereas he
Kaposi's sarcoma in the Gambia, West Africa is less frequent in human immunodeficiency virus type 2 than in human immunodeficiency virus type 1 infection despite a high prevalence of human herpesvirus 8 [see comments]: J Hum Virol. 1998 Mar-Apr;1(3):193-9. Unique Identifier : AIDSLINE MED/99211146; Ariyoshi K; Schim van der Loeff M; Cook P; Whitby D; Corrah T; Jaffar S; Cham F; Sabally S; O'Donovan D; Weiss RA; Schulz TF; Whittle H; Medical Research Council Laboratories, The Gambia, West Africa.; kariyoshi@gam.healthnet.org; OBJECTIVES: To investigate the distribution of Kaposi s sarcoma (KS) cases in patients with human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) infection in the Gambia ; to document the prevalence of human herpesvirus 8 (HHV-8) infection in various population groups in the
JC virus type 2B is found more frequently in brain tissue of progressive multifocal leukoencephalopathy patients than in urine from controls.: J Hum Virol. 1998 Mar-Apr;1(3):200-6. Unique Identifier : AIDSLINE MED/99211147; Agostini HT; Ryschkewitsch CF; Singer EJ; Baumhefner RW; Stoner GL; Neurotoxicology Section, National Institute of Neurological; Disorders and Stroke, National Institutes of Health, Bethesda,; Maryland 20892, USA.; OBJECTIVES: Previous studies have shown that strains of human polyomavirus JC (JCV) of Asian origin (type 2) are much more highly represented in progressive multifocal leukoencephalopathy (PML) brain than would be expected from their frequency of excretion in urine samples of a comparable control group. The present st
Seroprevalence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 in several regions of Italy.: J Hum Virol. 1998 Mar-Apr;1(3):207-13. Unique Identifier : AIDSLINE MED/99211148; Calabro ML; Sheldon J; Favero A; Simpson GR; Fiore JR; Gomes E; Angarano G; Chieco-Bianchi L; Schulz TF; Department of Oncology and Surgical Sciences, University of; Padova, Italy. lcalabro@ux1.unipd.it; OBJECTIVE: To study the seroprevalence of Kaposi s sarcoma-associated herpesvirus/human herpesvirus type 8 (KSHV/HHV-8) in 779 Italian blood donors. STUDY DESIGN/METHODS: Sera were tested for antibodies to a latency-associated nuclear antigen (LANA) and a capsid related protein encoded by ORF65. RESULTS: Among all Ita
Mammary epithelial cells support and transfer productive human T-cell lymphotropic virus infections.: J Hum Virol. 1998 Mar-Apr;1(3):214-23. Unique Identifier : AIDSLINE MED/99211149; LeVasseur RJ; Southern SO; Southern PJ; Department of Microbiology, University of Minnesota, Minneapolis; 55455, USA.; OBJECTIVES: To investigate whether luminal and basal human mammary epithelial cells (HMEC) are susceptible to productive infection by human T-cell lymphotropic virus types I and II (HTLV-I and HTLV-II) and whether HTLV infection of breast epithelial cells could contribute to the seeding of milk with HTLV infectivity a
Evolution of human immunodeficiency virus type 1 in relation to disease progression in children.: J Hum Virol. 1998 Mar-Apr;1(3):224-39. Unique Identifier : AIDSLINE MED/99211150; Strunnikova N; Ray SC; Lancioni C; Nguyen M; Viscidi RP; Department of Pediatrics, Johns Hopkins University School of; Medicine, Baltimore, Maryland, USA.; OBJECTIVE: To compare patterns of nonsynonymous and synonymous substitutions over time in the V1V2 and C2V3 regions of human immunodeficiency virus type 1 (HIV-1) env and in a conserved segment of pol in HIV-1-infected children with varying rates of CD4+ T-cell decline. STUDY DESIGN/METHODS: Longitudinal study of HIV-
Cotransfection of mutated forms of human immunodeficiency virus type 1 Gag-Pol with wild-type constructs can interfere with processing and viral replication.: J Hum Virol. 1998 Mar-Apr;1(3):240-7. Unique Identifier : AIDSLINE MED/99211151; Morin N; Cherry E; Li X; Wainberg MA; McGill University AIDS Centre, Lady Davis Institute-Jewish; General Hospital, Montreal, Quebec, Canada.; OBJECTIVES: We wished to generate a number of genetic constructs containing mutations in the protease (PR) and reverse transcriptase (RT) genes of the Gag-Pol of human immunodeficiency virus type 1 (HIV-1) and to transfect these constructs into COS-7 cells to determine their effect on wild-type (wt) viral replication.
Superantigen-induced T cell responses in acute rheumatic fever and chronic rheumatic heart disease patients.: Clin Exp Immunol. 1999 Apr;116(1):100-6. Unique Identifier : AIDSLINE MED/99225987; Bhatnagar A; Grover A; Ganguly NK; Department of Experimental Medicine, Postgraduate Institute of; Medical Education and Research, Chandigarh, India.; CD4+ and CD8+ T cells from healthy donors, acute rheumatic fever (ARF) and chronic rheumatic heart disease (CRHD) patients responded variably to a superantigen from Streptococcus pyogenes--Streptococcal pyrogenic erythrogenic toxin A (SPE-A). In vitro culture of CD4+ T cells from ARF patients (CD4-ARF) with SPE-A exhi
IL-10 in HIV infection: increasing serum IL-10 levels with disease progression--down-regulatory effect of potent anti-retroviral therapy.: Clin Exp Immunol. 1999 Apr;116(1):115-20. Unique Identifier : AIDSLINE MED/99225989; Stylianou E; Aukrust P; Kvale D; Muller F; Froland SS; Section of Clinical Immunology and Infectious Diseases, Medical; Department A, Rikshospitalet, Oslo, Norway.; To examine the potential pathogenic role of IL-10 in HIV infection, we measured serum IL-10 levels in 51 HIV-infected patients and 23 healthy controls both on cross-sectional and longitudinal testing. All clinical groups (Centers for Disease Control (CDC) categories) of HIV-infected patients had significantly higher c
Increased bcl-2 expression in lymphocytes and its association with hepatocellular damage in patients with autoimmune hepatitis.: Clin Exp Immunol. 1999 Apr;116(1):140-5. Unique Identifier : AIDSLINE MED/99225993; Yachida M; Kurokohchi K; Arima K; Nishioka M; Third Department of Internal Medicine, Kagawa Medical University,; Japan.; The proto-oncogene product bcl-2 is known to inhibit apoptotic cell death, and its dysregulation might play a critical role in the development of autoimmune disease. To elucidate the role of bcl-2 in autoimmune hepatitis (AIH), its expression in peripheral blood mononuclear cells (PBMC) and in liver-infiltrating lymph
Levels of IL-12 in the sera of patients with systemic lupus erythematosus (SLE)--relation to Th1- and Th2-derived cytokines.: Clin Exp Immunol. 1999 Apr;116(1):169-73. Unique Identifier : AIDSLINE MED/99225997; Tokano Y; Morimoto S; Kaneko H; Amano H; Nozawa K; Takasaki Y; Hashimoto H; Department of Rheumatology and Internal Medicine, Juntendo; University, School of Medicine, Tokyo, Japan.; IL-12 is a cytokine that induces Th1-derived cytokines (interferon-gamma (IFN-gamma) and IL-2 ). The significance of IL-12 in human autoimmunity is no clear, and the serum levels of IL-12 in SLE are not clearly established. Therefore, we examined the levels of IL-12 in
The effects of extracorporeal whole body hyperthermia on the functional and phenotypic features of canine peripheral blood mononuclear cells (PBMC).: Clin Exp Immunol. 1999 Apr;116(1):188-92. Unique Identifier : AIDSLINE MED/99226000; Kearns RJ; Ringler S; Krakowka S; Tallman R; Sites J; Oglesbee MJ; Department of Biology, University of Dayton, OH, USA.; In this study the effect of transient 42.3 degrees C whole body hyperthermia (WBH) on the distribution of PBMC phenotypes and in vitro blastogenic responsiveness was determined in dogs. Hyperthermia (n = 6) was induced by heating venous blood during extracorporeal circulation (venous perfusion WBH); perfused non-heate
Immunomodulation by vitamin B12: augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment.: Clin Exp Immunol. 1999 Apr;116(1):28-32. Unique Identifier : AIDSLINE MED/99225976; Tamura J; Kubota K; Murakami H; Sawamura M; Matsushima T; Tamura T; Saitoh T; Kurabayshi H; Naruse T; Third Department of Internal Medicine, Gunma University School of; Medicine, Maebashi, Japan.; It has been suggested that vitamin B12 (vit.B12) plays an important role in immune system regulation, but the details are still obscure. In order to examine the action of vit.B12 on cells of the human immune system, lymphocyte subpopulations and NK cell activity were evaluated in 11 patients with vit.B12 deficiency an
Acitretin and AIDS-related Reiter's disease.: Clin Exp Rheumatol. 1999 Jan-Feb;17(1):105-6. Unique Identifier : AIDSLINE MED/99183789; Blanche P; Service of Internal Medicine, Faculty of Medicine Rene; Descartes, Hopital Cochin, Paris, France.; A patient with AIDS presented with Reiter s syndrome. Arthritis and skin lesions responded poorly to nonsteroidal anti-inflammatory drugs and topical corticosteroid therapy. Dramatic improvement was seen 2 weeks after acitretine was added. When Reiter s syndrome recurred 11 months later despite treatment with highly a
Vasculitis and oral and genital ulcers: Behcet's syndrome or HIV infection? [letter]: Clin Exp Rheumatol. 1999 Jan-Feb;17(1):124. Unique Identifier : AIDSLINE MED/99183794; Olive A; Fuente MJ; Veny A; Romeu J
Clinical pharmacokinetics of lamivudine.: Clin Pharmacokinet. 1999 Jan;36(1):41-66. Unique Identifier : AIDSLINE MED/99143934; Johnson MA; Moore KH; Yuen GJ; Bye A; Pakes GE; Glaxo Wellcome Research and Development, Greenford, England.; maj@glaxowellcome.co.uk; Lamivudine ( 3TC ), the negative enantiomer of 2 -deoxy-3 -thiacytidine, is a dideoxynucleoside analogue used in combination with other agents in the treatment of human immunodeficiency
Performance of an algorithm to detect Pneumocystis carinii pneumonia in symptomatic HIV-infected persons. Pulmonary Complications of HIV Infection Study Group.: Chest. 1999 Apr;115(4):1025-32. Unique Identifier : AIDSLINE MED/99222885; Huang L; Stansell J; Osmond D; Turner J; Shafer KP; Fulkerson W; Kvale P; Wallace J; Rosen M; Glassroth J; Reichman L; Hopewell P; San Francisco General Hospital and University of California,; 94110, USA. lhuang@sfaids.ucsf.edu; STUDY OBJECTIVES: To determine whether an algorithm consisting of a chest radiograph and the diffusing capacity of the lung for carbon monoxide (D(LCO)) is effective in detecting Pneumocystis carinii pneumonia (PCP) in symptomatic HIV-infected persons; and to establish a benchmark for future comparisons of alternative
Mycobacterium avium-intracellulare pulmonary infection in HIV-negative patients without preexisting lung disease: diagnostic and management limitations.: Chest. 1999 Apr;115(4):1033-40. Unique Identifier : AIDSLINE MED/99222886; Huang JH; Kao PN; Adi V; Ruoss SJ; Pulmonary and Critical Care Medicine, Stanford University Medical; Center, CA 94305-5236, USA.; STUDY OBJECTIVES: To review the experience of an outpatient pulmonary clinic with Mycobacterium avium-intracellulare (MAI) pulmonary disease in the HIV-negative population without preexisting lung disease. DESIGN: Retrospective clinical series. SETTING: University medical center. PATIENTS: The clinic charts of all pat
Thoracic empyema in HIV-infected patients [letter]: Chest. 1999 Apr;115(4):1219-20. Unique Identifier : AIDSLINE MED/99222923; Riquet M; Hubsch JP; Chehab A
[HIV research: the interim report from Chicago (news)]: Dtsch Med Wochenschr. 1999 Mar 19;124(11):A7. Unique Identifier : AIDSLINE MED/99226001
[Riddle of HIV-1 origin solved (news)]: Dtsch Med Wochenschr. 1999 Mar 19;124(11):A7. Unique Identifier : AIDSLINE MED/99239723; Volkert R
[Intermittent therapy ought to strengthen the immune system (news)]: Dtsch Med Wochenschr. 1999 Mar 19;124(11):A8. Unique Identifier : AIDSLINE MED/99226003; Volkert R
[Latent infection in exposed high-risk persons (news)]: Dtsch Med Wochenschr. 1999 Mar 19;124(11):A8. Unique Identifier : AIDSLINE MED/99226004; Volkert R
[AIDS research benefits patients with hepatitis C (news)]: Dtsch Med Wochenschr. 1999 Mar 19;124(11):A9. Unique Identifier : AIDSLINE MED/99226005; Kowalski A
Effect of adding clofazimine to combined clarithromycin-ethambutol therapy for Mycobacterium avium complex septicemia in AIDS patients.: Eur J Clin Microbiol Infect Dis. 1999 Jan;18(1):16-22. Unique Identifier : AIDSLINE MED/99206927; Fournier S; Burguiere AM; Flahault A; Vincent V; Treilhou MP; Eliaszewicz M; Department of Infectious Diseases, Hopital Saint-Louis, Paris,; France.; This study compared the efficacies of clarithromycin-ethambutol and clarithromycin-ethambutol-clofazimine for the treatment of Mycobacterium avium complex (MAC) in AIDS patients. Thirty-four patients were randomized into two groups to receive clarithromycin 2 g/day and ethambutol 20 mg/kg/day, with or without clofazim
Human T-cell leukemia/lymphoma virus type II infection in Spain. HTLV Spanish Study Group.: Eur J Clin Microbiol Infect Dis. 1999 Jan;18(1):75-7. Unique Identifier : AIDSLINE MED/99206941; Soriano V; Machuca A; Gutierrez M; Service of Infectious Diseases, Instituto de Salud Carlos III,; Madrid, Spain. vsoriano@dragonet.es
Current approaches to diagnosis and treatment of fungal infections in children infected with human immuno deficiency virus.: Eur J Pediatr. 1999 Mar;158(3):187-99. Unique Identifier : AIDSLINE MED/99192259; Muller FM; Groll AH; Walsh TJ; Immunocompromised Host Section, Pediatric Oncology Branch,; National Cancer Institute, Bethesda, MD 20892, USA.; fmmueller@mail.uni-wuerzburg.de; The prolonged survival of profoundly immunocompromised patients has revealed mucosal and invasive fungal infections to be major causes of morbidity and mortality in advanced HIV disease in children of all age groups. Antifungal resistance has become a clinically relevant problem. Paediatricians caring for HIV-infected
Urolithiasis and the protease inhibitor indinavir.: Eur Urol. 1999;35(3):239-41. Unique Identifier : AIDSLINE MED/99172137; Hermieu J; Prevot M; Ravery V; Sauty L; Moulinier F; Delmas V; Bouvet E; Boccon-Gibod L; Department of Urology, Bichat Hospital, Paris, France.; OBJECTIVE: To evaluate specific urological abnormalities in patients treated with the protease inhibitor indinavir . METHODS: A series of 155 consecutive human immunodeficiency virus-positive patients were treated with indinavir 800 mg p.o. three times
Eukaryotic expression of enzymatically active human immunodeficiency virus type 1 reverse transcriptase.: FEBS Lett. 1999 Mar 26;447(2-3):232-6. Unique Identifier : AIDSLINE MED/99229765; Isaguliants MG; Pokrovskaya K; Kashuba VI; Pokholok D; Hinkula J; Wahren B; Kochetkov SN; D.I. Ivanovsky Institute of Virology, Moscow, Russia.; maria.isaguliants@solna.mail.telia.com; Reverse transcriptase of human immunodeficiency virus type I is a vitalenzyme in the HIV-1 replication cycle and an attractive target of attempts to arrest a primary viral infection. We designed a vector for eukaryotic expression of the 66 kDa subunit of reverse transcriptase under the control of the immediate early
Teaching safe sex in school.: Int J Gynaecol Obstet. 1998 Dec;63 Suppl 1:S147-50. Unique Identifier : AIDSLINE MED/99173547; Short R; Department Perinatal Medicine, Royal Women's Hospital, University; of Melbourne, Australia.; OBJECTIVE: To teach safe sex practices to adolescents in school, before they start to become sexually active, using peer group education. METHOD: To send young medical students back to their old schools to do the teaching, and to get them to make videos suitable for showing to teenage audiences that can be widely circ
HIV: mother to child transmission, current knowledge and on-going studies.: Int J Gynaecol Obstet. 1998 Dec;63 Suppl 1:S161-5. Unique Identifier : AIDSLINE MED/99173550; Giaquinto C; Ruga E; Giacomet V; Rampon O; D'Elia R; Dipartimento di Pediatria, Padova, Italy.; It is estimated that approximately 6000 women of childbearing age, mostly living in the developing world, acquire HIV infection every day. Taking into account that approximately 98% of HIV infected children have acquired HIV from the mother, during pregnancy, at delivery or through breastfeeding, therefore, prevention
Changing behavior to prevent STDs/AIDS.: Int J Gynaecol Obstet. 1998 Dec;63 Suppl 1:S175-81. Unique Identifier : AIDSLINE MED/99173552; Fishbein M; Public Policy Center, Annenberg School for Communication,; University of Pennsylvania, Philadelphia 19104, USA. mxf@cdc.gov; There is a growing body of evidence that theory-based behavioral interventions can effectively reduce risky behaviors that can lead to the acquisition and transmission of STDs/HIV. Despite the substantive uniqueness of any given behavior, there are only a limited number of theoretical variables that need to be conside
Current approach to STD management in women.: Int J Gynaecol Obstet. 1998 Dec;63 Suppl 1:S183-9. Unique Identifier : AIDSLINE MED/99173553; Amaral E; Department of Obstetrics and Gynecology, School of Medical; Sciences, State University of Campinas (UNICAMP), Brazil.; elianaa@obelix.unicamp.br; HIV infection was recognized as a new sexually transmitted disease (STD) at the beginning of the last decade. The knowledge of risk factors for sexual transmission of HIV changed the focus on STD to a broader perspective for prevention and control of HIV infection, and consequently of STD. Barriers to STD control incl
[Hypertriglyceridemia during active intercurrent infections in HIV-infected patients]: Gac Med Mex. 1999 Jan-Feb;135(1):5-9. Unique Identifier : AIDSLINE MED/99220508; Montero A; Albrecht AA; Isea A; Bartolomeo M; Schujman LE; Acebal SM; Mule EC; Hospital Intendente Carrasco, Rosario, Argentina.; amontero@sede.unr.edu.ar; BACKGROUND: Many reports have confirmed that hypertriglyceridemia (HTG) is more common in HIV-infected patients than in the general population, but the relationship between HTG and clinical conditions have not been well established. This work analyzes the relationships between CD4+ cell count, HTG and the presence of
[Long-term observation on children. HIV-positive pregnant women: AZT therapy to be continued]: Fortschr Med. 1999 Mar 20;117(8):6. Unique Identifier : AIDSLINE MED/99237298; Gurtler L
Moderate and high intensity exercise training in HIV-1 seropositive individuals: a randomized trial.: Unique Identifier : AIDSLINE MED/99205052; Terry L; Sprinz E; Ribeiro JP; HIV-infected individuals are frequently active, but guidelines for exercise in this population lack scientific support, since studies on the effects of exercise training on immunologic variables of HIV-1 positive individuals have shown conflicting results. Exercise capacity, immunologic markers (CD4, CD8 and CD4:CD8 r
The significance of pretreatment CD4 count on the outcome and treatment tolerance of HIV-positive patients with anal cancer.: Int J Radiat Oncol Biol Phys. 1999 Apr 1;44(1):127-31. Unique Identifier : AIDSLINE MED/99235211; Hoffman R; Welton ML; Klencke B; Weinberg V; Krieg R; Department of Radiation Oncology, University of California, San; Francisco 94143-0226, USA.; PURPOSE: To assess the outcome and tolerance of HIV-positive patients with anal cancer to standard therapy based on their pretreatment CD4 count. METHODS AND MATERIALS: Between 1991 and 1997, 17 HIV-positive patients with anal cancer and documented pretreatment CD4 counts were treated at the University of California,
Effect of a single bout of acute exercise on plasma human immunodeficiency virus RNA levels.: J Appl Physiol. 1999 Apr;86(4):1197-201. Unique Identifier : AIDSLINE MED/99210307; Roubenoff R; Skolnik PR; Shevitz A; Snydman L; Wang A; Melanson S; Gorbach S; Department of Community Health, Department of Medicine, Tufts; University School of Medicine, Boston 02111, Boston,; Massachusetts 02111, USA. roubenoff@hnrc.tufts.edu; Acute exercise is known to activate the immune system and thus could lead to increased human immunodeficiency virus (HIV) replication. We sought to determine whether a single acute bout of exercise, similar to what people experience when starting an intensive exercise program, has a detrimental effect on plasma HIV RN
Antidepressant efficacy in HIV-seropositive outpatients with major depressive disorder: an open trial of nefazodone.: J Clin Psychiatry. 1999 Apr;60(4):226-31. Unique Identifier : AIDSLINE MED/99236471; Elliott AJ; Russo J; Bergam K; Claypoole K; Uldall KK; Roy-Byrne PP; Department of Psychiatry and Behavior Sciences, University of; Washington, and the Madison Clinic at Harborview Medical Center,; Seattle 98104, USA. aelliott@u.washington.edu; BACKGROUND: Treatment studies of major depression in patients who are seropositive for the human immunodeficiency virus (HIV) have shown comparable efficacy for both tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs). Nefazodone appears to be more tolerable than TCAs and similar to SS
Molecular uncoupling of fractalkine-mediated cell adhesion and signal transduction. Rapid flow arrest of CX3CR1-expressing cells is independent of G-protein activation.: J Biol Chem. 1999 Apr 9;274(15):10053-8. Unique Identifier : AIDSLINE MED/99214559; Haskell CA; Cleary MD; Charo IF; Gladstone Institute of Cardiovascular Disease, San Francisco, CA; 94141-9100, USA.; Fractalkine is a novel multidomain protein expressed on the surface of activated endothelial cells. Cells expressing the chemokine receptor CX3CR1 adhere to fractalkine with high affinity, but it is not known if adherence requires G-protein activation and signal transduction. To investigate the cell adhesion propertie
Cell surface retention sequence binding protein-1 interacts with the v-sis gene product and platelet-derived growth factor beta-type receptor in simian sarcoma virus-transformed cells.: J Biol Chem. 1999 Apr 9;274(15):10582-9. Unique Identifier : AIDSLINE MED/99214628; Boensch C; Huang SS; Connolly DT; Huang JS; Department of Biochemistry and Molecular Biology, St. Louis; University School of Medicine, St. Louis, Missouri 63104, USA.; The cell surface retention sequence (CRS) binding protein-1 (CRSBP-1) is a newly identified membrane glycoprotein which is hypothesized to be responsible for cell surface retention of the oncogene v-sis and c-sis gene products and other secretory proteins containing CRSs. In simian sarcoma virus-transformed NIH 3T3 ce
Early assembly step of a retroviral envelope glycoprotein: analysis using a dominant negative assay.: J Cell Biol. 1999 Apr 5;145(1):57-68. Unique Identifier : AIDSLINE MED/99207051; Rosenberg AR; Delamarre L; Pique C; Le Blanc I; Griffith G; Dokhelar MC; Institut National de la Sante et de la Recherche Medicale U332,; Institut Cochin de Genetique Moleculaire, 75014 Paris, France.; arielle@cochin.inserm.fr; As for most integral membrane proteins, the intracellular transport of retroviral envelope glycoproteins depends on proper folding and oligomeric assembly in the ER. In this study, we considered the hypothesis that a panel of 22 transport-defective mutants of the human T cell leukemia virus type 1 envelope glycoprotei
Upper body lipomas in an HIV-infected man.: Hosp Pract (Off Ed). 1999 Apr 15;34(4):130, 135. Unique Identifier : AIDSLINE MED/99229107; Meza AD; Verghese A; Division of Infectious Diseases, Texas Tech University Health; Sciences Center School of Medicine, El Paso, USA.
Board specialty and treatment of HIV infection [letter]: Hosp Pract (Off Ed). 1999 Apr 15;34(4):62. Unique Identifier : AIDSLINE MED/99243915; Dodge WT
Pharmacokinetics of trimetrexate and dapsone in AIDS patients with Pneumocystis carinii pneumonia.: J Clin Pharmacol. 1999 Mar;39(3):268-74. Unique Identifier : AIDSLINE MED/99172981; Koda RT; Dube MP; Li WY; Chatterjee DJ; Stansell JD; Sattler FR; School of Pharmacy, University of Southern California, Los; Angeles 90033, USA.; The objective of this study was to determine the pharmacokinetics of trimetrexate and dapsone in AIDS patients with moderate to severe pneumocystis pneumonia. Trimetrexate, leucovorin, and dapsone were administered for 21 +/- 3 days in the following doses: trimetrexate glucuronate, 45 mg/m2; leucovorin, 20 mg/m2; and
Exposure of medical students to body fluids.: J Am Coll Health. 1999 Mar;47(5):207-10. Unique Identifier : AIDSLINE MED/99226399; Ganguly R; Holt DA; Sinnott JT; Department of Internal Medicine, University of South Florida,; Tampa, USA.; Three hundred forty-two students at 3 Florida medical schools were surveyed concerning occupational exposures to blood and body fluids during their 3rd-year clerkship. The 16-item questionnaire was anonymously returned by 150 students, and differences among groups were assessed at p
Is Streptococcus pneumoniae a nosocomially acquired pathogen?: Infect Control Hosp Epidemiol. 1998 Aug;19(8):578-80. Unique Identifier : AIDSLINE MED/98429026; Paradisi F; Corti G; Infectious Disease Unit, University of Florence School of; Medicine, Italy. infdis@cesit1.unifi.it; Streptococcus pneumoniae is most prominently a major cause of community-acquired infections of the respiratory tract, central nervous system, and bloodstream, but there is an increasing interest in its role in the epidemiology of hospital-acquired infections. Penicillin-resistant pneumococcal strains appeared 3 decade
Cutting edge: sustained expansion of CD8+ T cells requires CD154 expression by Th cells in acute graft versus host disease.: J Immunol. 1999 Apr 15;162(8):4373-6. Unique Identifier : AIDSLINE MED/99218468; Buhlmann JE; Gonzalez M; Ginther B; Panoskaltsis-Mortari A; Blazar BR; Greiner DL; Rossini AA; Flavell R; Noelle RJ; Department of Microbiology, Dartmouth Medical School, Lebanon, NH; 03756, USA.; Brief treatment with alphaCD154 Ab has been shown to prevent acute graft versus host disease (aGvHD). We extend these data to show that in the absence of CD154 function, donor T cells are unable to expand or generate high level anti-host CTL activity. Using transgenic (Tg) alloreactive CD8+ T cells adoptively transfer
Virus-induced CD8+ T cell clonal expansion is associated with telomerase up-regulation and telomere length preservation: a mechanism for rescue from replicative senescence.: J Immunol. 1999 Apr 15;162(8):4521-6. Unique Identifier : AIDSLINE MED/99218488; Maini MK; Soares MV; Zilch CF; Akbar AN; Beverley PC; Imperial Cancer Research Fund Tumour Immunology Unit, Department; of Oncology, University College London Medical School, United; Kingdom.; In acute infectious mononucleosis (AIM), very large clones of Ag-specific CD8+ effector T cells are generated. Many clones persist as memory cells, although the clone size is greatly reduced. It would be expected that the large number of cell divisions occurring during clonal expansion would lead to shortening of telo
Pancreatic infiltration but not diabetes occurs in the relative absence of MHC class II-restricted CD4 T cells: studies using NOD/CIITA-deficient mice.: J Immunol. 1999 Apr 15;162(8):4576-88. Unique Identifier : AIDSLINE MED/99218495; Mora C; Wong FS; Chang CH; Flavell RA; Section of Immunobiology, Yale University School of Medicine,; Howard Hughes Medical Institute, New Haven, CT 06520, USA.; The NOD (nonobese diabetic) mouse is a good animal model for human IDDM. MHC class II-restricted CD4 T cells are necessary for the onset of diabetes in NOD mice. Here, we demonstrate that NOD mice lacking the CIITA (class II transactivator) molecule, and hence deficient in MHC class II expression and peripheral CD4 T
TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes.: Unique Identifier : AIDSLINE MED/99218497; Kagi D; Ho A; Odermatt B; Zakarian A; Ohashi PS; Mak TW; Ontario Cancer Institute/Amgen Institute, Toronto, Canada.; dkagi@amgen.com; Autoimmune diabetes is characterized by a chronic progressive inflammatory autoimmune reaction that ultimately causes the selective elimination of pancreatic beta cells. To address the question of whether the cell death-inducing cytokines TNF and lymphotoxin alpha are involved in this process, we generated nonobese di
Type 1 and type 2 cytokine regulation of macrophage endocytosis: differential activation by IL-4/IL-13 as opposed to IFN-gamma or IL-10.: J Immunol. 1999 Apr 15;162(8):4606-13. Unique Identifier : AIDSLINE MED/99218498; Montaner LJ; da Silva RP; Sun J; Sutterwala S; Hollinshead M; Vaux D; Gordon S; The Wistar Institute, Philadelphia, PA 19104, USA.; montaner@wistar.upenn.edu; Cytokine regulation of endocytic activity in primary human macrophages was studied to define ultrastructural changes and mechanisms of pinocytic regulation associated with cytokines secreted by activated T cells. The effects of IFN-gamma (type 1) and IL-4/IL-13 and IL-10 (type 2) cytokines on fluid phase and mannose r
Two mechanisms for the non-MHC-linked resistance to spontaneous autoimmunity.: J Immunol. 1999 Apr 15;162(8):4614-26. Unique Identifier : AIDSLINE MED/99218499; Verdaguer J; Amrani A; Anderson B; Schmidt D; Santamaria P; Department of Microbiology and Infectious Diseases, Julia; McFarlane Diabetes Research Centre, Faculty of Medicine,; University of Calgary, Alberta, Canada.; Genetic susceptibility and resistance to most autoimmune disorders are associated with highly polymorphic genes of the MHC and with non-MHC-linked polygenic modifiers. It is known that non-MHC-linked polymorphisms can override or enhance the susceptibility to an autoimmune disease provided by pathogenic MHC genes, but
Dramatic influence of V beta gene polymorphism on an antigen-specific CD8+ T cell response in vivo.: J Immunol. 1999 Apr 15;162(8):4647-56. Unique Identifier : AIDSLINE MED/99218502; Bour H; Michielin O; Bousso P; Cerottini JC; MacDonald HR; Ludwig Institute for Cancer Research, Lausanne Branch, University; of Lausanne, Epalinges, Switzerland.; According to recent crystallographic studies, the TCR-alpha beta contacts MHC class I-bound antigenic peptides via the polymorphic V gene-encoded complementarity-determining region 1 beta (CDR1 beta) and the hypervariable (D)J-encoded CDR3 beta and CDR3 alpha domains. To evaluate directly the relative importance of CD
Enhancement of the Listeria monocytogenes p60-specific CD4 and CD8 T cell memory by nonpathogenic Listeria innocua.: J Immunol. 1999 Apr 15;162(8):4781-9. Unique Identifier : AIDSLINE MED/99218518; Geginat G; Nichterlein T; Kretschmar M; Schenk S; Hof H; Lalic-Multhaler M; Goebel W; Bubert A; Institut fur Medizinische Mikrobiologie und Hygiene, Fakultat; fur Klinische Medizin Mannheim der Universitat Heidelberg,; Mannheim, Germany. geginat@rumms.uni-mannheim.de; The contact of T cells to cross-reactive antigenic determinants expressed by nonpathogenic environmental micro-organisms may contribute to the induction or maintenance of T cell memory. This hypothesis was evaluated in the model of murine Listeria monocytogenes infection. The influence of nonpathogenic L. innocua on t
Persistent HIV-1-specific CTL clonal expansion despite high viral burden post in utero HIV-1 infection.: J Immunol. 1999 Apr 15;162(8):4796-800. Unique Identifier : AIDSLINE MED/99218520; Brander C; Goulder PJ; Luzuriaga K; Yang OO; Hartman KE; Jones NG; Walker BD; Kalams SA; AIDS Research Center and Infectious Disease Unit, Massachusetts; General Hospital, Harvard Medical School, Charlestown, MA 02129,; USA.; To address the issue of clonal exhaustion in humans, we monitored HLA class I-restricted, epitope-specific CTL responses in an in utero HIV-1-infected infant from 3 mo through 5 years of age. Serial functional CTL precursor assays demonstrated persistent, vigorous, and broadly directed HIV-1 specific CTL activity with
Host B7-1 and B7-2 costimulatory molecules contribute to the eradication of B7-1-transfected P815 tumor cells via a CD8+ T cell-dependent mechanism.: J Immunol. 1999 Apr 15;162(8):4817-23. Unique Identifier : AIDSLINE MED/99218523; La Motte RN; Sharpe AH; Bluestone JA; Mokyr MB; Department of Biochemistry and Molecular Biology, University of; Illinois, Chicago 60612, USA.; B7-1 (CD80)-transfected P815 tumor cells were previously shown to elicit tumor-eradicating immunity that leads to the regression of B7-1+ P815 tumors after transient growth in normal syngeneic (DBA/2) mice. Here, we show that not only the B7-1 molecule but also the B7-2 (CD86) molecule contributed to the eradication o
CD26/dipeptidyl-peptidase IV down-regulates the eosinophil chemotactic potency, but not the anti-HIV activity of human eotaxin by affecting its interaction with CC chemokine receptor 3.: J Immunol. 1999 Apr 15;162(8):4903-9. Unique Identifier : AIDSLINE MED/99218533; Struyf S; Proost P; Schols D; De Clercq E; Opdenakker G; Lenaerts JP; Detheux M; Parmentier M; De Meester I; Scharpe S; Van Damme J; Laboratory of Molecular Immunology, Rega Institute for Medical; Research, University of Leuven, Belgium.; Chemokines attract and activate distinct sets of leukocytes. The CC chemokine eotaxin has been characterized as an important mediator in allergic reactions because it selectively attracts eosinophils, Th2 lymphocytes, and basophils. Human eotaxin has a penultimate proline, indicating that it might be a substrate for d
A circulating bovine gamma delta T cell subset, which is found in large numbers in the spleen, accumulates inefficiently in an artificial site of inflammation: correlation with lack of expression of E-selectin ligands and L-selectin.: J Immunol. 1999 Apr 15;162(8):4914-9. Unique Identifier : AIDSLINE MED/99218535; Wilson E; Aydintug MK; Jutila MA; Department of Veterinary Molecular Biology, Montana State; University, Bozeman 59717, USA.; Tissue-specific localization of TCR-defined subsets of gamma delta T cells has been widely reported; however, the mechanisms responsible for this phenomenon are poorly understood. We describe a bovine gamma delta T cell TCR-associated subset that preferentially localizes in the spleen. This subset was characterized by
Administration of mAb against alpha E beta 7 prevents and ameliorates immunization-induced colitis in IL-2-/- mice.: J Immunol. 1999 Apr 15;162(8):4975-82. Unique Identifier : AIDSLINE MED/99218543; Ludviksson BR; Strober W; Nishikomori R; Hasan SK; Ehrhardt RO; Mucosal Immunity Section, Laboratory of Clinical Investigation,; National Institute of Allergy and Infectious Diseases, Bethesda,; MD 20892, USA. bludviksso@atlas.niaid.nih.gov; We previously demonstrated that 2,4,6-trinitrophenol (TNP)-OVA immunization leads to a transmural colitis in the IL-2-/- mouse that is caused by IL-12-driven CD4+ Th1 T cells and resembles human Crohn s disease. The integrin alpha E beta 7 is highly expressed on colonic intraepithelial lymphocytes and has been suggest
Non-Hodgkin's lymphoma of the lacrimal sac and concomitant pansinusitis.: J Laryngol Otol. 1998 Oct;112(10):969-70. Unique Identifier : AIDSLINE MED/99227670; el-Hakim H; Nunez DA; Department of Otolaryngology, Aberdeen Royal Infirmary, UK.; Paranasal sinus disease has an established propensity to breach anatomical barriers and present with orbital clinical features. Lacrimal sac lymphomas on the other hand are rare, usually present in males in the sixth decade and 50 per cent of cases have systemic lymphoma/leukaemia. Atypical presentations of lymphomas
Non-Hodgkin's lymphoma of the maxillary sinus in a patient with acquired immunodeficiency syndrome.: J Laryngol Otol. 1998 Oct;112(10):982-5. Unique Identifier : AIDSLINE MED/99227675; Del Forno A; Del Borgo C; Turriziani A; Ottaviani F; Antinori A; Fantoni M; Department of Infectious Diseases, Catholic University, Rome,; Italy.; Non-Hodgkin s lymphoma (NHL) is one of the most common malignancies in patients infected with human immunodeficiency virus (HIV): it occurs 25-60 times more frequently in HIV-infected patients than in the general population. This neoplasm in acquired immunodeficiency syndrome (AIDS) patients is a highly aggressive tum
Spontaneous regression of primary autoreactivity during chronic progression of experimental autoimmune encephalomyelitis and multiple sclerosis [see comments]: J Exp Med. 1999 Apr 5;189(7):1033-42. Unique Identifier : AIDSLINE MED/99207065; Tuohy VK; Yu M; Yin L; Kawczak JA; Kinkel RP; Department of Immunology, Lerner Research Institute, The; Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.; tuohyv@cesmtp.ccf.org; Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for multiple sclerosis (MS). EAE is typically initiated by CD4(+) T helper cell type 1 (Th1) autoreactivity directed against a single priming immunodominant myelin peptide determinant. Recent studies have shown that clinical progression of E
Fas gene mutation in the progression of adult T cell leukemia.: J Exp Med. 1999 Apr 5;189(7):1063-71. Unique Identifier : AIDSLINE MED/99207068; Maeda T; Yamada Y; Moriuchi R; Sugahara K; Tsuruda K; Joh T; Atogami S; Tsukasaki K; Tomonaga M; Kamihira S; Department of Hematology and Molecular Medicine Unit, Atomic Bomb; Disease Institute, Aichi 464-0221, Japan.; tmaeda@net.nagasaki-u.ac.jp; Fas antigen (Apo-1/CD95) is an apoptosis-signaling cell surface receptor belonging to the tumor necrosis factor receptor superfamily. Adult T cell leukemia (ATL) cells express Fas antigen and show apoptosis after treatment with an anti-Fas monoclonal antibody. We established the ATL cell line KOB, which showed resista
Bone marrow NK1.1(-) and NK1.1(+) T cells reciprocally regulate acute graft versus host disease.: J Exp Med. 1999 Apr 5;189(7):1073-81. Unique Identifier : AIDSLINE MED/99207069; Zeng D; Lewis D; Dejbakhsh-Jones S; Lan F; Garcia-Ojeda M; Sibley R; Strober S; Department of Medicine, Division of Immunology and Rheumatology,; Stanford, California 94305, USA.; Sorted CD4(+) and CD8(+) T cells from the peripheral blood or bone marrow of donor C57BL/6 (H-2(b)) mice were tested for their capacity to induce graft-versus-host disease (GVHD) by injecting the cells, along with stringently T cell-depleted donor marrow cells, into lethally irradiated BALB/c (H-2(d)) host mice. The p
Effector cells of both nonhemopoietic and hemopoietic origin are required for interferon (IFN)-gamma- and tumor necrosis factor (TNF)-alpha-dependent host resistance to the intracellular pathogen, Toxoplasma gondii.: J Exp Med. 1999 Apr 5;189(7):1083-92. Unique Identifier : AIDSLINE MED/99207070; Yap GS; Sher A; Immunobiology Section, Laboratory of Parasitic Diseases, National; Institutes of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, Maryland 20892, USA.; gyap@atlas.niaid.nih.gov; Although interferon (IFN)-gamma-activated, mononuclear phagocytes are considered to be the major effectors of resistance to intracellular pathogens, it is unclear how they control the growth of microorganisms that reside in nonhemopoietic cells. Pathogens within such cells may be killed by metabolites secreted by acti
Altered ligands reveal limited plasticity in the T cell response to a pathogenic epitope.: J Exp Med. 1999 Apr 5;189(7):1111-20. Unique Identifier : AIDSLINE MED/99207073; Pingel S; Launois P; Fowell DJ; Turck CW; Southwood S; Sette A; Glaichenhaus N; Louis JA; Locksley RM; Departments of Medicine, Microbiology, and Immunology, University; of California San Francisco, San Francisco, California 94143,; USA.; Experimental leishmaniasis offers a well characterized model of T helper type 1 cell (Th1)-mediated control of infection by an intracellular organism. Susceptible BALB/c mice aberrantly develop Th2 cells in response to infection and are unable to control parasite dissemination. The early CD4(+) T cell response in thes
Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice.: J Exp Med. 1999 Apr 5;189(7):1129-38. Unique Identifier : AIDSLINE MED/99207075; Kanakaraj P; Ngo K; Wu Y; Angulo A; Ghazal P; Harris CA; Siekierka JJ; Peterson PA; Fung-Leung WP; R.W. Johnson Pharmaceutical Research Institute, San Diego,; California 92121, USA.; Interleukin (IL)-18 is functionally similar to IL-12 in mediating T helper cell type 1 (Th1) response and natural killer (NK) cell activity but is related to IL-1 in protein structure and signaling, including recruitment of IL-1 receptor-associated kinase (IRAK) to the receptor and activation of c-Jun NH2-terminal kin
Understanding HIV-related risk among persons with a severe and persistent mental illness: insights from qualitative inquiry.: J Nerv Ment Dis. 1999 Apr;187(4):208-16. Unique Identifier : AIDSLINE MED/99236742; Gordon CM; Carey MP; Carey KB; Maisto SA; Weinhardt LS; Department of Psychology, Syracuse University, New York; 13244-2340, USA.; We conducted focus groups with 36 men and women who were receiving treatment for a severe and persistent mental illness (SPMI) to learn more about the social context of their intimate relationships and the psychological antecedents of their sexual decision-making. Qualitative analysis of focus group transcripts indica
Antisense and nuclear medicine.: J Nucl Med. 1999 Apr;40(4):693-703. Unique Identifier : AIDSLINE MED/99224937; Hnatowich DJ; Department of Nuclear Medicine, University of Massachusetts; Medical Center, Worcester 01655, USA.; Despite many uncertainties concerning mechanism, synthetic single-strand antisense deoxyribonucleic acids (DNAs) are now in clinical trials for the chemotherapy of viral infections such as human immunodeficiency virus (HIV) and human papilloma virus; several cancers, including follicular lymphoma and acute myelogenous
Periodontal immune responses of human lymphocytes in Actinobacillus actinomycetemcomitans-inoculated NOD/SCID mice engrafted with peripheral blood leukocytes of periodontitis patients.: J Periodontal Res. 1999 Jan;34(1):54-61. Unique Identifier : AIDSLINE MED/99184691; Teng YT; Nguyen H; Hassanloo A; Ellen RP; Hozumi N; Gorczynski RM; Department of Microbiology and Immunology, Faculty of Medicine; and Dentistry, the University of Western Ontario, London, Canada.; yateng@julian.uwo.ca
Characterization of antigens expressed in normal baboon trophoblast and cross-reactive with HIV/SIV antibodies.: Unique Identifier : AIDSLINE MED/99196467; Langat DK; Johnson PM; Rote NS; Wango EO; Owiti GO; Isahakia MA; Mwenda JM; Institute of Primate Research, Karen, Nairobi, Kenya.; Electron microscopic studies have revealed the presence of endogenous retroviral (ERV) particles in normal primate placental tissues. These particles have ultrastructural similarities to type C retroviral particles and are mainly associated with the trophoblast. In normal human placental tissues, they have antigenic s
Venom anyone? Researchers tweak "bad" compounds into good medicines [news]: J Natl Cancer Inst. 1999 Apr 21;91(8):667-8. Unique Identifier : AIDSLINE MED/99232869; Volkers N
Human immunodeficiency virus infection in Haiti.: Unique Identifier : AIDSLINE MED/99220120; Pierre JA; Fournier AM; This article reviews human immunodeficiency virus (HIV) infection in Haiti . The evolution of the epidemic in Haiti, its spread from
Effect of mutations in the second extracellular loop of CXCR4 on its utilization by human and feline immunodeficiency viruses.: J Virol. 1999 Apr;73(4):2576-86. Unique Identifier : AIDSLINE MED/99173949; Brelot A; Heveker N; Adema K; Hosie MJ; Willett B; Alizon M; INSERM U.332, Institut Cochin de Genetique Moleculaire, 75014; Paris, France.; CCR5 and CXCR4 are the principal CD4-associated coreceptors used by human immunodeficiency virus type 1 (HIV-1). CXCR4 is also a receptor for the feline immunodeficiency virus (FIV). The rat CXCR4 cannot mediate infection by HIV-1NDK or by FIVPET (both cell line-adapted strains) because of sequence differences with hu
Differential cell tropism of feline immunodeficiency virus molecular clones in vivo.: J Virol. 1999 Apr;73(4):2596-603. Unique Identifier : AIDSLINE MED/99173951; Dean GA; Himathongkham S; Sparger EE; Department of Microbiology, Pathology, and Parasitology, College; of Veterinary Medicine, North Carolina State University, Raleigh,; North Carolina 27606, USA.; Independent studies have demonstrated different cell tropisms for molecular clones of feline immunodeficiency virus (FIV). In this report, we examined three clones, FIV-pF34, FIV-14, and FIV-pPPR, for replication in Crandell feline kidney (CrFK) cells, feline peripheral blood mononuclear cells (PBMC), and feline macro
Opposing effects of human immunodeficiency virus type 1 matrix mutations support a myristyl switch model of gag membrane targeting.: J Virol. 1999 Apr;73(4):2604-12. Unique Identifier : AIDSLINE MED/99173952; Paillart JC; Gottlinger HG; Department of Cancer Immunology and AIDS, Dana-Farber Cancer; Institute, Harvard Medical School, Boston, Massachusetts 02115,; USA. Heinrich_Gottlinger@DFCI.harvard.edu; Targeting of the human immunodeficiency virus type 1 (HIV-1) Gag precursor Pr55(gag) to the plasma membrane, the site of virus assembly, is primarily mediated by the N-terminal matrix (MA) domain. N-myristylation of MA is essential for the stable association of Pr55(gag) with membranes and for virus assembly. We now s
Vif and the p55(Gag) polyprotein of human immunodeficiency virus type 1 are present in colocalizing membrane-free cytoplasmic complexes.: J Virol. 1999 Apr;73(4):2667-74. Unique Identifier : AIDSLINE MED/99173959; Simon JH; Carpenter EA; Fouchier RA; Malim MH; Departments of Microbiology, University of Pennsylvania School of; Medicine, Philadelphia, Pennsylvania 19104-6148, USA.; The Vif protein of human immunodeficiency virus type 1 (HIV-1) is a potent regulator of viral infectivity. Current data posit that Vif functions late in replication to modulate assembly, budding, and/or maturation. Consistent with this model, earlier indirect immunofluorescence analyses of HIV-1-infected cells demonst
Mutational analysis of the human immunodeficiency virus type 1 Vif protein.: J Virol. 1999 Apr;73(4):2675-81. Unique Identifier : AIDSLINE MED/99173960; Simon JH; Sheehy AM; Carpenter EA; Fouchier RA; Malim MH; Departments of Microbiology, University of Pennsylvania School of; Medicine, Philadelphia, Pennsylvania 19104-6148, USA.; Lentivirus Vif proteins are potent regulators of virus infectivity. However, relatively little is known about the functional domains, peptide motifs, or residues of any Vif protein. In this report, we present the first extensive mutagenesis analysis of the 192-amino-acid human immunodeficiency virus type 1 (HIV-1) Vif
Drastic fitness loss in human immunodeficiency virus type 1 upon serial bottleneck events.: J Virol. 1999 Apr;73(4):2745-51. Unique Identifier : AIDSLINE MED/99173968; Yuste E; Sanchez-Palomino S; Casado C; Domingo E; Lopez-Galindez C; Centro Nacional de Biologia Fundamental, Instituto de Salud; Carlos III, Majadahonda, 28220 Madrid, Spain.; Muller s ratchet predicts fitness losses in small populations of asexual organisms because of the irreversible accumulation of deleterious mutations and genetic drift. This effect should be enhanced if population bottlenecks intervene and fixation of mutations is not compensated by recombination. To study whether Mull
Identification of CXCR4 domains that support coreceptor and chemokine receptor functions.: J Virol. 1999 Apr;73(4):2752-61. Unique Identifier : AIDSLINE MED/99173969; Doranz BJ; Orsini MJ; Turner JD; Hoffman TL; Berson JF; Hoxie JA; Peiper SC; Brass LF; Doms RW; Department of Pathology and Laboratory Medicine, Department of; Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; 19104, USA.; The interaction of the chemokine stromal cell-derived factor 1 (SDF-1) with its receptor CXCR4 is vital for cell trafficking during development, is capable of inhibiting human immunodeficiency virus type 1 (HIV-1) utilization of CXCR4 as a coreceptor, and has been implicated in delaying disease progression to AIDS in
Detection and induction of equine infectious anemia virus-specific cytotoxic T-lymphocyte responses by use of recombinant retroviral vectors.: J Virol. 1999 Apr;73(4):2762-9. Unique Identifier : AIDSLINE MED/99173970; Lonning SM; Zhang W; Leib SR; McGuire TC; Department of Veterinary Microbiology and Pathology, Washington; State University, Pullman, Washington 99164, USA.; Cytotoxic T lymphocytes (CTL) appear to be critical in resolving or reducing the severity of lentivirus infections. Retroviral vectors expressing the Gag/Pr or SU protein of the lentivirus equine infectious anemia virus (EIAV) were constructed and used to evaluate EIAV-specific CTL responses in horses. Three promoters
A second-site mutation that restores replication of a Tat-defective human immunodeficiency virus.: J Virol. 1999 Apr;73(4):2781-9. Unique Identifier : AIDSLINE MED/99173972; Verhoef K; Berkhout B; Department of Human Retrovirology, Academic Medical Center,; University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.; We previously constructed a large set of mutants of the human immunodeficiency virus type 1 (HIV-1) regulatory protein Tat with conservative amino acid substitutions in the activation domain. These Tat variants were analyzed in the context of the infectious virus, and several mutants were found to be defective for rep
Effect of the attenuating deletion and of sequence alterations evolving in vivo on simian immunodeficiency virus C8-Nef function.: J Virol. 1999 Apr;73(4):2790-7. Unique Identifier : AIDSLINE MED/99173973; Carl S; Iafrate AJ; Skowronski J; Stahl-Hennig C; Kirchhoff F; Institute for Clinical and Molecular Virology, University of; Erlangen-Nuernberg, 91054 Erlangen, Germany.; The simian immunodeficiency virus macC8 (SIVmacC8) variant has been used in a European Community Concerted Action project to study the efficacy and safety of live attenuated SIV vaccines in a large number of macaques. The attenuating deletion in the SIVmacC8 nef-long terminal repeat region encompasses only 12 bp and i
Lentivirus vectors using human and simian immunodeficiency virus elements.: J Virol. 1999 Apr;73(4):2832-40. Unique Identifier : AIDSLINE MED/99173978; White SM; Renda M; Nam NY; Klimatcheva E; Zhu Y; Fisk J; Halterman M; Rimel BJ; Federoff H; Pandya S; Rosenblatt JD; Planelles V; Departments of Medicine, University of Rochester Cancer Center,; Rochester, New York 14642, USA.; Lentivirus vectors based on human immunodeficiency virus (HIV) type 1 (HIV-1) constitute a recent development in the field of gene therapy. A key property of HIV-1-derived vectors is their ability to infect nondividing cells. Although high-titer HIV-1-derived vectors have been produced, concerns regarding safety still
Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors.: J Virol. 1999 Apr;73(4):2886-92. Unique Identifier : AIDSLINE MED/99173983; Zufferey R; Donello JE; Trono D; Hope TJ; Department of Genetics and Microbiology, University of Geneva; Medical School, CH-120 Geneva, Switzerland.; The expression of genes delivered by retroviral vectors is often inefficient, a potential obstacle for their widespread use in human gene therapy. Here, we explored the possibility that the posttranscriptional regulatory element of woodchuck hepatitis virus (WPRE) might help resolve this problem. Insertion of the WPRE
Interaction of the human immunodeficiency virus type 1 nucleocapsid with actin.: J Virol. 1999 Apr;73(4):2901-8. Unique Identifier : AIDSLINE MED/99173985; Liu B; Dai R; Tian CJ; Dawson L; Gorelick R; Yu XF; Department of Molecular Microbiology and Immunology, Johns; Hopkins University School of Hygiene and Public Health,; Baltimore, Maryland 21205, USA.; The nucleocapsid (NC) domain of the retrovirus Gag protein plays several important roles in the viral life cycle, including virus assembly, viral genomic RNA encapsidation, primer tRNA placement, and enhancement of viral reverse transcription. In this study, deletion of NC domain of human immunodeficiency virus type 1
Gibbon ape leukemia virus receptor functions of type III phosphate transporters from CHOK1 cells are disrupted by two distinct mechanisms.: J Virol. 1999 Apr;73(4):2916-20. Unique Identifier : AIDSLINE MED/99173987; Chaudry GJ; Farrell KB; Ting YT; Schmitz C; S Lie Y; Petropoulos CJ; Eiden MV; Laboratory of Cellular and Molecular Regulation, National; Institute of Mental Health, National Institutes of Health,; Bethesda, Maryland 20892, USA.; The Chinese hamster cell lines E36 and CHOK1 dramatically differ in susceptibility to amphotropic murine leukemia virus (A-MuLV) and gibbon ape leukemia virus (GALV); E36 cells are highly susceptible to both viruses, CHOK1 cells are not. We have previously shown that GALV can infect E36 cells by using both its own rec
Early short-term 9-[2-(R)-(phosphonomethoxy)propyl]adenine treatment favorably alters the subsequent disease course in simian immunodeficiency virus-infected newborn Rhesus macaques.: J Virol. 1999 Apr;73(4):2947-55. Unique Identifier : AIDSLINE MED/99173991; van Rompay KK; Dailey PJ; Tarara RP; Canfield DR; Aguirre NL; Cherrington JM; Lamy PD; Bischofberger N; Pedersen NC; Marthas ML; California Regional Primate Research Center, University of; California, Davis, California 95616, USA.; Simian immunodeficiency virus (SIV) infection of newborn macaques is a useful animal model of human pediatric AIDS to study disease pathogenesis and to develop intervention strategies aimed at delaying disease. In the present study, we demonstrate that very early events of infection greatly determine the ultimate dise
HMG protein family members stimulate human immunodeficiency virus type 1 and avian sarcoma virus concerted DNA integration in vitro.: J Virol. 1999 Apr;73(4):2994-3003. Unique Identifier : AIDSLINE MED/99173996; Hindmarsh P; Ridky T; Reeves R; Andrake M; Skalka AM; Leis J; Department of Biochemistry, Case Western Reserve University; School of Medicine, Cleveland, Ohio 44106-4935, USA.; We have reconstituted concerted human immunodeficiency virus type 1 (HIV-1) integration in vitro with specially designed mini-donor HIV-1 DNA, a supercoiled plasmid acceptor, purified bacterium-derived HIV-1 integrase (IN), and host HMG protein family members. This system is comparable to one previously described for
Human immunodeficiency virus types 1 and 2 differ in the predominant mechanism used for selection of genomic RNA for encapsidation.: J Virol. 1999 Apr;73(4):3023-31. Unique Identifier : AIDSLINE MED/99173999; Kaye JF; Lever AM; Department of Medicine, University of Cambridge, Addenbrooke's; Hospital, Cambridge, United Kingdom. jfk11@mole.bio.cam.ac.uk; Retroviral RNA encapsidation is a highly selective process mediated through recognition by the viral Gag proteins of cis-acting RNA packaging signals in genomic RNA. This RNA species is also translated, producing the viral gag gene products. The relationship between these processes is poorly understood. Unlike that of
Sequence and genomic analysis of a Rhesus macaque rhadinovirus with similarity to Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8.: J Virol. 1999 Apr;73(4):3040-53. Unique Identifier : AIDSLINE MED/99174001; Searles RP; Bergquam EP; Axthelm MK; Wong SW; Division of Pathobiology and Immunology, Oregon Health Sciences; University/Oregon Regional Primate Research Center, Beaverton,; Oregon 97006, USA.; We have sequenced the long unique region (LUR) and characterized the terminal repeats of the genome of a rhesus rhadinovirus (RRV), strain 17577. The LUR as sequenced is 131,364 bp in length, with a G+C content of 52.2% and a CpG ratio of 1.11. The genome codes for 79 open reading frames (ORFs), with 67 of these ORFs
T cells contribute to disease severity during coxsackievirus B4 infection.: J Virol. 1999 Apr;73(4):3080-6. Unique Identifier : AIDSLINE MED/99174005; Ramsingh AI; Lee WT; Collins DN; Armstrong LE; Wadsworth Center, New York State Department of Health, Albany,; New York 12201-2002, USA. arlene.ramsingh@wadsworth.org; By using a model of coxsackievirus B4-induced disease, the question of whether tissue damage is due to the virus or to immune-mediated mechanisms was addressed. Both viral replication and T-cell function were implicated in contributing to the severity of disease. Three stages (I to III) of disease, which correspond to
Protection of macaques against intrarectal infection by a combination immunization regimen with recombinant simian immunodeficiency virus SIVmne gp160 vaccines.: J Virol. 1999 Apr;73(4):3134-46. Unique Identifier : AIDSLINE MED/99174012; Polacino P; Stallard V; Montefiori DC; Brown CR; Richardson BA; Morton WR; Benveniste RE; Hu SL; Regional Primate Research Center, University of Washington,; Seattle, Washington, USA.; We previously reported that immunization with recombinant simian immunodeficiency virus SIVmne envelope (gp160) vaccines protected macaques against intravenous challenge by the cloned homologous virus E11S but that this protection was only partially effective against the uncloned virus, SIVmne. In the present study, w
Dissecting the role of the N-terminal domain of human immunodeficiency virus integrase by trans-complementation analysis.: J Virol. 1999 Apr;73(4):3176-83. Unique Identifier : AIDSLINE MED/99174017; van den Ent FM; Vos A; Plasterk RH; Division of Molecular Biology, The Netherlands Cancer Institute,; 1066 CX Amsterdam, The Netherlands.; The human immunodeficiency virus (HIV) integrase protein (IN) catalyzes two reactions required to integrate HIV DNA into the human genome: 3 processing of the viral DNA ends and integration. IN has three domains, the N-terminal zinc-binding domain, the catalytic core, and the C-terminal SH3 domain. Previously, it was
Mutational analysis of Vpr-induced G2 arrest, nuclear localization, and cell death in fission yeast.: J Virol. 1999 Apr;73(4):3236-45. Unique Identifier : AIDSLINE MED/99174024; Chen M; Elder RT; Yu M; O'Gorman MG; Selig L; Benarous R; Yamamoto A; Zhao Y; Children's Memorial Institute of Education and Research,; Northwestern University Medical School, Chicago, Illinois 60614,; USA.; Cell cycle G2 arrest, nuclear localization, and cell death induced by human immunodeficiency virus type 1 Vpr were examined in fission yeast by using a panel of Vpr mutations that have been studied previously in human cells. The effects of the mutations on Vpr functions were highly similar between fission yeast and hu
Interaction of Gli2 with CREB protein on DNA elements in the long terminal repeat of human T-cell leukemia virus type 1 is responsible for transcriptional activation by tax protein.: J Virol. 1999 Apr;73(4):3258-63. Unique Identifier : AIDSLINE MED/99174026; Dan S; Tanimura A; Yoshida M; Department of Cellular and Molecular Biology, Institute of; Medical Science, The University of Tokyo, Minato-ku, Tokyo 108,; Japan.; The long terminal repeat (LTR) of human T-cell leukemia virus type 1 (HTLV-1) has two distinct DNA elements, one copy of TRE2S and three copies of a 21-bp sequence that respond to the viral trans-activator protein, Tax. Either multiple copies of the 21-bp sequence or a combination of one copy each of TRE2S and 21-bp s
Comparison of immunity generated by nucleic acid-, MF59-, and ISCOM-formulated human immunodeficiency virus type 1 vaccines in Rhesus macaques: evidence for viral clearance.: J Virol. 1999 Apr;73(4):3292-300. Unique Identifier : AIDSLINE MED/99174030; Verschoor EJ; Mooij P; Oostermeijer H; van der Kolk M; ten Haaft P; Verstrepen B; Sun Y; Morein B; Akerblom L; Fuller DH; Barnett SW; Heeney JL; Department of Virology, Biomedical Primate Research Center,; Rijswijk, The Netherlands.; The kinetics of T-helper immune responses generated in 16 mature outbred rhesus monkeys (Macaca mulatta) within a 10-month period by three different human immunodeficiency virus type 1 (HIV-1) vaccine strategies were compared. Immune responses to monomeric recombinant gp120SF2 (rgp120) when the protein was expressed i
Irreversible inhibition of human immunodeficiency virus type 1 integrase by dicaffeoylquinic acids.: J Virol. 1999 Apr;73(4):3309-16. Unique Identifier : AIDSLINE MED/99174032; Zhu K; Cordeiro ML; Atienza J; Robinson WE Jr; Chow SA; Department of Molecular and Medical Pharmacology, UCLA School of; Medicine, Los Angeles, California 90095, USA.; Human immunodeficiency virus type 1 (HIV-1) and other retroviruses require integration of a double-stranded DNA copy of the RNA genome into the host cell chromosome for productive infection. The viral enzyme, integrase, catalyzes the integration of retroviral DNA and represents an attractive target for developing anti
Will multiple coreceptors need to be targeted by inhibitors of human immunodeficiency virus type 1 entry?: J Virol. 1999 Apr;73(4):3443-8. Unique Identifier : AIDSLINE MED/99174047; Zhang YJ; Moore JP; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, New York, USA.; Despite being able to use the Bonzo coreceptor as efficiently as CCR5 in transfected cells, pediatric human immunodeficiency virus type 1 isolate P6 was unable to replicate in peripheral blood mononuclear cells (PBMC) lacking the CCR5 receptor. Furthermore, its replication in wild-type PBMC was completely inhibited by
Human immunodeficiency virus type 1 derived from cocultures of immature dendritic cells with autologous T cells carries T-cell-specific molecules on its surface and is highly infectious.: J Virol. 1999 Apr;73(4):3449-54. Unique Identifier : AIDSLINE MED/99174048; Frank I; Kacani L; Stoiber H; Stossel H; Spruth M; Steindl F; Romani N; Dierich MP; Institute for Hygiene and Ludwig Boltzmann Institute for AIDS; Research, University of Innsbruck, Innsbruck, Austria.; During the budding process, human immunodeficiency virus type 1 (HIV-1) acquires cell surface molecules; thus, the viral surface of HIV-1 reflects the antigenic pattern of the host cell. To determine the source of HIV-1 released from cocultures of dendritic cells (DC) with T cells, immature DC (imDC), mature DC (mDC),
Effects of human immunodeficiency virus type 1 resistance to protease inhibitors on reverse transcriptase processing, activity, and drug sensitivity.: J Virol. 1999 Apr;73(4):3455-9. Unique Identifier : AIDSLINE MED/99174049; de la Carriere LC; Paulous S; Clavel F; Mammano F; Unite d'Oncologie Virale, Institut Pasteur and Laboratoire de; Recherche Antivirale, Hopital Bichat-Claude Bernard, Paris,; France.; Human immunodeficiency virus type 1 (HIV-1) variants resistant to protease inhibitors often display a reduced replicative capacity as a result of an impairment of protease function. Such fitness-impaired viruses display Gag precursor maturation defects. Here, we rep
Regulation of human immunodeficiency virus type 1 infectivity by the ERK mitogen-activated protein kinase signaling pathway.: J Virol. 1999 Apr;73(4):3460-6. Unique Identifier : AIDSLINE MED/99174050; Yang X; Gabuzda D; Department of Cancer Immunology and AIDS, Dana-Farber Cancer; Institute, Harvard Medical School, Boston, Massachusetts 02115,; USA.; ERK1 and ERK2 mitogen-activated protein kinases (MAPK) play a critical role in regulation of cell proliferation and differentiation in response to mitogens and other extracellular stimuli. Mitogens and cytokines that activate MAPK in T cells have been shown to activate human immunodeficiency virus type 1 (HIV-1) repli
Distinct human immunodeficiency virus strains in the bone marrow are associated with the development of thrombocytopenia.: J Virol. 1999 Apr;73(4):3497-504. Unique Identifier : AIDSLINE MED/99174056; Voulgaropoulou F; Tan B; Soares M; Hahn B; Ratner L; Departments of Medicine, Washington University, St. Louis,; Missouri 63110, USA.; We analyzed bone marrow and blood from human immunodeficiency virus type 1 (HIV-1)-infected individuals and described the HIV-1 quasispecies in these cellular compartments. HIV-1 isolates from the bone marrow of thrombocytopenic patients contained distinct amino acids in the V3 loop and infected T-cell lines, implicat
Arterial aneurysms in patients infected with human immunodeficiency virus: a distinct clinicopathology entity?: J Vasc Surg. 1999 Apr;29(4):600-7. Unique Identifier : AIDSLINE MED/99212106; Nair R; Abdool-Carrim A; Chetty R; Robbs J; Metropolitan Vascular Service and Department of Pathology,; University of Natal Medical School, Congella, South Africa.; Arterial aneurysms have only recently been associated with the human immunodeficiency virus (HIV). The clinical and pathological features of 10 HIV-positive patients with arterial aneurysms were retrospectively evaluated. These aneurysms were unusual in that they affected young black patients, occurred in atypical sit
Hemodialysis access: influence of the human immunodeficiency virus on patency and infection rates.: J Vasc Surg. 1999 Apr;29(4):608-16. Unique Identifier : AIDSLINE MED/99212107; Curi MA; Pappas PJ; Silva MB Jr; Patel S; Padberg FT Jr; Jamil Z; Duran WN; Hobson RW 2nd; Division of Vascular Surgery and Program in Vascular Biology,; Department of Surgery, University of Medicine and Dentistry of; New Jersey-New Jersey Medical School, Newark, USA.; PURPOSE: The complication rate for patients who are dialysis dependent and infected with the human immunodeficiency virus (HIV) and the role of viral indicators (CD4 counts) as predictors of these complications are poorly characterized. To determine the influence of HIV status and viral activity on graft patency and i
The global HIV/AIDS epidemic [news]: JAMA. 1999 Apr 28;281(16):1479. Unique Identifier : AIDSLINE MED/99241841; Satcher D
Euthanasia and end-of-life care [letter]: JAMA. 1999 Apr 28;281(16):1488. Unique Identifier : AIDSLINE MED/99241850; Colebunders R; Schrooten W
Compulsory drug licensing for countries hit by HIV is mooted [news]: Lancet. 1999 Apr 3;353(9159):1165. Unique Identifier : AIDSLINE MED/99224700; McGregor A
Th-2 type cytokine receptors in allergic rhinitis and in response to topical steroids.: Laryngoscope. 1999 Apr;109(4):551-6. Unique Identifier : AIDSLINE MED/99215922; Wright ED; Christodoulopoulos P; Small P; Frenkiel S; Hamid Q; Department of Otolaryngology, Sir Mortimer B. Davis Jewish; General Hospital, McGill University, Montreal, Quebec, Canada.; OBJECTIVES: Th-2 type cytokine production (Interleukin-4 [IL-4] and interleukin-5 [IL5]) has been demonstrated to play a significant role in the pathophysiology of allergic rhinitis (AR), and the treatment of AR with topical corticosteroids has been shown to reduce the expression of Th-2 type cytokines in vivo. Howeve
[Burkina Faso--a multitude of public health emergencies]: Med Trop (Mars). 1998;58(3):235-9. Unique Identifier : AIDSLINE MED/99188089; Niakara A; Ouedraogo N; Auregan G; Faculte des Sciences de la Sante, Centre National de Lutte; Anti-Tuberculeuse, Ouagadougou, Burkina Faso.; r.y.niakara@fasonet.bf
[Tropical myositis]: Med Trop (Mars). 1998;58(3):297-306. Unique Identifier : AIDSLINE MED/99188102; Saissy JM; Ducourau JP; Tchoua R; Diatta B; Departement d'Anesthesie-Reanimation, l'Hopital d'Instruction; des Armees Begin, Saint-Mande, France.; Tropical pyomyositis (TP) is a microbial infection involving one or more skeletal muscles that rapidly leads to abscess. The most common infectious agent is Staphylococcus aureus. Since muscle tissue is highly resistant to infection, occurrence of TP is contingent upon one or more compromising factors such as trauma,
Risk factors for human T cell lymphotropic virus type I among injecting drug users in northeast Brazil: possibly greater efficiency of male to female transmission.: Mem Inst Oswaldo Cruz. 1999 Jan-Feb;94(1):13-8. Unique Identifier : AIDSLINE MED/99154169; Dourado I; Andrade T; Carpenter CL; Galvao-Castro B; Instituto de Saude Coletiva Universidade Federal da Bahia,; Salvador, Brasil. maines@ufba.br; It was observed in the city of Salvador, State of Bahia, the highest seroprevalence of human T cell lymphotropic virus type 1 (HTLV-I) infection in Brazil as demonstrated by national wide blood bank surveys. In this paper, we report results of an investigation of drug use and sexua
Relationship between the human T-lymphotropic virus type 1 infection and clinical manifestations of tegumentary leishmaniasis in the Colombian Pacific Coast.: Mem Inst Oswaldo Cruz. 1999 Jan-Feb;94(1):19-20. Unique Identifier : AIDSLINE MED/99154170; Lenis AM; Blank A; Valderrama L; Saravia NG; Centro Internacional de Entrenamiento e Investigaciones Medicas; (CIDEIM), Cali, Colombia. cideim@cali.cetcol.net.co
Frequency of vaccine-related and therapeutic injections--Romania, 1998.: MMWR Morb Mortal Wkly Rep. 1999 Apr 9;48(13):271-4. Unique Identifier : AIDSLINE MED/99242361; In Romania and other countries, therapeutic injections have been associated with transmission of hepatitis B and C viruses, human immunodeficiency virus type 1 (HIV-1), and other bloodborne pathogens. During 1997-1998, acute hepatitis B was associated with recent injections in Rom
Penicilliosis marneffei and pythiosis: emerging tropical diseases.: Mycopathologia. 1998;143(1):3-7. Unique Identifier : AIDSLINE MED/99222613; Kaufman L; Division of Bacterial and Mycotic Diseases, Centers for Disease; Control and Prevention, Atlanta, Georgia 30333, USA.; Penicilliosis marneffei and pythiosis insidiosi are emerging infections in subtropical, tropical, and temperate areas of the world. Penicilliosis marneffei is endemic in several Southeast Asian countries and may be carried to other areas of the world by residents of these countries or visitors. Pythiosis occurs in hum
Response to cidofovir after failure of antiretroviral therapy alone in AIDS-associated progressive multifocal leukoencephalopathy.: Unique Identifier : AIDSLINE MED/99176642; De Luca A; Fantoni M; Tartaglione T; Antinori A; Istituto di Clinica delle Malattie Infettive, Universita; Cattolica S. Cuore, Rome, Italy.
Elevated subcortical choline metabolites in cognitively and clinically asymptomatic HIV+ patients.: Neurology. 1999 Mar 23;52(5):995-1003. Unique Identifier : AIDSLINE MED/99200542; Meyerhoff DJ; Bloomer C; Cardenas V; Norman D; Weiner MW; Fein G; Department of Veterans Affairs Medical Center, Department of; Radiology, University of California San Francisco, 94121, USA.; djmey@itsa.ucsf.edu; OBJECTIVE: To determine whether the concentrations of the neuronal marker N-acetylaspartate (NAA) and the choline-containing metabolites (Cho) are altered in the subcortical brain of HIV+ patients who are cognitively normal and clinically asymptomatic, and to determine whether these alterations are greater in the pres
The heterogeneity of glomerulonephritis associated with HIV [letter]: Nephrol Dial Transplant. 1999 Jan;14(1):244-5. Unique Identifier : AIDSLINE MED/99159891; Rivera M; Gonzalo A; Mampaso F; Teruel JL; Ortuno J
Methadone is poorly removed by haemodialysis [letter]: Nephrol Dial Transplant. 1999 Jan;14(1):254-5. Unique Identifier : AIDSLINE MED/99159901; Furlan V; Hafi A; Dessalles MC; Bouchez J; Charpentier B; Taburet AM
Effect of renal dialysis therapy modality on T cell cytokine production.: Nephrol Dial Transplant. 1999 Jan;14(1):49-55. Unique Identifier : AIDSLINE MED/99159841; Zamauskaite A; Perez-Cruz I; Yaqoob MM; Madrigal JA; Cohen SB; The Anthony Nolan Bone Marrow Trust, The Royal Free Hospital,; London, UK.; INTRODUCTION: Dialysis has been associated with acute changes in the complement activation status, granulocyte markers, macrophage function, T cell activation and the release of pro-inflammatory cytokines. The most common analysis of cytokine production in patients on dialysis has focused on the changes in monokines (
Metabolic complications of HIV disease.: Nurse Pract. 1999 Feb;24(2):125-6, 129. Unique Identifier : AIDSLINE MED/99157645; Swindells S; Department of Internal Medicine, University of Nebraska Medical; Center, USA.
A review of protease inhibitor-induced hyperglycemia.: Pharmacotherapy. 1999 Jan;19(1):114-7. Unique Identifier : AIDSLINE MED/99114123; Kaufman MB; Simionatto C; New York Medical Group, New York, USA.; Hyperglycemia is an adverse effect that occurs with all protease inhibitors , although few cases have been reported in the literature. Most patients with human immunodeficiency virus infection receiving antiretroviral therapy are also taking at least one protease inh
Human immunodeficiency virus protease inhibitors.: Pharmacotherapy. 1999 Jan;19(1):35-59. Unique Identifier : AIDSLINE MED/99114115; Rana KZ; Dudley MN; Antiinfective Pharmacology Research Unit, University of Rhode; Island College of Pharmacy, Roger Williams Medical Center,; Providence 02908, USA.; Human immunodeficiency virus (HIV) protease inhibitors have revolutionized the treatment of individuals infected with this pathogen. The protease is an enzyme that is essential for viral replication because it cleaves both structural and functional proteins from pre
Options for the management of mucosal candidiasis in patients with AIDS and HIV infection.: Unique Identifier : AIDSLINE MED/99114118; Vazquez JA; Oropharyngeal candidiasis may be the first manifestation of human immunodeficiency viral (HIV) infection, and more than 90% of patients with the acquired immunodeficiency syndrome (AIDS) develop the disease. Although numerous antifungal agents are available, azoles, both topical (clotrimazole) and systemic (fluconazol
Electron-beam therapy for AIDS-related molluscum contagiosum lesions: preliminary experience.: Unique Identifier : AIDSLINE MED/99223839; Scolaro MJ; Gordon P; A Medical Corporation, Beverly Hills, CA 90211, USA.; PURPOSE: To determine the effects of electron-beam therapy on cutaneous molluscum contagiosum lesions in patients with acquired immunodeficiency syndrome (AIDS), because current treatment modalities are limited in their effectiveness and by long-term rates of lesion recurrence. MATERIALS AND METHODS: Five patients wit
Progressive multifocal leukoencephalopathy and human immunodeficiency virus-associated white matter lesions in AIDS: magnetization transfer MR imaging.: Radiology. 1999 Feb;210(2):539-43. Unique Identifier : AIDSLINE MED/99223848; Ernst T; Chang L; Witt M; Walot I; Aronow H; Leonido-Yee M; Singer E; Department of Radiology, Harbor-UCLA Medical Center, Torrance; 90502, USA.; PURPOSE: To determine the magnetization transfer features of progressive multifocal leukoencephalopathy (PML) and human immunodeficiency virus (HIV)-associated white matter lesions (WML) (hereafter, HIV-WML) on magnetic resonance (MR) images obtained in patients with acquired immunodeficiency syndrome (AIDS). MATERIAL
Radioaerosol scintigraphy in infants and children born to mothers with HIV disease. Pediatric Pulmonary and Cardiovascular Complications (of Vertically Transmitted Human Immunodeficiency Virus) Study Group.: Radiology. 1999 Mar;210(3):815-22. Unique Identifier : AIDSLINE MED/99223893; Alderson PO; Chen DC; Fleishman MJ; Hoh CK; Kim CK; Lee VW; Mellins RB; Miller JH; Moore WH; Peavy HH; Shah A; Treves ST; Dept of Radiology, Columbia-Presbyterian Medical Center, New; York, NY 10032, USA.; PURPOSE: To determine the usefulness of technetium 99m diethyltriaminepentacetic acid (DTPA) radioaerosol inhalation-clearance scintigraphy for early detection of pulmonary complications of human immunodeficiency virus (HIV) disease in children. MATERIALS AND METHODS: A total of 301 studies were performed in 132 HIV-p
PCR-based diagnosis of a case of herpetic whitlow in an AIDS patient.: Rev Inst Med Trop Sao Paulo. 1998 Sep-Oct;40(5):317-9. Unique Identifier : AIDSLINE MED/99154345; Nogueira ML; Oliveira AF; Araujo JG; Gallo MA; Fonseca JG; Bonjardim CA; Ferreira PC; Kroon EG; Departamento de Microbiologia, Universidade Federal de Minas; Gerais, Belo Horizonte, Brasil.; Herpetic infections are common complications in AIDS patients. The clinical features could be uncommon and antiviral chemotherapy is imperative. A rapid diagnosis could prevent incorrect approaches and treatment. The polymerase chain reaction is a rapid, specific and sensible method for DNA amplification and diagnosis
Ethics on the job: a survey. The realities of HIV/AIDS.: RN. 1999 Apr;62(4):26-30; quiz 31. Unique Identifier : AIDSLINE MED/99239562; Ventura MJ; HIV/AIDS has had a profound impact on how care is provided to patients--raising both practice and ethical concerns. In this final installment in our series, we ll see how nurses are coping with these dilemmas, and how they feel about issues like mandatory HIV testing and practice restrictions on infected providers.
[Determination of HIV protein 24 in feces of Triatoma infestans fed with blood from AIDS patients]: Rev Saude Publica. 1998 Oct;32(5):464-6. Unique Identifier : AIDSLINE MED/99154331; Nuzzo SF; Amato Neto V; Braz LM; Silva M de F; de Oliveira ML; Castilho MA; de Carvalho SA; Laboratorio de Parasitologia, Instituto de Medicina Tropical de; Sao Paulo, Brasil.; OBJECTIVE: To verify any possibility of the elimination of p24 in feces of Triatoma infestans, p24 being an antigen and one of the markers of HIV infection. The purpose of the study was the evaluation of any risk of contamination by laboratory staff who work with activities related to this particular insect, and also
[Clinical epidemiology and treatment of tuberculosis in elderly patients]: Schweiz Med Wochenschr. 1999 Jan 23;129(3):80-9. Unique Identifier : AIDSLINE MED/99164905; Janssens JP; Zellweger JP; Departement de geriatrie, HUG, Geneve. janssens@iprolink.ch; In developed countries the incidence of tuberculosis is higher in patients aged 65 and over than in any other age group, with the exception of HIV positive subjects. This high incidence is a consequence of the very high rate of infection in our countries in the first part of the century, and of the diminished efficien
[Immunological investigation of hypogammaglobulinemia]: Tidsskr Nor Laegeforen. 1999 Mar 10;119(7):940-3. Unique Identifier : AIDSLINE MED/99227400; Jureen R; Ulvestad E; Avdeling for mikrobiologi og immunologi Gades Institutt,; Haukeland Sykehus, Bergen.; Immunoglobulin deficiency syndromes should be considered in patients with recurrent respiratory tract infections or in patients with infections caused by agents of low virulence. We present two patients with a clinical history of recurrent respiratory tract infections. Both patients had a humoral immunodeficiency char
Virus reduction in the preparation of intravenous immune globulin: in vitro experiments.: Transfusion. 1999 Mar;39(3):249-57. Unique Identifier : AIDSLINE MED/99219280; Chandra S; Cavanaugh JE; Lin CM; Pierre-Jerome C; Yerram N; Weeks R; Flanigan E; Feldman F; U.S. Pre-Clinical Research & Development, Centeon L.L.C.,; Bradley, Illinois, USA.; BACKGROUND: While immune globulins for intravenous administration (IGIV) have an excellent record with respect to virus safety, concern regarding these preparations has been raised by reports of transmission of hepatitis C virus (HCV) to patients treated with IGIV and the presence of genetic material for HCV in IGIV p
Chemokines and chemokine receptors in the CNS: a possible role in neuroinflammation and patterning.: Trends Pharmacol Sci. 1999 Feb;20(2):73-8. Unique Identifier : AIDSLINE MED/99202196; Mennicken F; Maki R; de Souza EB; Quirion R; Douglas Hospital Research Center, Verdun, Quebec, Canada.; Chemokines constitute a growing family of structurally and functionally related small (8-10 kDa) proteins associated with inflammatory-cell recruitment in host defence. In addition to their well-established role in the immune system, recent data suggest their involvement in the maintenance of CNS homeostasis, in neuro
Comparative ultrastructural studies on mitochondrial pathology in the liver of AIDS patients: clusters of mitochondria, protuberances, "minimitochondria," vacuoles, and virus-like particles.: Ultrastruct Pathol. 1999 Jan-Feb;23(1):19-24. Unique Identifier : AIDSLINE MED/99184717; Radovanovic J; Todorovic V; Boricic I; Jankovic-Hladni M; Korac A; Institute of Zoology, Faculty of Biology, University of Belgrade,; Serbia, Yugoslavia. jelenar@bf.bio.bg.ac.yu; The present comparative conventional electron microscopic studies of the liver biopsy in 20 AIDS patients revealed numerous disintegrated mitochondria in hepatocytes, Kupffer cells lymphocytes, and eosinophile leukocytes. It was observed that (1) AIDS mitochondria are clustered, disorganized, and with protuberances; (
Fibrous long-spacing collagen in Kaposi's sarcoma [letter]: Ultrastruct Pathol. 1999 Jan-Feb;23(1):59. Unique Identifier : AIDSLINE MED/99184723; Marquart KH
The use of two immunosuppressive drugs, cyclosporin A and tacrolimus, to inhibit virus replication and apoptosis in cells infected with feline immunodeficiency virus.: Vet Res Commun. 1998 Dec;22(8):553-63. Unique Identifier : AIDSLINE MED/99164012; Mortola E; Endo Y; Ohno K; Watari T; Tsujimoto H; Hasegawa A; Graduate School of Agriculture and Life Sciences, The University; of Tokyo, Japan.; An in vitro model of acute and chronic infections with feline immunodeficiency virus (FIV) was used to examine the effect of two immunosuppressive agents, cyclosporin A (CsA) and tacrolimus (also known as FK506), on the inhibition of the replication of the virus and of apoptosis. Both drugs significantly suppressed vi
U937 cells overexpressing bcl-xl are resistant to human immunodeficiency virus-1-induced apoptosis and human immunodeficiency virus-1 replication.: Virology. 1999 Mar 30;256(1):1-7. Unique Identifier : AIDSLINE MED/99189356; Marshall WL; Datta R; Hanify K; Teng E; Finberg RW; Dana-Farber Cancer Institute, Boston, Massachusetts, 02115, USA.; bill_marshall@macmailgw.dfci.harvard.edu; Many viruses, including human immunodeficiency virus type 1 (HIV-1), induce apoptosis and are affected by cellular expression of antiapoptotic genes. We sought to examine the effect of antiapoptotic gene expression on HIV replication by transfecting the promyelomonocytic cell line U937 with the bcl-xl gene to obtain c
Viral burden and disease progression in rhesus monkeys infected with chimeric simian-human immunodeficiency viruses.: Virology. 1999 Mar 30;256(1):15-21. Unique Identifier : AIDSLINE MED/99189358; Reimann KA; Watson A; Dailey PJ; Lin W; Lord CI; Steenbeke TD; Parker RA; Axthelm MK; Karlsson GB; Division of Viral Pathogenesis, Beth Israel Deaconess Medical; Center, Boston, Massachusetts 02215, USA.; kreimann@caregroup.harvard.edu; To determine the role of viral burden in simian-human immunodeficiency virus (SHIV)-induced disease, cellular provirus and plasma viral RNA levels were measured after inoculation of rhesus monkeys with four different SHIVs. These SHIVs included SHIV-HXBc2 and SHIV-89.6, constructed with env, tat, rev, and vpu derived
Characterization of a neutralization-escape variant of SHIVKU-1, a virus that causes acquired immune deficiency syndrome in pig-tailed macaques.: Virology. 1999 Mar 30;256(1):54-63. Unique Identifier : AIDSLINE MED/99189362; Narayan SV; Mukherjee S; Jia F; Li Z; Wang C; Foresman L; McCormick-Davis C; Stephens EB; Joag SV; Narayan O; Department of Microbiology, Molecular Genetics and Immunology,; University of Kansas Medical Center, 3901 Rainbow Boulevard,; Kansas City, Kansas 66160-7420, USA.; A chimeric simian-human immunodeficiency virus (SHIV-4) containing the tat, rev, vpu, and env genes of HIV type 1 (HIV-1) in a genetic background of SIVmac239 was used to develop an animal model in which a primate lentivirus expressing the HIV-1 envelope glycoprotein caused acquired immune deficiency syndrome (AIDS) i
Strict conservation of the retroviral nucleocapsid protein zinc finger is strongly influenced by its role in viral infection processes: characterization of HIV-1 particles containing mutant nucleocapsid zinc-coordinating sequences.: Virology. 1999 Mar 30;256(1):92-104. Unique Identifier : AIDSLINE MED/99189366; Gorelick RJ; Gagliardi TD; Bosche WJ; Wiltrout TA; Coren LV; Chabot DJ; Lifson JD; Henderson LE; Arthur LO; SAIC Frederick, National Cancer Institute, Frederick, Maryland,; 21702-1201, USA.gorelick@avpaxp1.ncifcrf.gov; The retroviral nucleocapsid (NC) protein contains highly conserved amino acid sequences (-Cys-X2-Cys-X4-His-X4-Cys-) designated retroviral (CCHC) Zn2+ fingers. The NC protein of murine leukemia viruses contains one NC Zn2+ finger and mutants that were competent in metal binding (CCCC and CCHH) packaged wild-type level
Prevalence and correlates of hepatitis C virus infection among inmates entering the California correctional system.: West J Med. 1999 Mar;170(3):156-60. Unique Identifier : AIDSLINE MED/99230717; Ruiz JD; Molitor F; Sun RK; Mikanda J; Facer M; Colford JM Jr; Rutherford GW; Ascher MS; California Department of Health Services, Office of AIDS,; Sacramento 95814, USA.; To estimate the prevalence and predictors of hepatitis C virus (HCV) infection among inmates, a cross-sectional survey was conducted in 1994 among inmates entering six reception centers of the California Department of Corrections. Discarded serum samples were tested for antibodies to human immunodeficiency virus (HIV)
Priming of CD8+ CTL effector cells in mice by immunization with a stress protein-influenza virus nucleoprotein fusion molecule.: Vaccine. 1999 Jan 28;17(4):373-83. Unique Identifier : AIDSLINE MED/99141650; Anthony LS; Wu H; Sweet H; Turnnir C; Boux LJ; Mizzen LA; StressGen Biotechnologies Corporation, Victoria, BC, Canada.; lanthony@stressgen.com; Literature is accumulating which suggests the potential for stress proteins to form the basis of a novel vaccine technology. Immunization with mammalian tumor-derived stress proteins and their associated peptides promote anti-tumor immunity. Vaccination with HIV-1 p24 antigen fused to mycobacterial heat shock protein
Tonsillar lymphoma and AIDS.: Acta Otorhinolaryngol Belg. 1999;53(1):73-8. Unique Identifier : AIDSLINE MED/99202271; Delbrouck C; Chantrain G; Damry N; Kampouridis S; Dept of ENT, CHU St. Pierre, Brussels.; A case of a patient presenting unilateral tonsillar enlargement, whereby non-Hodgkin lymphoma (NHL) and AIDS were diagnosed, is presented. The clinical and pathological aspects of this pathology, its pathogenicity and treatment are reviewed.
[Cardiovascular morbidity in children with human immunodeficiency virus infection]: Acta Med Port. 1998 Dec;11(12):1051-7. Unique Identifier : AIDSLINE MED/99209056; Nogueira G; Macedo AJ; Paixao A; Nunes MA; Ferreira M; Bernardino L; Bessa A; Rosado L; Kaku S; Costa MG; Servico de Cardiologia Pediatria, Hospital de Santa Marta,; Lisboa.; Abnormalities of cardiovascular structure and function have been described among children with human immunodeficiency virus (HIV). In order to evaluate their occurrence and clinical predictors, 32 children infected with HIV, aged three months to 13 years (mean age = 3.11 +/- 3.51 years) were studied. Perinatal transmi
[Tuberculosis and the kidney]: Acta Med Port. 1998 Dec;11(12):1107-11. Unique Identifier : AIDSLINE MED/99209066; Gusmao L; Galvao J; Alfarroba E; Unidade de Nefrologia e Hemodialise, Hospital Militar Principal,; Lisboa.; There has been a recrudescence of tuberculosis, an ancient disease with recent control by public hygiene and drug therapy. Factors leading to the increased incidence of tuberculosis include the high incidence of tuberculosis among the AIDS population, and the emergence of drug-resistant strains of tuberculosis. In ren
Resolving the common clinical dilemmas of syphilis.: Am Fam Physician. 1999 Apr 15;59(8):2233-40, 2245-6. Unique Identifier : AIDSLINE MED/99236497; Birnbaum NR; Goldschmidt RH; Buffett WO; Department of Family and Community Medicine at the University of; California-San Francisco School of Medicine, USA.; The diagnosis and treatment of syphilis can present difficult dilemmas. Serologic tests can be negative if they are performed at the stage when lesions are present, and the VDRL test can be negative in patients with late syphilis. Cerebrospinal fluid examination is not required in patients with primary or secondary di
Disclosing diagnosis to children with HIV [news]: Am Fam Physician. 1999 Apr 15;59(8):2367. Unique Identifier : AIDSLINE MED/99236502; Rose VL
Crystal-induced acute renal failure.: Am J Med. 1999 Apr;106(4):459-65. Unique Identifier : AIDSLINE MED/99239756; Perazella MA; Department of Medicine, Yale University School of Medicine, New; Haven, Connecticut 06520-8029, USA.; Several medications--notably acyclovir , sulfonamides, methotrexate, indinavir , and triamterene--are associated with the production of crystals that are insoluble in human urine. Intratubular precipitation of the
An immunological assay for determination of baculovirus titers in 48 hours.: Anal Biochem. 1999 Mar 15;268(2):173-8. Unique Identifier : AIDSLINE MED/99177016; Kitts PA; Green G; CLONTECH Laboratories Inc., 1020 East Meadow Circle, Palo Alto,; California, 94303, USA. kitts@ncbi.nlm.nih.gov; Th baculovirus expression system is a system of choice for expressing eukaryotic proteins. Large amounts of biologically active material can be generated using this system by infecting insect cells with a baculovirus expressing the target protein. At several stages during the production of a baculovirus stock, it is n
Shedding of feline immunodeficiency virus in semen of domestic cats during acute infection.: Am J Vet Res. 1999 Feb;60(2):211-5. Unique Identifier : AIDSLINE MED/99156299; Jordan HL; Liang Y; Hudson LC; Tompkins WA; Department of Microbiology, Pathology, and Parasitology, College; of Veterinary Medicine, North Carolina State University, Raleigh; 27606, USA.; OBJECTIVE: To examine shedding of cell-free and cell-associated feline immunodeficiency virus (FIV) in semen of domestic cats during acute infection. ANIMALS: 7 specific-pathogen-free sexually intact male cats. PROCEDURE: 6 cats were inoculated IV with 5 x 10(6) 50% tissue culture infective doses of FIV-NCSU1, and 1 c
Chemokines and chemokine receptors: biology and clinical relevance in inflammation and AIDS.: Annu Rev Med. 1999;50:425-40. Unique Identifier : AIDSLINE MED/99172942; Locati M; Murphy PM; Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy.; locati@irfmn.mnegri.it; Chemokines constitute a large family of chemotactic cytokines that act at G protein-coupled receptors to regulate diverse biological processes, including leukocyte trafficking, angiogenesis, hematopoiesis, and organogenesis. They are believed to be both beneficial in host defense against infectious agents and harmful
[Progress in the chemotherapy of HIV-infection and AIDS (according to the materials of the Symposium "Highly Active Antiretrovirus Therapy")]: Antibiot Khimioter. 1999;44(1):36-8. Unique Identifier : AIDSLINE MED/99195658; Galegov GA
Determinants of short- and long-term outcome in patients with respiratory failure caused by AIDS-related Pneumocystis carinii pneumonia.: Arch Intern Med. 1999 Apr 12;159(7):741-7. Unique Identifier : AIDSLINE MED/99233123; Forrest DM; Zala C; Djurdjev O; Singer J; Craib KJ; Lawson L; Russell JA; Montaner JS; British Columbia Center for Excellence in HIV/AIDS, Division of; Critical Care Medicine, University of British Columbia,; Vancouver, Canada.; OBJECTIVES: To determine (1) predictors of in-hospital mortality and long-term survival in patients with acute respiratory failure (ARF) caused by acquired immunodeficiency syndrome-related Pneumocystis carinii pneumonia (PCP) and (2) long-term survival for patients with ARF relative to those without ARF. METHODS: A r
Chronic renal insufficiency [letter]: Arch Intern Med. 1999 Apr 12;159(7):757. Unique Identifier : AIDSLINE MED/99233127; Hirsch RL
A population with short delay from diagnosis of human immunodeficiency virus to medical care [letter]: Arch Intern Med. 1999 Apr 12;159(7):758-9. Unique Identifier : AIDSLINE MED/99233128; Guenter CD; Gill MJ
[Electroneuromyography and somatosensory evoked potentials in HTLV-I associated myelopathy]: Arq Neuropsiquiatr. 1998 Dec;56(4):756-62. Unique Identifier : AIDSLINE MED/99154140; Cruz MW; Correa RB; Puccioni-Sohler M; Novis SA; Servico de Neurologia Hospital Universitario Clementino Fraga; Filho da Universidade Federal do Rio de Janeiro, Brasil.; The objective of the present study was to correlate electroneuromyography (ENMG) and evoked potentials findings with clinical aspects and intrathecal synthesis of HTLV-I antibodies production on HTLV-I myelopathy (HAM). Patients were seropositive for HTLV-I by different assays and seronegative for HIV and VDRL. They h
[Neurologic evaluation of non-Hodgkin's lymphoma in adult patients: a prospective study]: Arq Neuropsiquiatr. 1998 Dec;56(4):763-8. Unique Identifier : AIDSLINE MED/99154141; Mielli SR; Livramento JA; Hospital das Clinicas (HC)/FMUSP, Brasil.; This prospective study included 67 adult patients with low, intermediate or high malignancy degrees of non-Hodgkin s lymphomas according to the Working Formulation. Patients with or without anti-HIV antibodies in the serum were considered. All patients were submitted to neurologic evaluation, and 63 of them to examina
[Non-Hodgkin lymphoma in adults. Protein profile of CSF and serum in 25 patients]: Unique Identifier : AIDSLINE MED/99154142; Mielli SR; Beitler B; Galperin C; Palou VB; Livramento JA; Machado L dos R; Gomes HR; Twenty-five non-Hodgkin s adult patients of a cohort studied for detection of neurologic involvement were evaluated on the cerebrospinal fluid (CSF) protein profile. CSF and serum were collected in the same occasion. Blood-brain barrier and local synthesis of IgG were studied. There was an incidence of neurologic sign
Expression of murine HOXD9 during embryonic joint patterning and in human T lymphotropic virus type I tax transgenic mice with arthropathy resembling rheumatoid arthritis.: Arthritis Rheum. 1999 Apr;42(4):686-96. Unique Identifier : AIDSLINE MED/99226864; Khoa ND; Hasunuma T; Kobata T; Kato T; Nishioka K; St. Marianna University School of Medicine, Kawasaki, Japan.; OBJECTIVE: To characterize the expression of murine HOXD9 during normal joint development and in arthritic joints of human T lymphotropic virus type I (HTLV-I) tax transgenic mice and the role of HTLV-I tax in HOXD9 expression. METHODS: Expression of HOXD9, HOXD1O, HOXD11, HOXD12, and HOXD13 genes in joint tissues at
Cytokine profiles in Wegener's granulomatosis: predominance of type 1 (Th1) in the granulomatous inflammation.: Arthritis Rheum. 1999 Apr;42(4):742-50. Unique Identifier : AIDSLINE MED/99226871; Csernok E; Trabandt A; Muller A; Wang GC; Moosig F; Paulsen J; Schnabel A; Gross WL; Medical University of Lubeck/Rheumaklinik Bad Bramstedt, Bad; Bramstedt, Germany.; OBJECTIVE: To determine whether a specific cytokine pattern (type 1 [Th1] or type 2 [Th2]) predominates in Wegener s granulomatosis (WG), by evaluating interferon-gamma (IFNgamma) and interleukin-4 (IL-4) expression in different compartments of the body (i.e., biopsied nasal mucosal tissue [NBS], bronchoalveolar lavag
Pneumocystis carinii pneumonia in patients with connective tissue diseases: the role of hospital experience in diagnosis and mortality.: Arthritis Rheum. 1999 Apr;42(4):780-9. Unique Identifier : AIDSLINE MED/99226876; Ward MM; Donald F; Department of Veterans Affairs Palo Alto Health Care System,; California, USA.; OBJECTIVE: Pneumonia due to Pneumocystis carinii has been increasingly reported in patients with connective tissue diseases, but the frequency of this complication is not known. We sought to determine the frequency of P carinii pneumonia (PCP) in patients with connective tissue diseases, and to determine the role that
Antisense activity of an anti-HIV oligonucleotide conjugated to linear and branched high molecular weight polyethylene glycols.: Farmaco. 1998 Oct-Nov;53(10-11):634-7. Unique Identifier : AIDSLINE MED/99222582; Bonora GM; Tocco G; Zaramella S; Veronese FM; Pliasunova O; Pokrovsky A; Ivanova E; Zarytova V; Institute of Molecular Virology, Novosibirsk, Russia.; An anti-HIV 12mer oligonucleotide (ODN) conjugated to two different high molecular weight monomethoxy polyethylene glycols (MPEGs) has been tested for its antisense activity. The capacity of these conjugates to protect the MT-4 cells against HIV infection has been compared to the unmodified, native ODN, and the effect
Lung fibrosis induced by silica particles in NMRI mice is associated with an upregulation of the p40 subunit of interleukin-12 and Th-2 manifestations.: Am J Respir Cell Mol Biol. 1999 Apr;20(4):561-72. Unique Identifier : AIDSLINE MED/99201411; Huaux F; Lardot C; Arras M; Delos M; Many MC; Coutelier JP; Buchet JP; Renauld JC; Lison D; Industrial Toxicology and Occupational Medicine Unit and; Laboratory of Pathology, Hospital of Mont Godinne, Yvair.; huaux@toxi.ucl.ac.be; Interleukin (IL)-12 is a cytokine produced principally by activated macrophages which is involved in control of the T-helper 1/T-helper 2 cell (Th1/Th2) polarization of immune responses. To examine its potential involvement in the development of lung fibrosis, we examined the expression (protein, messenger RNA [mRNA])
Th1- and Th2-type cytokines regulate the expression and production of eotaxin and RANTES by human lung fibroblasts.: Am J Respir Cell Mol Biol. 1999 Apr;20(4):777-86. Unique Identifier : AIDSLINE MED/99201435; Teran LM; Mochizuki M; Bartels J; Valencia EL; Nakajima T; Hirai K; Schroder JM; Department of Allergy and Dermatology, University of Kiel, Kiel,; Germany.; Eosinophils (Eos) and fibroblasts are known to play a major role in the pathogenesis of bronchial asthma and fibrotic lung disease. Therefore, we investigated whether Th1 and Th2 cytokines stimulate the production of Eo-activating chemokines by lung fibroblasts. Analyses of the culture supernatant using multiple steps
Hodgkin's disease in 35 patients with HIV infection: an experience with epirubicin, bleomycin, vinblastine and prednisone chemotherapy in combination with antiretroviral therapy and primary use of G-CSF.: Ann Oncol. 1999 Feb;10(2):189-95. Unique Identifier : AIDSLINE MED/99193648; Errante D; Gabarre J; Ridolfo AL; Rossi G; Nosari AM; Gisselbrecht C; Kerneis Y; Mazzetti F; Vaccher E; Talamini R; Carbone A; Tirelli U; Division of Medical Oncology, Aviano Cancer Center, Italy.; BACKGROUND: The optimal therapeutic approach for patients with Hodgkin s disease and human immunodeficiency virus infection (HD-HIV) is unknown. In an attempt to improve the results previously obtained with EBV (epirubicin, bleomycin and vinblastine) without G-CSF (Cancer 1994; 73: 437-44), in January 1993 we started
Characterization of CD4+ CD8alphaalpha+ and CD4-CD8alphaalpha+ intestinal intraepithelial lymphocytes in rats.: Int Immunol. 1999 Jan;11(1):21-8. Unique Identifier : AIDSLINE MED/99157957; Yamada K; Kimura Y; Nishimura H; Namii Y; Murase M; Yoshikai Y; Research Institute for Disease Mechanism and Control, Department; of Thoracic Surgery, Nagoya University School of Medicine, Japan.; Intestinal intraepithelial lymphocytes (i-IEL) of aged rats comprise CD4+CD8alphaalpha+ and CD4-CD8alphaalpha+ T cells expressing TCR alphabeta. In the present study, we compared characteristics between CD4+CD8alphaalpha+ and CD4-CD8alphaalpha+ i-IEL, which were purified by a cell sorter from the i-IEL of 6-month-old
Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine.: Int Immunol. 1999 Jan;11(1):81-8. Unique Identifier : AIDSLINE MED/99157963; Imai T; Nagira M; Takagi S; Kakizaki M; Nishimura M; Wang J; Gray PW; Matsushima K; Yoshie O; Shionogi Institute for Medical Science, Settsu, Osaka, Japan.; Helper T cells are classified into Th1 and Th2 subsets based on their profiles of cytokine production. Th1 cells are involved in cell-mediated immunity, whereas Th2 cells induce humoral responses. Selective recruitment of these two subsets depends on specific adhesion molecules and specific chemoattractants. Here, we
CD45 can act as a negative regulator for the transition from early to late CD4+ CD8+ thymocytes.: Int Immunol. 1999 Jan;11(1):89-97. Unique Identifier : AIDSLINE MED/99157964; Sato T; Nunomura S; Sato C; Hozumi K; Kumagai Y; Nishimura T; Mak TW; Kishihara K; Habu S; Department of Immunology, Tokai University School of Medicine,; Isehara, Kanagawa, Japan.; The differentiation process from CD4-CD8- double-negative (DN) thymocytes to CD4+CD8+ double-positive (DP) stage is accompanied by vigorous proliferation. The resulting DP cells contain a sizable proportion of large cycling cells, but most DP cells are small resting cells. To explore the molecular mechanisms which reg
Controlling human immunodeficiency virus type 1 gene expression by unnatural peptides.: Biochemistry. 1999 Apr 20;38(16):5172-7. Unique Identifier : AIDSLINE MED/99230211; Huq I; Ping YH; Tamilarasu N; Rana TM; Department of Pharmacology, Robert Wood Johnson Medical School,; Molecular Biosciences Graduate Program, Rutgers University,; Piscataway, New Jersey 08854, USA.; Small unnatural peptides that target specific RNA structures have the potential to control biological processes. RNA-protein interactions are important in many cellular functions, including transcription, RNA splicing, and translation. One example of such interactions is the mechanism of trans-activation of human immu
Kinetic analysis of the effect of HIV nucleocapsid protein (NCp) on internal strand transfer reactions.: Biochemistry. 1999 Apr 20;38(16):5178-84. Unique Identifier : AIDSLINE MED/99230212; Raja A; DeStefano JJ; Department of Cell Biology and Molecular Genetics, University of; Maryland College Park, College Park 20742, USA.; The mechanism of HIV reverse transcriptase (RT) catalyzed strand transfer synthesis (i.e., switching of the primer to a new template) from internal regions on RNA templates in the presence and absence of HIV nucleocapsid protein (NCp) was investigated. Two different systems each consisting of DNA-primed RNA donor (on
Solution structure and orientation of the transmembrane anchor domain of the HIV-1-encoded virus protein U by high-resolution and solid-state NMR spectroscopy.: Biochemistry. 1999 Apr 20;38(16):5272-82. Unique Identifier : AIDSLINE MED/99230223; Wray V; Kinder R; Federau T; Henklein P; Bechinger B; Schubert U; Department of Molecular Structure Research, Gesellschaft fur; Biotechnologische Forschung, Braunschweig, Germany.; The structure of the membrane anchor domain (VpuMA) of the HIV-1-specific accessory protein Vpu has been investigated in solution and in lipid bilayers by homonuclear two-dimensional and solid-state nuclear magnetic resonance spectroscopy, respectively. Simulated annealing calculations, using the nuclear Overhauser en
DNA from both high-capacity and first-generation adenoviral vectors remains intact in skeletal muscle.: Hum Gene Ther. 1999 Feb 10;10(3):365-73. Unique Identifier : AIDSLINE MED/99156134; Chen HH; Mack LM; Choi SY; Ontell M; Kochanek S; Clemens PR; Department of Neurology, University of Pittsburgh, PA 15213, USA.; Previous studies of the use of adenoviral vectors in animal models of gene therapy have focused on the immune response against transduced cells as the major limiting factor to long-term transgene expression. In this study we eliminated the variable of immunity induced by expression of the transgene in order to investi
Long-lasting anti-metastatic efficiency of interleukin 12-encoding plasmid DNA.: Hum Gene Ther. 1999 Feb 10;10(3):407-17. Unique Identifier : AIDSLINE MED/99156138; Schultz J; Pavlovic J; Strack B; Nawrath M; Moelling K; Institute of Medical Virology, University of Zurich, Switzerland.; Intramuscular injection of plasmid DNA encoding both subunits of the cytokine interleukin 12 (IL-12) exhibits strong antimetastatic activity against lung metastases induced by the malignant melanoma cell line B16-F10. The protective effect of IL-12 DNA is long-lasting, since administration of tumor cells 9 days after
Macaque lymphocytes transduced by a constitutively expressed interferon beta gene display an enhanced resistance to SIVmac251 infection.: Hum Gene Ther. 1999 Feb 10;10(3):429-40. Unique Identifier : AIDSLINE MED/99156140; Matheux F; Le Grand R; Rousseau V; De Maeyer E; Dormont D; Lauret E; CEA, Service de Neurovirologie (DSV/DRM), CRSSA, Institut Paris; Sud sur les Cytokines, Fontenay aux Roses, France.; We are developing a method of gene therapy of HIV infection based on the low constitutive expression of an interferon beta (IFN-beta) gene in HIV target cells. Herein we report the first step in the development of a relevant animal model, provided by the macaque (Macaca fascicularis) infected with a pathogenic SIVmac2
Interference between effector RNAs expressed from conventional dual-function anti-HIV retroviral vectors can be circumvented using dual-effector-cassette retroviral vectors.: Hum Gene Ther. 1999 Feb 10;10(3):449-62. Unique Identifier : AIDSLINE MED/99156142; Peng H; Callison D; Li P; Burrell CJ; National Centre for HIV Virology Research, Infectious Diseases; Laboratories Institute of Medical and Veterinary Science,; Adelaide, South Australia, Australia. Pengh@ll.visn22.med.va.gov; Coexpression of different effector molecules from a single vector (a dual-function vector) may provide enhanced efficacy. Thus far most of the reported anti-HIV dual-function vectors express different effector RNAs as a chimeric molecule. In our study involving retroviral vectors coexpressing a U5 ribozyme and either
A validated method for the determination of paracetamol and its glucuronide and sulphate metabolites in the urine of HIV+/AIDS patients using wavelength-switching UV detection.: J Pharm Biomed Anal. 1998 Sep 1;17(6-7):1191-7. Unique Identifier : AIDSLINE MED/99098678; Di Girolamo A; O'Neill WM; Wainer IW; Departement de Pharmacologie, Faculte de Medecine, Universite; de Montreal, Quebec, Canada.; Paracetamol is a safe drug which has been used as an in-vivo probe to determine phase II metabolism in a HIV+/AIDS population. Due to the biohazard nature of HIV-infected samples, a high performance liquid chromatography (HPLC) assay which offers minimal sample manipulation and maximal specificity was developed. This
T-cell lymphoma in a savanna monkey (Cercopithecus aethiops) probably related to simian T-cell leukemia virus infection.: J Vet Med Sci. 1999 Jan;61(1):49-52. Unique Identifier : AIDSLINE MED/99151226; Sato Y; Matsuura S; Kadota K; Miyazawa I; Ueda Livestock Hygiene Service Center, Nagano, Japan.; Lymphoma was seen in an 11-year-old female savanna monkey (Ceropithecus aethiops). The superficial inguinal and visceral lymph nodes were markedly enlarged, and their architecture was completely effaced by neoplastic cells. The neoplastic cells, which were highly pleomorphic, resembled those in adult T-cell lymphoma-l
Feline immunodeficiency virus subtype C is prevalent in northern part of Taiwan.: J Vet Med Sci. 1999 Feb;61(2):197-9. Unique Identifier : AIDSLINE MED/99181617; Uema M; Ikeda Y; Miyazawa T; Lin JA; Chen MC; Kuo TF; Kai C; Mikami T; Takahashi E; Department of Veterinary Microbiology, Graduate School of; Agricultural and Life Sciences, University of Tokyo, Japan.; The seroepidemiological survey of cats conducted in northern part of Taiwan in 1998 revealed that the positive rate of feline immunodeficiency virus (FIV)-infection was 21.9% (7/32) and the rate was much higher than those of previou
Heterozygous defect in HIV-1 coreceptor CCR5 and chemokine production.: Cytokine. 1999 Jan;11(1):1-7. Unique Identifier : AIDSLINE MED/99182540; Yang JY; Togni M; Widmer U; Division of Clinical Immunology, Department of Medicine,; University Hospital, CH-8091 Zurich, Switzerland.; CC chemokine receptor 5 (CCR5) is a cell entry cofactor for macrophage-tropic isolates of human immunodeficiency virus 1 (HIV-1). An inactive CCR5 allele with a 32-nucleotide deletion (CCR5Delta32) has been described that confers resistance to HIV-1 infection in homozygotes and slows the rate of progression to AIDS in
Chemical synthesis and characterization of chemokine RANTES and its analogues.: Cytokine. 1999 Jan;11(1):8-15. Unique Identifier : AIDSLINE MED/99182541; Boykins RA; Oravecz T; Unsworth E; Syin C; Division of Allergenic Products and Parasitology, Center for; Biologics Evaluation and Research, Food and Drug Administration,; Bethesda, MD 20892, USA.; RANTES, a polypeptide of 68 amino acid residues, is a member of the C-C chemokine subfamily including other monocyte chemoattractants such as MIP-1alpha, MIP-1beta, MCP-1, MCP-2 and MCP-3. To provide a chemically defined RANTES in quantity suitable for structure-function studies, RANTES and its analogues were synthesi
Th1 and Th2 cytokine mRNA profiles in childhood nephrotic syndrome: evidence for increased IL-13 mRNA expression in relapse.: J Am Soc Nephrol. 1999 Mar;10(3):529-37. Unique Identifier : AIDSLINE MED/99171611; Yap HK; Cheung W; Murugasu B; Sim SK; Seah CC; Jordan SC; Department of Pediatrics, National University of Singapore,; Singapore. paeyaphk@nus.edu.sg; Idiopathic nephrotic syndrome of childhood is thought to be associated with T lymphocyte dysfunction often triggered by viral infections, with the production of circulating factor(s) resulting in proteinuria. In view of the conflicting evidence of T cell activation and Th1 or Th2 pattern of cytokine synthesis in this
Intragraft cytokine expression in tolerant rat renal allografts with rapamycin and cyclosporin immunosuppression.: Clin Transplant. 1999 Feb;13(1 Pt 2):90-7. Unique Identifier : AIDSLINE MED/99181484; Saggi BH; Fisher RA; Naar JD; Bu D; Obias V; Tawes JW; Wakely PE Jr; Posner MP; Medical College of Virginia, Virginia Commonwealth University,; Richmond 23298-0254, USA.; The Th-1/Th-2 paradigm proposes clonal expansion of Th-2 lymphocytes as the basis of tolerance towards allografts. Intragraft cytokine expression was evaluated in a highly stringent model of renal transplantation. ACI and Lewis rats were used as donors and recipients, respectively, for heterotopic renal transplantatio
Protein backbone angle restraints from searching a database for chemical shift and sequence homology.: J Biomol NMR. 1999 Mar;13(3):289-302. Unique Identifier : AIDSLINE MED/99229457; Cornilescu G; Delaglio F; Bax A; Laboratory of Chemical Physics, National Institute of Diabetes; and Digestive and Kidney Diseases, National Institutes of Health,; Bethesda, MD 20892-0520, USA.; Chemical shifts of backbone atoms in proteins are exquisitely sensitive to local conformation, and homologous proteins show quite similar patterns of secondary chemical shifts. The inverse of this relation is used to search a database for triplets of adjacent residues with secondary chemical shifts and sequence simila
On the role and significance of Fas (Apo-1/CD95) ligand (FasL) expression in immune privileged tissues and cancer cells using multiple myeloma as a model.: Unique Identifier : AIDSLINE MED/99119011; Greil R; Egle A; Villunger A; Our knowledge in immunology has been dramatically increased by several excellent investigations elucidating the role of the Fas (Apo-1/CD95) receptor/ligand (FasL) system in complex immunological processes such as the acquisition of self tolerance in T cells, progression of autoimmunity, clonal deletion of activated T
Advances in antiviral therapy.: Curr Opin Pediatr. 1999 Feb;11(1):21-7. Unique Identifier : AIDSLINE MED/99183825; Zerr DM; Frenkel LM; Department of Pediatrics, University of Washington, Children's; Hospital and Regional Medical Center, Seattle 98105, USA.; Multiple agents for the treatment and prevention of viral illnesses have been developed during the past few years. While in many cases this has been in direct response to the human immunodeficiency virus type 1 epidemic, a number of new antiviral agents are relevant to the practice of general pediatrics. This article
HIV.: Curr Biol. 1999 Apr 8;9(7):R234. Unique Identifier : AIDSLINE MED/99227361; McKnight A; Molecular Pathology Department, Windeyer Institute of Medical; Sciences,46 Cleveland Street, London W1P 6DB, UK.
HIV: The deadly passenger in dendritic cells.: Curr Biol. 1999 Apr 8;9(7):R248-50. Unique Identifier : AIDSLINE MED/99227366; Rowland-Jones SL; Human Immunology Unit, Institute of Molecular Medicine, John; Radcliffe Hospital, Headington, Oxford OX3 9DS, UK.; A picture is emerging of how HIV subverts a normal immunological surveillance mechanism to establish primary infection. This involves the infection of dendritic cells at mucosal surfaces: as these cells then mature, they transport the virus to lymphoid tissue, where viral replication begins and infection of CD4(+) T c
HIV infection of fetal human astrocytes: the potential role of a receptor-mediated endocytic pathway.: Brain Res. 1999 Mar 27;823(1-2):24-32. Unique Identifier : AIDSLINE MED/99196794; Hao HN; Lyman WD; Department of Pediatrics, Wayne State University School of; Medicine, Detroit, MI 48201, USA.; HIV infects microglia and astrocytes both in vivo and in vitro. Although there is a significant amount of information about microglial infection, data regarding astrocytes are more limited. For example, little is known about the initial membrane events occurring between HIV and astrocytes. Also, the mechanism by which
The 3rd National AIDS Malignancy Conference. Bethesda, Maryland, USA. May 26-27, 1999. Abstracts.: J Acquir Immune Defic Syndr Hum Retrovirol. 1999 May 1;21(1):A1-41. Unique Identifier : AIDSLINE MED/99256614
Isolation and transduction of CD34+ cells from small quantities of peripheral blood from HIV-1-infected patients not treated with hemopoietic growth factors.: J Acquir Immune Defic Syndr Hum Retrovirol. 1999 May 1;21(1):1-8. Unique Identifier : AIDSLINE MED/99249587; Adams GB; McMullen M; Turner S; Olszak IT; Scadden DT; McClure MO; Poznansky MC; Department of Genito-Urinary Medicine and Communicable Diseases,; Jefferiss Research Trust Laboratories, Imperial College School of; Medicine at St. Mary's, London, UK.; A proposed hemopoietic stem cell gene therapy for treatment for HIV infection would involve transduction of CD34+ hemopoietic stem cells with vectors encoding anti-HIV constructs. Peripheral blood has proved to be a useful source of these hemopoietic stem cells and this study exploits this finding. Small quantities of
Role of protease inhibitors in preventing recurrent oral candidosis in patients with HIV infection: a prospective case-control study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1999 May 1;21(1):20-5. Unique Identifier : AIDSLINE MED/99249589; Cauda R; Tacconelli E; Tumbarello M; Morace G; De Bernardis F; Torosantucci A; Cassone A; Department of Infectious Diseases, Catholic University, Rome,; Italy.; This study was conducted to evaluate the efficacy of highly active anti-retroviral therapy (HAART) in preventing recurrence of oral candidosis (OC) associated with HIV. A prospective case-controlled observational study was performed in an inner-city university-hospital HIV/AIDS clinic. Ninety-three HIV-positive study
Escalating multiple-dose safety and tolerance study of oral WR 6026 in HIV-infected subjects: AIDS clinical trials group 173.: J Acquir Immune Defic Syndr Hum Retrovirol. 1999 May 1;21(1):26-32. Unique Identifier : AIDSLINE MED/99249590; Petty BG; Black JR; Hendrix CW; Lewis LD; Basiakos Y; Feinberg J; Pattison DG; Hafner R; The Division of Clinical Pharmacology, Johns Hopkins University; School of Medicine, Baltimore, Maryland, USA.; WR 6026 is an 8-aminoquinoline with activity against Pneumocystis carinii in vitro and in an animal model of P. carinii pneumonia that has predicted the clinical utility of related compounds. This study was conducted to assess the safety and tolerance of WR 6026 given once daily for 21 days to HIV-infected subjects wi
Prevalence and predictors of squamous cell abnormalities in Papanicolaou smears from women infected with HIV-1. Women's Interagency HIV Study Group.: Unique Identifier : AIDSLINE MED/99249591; Massad LS; Riester KA; Anastos KM; Fruchter RG; Palefsky JM; Burk RD; Burns D; Greenblatt RM; Muderspach LI; Miotti P; Department of Obstetrics and Gynecology, Cook County Hospital and; Rush Medical College, Chicago, Illinois, USA.; lsmassad@ameritech.net; BACKGROUND: Cervical neoplasia occurs with increased frequency among women infected with HIV-1. OBJECTIVE: To characterize prevalence of and risk factors for abnormal cervical cytology among women with HIV and to compare them to uninfected women. METHODS: Baseline cervical cytology was obtained from 1713 women seropos
Estimated HIV risk among Hispanics in a national sample of drug users.: J Acquir Immune Defic Syndr Hum Retrovirol. 1999 May 1;21(1):42-50. Unique Identifier : AIDSLINE MED/99249592; Montoya ID; Bell DC; Richard AJ; Carlson JW; Trevino RA; Affiliated Systems Corporation, Houston, Texas, USA.; asc@phoenix.net; OBJECTIVE: To estimate and compare the HIV risks among three Hispanic subpopulations. METHODS: Chronic drug users participating in a nationwide intervention study on drug use were interviewed with regard to drug use and sexual behavior. HIV risk was estimated using information about individuals HIV-relevant behaviors
Risk of HIV infection in oral contraceptive pill users: a meta-analysis.: J Acquir Immune Defic Syndr Hum Retrovirol. 1999 May 1;21(1):51-8. Unique Identifier : AIDSLINE MED/99249593; Wang CC; Kreiss JK; Reilly M; Department of Medicine, University of Washington, Seattle; 98104-2499, USA. chiaw@u.washington.edu; OBJECTIVE: To review the literature and present a summary estimate of the association between HIV-1 acquisition or HIV-1 serostatus and oral contraceptives. DATA SOURCES: MEDLINE database (January 1986-October 1997), AIDSLINE database (January 1980-October 1997), bibliographies of identified articles, and experts in t
Declining HIV/AIDS mortality in New York City.: J Acquir Immune Defic Syndr Hum Retrovirol. 1999 May 1;21(1):59-64. Unique Identifier : AIDSLINE MED/99249594; Chiasson MA; Berenson L; Li W; Schwartz S; Singh T; Forlenza S; Mojica BA; Hamburg MA; Division of Disease Intervention, New York City Department of; Health, New York 10013, USA.; BACKGROUND: New York City has only 3% of the U.S. population but has reported nearly 16% of all AIDS cases. METHODS: This is an observational study using the New York City vital events and AIDS case surveillance registries to describe trends in HIV/AIDS mortality from 1983 through June 30, 1998. RESULTS: Annual HIV/AI
Adult T-cell leukemia/lymphoma in northeastern Brazil: a clinical, histopathologic, and molecular study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1999 May 1;21(1):65-71. Unique Identifier : AIDSLINE MED/99249595; Barbosa HS; Bittencourt AL; Barreto de Araujo I; Pereira Filho CS; Furlan R; Pedrosa C; Lessa G; Harrington W Jr; Galvao Castro B; Department of Pathology, School of Medicine, Federal University; of Bahia, Brazil. hschaer@svn.com.br; The state of Bahia in the northeastern coast of Brazil is a region in which HTLV-I infection is endemic. This study investigated the characteristics of 28 HTLV-I-associated lymphomas/leukemias in this region. HTLV-I-infection diagnosis was based on serologic study, Southern blot an
HIV-1 reactivation in resting peripheral blood mononuclear cells of infected adults upon in vitro CD4 cross-linking by ligands of the CDR2-loop in extracellular domain 1.: J Acquir Immune Defic Syndr Hum Retrovirol. 1999 May 1;21(1):9-19. Unique Identifier : AIDSLINE MED/99249588; Briant L; Reynes J; Coudronniere N; Benezech JP; Devaux C; Laboratoire Infections Retrovirales et Signalisation Cellulaire,; CRBM-CRNS UPR 1086, Institut de Biologie, Montpellier, France.; briant@crbm.cnrs-mop.fr; HIV-1 infects resting peripheral blood mononuclear cells (PBMCs) but remains inactive state until subsequent cell activation. We have demonstrated that the cross-linking of cell surface CD4 by gp120-anti-gp120 immune complexes or heat-inactivated HIV-1 (iHIV-1) is sufficient to trigger activation signals leading to vi
Selected pediatric viral infections.: Semin Pediatr Neurol. 1995 Sep;2(3):211-9. Unique Identifier : AIDSLINE MED/98084272; Powell S; Schochet SS Jr; Department of Pathology, University of Florida College of; Medicine, J. Hillis Miller Health Sciences Center, Gainesville,; USA.; Viral infections of the central nervous system in infants and children are uncommon but potentially serious illnesses. Common causes have included the enteroviruses (particularly polioviruses and coxsackieviruses), herpes viruses (type 1 and type 2 herpes simplex, varicella, and cytome
The CXC-chemokine, H174: expression in the central nervous system.: J Neurovirol. 1998 Dec;4(6):575-85. Unique Identifier : AIDSLINE GENBANK/AF002985; Luo Y; Kim R; Gabuzda D; Mi S; Collins-Racie LA; Lu Z; Jacobs KA; Dorf ME; Department of Pathology, Harvard Medical School, Boston,; Massachusetts 02115, USA.; H174 is a new member of the CXC-chemokine family. A cDNA probe containing the entire H174 coding region recognized a predominant inducible transcript of approximately 1.5 kb expressed in interferon (IFN) activated astrocytoma and monocytic cell lines. H174 message can be induced following IFN-alpha, IFN-beta, or IFN-g
Analysis of HTLV-I proviral load in 202 HAM/TSP patients and 243 asymptomatic HTLV-I carriers: high proviral load strongly predisposes to HAM/TSP.: J Neurovirol. 1998 Dec;4(6):586-93. Unique Identifier : AIDSLINE MED/99163783; Nagai M; Usuku K; Matsumoto W; Kodama D; Takenouchi N; Moritoyo T; Hashiguchi S; Ichinose M; Bangham CR; Izumo S; Osame M; Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima; University, Japan.; In order to examine the effect of HTLV-I proviral load on the pathogenesis of HAM/TSP, we measured the HTLV-I proviral load in peripheral blood mononuclear cells (PBMC) from a large number of HAM/TSP patients and asymptomatic HTLV-I carriers. To measure the proviral load, we used an accurate and reproducible quantitat
Cocaine opens the blood-brain barrier to HIV-1 invasion.: J Neurovirol. 1998 Dec;4(6):619-26. Unique Identifier : AIDSLINE MED/99163786; Zhang L; Looney D; Taub D; Chang SL; Way D; Witte MH; Graves MC; Fiala M; Department of Neurology, UCLA School of Medicine, Los Angeles,; California 90095-1769, USA.; Cocaine abuse has been associated with vasculitis and stroke, and is suspected to influence the progression of AIDS dementia . Cocaine may enhance HIV-1 neuroinvasion by actions directed at the blood-brain barrier. HIV-1 appears to penetrate the human brain microvascular endothelial
Emerging infectious diseases--United Kingdom.: Emerg Infect Dis. 1999 Mar-Apr;5(2):189-94. Unique Identifier : AIDSLINE MED/99238844; Walford D; Noah N; Public Health Laboratory Service, London, United Kingdom.
Evaluating diagnosis and treatment of oral and esophageal candidiasis in Ugandan AIDS patients.: Emerg Infect Dis. 1999 Mar-Apr;5(2):274-7. Unique Identifier : AIDSLINE MED/99238857; Ravera M; Reggiori A; Agliata AM; Rocco RP; Regional Teaching Hospital, Hoima, Uganda. petra@swiftuganda.com; A randomized cross-over clinical and endoscopic evaluation of 85 Ugandan patients showed that esophageal candidiasis in AIDS patients with oral candidiasis could be managed without endoscopy and biopsies. Oral lesions, especially when accompanied by esophageal symptoms, were sufficient for diagnosis. Miconazole was mo
Single daily doses of saquinavir achieve HIV-inhibitory concentrations when combined with baby-dose ritonavir.: Eur J Med Res. 1999 Mar 26;4(3):101-4. Unique Identifier : AIDSLINE MED/99187394; Kurowski M; Muller M; Donath F; Mrozikiewicz M; Mocklinghoff C; HIV-LAB Berlin, c/o Auguste-Viktoria Krankenhaus, Rubensstr. 125,; D-12157 Berlin, Germany. labor-kurowski@t-online.de; Dual protease inhibitor (PI) therapy has been established either in order to increase plasma concentrations of one PI or to combine synergistic effects of two PI s on viral load. Studies with saquinavir (SQV) and small doses of ritonavir (RTV) as well
Cases of HIV-associated characteristic periodontal diseases.: Eur J Med Res. 1999 Mar 26;4(3):121-5. Unique Identifier : AIDSLINE MED/99187398; Pistorius A; Willershausen B; Poliklinik fur Zahnerhaltungskunde und Parodontologie,; Augustusplatz 2, D-55131 Mainz,; Germany.willersh@mail.uni-mainz.de; In the course of infection by the Human Immunodeficiency Virus (HIV) typical changes of inflammatory periodontal diseases can arise. The prevalence of these illnesses may be up to 5%. The HIV-associated periodontal diseases include linear gingival erythema (LGE), necrotizing ulcerative gingivitis (NUG) and necrotizing
Cytokine profile of HIV-positive Kaposi's sarcoma derived cells in vitro.: Eur J Med Res. 1999 Mar 26;4(3):95-100. Unique Identifier : AIDSLINE MED/99187393; Brockmeyer NH; Willers CP; Anders S; Mertins L; Rockstroh JK; Sturzl M; Ruhr Universitat Bochum, Department of Dermatology, St.; Josef-Hospital, Gudrunstr. 56, D-44791 Bochum, Germany.; N.Brockmeyer@derma.de; Kaposi s sarcoma (KS) is the most frequent neoplastic complication observed in HIV-infected patients. Cutaneous KS is the most common manifestation but visceral and lymph node involvement may occur. HIV-infection does not only lead to a decrease of certain cell types (CD4 T-lymphocytes), but also modifies the function
Apoptosis induced by crosslinking of CD4 on activated human B cells.: Cell Immunol. 1999 Apr 10;193(1):80-9. Unique Identifier : AIDSLINE MED/99219847; Cutrona G; Leanza N; Ulivi M; Majolini MB; Taborelli G; Zupo S; Baldari CT; Roncella S; Ferrarini M; Istituto Nazionale per la Ricerca sul Cancro, IST-Servizio di; Immunologia Clinica, Genoa, 16132, Italy.; Using immunofluorescence, RT-PCR, and Western blotting, we have demonstrated the ability of human B cells to express CD4. In each of the 10 lymphoblastoid cell lines (LCL) tested there was variable, but definite, proportion of CD4-positive B cells. Expression of CD4 was related to the cell cycle; CD4 was expressed in
Stem cell directed gene therapy.: Unique Identifier : AIDSLINE MED/99248355; Engel BC; Kohn DB; A potential therapeutic approach to HIV-1 infection is the genetic modification of cells of a patient to make them resistant to HIV-1. Hematopoietic stem cells are an attractive target for gene therapy of AIDS because of their ability to generate a broad repertoire of mature T lymphocytes, as well as the monocytic cel
Human immunodeficiency virus and the hematopoietic repertoire: implications for gene therapy.: Front Biosci. 1999 May 1;4:D457-67. Unique Identifier : AIDSLINE MED/99248354; Panoskaltsis N; Abboud CN; University of Rochester Medical Center, Hematology/Oncology Unit,; 601 Elmwood Ave, Box 610, Rochester, NY 14642, USA.; The human immunodeficiency virus (HIV) infects primarily the hematopoietic and immune systems. At the onset of infection, an initial activation of the immune system occurs, with a subsequent suppression thereafter due to direct viral infection of cells, inhibitory effects of HIV proteins, an altered microenvironment w
Tip60 acetylates six lysines of a specific class in core histones in vitro.: Genes Cells. 1998 Dec;3(12):789-800. Unique Identifier : AIDSLINE MED/99195754; Kimura A; Horikoshi M; Department of Cellular Biology, University of Tokyo, Japan.; BACKGROUND: Tip60, an HIV-1-Tat interactive protein, is a nuclear histone acetyltransferase (HAT) with unique histone substrate specificity. Since the acetylation of core histones at particular lysines mediates distinct effects on chromatin assembly and gene regulation, the identification of lysine site specificity of
A phase I vaccine trial with peptides reflecting ras oncogene mutations of solid tumors.: Unique Identifier : AIDSLINE MED/99193000; Khleif SN; Abrams SI; Hamilton JM; Bergmann-Leitner E; Chen A; Bastian A; Bernstein S; Chung Y; Allegra CJ; Schlom J; Mutations in the ras genes occur in 20% of all human cancers. These genes, in turn, produce mutated proteins that are unique to cancer cells, rendering them distinguishable from normal cells by the immune system. Thus, mutated Ras proteins may form potential targets for immune therapy. We conducted a phase I/pilot cli
Managing and treating. AIDS-related diarrhea.: Adv Nurse Pract. 1998 Jul;6(7):55-6, 58-60. Unique Identifier : AIDSLINE MED/98456120; Tetreault D; Chang E; Harbor-UCLA Medical Center Division of Allergy & Clinical; Immunology, Torrance, USA.; Diarrhea is a significant problem for most people with AIDS. Its causes are multifactorial, ranging from infectious organisms to malignancies and functional problems. A thorough evaluation will usually determine the etiology and guide treatment. With HAART, dramatic improvements in immune status have caused a decline
Phase inversion dynamics of PLGA solutions related to drug delivery.: J Controlled Release. 1999 Mar 29;58(2):233-45. Unique Identifier : AIDSLINE MED/99164279; Graham PD; Brodbeck KJ; McHugh AJ; Department of Chemical Engineering, University of Illinois, 600; S. Mathews, Urbana, IL 61801, USA.; Dark ground optical microscopy, electron microscopy, and high performance liquid chromatography (HPLC) have been used to quantify the effects of formulation changes on the phase inversion dynamics and in vitro drug release properties of a PLGA-based drug delivery system. Gel growth rates and water influx rates are det
Safer sex strategies for women: the hierarchical model in methadone treatment clinics.: J Urban Health. 1999 Mar;76(1):62-72. Unique Identifier : AIDSLINE MED/99191291; Stein Z; Saez H; el-Sadr W; Healton C; Mannheimer S; Messeri P; Scimeca MM; Van Devanter N; Zimmerman R; Betne P; Division of Epidemiology, Joseph L. Mailman School of Public; Health of Columbia University, New York, NY 10032, USA.; zas2@columbia.edu; Women clients of a methadone maintenance treatment clinic were targeted for an intervention aimed to reduce unsafe sex. The hierarchical model was the basis of the single intervention session, tested among 63 volunteers. This model requires the educator to discuss and demonstrate a full range of barriers that women mi
Inhibitory effects of Sudanese plant extracts on HIV-1 replication and HIV-1 protease.: Phytother Res. 1999 Feb;13(1):31-6. Unique Identifier : AIDSLINE MED/99205945; Hussein G; Miyashiro H; Nakamura N; Hattori M; Kawahata T; Otake T; Kakiuchi N; Shimotohno K; Research Institute for Wakan-Yaku (Traditional Sino-Japanese; Medicines), Toyama Medical and Pharmaceutical University, Japan.; Forty-eight methanol and aqueous extracts from Sudanese plants were screened for their inhibitory activity on viral replication. Nineteen extracts showed inhibitory effects on HIV-induced cytopathic effects (CPE) on MT-4 cells. The extracts were further screened against HIV-1 protease (PR) using an HPLC assay method.
Anti-CD95 (APO-1/Fas) autoantibodies and T cell depletion in human immunodeficiency virus type 1 (HIV-1)-infected children.: Cell Death Differ. 1998 Mar;5(3):222-30. Unique Identifier : AIDSLINE MED/99218579; Stricker K; Knipping E; Bohler T; Benner A; Krammer PH; Debatin KM; Haematology/Oncology, University Children's Hospital and Division; of Molecular Oncology, German Cancer Research Center, Heidelberg,; Germany.; Advanced stages of HIV-1-infection are characterized by progressive CD4+ T cell depletion. Peripheral T cells from HIV-1+ donors show accelerated apoptosis in vitro. The CD95 (APO-1/Fas) receptor/ligand system is involved in this process. To further study deregulation of the CD95 system in peripheral T cells during HI
Selective killing of CD8+ cells with a 'memory' phenotype (CD62Llo) by the N-acetyl-D-galactosamine-specific lectin from Viscum album L.: Cell Death Differ. 1998 Mar;5(3):231-40. Unique Identifier : AIDSLINE MED/99218580; Bussing A; Stein GM; Pfuller U; Krebsforschung Herdecke, Department of Applied Immunology,; Communal Hospital Herdecke, D-58313 Herdecke, Germany.; ArBuess@t-online.de; As reported previously by our group, among the toxic proteins from Viscum album L. only the mistletoe lectins (MLs) induce the apoptotic killing pathway in human lymphocytes. Although one may expect a homogenous distribution of carbohydrate domains on cell surface receptors for the carbohydrate binding B chains of the
Substituted 7H-pyrido[4,3-c]carbazoles with potent anti-HIV activity.: Unique Identifier : AIDSLINE MED/99145937; Hirata K; Ito C
In vivo anti-HIV activity of (+)-calanolide A in the hollow fiber mouse model.: Bioorg Med Chem Lett. 1999 Jan 18;9(2):133-8. Unique Identifier : AIDSLINE MED/99145940; Xu ZQ; Hollingshead MG; Borgel S; Elder C; Khilevich A; Flavin MT; MediChem Research, Inc., Lemont, IL, USA.; In vivo anti-HIV efficacy of (+)-calanolide A has been evaluated in a hollow fiber mouse model. It was demonstrated that the compound was capable of suppressing virus replication in two distinct and separate physiologic compartments (i.p. and s.c.) following oral or parenteral administration on a once- or twice-daily
Photoactivated virucidal properties of tridentate 2,2'-dihydroxyazobenzene and 2-salicylideneaminophenol platinum pyridine complexes.: Bioorg Med Chem Lett. 1999 Jan 18;9(2):237-40. Unique Identifier : AIDSLINE MED/99145962; Cuny GD; Landgrebe KD; Smith TP; Fehr MJ; Petrich JW; Carpenter S; 3M Center, St. Paul, MN 55144-1000, USA.; The potent photoactivated virucidal activity of tridentate 2,2 -dihydroxyazobenzene- and 2-salicylideneaminophenol platinum pyridine complexes 1, 2, 4, 6, 7, 9, and 10 against enveloped viruses (e.g., EIAV, HIV, and HSV) is described.
Cytomegaloviral enterocolitis: clinical associations and outcome.: Dis Colon Rectum. 1999 Jan;42(1):24-30. Unique Identifier : AIDSLINE MED/99226498; Kaufman HS; Kahn AC; Iacobuzio-Donahue C; Talamini MA; Lillemoe KD; Hamilton SR; Department of Surgery, The Johns Hopkins Medical Institutions,; Baltimore, Maryland, USA.; PURPOSE: Cytomegaloviral enterocolitis is an uncommon disorder that can complicate inflammatory bowel disease. It is more common in patients with acquired immunodeficiency syndrome and can occur in patients on immunosuppressive therapy for autoimmune or inflammatory diseases and in allograft recipients. Mortality rate
T-cell receptor gene usage in patients with fibrosing alveolitis and control subjects.: Eur J Clin Invest. 1999 Feb;29(2):173-81. Unique Identifier : AIDSLINE MED/99192965; Lympany PA; Southcott AM; Welsh KI; Black CM; Boylston AW; du Bois RM; Imperial College of Science, Technology and Medicine, London, UK.; BACKGROUND: Fibrosing alveolitis is characterized by inflammation, fibrosis and increased numbers of activated CD4+ T-cells in the lower respiratory tract. The aims of this study were to compare the T-cell antigen receptor repertoire in the lungs of subjects with fibrosing alveolitis systemic sclerosis (FASSc) with cr
Changing patterns of dominance in the CD8+ T cell response during acute and persistent murine gamma-herpesvirus infection.: Eur J Immunol. 1999 Apr;29(4):1059-67. Unique Identifier : AIDSLINE MED/99244077; Stevenson PG; Belz GT; Altman JD; Doherty PC; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, TN 38105, USA.; The murine gamma-herpesvirus MHV-68 causes an acute, transient pneumonitis, followed by an infectious mononucleosis (IM)-like illness with splenomegaly, widespread latent infection of B lymphocytes and an expansion of Vbeta4+ CD8+ T cells. CD8+ T cells specific for an H-2Db-restricted epitope were prominent during the
Differential regulation of killer cell Ig-like receptors and CD94 lectin-like dimers on NK and T lymphocytes from HIV-1-infected individuals.: Eur J Immunol. 1999 Apr;29(4):1076-85. Unique Identifier : AIDSLINE MED/99244079; Andre P; Brunet C; Guia S; Gallais H; Sampol J; Vivier E; Dignat-George F; Centre d'Immunologie INSERM/CNRS de Marseille-Luminy, Marseille,; France.; NK and T lymphocytes share various cell surface receptors, including NK receptors for MHC class I molecules (NKR). NKR include killer cell Ig-like receptors (KIR) and lectin-like dimers which are composed of the invariant CD94 associated with a variety of NKG2 molecules. The combination of KIR and CD94/NKG2 dimers exp
Systemic T cell expansion during localized viral infection.: Eur J Immunol. 1999 Apr;29(4):1168-74. Unique Identifier : AIDSLINE MED/99244089; Haanen JB; Toebes M; Cordaro TA; Wolkers MC; Kruisbeek AM; Schumacher TN; Division of Immunology, The Netherlands Cancer Institute,; Amsterdam.; In a local immune response, the priming and expansion of the antigen-specific T cell population has been thought to largely take place in the draining lymphoid tissue. This model was primarily based on indirect enumeration of antigen-specific T cells by limiting dilution analyses. Here, tetrameric MHC class I complexe
Human intestinal lamina propria lymphocytes are naturally permissive to HIV-1 infection.: Eur J Immunol. 1999 Apr;29(4):1202-8. Unique Identifier : AIDSLINE MED/99244093; Lapenta C; Boirivant M; Marini M; Santini SM; Logozzi M; Viora M; Belardelli F; Fais S; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.; The presence of HIV-1 in the intestinal mucosa of AIDS patients has been reported and human intestinal lamina propria lymphocytes (LPL) have been proposed as important targets for HIV-1 infection. However, little information is available concerning the permissiveness of human intestinal CD4+ T lymphocytes to HIV-1 inf
Single H2Kb, H2Db and double H2KbDb knockout mice: peripheral CD8+ T cell repertoire and anti-lymphocytic choriomeningitis virus cytolytic responses.: Eur J Immunol. 1999 Apr;29(4):1243-52. Unique Identifier : AIDSLINE MED/99244098; Perarnau B; Saron MF; San Martin BR; Bervas N; Ong H; Soloski MJ; Smith AG; Ure JM; Gairin JE; Lemonnier FA; Departement SIDA-Retrovirus, Institut Pasteur, Paris, France.; perarnau@pasteur.fr; Single H2Kb, H2Db and double H2KbDb homozygous knockout (KO) mice were generated and their peripheral CD8+ T cell repertoires compared to that of C57BL/6 (B6) mice. Limited (10-20%, H2Db), substantial (30-50%, H2Kb) and profound (90%, H2KbDb) reduction of peripheral CD8+ T cells was observed in KO mice, without Vbeta
The role of IL-4 in the staphylococcal enterotoxin B-triggered immune response: increased susceptibility to shock and deletion of CD8Vbeta8+ T cells in IL-4 knockout mice.: Eur J Immunol. 1999 Apr;29(4):1397-405. Unique Identifier : AIDSLINE MED/99244114; Aroeira LS; Martinez-A C; Department of Immunology and Oncology, Centro Nacional de; Biotecnologia, CSIC, Universidad Autonoma de Madrid, Spain.; laroeira@net.ipen.br; Administration of superantigens in vivo triggers responding T cells into clonal expansion and subsequent activation of the programmed cell death pathway, as well as into anergy. We examined the possibility that Th1 cytokines are involved in rescue from superantigen-induced programmed cell death and prevention of anerg
Influence of ovarian stimulation on the detection of human papillomavirus DNA in cervical scrapes obtained from patients undergoing assisted reproductive techniques.: Fertil Steril. 1999 May;71(5):815-20. Unique Identifier : AIDSLINE MED/99246069; Strehler E; Sterzik K; Malthaner D; Hoyer H; Nindl I; Schneider A; Institute for Reproductive Medicine, Ulm, Germany.; OBJECTIVE: To determine whether gonadotropin stimulation influences the detection of human papillomavirus (HPV) DNA in cervical scrapes. DESIGN: Prospective, controlled study. SETTING: Tertiary care infertility clinic. PATIENT(S): Two hundred ninety-four patients enrolled in an IVF or IUI program. Two thousand two hun
Flow cytometric evaluation of lymphocyte subpopulations in BALF of healthy smokers and nonsmokers.: Folia Histochem Cytobiol. 1999;37(1):25-30. Unique Identifier : AIDSLINE MED/99190368; Hoser G; Kawiak J; Domagala-Kulawik J; Kopinski P; Droszcz W; Department of Clinical Cytology, Medical Centre of Postgraduate; Education, Warsaw, Poland.; The purpose of this work was to evaluate the normal lymphocyte phenotype in the bronchoalveolar lavage fluid (BALF). BAL was carried out in 12 untreated healthy nonsmoking volunteers and in 9 cigarette smokers. For the analysis of lymphocyte subsets by two-color flow cytometry, the monoclonal antibodies used were dire
[Help your patient to correctly evaluate diagnosis and risk]: Fortschr Med. 1999 Mar 30;117(9):38. Unique Identifier : AIDSLINE MED/99248779
Drug watch [news]: Indian Pediatr. 1998 Dec;35(12):1256. Unique Identifier : AIDSLINE MED/99232359
Modeling of the interaction between new ethidium derivatives and TAR RNA of HIV-1.: J Chem Inf Comput Sci. 1999 Mar-Apr;39(2):413-9. Unique Identifier : AIDSLINE MED/99209031; Terreux R; Cabrol-Bass D; Peytou V; Condom R; Guedj R; GRECFO-Equipe LARTIC, Universite de Nice Sophia Antipolis,; France.; During the HIV-1 replication process, interactions between the first sequence of RNA synthesized named TAR RNA and a viral protein named Tat permit a fast and efficient transcription of viral DNA in RNA. Based on the NMR structure of TAR RNA found on the PDB, new derivatives of ethidium were designed by molecular mode
Highly sensitive methods for quantitation of human immunodeficiency virus type 1 RNA from plasma, cells, and tissues.: J Clin Microbiol. 1999 May;37(5):1260-4. Unique Identifier : AIDSLINE MED/99221734; Fischer M; Huber W; Kallivroussis A; Ott P; Opravil M; Luthy R; Weber R; Cone RW; Division of Infectious Diseases and Hospital Epidemiology,; Department of Medicine, University Hospital Zurich, CH-8091; Zurich, Switzerland. inffia@usz.unizh.ch; Precise and sensitive quantitation of viral RNA in specimens from human immunodeficiency virus (HIV) type 1 (HIV-1)-infected individuals has become an indispensable tool for the monitoring of the efficacy of highly active antiretroviral combination therapy . The present
Multicenter comparison of PCR assays for detection of human herpesvirus 8 DNA in semen.: J Clin Microbiol. 1999 May;37(5):1298-301. Unique Identifier : AIDSLINE MED/99221741; Pellett PE; Spira TJ; Bagasra O; Boshoff C; Corey L; de Lellis L; Huang ML; Lin JC; Matthews S; Monini P; Rimessi P; Sosa C; Wood C; Stewart JA; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA. php1@cdc.gov; Reported prevalences of human herpesvirus 8 (HHV-8) (Kaposi s sarcoma-associated herpesvirus) in semen have ranged widely. This is possibly due to differences in assay sensitivity, geographic or population-based differences in the true presence of the virus in semen, and PCR contamination. This study assessed interlab
Evaluation of the INNO-LIA HTLV I/II assay for confirmation of human T-cell leukemia virus-reactive sera in blood bank donations.: J Clin Microbiol. 1999 May;37(5):1324-8. Unique Identifier : AIDSLINE MED/99221746; Sabino EC; Zrein M; Taborda CP; Otani MM; Ribeiro-Dos-Santos G; Saez-Alquezar A; Fundacao Pro-Sangue, Sao Paulo, Brazil. sabinoec@usp.br; We have evaluated a new serological confirmatory test (INNO-LIA HTLV I/II Ab [INNO-LIA]) for human T-cell leukemia virus (HTLV) using a large collection of samples from Brazilian blood donors (Sao Paulo region) and compared the results with those obtained by Western blotting (WB) tests (WB2.3 and WB2.4). Blood donatio
Discrimination of subtype B and non-subtype B strains of human immunodeficiency virus type 1 by serotyping: correlation with genotyping.: J Clin Microbiol. 1999 May;37(5):1356-60. Unique Identifier : AIDSLINE MED/99221753; Murphy G; Belda FJ; Pau CP; Clewley JP; Parry JV; Hepatitis and Retrovirus Laboratory, PHLS Virus Reference; Division, Central Public Health Laboratory, Colindale, London NW9; 5HT, United Kingdom.; The ability of a peptide-based serotyping assay to differentiate human immunodeficiency virus (HIV) type 1 (HIV-1) subtype B infections from non-subtype B infections was investigated with 166 anti-HIV-1- and HIV RNA-positive (by PCR) serum or plasma specimens. The specimens were divided genetically into those infected
High aspartyl proteinase production and vaginitis in human immunodeficiency virus-infected women.: J Clin Microbiol. 1999 May;37(5):1376-80. Unique Identifier : AIDSLINE MED/99221757; de Bernardis F; Mondello F; Scaravelli G; Pachi A; Girolamo A; Agatensi L; Cassone A; Department of Bacteriology and Medical Mycology, Istituto; Superiore di Sanita, Rome, Italy.; Vaginal isolates of Candida albicans from human immunodeficiency virus-positive (HIV+) and HIV- women with or without candidal vaginitis were examined for secretory aspartyl proteinase (Sap) production in vitro and in vivo and for the possible correlation of Sap production with pathology and antimycotic susceptibility
Relatedness analyses of Histoplasma capsulatum isolates from Mexican patients with AIDS-associated histoplasmosis by using histoplasmin electrophoretic profiles and randomly amplified polymorphic DNA patterns.: J Clin Microbiol. 1999 May;37(5):1404-8. Unique Identifier : AIDSLINE MED/99221762; Reyes-Montes MR; Bobadilla-Del Valle M; Martinez-Rivera MA; Rodriguez-Arellanes G; Maravilla E; Sifuentes-Osornio J; Taylor ML; Departamento de Microbiologia-Parasitologia, Facultad de; Medicina, UNAM, Mexico City, Mexico.; The present paper analyzes the histoplasmin electrophoretic profiles and the randomly amplified polymorphic DNA (RAPD) patterns of the fungus Histoplasma capsulatum isolated from Mexican patients with AIDS-associated histoplasmosis. Clinical isolates from Guatemala ,
Coaggregation of Candida dubliniensis with Fusobacterium nucleatum.: J Clin Microbiol. 1999 May;37(5):1464-8. Unique Identifier : AIDSLINE MED/99221773; Jabra-Rizk MA; Falkler WA Jr; Merz WG; Kelley JI; Baqui AA; Meiller TF; Department of Oral Medicine, Dental School, University of; Maryland, Baltimore, 21201, USA. mrizk@umaryland.edu; The binding of microorganisms to each other and oral surfaces contributes to the progression of microbial infections in the oral cavity. Candida dubliniensis, a newly characterized species, has been identified in human immunodeficiency virus-seropositive patients and other immunocompromised individuals. C. dubliniensi
Mycoplasma penetrans and other mycoplasmas in urine of human immunodeficiency virus-positive children.: J Clin Microbiol. 1999 May;37(5):1518-23. Unique Identifier : AIDSLINE MED/99221782; Hussain AI; Robson WL; Kelley R; Reid T; Gangemi JD; Department of Microbiology and Molecular Medicine, Clemson; University, Clemson, South Carolina.; Urine samples from children with human immunodeficiency virus (HIV) infection and healthy controls were examined for mycoplasmas by culture. Standard biochemical assays, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and PCR (16S and 16S-23S spacer rRNA region) were used for identification of isolates. Myc
Comparison of human immunodeficiency virus type 1 (HIV-1) protease mutations in HIV-1 genomes detected in plasma and in peripheral blood mononuclear cells from patients receiving combination drug therapy.: J Clin Microbiol. 1999 May;37(5):1595-7. Unique Identifier : AIDSLINE MED/99221799; Koch N; Yahi N; Ariasi F; Fantini J; Tamalet C; Laboratoire de Virologie, CHRU La Timone, 13005 Marseille,; France.; Detections of mutations in the protease gene of human immunodeficiency virus type 1 in plasma and peripheral blood mononuclear cells (PBMC) were sought in two matched populations of 23 individuals receiving combination drug therapy with or without protease inhibitors
IL-7 enhances Ag-specific human T cell response by increasing expression of IL-2R alpha and gamma chains.: Unique Identifier : AIDSLINE MED/99241968; Chou YK; Bourdette DN; Barnes D; Finn TP; Murray S; Unsicker L; Robey I; Whitham RH; Buenafe AC; Allegretta M; Offner H; Vandenbark AA; Veterans Affairs Medical Center, Department of Neurology, Oregon; Health Sciences University, Portland 97201, USA. barnesd@ohsu.edu; Interleukin-7 has demonstrated potent enhancing effects on the growth and differentiation of several immature cell types, including thymocytes, and on survival of resting and antigen activated T cells. In this study, we evaluated the effects of IL-7 on post-thymic antigen-specific T cells from human blood. IL-7 was fo
Cytokine expression in the rat central nervous system following perinatal Borna disease virus infection.: J Neuroimmunol. 1999 Apr 1;96(1):29-45. Unique Identifier : AIDSLINE MED/99241961; Sauder C; de la Torre JC; Department of Neuropharmacology, The Scripps Research Institute,; La Jolla, CA 92037, USA.; Borna disease virus (BDV) causes central nervous system (CNS) disease in several vertebrate species, which is frequently accompanied by behavioral abnormalities. In the adult rat, intracerebral (i.c.) BDV infection leads to immunomediated meningoencephalitis. In contrast, i.c. infection of neonates causes a persistent
Distribution of T-lymphocyte subpopulation in blood and spleen of normal cattle and cattle with enzootic bovine leukosis.: J Comp Pathol. 1999 Feb;120(2):117-27. Unique Identifier : AIDSLINE MED/99187450; Wu D; Takahashi K; Liu N; Koguchi A; Makara M; Sasaki J; Goryo M; Okada K; Department of Veterinary Pathology, Faculty of Agriculture, Iwate; University, Morioka, Japan.; Immunocytochemical and flow cytometry techniques were used to examine T-lymphocyte subpopulations in peripheral blood lymphocytes (PBLs) and spleen from cases of enzootic bovine leukosis (EBL) in adult cattle, and from normal cattle (adult and young), with a panel of monoclonal antibodies against bovine leucocyte diff
T-cell-rich B-cell lymphoma in the cat.: J Comp Pathol. 1999 Feb;120(2):155-67. Unique Identifier : AIDSLINE MED/99187453; Day MJ; Kyaw-Tanner M; Silkstone MA; Lucke VM; Robinson WF; Department of Pathology and Microbiology, University of Bristol,; Langford, United Kingdom.; The clinical and pathological features of eight cases of feline T-cell-rich B-cell lymphoma are described. The disease occurred in older cats (mean age 11.4 +/- 3.9 years), which on initial examination generally showed enlargement of a single submandibular or cervical lymph node. After excision, there was no recurrenc
Survival of naive CD4 T cells: roles of restricting versus selecting MHC class II and cytokine milieu.: J Immunol. 1999 Apr 1;162(7):3795-801. Unique Identifier : AIDSLINE MED/99218394; Boursalian TE; Bottomly K; Section of Immunobiology, Yale University School of Medicine,; Howard Hughes Medical Institute, New Haven, CT 06520, USA.; The diversity of naive CD4 T cells plays an important role in the adaptive immune response by ensuring the capability of responding to novel pathogens. In the past, it has been generally accepted that naive CD4 T cells are intrinsically long-lived; however, there have been studies suggesting some CD4 T cells are short
TCR signaling thresholds regulating T cell development and activation are dependent upon SHP-1.: J Immunol. 1999 Apr 1;162(7):3802-13. Unique Identifier : AIDSLINE MED/99218395; Johnson KG; LeRoy FG; Borysiewicz LK; Matthews RJ; Department of Medicine, University of Wales College of Medicine,; Cardiff, United Kingdom.; An examination of thymocytes and peripheral T cells from SHP-1-deficient motheaten mice possessing a transgenic MHC class I-restricted TCR has implicated SHP-1 in regulating TCR signaling thresholds at three checkpoints in T cell development and activation. First, in the population of CD4-CD8- double negative thymocyt
Selection of CD8+ T cells with highly focused specificity during viral persistence in the central nervous system.: J Immunol. 1999 Apr 1;162(7):3905-14. Unique Identifier : AIDSLINE MED/99218407; Marten NW; Stohlman SA; Smith-Begolka W; Miller SD; Dimacali E; Yao Q; Stohl S; Goverman J; Bergmann CC; Department of Neurology, University of Southern California School; of Medicine, Los Angeles 90033, USA.; The relationships between T cell populations during primary viral infection and persistence are poorly understood. Mice infected with the neurotropic JHMV strain of mouse hepatitis virus mount potent regional CTL responses that effectively reduce infectious virus; nevertheless, viral RNA persists in the central nervou
Utilization of MHC class I transgenic mice for development of minigene DNA vaccines encoding multiple HLA-restricted CTL epitopes.: J Immunol. 1999 Apr 1;162(7):3915-25. Unique Identifier : AIDSLINE MED/99218408; Ishioka GY; Fikes J; Hermanson G; Livingston B; Crimi C; Qin M; del Guercio MF; Oseroff C; Dahlberg C; Alexander J; Chesnut RW; Sette A; Epimmune, San Diego, CA 92121, USA. gishioka@epimmune.com; We engineered a multiepitope DNA minigene encoding nine dominant HLA-A2.1- and A11-restricted epitopes from the polymerase, envelope, and core proteins of hepatitis B virus and HIV, together with the PADRE (pan-DR epitope) universal Th cell epitope and an endoplasmic reticulum-translocating signal sequence. Immunizati
Antibodies to the IL-12 receptor beta 2 chain mark human Th1 but not Th2 cells in vitro and in vivo.: J Immunol. 1999 Apr 1;162(7):3926-32. Unique Identifier : AIDSLINE MED/99218409; Rogge L; Papi A; Presky DH; Biffi M; Minetti LJ; Miotto D; Agostini C; Semenzato G; Fabbri LM; Sinigaglia F; Roche Milano Ricerche, Milan, Italy.; Great attention has been placed on the possibility of distinguishing Th1 from Th2 cells on the basis of differential expression of surface receptors. We have recently shown that the differential expression of the IL-12R beta 2 chain in Th1 and Th2 cells, as measured at the mRNA level, accounts for an important regulat
Adjuvant-guided type-1 and type-2 immunity: infectious/noninfectious dichotomy defines the class of response.: J Immunol. 1999 Apr 1;162(7):3942-9. Unique Identifier : AIDSLINE MED/99218411; Yip HC; Karulin AY; Tary-Lehmann M; Hesse MD; Radeke H; Heeger PS; Trezza RP; Heinzel FP; Forsthuber T; Lehmann PV; Department of Pathology, Case Western Reserve University School; of Medicine, Cleveland, OH 44106, USA.; Traditionally, protein Ags have been injected in CFA (oil with inactivated mycobacteria) to induce immunity and with IFA (oil alone) to induce tolerance. We report here that injection of hen eggwhite lysozyme, a prototypic Ag, in CFA-induced and IFA-induced pools of hen eggwhite lysozyme-specific memory T cells of com
Increased generation of CD8+ T cell clones in p53 mutant mice.: J Immunol. 1999 Apr 1;162(7):3957-60. Unique Identifier : AIDSLINE MED/99218413; Zhou X; Wong S; Walter J; Jacks T; Eisen HN; Center for Cancer Research, Department of Biology, Howard Hughes; Medical Institute, Massachusetts Institute of Technology,; Cambridge, MA 02139, USA.; Very few cultured CD8+ T cell clones can normally be obtained from a single mouse and maintained in long-term culture. To improve the yield, we immunized p53 mutant mice with peptides of Sendai virus (FAPGNYPAL) and influenza virus (ASNENMETM) origin. Substantially more clones could be derived from p53-/- mice than fr
CD69 expression discriminates MHC-dependent and -independent stages of thymocyte positive selection.: J Immunol. 1999 Apr 1;162(7):3978-83. Unique Identifier : AIDSLINE MED/99218416; Hare KJ; Jenkinson EJ; Anderson G; Department of Anatomy, University of Birmingham Medical School,; Edgbaston, United Kingdom. k.j.hare@bham.ac.uk; In the thymus, phenotypically and functionally mature single positive cells are generated from immature CD4+8+ precursors by a process known as positive selection. Although this event is known to involve alphabetaTCR ligation by peptide/MHC complexes expressed on thymic stromal cells, it is clear that positive selecti
Triggering of effector functions on a CD8+ T cell clone upon the aggregation of an activatory CD94/kp39 heterodimer.: J Immunol. 1999 Apr 1;162(7):3996-4002. Unique Identifier : AIDSLINE GENBANK/AF078550; Bellon T; Heredia AB; Llano M; Minguela A; Rodriguez A; Lopez-Botet M; Aparicio P; Seccion de Inmunologia, Hospital de la Princesa, Madrid, Spain.; Some T lymphocytes express the CD94 Ag, which is known to form heterodimers with members of the NKG2 family. We have studied the expression pattern and function of CD94 heterodimers in different alphabeta or gammadelta T cell clones. Most of the CD94+NKG2A- T cells have a low to intermediate expression of CD94 Ag. The
In vitro analysis of complement-dependent HIV-1 cell infection using a model system.: J Immunol. 1999 Apr 1;162(7):4088-93. Unique Identifier : AIDSLINE MED/99218430; Tacnet-Delorme P; Boyer V; Thielens NM; Hernandez JF; Bally I; Sim RB; Desgranges C; Arlaud GJ; Laboratoire d'Enzymologie Moleculaire, Institut de Biologie; Structurale, Grenoble, France.; Previous studies based on the use of human serum as a source of C have provided evidence for the C-dependent enhancement of cell infection by HIV-1. The present study was undertaken to distinguish C from other serum factors and to identify the proteins and the mechanisms involved in C-dependent cell infection by HIV-1
Tolerization of mice to Schistosoma mansoni egg antigens causes elevated type 1 and diminished type 2 cytokine responses and increased mortality in acute infection.: J Immunol. 1999 Apr 1;162(7):4122-32. Unique Identifier : AIDSLINE MED/99218435; Fallon PG; Dunne DW; Department of Pathology, University of Cambridge, United Kingdom.; pgf@mole.bio.cam.ac.uk; The granuloma that surrounds the Schistosoma mansoni egg is the cause of pathology in murine schistosomiasis, and its formation is driven by egg Ag-stimulated type 1 and type 2 cytokines. To determine the role of egg-driven immune responses during schistosome infection we rendered CBA/Ca mice unresponsive to schistoso
B7-2 is required for the progression but not the initiation of the type 2 immune response to a gastrointestinal nematode parasite.: J Immunol. 1999 Apr 1;162(7):4133-9. Unique Identifier : AIDSLINE MED/99218436; Greenwald RJ; Urban JF; Ekkens MJ; Chen S; Nguyen D; Fang H; Finkelman FD; Sharpe AH; Gause WC; Department of Microbiology and Immunology, Uniformed Services; University of the Health Sciences, Bethesda, MD 20814, USA.; T cells require CD28/CTLA-4 costimulatory molecule interactions in addition to Ag-specific signals through the TCR for in vivo effector Th cell function. Some studies have suggested that the ligands for these costimulatory molecules may differentially influence effector T cell function with B7-2 favoring a type 2 resp
CD8 T cells are essential in the development of respiratory syncytial virus-induced lung eosinophilia and airway hyperresponsiveness.: J Immunol. 1999 Apr 1;162(7):4207-11. Unique Identifier : AIDSLINE MED/99218446; Schwarze J; Cieslewicz G; Joetham A; Ikemura T; Hamelmann E; Gelfand EW; Division of Basic Sciences, Department of Pediatrics, National; Jewish Medical and Research Center, Denver, CO 80206, USA.; Viral respiratory infections can cause bronchial hyperresponsiveness and exacerbate asthma. In mice, respiratory syncytial virus (RSV) infection results in airway hyperresponsiveness (AHR) and eosinophil influx into the airways. The immune cell requirements for these responses to RSV infection are not well defined. To
IL-16 as an anti-inflammatory cytokine in rheumatoid synovitis.: Unique Identifier : AIDSLINE MED/99218459; Klimiuk PA; Goronzy JJ; Weyand CM; T lymphocytes are a major component of the inflammatory infiltrate in rheumatoid synovitis, but their exact role in the disease process is not understood. Functional activities of synovial T cells were examined by adoptive transfer experiments in human synovium-SCID mouse chimeras. Adoptive transfer of
Increased peroxynitrite activity in AIDS dementia complex: implications for the neuropathogenesis of HIV-1 infection.: J Immunol. 1999 Apr 1;162(7):4319-27. Unique Identifier : AIDSLINE MED/99218462; Boven LA; Gomes L; Hery C; Gray F; Verhoef J; Portegies P; Tardieu M; Nottet HS; Eijkman-Winkler Institute, Section of Neuroimmunology, Utrecht; University, The Netherlands. L.A.Boven@lab.azu.nl; Oxidative stress is suggested to be involved in several neurodegenerative diseases. One mechanism of oxidative damage is mediated by peroxynitrite, a neurotoxic reaction product of superoxide anion and nitric oxide. Expression of two cytokines and two key enzymes that are indicative of the presence of reactive oxygen
Protective role of beta-chemokines associated with HIV-specific Th responses against perinatal HIV transmission.: J Immunol. 1999 Apr 1;162(7):4355-64. Unique Identifier : AIDSLINE MED/99218467; Wasik TJ; Bratosiewicz J; Wierzbicki A; Whiteman VE; Rutstein RR; Starr SE; Douglas SD; Kaufman D; Sison AV; Polansky M; Lischner HW; Kozbor D; Center for Neurovirology, Department of Neurology, MCP Hahnemann; University, Philadelphia, PA 19102, USA.; To examine the protective role of cellular immunity in the vertical transmission of HIV, we analyzed HIV-specific IL-2 and CTL responses, as well as beta-chemokine expression in HIV-infected and uninfected infants of HIV+ mothers. Our results showed that HIV envelope (
Virus interactions with dendritic cells.: J Gen Virol. 1999 Apr;80 ( Pt 4):823-33. Unique Identifier : AIDSLINE MED/99226931; Klagge IM; Schneider-Schaulies S; Institute for Virology and Immunobiology, University of; Wurzburg, Germany.
Replication capacity of simian immunodeficiency virus in cultured macaque macrophages and dendritic cells is not prerequisite for intravaginal transmission of the virus in macaques.: J Gen Virol. 1999 Apr;80 ( Pt 4):847-55. Unique Identifier : AIDSLINE MED/99226934; Enose Y; Ibuki K; Tamaru K; Ui M; Kuwata T; Shimada T; Hayami M; Institute for Virus Research, Laboratory of Viral Pathogenesis,; Kyoto University, Japan.; In order to test the hypothesis that macrophages and dendritic cells (DCs) in mucosal tissue play an important role in heterosexual transmission of human immunodeficiency virus, the replication capacities of two simian immunodeficiency viruses (SIVs) were examined in cultured macrophages and DCs as well as in cultured
Detection of human immunodeficiency virus type 1 after infection of unstimulated peripheral blood mononuclear cells.: J Gen Virol. 1999 Apr;80 ( Pt 4):857-61. Unique Identifier : AIDSLINE MED/99226935; Shapiro SZ; Maudru T; Peden KW; Laboratory of Retrovirus Research, Center for Biologics; Evaluation and Research, Food and Drug Administration, Bethesda,; MD 20892, USA.; Application of a highly sensitive PCR-based reverse transcriptase (RT) assay to the analysis of the infection of CD4+ cell lines with human immunodeficiency virus type 1 (HIV-1) demonstrated that virus production can be detected as early as 24 h after infection. Most of the signal at 24 h was due to virus production,
Structural similarities between influenza virus matrix protein M1 and human immunodeficiency virus matrix and capsid proteins: an evolutionary link between negative-stranded RNA viruses and retroviruses.: J Gen Virol. 1999 Apr;80 ( Pt 4):863-9. Unique Identifier : AIDSLINE MED/99226936; Harris A; Sha B; Luo M; Department of Microbiology and Center for Macromolecular; Crystallography, University of Alabama at Birmingham, 35294, USA.; The evolutionary relationship of retroviruses to the negative-stranded RNA virus superfamily was examined by comparing protein structures. Since protein structures are more conserved over time than primary protein sequences, three-dimensional structural comparisons permit the identification of evolutionary relationshi
[Brain imaging in AIDS]: J Radiol. 1999 Feb;80(2):99-107. Unique Identifier : AIDSLINE MED/99226181; Bousson V; Brunereau L; Meyohas MC; Levy C; Arrive L; Berthet K; Marsot-Dupuch K; Tubiana JM; Service de Radiologie, Hopital Saint-Antoine, Paris.; Encephalic diseases remain an important problem in AIDS patients despite improvement in the rate of disease spread. We provide data on the current situation and describe the clinical, pathological and imaging features commonly observed in encephalic diseases in AIDS patients.
Circulating levels of beta-chemokines in systemic lupus erythematosus.: J Rheumatol. 1999 Mar;26(3):568-73. Unique Identifier : AIDSLINE MED/99188550; Kaneko H; Ogasawara H; Naito T; Akimoto H; Lee S; Hishikawa T; Sekigawa I; Tokano Y; Takasaki Y; Hirose SI; Hashimoto H; Department of Rheumatology and Internal Medicine, Juntendo; University School of Medicine, Tokyo, Japan.; OBJECTIVE: Recent evidence suggests the role of beta-chemokines and their receptors in human immunodeficiency virus infection. We examined the serum levels of beta-chemokines in patients with systemic lupus erythematosus (SLE). METHODS: The serum levels of beta-chemokines, macrophage inflammatory protein-1alpha (MIP-1
Synovial non-Hodgkin's lymphoma in a human immunodeficiency virus infected patient.: J Rheumatol. 1999 Mar;26(3):696-8. Unique Identifier : AIDSLINE MED/99188571; Peeva E; Davidson A; Keiser HD; Department of Medicine, Albert Einstein College of Medicine and; Jacobi Medical Center, Bronx, NY 10461, USA.; We describe a case of articular non-Hodgkin s lymphoma (NHL) with malignant lymphoma cells observed in synovial fluid. Bone involvement in NHL is common, but an English language Medline search revealed only 14 reported cases of synovial NHL. Although NHL is a well recognized compli
Osteonecrosis and human immunodeficiency virus infection [letter]: J Rheumatol. 1999 Mar;26(3):752-3. Unique Identifier : AIDSLINE MED/99188584; Koeger AC
Primary gastric T-cell lymphomas: report of two cases and a review of the literature.: Unique Identifier : AIDSLINE MED/99240232; Horie R; Yatomi Y; Wakabayashi T; Ohno Y; Eriguchi M; Higashihara M; Nakahara K; Watanabe T; To understand more fully the clinicopathological features of primary gastric T-cell lymphomas (PGTL), we report two cases of PGTL and review the literature. The present cases were not associated with human T-cell leukemia virus type 1 (HTLV-1) and were at clinical stage IIE. In both cases, T-cell origin of the lymphom
[A study on the factors affecting friendship with HIV-infected students in high school: from the survey of AIDS related knowledge, information sources and attitudes in 1989 and 1992]: Nippon Eiseigaku Zasshi. 1999 Jan;53(4):580-6. Unique Identifier : AIDSLINE MED/99207338; Okajima F; Araki S; Murata K; Yokoyama K; Department of Public Health and Occupational Medicine, Graduate; School of Medicine, University of Tokyo, Japan.; To clarify the factors affecting the friendship with human immunodeficiency virus (HIV)-infected persons, a self-reported questionnaire study was conducted in two high schools in Tokyo in 1989 and 1992. A complete set of responses was obtained from 541 (98%) and 517 (99%) students in 1989 and 1992, respectively. The f
[Global situation of TB and its control]: Kekkaku. 1999 Feb;74(2):83-90. Unique Identifier : AIDSLINE MED/99207324; Shimao T; Japan Anti-TB Association, Tokyo.; Tuberculosis occupies 4th place among major causes of death, and the number of new cases is estimated at 7.25 million in 1997, and 99% of TB deaths and 95% of new TB cases are seen in developing countries. TB had been brought under control in developed countries by applying modern TB control programme including chemot
Constitutive cytokine production by primary effusion (body cavity-based) lymphoma-derived cell lines.: Leukemia. 1999 Apr;13(4):634-40. Unique Identifier : AIDSLINE MED/99229686; Drexler HG; Meyer C; Gaidano G; Carbone A; DSMZ-German Collection of Microorganisms & Cell Cultures,; Department of Human and Animal Cell Cultures, Braunschweig.; Primary effusion lymphoma (PEL) is a new lymphoma entity occurring predominantly, but not exclusively in HIV+ patients with acquired immunodeficiency syndrome (AIDS). PEL grows exclusively in body cavities as serous lymphomatous effusion without evidence of mass disease or dissemination. The cells are infected with th
[Strongyloidiasis and HTLV-I infection (letter; comment)]: Med Clin (Barc). 1999 Feb 27;112(7):279. Unique Identifier : AIDSLINE MED/99237110; Calderon E; Capote FJ; Medrano FJ; Soriano V
[AIDS or HIV infection? The health care implications (editorial)]: Med Clin (Barc). 1999 Mar 13;112(9):335-6. Unique Identifier : AIDSLINE MED/99237114; Casabona J
[AZT and 3TC treatment in a pregnant woman with HIV infection (letter)]: Med Clin (Barc). 1999 Mar 13;112(9):358-9. Unique Identifier : AIDSLINE MED/99237121; Pardo MJ; Pedrol E; Coll M; Montull S
[Portal thrombosis in a female patient treated with protease inhibitors (letter)]: Med Clin (Barc). 1999 Mar 13;112(9):359. Unique Identifier : AIDSLINE MED/99237123; Locutura J; Lorenzo JF; Mijan A
Abnormal body-fat distribution in HIV-1-infected children on antiretrovirals [letter]: Lancet. 1999 Apr 10;353(9160):1243-4. Unique Identifier : AIDSLINE MED/99231444; Babl FE; Regan AM; Pelton SI
Liposuction for protease-inhibitor-associated lipodystrophy [letter]: Lancet. 1999 Apr 10;353(9160):1244. Unique Identifier : AIDSLINE MED/99231445; Ponce-de-Leon S; Iglesias M; Ceballos J; Ostrosky-Zeichner L
Australian HIV vaccines trial to begin in the next few months [news]: Lancet. 1999 Apr 10;353(9160):1251. Unique Identifier : AIDSLINE MED/99231448; Loff B; Cordner S
Cytomegalovirus infection in patients with HIV infection.: Mt Sinai J Med. 1999 Mar;66(2):113-24. Unique Identifier : AIDSLINE MED/99200189; Cheung TW; Teich SA; Department of Medicine, Mount Sinai School of Medicine, New York,; NY 10029, USA.; Cytomegalovirus ( CMV ) is responsible for the most common viral opportunistic infection in persons with acquired immunodeficiency virus syndrome (AIDS). Clinical disease due to CMV has been recognized in up to 40% of patients with advanced HIV disease. The most c
Atovaquone compared with dapsone to prevent Pneumocystis carinii pneumonia [letter]: N Engl J Med. 1999 May 13;340(19):1512-3. Unique Identifier : AIDSLINE MED/99240042; Horowitz HW; Wormser GP
Estriol ameliorates autoimmune demyelinating disease: implications for multiple sclerosis.: Neurology. 1999 Apr 12;52(6):1230-8. Unique Identifier : AIDSLINE MED/99229562; Kim S; Liva SM; Dalal MA; Verity MA; Voskuhl RR; Department of Neurology, University of California Los Angeles; School of Medicine, USA.; OBJECTIVE: To evaluate the use of estriol in the treatment of experimental autoimmune encephalomyelitis (EAE) and other cell mediated autoimmune diseases. BACKGROUND: Experimental autoimmune encephalomyelitis is a T helper 1 (Th1)-mediated autoimmune demyelinating disease that is a useful model for the study of immune
[Testing for HIV infection in pregnant women at the obstetric centers in Italy]: Minerva Ginecol. 1999 Jan-Feb;51(1-2):7-14. Unique Identifier : AIDSLINE MED/99246853; D'Ubaldo C; Vucetich A; Pardi G; Ippolito G; Puro V; Centro di Riferimento AIDS, IRCCS Lazzaro Spallanzani, Roma.; BACKGROUND: To assess antenatal HIV testing policy implemented in Italian obstetric centres. METHODS: Cross-sectional study, Site and Participants: Italian obstetric centres. Intervention: structured postal questionnaire. Out-comes: policies and practices of antenatal HIV testing in Italian obstetric centres. RESULTS:
Lower genital tract intraepithelial neoplasia in HIV-infected women: guidelines for evaluation and management.: Obstet Gynecol Surv. 1999 Feb;54(2):131-7. Unique Identifier : AIDSLINE MED/99135164; Spitzer M; Department of Obstetrics & Gynecology, Queens Hospital Center,; Jamaica, New York 11432, USA.; Human immunodeficiency virus (HIV) and human papillomavirus (HPV) are both sexually transmitted viruses with many risk factors in common. Studies have found that HIV-seropositive women are at least five times as likely to be infected with HPV as seronegative controls. In immunocompromised HIV-seropositive women, the r
Comparison of human immunodeficiency virus 1 DNA polymerase chain reaction and qualitative and quantitative RNA polymerase chain reaction in human immunodeficiency virus 1-exposed infants.: Pediatr Infect Dis J. 1999 Jan;18(1):30-5. Unique Identifier : AIDSLINE MED/99135448; Cunningham CK; Charbonneau TT; Song K; Patterson D; Sullivan T; Cummins T; Poiesz B; Department of Pediatrics, SUNY Health Science Center at Syracuse,; NY, USA.; BACKGROUND: HIV-1 RNA PCR is a widely available and sensitive assay but has not been studied for use in early diagnosis of HIV-1 infection in infants. METHODS: Research HIV-1 DNA PCR and HIV-1 RNA PCR were performed on peripheral blood mononuclear cells and plasma, respectively, from 284 blood samples from 204 infants
The natural history of human immunodeficiency virus 1 infection in Haitian infants.: Unique Identifier : AIDSLINE MED/99135453; Jean SS; Pape JW; Verdier RI; Reed GW; Hutto C; Johnson WD Jr; Wright PF; Cornell University Infectious Diseases Research Unit, Institut; National de Laboratoire et de Recherches and Haitian Study Group; on Kaposi's Sarcoma and Opportunistic Infections, Port-au-Prince.; OBJECTIVES: The current study followed HIV-infected women through pregnancy and their infants through the first 2 years of life to determine the rate of vertical transmission of HIV infection from Haitian women, factors in maternal health and obstetrical history that might influence such transmission and the natural h
HIV protease inhibitors: advances in therapy and adverse reactions, including metabolic complications.: Pharmacotherapy. 1999 Mar;19(3):281-98. Unique Identifier : AIDSLINE MED/99236556; Kaul DR; Cinti SK; Carver PL; Kazanjian PH; Department of Internal Medicine, University of Michigan Medical; Center, Ann Arbor 48109-0378, USA.; Protease inhibitors (PIs) effectively inhibit replication of the human immunodeficiency virus (HIV), and reduce mortality and prolong survival in patients with HIV infection. Newer PIs saquinavir (soft gelatin capsule) and amprenavir , as well as other
Clinical guidelines and pharmacist intervention program for HIV-infected patients requiring granulocyte colony-stimulating factor therapy.: Pharmacotherapy. 1999 Mar;19(3):356-62. Unique Identifier : AIDSLINE MED/99236564; Engles-Horton LL; Skowronski C; Mostashari F; Altice FL; Department of Pharmacy, Yale-New Haven Hospital, Connecticut,; USA.; Guidelines, implemented by clinical pharmacists, were developed by the pharmacy and therapeutics subcommittee on a dedicated service caring for hospitalized patients with human immunodeficiency virus infection or the acquired immunodeficiency syndrome (AIDS) who required granulocyte colony-stimulating factor (G-CSF) t
[Primary pulmonary hypertension in an HIV-seropositive patient (letter)]: Presse Med. 1999 Mar 20;28(11):582. Unique Identifier : AIDSLINE MED/99230994; Lambiotte F; Chagnon JL; Fontier C; Vermersch A; Socolovsky C
[Prevalence of cerebro-meningeal cryptococcosis associated with AIDS in Dakar (letter)]: Presse Med. 1999 Apr 10;28(14):741-2. Unique Identifier : AIDSLINE MED/99247027; Hovette P; Camara P; Raphenon G; Soko TO; Burgel PR
HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy.: Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3848-53. Unique Identifier : AIDSLINE MED/99199273; Jeffery KJ; Usuku K; Hall SE; Matsumoto W; Taylor GP; Procter J; Bunce M; Ogg GS; Welsh KI; Weber JN; Lloyd AL; Nowak MA; Nagai M; Kodama D; Izumo S; Osame M; Bangham CR; Department of Immunology, Imperial College School of Medicine,; St. Mary's, Norfolk Place, London W2 1PG, United Kingdom.; The risk of disease associated with persistent virus infections such as HIV-I, hepatitis B and C, and human T-lymphotropic virus-I (HTLV-I) is strongly determined by the virus load. However, it is not known whether a persistent class I HLA-restricted antiviral cytotoxic T lymphocyte (CTL) response reduces viral load a
The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway.: Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3888-93. Unique Identifier : AIDSLINE MED/99199280; Ouyang W; Jacobson NG; Bhattacharya D; Gorham JD; Fenoglio D; Sha WC; Murphy TL; Murphy KM; Department of Pathology and Center for Immunology, Howard Hughes; Medical Institute, Washington University School of Medicine, St.; Louis, MO 63110, USA.; Interleukin 12 (IL-12)-induced T helper 1 (Th1) development requires Stat4 activation. However, antigen-activated Th1 cells can produce interferon gamma (IFN-gamma) independently of IL-12 and Stat4 activation. Thus, in differentiated Th1 cells, factors regulated by IL-12 and Stat4 may be involved in IFN-gamma producti
Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier.: Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3900-5. Unique Identifier : AIDSLINE MED/99199282; Rao VV; Dahlheimer JL; Bardgett ME; Snyder AZ; Finch RA; Sartorelli AC; Piwnica-Worms D; Mallinckrodt Institute of Radiology, Washington University School; of Medicine, St. Louis, MO 63110, USA.; The blood-brain barrier and a blood-cerebrospinal-fluid (CSF) barrier function together to isolate the brain from circulating drugs, toxins, and xenobiotics. The blood-CSF drug-permeability barrier is localized to the epithelium of the choroid plexus (CP). However, the molecular mechanisms regulating drug permeability
[Clinical and economic impact of new antiretroviral treatments (editorial)]: Rev Clin Esp. 1999 Feb;199(2):53-4. Unique Identifier : AIDSLINE MED/99232039; Moreno Guillen S; Perez Elias MJ
[Primary cavity-based lymphoma and HIV infection]: Rev Clin Esp. 1999 Feb;199(2):73-7. Unique Identifier : AIDSLINE MED/99232043; Valencia Ortega ME; Martinez Santos P; Gomez Aguado F; Blanco Quintana F; Laguna Cuesta F; Soriano Vazquez V; Gonzalez Lahoz J; Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos; III, Madrid.; BACKGROUND: Primary cavity-based lymphomas (PCBL) represent and uncommon group on non-Hodgkin lymphomas associated with AIDS. They present as malignant effusions with no bone marrow or lymph node involvement, although some cases with bone marrow infiltration at advanced stages have been reported. Tumoral cells are mon
[Dissociated cholestasis in patients with HIV-1 infection, Prevalence and diagnostic value of liver biopsy]: Rev Clin Esp. 1999 Feb;199(2):81-3. Unique Identifier : AIDSLINE MED/99232045; Macias Sanchez J; Sanchez Quijano A; Delgado de la Cuesta J; Pineda Vergara JA; Leal Noval M; Lissen Otero E; Departamento de Medicina Interna, Hospital Universitario Virgen; del Rocio, Sevilla.; HIV-1 infected patients frequently develop opportunistic diseases involving the liver, particularly individuals with AIDS. Nevertheless, the role of liver biopsy (LB) in these patients is controversial. The prevalence of AC in seropositive subjects and the value of LB in patients with AC was investigated. The prevalen
[Advances in the therapy of HIV infection and implications for clinical research (editorial)]: Rev Med Interne. 1999 Mar;20(3):217-9. Unique Identifier : AIDSLINE MED/99232523; Morlat P
[Adenocarcinoma of unknown primary site with thoracic localization and HIV: four case reports]: Rev Med Interne. 1999 Mar;20(3):272-6. Unique Identifier : AIDSLINE MED/99232532; Courtot H; Martin C; Charvier A; Bru JP; Gaillat J; Service de medecine interne et des maladies infectieuses, centre; hospitalier d'Annecy, France.; INTRODUCTION: Non AIDS-defining cancer would have increased in HIV-patients as suggested by numerous studies. Four cases of adenocarcinoma of unknown primary site with thoracic localization that occurred in HIV-infected patients are described. EXEGESIS: To date, there have been no published data about carcinomas of un
Exercise and immune function. Recent developments.: Sports Med. 1999 Feb;27(2):73-80. Unique Identifier : AIDSLINE MED/99191372; Nieman DC; Pedersen BK; Department of Health and Exercise Science, Appalachian State; University, Boone, North Carolina, USA. niemandc@appstate.edu; Comparison of immune function in athletes and nonathletes reveals that the adaptive immune system is largely unaffected by athletic endeavour. The innate immune system appears to respond differentially to the chronic stress of intensive exercise, with natural killer cell activity tending to be enhanced while neutrophi
Induction of phagocyte-stimulating and Th1-promoting cytokines by in vitro stimulation of human peripheral blood mononuclear cells with Streptococcus pneumoniae.: Scand J Immunol. 1999 Apr;49(4):417-23. Unique Identifier : AIDSLINE MED/99235175; Arv~a E; Andersson B; Department of Clinical Immunology, Goteborg, Sweden.; Polymorphonuclear granulocytes, which provide a major defence against Streptococcus pneumoniae infections, are attracted to and activated by various cytokines. The aim of this study was to analyse the cytokine response of human peripheral blood mononuclear cells to stimulation with S. pneumoniae. Strains belonging to
Cytokine profile in coeliac disease.: Scand J Immunol. 1999 Apr;49(4):441-6. Unique Identifier : AIDSLINE MED/99235178; Lahat N; Shapiro S; Karban A; Gerstein R; Kinarty A; Lerner A; Immunology Research Unit, Lady Davis Carmel Medical Center, Bruce; Rappaport Faculty of Medicine, Technion-Israel Institute of; Technology, Haifa, Israel.; Coeliac disease (CD), an inflammatory enteropathy, is believed to be caused by immune sensitivity to ingested gluten. T-cell activation appears to be implicated in the disease although little is known regarding the role of T-cell subsets, Th1/Th2, and the cytokines they secrete. Reverse transcription-polymerase chain
T(H)1 cytokines are produced in labial salivary glands in Sjogren's syndrome, but also in healthy individuals.: Scand J Rheumatol. 1999;28(2):106-12. Unique Identifier : AIDSLINE MED/99244146; Konttinen YT; Kemppinen P; Koski H; Li TF; Jumppanen M; Hietanen J; Santavirta S; Salo T; Larsson A; Hakala M; Sorsa T; Department of Anatomy, Institute of Biomedicine, University of; Helsinki, Finland.; The aim of the present study was to assess the T cell cytokines IFN-gamma, IL-2 , IL-4 and IL-5 in labial salivary glands (LSG) in Sjogren s syndrome (SS) and healthy controls using RT-PCR and immunohistochemistry. IFN-gamma is always or almost always produced in SS and
AIDS in Spain [news]: Science. 1999 Apr 23;284(5414):567. Unique Identifier : AIDSLINE MED/99253285
Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.: Science. 1999 Apr 23;284(5414):638-41. Unique Identifier : AIDSLINE MED/99234314; Schaeffer EM; Debnath J; Yap G; McVicar D; Liao XC; Littman DR; Sher A; Varmus HE; Lenardo MJ; Schwartzberg PL; National Human Genome Research Institute, National Cancer; Institute, National Institute for Allergy and Infectious; Diseases, NIH, Bethesda, MD 20892, USA.; T cell receptor (TCR) signaling requires activation of Zap-70 and Src family tyrosine kinases, but requirements for other tyrosine kinases are less clear. Combined deletion in mice of two Tec kinases, Rlk and Itk, caused marked defects in TCR responses including proliferation, cytokine production, and apoptosis in vit
Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen.: Science. 1999 Apr 23;284(5414):641-4. Unique Identifier : AIDSLINE MED/99234315; Ballestas ME; Chatis PA; Kaye KM; Department of Medicine, Channing Laboratory, Brigham and Women's; Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA; 02115, USA.; Primary effusion lymphoma (PEL) cells harbor Kaposi s sarcoma-associated herpesvirus (KSHV) episomes and express a KSHV-encoded latency-associated nuclear antigen (LANA). In PEL cells, LANA and KSHV DNA colocalized in dots in interphase nuclei and along mitotic chromosomes. In the absence of KSHV DNA, LANA was diffuse
A role for DNA-PK in retroviral DNA integration.: Science. 1999 Apr 23;284(5414):644-7. Unique Identifier : AIDSLINE MED/99234316; Daniel R; Katz RA; Skalka AM; Institute for Cancer Research, Fox Chase Cancer Center, 7701; Burholme Avenue, Philadelphia, PA 19111, USA.; Retroviral DNA integration is catalyzed by the viral protein integrase. Here, it is shown that DNA-dependent protein kinase (DNA-PK), a host cell protein, also participates in the reaction. DNA-PK-deficient murine scid cells infected with three different retroviruses showed a substantial reduction in retroviral DNA in
Fluticasone propionate induced alterations to lung function and the immunopathology of asthma over time.: Thorax. 1998 Sep;53(9):753-61. Unique Identifier : AIDSLINE MED/99252615; Faul JL; Leonard CT; Burke CM; Tormey VJ; Poulter LW; Department of Respiratory Medicine, James Connolly Memorial; Hospital, Dublin, Ireland.; BACKGROUND: Inhaled corticosteroids are the most widely used treatment for asthma, a disease characterised by both functional and immunopathological abnormalities. This study investigated the relative effects of inhaled corticosteroids on these two features of asthma over time. METHODS: A randomised, double blind, pla
Distinguishing immunosilent AIDS from the acute retroviral syndrome in a frequent blood donor.: Transfusion. 1999 Apr;39(4):383-6. Unique Identifier : AIDSLINE MED/99235670; Kopko P; Calhoun L; Petz L; Department of Pathology, University of California, Los Angeles,; USA.; BACKGROUND: There are seven reports of immunosilent AIDS in which there was a lack of development of anti-HIV for more than 6 months. Thus, when a frequent blood donor presented with clinical findings highly suggestive of overt AIDS, there was concern that he may have had a prolonged immunosilent infection. CASE REP
Utility of cytomegalovirus viral load in renal transplant patients in Argentina.: Transplantation. 1999 Apr 15;67(7):1050-5. Unique Identifier : AIDSLINE MED/99236681; Mas V; Alvarellos T; Albano S; de Boccardo G; Giraudo C; Garrett CT; Ferreira-Gonzalez A; Hospital Privado de Cordoba, Argentina. bmhla@arnet.com.ar; BACKGROUND: Cytomegalovirus ( CMV ) is the most prevalent viral disease in solid organ transplantation. Detection of CMV DNA in peripheral blood mononuclear cells (PBMC) by polymerase chain reaction (PCR) frequently occurs in renal allograft recipients, yielding f
Prospective longitudinal analysis of quantitative Epstein-Barr virus polymerase chain reaction in pediatric liver transplant recipients.: Transplantation. 1999 Apr 15;67(7):1068-70. Unique Identifier : AIDSLINE MED/99236685; Kogan DL; Burroughs M; Emre S; Fishbein T; Moscona A; Ramson C; Shneider BL; Division of Pediatric Gastroenterology, Mount Sinai Medical; Center, New York, New York 10029, USA.; BACKGROUND: Posttransplant lymphoproliferative disease (PTLD) remains a significant cause of morbidity and mortality in pediatric liver transplant recipients. Epstein-Barr Virus (EBV) mismatch associated with more prevalent use of split-liver, reduced size, and living-related transplants has increased the risk of prim
Development and validation of a Western immunoblot assay for detection of antibodies to porcine endogenous retrovirus.: Transplantation. 1999 Apr 15;67(7):939-43. Unique Identifier : AIDSLINE MED/99236664; Matthews AL; Brown J; Switzer W; Folks TM; Heneine W; Sandstrom PA; HIV/Retrovirus Diseases Branch, Division of AIDS, STD, and TB; Laboratory Research, National Center for Infectious Diseases,; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA.; BACKGROUND: Reports that pig endogenous retrovirus (PERV) infects human cells in vitro have heightened the importance of molecular and serologic monitoring of xenograft recipients for evidence of infection with PERV. We report the development and validation of a PERV-specific Western immunoblot assay for the diagnosti
Chemo-immunotherapy of advanced AIDS-related Kaposi's sarcoma.: Tumori. 1999 Jan-Feb;85(1):54-9. Unique Identifier : AIDSLINE MED/99245183; Aversa SM; Cattelan AM; Salvagno L; Meneghetti F; Francavilla E; Sattin L; Sasset L; Cadrobbi P; Division of Medical Oncology, Padua General Hospital, Italy.; AIMS AND BACKGROUND: Kaposi s sarcoma (KS) is the most common neoplastic complication of HIV infection and AIDS. Multiple cytotoxic chemotherapy regimens have been used with various response rates. We have evaluated the efficacy and toxicity of low-dose chemotherapy in patients with poor-prognosis AIDS-related KS and
Identification of CD4+ and CD8+ T cell subsets and B cells in the brain of dogs with spontaneous acute, subacute-, and chronic-demyelinating distemper encephalitis.: Unique Identifier : AIDSLINE MED/99175035; Wunschmann A; Alldinger S; Kremmer E; Baumgartner W; CD4 and CD8 antigen expression of T cells as well as B cell and canine distemper virus (CDV) antigen distribution were immunohistologically examined in the cerebellum of dogs with spontaneous distemper encephalitis. Cellular and viral antigen expression were evaluated at intralesional and extralesional sites and in th
Reduction of CD4+ and CD8+ T lymphocytes during febrile periods in horses experimentally infected with equine infectious anemia virus.: Vet Immunol Immunopathol. 1999 Feb 1;67(2):131-40. Unique Identifier : AIDSLINE MED/99175037; Murakami K; Sentsui H; Shibahara T; Yokoyama T; Laboratory of Viral Ecology, National Institute of Animal Health,; Tsukuba, Ibaraki, Japan. kenji.murakami@yale.edu; Three horses were experimentally infected with equine infectious anemia virus (EIAV). All horses were febrile after inoculation with EIAV and then developed chronic symptoms with intermittent fever. The febrile period was characterized by a rise in body temperature with reduced PBL and erythrocyte counts. Flow cytomet
Experimental infection of calves with bovine leukemia virus (BLV): an applicable model of a retroviral infection.: Vet Immunol Immunopathol. 1999 Feb 1;67(2):195-201. Unique Identifier : AIDSLINE MED/99175043; Ungar-Waron H; Paz R; Brenner J; Yakobson B; Partosh N; Trainin Z; Department of Immunology, Kimron Veterinary Institute, Beit; Dagan, Israel.; An experimental model of chronic infection with bovine leukemia virus (BLV) was established in young calves within a relatively short time. In the sera of all infected calves, precipitating antibodies were detected within 5 weeks after infection but upon disease progression pattern of cellular profiles varied. Three c
Modulation of mucosal and systemic immunity by intranasal interleukin 12 delivery.: Vaccine. 1999 Jan 21;17(3):252-60. Unique Identifier : AIDSLINE MED/99141634; Arulanandam BP; Metzger DW; Department of Microbiology and Immunology, Medical College of; Ohio, Toledo 43614-5806, USA. dmetzger@mco.edu; Interleukin-12 (IL-12) is an important mediator of both cell-mediated and humoral immunity. We have now utilized a noninvasive intranasal (i.n.) delivery system to evaluate the ability of IL-12 to modulate both mucosal and systemic components of the immune system. Mice immunized i.n. with dinitrophenyl conjugated to o
Attempt to modify the immune response developed against FIV gp120 protein by preliminary FIV DNA injection.: Unique Identifier : AIDSLINE MED/99171726; Cuisinier AM; Meyer A; Chatrenet B; Verdier AS; Aubert A; Virbac Laboratories, Carros, France.; Following inactivated virus vaccination trials, the surface glycoprotein gp120 (SU) of the feline immunodeficiency virus (FIV) was considered as one of the determinants for protection. However, several vaccination trials using recombinant Env protein or some Env-derived peptides failed to induce protection. To study t
DNA inoculations with HIV-1 recombinant genomes that express cytokine genes enhance HIV-1 specific immune responses.: Vaccine. 1999 Feb 5;17(5):473-9. Unique Identifier : AIDSLINE MED/99171734; Lee AH; Suh YS; Sung YC; Department of Life Science, Center for Biofunctional Molecules,; School of Environmental Engineering, Pohang University of Science; and Technology, Kyung-Puk, Korea.; Vaccination with HIV-1 DNA sequences induce both humoral and cellular immune responses in experimental animals. However, these responses are relatively weak and are often only transient in their nature. In order to enhance the level of HIV-1 specific immunity, we have engineered HIV-1 DNA constructs which contained va
Effective induction of HIV-specific CTL by multi-epitope using gene gun in a combined vaccination regime.: Vaccine. 1999 Feb 12;17(6):589-96. Unique Identifier : AIDSLINE MED/99173488; Hanke T; Neumann VC; Blanchard TJ; Sweeney P; Hill AV; Smith GL; McMichael A; Molecular Immunology Group, Institute of Molecular Medicine,; University of Oxford, The John Radcliffe Hospital, Headington,; UK. hanke@ermine.ox.ac.uk; Reliable and effective induction of cytotoxic T-lymphocytes (CTL) is one of the prime objectives of vaccine research. Previously, novel HIV vaccine candidates were constructed as a string of CTL epitopes (20 human, 3 macaque and 1 mouse) delivered using a DNA vector [Hanke T, Schneider J, Gilbert SG, Hill AVS, McMicha
2-mercapto N-(azolyl)benzenesulfonamides. VI. Synthesis and anti-HIV activity of some new 2-mercapto-N-(1,2,4-triazol-3-yl)benzenesulfonamide derivatives containing the 1,2,4-triazole moiety fused with a variety of heteroaromatic rings.: Acta Pol Pharm. 1998 Nov-Dec;55(6):473-80. Unique Identifier : AIDSLINE MED/99172789; Brzozowski Z; Department of Chemical Technology of Drugs, Medical University of; Gdansk, Poland.; A series of 2-mercapto-N-(1,2,4-triazol-3-yl)benzenesulfonamide derivatives containing the triazole moiety fused with a variety of heteroaromatic rings [XVI-XXVIII] was obtained by the reactions of 3-methylthio-1,4-2-benzodithiazine 1,1-dioxide derivatives [Ia-d] with 2-hydrazines [IIa-f]. Some of the intermediate 1,1
Synthesis, anti-HIV and anticancer activities of new: Unique Identifier : AIDSLINE MED/99172790
Application of an in situ PCR hybridization method to detection of human T-lymphotropic virus type I-infected cells in the lung.: Acta Med Okayama. 1999 Feb;53(1):1-4. Unique Identifier : AIDSLINE MED/99194395; Qiu Y; Takeuchi T; Chen BK; Ohtsuki Y; Department of Pathology, Kochi Medical School, Nankoku, Japan.; We applied an in situ polymerase chain reaction (PCR) hybridization method in order to detect human T-lymphotropic virus type I-infected cells in routinely-processed paraffin sections of the lung from 13 autopsied patients with adult T-cell leukemia (ATL). Previously reported protocol resulted in somewhat non-specific
Collapsing glomerulopathy: clinical characteristics and follow-up [see comments]: Am J Kidney Dis. 1999 Apr;33(4):652-7. Unique Identifier : AIDSLINE MED/99211840; Grcevska L; Polenakovik M; Department of Nephrology, Clinical Center, Skopje, Republic of; Macedonia.; In 1986, Weiss et al reported a group of patients with nephrotic syndrome, progressive chronic renal failure, and the histopathologic features of glomerular capillary collapse. Similar lesions are often described in human immunodeficiency virus (HIV) nephropathy. We evaluated 893 consecutive nontransplant renal biopsi
Emergency surgery for generalized peritonitis caused by cytomegalovirus colitis in a patient with AIDS.: Am Surg. 1999 May;65(5):397-8. Unique Identifier : AIDSLINE MED/99246233; Albu E; Mukherjee A; Rao D; Sehonanda A; Pai BN; Gerst PH; Department of Surgery, Bronx-Lebanon Hospital Center, Bronx, New; York, USA.; Cytomegalovirus infection of the colon is a late and severe complication in human immunodeficiency virus patients. Despite availability of medical treatment, occasional life-saving emergency surgery must be performed. The controversial surgical aspects of treatment are discussed based upon an unusual case of aseptic g
The changing spectrum of the cutaneous manifestation of HIV disease [letter]: Arch Dermatol. 1999 Apr;135(4):471. Unique Identifier : AIDSLINE MED/99220902; Colebunders R; Vandenbruaene M
Hepatic mitochondrial toxicity from nucleoside analog therapy [letter]: Arch Pathol Lab Med. 1999 Mar;123(3):189. Unique Identifier : AIDSLINE MED/99184309; Finkle HI
Herpesvirus 8 inclusions in primary effusion lymphoma: report of a unique case with T-cell phenotype.: Arch Pathol Lab Med. 1999 Mar;123(3):257-60. Unique Identifier : AIDSLINE MED/99184321; Said JW; Shintaku IP; Asou H; deVos S; Baker J; Hanson G; Cesarman E; Nador R; Koeffler HP; Department of Pathology, UCLA Center for the Health Sciences, Los; Angeles, Calif. 90095, USA.; We describe a case of primary effusion lymphoma with T-cell phenotype, mixed genotype, and intranuclear herpesvirus inclusions visible with the light microscope. Cells were studied by immunohistochemical analysis, in situ hybridization, immunoglobulin and T-cell receptor gene rearrangement, and polymerase chain reacti
Effect low frequency noise exposure on BALB/c mice splenic lymphocytes.: Unique Identifier : AIDSLINE MED/99203052; Aguas AP; Esaguy N; Grande N; Castro AP; Castelo Branco NA; INTRODUCTION: Vibroacoustic disease (VAD) occurs in workers exposed for more 10 yr to large pressure amplitude and low frequency (LPALF) noise (> or = 90dB,
Acceleration of lupus erythematosus-like processes by low frequency noise in the hybrid NZB/W mouse model.: Aviat Space Environ Med. 1999 Mar;70(3 Pt 2):A132-6. Unique Identifier : AIDSLINE MED/99203053; Aguas AP; Esaguy N; Grande NR; Castro AP; Castelo Branco NA; Abel Salazar Institute for Biomedical Sciences, University of; Porto, Portugal.; INTRODUCTION: We investigated the effect of low frequency noise on the natural history of autoimmune diseases using hybrid New Zealand Black (NZB) and White (NZW) male mice that are prone to spontaneously develop systemic lupus erythematosus after 6 mo of age. METHODS: We expos
Increase in CD8+ and CD4+ T lymphocytes in patients with vibroacoustic disease.: Aviat Space Environ Med. 1999 Mar;70(3 Pt 2):A141-4. Unique Identifier : AIDSLINE MED/99203055; Castro AP; Aguas AP; Grande NR; Monteiro E; Castelo Branco NA; Institute for Cellular and Molecular Biology, University of; Porto, Portugal.; INTRODUCTION: Some workers employed by the aviation industry are exposed to large pressure amplitude and low frequency (LPALF) noise (> or =90 dB SPL,
Structural model of the HIV-1 Tat(46-58)-TAR complex.: J Biomol Struct Dyn. 1998 Dec;16(3):683-92. Unique Identifier : AIDSLINE MED/99159989; Seewald MJ; Metzger AU; Willbold D; Rosch P; Sticht H; Lehrstuhl fur Biopolymere der Universitat Bayreuth, Germany.; The trans-activator protein (Tat) of human immunodeficiency virus type 1 (HIV-1) binds to an uridine-rich bulge of an RNA target (TAR; trans-activation responsive element) predominantly via its basic sequence domain. The structure of the Tat(46-58)-TAR complex has been determined by a novel modeling approach relying o
Brownian and essential dynamics studies of the HIV-1 integrase catalytic domain.: J Biomol Struct Dyn. 1998 Dec;16(3):733-45. Unique Identifier : AIDSLINE MED/99159994; Weber W; Demirdjian H; Lins RD; Briggs JM; Ferreira R; McCammon JA; Department of Pharmacology, University of California, San Diego,; La Jolla 92093-0365, USA.; The three-dimensional structure of the active site region of the enzyme HIV-1 integrase is not unambiguously known. This region includes a flexible peptide loop that cannot be well resolved in crystallographic determinations. Here we present two different computational approaches with different levels of resolution an
Infectious diseases in internationally adopted children: findings in children from China, Russia, and eastern Europe.: Adv Pediatr Infect Dis. 1999;14:147-61. Unique Identifier : AIDSLINE MED/99179589; Hostetter MK; Yale University School of Medicine, New Haven, Connecticut, USA.; Conditions in many orphanages provide a fertile environment for infectious diseases uncommonly encountered in industrialized nations. Moreover, health care providers may be unfamiliar with the need to test for these conditions in internationally adopted children. Pediatric infectious disease specialists provide much-n
Inactivation kinetics of model and relevant blood-borne viruses by treatment with sodium hydroxide and heat.: Biologicals. 1998 Sep;26(3):237-44. Unique Identifier : AIDSLINE MED/99225757; Borovec S; Broumis C; Adcock W; Fang R; Uren E; Virology Group, Research and Development, CSL Limited, Bioplasma; Division, 189-209 Camp Road, Broadmeadows, 3047, Australia.; To determine the efficacy of a clean-in-place system for the inactivation of viruses present in human plasma, the effect of 0.1 M sodium hydroxide at 60 degrees C on viral infectivity was investigated. Inactivation of the following model and relevant viruses were followed as a function of time: human hepatitis A virus
Cardiac involvement in human immunodeficiency virus infection.: Rev Port Cardiol. 1999 Feb;18(2):217-20. Unique Identifier : AIDSLINE MED/99237402; Cardoso JS; Faculdade de Medicina do Porto, Portugal.
HIV, UV and immunosuppression.: Photodermatol Photoimmunol Photomed. 1999 Feb;15(1):28-31. Unique Identifier : AIDSLINE MED/99144477; Akaraphanth R; Lim HW; Institute of Dermatology, Bangkok, Thailand.; Cutaneous diseases are common manifestations of infection with human immunodeficiency virus (HIV). Phototherapy with ultraviolet B (UVB) and photochemotherapy with 8-methoxypsoralen plus UVA (PUVA) have been used successfully to treat several of these skin conditions, including psoriasis, folliculitis, pruritus, and e
Explanation of pre-steady-state kinetics and decreased burst amplitude of HIV-1 reverse transcriptase at sites of modified DNA bases with an additional, nonproductive enzyme-DNA-nucleotide complex.: Biochemistry. 1999 Apr 13;38(15):4818-25. Unique Identifier : AIDSLINE MED/99218091; Furge LL; Guengerich FP; Department of Biochemistry and Center in Molecular Toxicology,; Vanderbilt University School of Medicine, Nashville, Tennessee; 37232-0146, USA.; The majority of pre-steady-state kinetic investigations with HIV-1 reverse transcriptase (HIV-1 RT) have reported substoichiometric bursts (30-50%) of product formation in the initial reaction cycle. By using quantitative amino acid analysis, we have revised the extinction coefficient of the HIV-1 RT heterodimer and s
Trimerization specificity in HIV-1 gp41: analysis with a GCN4 leucine zipper model.: Biochemistry. 1999 Apr 27;38(17):5378-85. Unique Identifier : AIDSLINE PDB/1CE0; Shu W; Ji H; Lu M; Department of Biochemistry, Weill Medical College of Cornell; University, New York 10021, USA.; The envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) consists of a complex of two noncovalently associated subunits, gp120 and gp41. Formation of gp120/gp41 oligomers is thought to be dependent on a 4-3 hydrophobic (heptad) repeat located in the amino-terminal region of the gp41 molecule. We have i
[Cavitated pulmonary lesions in a patient with human immunodeficiency virus infection]: Enferm Infecc Microbiol Clin. 1999 Mar;17(3):141-2. Unique Identifier : AIDSLINE MED/99234471; Canizares R; Esparcia AM; Roig P; Garcia A; Ortiz V; Martin C; Merino J; Servicio de Medicina Interna, Hospital Universitario San Juan de; Alicante.
[Fulminant sepsis by Listeria monocytogenes in a patient with coinfection by human immunodeficiency virus (letter)]: Unique Identifier : AIDSLINE MED/99234475; Ricart C; Tornero C; Pardo J; Navarro D
Preventive HIV-1 vaccines: where are we going?: Int J STD AIDS. 1998 Dec;9(12):715-9. Unique Identifier : AIDSLINE MED/99089512; Kent SJ; AIDS Pathogenesis Research Unit, Macfarlane Burnet Centre for; Medical Research, Fairfield, Vic, Australia.
The management of adult male victims of sexual assault in the GUM clinic: a practical guide.: Int J STD AIDS. 1998 Dec;9(12):720-4; quiz 725. Unique Identifier : AIDSLINE MED/99089513; Tomlinson DR; Harrison J; Department of Genitourinary Medicine, St Mary's Hospital, London,; UK.
An outbreak of methicillin-resistant Staphylococcus aureus (MRSA) infection in HIV-seropositive persons.: Int J STD AIDS. 1998 Dec;9(12):726-30. Unique Identifier : AIDSLINE MED/99089514; Smith NP; Nelson MR; Azadian B; Gazzard BG; St Stephen's Centre, London, UK.; Staphylococcus aureus is a cause of considerable morbidity and mortality in HIV-seropositive persons. Although methicillin-resistant S. aureus (MRSA) is encountered worldwide and in many areas of medical care, little has been reported on clinical infection with MRSA in patients with HIV. We report on an outbreak of MR
A general practitioner STD training programme: meeting education and service provision needs.: Int J STD AIDS. 1998 Dec;9(12):731-5. Unique Identifier : AIDSLINE MED/99089515; Wray L; Law C; Barrie SC; Manly Sexual Health Service, New South Wales, Australia.; This paper discusses the development, implementation and evaluation of a training programme in sexually transmitted diseases (STDs) for general practitioners (GPs) belonging to the Divisions of General Practice in the Sydney metropolitan area. The aims of the project were to involve GPs in the management of STDs, sexu
HIV infection among patients with sexually transmitted diseases in rural South Africa.: Int J STD AIDS. 1998 Dec;9(12):736-9. Unique Identifier : AIDSLINE MED/99089516; Wilkinson D; Wilkinson N; Centre for Epidemiological Research in Southern Africa, Medical; Research Council, Hlabisa, South Africa. wilkinsd@mrc.ac.za; A cross-sectional study of 360 patients presenting with sexually transmitted diseases (STDs) to a primary care clinic in KwaZulu/Natal, South Africa was done. Prevalence of HIV infection was 42.5%. HIV-infected patients were of similar age to uninfected patients (mean age 25.1 vs
Changing patterns of HIV transmission and better targeting for intervention strategies.: Int J STD AIDS. 1998 Dec;9(12):740-3. Unique Identifier : AIDSLINE MED/99089517; Donisi A; Tomasoni D; Ripamonti D; Milini P; Palvarini L; Cattane A; Paraninfo G; Casari S; Cadeo GP; Carosi G; Clinic of Infectious and Tropical Diseases, University of; Brescia, Italy.; We considered the HIV population of our area, comparing demographic characteristics between 2 consecutive 6-year periods to assess the current patterns of HIV transmission. All HIV-positive patients referred to our hospital from January 1985 to December 1996 were included in the study and were classified into 2 period
Perceptions and patterns of reproductive tract infections in a young rural population in North-West Namibia.: Int J STD AIDS. 1998 Dec;9(12):744-50. Unique Identifier : AIDSLINE MED/99089518; Harms G; Iyambo SN; Corea A; Radebe F; Fehler HG; Ballard RC; National AIDS Control Programme, Windhoek, Namibia.; nacp@iafrica.com.na; Syndromic management of sexually transmitted diseases (STDs) is strongly promoted in Namibia . However, no data are available on rates of asymptomatic reproductive tract infections (RTIs) which would remain undetected and thus untreated in the general population. This study was aim
Activity of thalidomide in AIDS-related Kaposi's sarcoma and correlation with HHV8 titre.: Int J STD AIDS. 1998 Dec;9(12):751-5. Unique Identifier : AIDSLINE MED/99089519; Fife K; Howard MR; Gracie F; Phillips RH; Bower M; Medical Oncology Unit, Charing Cross Hospital, London, UK.; k.fife@cxwms.ac.uk; A phase II study of thalidomide was conducted to evaluate its efficacy and toxicity in the treatment of cutaneous AIDS-related Kaposi s sarcoma (AIDS-KS). To evaluate whether clinical response is correlated with titre of human herpesvirus 8 (HHV8) DNA in peripheral blood, levels were determined by serial end-point dil
Risk profile of female sex workers who participate in a routine penicillin prophylaxis programme in Surabaya, Indonesia.: Int J STD AIDS. 1998 Dec;9(12):756-60. Unique Identifier : AIDSLINE MED/99089520; Joesoef MR; Valleroy LA; Kuntjoro TM; Kamboji A; Linnan M; Barakbah Y; Idajadi A; St Louis ME; Division of STD Prevention, Centers for Disease Control and; Prevention (CDC), Atlanta, Georgia 30333, USA.; We conducted a sexually transmitted disease (STD) prevalence survey of 1867 female sex workers in Surabaya, Indonesia , some of whom reported participation in a routine penicillin prophylaxis programme. In Surabaya, 34% of female sex workers had received a prophylactic penicillin
Diagnostic accuracy of HIV-associated central nervous system toxoplasmosis.: Int J STD AIDS. 1998 Dec;9(12):761-4. Unique Identifier : AIDSLINE MED/99089521; Marra CM; Krone MR; Koutsky LA; Holmes KK; Department of Neurology, School of Medicine, University of; Washington, Seattle, USA. cmarra@u.washington.edu; Our objective was to examine the accuracy of diagnosis of HIV-associated central nervous system (CNS) toxoplasmosis. Individuals diagnosed with HIV-associated CNS toxoplasmosis and controls were ascertained from a population-based database. Diagnosis was confirmed by response to therapy or by histology. Symptoms, resu
Problems in physician's classification and reporting of congenital syphilis.: Unique Identifier : AIDSLINE MED/99089522; Yetman RJ; Risser WL; Barth BA; Risser JM; Hwang LY; The diagnosis of congenital syphilis (CS) in newborns can only be made through a review of the mothers testing and treatment history and through the infants clinical and laboratory findings. We describe difficulties in the classification of CS by physicians and the health department during a recent syphilis epidemic
Human leukocyte derived interferon-alpha in a hydrophilic gel for the treatment of intravaginal warts in women: a placebo-controlled, double-blind study.: Int J STD AIDS. 1998 Dec;9(12):769-72. Unique Identifier : AIDSLINE MED/99089523; Syed TA; Ahmadpour OA; Department of Clinical Physiology, Malmo University Hospital,; University of Lund, Sweden. tasyed@itsa.ucsf.edu; This placebo-controlled, double-blind study was aimed to evaluate the clinical efficacy, safety and tolerability of human leukocyte interferon-alpha (2 x 10(6) IU/g) incorporated in a hydrophilic gel (hydroxyethylcellulose, 1%) to cure intravaginal warts in women. Preselected, subjects (n=60) who ranged between 18 and
Highly active antiretroviral therapy (HAART) and prolonged survival of a patient with an HIV-related Burkitt lymphoma, despite an intracardiac relapse.: Int J STD AIDS. 1998 Dec;9(12):773-5. Unique Identifier : AIDSLINE MED/99089524; Brinkman K; Delnoy PP; de Pauw B; Department of Internal Medicine, University Hospital, Nijmegen,; The Netherlands. K.Brinkman@olvg.nl
The sonographic image of inflamed inguinal lymph nodes in primary syphilis.: Int J STD AIDS. 1998 Dec;9(12):776-7. Unique Identifier : AIDSLINE MED/99089525; Bohmer U; Schmid-Wendtner MH; Korting HC; Kouznetsov AW; Department of Dermatology, Ludwig-Maximilian University, Munich,; Germany.
Chlamydia trachomatis as a probable cause of prostatitis [letter]: Int J STD AIDS. 1998 Dec;9(12):779. Unique Identifier : AIDSLINE MED/99089526; Taylor-Robinson D
Website as a tool for patient education in sexually transmitted diseases [letter]: Int J STD AIDS. 1998 Dec;9(12):779-80. Unique Identifier : AIDSLINE MED/99089527; Harry TC; Snobl H
Provision of a dedicated 'men only clinic' (MOC) within a mixed sex GUM clinic increases uptake of sexual health services by men [letter]: Int J STD AIDS. 1998 Dec;9(12):780. Unique Identifier : AIDSLINE MED/99089528; Walsh JC; Holmes DA; Lawrence AG; Daniels D
Injector-inmates and anal sex with another man in prison [letter]: Int J STD AIDS. 1998 Dec;9(12):781. Unique Identifier : AIDSLINE MED/99089529; Gore SM; Bird AG; Hutchinson SJ
Use of the term 'Chlamydia' [letter]: Int J STD AIDS. 1998 Dec;9(12):782. Unique Identifier : AIDSLINE MED/99089530; Taylor-Robinson D; Ridgway GL
CD4- and CD56-positive T-cell line, MTA, established from natural killer-like T-cell leukemia/lymphoma.: Int J Hematol. 1999 Apr;69(3):180-5. Unique Identifier : AIDSLINE MED/99239163; Emi N; Abe A; Kasai M; Kohno A; Tanimoto M; Kimura H; Kawashima K; Ito M; Mori N; Saito H; First Department of Internal Medicine, Nagoya University School; of Medicine, Japan. j45973a@nucc.cc.nagoya-u.ac.jp; We have established a T-cell line, MTA, from the peripheral blasts of a patient with natural killer (NK)-like T-cell leukemia/lymphoma. The MTA cell displays a T-cell and NK-cell phenotype (CD2+, CD3+, CD4+, CD56+) identical to freshly isolated leukemic blasts from the patient. This cell line shows clonal T-cell recep
A case of T-lineage lymphoblastic lymphoma/leukemia with t(4;11)(q21;p15) that switched to myelomonocytic leukemia at relapse.: Int J Hematol. 1999 Apr;69(3):196-9. Unique Identifier : AIDSLINE MED/99239165; Kawakami K; Miyanishi S; Amakawa R; Hayashi T; Kurata M; Nakamura F; Tanaka Y; Ohno Y; Shiku H; Division of Hematology, Tenri Hospital, Nara, Japan.; A 51-year-old Japanese woman, initially diagnosed with T-lineage (CD2+, CD7+, CD3-, CD4-, CD8-) lymphoblastic lymphoma with t(4;11)(q21;p15), relapsed with acute myelomonocytic leukemia with the identical chromosomal abnormality. Southern-blot analysis revealed clonal rearrangements of an immunoglobulin heavy chain ge
Allogenic bone marrow transplantation as a treatment for adult T-cell leukemia.: Int J Hematol. 1999 Apr;69(3):203-5. Unique Identifier : AIDSLINE MED/99239167; Obama K; Tara M; Sao H; Taji H; Morishima Y; Mougi H; Maruyama Y; Osame M; Internal Medicine, Kagoshima City Hospital, Kagoshima City,; Japan. obama@bc.mbn.or.jp; We performed allogenic bone marrow transplantation (BMT) in two adult T-cell leukemia (ATL) patients with HLA-identical siblings as donors. One patient, with acute ATL, relapsed 3 months after BMT. The other, with chronic ATL, has become free of disease over 18 months after the BMT from his human T-cell lymphotropic v
Rapid telomere shortening in children.: Blood. 1999 May 1;93(9):2824-30. Unique Identifier : AIDSLINE MED/99233643; Zeichner SL; Palumbo P; Feng Y; Xiao X; Gee D; Sleasman J; Goodenow M; Biggar R; Dimitrov D; HIV and AIDS Malignancy Branch, National Cancer Institute,; National Institutes of Health, Bethesda, MD, USA.; zeichner@nih.gov; Telomere shortening may reflect the total number of divisions experienced by a somatic cell and is associated with replicative senescence. We found that the average rate of telomere shortening in peripheral blood mononuclear cells (PBMCs) obtained longitudinally from nine different infants during the first 3 years of
TCR gene rearrangements and expression of the pre-T cell receptor complex during human T-cell differentiation.: Blood. 1999 May 1;93(9):3033-43. Unique Identifier : AIDSLINE MED/99233667; Blom B; Verschuren MC; Heemskerk MH; Bakker AQ; van Gastel-Mol EJ; Wolvers-Tettero IL; van Dongen JJ; Spits H; Division of Immunology, The Netherlands Cancer Institute,; Amsterdam, The Netherlands.; Recent studies have identified several populations of progenitor cells in the human thymus. The hematopoietic precursor activity of these populations has been determined. The most primitive human thymocytes express high levels of CD34 and lack CD1a. These cells acquire CD1a and differentiate into CD4(+)CD8(+) through
Immunopotentiating activity of nigerooligosaccharides for the T helper 1-like immune response in mice.: Biosci Biotechnol Biochem. 1999 Feb;63(2):373-8. Unique Identifier : AIDSLINE MED/99208999; Murosaki S; Muroyama K; Yamamoto Y; Kusaka H; Liu T; Yoshikai Y; Research & Development Section, Takeda Food Products Ltd., Itami,; Japan.; The immunopotentiating activity of nigerooligosaccharides (NOS), a mixture of nigerose, nigerosyl glucose and nigerosyl maltose, was studied in vitro and in vivo in mice. Mitogen-induced proliferation of splenocytes from normal mice was augmented in a dose-dependent manner by nigerose of NOS. NOS enhanced interleukin
A computer exploration of some properties of non-linear stochastic partnership models for sexually transmitted diseases with stages.: Math Biosci. 1999 Mar 1;156(1-2):123-45. Unique Identifier : AIDSLINE MED/99220601; Sleeman CK; Mode CJ; Department of Mathematics and Computer Science, Drexel; University, Philadelphia, PA 19104, USA.; In this paper, branching process approximations to non-linear stochastic partnership models for sexually transmitted diseases in heterosexual populations were used to find points in the parameter space such that an epidemic would occur. At selected points in the parameter space, samples of Monte Carlo realizations of
Some state space models of HIV pathogenesis under treatment by anti-viral drugs in HIV-infected individuals.: Math Biosci. 1999 Mar 1;156(1-2):69-94. Unique Identifier : AIDSLINE MED/99220599; Tan WY; Xiang Z; Department of Mathematical Sciences, University of Memphis, TN; 38152, USA. tanwy@msci.memphis.edu; In this paper we have extended the model of HIV pathogenesis under treatment by anti-viral drugs given by Perelson et al. [A.S. Perelson et al., Science 271 (1999) 1582] to a stochastic model. By using this stochastic model as the stochastic system model, we have developed a state space model for the HIV pathogenesis
A new design of stochastic partnership models for epidemics of sexually transmitted diseases with stages.: Math Biosci. 1999 Mar 1;156(1-2):95-122. Unique Identifier : AIDSLINE MED/99220600; Mode CJ; Sleeman CK; Department of Mathematics and Computer Science, Drexel; University, Philadelphia, PA 19014, USA. cmode@mcs.drexel.edu; A problem of importance in modelling epidemics of sexually transmitted diseases is the development of mathematical structures accommodating sexual and other contacts among members of a population. Because these models may be complex, it is often necessary to use computer intensive methods in their analysis, which rais
[Neurologic manifestations associated with HIV infections at the Bobo-Dioulasso Hospital Center (Burkina Faso)]: Bull Soc Pathol Exot. 1999 Feb;92(1):23-6. Unique Identifier : AIDSLINE MED/99231130; Millogo A; Ki-Zerbo GA; Sawadogo AB; Ouedraogo I; Yameogo A; Tamini MM; Peghini M; Service de medecine interne, Centre hospitalier national Souro; Sanou, Burkina Faso.; Neurological manifestations of HIV infection are frequent and diverse. Diagnosis is often difficult due to geographical factors. 686 of the 3409 patients admitted to the Internal Medicine ward of Bobo-Dioulasso in 1995-1996 were HIV seropositive. This represents a prevalence of 20.1%. The sociodemographic and clinical
[Intramuscular injections in Sub-saharan African children, apropos of a frequently misunderstood pathology: the complications related to intramuscular quinine injections]: Bull Soc Pathol Exot. 1999 Feb;92(1):33-7. Unique Identifier : AIDSLINE MED/99231134; Barennes H; Unite de vaccinologie et de recherche operationnelle, Centre; Muraz, Bobo-Dioulasso, Burkina-Faso.; In West Africa, the incidence of poliomyelitis has decreased in the past years thanks to intensive immunization campaigns. Nowadays intramuscular injection is the main reason for paralysis of the legs in African children as well as attendance at Rehabilitation Centres. Intramuscular injection of quinine is the most fr
[Problems produced by the use of antitubercular agents in a reference service for HIV/AIDS in Abidjan (Cote d'Ivoire)]: Bull Soc Pathol Exot. 1999 Feb;92(1):42-5. Unique Identifier : AIDSLINE MED/99231136; Kakou A; Eholie S; Yao B; Coulibaly M; Ehui E; Bissagnene E; Aoussi E; Kadio A; Clinique des maladies infectieuses, CHU Treichville, Abidjan,; Cote d'Ivoire.; This study reports on the experience using antituberculosis drugs in a HIV/AIDS reference service in Abidjan during a 64 month period. Prevalence of tuberculosis is 1.9% out of a total of 23,957 patients. The annual incidence rate increased slowly from 0.9% in 1990 to 3.5% in 1995. Seropositivity to HIV is 90.8%. Pred
Australian university students agree with Clinton's definition of sex [letter]: BMJ. 1999 Apr 10;318(7189):1011-12. Unique Identifier : AIDSLINE MED/99212026; Richters J; Song A
Molecular mechanisms of resistance: free energy calculations of mutation effects on inhibitor binding to HIV-1 protease.: Protein Sci. 1998 Aug;7(8):1750-6. Unique Identifier : AIDSLINE MED/99180408; Rick SW; Topol IA; Erickson JW; Burt SK; Frederick Biomedical Supercomputing Center, SAIC-Frederick,; NCI-Frederick Cancer Research and Development Center, Maryland; 27102, USA. rick@ncicrf.gov; The changes in the inhibitor binding constants due to the mutation of isoleucine to valine at position 84 of HIV-1 protease are calculated using molecular dynamics simulations. The calculations are done for three potent inhibitors--KNI-272, L-735,524 ( ind
B cell lymphoproliferative disorders following hematopoietic stem cell transplantation: risk factors, treatment and outcome.: Unique Identifier : AIDSLINE MED/99181747; Gross TG; Steinbuch M; DeFor T; Shapiro RS; McGlave P; Ramsay NK; Wagner JE; Filipovich AH; Twenty-six cases of B cell lymphoproliferative disorder (BLPD) were identified among 2395 patients following hematopoietic stem cell transplants (HSCT) for which an overall incidence of BLPD was 1.2%. The true incidence was probably higher, since 9/26 of the diagnoses were made at autopsy. No BLPD was observed followi
Harm reduction: Australia as a case study.: Bull N Y Acad Med. 1995 Winter;72(2):339-47. Unique Identifier : AIDSLINE MED/99201590; Wodak A; Alcohol and Drug Service, St. Vincent's Hospital, Darlinghurst,; NSW, Australia.; This paper explicates the term, harm reduction ; demonstrates that harm reduction has a long tradition; and uses one country, Australia , as a case study. Harm reduction can be understood as policies and programs which are designed to reduce the adverse consequences of mood alt
When science and politics collide: the federal response to needle-exchange programs.: Bull N Y Acad Med. 1995 Winter;72(2):380-96. Unique Identifier : AIDSLINE MED/99201594; Lurie P; Center for AIDS Prevention Studies, University of California, San; Francisco 94105, USA.
Research on needle exchange: redefining the agenda.: Unique Identifier : AIDSLINE MED/99201595; Hantman JA; Urban Health Initiative, New York Academy of Medicine, NY 10029,; USA.; Researchers studying needle-exchange programs in the United States pursue a two-fold agenda that requires answers to these questions: (1) Do such programs successfully reduce HIV seroprevalence among injecting drug users? (2) Do they promote drug use? Several federal laws and regulatio
Voluntary newborn HIV-1 antibody testing: a successful model program for the identification of HIV-1-seropositive infants.: Bull N Y Acad Med. 1995 Winter;72(2):443-53. Unique Identifier : AIDSLINE MED/99201597; Abrams EJ; Bateman DA; Department of Pediatrics, Harlem Hospital Center, College of; Physicians and Surgeons, Columbia University, New York, NY 10037,; USA.; Harlem Hospital in New York City has one of the highest HIV-1 newborn seroprevalence rates in the United States . We report the results of a program introduced in 1993 and designed to identify HIV-1-seropositive (HIV+) newborns at birth. All new mothers, independent of risk, received HI
Adult AIDS in New York City--risk categories.: Bull N Y Acad Med. 1995 Winter;72(2):538-9. Unique Identifier : AIDSLINE MED/99201604; Chiasson MA; New York City Department of Health, NY 10013, USA.
AIDS and HIV infection in the United Kingdom: monthly report. HIV infection acquired through sex between men.: Commun Dis Rep CDR Wkly. 1999 Mar 26;9(13):121-2. Unique Identifier : AIDSLINE MED/99246728
[Cytomegalovirus, pregnancy and occupational risk]: Arch Pediatr. 1998 Jan;5(1):24-6. Unique Identifier : AIDSLINE MED/99239613; Boussemart T; Baudon JJ; Garbarg-Chenon A; Costil J; Unite de neonatologie, hopital d'enfants Armand-Trousseau,; Paris, France.; BACKGROUND: Female health professionals are not more likely to contract cytomegalovirus ( CMV ) infection than the general population. CASE REPORT: Generalized congenital infection was diagnosed in a neonate. His mother was a n
Association between exercise and HIV disease progression in a cohort of homosexual men.: Ann Epidemiol. 1999 Feb;9(2):127-31. Unique Identifier : AIDSLINE MED/99155161; Mustafa T; Sy FS; Macera CA; Thompson SJ; Jackson KL; Selassie A; Dean LL; Division of Biostatistics, Department of Health and Environmental; Control, Columbia, South Carolina, USA.; PURPOSE: To study the relationship between exercise and human immunodeficiency virus (HIV) disease progression. METHODS: 415 individuals (156 HIV positive, 259 HIV negative), from a cohort study of 851 homosexual men from New York City, 1985-1991. By 1991, 68 of the 156 persons developed Acquired Immune Deficiency Syn
Age-adjusted death rates: consequences of the Year 2000 standard.: Ann Epidemiol. 1999 Feb;9(2):93-100. Unique Identifier : AIDSLINE MED/99155156; Sorlie PD; Thom TJ; Manolio T; Rosenberg HM; Anderson RN; Burke GL; Epidemiology and Biometry Program, National Heart, Lung, and; Blood Institute, NIH, Bethesda, MD 20892, USA.; PURPOSE: For nearly 60 years, official U.S. mortality statistics have been age-adjusted using the age distribution from the U.S. population for the year 1940. A new population standard, the projected Year 2000 U.S. standard, has been approved for use by the Department of Health and Human Services (DHHS). It will be im
Mobilization of intracellular calcium stores participates in the rise of [Ca2+]i and the toxic actions of the HIV coat protein GP120.: Eur J Neurosci. 1999 Apr;11(4):1167-78. Unique Identifier : AIDSLINE MED/99203346; Medina I; Ghose S; Ben-Ari Y; INSERM, Unit 29, Hopital de Port-Royal, Paris, France.; The HIV envelope glycoprotein, GP120, increases intracellular Ca2+ concentration and induces degeneration of human and animal neurons in culture. Using patch-clamp recordings and Ca2+ imaging techniques, we have now examined the contribution of intracellular stores of calcium in the effects of GP120. We report that in
Foci of tuberculosis transmission in central Los Angeles.: Am J Respir Crit Care Med. 1999 Apr;159(4 Pt 1):1081-6. Unique Identifier : AIDSLINE MED/99210346; Barnes PF; Yang Z; Pogoda JM; Preston-Martin S; Jones BE; Otaya M; Knowles L; Harvey S; Eisenach KD; Cave MD; Center for Pulmonary and Infectious Disease Control, Departments; of Cell Biology and Medicine, University of Texas Health Center; at Tyler, Tyler, Texas, USA. pbarnes@uthct.edu; To identify sites of tuberculosis transmission and to determine the contribution of HIV-infected patients to tuberculosis morbidity in an urban area, we prospectively evaluated 249 patients with culture-proven tuberculosis in central Los Angeles. Restriction fragment length polymorphism (RFLP) analysis was performed o
Viruses and bacteria in bronchial samples from patients with primary hypogammaglobulinemia.: Am J Respir Crit Care Med. 1999 Apr;159(4 Pt 1):1199-204. Unique Identifier : AIDSLINE MED/99210363; Kainulainen L; Nikoskelainen J; Vuorinen T; Tevola K; Liippo K; Ruuskanen O; National Public Health Institute, Turku, Finland.; leena.kainulainen@utu.fi; Viruses and bacteria in bronchoalveolar lavage fluids, protected specimen brush samples, and bronchial biopsies from 14 patients with primary hypogammaglobulinemia (11 patients with common variable immunodeficiency [CVID] and three patients with X-linked agammaglobulinemia [XLA]) were analyzed. At the time of the stud
Outcome of mother to infant acquired GBV-C/HGV infection.: Arch Dis Child Fetal Neonatal Ed. 1999 Jan;80(1):F72-3. Unique Identifier : AIDSLINE MED/99257668; Zuin G; Saccani B; Di Giacomo S; Tanzi E; Zanetti AR; Principi N; Fourth Paediatric Department, Universita di Milano, Istituto di; Scienze Biomediche Sacco, Italy.; Twelve children born to hepatitis C virus antibody GBV-C/HGV RNA positive mothers who acquired GBV-C/HGV infection by the vertical or perinatal route were studied. Most (91%) were persistently GBV-C/HGV RNA positive up to 12 months of age. Four out of six cases who acquired GBV-C/HGV alone had normal alanine amino tra
The effects of injury on the adaptive immune response.: Shock. 1999 Mar;11(3):153-9. Unique Identifier : AIDSLINE MED/99202649; Lederer JA; Rodrick ML; Mannick JA; Department of Surgery, Harvard Medical School, Brigham and; Women's Hospital, Boston, Massachusetts 02115, USA.; For more than thirty years it has been apparent that serious injury in humans and experimental animals is associated with a decrease in immune functions dependent upon T cells, the principal cells involved in initiating adaptive immune responses. This review focuses on more recent evidence that T helper cell function
Neutralizing antibodies have limited effects on the control of established HIV-1 infection in vivo.: Immunity. 1999 Apr;10(4):431-8. Unique Identifier : AIDSLINE MED/99244192; Poignard P; Sabbe R; Picchio GR; Wang M; Gulizia RJ; Katinger H; Parren PW; Mosier DE; Burton DR; Department of Immunology, The Scripps Research Institute, La; Jolla, California 92037, USA.; Neutralizing antibodies can protect against challenge with HIV-1 in vivo if present at appropriate concentrations at the time of viral challenge, but any role in the control of established infection is unclear. Here, we show that high serum concentrations of neutralizing monoclonal antibodies, either singly or as a co
Analysis of a successful immune response against hepatitis C virus.: Immunity. 1999 Apr;10(4):439-49. Unique Identifier : AIDSLINE MED/99244193; Cooper S; Erickson AL; Adams EJ; Kansopon J; Weiner AJ; Chien DY; Houghton M; Parham P; Walker CM; Department of Structural Biology, Stanford University School of; Medicine, California 94305-5400, USA. scooper@cmgm.stanford.edu; To investigate the type of immunity responsible for resolution of hepatitis C virus (HCV) infection, we monitored antibody and intrahepatic cytotoxic T lymphocyte (CTL) responses during acute (
Transfusional transmitted viruses in pregnancy.: J Pediatr Endocrinol Metab. 1998;11 Suppl 3:901-14. Unique Identifier : AIDSLINE MED/99191264; Eleftheriou A; Kalakoutis G; Pavlides N; Virus Reference Laboratory, Arch. Makarios III Hospital, Nicosia,; Cyprus.; Blood has long been recognized as a vehicle for transmission of infectious organisms and as molecular laboratory technology has advanced, a seemingly endless array of infectious agents has occasionally been documented to be blood transmitted. Transfusion associated hepatitis (TAH) has been the most common serious cons
[One year treatment with lamivudine in different hepatitis B virus related hepatic diseases]: Gastroenterol Hepatol. 1999 Mar;22(3):117-21. Unique Identifier : AIDSLINE MED/99245004; Buti M; Cotrina M; Cruz de Castro E; Jardi R; Rodriguez F; Esteban R; Guardia J; Servicio de Hepatologia, Hospital Universitario Valle de; Hebron, Barcelona.; BACKGROUND: Three month administration of lamivudine in patients with chronic hepatitis B produces a transitory inhibition of the DNA of the hepatitis B virus (HBV). AIM: The aim of this study was to evaluate the efficacy and safety of one year treatment with lamivudine in patients with chronic hepatitis B and liver t
Local evaluation of a rapid HIV assay for use in developing countries.: Trop Med Int Health. 1999 Mar;4(3):216-21. Unique Identifier : AIDSLINE MED/99237729; Zaw M; Frerichs RR; Oo KY; Eskes N; AIDS Prevention and Control Program, Yangon, Myanmar.; We present a research scheme for evaluating inexpensive HIV rapid tests in a developing country setting and assess the field validity of the Sero Strip HIV 1/2 rapid test. The research design features the random allocation of 100 true HIV-positive and 100 true HIV-negative serum specimens to 4 groups, followed by blin
Zidovudine to prevent mother-to-infant HIV transmission in developing countries: a view from Thailand [letter]: Trop Med Int Health. 1999 Mar;4(3):236-7; discussion 237-8. Unique Identifier : AIDSLINE MED/99237732; Kumphitak A; Cawthorne P; Lakhonphol S; Kasi-Sedapan S; Sanaeha S; Unchit N; Wilson D
Zidovudine against mother-to-child HIV transmission [letter]: Trop Med Int Health. 1999 Mar;4(3):237-8. Unique Identifier : AIDSLINE MED/99237733; Colebunders R; Coppieters Y
Dangerous T-cell amnesia [news; comment]: Nat Med. 1999 May;5(5):483-4. Unique Identifier : AIDSLINE MED/99244224; Gorochov G
Evolution of the fittest ends in tragedy [news; comment]: Nat Med. 1999 May;5(5):488-9. Unique Identifier : AIDSLINE MED/99244227; Hirsch VM
Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy.: Nat Med. 1999 May;5(5):512-7. Unique Identifier : AIDSLINE MED/99244233; Finzi D; Blankson J; Siliciano JD; Margolick JB; Chadwick K; Pierson T; Smith K; Lisziewicz J; Lori F; Flexner C; Quinn TC; Chaisson RE; Rosenberg E; Walker B; Gange S; Gallant J; Siliciano RF; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21205, USA.; Combination therapy for HIV-1 infection can reduce plasma virus to undetectable levels, indicating that prolonged treatment might eradicate the infection. However, HIV-1 can persist in a latent form in resting CD4+ T cells. We measured the decay rate of this latent reservoir in 34 treated adults whose plasma virus lev
HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression [see comments]: Nat Med. 1999 May;5(5):518-25. Unique Identifier : AIDSLINE MED/99244234; Pitcher CJ; Quittner C; Peterson DM; Connors M; Koup RA; Maino VC; Picker LJ; Department of Pathology, The University of Texas Southwestern; Medical Center, Dallas 75235-9072, USA.; The role of HIV-1-specific CD4+ T-cell responses in controlling HIV-1 infection remains unclear. Previous work has suggested that such cells are eliminated in the early stages of infection in most subjects, and thus cannot substantially contribute to host defense against HIV-1. Here, using flow cytometric detection of
Emerging cytopathic and antigenic simian immunodeficiency virus variants influence AIDS progression [see comments]: Nat Med. 1999 May;5(5):535-41. Unique Identifier : AIDSLINE MED/99244236; Kimata JT; Kuller L; Anderson DB; Dailey P; Overbaugh J; Department of Microbiology, University of Washington, Seattle; 98195, USA.; Genetic variants of human and simian immunodeficiency virus (HIV and SIV) that evolve during the course of infection and progression to AIDS are phenotypically and antigenically distinct from their progenitor viruses present at early stages of infection. However, it has been unclear how these late variants, which are
[HIV seroprevalence in patients seen at sexually-transmitted disease and family planning centers in Spain, 1995-1996. AIDS Programs of the Autonomic Communities and Network of sexually-transmitted disease, HIV and family planning centers]: Unique Identifier : AIDSLINE MED/99241389; BACKGROUND: The sexually-transmitted diseases (STD s) centers are good sentinels for monitoring the sexual transmitting of HIV. This study analyzes the results of voluntary HIV tests run in 1995 and 1996 within a network of STD, HIV and family planning centers in Spain . METHODS: Sta
Antisense RNA gene therapy for studying and modulating biological processes.: Cell Mol Life Sci. 1999 Mar;55(3):334-58. Unique Identifier : AIDSLINE MED/99245238; Weiss B; Davidkova G; Zhou LW; Department of Pharmacology, MCP Hahnemann University,; Philadelphia, Pennsylvania 19129, USA. weissb@auhs.edu; Agents that produce their effects through an antisense mechanism offer the possibility of developing highly specific alternatives to traditional pharmacological antagonists, thereby providing a novel class of therapeutic agents, ones which act at the level of gene expression. Among the antisense compounds, antisense R
Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts.: Cell Mol Life Sci. 1999 Mar;55(3):423-36. Unique Identifier : AIDSLINE MED/99245240; Gothel SF; Marahiel MA; Philipps University Marburg, Germany.; Cyclosporine A therapy for prophylaxis against graft rejection revolutionized human organ transplantation. The immunosuppressant drugs cyclosporin A (CsA), FK506 and rapamycin block T-cell activation by interfering with the signal transduction pathway. The target proteins for CsA and FK506 were found to be cyclophilin
Lymphocyte subpopulations in patients with multiple primary tumors.: Cancer. 1999 May 1;85(9):2073-6. Unique Identifier : AIDSLINE MED/99237761; Robinson E; Segal R; Struminger L; Faraggi D; El'ad-Yarum R; Mekori T; Northern Israel Oncology Center, Rambam Medical Center and; Faculty of Medicine, Technion-Israel Institute of Technology,; Haifa.; BACKGROUND: Cancer patients with single tumors live longer today due to earlier detection and improved treatment methods. For this reason, the authors see more patients who develop a second primary tumor. The etiology of the second tumor can be the same as the first, whether treatment-induced or unknown. The prognoses
Chemokines in chronic progressive neurological diseases: HTLV-1 associated myelopathy and multiple sclerosis.: J Neurovirol. 1999 Feb;5(1):102-8. Unique Identifier : AIDSLINE MED/99204971; Calabresi PA; Martin R; Jacobson S; Department of Clinical Neuroscience, Rhode Island Hospital-Brown; University, Providence 02903, USA.; It is hypothesized that in MS and HTLV-1, chemokine and chemokine receptor expression are important mechanisms by which T cells migrate to sites of inflammation. Preliminary evidence supports the roles of several chemokines, including MIP 1beta, in mediating the enhanced migration capacity of MS derived PBLs. In addit
Chemokine and chemokine receptor expression in the central nervous system.: J Neurovirol. 1999 Feb;5(1):13-26. Unique Identifier : AIDSLINE MED/99204961; Hesselgesser J; Horuk R; Department of Immunology, Berlex Biosciences, Richmond,; California 94806, USA.; A decade ago several new cytokines were described that orchestrated the activation and migration of immune cells. These newly described cytokines, of which interleukin-8 (IL-8) was a representative member, defined a novel group of molecules called chemokines (chemotactic cytokines). Chemokines are low molecular weight
Dissemination of C. neoformans to the central nervous system: role of chemokines, Th1 immunity and leukocyte recruitment.: J Neurovirol. 1999 Feb;5(1):76-81. Unique Identifier : AIDSLINE MED/99204968; Huffnagle GB; McNeil LK; Department of Internal Medicine, University of Michigan, Ann; Arbor 48109-0642, USA.; Cryptococcus neoformans is a fungus that possesses two properties unique for yeast: (1) production of a polysaccharide capsule and (2) neurotropism. The natural route of infection by C. neoformans is the respiratory tract; thus, factors that regulate the development and recruitment of memory Th1 cells and monocytes in
Presentation of tumor antigens by phagocytic dendritic cell clusters generated from human CD34+ hematopoietic progenitor cells: induction of autologous cytotoxic T lymphocytes against leukemic cells in acute myelogenous leukemia patients.: Cancer Res. 1999 May 1;59(9):2150-8. Unique Identifier : AIDSLINE MED/99247562; Fujii S; Fujimoto K; Shimizu K; Ezaki T; Kawano F; Takatsuki K; Kawakita M; Matsuno K; The Center for Bone Marrow Transplantation and Immunotherapy,; Institute for Clinical Research, Kumamoto National Hospital,; Japan.; The use of antigen-presenting dendritic cells (DCs) is currently proposed for tumor immunotherapy through generation of CTLs to tumor antigens in cancer patients. In this study, DCs were differentiated using granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-alpha from CD34+ hematopoietic proge
HIV and hepatitis B surveillance in First Nations alcohol and drug treatment centers in British Columbia, Canada.: Int J Circumpolar Health. 1998;57 Suppl 1:280-4. Unique Identifier : AIDSLINE MED/99193250; Martin JD; Mathias RG; Health Canada, Medical Services Branch, Vancouver, British; Columbia, Canada.; Data have been lacking on the prevalence of HIV and hepatitis B (HB) infections in the North American Indian population in Canada . In January 1992, surveillance was introduced into two residential First Nations alcohol and drug treatment centers in British Columbia as part of an AI
Alcohol consumption among Alaskan drug users.: Int J Circumpolar Health. 1998;57 Suppl 1:447-53. Unique Identifier : AIDSLINE MED/99193283; Turner SJ; Paschane DM; Johnson ME; Fisher DG; Fenaughty AM; University of Alaska Anchorage, USA.; This study investigated predictors of alcohol consumption among drug users not currently in treatment in Anchorage, Alaska. Data were collected from 114 female and 269 male drug users via structured interviews. Alcohol consumption was defined as estimated number of drinks consumed in the last 30 days. Results revealed
Communicable diseases surveillance.: Commun Dis Intell. 1999 Feb 18;23(2):60-7. Unique Identifier : AIDSLINE MED/99222714
Severe hepatitis in a HIV-positive subject under treatment with protease inhibitor [letter]: Ital J Gastroenterol Hepatol. 1999 Jan-Feb;31(1):85-6. Unique Identifier : AIDSLINE MED/99191211; Nigro L; Romano F; Tosto S; Zagami A; Bruno S; Nunnari A
Combination therapy with stavudine (d4T) plus didanosine (ddI) in children with human immunodeficiency virus infection. The Pediatric AIDS Clinical Trials Group 327 Team.: Pediatrics. 1999 May;103(5):e62. Unique Identifier : AIDSLINE MED/99240968; Kline MW; Van Dyke RB; Lindsey JC; Gwynne M; Culnane M; Diaz C; Yogev R; McKinney RE Jr; Abrams EJ; Mofenson LM; Department of Pediatrics, Baylor College of Medicine and Texas; Children's Hospital, Houston, TX 77030, USA.; OBJECTIVES: To evaluate the safety, tolerance, and antiviral activity of combination therapy with stavudine ( d4T ) plus didanosine (dd
Inhibitory effects of constituents from Cynomorium songaricum and related triterpene derivatives on HIV-1 protease.: Chem Pharm Bull (Tokyo). 1999 Feb;47(2):141-5. Unique Identifier : AIDSLINE MED/99171243; Ma C; Nakamura N; Miyashiro H; Hattori M; Shimotohno K; Research Institute for Wakan-Yaku (Traditional Sino-Japanese; Medicines), Toyama Medical and Pharmaceutical University, Japan.; From CH2Cl2 and MeOH extracts of the stems of Cynomorium songaricum RUPR. (Cynomoriaceae), ursolic acid and its hydrogen malonate were isolated as inhibitors of human immunodeficiency virus type 1 (HIV-1) protease, with 50% inhibitory concentrations (IC50) of 8 and 6 microM, respectively. Amongst various synthesized d
[Clinical investigation of 15 patients with pulmonary cryptococcosis--clinical comparison of HTLV-I carriers and non-carriers]: Nihon Kokyuki Gakkai Zasshi. 1999 Feb;37(2):108-14. Unique Identifier : AIDSLINE MED/99230653; Matsuyama W; Mizoguchi A; Iwami F; Hirotsu Y; Kanazawa H; Koreeda Y; Kawabata M; Fukunaga H; Osame M; Department of Respiratory Medicine, National Minami-kyushu; Hospital.; We investigated 15 pulmonary cryptococcosis patients. The group had a mean age of 51.7 years, and 6 (40%) of the patients were women. Cryptococcosis was primary in 13 patients and secondary in 2 (diabetes mellitus and smoldering adult T-cell leukemia). Eight patients were asymptomatic and 9 patients were detected by m
Human immunodeficiency virus gene regulation as a target for antiviral chemotherapy.: Antivir Chem Chemother. 1999 Jan;10(1):1-14. Unique Identifier : AIDSLINE MED/99179610; Daelemans D; Vandamme AM; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium. Dirk.Daelemans@uz.kuleuven.ac.be; Inhibitors interfering with human immunodeficiency virus (HIV) gene regulation may have great potential in anti-HIV drug (combination) therapy. They act against different targets to currently used anti-HIV drugs, reduce virus production from acute and chronically infected cells and are anticipated to elicit less virus
Characterization of human immunodeficiency virus type 1 resistant to modified cyclodextrin sulphate (mCDS71) in vitro.: Antivir Chem Chemother. 1999 Jan;10(1):15-21. Unique Identifier : AIDSLINE MED/99179611; Mori H; Otake T; Oishi I; Kurimura T; Osaka Prefectural Institute of Public Health, Japan.; mori@iph.pref.osaka.jp; Drug resistance of human immunodeficiency virus type 1 (HIV) to modified cyclodextrin sulphate (mCDS71) has been analysed with respect to both the in vitro appearance of resistance to the compound and the mechanism of the acquisition of resistance. Resistant strains could be obtained in all three strains (NL432, KK-1
PMTI, a broadly active unusual single-stranded polyribonucleotide, inhibits human immunodeficiency virus replication by multiple mechanisms.: Antivir Chem Chemother. 1999 Jan;10(1):23-32. Unique Identifier : AIDSLINE MED/99179612; Buckheit RW Jr; Lackman-Smith C; Snow MJ; Halliday SM; White EL; Ross LJ; Agrawal VK; Broom AD; Microbiology Research Department, Southern Research Institute,; Frederick, MD 21701, USA. buckheit@sri.org; Poly(1-methyl-6-thioinosinic acid), or PMTI, is a single-stranded polyribonucleotide and is the first homopolyribonucleotide devoid of Watson-Crick hydrogen bonding sites to show potent human immunodeficiency virus (HIV) inhibition. PMTI was found to be active when evaluated against a variety of low passage clinical H
Fractions of chemically oversulphated galactosaminoglycan sulphates inhibit three enveloped viruses: human immunodeficiency virus type 1, herpes simplex virus type 1 and human cytomegalovirus.: Antivir Chem Chemother. 1999 Jan;10(1):33-8. Unique Identifier : AIDSLINE MED/99179613; Di Caro A; Perola E; Bartolini B; Marzano M; Liverani L; Mascellani G; Benedetto A; Cellai L; Centro di Virologia, IRCCS L Spallanzani, Roma, Italy.; A series of chemically oversulphated galactosaminoglycans (SO3H:COOH ratio > or = 2) were tested in vitro as antiviral agents against human immunodeficiency virus type 1 (HIV-1), the aetiological agent of AIDS, and against herpes simplex virus type 1 and human cytomegalovirus , two
Synthesis of dual function (5R,6R)- and (5S,6S)-5-bromo-6-methoxy-5,6-dihydro-AZT-5'-(para-bromophenyl methoxyalaninyl phosphate) as novel spermicidal and anti-HIV agents.: Antivir Chem Chemother. 1999 Jan;10(1):39-46. Unique Identifier : AIDSLINE MED/99179614; Jan ST; Shih MJ; Venkatachalam TK; D'Cruz OJ; Chen CL; Uckun FM; Drug Discovery Program, Hughes Institute, St Paul, MN 55113, USA.; We synthesized a novel compound, 5-bromo-6-methoxy-5,6-dihydro-AZT-5 - (p-bromophenyl methoxyalaninyl phosphate), which had an EC50 value of 5 microM in sperm motility assays. This is > 1 log10 better than that of the detergent spermicide nonoxynol-9 (EC50 81 microM). The compound also displayed a potent anti-human im
AZT-5'-(p-bromophenyl methoxyalaninyl phosphate) as a potent and non-toxic anti-human immunodeficiency virus agent.: Unique Identifier : AIDSLINE MED/99179615; Jan ST; Zhu Z; Tai HL; Shih MJ; Venkatachalam TK; Uckun FM; Drug Discovery Program, Hughes Institute, Roseville, MN 55113,; USA.; The potency and selectivity index of the AZT-phenyl phosphate derivatives in thymidine kinase (TK)-deficient T cells were substantially enhanced by introducing a single para-bromo substitutent in the phenyl moiety. AZT-5 -(p-bromophenyl methoxyalaninyl phosphate) was 43-fold more potent than AZT-5 -(phenyl methoxyalan
Paclitaxel in the treatment of human immunodeficiency virus 1-associated Kaposi's sarcoma--drug-drug interactions with protease inhibitors and a nonnucleoside reverse transcriptase inhibitor: a case report study.: Unique Identifier : AIDSLINE MED/99253430; Nannan Panday VR; Hoetelmans RM; van Heeswijk RP; Meenhorst PL; Inghels M; Mulder JW; Beijnen JH; Department of Medical Oncology, The Netherlands Cancer; Institute/Antoni van Leeuwenhoek Hospital, Amsterdam.; apvnp@slz.nl; PURPOSE: To describe the pharmacokinetics of paclitaxel and to investigate the interaction potential with protease inhibitors ( indinavir ,
Immunological background in children with persistent diarrhea in Ghana.: Pediatr Int. 1999 Apr;41(2):162-7. Unique Identifier : AIDSLINE MED/99237369; Taniguchi K; Rikimaru T; Yartey JE; Akpedonu P; Armar-Klemesu MA; Nkrumah FK; Kamiya H; Kishi K; Armar DA; Noguchi Memorial Institute for Medical Research, University of; Ghana, Accra, Ghana. tanigk@nih.go.jp; BACKGROUND: Persistent diarrheal diseases have become one of the most serious medical problems in developing countries, but few studies have been conducted to determine the risk factors. In the present study, we investigated the nutritional and immunological background in children with persistent diarrhea in compariso
Indinavir-induced nephropathy.: Clin Nephrol. 1999 Mar;51(3):181-3. Unique Identifier : AIDSLINE MED/99199664; Grabe DW; Eisele G; Miller C; Singh J; Stein D; Albany College of Pharmacy, N.Y., USA.; We report the case of a 38-year-old male who developed renal insufficiency while on the protease inhibitor, indinavir . This patient had an increase in serum creatinine over a period of approximately one year, along with persistently abnormal urinalysi
Recurrent major depressive disorder among human immunodeficiency virus (HIV)-positive and HIV-negative intravenous drug users: findings of a 3-year longitudinal study.: Compr Psychiatry. 1999 Jan-Feb;40(1):31-4. Unique Identifier : AIDSLINE MED/99122262; Johnson JG; Rabkin JG; Lipsitz JD; Williams JB; Remien RH; Columbia University and the New York State Psychiatric Institute,; NY 10032, USA.; A longitudinal study was conducted to investigate the association between human immunodeficiency virus (HIV) infection, history of major depressive disorder (MDD), and persistent or recurrent MDD among intravenous drug users. Psychiatric disorders were assessed in a sample of HIV-positive (HIV+) and HIV-negative (HIV-
Viral and host factors in determining response of relapsers with chronic hepatitis C to retreatment with interferon.: Dig Dis Sci. 1999 May;44(5):1013-9. Unique Identifier : AIDSLINE MED/99249691; Almasio PL; Di Marco V; Bonura C; Fuschi P; Camma C; Lo Iacono O; Artini M; Natoli C; Di Stefano R; Levrero M; Craxi A; Dipartimento di Igiene e Microbiologia, Universita di Palermo,; Italy.; In chronic hepatitis C the rate of relapse after an end-of-treatment response to interferon may exceed 50%. The usefulness of retreatment of relapsers with interferon in obtaining a complete sustained response and the role of clinical, virological and immunological features in determining long-term efficacy of retreat
Highly active antiretroviral therapy leading to resolution of porphyria cutanea tarda in a patient with AIDS and hepatitis C.: Dig Dis Sci. 1999 May;44(5):1034-7. Unique Identifier : AIDSLINE MED/99249694; Rich JD; Mylonakis E; Nossa R; Chapnick RM; Department of Medicine, The Miriam Hospital, Brown University; School of Medicine, Providence, Rhode Island 02906, USA.; The association between HIV infection and porphyria cutanea tarda (PCT) is not well established. Since almost all HIV-infected patients with PCT previously described in the literature had additional risk factors for PCT, it is still unclear if HIV infection and not a cofactor such as hepatitis C virus is the trigger f
Endoscopic features of intestinal smooth muscle tumor in a child with AIDS.: Dig Dis Sci. 1999 May;44(5):910-5. Unique Identifier : AIDSLINE MED/99249675; Molle ZL; Bornemann P; Desai N; Clarin E; Anderson V; Rabinowitz SS; Department of Pathology, SUNY Health Science Center at Brooklyn,; New York 11203, USA.; Intestinal leiomyosarcomas are exceedingly rare in immunologically intact children, except during infancy. While leiomyosarcomas account for less than 2% of all soft tissue tumors in childhood, they are the second most frequent malignancy in children with the acquired immunodeficiency syndrome (AIDS). In this cohort t
[HIV: resistance and cross-resistance as the crux (news)]: Dtsch Med Wochenschr. 1999 Apr 9;124(14):A28. Unique Identifier : AIDSLINE MED/99247005
Mixed reconstitution of mutated subunits of HIV-1 reverse transcriptase coexpressed in Escherichia coli - two tags tie it up.: Eur J Biochem. 1999 Apr;261(1):10-8. Unique Identifier : AIDSLINE MED/99203494; Maier G; Dietrich U; Panhans B; Schroder B; Rubsamen-Waigmann H; Cellai L; Hermann T; Heumann H; Max-Planck-Institut fur Biochemie, Martinried, Germany.; The active form of HIV-1 reverse transcriptase (RT) is a p66/p51 heterodimer, in which the p51 subunit is generated by C-terminal proteolytic cleavage of p66. A well-known problem of p66 recombinant expression is partial cleavage of a 15-kDa peptide from the C-terminus by host proteases that can not be completely supp
Women's interest in vaginal microbicides.: Fam Plann Perspect. 1999 Jan-Feb;31(1):16-23. Unique Identifier : AIDSLINE MED/99154190; Darroch JE; Frost JJ; Alan Guttmacher Institute (AGI), New York, USA.; CONTEXT: Each year, an estimated 15 million new cases of sexually transmitted diseases (STDs), including HIV, occur in the United States . Women are not only at a disadvantage because of their biological and social susceptibility, but also because of the methods that are available for p
Condom use and HIV risk behaviors among U.S. adults: data from a national survey.: Unique Identifier : AIDSLINE MED/99154191; Anderson JE; Wilson R; Doll L; Jones TS; Barker P; Behavioral Intelligence Research Branch, Centers for Disease; Control and Prevention (CDC), Atlanta, USA.; CONTEXT: How much condom use among U.S. adults varies by type of partner or by risk behavior is unclear. Knowledge of such differentials would aid in evaluating the progress being made toward goals for levels of condom use as part of the Healthy People 2000 initiative. METHODS: Data were analyzed from the 1996 Nationa
GATHER guide to counseling.: Popul Rep J. 1998 Dec;(48):1-31. Unique Identifier : AIDSLINE MED/99195841; Rinehart W; Rudy S; Drennan M
Intensity and mechanisms of in vitro xenorecognition of adult pig pancreatic islet cells by CD4+ and CD8+ lymphocytes from type I diabetic or healthy subjects.: Diabetologia. 1999 Mar;42(3):330-5. Unique Identifier : AIDSLINE MED/99194450; Lalain S; Chaillous L; Gouin E; Sai P; Cellular and Molecular Immuno-Endocrinology,; University/INRA/ENVN, Nantes, France.; The intensity and mechanisms of cell-mediated rejection of pig islet cells were studied in 49 Type I diabetic and 34 healthy subjects. Human peripheral mononuclear cells proliferated strongly in response to pig islet cells (p
[Multifocal MALT lymphoma and acute cytomegalovirus gastritis revealing CD4 lymphopenia without HIV infection]: Gastroenterol Clin Biol. 1999 Jan;23(1):132-6. Unique Identifier : AIDSLINE MED/99236354; Longo F; Hebuterne X; Michiels JF; Maniere A; Caroli-Bosc FX; Rampal P; Federation des Maladies de l'Appareil Digestif, Hopital de; l'Archet 2, Nice.; We report the case of a 63 year-old female who presented with a seven-year history of epigastric pain and a sudden overall deterioration. Gastroscopy demonstrated inflammatory aspect and ulceration in the antrum and fundus. Histology showed a lymphocytic infiltrate consistent with low grade mucosa-associated lymphoid
Recurrent and new hepatitis C virus infection after liver transplantation.: Unique Identifier : AIDSLINE MED/99197103; Everhart JE; Wei Y; Eng H; Charlton MR; Persing DH; Wiesner RH; Germer JJ; Lake JR; Zetterman RK; Hoofnagle JH; Chronic infection with the hepatitis C virus (HCV) is the most common reason for liver transplantation. We examined the results of laboratory tests for HCV on a cohort of patients who received a liver transplant between 1990 and 1994 at three large centers. Seven hundred twenty-two recipients and 604 donors were teste
Quantitative antibody responses to structural (Core) and nonstructural (NS3, NS4, and NS5) hepatitis C virus proteins among seroconverting injecting drug users: impact of epitope variation and relationship to detection of HCV RNA in blood.: Unique Identifier : AIDSLINE MED/99197112; Beld M; Penning M; van Putten M; Lukashov V; van den Hoek A; McMorrow M; Goudsmit J; To gain insight into the natural history of hepatitis C virus (HCV), 13 human immunodeficiency virus (HIV)-seronegative injecting drug users were studied who seroconverted for HCV as determined by third-generation enzyme-linked immunosorbent assay, showed an ensuing antibody response to HCV, and were not treated with
Influence of human immunodeficiency virus infection on chronic hepatitis B in homosexual men.: Hepatology. 1999 Apr;29(4):1306-10. Unique Identifier : AIDSLINE MED/99197114; Colin JF; Cazals-Hatem D; Loriot MA; Martinot-Peignoux M; Pham BN; Auperin A; Degott C; Benhamou JP; Erlinger S; Valla D; Marcellin P; Service d'Hepatologie, Centre de Recherche Claude Bernard sur; les Hepatites Virales and INSERM U481, Clichy, France.; The aim of this study was to assess the influence of human immunodeficiency virus (HIV) infection on chronic hepatitis B. In a series of 132 (65 anti-HIV positive) homosexual non-drug addicted men with chronic hepatitis B, the liver function was assessed with biochemical tests; the degree of hepatitis B virus (HBV) re
What once was lost, now is found: restoration of hepatitis B-specific immunity after treatment of chronic hepatitis B.: Hepatology. 1999 Apr;29(4):1331-3. Unique Identifier : AIDSLINE MED/99197119; Koziel MJ; Infectious Disease Division Beth Israel Deaconess Medical Center; Boston, MA, USA.
Multicenter study of lamivudine therapy for hepatitis B after liver transplantation.Lamivudine Transplant Group.: Hepatology. 1999 May;29(5):1581-6. Unique Identifier : AIDSLINE MED/99234143; Perrillo R; Rakela J; Dienstag J; Levy G; Martin P; Wright T; Caldwell S; Schiff E; Gish R; Villeneuve JP; Farr G; Anschuetz G; Crowther L; Brown N; Section of Gastroenterology, Ochsner Clinic, New Orleans, LA; 70121, USA. rperrillo@Ochsner.org; Hepatitis B after liver transplantation is often fatal, and no proven medical therapy exists for this condition. We chose to study the potential efficacy of lamivudine therapy for patients with chronic hepatitis B after liver transplantation. Fifty-two patients with chronic hepatitis B after liver transplantation were
Inhibition of HIV-1 rgp120 binding to CD4+ T cells by monoclonal antibodies directed against the gp120 C1 or C4 region.: Immunol Lett. 1998 Aug;63(1):19-25. Unique Identifier : AIDSLINE MED/98383939; Kropelin M; Susal C; Daniel V; Opelz G; Department of Transplantation Immunology, Institute of; Immunology, University of Heidelberg, Germany.; m.kroepelin@dkfz-heidelberg.de; Reagents which block the interaction of HIV-1 gp120 with CD4+ T cell are of therapeutic interest. We assessed the ability of the murine monoclonal antibody (mAb) 87-135/9 to bind to the rgp120 C1 region and to block the CD4 interaction, and compared this with the reactivity of the rat mAb 388/389 or the human mAbs F10
Specific interaction of conformational polypeptides derived from HIV gp120 with human T lymphocyte CD4 receptor.: Immunol Lett. 1998 Aug;63(1):27-32. Unique Identifier : AIDSLINE MED/98383940; Liu M; Zeng J; Robey FA; Oral and Pharyngeal Cancer Branch, National Institute of Dental; Research, National Institutes of Health, Bethesda, MD 20892, USA.; Specifically cross-linked peptides (peptomers) have been prepared from the repeating sequences of the C4 domains of glycoproteins 120 present in different isolates of human immunodeficiency virus (HIV). In order to investigate if the HIV C4 peptomers could function as gp120 protein, we have used a novel protein-bindin
Endogenous tumor necrosis factor-alpha contributes to lymphoproliferation induced by simian immunodeficiency virus variant, SIVsmmPBj14.: Immunol Lett. 1998 Aug;63(1):49-51. Unique Identifier : AIDSLINE MED/98383943; Hodge S; Novembre FJ; Dewhurst S; Department of Microbiology and Immunology, University of; Rochester Medical Center, NY 14642, USA.; The simian immunodeficiency virus (SIV) isolate, SIVsmmPBj14, contains an immunoreceptor tyrosine-based activation motif (ITAM) within its nef gene product and triggers efficient lymphoproliferation in vitro. In experimentally inoculated macaque monkeys, this virus causes acutely lethal enteropathy, which is accompani
High frequency of the CCR5 deletion allele in Gypsies living in Hungary.: Immunol Lett. 1998 Aug;63(1):57-8. Unique Identifier : AIDSLINE MED/98383945; Szalai C; Csaszar A; Czinner A; Szabo T; Falus A; Heim Pal Pediatric Hospital, Budapest, Hungary.; szalai@heim.sote.h
A dichotomous role for nitric oxide in protection against blood stage malaria infection.: Immunol Lett. 1999 Mar 15;67(1):1-9. Unique Identifier : AIDSLINE MED/99231551; Taylor-Robinson AW; Smith EC; Department of Biology, University of Leeds, UK.; bgyawtr@leeds.ac.uk; Nitric oxide (NO) is cytotoxic and cytostatic to blood stage malaria parasites in vitro, but the precise mechanism(s) by which it mediates an effect in vivo is not known. In particular, whether or not control of acute parasitemia depends on the presence of NO is unclear. We have shown previously that blocking NO synth
Functional skewing of bone marrow-derived dendritic cells by Th1- or Th2-inducing cytokines.: Immunol Lett. 1999 Mar 15;67(1):63-8. Unique Identifier : AIDSLINE MED/99231559; Sato M; Iwakabe K; Kimura S; Nishimura T; Section of Genetic Engineering, Research Center for Genetic; Engineering and Cell Transplantation, Tokai University School of; Medicine, Isehara, Japan.; To investigate the functional difference of bone marrow (BM)-derived dendritic cells (DC), BM cells were cultured under three different cytokine conditions and the induced DC were temporarily designated as DC0, DC1, or DC2 cells. DC0 were induced by culture of BM cells with granulocyte macrophage colony-stimulating fa
Interleukin-12 is capable of generating an antigen-specific Th1-type response in the presence of an ongoing infection-driven Th2-type response.: Infect Immun. 1999 May;67(5):2166-71. Unique Identifier : AIDSLINE MED/99242795; Schopf LR; Bliss JL; Lavigne LM; Chung CL; Wolf SF; Sypek JP; Genetics Institute, Inc., Department of Preclinical Biology; Andover, Massachusetts 01810, USA. lschopf@lpsi.barc.usda.gov; Previously we demonstrated that recombinant murine interleukin-12 (rmIL-12) administration can promote a primary Th1 response while suppressing the Th2 response in mice primed with 2,4, 6-trinitrophenyl-keyhole limpet hemocyanin (TNP-KLH). The present studies examined the capacity of rmIL-12 to drive a Th1 response to
Antibody response to Cryptococcus neoformans proteins in rodents and humans.: Infect Immun. 1999 May;67(5):2218-24. Unique Identifier : AIDSLINE MED/99242802; Chen LC; Goldman DL; Doering TL; Pirofski La; Casadevall A; Department of Microbiology and Immunology, Department of; Medicine, Albert Einstein College of Medicine, Bronx, New York; 10461-2187, USA.; The prevalence and specificity of serum antibodies to Cryptococcus neoformans proteins was studied in mice and rats with experimental infection, in individuals with or without a history of potential laboratory exposure to C. neoformans, human immunodeficiency virus (HIV)-positive individuals who developed cryptococcos
Immune response to Nocardia brasiliensis antigens in an experimental model of actinomycetoma in BALB/c mice.: Infect Immun. 1999 May;67(5):2428-32. Unique Identifier : AIDSLINE MED/99242830; Salinas-Carmona MC; Torres-Lopez E; Ramos AI; Licon-Trillo A; Gonzalez-Spencer D; Departamentos de Inmunologia y, Facultad de Medicina y Hospital; Universitario Dr. Jose E. Gonzalez, 64460 Monterrey, Nuevo; Leon, Mexico. msalinas@ccr.dsi.uanl.mx; Nine- to twelve-week-old BALB/c mice were injected in footpads with 10(7) CFU of a Nocardia brasiliensis cell suspension. Typical actinomycetoma lesions, characterized by severe local inflammation with abscess and fistula formation, were fully established by day 28 after infection. These changes presented for 90 days,
Cellular immune responses to Neisseria meningitidis in children.: Unique Identifier : AIDSLINE MED/99242833; Pollard AJ; Galassini R; Rouppe van der Voort EM; Hibberd M; Booy R; Langford P; Nadel S; Ison C; Kroll JS; Poolman J; Levin M; There is an urgent need for effective vaccines against serogroup B Neisseria meningitidis. Current experimental vaccines based on the outer membrane proteins (OMPs) of this organism provide a measure of protection in older children but have been ineffective in infants. We postulated that the inability of OMP vaccines
In vivo analysis of secreted aspartyl proteinase expression in human oral candidiasis.: Unique Identifier : AIDSLINE MED/99242836; Naglik JR; Newport G; White TC; Fernandes-Naglik LL; Greenspan JS; Greenspan D; Sweet SP; Challacombe SJ; Agabian N; Oral AIDS Research Unit, Department of Oral Medicine and; Pathology, GKT Guy's Hospital, London SE1 9RT, United Kingdom.; Secreted aspartyl proteinases are putative virulence factors in Candida infections. Candida albicans possesses at least nine members of a SAP gene family, all of which have been sequenced. Although the expression of the SAP genes has been extensively characterized under laboratory growth conditions, no studies have an
Deficiency in tumor necrosis factor alpha activity does not impair early protective Th1 responses against blood-stage malaria.: Infect Immun. 1999 May;67(5):2660-4. Unique Identifier : AIDSLINE MED/99242864; Sam H; Su Z; Stevenson MM; McGill University Centre for the Study of Host Resistance and; Montreal General Hospital Research Institute, Montreal, Quebec,; Canada.; Blood-stage Plasmodium chabaudi AS infection was controlled by 4 weeks in mice with deletion of tumor necrosis factor p55 and p75 receptors (TNFR-knockout [KO]) and control wild-type (WT) mice, although female TNFR-KO mice showed slightly but significantly higher parasitemia immediately following the peak. Serum inter
Recognition of breast cancer-associated peptides by tumor-reactive, HLA-class I restricted allogeneic cytotoxic T lymphocytes.: Int J Cancer. 1999 May 17;81(4):607-15. Unique Identifier : AIDSLINE MED/99239958; Nguyen T; Naziruddin B; Dintzis S; Doherty GM; Mohanakumar T; Department of Surgery, Washington University School of Medicine,; St. Louis, MO 63110, USA.; Strategies to identify tumor-associated antigens rely on the paradigm that tumor-associated peptides presented in the context of HLA-class I are recognized by the cellular immune system. Approaches to isolate tumor-specific cytotoxic T lymphocytes (CTL) from tumor-infiltrating lymphocytes are difficult because long-te
Atypical cutaneous lymphoproliferative disorder in patients with HIV infection.: Int J Dermatol. 1999 Feb;38(2):111-8. Unique Identifier : AIDSLINE MED/99206377; Friedler S; Parisi MT; Waldo E; Wieczorek R; Sidhu G; Rico MJ; Ronald O. Perelman Department of Dermatology, New York; University, Department of Veterans Affairs Medical Center, New; York, USA.; BACKGROUND: An inflammatory pruritic eruption which is characterized histologically by CD8+, atypical lymphocytes has been described in human immunodeficiency virus (HIV)-infected patients. This disorder has been described as pseudo-Sezary or a cutaneous T cell lymphoma (CTCL)-simulant , however, as these patients
Cutaneous infections by papillomavirus, herpes zoster and Candida albicans as the only manifestation of idiopathic CD4+ T lymphocytopenia.: Int J Dermatol. 1999 Feb;38(2):119-21. Unique Identifier : AIDSLINE MED/99206378; Manchado Lopez P; Ruiz de Morales JM; Ruiz Gonzalez I; Rodriguez Prieto MA; Dermatology Service and the Immunology Unit, Hospital de Leon,; Spain.; BACKGROUND: Selective depletion of CD4+ T lymphocytes is common in both primary and secondary immunodeficiencies. Idiopathic CD4+ T lymphocytopenia (ICL) cases are defined as a persistent CD4+ T lymphocyte count of less than 300x10(6) cells/L and/or less than 20% of the total T-cell count. METHOD: A 40-year-old woman,
Temporal coordination between initiation of HIV (+)-strand DNA synthesis and primer removal.: J Biol Chem. 1999 Apr 16;274(16):11159-69. Unique Identifier : AIDSLINE MED/99214194; Gotte M; Maier G; Onori AM; Cellai L; Wainberg MA; Heumann H; McGill University AIDS Centre, Lady Davis Institute-Jewish; General Hospital, Montreal, Quebec H3T 1E2, Canada.; mgoette@di.ldi.jgh.mcgill.ca; In this study, we have analyzed the interdependence between the polymerase and RNase H active sites of human immunodeficiency virus-1 reverse transcriptase (RT) using an in vitro system that closely mimics the initiation of (+)-strand DNA synthesis. Time course experiments show that RT pauses after addition of the 12t
Evidence of interactions between the nucleocapsid protein NCp7 and the reverse transcriptase of HIV-1.: J Biol Chem. 1999 Apr 16;274(16):11283-8. Unique Identifier : AIDSLINE MED/99214210; Druillennec S; Caneparo A; de Rocquigny H; Roques BP; Departement de Pharmacochimie Moleculaire et Structurale U 266; INSERM-UMR 8600 CNRS, UFR des Sciences Pharmaceutiques et; Biologiques 4, 75270 Paris Cedex 06, France.; The human immunodeficiency virus (HIV-1) nucleocapsid protein NCp7 containing two CX2CX4HX4C-type zinc fingers was proposed to be involved in reverse transcriptase (RT)-catalyzed proviral DNA synthesis through promotion of tRNA3Lys annealing to the RNA primer binding site, improvement of DNA strand transfers, and enha
Full peptide synthesis, purification, and characterization of six Tat variants. Differences observed between HIV-1 isolates from Africa and other continents.: J Biol Chem. 1999 Apr 23;274(17):11473-8. Unique Identifier : AIDSLINE MED/99223456; Peloponese JM Jr; Collette Y; Gregoire C; Bailly C; Campese D; Meurs EF; Olive D; Loret EP; Laboratoire d'Ingenierie des Systemes Macromoleculaires,; Institut de Biologie Structurale et Microbiologie, CNRS UPR 9027,; 31 Chemin Joseph Aiguier, 13402 Marseille, France.; AIDS in Africa is characterized by the equal distribution of mortality between the two genders because of highly virulent human immunodeficiency virus type 1 (HIV-1) strains. The viral protein Tat trans-activates viral gene expression and is essential for HIV-1 replication. We chemically synthesized six different Tat
The three-dimensional structure of a Tn5 transposase-related protein determined to 2.9-A resolution.: J Biol Chem. 1999 Apr 23;274(17):11904-13. Unique Identifier : AIDSLINE PDB/1B7E; Davies DR; Braam LM; Reznikoff WS; Rayment I; Institute for Enzyme Research and Department of Biochemistry,; University of Wisconsin, Madison, Wisconsin 53705, USA.; Transposon Tn5 employs a unique means of self-regulation by expressing a truncated version of the transposase enzyme that acts as an inhibitor. The inhibitor protein differs from the full-length transposase only by the absence of the first 55 N-terminal amino acid residues. It contains the catalytic active site of tra
Morphine synergizes with lipopolysaccharide in a chronic endotoxemia model.: J Neuroimmunol. 1999 Mar 1;95(1-2):107-14. Unique Identifier : AIDSLINE MED/99244126; Roy S; Charboneau RG; Barke RA; Department of Pharmacology, Veterans Administration Medical; Center and University of Minnesota, Minneapolis 55417, USA.; royxx002@gold.tc.umn.edu; Emergent or elective surgical procedures may be complicated by sepsis, resulting in critical illness that can lead to organ failure and death. The opioid drug, morphine is widely used to alleviate pain in post-surgical patients; however, it is well documented that chronic treatment of mice with morphine affects the pr
Lymphocytes delay kinetics of HSV-1 reactivation from in vitro explants of latent infected trigeminal ganglia.: J Neuroimmunol. 1999 Mar 1;95(1-2):126-35. Unique Identifier : AIDSLINE MED/99244128; Noisakran S; Carr DJ; Department of Microbiology, Immunology, and Parasitology, LSU; Medical Center, New Orleans, LA 70112-1393, USA.; A persistent immune response to herpes simplex virus type 1 (HSV-1) is evidenced by the expression of cytokine transcripts along with infiltrating mononuclear cells in the ganglia of latently infected mice. In trigeminal ganglion (TG) explant co-cultures, the presence of nonirradiated or irradiated primed splenocytes
Elevated levels of interleukin-12 and interferon-gamma in patients with human T lymphotropic virus type I-associated myelopathy.: J Neuroimmunol. 1999 Mar 1;95(1-2):185-9. Unique Identifier : AIDSLINE MED/99244135; Furuya T; Nakamura T; Fujimoto T; Nakane S; Kambara C; Shirabe S; Hamasaki S; Motomura M; Eguchi K; First Department of Internal Medicine, Nagasaki University School; of Medicine, Japan.; The levels of interleukin-12 (IL-12) (p70 heterodimer), total IL-12 (p70 heterodimer plus p40 chains), interferon-gamma (IFN-gamma) as Th1 cytokine, and those of interleukin-4 (IL-4) and interleukin-10 (IL-10) as Th2 cytokines in sera and cerebrospinal fluid (CSF) from 22 patients with human T lymphotropic virus type
Proteasome blockers inhibit TNF-alpha release by lipopolysaccharide stimulated macrophages and microglia: implications for HIV-1 dementia.: J Neuroimmunol. 1999 Mar 1;95(1-2):55-64. Unique Identifier : AIDSLINE MED/99244121; Fine SM; Maggirwar SB; Elliott PR; Epstein LG; Gelbard HA; Dewhurst S; Department of Medicine, University of Rochester Medical Center,; NY 14642, USA. steven_fine@urmc.rochester.edu; HIV-1 infection of the central nervous system can cause severe neurologic disease although only microglial cells and brain macrophages are susceptible to productive viral infection. Substances secreted by infected cells are thought to cause disease indirectly. Tumor necrosis factor alpha (TNF-alpha) is one candidate n
Characterization of learning and memory deficits in C57BL/6 mice infected with LP-BM5, a murine model of AIDS.: J Neuroimmunol. 1999 Mar 1;95(1-2):65-72. Unique Identifier : AIDSLINE MED/99244122; Iida R; Yamada K; Mamiya T; Saito K; Seishima M; Nabeshima T; Department of Neuropsychopharmacology and Hospital Pharmacy,; Nagoya University School of Medicine, Japan.; Mice infected with an immunosuppressive murine leukemia virus mixture, LP-BM5 show a profound immunosuppression described as murine acquired immune deficiency syndrome (AIDS). In the present study, we characterized learning and memory deficits in C57BL/6 mice infected with LP-BM5. Spontaneous alternation behavior in a
Interleukin-4 deficiency facilitates development of experimental myasthenia gravis and precludes its prevention by nasal administration of CD4+ epitope sequences of the acetylcholine receptor.: J Neuroimmunol. 1999 Mar 1;95(1-2):73-84. Unique Identifier : AIDSLINE MED/99244123; Karachunski PI; Ostlie NS; Okita DK; Conti-Fine BM; Department of Biochemistry, College of Biological Sciences,; University of Minnesota, St. Paul 55108, USA.; Immunization with acetylcholine receptor (AChR) causes experimental myasthenia gravis (EMG). We investigated EMG in interleukin (IL)-4 knock out B6 (KO) mice, that lack Th2 cells. EMG was more frequent in KO than in wild type B6 mice. KO and B6 mice developed similar amounts of anti-AChR antibodies. They were IgG2a an
T helper cell subset ratios in patients with severe sepsis.: Intensive Care Med. 1999 Jan;25(1):106-9. Unique Identifier : AIDSLINE MED/99158374; Ferguson NR; Galley HF; Webster NR; Academic Unit of Anaesthesia & Intensive Care, Institute of; Medical Sciences, Foresterhill, Aberdeen, UK.; BACKGROUND: T helper 1 (Thl) lymphocytes produce interferon gamma (IFNgamma), favouring cell mediated immunity; Th2 cells secrete interleukin-4 (IL-4), favouring humoral immunity. Cytokines produced in sepsis may effect Th subset predominance and subsequent immune responses. METHODS: We measured Th subsets in ten pati
The use of focus group methodology--with selected examples from sexual health research.: J Adv Nurs. 1999 Apr;29(4):905-13. Unique Identifier : AIDSLINE MED/99234178; Robinson N; Centre for Sexual Health and HIV Studies, Wolfson Institute of; Health Sciences, Thames Valley University, 32-38 Uxbridge Road,; Ealing, London W5 2BS, England. nicky.robinson@tvu.ac.uk; This paper describes in detail the use of the focus group approach in research. The following issues are discussed: when, why and how focus group methods are used, their advantages and disadvantages and how data are analysed. Selected examples from four research studies on sexual health using this methodology are repo
Burnout and AIDS care-related factors in HIV community clinical nurse specialists in the North of England.: J Adv Nurs. 1999 Apr;29(4):984-93. Unique Identifier : AIDSLINE MED/99234188; Hayter M; School of Nursing and Midwifery, University of Sheffield,; Sheffield, UK.; Burnout in Acquired Immune Deficiency Syndrome (AIDS) care nursing is well described in the literature from a hospital based perspective. No studies into the effects of AIDS care and burnout have been carried out within the community setting. A two-stage, mixed method study was carried out. In Stage one 30 Clinical Nu
Emergency department management of occupational exposures to HIV-infected fluids.: Unique Identifier : AIDSLINE MED/99209858; Torbati SS; Guss DA; Department of Emergency Medicine, University of California San; Diego Medical Center, 92103-8676, USA.; The emergency department is where many healthcare workers will seek medical advice and care after a potential exposure to bodily fluids contaminated with the human immunodeficiency virus (HIV). The estimated risk of HIV infection in healthcare workers with percutaneous exposures to HIV-infected blood is estimated at 0
Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal.: J Immunol. 1999 May 1;162(9):5037-40. Unique Identifier : AIDSLINE MED/99244858; Takahashi C; Mittler RS; Vella AT; Department of Microbiology, Oregon State University, Corvallis; 97331, USA.; After recognition of Ag/MHC and ligation of a costimulatory molecule, resting T cells will clonally expand and then delete to very low levels. Previously, it was shown that deletion can be prevented by coinjection of cytokines or proinflammatory agents such as adjuvants. Here, we demonstrate that ligation of 4-1BB blo
Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor.: J Immunol. 1999 May 1;162(9):5041-4. Unique Identifier : AIDSLINE MED/99244859; Hoshino K; Tsutsui H; Kawai T; Takeda K; Nakanishi K; Takeda Y; Akira S; Department of Appropriate Technology Development, Research; Institute, International Medical Center of Japan, Tokyo, Japan.; IL-18 is a proinflammatory cytokine that plays an important role in NK cell activation and Th1 cell response. Recently IL-1R-related protein (IL-1Rrp) has been cloned as the receptor for IL-18. However, the functional role of IL-1Rrp is still controversial due to its low affinity to IL-18 as well as the possibility of
Cutting edge: stable epigenetic inheritance of regional IFN-gamma promoter demethylation in CD44highCD8+ T lymphocytes.: J Immunol. 1999 May 1;162(9):5053-7. Unique Identifier : AIDSLINE MED/99244862; Fitzpatrick DR; Shirley KM; Kelso A; Leukocyte Biology Unit, Queensland Institute of Medical Research,; Joint Transplantation Biology Program, University of Queensland,; Brisbane, Australia. davidFqimr.edu.au; Genomic DNA methylation patterns influence the development and maintenance of function during cellular differentiation. Methylation of regulatory sequences can have long-lasting effects on gene expression if inherited in an epigenetic manner. Recent work suggests that DNA methylation has a regulatory role in different
Emergence of CTL coincides with clearance of virus during primary simian immunodeficiency virus infection in rhesus monkeys.: J Immunol. 1999 May 1;162(9):5127-33. Unique Identifier : AIDSLINE MED/99244873; Kuroda MJ; Schmitz JE; Charini WA; Nickerson CE; Lifton MA; Lord CI; Forman MA; Letvin NL; Division of Viral Pathogenesis, Department of Medicine, Beth; Israel Deaconess Medical Center, Harvard Medical School, Boston,; MA 02215, USA. mkuroda@bidmc.harvard.edu; The CTL response was characterized during primary SIV/macaque (SIVmac) infection of rhesus monkeys to assess its role in containing early viral replication using both an epitope-specific functional and an MHC class I/peptide tetramer-binding assay. The rapid expansion of a single dominant viral epitope-specific CTL po
Orally induced peripheral nonresponsiveness is maintained in the absence of functional Th1 or Th2 cells.: Unique Identifier : AIDSLINE MED/99244875; Shi HN; Grusby MJ; Nagler-Anderson C; Mucosal Immunology Laboratory, Massachusetts General Hospital,; Charlestown 02129, USA.; Intragastric administration of soluble protein Ags results in peripheral tolerance to the fed Ag. To examine the role of cytokine regulation in the induction of oral tolerance, we fed OVA to mice deficient in Th1 (Stat 4-/-) and Th2 (Stat 6-/-) cells and compared their response to that of normal BALB/c controls. We fo
Distribution of cycling T lymphocytes in blood and lymphoid organs during immune responses.: J Immunol. 1999 May 1;162(9):5164-72. Unique Identifier : AIDSLINE MED/99244878; Vasseur F; Le Campion A; Pavlovitch JH; Penit C; Institut National de la Sante et de la Recherche Medicale; Unite 345, Institut Necker, Centre National de la Recherche; Scientifique, Hopital Necker, Paris, France.; Proliferation of murine T lymphocytes in blood, lymph nodes, and spleen was studied in four in vivo stimulation systems, using BrdU pulse-labeling of DNA-synthesizing cells. The T cell response to the superantigen Staphylococcus enterotoxin B (SEB) was studied in detail. Vbeta8+ T cells showed a peak of DNA synthesis
Differential homing commitments of antigen-specific T cells after oral or parenteral immunization in humans.: J Immunol. 1999 May 1;162(9):5173-7. Unique Identifier : AIDSLINE MED/99244879; Kantele A; Zivny J; Hakkinen M; Elson CO; Mestecky J; University of Alabama, Birmingham, AL 35294, USA.; anu.kentele@ksshp.fi; Animal experiments show that lymphocytes activated in the intestine circulate through mesenteric lymph nodes, lymphatics, and blood, returning to the gut. Homing into intestinal lamina propria is mediated by lymphocyte surface homing receptors, mainly the alpha4beta7-integrin. We studied in humans whether intestinal T
A novel approach to visualize polyclonal virus-specific CD8 T cells in vivo.: J Immunol. 1999 May 1;162(9):5178-82. Unique Identifier : AIDSLINE MED/99244880; Zimmermann C; Pircher H; Department of Immunology, Institute for Medical Microbiology and; Hygiene, University of Freiburg, Germany.; Recent technical breakthroughs in generating soluble MHC class I-peptide tetramers now allow the direct visualization of virus-specific CD8 T cells after infection in vivo. However, this technique requires the knowledge of the immunodominant viral epitopes recognized by T cells. Here, we describe an alternative approa