1999
- Isolation of high-molecular-weight genomic DNA from intact biohazardous mammalian tissues.
- Biotechniques. 1999 Jan;26(1):62-4, 66. Unique Identifier : AIDSLINE MED/99111964
- Liska V; Ruprecht RM; Dana-Farber Cancer Institute, Boston, MA 02115-6084, USA.
- Megakaryocyte precursors, megakaryocytes and platelets express the HIV co-receptor CXCR4 on their surface: determination of response to stromal-derived factor-1 by megakaryocytes and platelets.
- Br J Haematol. 1999 Feb;104(2):220-9. Unique Identifier : AIDSLINE MED/99157988
- Kowalska MA; Ratajczak J; Hoxie J; Brass LF; Gewirtz A; Poncz M; Ratajczak MZ; The Children's Hospital of Philadelphia, Pennsylvania 19104, USA.
- Thrombocytopenia is a late complication of human immunodeficiency virus (HIV) infection. The chemokine receptor CXCR4 has been shown to be a co-receptor for lymphocyte-tropic HIV-1 strains. CXCR4 is also a natural receptor for the chemokine SDF-1. We have previously shown that CXCR1 and CXCR2 are present on megakaryoc
- [Characteristics of the carriers of antibodies to hepatitis C virus with normal transaminases levels in HIV infected patients]
- An Med Interna. 1998 Sep;15(9):459-63. Unique Identifier : AIDSLINE MED/99179252
- Ramos Paesa C; Pascual Catalan A; Arazo Garces P; Aguirre Errasti JM; Hermida Lazcano I; Servicio de Medicina Interna, Hospital Miguel Servet, Zaragoza.
- BACKGROUND: To know the characteristics of the carriers of antibodies to hepatitis C virus (HCV) with persistently normal transaminases levels ( carriers ) in coinfected with HIV, the incidence of the real viral activity and the factors that could determine it. PATIENTS AND METHODS: We analyzed 114 patients with crite
- [Viremia levels of the chronic hepatitis c virus in HIV infected patients, clinical implications]
- Unique Identifier : AIDSLINE MED/99179253
- Ramos Paesa C; Pascual Catalan A; Arazo Garces P; Aguirre Errasti JM; Lasierra P
- BACKGROUND: To know the clinical implications of the viremia level and its evolution in time of the hepatitis C virus (HCV) in patients with chronic hepatitis and infected with the Human Immunodeficiency Virus (HIV). PATIENTS AND METHODS: We have studied the viremia level of the HCV in a a 38 patients group with activ
- [Pulmonary lymphomatoid granulomatosis associated with AIDS. Report of a case and review of the literature]
- An Med Interna. 1998 Sep;15(9):487-9. Unique Identifier : AIDSLINE MED/99179259
- Pastrana Delgado J; Conchillo Armendariz MA; Vega Vazquez F; Beloqui Ruiz O; Departamento de Medicina Interna, Clinica Universitaria de; Navarra, Pamplona.
- We present an AIDs patient who was admitted to our hospital because of dry cough, pleuritic chest pain, fever and bilateral lung nodules on the chest X-ray. An open lung biopsy was diagnostic for Lymphomatoid Granulomatosis (GL). We review the literature of the clinical manifestations, anatomopathological and pathogen
- [Pulmonary infection by Mycobacterium xenopi in a patient with positive HIV (letter)]
- An Med Interna. 1998 Sep;15(9):506-7. Unique Identifier : AIDSLINE MED/99179263
- Alberola ML; Roig P; Orti A; Martin C; Cuadrado JM; Merino J
- [Virologic levels for HIV before and after the introduction of protease inhibitors (letter)]
- An Med Interna. 1998 Sep;15(9):508-9. Unique Identifier : AIDSLINE MED/99179265
- Molinero M; Solano C; Gomez-Cano M; Soriano V
- Chemokine and chemokine receptor gene variants and risk of non-Hodgkin's lymphoma in human immunodeficiency virus-1-infected individuals.
- Blood. 1999 Mar 15;93(6):1838-42. Unique Identifier : AIDSLINE MED/99168970
- Rabkin CS; Yang Q; Goedert JJ; Nguyen G; Mitsuya H; Sei S; Viral Epidemiology Branch, HIV and AIDS Malignancy Branch, and; Experimental Retrovirology Section, National Cancer Institute,; Bethesda, MD, USA.
- Normal B-lymphocyte maturation and proliferation are regulated by chemotactic cytokines (chemokines), and genetic polymorphisms in chemokines and chemokine receptors modify progression of human immunodeficiency virus-1 (HIV-1) infection. Therefore, 746 HIV-1-infected persons were examined for associations of previousl
- Human immunodeficiency virus-1-infected macrophages induce inducible nitric oxide synthase and nitric oxide (NO) production in astrocytes: astrocytic NO as a possible mediator of neural damage in acquired immunodeficiency syndrome.
- Blood. 1999 Mar 15;93(6):1843-50. Unique Identifier : AIDSLINE MED/99168971
- Hori K; Burd PR; Furuke K; Kutza J; Weih KA; Clouse KA; Division of Cytokine Biology and the Division of Cellular and; Gene Therapies, Center for Biologics Evaluation and Research,; Food and Drug Administration, Rockville, MD, USA.
- Nitric oxide (NO) plays an important role in normal neural cell function. Dysregulated or overexpression of NO contributes to neurologic damage associated with various pathologies, including human immunodeficiency virus (HIV)-associated neurological disease. Previous studies suggest that HIV-infected monocyte-derived
- Human immunodeficiency virus replication induces monocyte chemotactic protein-1 in human macrophages and U937 promonocytic cells.
- Blood. 1999 Mar 15;93(6):1851-7. Unique Identifier : AIDSLINE MED/99168972
- Mengozzi M; De Filippi C; Transidico P; Biswas P; Cota M; Ghezzi S; Vicenzi E; Mantovani A; Sozzani S; Poli G; AIDS Immunopathogenesis Unit, DIBIT, San Raffaele Scientific; Institute, Milano, Italy.
- We have recently described a significant correlation between human immunodeficiency virus-1 (HIV-1) RNA replication and monocyte chemotactic protein-1 (MCP-1) levels in the cerebrospinal fluid (CSF) of individuals with the acquired immunodeficiency syndrome (AIDS) with HIV encephalitis (E). Because local macrophages (
- Transduction of primitive human marrow and cord blood-derived hematopoietic progenitor cells with adeno-associated virus vectors.
- Blood. 1999 Mar 15;93(6):1882-94. Unique Identifier : AIDSLINE MED/99168976
- Chatterjee S; Li W; Wong CA; Fisher-Adams G; Lu D; Guha M; Macer JA; Forman SJ; Wong KK Jr; Division of Pediatrics, Department of Hematology and Bone Marrow; Transplantation, City of Hope National Medical Center, Duarte,; CA, USA. schatterjee@coh.org
- We evaluated the capacity of adeno-associated virus (AAV) vectors to transduce primitive human myeloid progenitor cells derived from marrow and cord blood in long-term cultures and long-term culture-initiating cell (LTC-IC) assays. Single-colony analyses showed that AAV vectors transduced CD34(+) and CD34(+)38(-) clon
- Human immunodeficiency virus type 1 Vpr alters bone marrow cell function.
- Blood. 1999 Mar 15;93(6):1906-15. Unique Identifier : AIDSLINE MED/99168978
- Kulkosky J; Laptev A; Shetty S; Srinivasan A; BouHamdan M; Prockop DJ; Pomerantz RJ; Dorrance H. Hamilton Laboratories, Center for Human Virology,; Division of Infectious Diseases, Department of Medicine,; Jefferson Medical College, Jefferson University, Philadelphia,; PA, USA.
- Vpr, a 96 amino acid protein, encoded by the human immunodeficiency virus type I (HIV-1), is important for efficient infection of mononuclear phagocytic cells. These cells are abundant in whole bone marrow, which can easily be cultured in vitro to support hematopoiesis. Our experiments indicate that Vpr plays a role i
- CD40-activated B-cell chronic lymphocytic leukemia cells for tumor immunotherapy: stimulation of allogeneic versus autologous T cells generates different types of effector cells.
- Blood. 1999 Mar 15;93(6):1992-2002. Unique Identifier : AIDSLINE MED/99168987
- Buhmann R; Nolte A; Westhaus D; Emmerich B; Hallek M; Laboratorium fur Molekulare Biologie, Genzentrum, Medizinische; Klinik, Grobetahadern, Ludwig-Maximilians-Universitat, Munchen,; Germany.
- Although spontaneous remissions may rarely occur in B-cell chronic lymphocytic leukemia (B-CLL), T cells do generally not develop a clinically significant response against B-CLL cells. Because this T-cell anergy against B-CLL cells may be caused by the inability of B-CLL cells to present tumor-antigens efficiently, we
- The nucleoporin nup153 plays a critical role in multiple types of nuclear export.
- Mol Biol Cell. 1999 Mar;10(3):649-64. Unique Identifier : AIDSLINE MED/99169012
- Ullman KS; Shah S; Powers MA; Forbes DJ; Department of Biology, University of California at San Diego, La; Jolla, California 92093-0347, USA. katharine.ullman@hci.utah.edu
- The fundamental process of nucleocytoplasmic transport takes place through the nuclear pore. Peripheral pore structures are presumably poised to interact with transport receptors and their cargo as these receptor complexes first encounter the pore. One such peripheral structure likely to play an important role in nucl
- Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylation.
- Mol Biol Cell. 1999 Mar;10(3):677-91. Unique Identifier : AIDSLINE MED/99169014
- Pitcher C; Honing S; Fingerhut A; Bowers K; Marsh M; Medical Research Council Laboratory for Molecular Cell Biology; and Department of Biochemistry, University College London, London; WC1E 6BT, United Kingdom.
- Cluster of differentiation antigen 4 (CD4), the T lymphocyte antigen receptor component and human immunodeficiency virus coreceptor, is down-modulated when cells are activated by antigen or phorbol esters. During down-modulation CD4 dissociates from p56(lck), undergoes endocytosis through clathrin-coated pits, and is
- Riluzole: a potential therapy for HIV dementia? [letter]
- Ann Pharmacother. 1999 Jan;33(1):114-5. Unique Identifier : AIDSLINE MED/99138345
- McKinley GF
- Characterization of rash with indinavir in a national patient cohort.
- Ann Pharmacother. 1999 Jan;33(1):17-21. Unique Identifier : AIDSLINE MED/99138326
- Gajewski LK; Grimone AJ; Melbourne KM; Vanscoy GJ; Managed Health Care Division, Stadtlanders Pharmacy, Pittsburgh,; PA 15235, USA.
- OBJECTIVE: To characterize indinavir-associated rash using systematic data collection through postmarketing surveillance in a sample of HIV/AIDS patients. DESIGN: HIV-infected patients identified through a medication counseling line who reported onset of a rash following initiation of indinavir therapy were included i
- Spontaneous remission of hypertrophic lymphocytic gastritis associated with hypoproteinemia.
- Intern Med. 1998 Dec;37(12):1019-22. Unique Identifier : AIDSLINE MED/99129412
- Amenomori M; Umemoto T; Kushima R; Hattori T; Ryuo Medical Center Yuge Clinic, Gamogun, Shiga.
- A 54-year-old woman came to our office because of pretibial edema. She had no gastrointestinal symptoms. Laboratory tests revealed severe hypoproteinemia. Upper gastrointestinal endoscopy demonstrated enlarged gastric folds and multiple aphthoid nodules on the body and the fornix of the stomach. The biopsy specimen re
- An almost-intact human endogenous retrovirus K on human chromosome 7 [letter]
- Nat Genet. 1999 Mar;21(3):257-8. Unique Identifier : AIDSLINE MED/99178257
- Mayer J; Sauter M; Racz A; Scherer D; Mueller-Lantzsch N; Meese E
- Human immunodeficiency virus and the outcome of treatment for new and recurrent pulmonary tuberculosis in African patients.
- Am J Respir Crit Care Med. 1999 Mar;159(3):733-40. Unique Identifier : AIDSLINE MED/99160777
- Murray J; Sonnenberg P; Shearer SC; Godfrey-Faussett P; National Centre for Occupational Health, Department of Health,; Johannesburg, South Africa. jmurray@ncoh.pwv.gov.za
- The purpose of this study was to evaluate the impact of human immunodeficiency virus (HIV) infection on treatment for tuberculosis (TB). The study population comprised 28,522 black Southern African gold miners. Patients with sputum culture-positive new or recurrent pulmonary TB diagnosed in 1995 were prospectively enrv
- An open and closed case for all polymerases.
- Structure. 1999 Feb 15;7(2):R31-5. Unique Identifier : AIDSLINE MED/99148132
- Doublie S; Sawaya MR; Ellenberger T; Department of Microbiology and Molecular Genetics, The Markey; Center for Molecular Genetics, University of Vermont, Burlington,; VT 05405, USA.
- The recently determined structures of HIV-1 reverse transcriptase and Taq DNA polymerase in complex with DNA primer-template and an incoming nucleotide have shown that a large conformational change configures the polymerase active site for nucleotidyl transfer. The structure of reverse transcriptase in the catalytic cv
- Dual conformations for the HIV-1 gp120 V3 loop in complexes with different neutralizing fabs.
- Structure. 1999 Feb 15;7(2):131-42. Unique Identifier : AIDSLINE PDB/2F58
- Stanfield R; Cabezas E; Satterthwait A; Stura E; Profy A; Wilson I; The Scripps Research Institute, Department of Molecular Biology,; 10550 North Torrey Pines Road, La Jolla CA 92037, USA.
- BACKGROUND: The third hypervariable (V3) loop of HIV-1 gp120 has been termed the principal neutralizing determinant (PND) of the virus and is involved in many aspects of virus infectivity. The V3 loop is required for viral entry into the cell via membrane fusion and is believed to interact with cell surface chemokine v
- Biologically active oligodeoxyribonucleotides. Part 11: The least phosphate-modification of quadruplex-forming hexadeoxyribonucleotide TGGGAG, bearing 3-and 5-end-modification, with anti-HIV-1 activity.
- Bioorg Med Chem. 1998 Dec;6(12):2469-75. Unique Identifier : AIDSLINE MED/99122712
- Koizumi M; Koga R; Hotoda H; Ohmine T; Furukawa H; Agatsuma T; Nishigaki T; Abe K; Kosaka T; Tsutsumi S; Sone J; Kaneko M; Kimura S; Shimada K; Exploratory Chemistry Research Lab., Sankyo Co., Ltd, Tokyo,; Japan. koizum@shina.sankyo.co.jp
- We have found that a hexadeoxyribonucleotide (5 TGGGAG3 , R-95288), Koizumi, M. et al. Bioorganic & Medicinal Chemistry, 1997, 5, 2235, bearing a 3,4-dibenzyloxybenzyl (3,4-DBB) group at the 5 -end and a 2-hydroxyethylphosphate at the 3 -end, has high anti-HIV-1 activity and the least cytotoxicity in vitro and in v
- The pattern of neurotransmitter alterations in LP-BM5 infected mice is consistent with glutamatergic hyperactivation.
- Brain Res. 1998 May 18;793(1-2):119-26. Unique Identifier : AIDSLINE MED/98296129
- Kustova Y; Ha JH; Espey MG; Sei Y; Morse D; Basile AS; Laboratory of Bio-Organic Chemistry, NIDDK, National Institutes; of Health, Bethesda, MD 20892, USA.
- To gain insight into the neurochemical pathologies contributing to AIDS dementia complex, neurotransmitter levels were measured in the brains of mice infected with the LP-BM5 leukemia retrovirus. These mice develop immunologic and cognitive deficits analogous to human HIV-1 infecti
- Oxandrolone, used for treatment of wasting disease in HIV-1-infected patients, does not diminish the antiviral activity of deoxynucleoside analogues in lymphocyte and macrophage cell cultures.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):215-9. Unique Identifier : AIDSLINE MED/99174786
- Segal DM; Perez M; Shapshak P; Department of Psychiatry and Behavioral Sciences, Comprehensive; Drug Research Center, University of Miami School of Medicine,; Florida 33136, USA.
- Antiviral agents are the primary therapy for patients infected with HIV-1. However, supportive therapies are often necessary in addition to antiviral drugs because of the devastating wasting process associated with HIV-1 infection and AIDS. Oxandrolone, an anabolic steroid, is used in promoting weight gain and, most i
- Clinical trials using HIV-1 RNA-based primary endpoints: statistical analysis and potential biases.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):220-7. Unique Identifier : AIDSLINE MED/99174787
- Marschner IC; Betensky RA; DeGruttola V; Hammer SM; Kuritzkes DR; Center for Biostatistics in AIDS Research and Department of; Biostatistics, Harvard School of Public Health, Boston,; Massachusetts 02115, USA.
- Clinical trial endpoints based on magnitude of reduction in HIV-1 RNA levels provide an important complement to endpoints based on percentage of patients achieving complete virologic suppression. However, interpretation of magnitude of reduction can be biased by measurement limitations of virologic assays, particularl
- Studies of body composition and fat distribution in HIV-infected and control subjects.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):228-37. Unique Identifier : AIDSLINE MED/99174788
- Kotler DP; Rosenbaum K; Wang J; Pierson RN; Department of Medicine, St. Luke's-Roosevelt Hospital Center,; Columbia University College of Physicians and Surgeons, New York,; New York 10025, USA.
- OBJECTIVE: Recent studies have documented alterations in body fat distribution that have been associated with protease inhibitor therapy. We compared body composition, including measurements of fat distribution, in 96 HIV-infected subjects studied since January 1996 (current HIV), subjects seen prior to January 1996 (
- Stability of cutaneous anergy in women with or at risk for HIV infection. HIV Epidemiology Research Study Group.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):238-44. Unique Identifier : AIDSLINE MED/99174789
- Klein RS; Sobel J; Flanigan T; Smith D; Margolick JB; Department of Medicine, Montefiore Medical Center and Albert; Einstein College of Medicine, Bronx, New York 10467, USA.
- OBJECTIVE: To study the stability of cutaneous anergy in women with or at risk for HIV infection. DESIGN: Prospective multicenter cohort study METHODS: Interviews, CD4+ lymphocyte counts, and intradermal skin testing with mumps, Candida, and tetanus toxoid antigens were performed on two occasions at a median interval
- Phase II, randomized, open-label, community-based trial to compare the safety and activity of combination therapy with recombinant interferon-alpha2b and zidovudine versus zidovudine alone in patients with asymptomatic to mildly symptomatic HIV infection. HIV Protocol C91-253 Study Team.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):245-54. Unique Identifier : AIDSLINE MED/99174790
- Krown SE; Aeppli D; Balfour HH Jr; Department of Medicine, Memorial Sloan-Kettering Cancer Center; and Cornell University Medical College, New York, New York 10021,; USA.
- OBJECTIVES: To compare, in a community-based therapeutic setting, the safety, tolerance, and efficacy of combination therapy with recombinant interferon-alpha2b (rIFN-alpha2b) and zidovudine (ZDV) to ZDV monotherapy. DESIGN: Open-label, two-armed, randomized study. PAT
- Lack of association between hepatitis C infection and development of AIDS-related lymphoma.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):255-8. Unique Identifier : AIDSLINE MED/99174791
- Levine AM; Nelson R; Zuckerman E; Zuckerman T; Govindarajan S; Valinluck B; Bernstein L; Department of Medicine, University of Southern California School; of Medicine, Los Angeles 90033, USA. hornor@hsc.usc.edu
- Hepatitis C virus (HCV) has been associated with various lymphoproliferative disorders, and a high prevalence (9%-32%) of chronic HCV infection has been demonstrated among patients with lymphoma. Dual coinfection by HIV and HCV has been demonstrated in approximately 40% of certain populations of HIV-infected individua
- HIV infection of the central nervous system is characterized by rapid turnover of viral RNA in cerebrospinal fluid.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):259-64. Unique Identifier : AIDSLINE MED/99174792
- Eggers CC; van Lunzen J; Buhk T; Stellbrink HJ; Neurologische Klinik, Universitatskrankenhaus Eppendorf,; Hamburg, Germany. eggers@uke.uni-hamburg.de
- To assess the kinetics of viral replication and decay in cerebrospinal fluid (CSF), we studied the short-term effects of highly active antiretroviral therapy (HAART) on CSF HIV-1 RNA concentrations. In 15 HIV-positive patients, HIV RNA concentrations were measured in paired CSF and plasma/serum samples. Samples were o
- Impact of tuberculosis on the body composition of HIV-infected men in Brazil.
- Unique Identifier : AIDSLINE MED/99174793
- Paton NI; Castello-Branco LR; Jennings G; Ortigao-de-Sampaio MB; Elia M; Costa S; Griffin GE; St. George's Hospital Medical School, Tooting, London, UK.; Paton_NIJ@notes.ttsh.gov.sg
- OBJECTIVE: Tuberculosis (TB) is the commonest HIV-related opportunistic infection in many developing countries and is thought to be a frequent underlying cause of HIV-associated wasting. We have used reference water dilution methods to examine the body composition changes associated with TB and to assess the severity
- Psychoactive drug use and progression of HIV infection.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):272-4. Unique Identifier : AIDSLINE MED/99174794
- Des Jarlais DC; Beth Israel Medical Center, New York City, New York 10003, USA.
- Early in the history of the AIDS epidemic there was clear evidence of differences in the outcomes of HIV infection between injecting drug users and men who have sex with men. There were also some indications that high levels of nonsterile drug injection may increase the progression of HIV infection. Recent epidemiolog
- Direct comparison of time to AIDS and infectious disease death between HIV seroconverter injection drug users in Italy and the United States: results from the ALIVE and ISS studies. AIDS Link to Intravenous Experiences. Italian Seroconversion Study.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):275-82. Unique Identifier : AIDSLINE MED/99174795
- Pezzotti P; Galai N; Vlahov D; Rezza G; Lyles CM; Astemborski J; Centro Operativo AIDS, Istituto Superiore di Sanita, Rome,; Italy. Patrizio.Pezzotti@iss.it
- OBJECTIVE: To compare the rate of HIV disease progression in a sample of polydrug injectors (AIDS Link to Intravenous Experiences [ALIVE] study) with that in a sample of predominantly opiate injectors (Italian Seroconversion Study [ISS]). DESIGN: Prospective cohort studies of HIV-positive individuals whose date of ser
- Incidence of discontinuation of highly active antiretroviral combination therapy (HAART) and its determinants.
- Unique Identifier : AIDSLINE MED/99174797
- van Roon EN; Verzijl JM; Juttmann JR; Lenderink AW; Blans MJ; Egberts AC
- OBJECTIVE: To determine the incidence and determinants for discontinuation of initial highly active antiretroviral therapy (HAART). DESIGN: In this retrospective follow-up study from hospital files and pharmacy dispensing data, a standard dataset was collected including patient characteristics, therapy characteristics
- Incidence and risk factors for heterosexually acquired HIV in an inner-city cohort of women: temporal association with pregnancy.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):295-9. Unique Identifier : AIDSLINE MED/99174798
- Chirgwin KD; Feldman J; Dehovitz JA; Minkoff H; Landesman SH; Department of Medicine, State University of New York, Health; Sciences Center at Brooklyn, USA.
- BACKGROUND: A growing proportion of AIDS cases in the United States are due to heterosexual transmission of HIV, particularly in women. The risk of heterosexually acquired HIV was prospectively studied in a cohort of inner-city women with no history of parenteral drug use. METHODS: Stu
- Cervical dysplasia on cervicovaginal Papanicolaou smear among HIV-1-infected pregnant and nonpregnant women. Women and Infants Transmission Study.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):300-7. Unique Identifier : AIDSLINE MED/99174799
- Stratton P; Gupta P; Riester K; Fox H; Zorrilla C; Tuomala R; Eriksen N; Vajaranant M; Minkoff H; Fowler MG; National Institute of Child Health and Human Development,; Bethesda, Maryland 20982-1862, USA. Pamela_Stratton@nih.gov
- OBJECTIVE: To assess the association of squamous intraepithelial lesions (SIL) on cervicovaginal Papanicolaou (Pap) smear among women infected with HIV-1 and their pregnancy status, and historical and clinical factors. METHODS: Study enrollment Pap smears of 452 pregnant and 126 nonpregnant HIV-infected women had cyto
- Evaluation of behavioral and social issues among Thai HIV vaccine trial volunteers.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):308-14. Unique Identifier : AIDSLINE MED/99174800
- Thapinta D; Jenkins RA; Celentano DD; Nitayaphan S; Buapunth P; Triampon A; Morgan PA; Khamboonruang C; Suwanarach C; Yutabootr Y; Ruckphaopunt S; Suwankiti S; Tubtong V; Cheewawat W; McNeil JG; Michael RA; Faculty of Nursing, Research Institute of Health Sciences, Chiang; Mai University, Thailand.
- Behavioral and social issues were investigated in phase I/II preventive HIV vaccine trial volunteers in Thailand . These included risk behavior, HIV knowledge, distress, and social experiences associated with trial participation. Data were collected at baseline and at 4- and 8-mon
- Few clues for AIDS vaccines from structural data on gp120 and its receptors and antibodies [letter]
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):315-6. Unique Identifier : AIDSLINE MED/99174801
- Kohler H; Muller S; Schiffer M; Nara PL
- Recent dramatic decrease in AIDS cases and HIV-related deaths contrasts with stable rate of new HIV-positive patients detected in Lyon, France, from 1988 to 1997 [letter]
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Mar 1;20(3):316-7. Unique Identifier : AIDSLINE MED/99174802
- Vanhems P; Baratin D; Trepo C; Peyramond D; Touraine JL; Marceillac E; Fabry J
- Development of a Western blot assay for detection of bovine immunodeficiency-like virus using capsid and transmembrane envelope proteins expressed from recombinant baculovirus.
- Clin Diagn Lab Immunol. 1999 Mar;6(2):168-72. Unique Identifier : AIDSLINE MED/99167659
- Abed Y; St-Laurent G; Zhang H; Jacobs RM; Archambault D; Departement des Sciences Biologiques, Universite du Quebec a; Montreal, Montreal, Quebec, Canada.
- A 120-amino-acid polypeptide selected from the transmembrane protein region (tTM) and the major capsid protein p26 of bovine immunodeficiency-like virus (BIV) were expressed as fusion proteins from recombinant baculoviruses. The antigenic reactivity of both recombinant fusion proteins was confirmed by Western blot wit
- Protection against influenza virus infection of mice fed Bifidobacterium breve YIT4064.
- Clin Diagn Lab Immunol. 1999 Mar;6(2):186-92. Unique Identifier : AIDSLINE MED/99167663
- Yasui H; Kiyoshima J; Hori T; Shida K; Yakult Central Institute for Microbiological Research and; Department of Microbiology, 1796 Yaho, Kunitachi-shi, Tokyo; 186-8650, Japan.
- Mice fed Bifidobacterium breve YIT4064 and immunized orally with influenza virus were more strongly protected against influenza virus infection of the lower respiratory tract than ones immunized with influenza virus only. The number of mice with enhanced anti-influenza virus immunoglobulin G (IgG) in serum upon oral a
- Increased expression of regeneration and tolerance factor in individuals with human immunodeficiency virus infection.
- Clin Diagn Lab Immunol. 1999 Mar;6(2):193-8. Unique Identifier : AIDSLINE MED/99167664
- DuChateau BK; Lee GW; Westerman MP; Beaman KD; Clinical Immunology Laboratory and Department of; Microbiology/Immunology, Finch University of Health Sciences/The; Chicago Medical School, North Chicago, Illinois 60064, USA.
- Regeneration and tolerance factor (RTF) plays a pivotal role in successful pregnancy outcome and has potent immunomodulating properties. During pregnancy, it is abundantly expressed in the placenta and on peripheral B lymphocytes. Several lines of evidence suggest that both successful pregnancy outcome and progression
- A powerful DNA extraction method and PCR for detection of microsporidia in clinical stool specimens.
- Clin Diagn Lab Immunol. 1999 Mar;6(2):243-6. Unique Identifier : AIDSLINE MED/99167672
- Muller A; Stellermann K; Hartmann P; Schrappe M; Fatkenheuer G; Salzberger B; Diehl V; Franzen C; Department of Internal Medicine I, University of Cologne, D-50924; Cologne, Germany.
- The diagnosis of intestinal microsporidiosis has traditionally depended on direct visualization of the parasite in stool specimens or intestinal biopsy samples by light and/or electron microscopy. Limited information about the specificity and sensitivity of PCR for the
- Predictive value of CD19 measurements for bacterial infections in children infected with human immunodeficiency virus.
- Clin Diagn Lab Immunol. 1999 Mar;6(2):247-53. Unique Identifier : AIDSLINE MED/99167673
- Betensky RA; Calvelli T; Pahwa S; Department of Biostatistics, Harvard School of Public Health,; Boston, Massachusetts 02115, USA. betensky@hsph.harvard.edu
- We investigated the predictive value of CD19 cell percentages (CD19%) for times to bacterial infections, using data from six pediatric AIDS Clinical Trials Group protocols and adjusting for other potentially prognostic variables, such as CD4%, CD8%, immunoglobulin (IgA) level, lymphocyte count, prior infections, prior
- Antenatal screening for HIV in the UK: what is to be done? [editorial]
- J Med Screen. 1998;5(4):170-1. Unique Identifier : AIDSLINE MED/99133408
- Nicoll A
- Performance of antenatal HIV screening strategies in the UK: correction [letter]
- J Med Screen. 1998;5(4):214. Unique Identifier : AIDSLINE MED/99133417
- Tookey P; Gibb D; Ades T
- Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides.
- Chem Biol. 1999 Feb;6(2):111-6. Unique Identifier : AIDSLINE MED/99147129
- Marx A; Spichty M; Amacker M; Schwitter U; Hubscher U; Bickle TA; Maga G; Giese B; Department of Chemistry, University of Basel, Switzerland.
- BACKGROUND: To gain a molecular understanding of a biochemical process, the crystal structure of enzymes that catalyze the reactions involved is extremely helpful. Often the question arises whether conformations obtained in this way appropriately reflect the reactivity of enzymes, however. Rates that characterize tran
- Safety profile of nevirapine, a nonnucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus infection.
- Clin Ther. 1998 Nov-Dec;20(6):1071-92. Unique Identifier : AIDSLINE MED/99113641
- Pollard RB; Robinson P; Dransfield K; University of Texas Medical Branch, Galveston 77555-0835, USA.
- Nevirapine (NVP) is a nonnucleoside reverse transcriptase inhibitor widely used in combination with other antiretroviral agents for the treatment of human immunodeficiency virus disease. To establish its safety profile, we conducted a review of data from prospective US and international clinical trials involving a tot
- Transverse 1H cross relaxation in 1H-15N correlated 1H CPMG experiments.
- J Magn Reson. 1999 Mar;137(1):289-92. Unique Identifier : AIDSLINE MED/99164243
- Ishima R; Louis JM; Torchia DA; Molecular Structural Biology Unit, National Institute of Dental; and Craniofacial Research, Bethesda, Maryland, 20892-4326, USA.
- Transverse 1H cross relaxation was observed in Carr-Purcell-Meiboom-Gill (CPMG) experiments by recording 15N-1H correlated spectra of amides in HIV protease that was perdeuterated at nonexchangeable sites. Perdeuteration suppresses 1H-1H J coupling and improves spectral resolution and sensitivity. Measurements of cros
- Canada's drug problem: time to get serious [letter]
- CMAJ. 1999 Feb 23;160(4):477, 479. Unique Identifier : AIDSLINE MED/99181301
- Voth EA
- Credit for discoveries: citation data as a basis for history of science analysis.
- Theor Med Bioeth. 1998 Dec;19(6):609-20. Unique Identifier : AIDSLINE MED/99160945
- Lindahl BI; Elzinga A; Welljams-Dorof A; Department of Philosophy, Stockholm University, Sweden.
- Citation data have become an increasingly significant source of information for historians, sociologists, and other researchers studying the evolution of science. In the past few decades elaborate methodologies have been developed for the use of citation data in the study of the modern history of science. This article
- Human milk glycoconjugates that inhibit pathogens.
- Unique Identifier : AIDSLINE MED/99128419
- Newburg DS
- Breast-fed infants have lower incidence of diarrhea, respiratory disease, and otitis media. The protection by human milk has long been attributed to the presence of secretory IgA. However, human milk contains large numbers and amounts of complex carbohydrates, including glycoproteins, glycolipids, glycosaminoglycans,
- Immunomodulatory effects of tretinoin in combination with clindamycin.
- J Eur Acad Dermatol Venereol. 1998 Sep;11 Suppl 1:S2-7; discussion S28-9. Unique Identifier : AIDSLINE MED/99109051
- Wauben-Penris PJ; Cerneus DP; van den Hoven WE; Leuven PJ; den Brok JH; Hall DW; Yamanouchi Europe B.V. Research Laboratories, Leiderdorp, The; Netherlands. wauben.nl@yamanouchi-eu.com
- BACKGROUND: Since acne is a multifactorial skin disease, therapies affecting several etiologic factors can have a higher than expected effectiveness. A combination of the antibiotic clindamycin phosphate and the retinoic acid tretinoin was developed. OBJECTIVE: Anti-inflammatory and immunomodulatory effects of tretino
- Health care utilization and survival among patients with AIDS in Belo Horizonte, Minas Gerais, Brazil.
- Cad Saude Publica. 1998 Oct-Dec;14(4):811-20. Unique Identifier : AIDSLINE MED/99147188
- Acurcio F de A; Cesar CC; Guimaraes MD; Departamento de Farmacia Social e Curso de Doutorado em Ciencia; Animal, Universidade Federal de Minas Gerais, Av. Olegario; Maciel 2360, Belo Horizonte, MG 30180-112, Brasil.
- A historical cohort study was conducted in three public AIDS referral services in Belo Horizonte, Minas Gerais, to assess the relationship between health care utilization and patient survival following AIDS diagnosis. A review of medical and laboratory records was performed for HIV-infected patients seeking care for t
- Synthesis and biological evaluation of a carbocyclic azanoraristeromycin siderophore conjugate.
- Nucleosides Nucleotides. 1999 Feb;18(2):217-25. Unique Identifier : AIDSLINE MED/99166246
- Ghosh A; Miller MJ; De Clercq E; Balzarini J; Department of Chemistry and Biochemistry, University of Notre; Dame, IN 46556, USA.
- Synthesis and biological evaluation of a carbocyclic azanoraristeromycin siderophore conjugate 22 is reported. Coupling of previously prepared L-alanyl-4 -azanoraristeromycin 19 with protected tripeptide trihydroxamate 20, followed by hydrogenolytic removal of all protecting groups, provided the first carbocylic azano
- Synthesis of a new class of HIV-1 inhibitors.
- Nucleosides Nucleotides. 1999 Feb;18(2):263-75. Unique Identifier : AIDSLINE MED/99166248
- Farese-Di Giorgio A; Pairot S; Patino N; Condom R; Di Giorgio C; Aumelas A; Aubertin AM; Guedj R; Laboratoire de Chimie Bio-Organique, CNRS ESA 6001, Universite; de Nice Sophia-Antipolis, France.
- A new family of molecules potentially inhibitors of the HIV-1 Tat-TAR complex was prepared. These compounds are constituted by dinucleotide analogs (PNA dimer) bound, through a linker, to an arginine residue. In this series, several molecules inhibit viral development in cell culture with a micromolar IC50 and without
- Antibody-dependent cell-mediated cytotoxicity can protect PBMC from infection by cell-associated HIV-1.
- 1999 Feb;90(2):203-12. Unique Identifier : AIDSLINE MED/99180792
- Hildreth JEK; Hampton R; Halsey NA; Department of Pharmacology and Molecular Sciences, The Johns; Hopkins University School of Medicine, Baltimore, Maryland 21205,; USA.
- We have developed a novel in vitro assay system to study the role of antibody-dependent cell-mediated cytotoxicity (ADCC) in protection against HIV-1 infection by cell-associated virus. HIV-1-infected NK-resistant cells are mixed with specific antibody and unstimulated PBMC and ADCC is allowed to occur over several ho
- Role of cytomegalovirus in the T cell changes seen in elderly individuals.
- 1999 Feb;90(2):213-9. Unique Identifier : AIDSLINE MED/99180793
- Looney RJ; Falsey A; Campbell D; Torres A; Kolassa J; Brower C; McCann R; Menegus M; McCormick K; Frampton M; Hall W; Abraham GN; Department of Medicine, University of Rochester, Rochester, New; York 14642, USA.
- The effect of prior cytomegalovirus ( CMV ) infection on the immune system was evaluated in young and elderly volunteers. Prevalence of IgG antibodies to CMV was higher in the elderly volunteers. In both age groups, there was a
- Evaluation of lymphocytic responses after treatment with Bacillus Calmette-Guerin and interferon-alpha 2b for superficial bladder cancer.
- 1999 Feb;90(2):230-7. Unique Identifier : AIDSLINE MED/99180795
- Gan YH; Mahendran R; James K; Lawrencia C; Esuvaranathan K; Department of Surgery, National University of Singapore,; Singapore.
- Bladder wash-derived lymphocytes from superficial bladder cancer patients involved in high dose BCG, low dose BCG, and low dose BCG with IFN-alpha treatments were examined. We found an increasing trend in the percentage of CD3 T cells with each weekly intravesical instillation and the proportion of CD3 T cells express
- The prognostic significance in HIV infection of immune activation represented by cell surface antigen and plasma activation marker changes.
- 1999 Feb;90(2):238-46. Unique Identifier : AIDSLINE MED/99180796
- Plaeger S; Bass HZ; Nishanian P; Thomas J; Aziz N; Detels R; King J; Cumberland W; Kemeny M; Fahey JL; Center for Interdisciplinary Research in Immunology and Disease; (CIRID) and the Jonsson Comprehensive Cancer Center, UCLA School; of Medicine, Los Angeles, California, 90095, USA.
- One hundred and eighteen HIV-infected homosexual men without AIDS and 40 control seronegative homosexual men were assessed for 23 parameters reflecting immune activation to determine prognostic significance for occurrence of AIDS. Samples cryopreserved in 1987-1989 were analyzed, with AIDS occurrence determined by mid
- C1q autoantibodies in HIV infection: correlation to elevated levels of autoantibodies against 60-kDa heat-shock proteins.
- 1999 Feb;90(2):247-55. Unique Identifier : AIDSLINE MED/99180797
- Prohaszka Z; Daha MR; Susal C; Daniel V; Szlavik J; Banhegyi D; Nagy K; Varkonyi V; Horvath A; Ujhelyi E; Toth FD; Uray K; Hudecz F; Fust G; Third Department of Medicine, Semmelweis Medical University,; Budapest, Hungary.
- Antibodies to solid phase C1q (C1qAb) were determined in 295 serum samples from 132 HIV-infected subjects and in sera from 140 HIV-seronegative healthy individuals as control. An ELISA method applied for the determination of C1qAb in other diseases was used. In part of these sera, other autoantibodies (antibodies reac
- Progression to type 1 diabetes is associated with a change in the immunoglobulin isotype profile of autoantibodies to glutamic acid decarboxylase (GAD65). Childhood Diabetes in Finland Study Group.
- 1999 Feb;90(2):276-81. Unique Identifier : AIDSLINE MED/99180800
- Petersen JS; Kulmala P; Clausen JT; Knip M; Dyrberg T; Novo-Nordisk A/S, Bagsvaerd, DK-2880, Denmark. jspe@NOVO.DK
- To investigate whether type 1 diabetes in man is associated with a preferential Th1/Th2 response, and whether autoantibodies to one of the main autoantigens would reflect such a response, we characterized the immunoglobulin isotype profile to the 65-kDa isoform of glutamic acid decarboxylase (GAD65) in siblings to IDD
- Cardiac and autonomic evaluation in a pediatric population with human immunodeficiency virus.
- Clin Cardiol. 1999 Jan;22(1):33-6. Unique Identifier : AIDSLINE MED/99128614
- Plein D; Van Camp G; Cosyns B; Alimenti A; Levy J; Vandenbossche JL; Saint Pierre University Hospital, Cardiology Department,; Brussels, Belgium.
- BACKGROUND: Cardiac involvement in children with human immunodeficiency virus (HIV) infection is a well-known entity and occurs clinically more often in patients with advanced acquired immunodeficiency syndrome (AIDS). Autonomic dysfunction is less known, especially in children. HYPOTHESIS: The aim of this study was t
- Molecular epidemiology and antifungal susceptibility of Cryptococcus neoformans isolates from Ugandan AIDS patients.
- Diagn Microbiol Infect Dis. 1998 Nov;32(3):191-9. Unique Identifier : AIDSLINE MED/99100573
- Pfaller M; Zhang J; Messer S; Tumberland M; Mbidde E; Jessup C; Ghannoum M; Department of Pathology, University of Iowa College of Medicine,; Iowa City 52242, USA.
- Little is known of the antifungal susceptibility patterns and molecular epidemiology of Cryptococcus neoformans from tropical regions. We studied 164 clinical isolates of C. neofomans from 120 Ugandan AIDS patients with cryptococcal meningitis by analyzing their electrophoretic karyotypes and antifungal susceptibility
- Azole resistance among oral Candida species isolates from AIDS patients under ketoconazole exposure.
- Diagn Microbiol Infect Dis. 1998 Nov;32(3):211-6. Unique Identifier : AIDSLINE MED/99100576
- Milan EP; Burattini MN; Kallas EG; Fischmann O; Costa PR; Colombo AL; Division of Infectious Diseases, Escola Paulista de Medicina,; Universidade Federal de Sao Paulo, Brazil.
- This is a prospective study designed to investigate species distribution and azole susceptibility profile among Candida spp. isolated from the oral cavities of AIDS patients. One hundred thirty-two AIDS patients sequentially admitted at a teaching tertiary care hospital were enrolled in this study. Samples were obtain
- Kluyvera cryocrescens finger infection: case report and review of eighteen Kluyvera infections in human beings.
- Diagn Microbiol Infect Dis. 1998 Nov;32(3):237-41. Unique Identifier : AIDSLINE MED/99100580
- West BC; Vijayan H; Shekar R; Department of Medicine, Meridia Huron Hospital, Cleveland, Ohio; 44112, USA.
- We report a case of soft tissue infection with Kluyvera cryocrescens and a critical review of Kluyvera infections. A 31-year-old diabetic man used a new chemical for stripping the floor with his bare hands. Two days later he developed a blister on a finger which progressed to tenosynovitis in spite of intravenous nafc
- Assignment of the human endogenous retrovirus S71 (SSAV1) to chromosome 18 band q12.3 by radiation hybrid mapping.
- Cytogenet Cell Genet. 1998;83(3-4):207. Unique Identifier : AIDSLINE MED/99172088
- Kim HS; Crow TJ; Department of Psychiatry, Warneford Hospital, University of; Oxford, Oxford, UK.
- Neither dapsone hydroxylation nor cortisol 6beta-hydroxylation detects the inhibition of CYP3A4 by HIV-1 protease inhibitors.
- Eur J Clin Pharmacol. 1998 Nov-Dec;54(9-10):741-7. Unique Identifier : AIDSLINE MED/99120453
- Gass RJ; Gal J; Fogle PW; Detmar-Hanna D; Gerber JG; Department of Medicine, University of Colorado Health Sciences; Center, Denver 80262, USA.
- OBJECTIVE: This study examined the use of dapsone N-hydroxylation and cortisol 6beta-hydroxylation, well accepted in vivo probes of cytochrome P4503A4 (CYP3A4) activity, on defining the effect of three HIV protease inhibitors on CYP3A4 activity. METHODS: Subjects fr
- Inhibition of nucleoside diphosphate kinase in rat liver mitochondria by added 3'-azido-3'-deoxythymidine.
- FEBS Lett. 1999 Feb 12;444(2-3):291-5. Unique Identifier : AIDSLINE MED/99158064
- Valenti D; Barile M; Quagliariello E; Passarella S; Dipartimento di Biochimica e Biologia Molecolare, Universita di; Bari, and Centro di Studi sui Mitocondri e Metabolismo; Energetico, C.N.R., Italy. d.valenti@biologia.uniba.it
- The effect of 3 -azido-3 -deoxythymidine on nucleoside diphosphate kinase of isolated rat liver mitochondria has been studied. This is done by monitoring the increase in the rate of oxygen uptake by nucleoside diphosphate (TDP, UDP, CDP or GDP) addition to mitochondria in state 4. It is shown that 3 -azido-3 -deoxythy
- Enhancement by vasoactive intestinal peptide of gamma-interferon production by antigen-stimulated type 1 helper T cells.
- Unique Identifier : AIDSLINE MED/99138717
- Jabrane-Ferrat N; Bloom D; Wu A; Li L; Lo D; Sreedharan SP; Turck CW; Goetzl AE; Departments of Medicine and Microbiology-Immunology, University; of California Medical Center, San Francisco, California; 94143-0711, USA.
- Vasoactive intestinal peptide (VIP) is a neuroendocrine mediator in immune tissues that affects many T cell functions through two homologous high-affinity G-protein-coupled receptors, termed VIPR1 and VIPR2. Antigen-stimulated secretion of gamma-interferon (IFN-gamma) by sperm whale myoglobin-specific Th1 cells of DBA
- Antioxidant defenses influence HIV-1 replication and associated cytopathic effects.
- Free Radic Biol Med. 1998 Jun;24(9):1485-91. Unique Identifier : AIDSLINE MED/98302969
- Sandstrom PA; Murray J; Folks TM; Diamond AM; HIV/Retrovirus Disease Branch, Division of AIDS, STD and TB; Laboratory Research, National Center for Infectious Disease,; Centers for Disease Control and Prevention, Atlanta, GA, USA.
- HIV-infected cells often exhibit reduced levels of antioxidant enzymes and thiols. To investigate the role of cellular antioxidant defenses in the progression of an acutely spreading HIV-1 infection, human Sup-T1 T cells were engineered to overexpress the selenium-dependent glutathione peroxidase, GSHPx-1. This enzyme
- Role of reactive oxygen species and poly-ADP-ribose polymerase in the development of AZT-induced cardiomyopathy in rat.
- Free Radic Biol Med. 1999 Feb;26(3-4):309-17. Unique Identifier : AIDSLINE MED/99110512
- Szabados E; Fischer GM; Toth K; Csete B; Nemeti B; Trombitas K; Habon T; Endrei D; Sumegi B; Department of Biochemistry, University Medical School Pecs,; Hungary.
- The short term cardiac side-effects of AZT (3 -azido-3 -deoxythymidine, zidovudine) was studied in rats to understand the biochemical events contributing to the development of AZT-induced cardiomyopathy. Developing rats were treated with AZT (50 mg/kg
- The complexity of pregnancy anemia in Dar-es-Salaam.
- Gynecol Obstet Invest. 1999;47(2):76-82. Unique Identifier : AIDSLINE MED/99135965
- Massawe SN; Urassa EN; Mmari M; Ronquist G; Lindmark G; Nystrom L; Department of Obstetrics and Gynaecology, Muhimbili Medical; Centre, Dar-es-Salaam, Tanzania.
- OBJECTIVES: To investigate the main causes of anemia in pregnancy in Dar-es-Salaam and identify appropriate investigations at all levels of care. MATERIALS: All pregnant women booking for antenatal care at 2 clinics (n = 2,235) were screened for anemia. Investigations for etiology of anemia were done in all anemic wom
- Liver-associated lymphocytes expressing NK1.1 are essential for oral immune tolerance induction in a murine model.
- Hepatology. 1999 Mar;29(3):746-55. Unique Identifier : AIDSLINE MED/99162365
- Trop S; Samsonov D; Gotsman I; Alper R; Diment J; Ilan Y; Liver Unit, Division of Medicine, Hadassah University Hospital,; Jerusalem, Israel.
- Oral tolerance is the induction of immunological hyporesponsiveness towards orally administered antigens. Tolerance initiation involves induction of anti-inflammatory (Th2) lymphocytes, with downregulation of pro-inflammatory (Th1) lymphocytes. The liver was previously shown to play a critical role in oral tolerance i
- Efficacy of lamivudine in patients with hepatitis B e antigen-negative/hepatitis B virus DNA-positive (precore mutant) chronic hepatitis B.Lamivudine Precore Mutant Study Group.
- Hepatology. 1999 Mar;29(3):889-96. Unique Identifier : AIDSLINE MED/99162383
- Tassopoulos NC; Volpes R; Pastore G; Heathcote J; Buti M; Goldin RD; Hawley S; Barber J; Condreay L; Gray DF; Western Attica General Hospital, Athens, Greece.
- This placebo controlled, double-blind study evaluated the efficacy and safety of lamivudine in patients with hepatitis B e antigen (HBeAg)-negative/hepatitis B virus (HBV) DNA-positive chronic hepatitis B. Patients were randomized to receive 100 mg lamivudine orally once daily for 52 weeks (n = 60) or placebo for 26 w
- Viral load and clinicopathological features of chronic hepatitis C (1b) in a homogeneous patient population.
- Hepatology. 1999 Mar;29(3):904-7. Unique Identifier : AIDSLINE MED/99162385
- Fanning L; Kenny E; Sheehan M; Cannon B; Whelton M; O'Connell J; Collins JK; Shanahan F; Department of Medicine, National University of Ireland, Cork,; University College Cork, Ireland. L.FANNING@UCCE.IE
- Monitoring the progression of hepatitis C virus (HCV) includes clinical, biochemical, and histological parameters. Quantitation of viral load by reverse-transcription polymerase chain reaction (RT-PCR) may offer a more reliable marker of disease status. Conflicting reports on viral titers may reflect heterogeneity of
- YMDD motif in hepatitis B virus DNA polymerase influences on replication and lamivudine resistance: A study by in vitro full-length viral DNA transfection.
- Hepatology. 1999 Mar;29(3):939-45. Unique Identifier : AIDSLINE MED/99162390
- Ono-Nita SK; Kato N; Shiratori Y; Masaki T; Lan KH; Carrilho FJ; Omata M; Second Department of Internal Medicine, Faculty of Medicine,; University of Tokyo, Tokyo, Japan.
- Recently, lamivudine used to treat patients with hepatitis B virus (HBV) infection was revealed to have potent antiviral activity. However, HBV resistance to lamivudine has been reported and shown to have amino acid substitutions in the methionine residue of the conserved tyrosine (Y), methionine (M), aspartate (D), a
- Zidovudine (AZT) causes an oxidation of mitochondrial DNA in mouse liver.
- Hepatology. 1999 Mar;29(3):985-7. Unique Identifier : AIDSLINE MED/99162396
- de la Asuncion JG; del Olmo ML; Sastre J; Pallardo FV; Vina J; Departamento de Fisiologia, Facultad de Medicina, Universidad de; Valencia, Valencia, Spain.
- Zidovudine (3 -azido-2 ,3 -dideoxythymidine [ AZT ]) inhibits human immunodeficiency virus replication and delays progression of acquired immune deficiency syndrome. We have recently found that, in muscle, AZT causes oxidative damage to mitochondrial DN
- Mother-infant hepatitis C transmission: second generation research.
- Hepatology. 1999 Mar;29(3):992-3. Unique Identifier : AIDSLINE MED/99162399
- Thomas DL; Johns Hopkins Medical Institutions, Baltimore, MD, USA.
- Human T-cell leukemia virus type 1 can infect a wide variety of cells in mice.
- Jpn J Cancer Res. 1999 Jan;90(1):48-54. Unique Identifier : AIDSLINE MED/99175860
- Feng R; Tanaka M; Abe H; Arashi N; Sun B; Uchida K; Miwa M; Department of Biochemistry and Molecular Oncology, University of; Tsukuba, Ibaraki.
- Analysis of human T-cell leukemia virus type 1 (HTLV-1)-infected cell types and the interplay of these infected cells in vivo should provide valuable information to elucidate the pathogenesis of HTLV-1-associated diseases in humans and in animal models. In this study, HTLV-1-infected cell types were identified in HTLV
- Stabilization from autoproteolysis and kinetic characterization of the human T-cell leukemia virus type 1 proteinase.
- J Biol Chem. 1999 Mar 5;274(10):6660-6. Unique Identifier : AIDSLINE MED/99156953
- Louis JM; Oroszlan S; Tozser J; Laboratory of Chemical Physics, NIDDK, National Institutes of; Health, Bethesda, Maryland 20892, USA. jmlouis@helix.nih.gov
- We have developed a system for expression and purification of wild-type human T-cell leukemia virus type 1 (HTLV-1) proteinase to attain sufficient quantities for structural, kinetic, and biophysical investigations. However, similar to the human immunodeficiency virus type 1 (HIV-1) proteinase, HTLV-1 proteinase also
- Interleukin-12 induces expression of interferon regulatory factor-1 via signal transducer and activator of transcription-4 in human T helper type 1 cells.
- J Biol Chem. 1999 Mar 5;274(10):6698-703. Unique Identifier : AIDSLINE MED/99156957
- Coccia EM; Passini N; Battistini A; Pini C; Sinigaglia F; Rogge L; Laboratory of Immunology, Istituto Superiore di Sanita, I-00161; Rome, Italy.
- IRF-1-deficient mice show a striking defect in the development of T helper 1 (Th1) cells. In the present report, we investigate the expression of IRF-1 during differentiation of human T helper cells. No significant differences of IRF-1 mRNA expression were found in established Th1 and Th2 cells; however, interleukin 1
- Depression predicts procedural but not episodic memory in HIV-1 infection.
- J Clin Exp Neuropsychol. 1998 Aug;20(4):529-35. Unique Identifier : AIDSLINE MED/99107074
- Kalechstein AD; Hinkin CH; van Gorp WG; Castellon SA; Satz P; Department of Psychiatry and Biobehavioral Sciences, University; of California Los Angeles Neuropsychiatric Institute and; Hospital, USA. adk@ucla.edu
- Forty-three homosexual/bisexual males with HIV-1 infection participated in a study that sought to determine: (1) whether increased levels of self-reported depressive symptomatology were associated with poorer performance on episodic or procedural memory tasks, (2) the relative strength of association between the affec
- Syphilis in an HIV infected patient misdiagnosed as leprosy.
- J Cutan Pathol. 1999 Jan;26(1):51-4. Unique Identifier : AIDSLINE MED/99140241
- Fonseca E; Garcia-Silva J; del Pozo J; Yebra MT; Cuevas J; Contreras F; Department of Dermatology, Hospital Juan Canalejo, La Coruna,; Spain. Fonseca@canalejo.cesga.es
- A 42-year-old man with uveitis and a widespread cutaneous eruption, histopathologically characterized by dermal granulomatous infiltrates with perineurial invasion, was incorrectly diagnosed and treated as having borderline leprosy. Further studies demonstrated secondary syphilis and human immunodeficiency virus (HIV)
- Epidemiology of HIV and AIDS in Bahrain.
- J Commun Dis. 1997 Dec;29(4):321-8. Unique Identifier : AIDSLINE MED/99185556
- al-Haddad MK; Baig BZ; Ebrahim RA; Psychiatric Hospital, Bahrain, Arabian Gulf.
- Between 1986 and 1996, 378 HIV cases were identified in Bahrain , of whom 51% were foreign nationals. Intravenous drug abuse was a major risk factor (38.8%) among Bahraini nationals, while transmission through sexual contact was more common (45.7%) among foreigners. Other well know
- The effect of commencing combination antiretroviral therapy soon after human immunodeficiency virus type 1 infection on viral replication and antiviral immune responses.
- J Infect Dis. 1999 Mar;179(3):527-37. Unique Identifier : AIDSLINE MED/99137787
- Markowitz M; Vesanen M; Tenner-Racz K; Cao Y; Binley JM; Talal A; Hurley A; Ji X; Chaudhry MR; Yaman M; Frankel S; Heath-Chiozzi M; Leonard JM; Moore JP; Racz P; Nixon DF; Ho DD; Aaron Diamond AIDS Research Center, Rockefeller University, New; York, NY 10016, USA. marty@adarc.org
- Twelve subjects were treated with zidovudine, lamivudine, and ritonavir within 90 days of onset of symptoms of acute infection to determine whether human immunodeficiency virus type 1 (HIV-1) infection could be eradicated from an infected host. In adh
- Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocyte activity in HIV-exposed seronegative persons.
- J Infect Dis. 1999 Mar;179(3):538-47. Unique Identifier : AIDSLINE MED/99137788
- Bernard NF; Yannakis CM; Lee JS; Tsoukas CM; Immunodeficiency Treatment Center, McGill University Hospital; Center, Montreal General Hospital, Montreal, Quebec, H3G 1A4,; Canada. mctl@musica.mcgill.ca
- Repeated exposure to human immunodeficiency virus (HIV) does not always result in seroconversion. Understanding the conditions that permit or protect against progressive infection with HIV is important for vaccine development. Nineteen subjects at risk for HIV infection were CCR-5 genotyped and screened for virus-spec
- Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: evidence for T cell immunity in the absence of inherited CCR5 coreceptor defects.
- J Infect Dis. 1999 Mar;179(3):548-57. Unique Identifier : AIDSLINE MED/99137789
- Goh WC; Markee J; Akridge RE; Meldorf M; Musey L; Karchmer T; Krone M; Collier A; Corey L; Emerman M; McElrath MJ; Division of Molecular Medicine, Fred Hutchinson Cancer Research; Center, Seattle, WA 98109-1024, USA. wgoh@fhcrc.org
- It has been hypothesized that protection against human immunodeficiency virus (HIV)-1 infection may result from either acquired host immunity, inheritance of a dysfunctional CCR5 HIV-1 coreceptor, or a low or attenuated virus inoculum. Thirty-seven HIV-1-uninfected persons engaging in repeated high-risk sexual activit
- Immunization with human immunodeficiency virus type 1 rgp120W61D in QS21/MPL adjuvant primes T cell proliferation and C-C chemokine production to multiple epitopes within variable and conserved domains of gp120W61D.
- J Infect Dis. 1999 Mar;179(3):558-66. Unique Identifier : AIDSLINE MED/99137790
- Jones GJ; von Hoegen P; Weber J; Rees AD; GU Medicine and Communicable Diseases, Imperial College School of; Medicine at St. Mary's, London, W2 1PG, United Kingdom.; gareth.jones@ic.ac.uk
- Human immunodeficiency virus type 1 (HIV-1) gp120W61D-specific T cell lines (TCL) were generated from an HIV-1-seronegative volunteer who received rgp120W61D in QS21/MPL adjuvant with emulsion. TCL were challenged with pools of consecutive, overlapping peptides spanning the gp120W61D sequence and then with the individ
- Efficacy of zidovudine and human immunodeficiency virus (HIV) hyperimmune immunoglobulin for reducing perinatal HIV transmission from HIV-infected women with advanced disease: results of Pediatric AIDS Clinical Trials Group protocol 185.
- J Infect Dis. 1999 Mar;179(3):567-75. Unique Identifier : AIDSLINE MED/99137791
- Stiehm ER; Lambert JS; Mofenson LM; Bethel J; Whitehouse J; Nugent R; Moye J Jr; Glenn Fowler M; Mathieson BJ; Reichelderfer P; Nemo GJ; Korelitz J; Meyer WA 3rd; Sapan CV; Jimenez E; Gandia J; Scott G; O'Sullivan MJ; Kovacs A; Stek A; Shearer WT; Hammill H; Department of Pediatrics, University of California at Los Angeles; Medical Center, Los Angeles, CA 90095-1752, USA.; estiehm@pediatrics.medsch.ucla.edu
- Pediatric AIDS Clinical Trials Group protocol 185 evaluated whether zidovudine combined with human immunodeficiency virus (HIV) hyperimmune immunoglobulin (HIVIG) infusions administered monthly during pregnancy and to the neonate at birth would significantly lower perinatal HIV transmission compared with treatment wit
- Virologic and immunologic response to nucleoside reverse-transcriptase inhibitor therapy among human immunodeficiency virus-infected infants and children.
- J Infect Dis. 1999 Mar;179(3):576-83. Unique Identifier : AIDSLINE MED/99137792
- Palumbo PE; Raskino C; Fiscus S; Pahwa S; Schutzbank T; Spector SA; Baker CJ; Englund JA; Department of Pediatrics, University of Medicine and Dentistry of; New Jersey, Newark, NJ 07103, USA. palumbo@umdnj.edu
- Plasma human immunodeficiency virus RNA and CD4 lymphocyte response to nucleoside reverse-transcriptase therapy were evaluated in a large, comparative pediatric trial. Both baseline values and changes in the two laboratory markers over time correlated well with clinical outcome and possessed independent predictive val
- Impaired phagocyte oxidative capacity in human immunodeficiency virus-infected children.
- J Infect Dis. 1999 Mar;179(3):584-9. Unique Identifier : AIDSLINE MED/99137793
- Hayani KC; Verral SC; Pitrak DL; Division of Pediatric Infectious Diseases, Department of; Pediatrics, University of Illinois College of Medicine at; Chicago, Chicago, IL 60612-7324, USA. U12017@UIC.edu
- Children infected with the human immunodeficiency virus (HIV) have T helper cell deficiency, but frequent bacterial infections suggest phagocyte dysfunction. Whole blood chemiluminescence (CL) assays were used to measure the respiratory burst capacity of phagocytes from HIV-infected children, perinatally HIV-exposed b
- Maternal virus load and perinatal human immunodeficiency virus type 1 subtype E transmission, Thailand. Bangkok Collaborative Perinatal HIV Transmission Study Group.
- J Infect Dis. 1999 Mar;179(3):590-9. Unique Identifier : AIDSLINE MED/99137794
- Shaffer N; Roongpisuthipong A; Siriwasin W; Chotpitayasunondh T; Chearskul S; Young NL; Parekh B; Mock PA; Bhadrakom C; Chinayon P; Kalish ML; Phillips SK; Granade TC; Subbarao S; Weniger BG; Mastro TD; Centers for Disease Control and Prevention, Atlanta, GA 30333,; USA. nas4@cdc.gov
- To determine the rate and risk factors for human immunodeficiency virus (HIV)-1 subtype E perinatal transmission, with focus on virus load, pregnant HIV-infected women and their formula-fed infants were followed prospectively in Bangkok. Of 281 infants with known outcome, 68 were infected (transmission rate, 24.2%; 95
- Coinfection of macaques with simian immunodeficiency virus and simian T cell leukemia virus type I: effects on virus burdens and disease progression.
- Unique Identifier : AIDSLINE MED/99137795
- Fultz PN; McGinn T; Davis IC; Romano JW; Li Y; Department of Microbiology, University of Alabama School of; Medicine, Birmingham, AL 35294, USA.
- To test the hypothesis that coinfection with human immunodeficiency virus (HIV) and human T cell leukemia/lymphoma virus types I or II (HTLV-I or -II) accelerates progression to AIDS, pig-tailed macaques were inoculated with the simian counterparts, SIV and STLV-I. During 2 years of follow-up of singly and dually infe
- Lactobacilli and vaginal host defense: activation of the human immunodeficiency virus type 1 long terminal repeat, cytokine production, and NF-kappaB.
- J Infect Dis. 1999 Mar;179(3):653-60. Unique Identifier : AIDSLINE MED/99137801
- Klebanoff SJ; Watts DH; Mehlin C; Headley CM; Department of Medicine, University of Washington, Seattle, WA; 98195-7185, USA. seym@u.washington.edu
- Lactobacilli, a component of the normal vaginal flora, can activate the human immunodeficiency virus (HIV)-1 long terminal repeat (LTR) in the Jurkat T lymphocyte and THP-1 macrophage cell lines. Activation of the LTR in Jurkat cells was strongly enhanced by vanadate and inhibited by catalase, implicating H2O2. In con
- Infrequent detection of TT virus infection in intravenous drug users, prostitutes, and homosexual men.
- J Infect Dis. 1999 Mar;179(3):686-9. Unique Identifier : AIDSLINE MED/99137806
- MacDonald DM; Scott GR; Clutterbuck D; Simmonds P; Department of Medical Microbiology, University of Edinburgh,; Edinburgh, EH8 9AG, United Kingdom.
- TT virus (TTV), a recently discovered DNA virus, has been implicated as a cause of non-A to non-C posttransfusion hepatitis. The frequency of TTV in persons considered at high risk for sexual and parenteral infection was investigated (52 prostitutes, 81 homosexual men, 65 intravenous drug users) to assess its mode of
- Expression of granzyme B during primary cytomegalovirus infection after renal transplantation.
- J Infect Dis. 1999 Mar;179(3):693-6. Unique Identifier : AIDSLINE MED/99137808
- Wever PC; Spaeny LH; van der Vliet HJ; Rentenaar RJ; Wolbink AM; Surachno J; Wertheim PM; Schellekens PT; Hack CE; ten Berge IJ; Department of Medical Microbiology, Academic Medical Center,; University of Amsterdam, Amsterdam, The Netherlands.
- CD8+ T cells employ granzyme B (GrB) to induce apoptosis in target cells. Increased expression of GrB has been put forward as a diagnostic marker in transplant rejection and viral infection. Three-color flow cytometric analysis revealed that peripheral blood CD8+ T lymphocytosis during primary
- Incidence of immune recovery vitritis in cytomegalovirus retinitis patients following institution of successful highly active antiretroviral therapy.
- J Infect Dis. 1999 Mar;179(3):697-700. Unique Identifier : AIDSLINE MED/99137809
- Karavellas MP; Plummer DJ; Macdonald JC; Torriani FJ; Shufelt CL; Azen SP; Freeman WR; Department of Ophthalmology, Shiley Eye Center, University of; California, San Diego, La Jolla, CA 92093-0946, USA.; mkaravellas@netscape.net
- This study was conducted to determine the likelihood of the development of a new ocular inflammatory syndrome (immune recovery vitritis, IRV), which causes vision loss in AIDS patients with cytomegalovirus ( CMV ) retinitis, wh
- Molluscum contagiosum virus: antibody responses in persons with clinical lesions and seroepidemiology in a representative Australian population.
- J Infect Dis. 1999 Mar;179(3):701-4. Unique Identifier : AIDSLINE MED/99137810
- Konya J; Thompson CH; Department of Infectious Diseases, Faculty of Medicine,; University of Sydney, Sydney, New South Wales 2006, Australia.
- An ELISA for molluscum contagiosum virus (MCV) was used to determine the antibody status of 35 adults with clinical infections and known human immunodeficiency virus (HIV) serology and of 357 persons (ages, 1 week-69 years) considered representative of the Australian population. MCV antibody was identified in 77% of p
- Codon 215 mutations in human immunodeficiency virus-infected pregnant women. Swiss Collaborative 'HIV and Pregnancy' Study.
- J Infect Dis. 1999 Mar;179(3):705-8. Unique Identifier : AIDSLINE MED/99137811
- Kully C; Yerly S; Erb P; Kind C; Krautheim A; Perrin L; Rudin C; Department of Pediatrics, University Children's Hospital, CH-4058; Basel, Switzerland. charlotte.kully@pupk.unibe.ch
- In 1994, the Pediatric AIDS Clinical Trials Group (PACTG) Protocol 076 demonstrated a two-thirds reduction of perinatal human immunodeficiency virus (HIV) type 1 transmission with zidovudine chemoprophylaxis. However, zidovudine alone does not fully suppress HIV replication, and chemoprophylaxis with zidovudine alone
- Antiviral activity of the human immunodeficiency virus type 1-specific nonnucleoside reverse transcriptase inhibitor HBY 097 alone and in combination with zidovudine in a phase II study. HBY 097/2001 Study Group.
- J Infect Dis. 1999 Mar;179(3):709-13. Unique Identifier : AIDSLINE MED/99137812
- Kleim JP; Winters M; Dunkler A; Suarez JR; Riess G; Winkler I; Balzarini J; Oette D; Merigan TC; Clinical Virology Unit, Glaxo Wellcome, Stevenage, Herts SG1 2NY,; United Kingdom. jpk49970@GlaxoWellcome.co.uk
- The safety and antiviral activity of the second-generation nonnucleoside inhibitor HBY 097 was investigated in asymptomatic or mildly symptomatic human immunodeficiency virus (HIV)-1-infected patients in a randomized, double-blinded, dose-escalation study. Mean maximum virus load decreases ranged from -1.31 log10 copi
- LTB4 and LTC4 are absent in the cerebrospinal fluid of human immunodeficiency virus type 1-seropositive persons with toxoplasmic encephalitis: evidence for inhibition of 5-lipoxygenase by Toxoplasma gondii.
- J Infect Dis. 1999 Mar;179(3):714-6. Unique Identifier : AIDSLINE MED/99137813
- Mayatepek E; Flock B; Zelezny R; Kreutzer K; von Giesen HJ; Department of General Pediatrics, University Children's Hospital,; 69120 Heidelberg, Germany. ertan_mayatepek@ukl.uni-heidelberg.de
- Previous studies on macrophages have shown that Toxoplasma gondii alters the metabolism of arachidonic acid with subsequent inability to generate leukotrienes (LT)s. LTB4 and LTC4 were analyzed in cerebrospinal fluid of 3 groups of human immunodeficiency virus (HIV) type 1-seropositive patients: with toxoplasmic encep
- Combination antiretroviral therapy and recent declines in AIDS incidence and mortality.
- J Infect Dis. 1999 Mar;179(3):717-20. Unique Identifier : AIDSLINE MED/99137814
- Vittinghoff E; Scheer S; O'Malley P; Colfax G; Holmberg SD; Buchbinder SP; Department of Epidemiology and Biostatistics, University of; California, San Francisco, CA 94105, USA. eric@retriever.ucsf.edu
- The reasons for recent declines in AIDS incidence and mortality may include advances in treatment, but these may be confounded by earlier declines in the incidence of human immunodeficiency virus (HIV) infection. To determine whether the declines in AIDS and mortality may, in part, stem from wider use of combination a
- Chemokine-induced phosphorylation of CC chemokine receptor 5 (CCR5).
- J Leukoc Biol. 1999 Mar;65(3):281-5. Unique Identifier : AIDSLINE MED/99178613
- Olbrich H; Proudfoot AE; Oppermann M; Department of Immunology, University of Gottingen, Germany.
- The CC-chemokine receptor 5 (CCR5) mediates activation of T lymphocytes and macrophages by chemokines and is a major co-receptor for macrophage-tropic HIV-1 strains. Recently, it was shown that the natural CCR5 ligands RANTES, macrophage inflammatory protein-1alpha (MIP-1alpha), MIP-1beta, and amino-terminal modificat
- Value of combined approach with thallium-201 single-photon emission computed tomography and Epstein-Barr virus DNA polymerase chain reaction in CSF for the diagnosis of AIDS-related primary CNS lymphoma.
- J Clin Oncol. 1999 Feb;17(2):554-60. Unique Identifier : AIDSLINE MED/99178684
- Antinori A; De Rossi G; Ammassari A; Cingolani A; Murri R; Di Giuda D; De Luca A; Pierconti F; Tartaglione T; Scerrati M; Larocca LM; Ortona L; Department of Infectious Diseases, Catholic University, Rome,; Italy. andranto@tin.it
- PURPOSE: To determine the diagnostic capability of thallium-201 (201Tl) single-photon emission computed tomography (SPECT) combined with Epstein-Barr virus DNA (EBV-DNA) in CSF for the diagnosis of AIDS-related primary CNS lymphoma (PCNSL). PATIENTS AND METHODS: All human immunodef
- Intracranial leiomyosarcoma: a neuro-oncological consequence of acquired immunodeficiency syndrome.
- J Neurooncol. 1998 Nov;40(2):179-83. Unique Identifier : AIDSLINE MED/99107118
- Litofsky NS; Pihan G; Corvi F; Smith TW; Division of Neurosurgery, University of Massachusetts Medical; School, Worcester 01655, USA. scott.litofsky@banyan.ummed.edu
- Leiomyosarcoma has recently been identified as an AIDS-related tumor, usually occurring in children in the chest or abdomen. We describe a case of intracranial leiomyosarcoma in an adult with AIDS. An enhancing mass adjacent to the right occipital cortical surface was diagnosed during a work-up for left arm weakness.
- Individual, family, and relationship predictors of young women's sexual risk perceptions.
- Unique Identifier : AIDSLINE MED/99122253
- Hutchinson MK
- OBJECTIVE: To identify the individual, dyad, and family variables that influence young women s perceptions of risk for sexually transmitted diseases (STDs), including human immunodeficiency virus (HIV). DESIGN: Cross-sectional telephone survey using forced-choice questioning. Data were analyzed using first-order corre
- Analysis of peripheral blood leukocytes in patients with cyclosporine A-induced gingival hyperplasia.
- J Periodontol. 1998 Dec;69(12):1435-9. Unique Identifier : AIDSLINE MED/99123965
- Cebeci I; Kantarci A; Gurel N; Adin S; Tuncer O; Carin M; Badur S; Firatli E; Department of Periodontology, School of Dentistry, University of; Istanbul, Turkey.
- BACKGROUND: Gingival overgrowth is one of the major adverse effects of the immunosuppressive drug cyclosporine A (CsA). Although several studies have attempted to determine the immunological mechanisms of gingival hyperplasia (GO) due to CsA therapy, the pathogenesis remains unclear. In this study, the distribution of
- Thematic instrument for measuring death anxiety in children (TIMDAC).
- J Pediatr Nurs. 1999 Feb;14(1):28-37. Unique Identifier : AIDSLINE MED/99162733
- Ireland M; Malgady RG; College of Nursing, Rutgers, State University of New Jersey,; Newark 07102, USA.
- Few instruments measure death anxiety in children, especially, children of color. This article describes the development and psychometric properties of the projective instrument, the Thematic Instrument for Measuring Death Anxiety in Children (TIMDAC), a culturally sensitive tool that was developed to compare levels o
- Development of a single-shot subunit vaccine for HIV-1. 5. programmable in vivo autoboost and long lasting neutralizing response.
- J Pharm Sci. 1998 Dec;87(12):1489-95. Unique Identifier : AIDSLINE MED/99140449
- Cleland JL; Lim A; Daugherty A; Barron L; Desjardin N; Duenas ET; Eastman DJ; Vennari JC; Wrin T; Berman P; Murthy KK; Powell MF; Department of Pharmaceutical Research and Development, Genentech,; Inc., South San Francisco, California 94080, USA.; cleland@gene.com
- The subunit vaccine for HIV-1, recombinant glycoprotein 120 (rgp120), was used as a model antigen to evaluate the potential for a pulsatile single immunization vaccine formulation consisting of poly(lactic-co-glycolic) acid (PLGA) microspheres. We designed rgp120 PLGA microsphere formulations that provide a pulse of r
- N,N'-Diacetyl-L-cystine-the disulfide dimer of N-acetylcysteine-is a potent modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents.
- J Pharmacol Exp Ther. 1999 Mar;288(3):1174-84. Unique Identifier : AIDSLINE MED/99152177
- Sarnstrand B; Jansson AH; Matuseviciene G; Scheynius A; Pierrou S; Bergstrand H; Department of Pharmacology, Astra Draco AB, Lund, Sweden.
- Oral N-acetyl-L-cysteine (NAC) is used clinically for treatment of chronic obstructive pulmonary disease. NAC is easily oxidized to its disulfide. We show here that N,N -diacetyl-L-cystine (DiNAC) is a potent modulator of contact sensitivity (CS)/delayed type hypersensitivity (DTH) reactions in rodents. Oral treatment
- Nuclear medicine imaging in infection and inflammation.
- J R Coll Physicians Lond. 1998 Nov-Dec;32(6):512-9. Unique Identifier : AIDSLINE MED/99097979
- Peters AM; Department of Imaging, Hammersmith Hospital, London.
- Tuberculosis in African born adults [letter]
- J R Coll Physicians Lond. 1998 Nov-Dec;32(6):589-90. Unique Identifier : AIDSLINE MED/99097995
- Coker R
- Recombination during reverse transcription: an evaluation of the role of the nucleocapsid protein.
- J Mol Biol. 1999 Feb 12;286(1):15-31. Unique Identifier : AIDSLINE MED/99134385
- Negroni M; Buc H; Unite de Physicochimie des Macromolecules Biologiques, (URA1773; du CNRS), Paris Cedex 15, 75724, France. matteo@pasteur.fr
- The human immuno deficiency virus type 1 nucleocapsid protein 7 (HIV-1 NCp7) is a major component of the reverse transcription complex. Its effect on reverse transcription and homologous recombination has been studied in vitro under strictly identical experimental conditions. For high enzyme concentrations, NCp7 did n
- Model for lentivirus capsid core assembly based on crystal dimers of EIAV p26.
- J Mol Biol. 1999 Feb 12;286(1):83-93. Unique Identifier : AIDSLINE PDB/2EIA
- Jin Z; Jin L; Peterson DL; Lawson CL; Biology Department, Brookhaven National Laboratory, Upton, NY,; 11973, USA.
- Two crystal forms of recombinant p26 capsid protein (CA) from the equine infectious anemia virus (EIAV) have in common an antiparallel four-helix bundle dimer interface between N-terminal domains (NTDs). The dimer interface provides a lenient scaffold to accommodate the wide sequence variation in these helices within
- Expression of vascular endothelial growth factor receptor-3 and podoplanin suggests a lymphatic endothelial cell origin of Kaposi's sarcoma tumor cells.
- Lab Invest. 1999 Feb;79(2):243-51. Unique Identifier : AIDSLINE MED/99165581
- Weninger W; Partanen TA; Breiteneder-Geleff S; Mayer C; Kowalski H; Mildner M; Pammer J; Sturzl M; Kerjaschki D; Alitalo K; Tschachler E; Division of Immunology, Allergy, and Infectious Diseases,; University of Vienna, Austria.
- Despite intensive research over the past decade, the exact lineage relationship of Kaposi s sarcoma (KS) tumor cells has not yet been settled. In the present study, we investigated the expression of two markers for lymphatic endothelial cells (EC), ie, vascular endothelial growth factor receptor-3 (VEGFR-3) and podopl
- Meningioma in four patients with human immunodeficiency virus infection.
- Mayo Clin Proc. 1999 Mar;74(3):253-7. Unique Identifier : AIDSLINE MED/99189864
- Khurshid A; Joseph JT; Rachlin J; Cooley TP; Kleefield J; Dezube BJ; Division of Hematology/Oncology, Beth Israel Deaconess Medical; Center, Boston, MA 02215, USA.
- We describe four patients infected with the human immunodeficiency virus (HIV) who had development of meningiomas. In contrast to those in the general population who have meningiomas, all our patients were young men; the mean age was 40 years (range, 32 to 50). Their risk behavior for HIV was homosexuality (three pati
- [Promising experiments with DNA vaccine against HIV. A complete eradication of the virus is a formidable task]
- Lakartidningen. 1999 Feb 17;96(7):722-5. Unique Identifier : AIDSLINE MED/99187738
- Wahren B; Smittskyddsinstitutet, Karolinska institutet, Stockholm.; Britta.Wahren@smi.ki.se
- The past few years have witnessed encouraging progress in experimental HIV vaccination. Several new vaccine candidates have been shown to elicit immune response and provide protection in animals, and the first immunotherapy trials in humans have been reported. Difficulties remain to be overcome, however. No consensus
- Rifapentine--a long-acting rifamycin for tuberculosis.
- Med Lett Drugs Ther. 1999 Feb 26;41(1047):21-2. Unique Identifier : AIDSLINE MED/99175890
- Pilot study with clozapine in patients with HIV-associated psychosis and drug-induced parkinsonism.
- Mov Disord. 1999 Jan;14(1):128-31. Unique Identifier : AIDSLINE MED/99114914
- Lera G; Zirulnik J; Neurology Unit, Juan A. Fernandez Hospital, Buenos Aires,; Argentina.
- Clozapine (CZP) is an atypical antipsychotic drug that does not appear to block striatal dopamine receptors. In six patients who met the criteria of HIV-associated psychosis and who had previously developed moderate parkinsonism as a result of the use of typical neuroleptic agents, CZP was added in an open, rising dos
- Elective cesarean delivery to reduce the transmission of HIV [editorial; comment]
- N Engl J Med. 1999 Apr 1;340(13):1032-3. Unique Identifier : AIDSLINE MED/99182219
- Riley LE; Greene MF
- Short courses of zidovudine and perinatal transmission of HIV [letter]
- N Engl J Med. 1999 Apr 1;340(13):1040-1; discussion 1042-3. Unique Identifier : AIDSLINE MED/99182223
- Fiscus SA; Schoenbach VJ; Wilfert C
- Short courses of zidovudine and perinatal transmission of HIV [letter]
- N Engl J Med. 1999 Apr 1;340(13):1041; discussion 1042-3. Unique Identifier : AIDSLINE MED/99182224
- Thomas P; Bornschlegel K
- Short courses of zidovudine and perinatal transmission of HIV [letter]
- N Engl J Med. 1999 Apr 1;340(13):1041-2; discussion 1042-3. Unique Identifier : AIDSLINE MED/99182225
- Feiterna-Sperling C; Maier RF; Grosch-Worner I
- Short courses of zidovudine and perinatal transmission of HIV [letter]
- N Engl J Med. 1999 Apr 1;340(13):1042-3. Unique Identifier : AIDSLINE MED/99182226
- Shaffer N; Bulterys M; Simonds RJ
- Human herpesvirus 8 and renal transplantation [letter]
- N Engl J Med. 1999 Apr 1;340(13):1045; discussion 1046. Unique Identifier : AIDSLINE MED/99182229
- Frances C; Mouquet C; Calvez V
- Human herpesvirus 8 and renal transplantation [letter]
- N Engl J Med. 1999 Apr 1;340(13):1045-6. Unique Identifier : AIDSLINE MED/99182230
- Rabkin CS; Shepherd FA; Wade JA
- The mode of delivery and the risk of vertical transmission of human immunodeficiency virus type 1--a meta-analysis of 15 prospective cohort studies. The International Perinatal HIV Group [see comments]
- N Engl J Med. 1999 Apr 1;340(13):977-87. Unique Identifier : AIDSLINE MED/99182213
- BACKGROUND: To evaluate the relation between elective cesarean section and vertical transmission of human immunodeficiency virus type 1 (HIV-1), we performed a meta-analysis using data on individual patients from 15 prospective cohort studies. METHODS: North American and European studies of at least 100 mother-child p
- [Vertical HIV-I-transmission. I. Risk and prevention in pregnancy]
- Ned Tijdschr Geneeskd. 1998 Dec 12;142(50):2720-4. Unique Identifier : AIDSLINE MED/99164629
- Orendi JM; Boer K; van Loon AM; Borleffs JC; van Oppen AC; Boucher CA; Eijkman-Winkler Laboratorium voor Microbiologie, Infectieziekten; en Ontsteking, afd. Virologie, Academisch Ziekenhuis Utrecht.
- Without anti-HIV treatment, mother to child HIV-I transmission occurs in 15-30% of HIV positive pregnancies. Transmission occurs mostly in the last trimester or at birth. The maternal virus load in the last trimester and around birth is strongly related to the risk of HIV transmission to the child. This risk can be re
- [Vertical HIV-I-transmission. II. HIV-diagnosis in a child]
- Ned Tijdschr Geneeskd. 1998 Dec 12;142(50):2724-8. Unique Identifier : AIDSLINE MED/99164630
- Orendi JM; Geelen SP; de Graeff-Meeder ER; van Loon AM; Schuurman R; Boucher CA; Eijkman-Winkler Laboratorium voor Microbiologie, Infectieziekten; en Ontsteking, afd. Virologie, Academisch Ziekenhuis Utrecht.
- In newborn children from HIV-infected women early establishment of HIV infection is of importance for optimal therapy of HIV-infected children and avoidance of unnecessary medication in uninfected children. A more than 95% reliable diagnosis of HIV infection can now be obtained at the age of four weeks by polymerase c
- Expression of brain-derived neurotrophic factor protein in activated microglia of human immunodeficiency virus type 1 encephalitis.
- Neuropathol Appl Neurobiol. 1998 Dec;24(6):453-60. Unique Identifier : AIDSLINE MED/99105102
- Soontornniyomkij V; Wang G; Pittman CA; Wiley CA; Achim CL; Department of Pathology (Neuropathology), University of; Pittsburgh School of Medicine, Pennsylvania, USA.
- The role of neurotrophic factors and their therapeutic potential have been investigated in various neurodegenerative disorders. In neurodegeneration associated with human immunodeficiency virus (HIV) infection, neuronal function and survival may be affected by abnormal neurotrophic regulation involving HIV-infected mi
- A murine model of HIV encephalitis: xenotransplantation of HIV-infected human neuroglia into SCID mouse brain.
- Neuropathol Appl Neurobiol. 1998 Dec;24(6):461-7. Unique Identifier : AIDSLINE MED/99105103
- Sanders VJ; Mehta AP; White MG; Achim CL; Department of Pathology, University of Pittsburgh School of; Medicine, PA 15213, USA.
- The degree of neuronal damage in HIV encephalitis (HIVE) and the mechanisms leading to it are not known. Post-mortem human studies provide limited information concerning pathogenesis, and there are few animal models of HIVE. We have developed a murine model of HIVE based on HIV-infected human brain tissues grafted wit
- Changes in neuron size in cynomolgus macaques infected with various immunodeficiency viruses and poliovirus.
- Neuropathol Appl Neurobiol. 1998 Dec;24(6):468-75. Unique Identifier : AIDSLINE MED/99105104
- Montgomery MM; Wood A; Stott EJ; Sharp C; Luthert PJ; Department of Pathology, University College London, UK.
- Human immunodeficiency virus (HIV) infection leads to clinically significant neuronal pathology, but the underlying mechanism remains unclear. Infection of rhesus macaques with the simian immunodeficiency virus SIVmac251 has been shown to cause atrophy of hippocampal pyramidal cells. The aim of the current investigati
- Interleukin-6 production by human monocytes treated with granulocyte-macrophage colony-stimulating factor in the presence of lipopolysaccharide of oral microorganisms.
- Oral Microbiol Immunol. 1998 Jun;13(3):173-80. Unique Identifier : AIDSLINE MED/99193492
- Baqui AA; Meiller TF; Chon JJ; Turng BF; Falkler WA Jr; Department of Oral Medicine, Dental School, University of; Maryland, Baltimore, USA.
- This study focused on the effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) and lipopolysaccharide of the putative periodontal pathogens Porphyromonas gingivalis or Fusobacterium nucleatum on IL-6 production by THP-1 cells (a human monocytic cell line). Resting THP-1 cells were alternatively treated
- Characterization of lymphocyte subpopulations in periapical lesions by flow cytometry.
- Oral Microbiol Immunol. 1998 Aug;13(4):253-8. Unique Identifier : AIDSLINE MED/99193501
- Sol MA; Tkaczuk J; Voigt JJ; Durand M; Sixou M; Maurette A; Thomsen M; Institut National de la Sante et de la Recherche Medicale, Unit; 466, Toulouse, France.
- The mechanisms by which the bacterial root-canal infection leads to periapical bone destruction (cysts or granulomas) are not yet well understood. Previous works have shown elements of an active immune response in the lesions. In the present study, flow cytometry was used to improve the characterization of immune cell
- Distribution of interleukin-2 receptor alpha-chain and cells expressing major histocompatibility complex class II antigen in chronic human periapical lesions.
- Oral Microbiol Immunol. 1998 Aug;13(4):259-62. Unique Identifier : AIDSLINE MED/99193502
- Marton IJ; Dezso B; Radics T; Kiss C; Department of Restorative Dentistry, University Medical School of; Debrecen, Hungary.
- In situ distribution of CD2+ T-lymphocytes, CD4+ and CD8+ T-cell subsets, CD14+ macrophages, interleukin-2 receptor alpha-chain (IL-2R alpha) and class II major histocompatibility complex antigen (major histocompatibility complex class II, HLA-DR) expressing cells were determined in 14 chronic human periapical granulo
- Discriminating against people with HIV.
- Nurs Times. 1999 Feb 10-16;95(6):21. Unique Identifier : AIDSLINE MED/99195323
- Mayho P
- Expression of endogenous retrovirus ERV-3 induces differentiation in BeWo, a choriocarcinoma model of human placental trophoblast.
- Placenta. 1999 Jan;20(1):109-18. Unique Identifier : AIDSLINE MED/99133651
- Lin L; Xu B; Rote NS; Department of Microbiology and Immunology, Wright State; University School of Medicine, Dayton, Ohio 45435, USA.
- Differentiation-related expression of endogenous retrovirus ERV-3 env in the normal human placental syncytiotrophoblast suggests a role in placental development. The choriocarcinoma cell line BeWo, a model of trophoblast differentiation, is maintained in an undifferentiated state and undergoes differentiation upon the
- Pain and depression in HIV illness.
- Psychosomatics. 1998 Nov-Dec;39(6):528-35. Unique Identifier : AIDSLINE MED/99037388
- Evans S; Ferrando S; Sewell M; Goggin K; Fishman B; Rabkin J; Department of Psychiatry, Cornell University Medical College, New; York, NY, USA. SUSAN_EVANS@yahoo.com
- The purpose of this study was to examine the relationship among pain and depression, hopelessness, and quality of life in human immunodeficiency virus (HIV)-infected gay men, taking into account the role of HIV symptoms. One hundred sixty-one HIV+ gay men were assessed, with 40 men endorsing HIV-related pain. The HIV+
- New-onset amnestic syndrome in AIDS patients with past history of alcohol abuse.
- Psychosomatics. 1998 Nov-Dec;39(6):551-3. Unique Identifier : AIDSLINE MED/99037393
- Viswanathan R; Pilman M; Hasaj M; State University of New York Health Science Center at Brooklyn; 11203, USA.
- [Check-up studies at an internal medicine polyclinic: reasons, diagnostic tests, results and therapeutic consequences]
- Unique Identifier : AIDSLINE MED/99106259
- Osterwalder P; Steurer J; Departement fur Innere Medizin, Medizinische Poliklinik,; Zurich.
- Data of an investigation on initial motives for and outcome of so-called diagnostic check-ups are presented. Over a period of about one year a total of 82 persons applying for such a check-up have been investigated. Concrete reasons for this step were not given initially, however, elucidated in 87% of cases after spec
- Linear differentiation of cytotoxic effectors into memory T lymphocytes.
- Science. 1999 Mar 12;283(5408):1745-8. Unique Identifier : AIDSLINE MED/99174090
- Opferman JT; Ober BT; Ashton-Rickardt PG; Committee on Immunology, Department of Pathology, Committee on; Developmental Biology, The University of Chicago, Gwen Knapp; Center for Lupus and Immunology Research, Chicago, IL 60637, USA.
- A central question in immunology is the origin of long-lived T cell memory that confers protection against recurrent infection. The differentiation of naive T cell receptor transgenic CD8+ cells into effector cytotoxic T lymphocytes (CTLs) and memory CD8+ cells was studied. Memory CD8+ cells that were generated after
- HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage.
- Science. 1999 Mar 12;283(5408):1748-52. Unique Identifier : AIDSLINE MED/99174091
- Carrington M; Nelson GW; Martin MP; Kissner T; Vlahov D; Goedert JJ; Kaslow R; Buchbinder S; Hoots K; O'Brien SJ; Intramural Research Support Program, Science Applications; International Corporation Frederick, National Cancer Institute; (NCI), Frederick, MD 21702-1201, USA.
- A selective advantage against infectious disease associated with increased heterozygosity at the human major histocompatibility complex [human leukocyte antigen (HLA) class I and class II] is believed to play a major role in maintaining the extraordinary allelic diversity of these genes. Maximum HLA heterozygosity of
- Combined effects of HIV-infection status and psychosocial vulnerability on mental health in homosexual men.
- Soc Psychiatry Psychiatr Epidemiol. 1999 Jan;34(1):4-11. Unique Identifier : AIDSLINE MED/99172770
- Dickey WC; Dew MA; Becker JT; Kingsley L; Department of Epidemiology and Psychiatry, University of; Pittsburgh, Graduate School of Public Health, School of Medicine,; Pennsylvania, USA. dickeywc@msx.upmc.edu
- The present study examines psychiatric symptomatology and syndromal depression among 174 HIV+ and 760 HIV- homosexual men enrolled in the Pittsburgh site of the Multicenter AIDS Cohort Study (MACS). A central study goal was to determine whether men s psychosocial status in the areas of demographics, social supports, a
- Abacavir for treatment of HIV infection [news]
- Am Fam Physician. 1999 Mar 1;59(5):1329. Unique Identifier : AIDSLINE MED/99186744
- Endoscopic approach to HIV-associated diarrhea: how far is far enough? [editorial; comment]
- Am J Gastroenterol. 1999 Mar;94(3):556-9. Unique Identifier : AIDSLINE MED/99184435
- Bini EJ
- A prospective study of endoscopy in HIV-associated diarrhea [see comments]
- Am J Gastroenterol. 1999 Mar;94(3):596-602. Unique Identifier : AIDSLINE MED/99184441
- Kearney DJ; Steuerwald M; Koch J; Cello JP; University of California-San Francisco, USA.
- OBJECTIVE: Diarrhea commonly occurs in persons with human immunodeficiency virus (HIV) infection. The optimal use of endoscopic procedures remains poorly studied for patients with HIV-related diarrhea. The purpose of this study is to compare the diagnostic yield of a complete endoscopic work-up including an esophagoga
- Efficacy of lamivudine in patients with hepatitis B virus precore mutant infection before and after liver transplantation.
- Am J Gastroenterol. 1999 Mar;94(3):663-7. Unique Identifier : AIDSLINE MED/99184452
- Ben-Ari Z; Zemel R; Kazetsker A; Fraser G; Tur-Kaspa R; Liver Institute, Department of Medicine D, Felsenstein Medical; Research Center, Petah Tiqva, Israel.
- OBJECTIVE: Hepatitis B virus (HBV) precore mutant infection is associated with a more severe liver disease and a poorer response to interferon. We evaluated the efficacy and tolerance of lamivudine to induce complete and sustained suppression of viral replication in seven patients infected with HBV precore mutant (HBe
- Prevalence and predictors of severe acute pancreatitis in patients with acquired immune deficiency syndrome (AIDS).
- Am J Gastroenterol. 1999 Mar;94(3):784-9. Unique Identifier : AIDSLINE MED/99184470
- Manocha AP; Sossenheimer M; Martin SP; Sherman KE; Venkatesan T; Whitcomb DC; Ulrich CD 2nd; Department of Medicine, University of Cincinnati Medical Center,; Ohio, USA.
- OBJECTIVE: Recent case control data suggested that a severe course of acute pancreatitis in HIV+ patients was 1) common (50% of cases), 2) poorly predicted by Ranson s criteria (sensitivity 41%), and 3) accurately predicted by a diagnosis of AIDS (positive predictive value 67%). However, the definition of severity inc
- HIV-1 incidence among opiate users in northern Thailand.
- Am J Epidemiol. 1999 Mar 15;149(6):558-64. Unique Identifier : AIDSLINE MED/99181736
- Celentano DD; Hodge MJ; Razak MH; Beyrer C; Kawichai S; Cegielski JP; Nelson KE; Jittiwutikarn J; Department of Epidemiology, The Johns Hopkins University School; of Hygiene and Public Health, Baltimore, MD 21205, USA.
- The incidence of human immunodeficiency virus type 1 (HIV-1) infection among opiate users was determined in a retrospective cohort of 436 patients with multiple admissions to the only inpatient drug treatment program in northern Thailand between October 1993 and September 1995. D
- Production of interferon-gamma by lung lymphocytes in HIV-infected individuals.
- Am J Physiol. 1999 Feb;276(2 Pt 1):L256-62. Unique Identifier : AIDSLINE MED/99137638
- Twigg HL 3rd; Spain BA; Soliman DM; Knox K; Sidner RA; Schnizlein-Bick C; Wilkes DS; Iwamoto GK; Divisions of Pulmonary/Critical Care Medicine and Infectious; Diseases, Department of Medicine, Indiana University Medical; Center, Indianapolis, Indiana 46202, USA.
- A CD8(+) lymphocytic alveolitis occurs in up to 60% of asymptomatic human immunodeficiency virus (HIV)-infected individuals. Early in HIV infection, lymphocytes consist predominantly of cytotoxic T lymphocytes directed against HIV-infected targets. As HIV disease progresses, they are replaced by CD8(+)CD57(+) suppress
- Community-level interventions are needed to prevent new HIV infections [editorial; comment]
- Am J Public Health. 1999 Mar;89(3):299-301. Unique Identifier : AIDSLINE MED/99175772
- Kelly JA
- Community-level HIV intervention in 5 cities: final outcome data from the CDC AIDS Community Demonstration Projects [see comments]
- Unique Identifier : AIDSLINE MED/99175778
- OBJECTIVES: This study evaluated a theory-based community-level intervention to promote progress toward consistent condom and bleach use among selected populations at increased risk for HIV infection in 5 US cities. METHODS: Role-model stories were distributed, along with condoms and bleach, by community members who e
- The human immunodeficiency virus type I Tat protein potentiates ethanol-induced neutrophil functional impairment in transgenic mice.
- Alcohol Clin Exp Res. 1998 Dec;22(9):2043-9. Unique Identifier : AIDSLINE MED/99098618
- Prakash O; Zhang P; Xie M; Ali M; Zhou P; Coleman R; Stoltz DA; Bagby GJ; Shellito JE; Nelson S; Laboratory of Molecular Oncology, Alton Ochsner Medical; Foundation, New Orleans, Louisiana, USA.
- Neutropenia and impairment of neutrophil function are commonly observed in patients with human immunodeficiency virus (HIV) infections. The HIV regulatory protein Tat is known to exert immunosuppressive effects. Alcohol is known also to be an immunosuppressive factor, and as alcohol abuse is common among HIV infected
- Relations among CD4 lymphocyte count nadir, antiretroviral therapy, and HIV-1 disease progression: results from the EuroSIDA study.
- Ann Intern Med. 1999 Apr 6;130(7):570-7. Unique Identifier : AIDSLINE MED/99188830
- Miller V; Mocroft A; Reiss P; Katlama C; Papadopoulos AI; Katzenstein T; van Lunzen J; Antunes F; Phillips AN; Lundgren JD; J.W. Goethe-Universitat, Zentrum der Inneren Medizin, Frankfurt,; Germany. miller@em.uni-frankfurt.de
- BACKGROUND: The effect of previous CD4 cell count nadir on clinical progression in patients with increases in CD4 cell counts has not been investigated. OBJECTIVE: To assess risk for progression of HIV disease in patients with CD4 counts of at least 200 cells/mm3 (stratified by the lowest previous CD4 count) and compa
- Epstein-Barr virus in monitoring the response to therapy of acquired immunodeficiency syndrome-related primary central nervous system lymphoma.
- Ann Neurol. 1999 Feb;45(2):259-61. Unique Identifier : AIDSLINE MED/99142737
- Antinori A; Cingolani A; De Luca A; Gaidano G; Ammassari A; Larocca LM; Ortona L; Department of Infectious Diseases, Catholic University, Rome,; Italy.
- To evaluate the value of Epstein-Barr virus DNA (EBV-DNA) assay in cerebrospinal fluid (CSF) for monitoring the response to treatment in acquired immunodeficiency syndrome-related primary central nervous system lymphoma (AIDS-PCNSL), 9 human immunodeficiency virus-infected patients with biopsy-proven AIDS-PCNSL who un
- Cerebral tumor-like American trypanosomiasis in acquired immunodeficiency syndrome.
- Ann Neurol. 1999 Mar;45(3):403-6. Unique Identifier : AIDSLINE MED/99170275
- Pagano MA; Segura MJ; Di Lorenzo GA; Garau ML; Molina HA; Cahn P; Perez H; Vitolo F; Grondona A; Piedimonte FC; Giannaula R; Ramia R; Miranda MA; Sierra H; Sica RE; Department of Neurology, Fernandez Hospital, Buenos Aires,; Argentina.
- Cerebral tumor-like American trypanosomiasis (CTLAT) is an uncommon complication of Chagas disease, observed only in immunosuppressed patients. We assessed 10 human immunodeficiency virus-positive patients with Chagas disease who presented with CTLAT. All patients had neurological involvement and 6 developed intracr
- Social, community, and preventive interventions.
- Unique Identifier : AIDSLINE MED/99174252
- Reppucci ND; Woolard JL; Fried CS
- Psychology can and should be at the forefront of participation in social, community, and preventive interventions. This chapter focuses on selective topics under two general areas: violence as a public health problem and health promotion/competence promotion across the life span. Under violence prevention, discussion
- Identification of a novel bovine serum protein which is involved in human T-cell leukemia virus type I (HTLV-I)-induced syncytium formation.
- Arch Virol. 1999;144(1):1-18. Unique Identifier : AIDSLINE MED/99175801
- Okuma K; Nakamura M; Nakano S; Tanaka Y; Niho Y; First Department of Internal Medicine, Faculty of Medicine,; Kyushu University, Fukuoka, Japan.
- By immunizing rats with cocultured HTLV-I-positive ILT8M2 and HTLV-I-negative MOLT-4-cells, we isolated a monoclonal antibody (mAb), designated as mAb R21, which enhances the syncytium formation induced by coculturing ILT8M2 cells with MOLT-4 cells. The antigen recognized by mAb R21 was found on the surface of all T-c
- Cloning of a long HIV-1 readthrough transcript and detection of an increased level of early growth response protein-1 (Egr-1) mRNA in chronically infected U937 cells.
- Arch Virol. 1999;144(1):19-28. Unique Identifier : AIDSLINE GENBANK/Y12839
- Dron M; Hameau L; Benboudjema L; Guymarho J; Cajean-Feroldi C; Rizza P; Godard C; Jasmin C; Tovey MG; Lang MC; Laboratory of Viral Oncology, C.N.R.S., Villejuif, France.
- To identify the pathways involved in HIV-1 modification of cellular gene expression, chronically infected U937 cells were screened by mRNA differential display. A chimeric transcript consisting of the 3 end of the LTR of a HIV-1 provirus, followed by 3.7 kb of cellular RNA was identified suggesting that long readthro
- Active HIV-1 redistribution and replication in the brain with HIV encephalitis.
- Arch Virol. 1999;144(1):29-43. Unique Identifier : AIDSLINE MED/99175803
- Gatanaga H; Oka S; Ida S; Wakabayashi T; Shioda T; Iwamoto A; Department of Infectious Diseases, Institute of Medical Science,; University of Tokyo, Japan.
- The central nervous system (CNS) is of particular importance in human immunodeficiency virus type 1 (HIV-1) infection. First, the CNS may be difficult to access for anti-retroviral treatment and may become a sanctuary for residual viruses. Second, HIV-1 infection may lead to AIDS demen
- Insertion of sequences into the 3' untranslated region of a replication-competent spleen necrosis virus vector disrupts env gene expression.
- Arch Virol. 1999;144(1):73-87. Unique Identifier : AIDSLINE MED/99175806
- Yin PD; Hu WS; Department of Microbiology and Immunology, West Virginia; University, Morgantown, USA.
- The genomes of all replication-competent retroviruses contain cis-acting elements that regulate gene expression. However, the identities of many of these elements remain to be characterized. Inserting sequences into the 3 untranslated region of a replication-competent spleen necrosis virus (SNV) vector disrupted its
- Thimet oligopeptidase (EC 3.4.24.15), a novel protein on the route of MHC class I antigen presentation.
- Biochem Biophys Res Commun. 1999 Feb 24;255(3):591-5. Unique Identifier : AIDSLINE MED/99160397
- Silva CL; Portaro FC; Bonato VL; de Camargo AC; Ferro ES; Department of Parasitology, Microbiology, and Immunology, School; of Medicine of Ribeirao Preto, University of Sao Paulo,; Ribeirao Preto, 14049-900, Brazil.
- The initial processing of antigens leading to major histocompatibility complex (MHC) class I antigenic peptides is carried out by the proteasome. However, how the final epitopes are generated and protected from degradation by cytosolic peptidases remains unknown. Coincidentally, peptides associated with the MHC class
- Interaction of the transactivating protein HIV-1 tat with sulphated polysaccharides.
- Biochem Pharmacol. 1999 Apr 1;57(7):775-83. Unique Identifier : AIDSLINE MED/99173378
- Watson K; Gooderham NJ; Davies DS; Edwards RJ; Division of Medicine, Imperial College School of Medicine,; Hammersmith Hospital, London, UK.
- Endogenous sulphated polysaccharides such as heparin have been shown to inhibit the infectivity of HIV-1 min vitro. However, these naturally occurring polymers, due to extensive microheterogeneity within their structure, are difficult to characterise accurately. In contrast, dextrin can be chemically sulphated to prod
- Mechanism of anti-HIV activity of succinylated human serum albumin.
- Biochem Pharmacol. 1999 Apr 15;57(8):889-98. Unique Identifier : AIDSLINE MED/99184126
- Kuipers ME; v.d. Berg M; Swart PJ; Laman JD; Meijer DK; Koppelman MH; Huisman H; Groningen Institute for Drug Studies, The Netherlands.; M.E.Kuipers@farm.rug.nl
- In the present study, we described the interaction of succinylated human serum albumin (Suc-HSA), a negatively charged anti-HIV-1 active protein, with HIV-1 gp120 and in detail with the third variable domain of gp120 (V3 loop). To this end, different assay formats were tested in which gp120- and V3-related peptides we
- Lowering of trichosanthin immunogenicity by site-specific coupling to dextran.
- Biochem Pharmacol. 1999 Apr 15;57(8):927-34. Unique Identifier : AIDSLINE MED/99184131
- Chan WL; Shaw PC; Li XB; Xu QF; He XH; Tam SC; Department of Physiology, The Chinese University of Hong Kong,; Shatin, NT.
- Trichosanthin is a type I ribosome-inactivating protein possessing a broad spectrum of biological and pharmacological activities. Therapeutic use of this compound is hampered by its immunogenicity. It was shown earlier that coupling of dextran to trichosanthin can increase plasma half-life and reduce antigenicity. How
- Core center opens [news]
- Aids Patient Care STDS. 1998 Dec;12(12):893. Unique Identifier : AIDSLINE AIDS/99095172
- Heroin use decreases [news]
- Aids Patient Care STDS. 1998 Dec;12(12):893. Unique Identifier : AIDSLINE AIDS/99095176
- Needle device approved [news]
- Aids Patient Care STDS. 1998 Dec;12(12):893. Unique Identifier : AIDSLINE AIDS/99095174
- NIAID funds research centers [news]
- Aids Patient Care STDS. 1998 Dec;12(12):893. Unique Identifier : AIDSLINE AIDS/99095173
- Per-patient cost stabilizes [news]
- Aids Patient Care STDS. 1998 Dec;12(12):893. Unique Identifier : AIDSLINE AIDS/99095171
- Syringe exchange programs [news]
- Aids Patient Care STDS. 1998 Dec;12(12):893. Unique Identifier : AIDSLINE AIDS/99095175
- AIDS research and its cultural implications.
- Aids Patient Care STDS. 1998 Dec;12(12):895-902. Unique Identifier : AIDSLINE AIDS/99095177
- Laurence J; Laboratory for AIDS Virus Research, Cornell University Medical; College, New York, New York, USA.
- Successful treatment of idiopathic colitis and proctitis using thalidomide in persons infected with human immunodeficiency virus.
- Aids Patient Care STDS. 1998 Dec;12(12):903-6. Unique Identifier : AIDSLINE AIDS/99095178
- Fu CS; Conteas CN; LaRiviere MJ; Division of Gastroenterology, Southern California Permanente; Medical Group, Los Angeles, USA.
- Gastrointestinal ulcerations in persons infected with HIV have many causes, the most common being opportunistic infections and neoplasms. Recently, idiopathic ulcerative lesions of the colon and rectum have been described. Two cases are reported of idiopathic colonic and anorectal inflammation and ulceration which fai
- Failure of a prospective trial to detect cytomegalovirus retinitis after initiation of highly active antiretroviral therapy.
- Aids Patient Care STDS. 1998 Dec;12(12):907-12. Unique Identifier : AIDSLINE AIDS/99095179
- Uphold CR; Smith MF; Bender BS; Department of Nursing, VA Medical Center, Gainesville, Florida,; USA. Upholcr.ufcon@shands.ufl.edu
- Thirty-one patients with AIDS with CD4+ T-cell counts of less than 75/mm3 were enrolled in a prospective study to determine the incidence of cytomegalovirus ( CMV ) retinitis and changes in CD4+ T-cell counts and viral loads fo
- Acute myeloid leukemias, multiple myelomas, and chronic leukemias in the setting of HIV infection.
- Aids Patient Care STDS. 1998 Dec;12(12):913-9. Unique Identifier : AIDSLINE AIDS/99095180
- Pulik M; Genet P; Jary L; Lionnet F; Jondeau K; Service d'Hematologie, Centre Hospitalier d'Argenteuil, France.
- B-cell lineage-derived high-grade malignant lymphomas are a well-recognized complication of HIV infection. However, isolated cases of unusual hematologic malignancies such as acute myeloid leukemias (AML), multiple myeloma (MM) or plasmacytomas, and chronic leukemias have been reported. This review focuses on these un
- Malignant syphilis: a review.
- Aids Patient Care STDS. 1998 Dec;12(12):921-5. Unique Identifier : AIDSLINE AIDS/99095181
- Kumar B; Muralidhar S; Department of Dermatology, Venereology and Leprology,; Postgraduate Institute of Medical Education and Research,; Chandigarh, India.
- Syphilis is a disorder that may mimic many other diseases. Its incidence has risen and fallen over the centuries. A particularly malignant and virulent form, lues maligna, has recently been more frequently observed in the HIV-infected population. Raising the awareness of the occurrence of and the clinical and laborato
- Psychological adjustment and suicidal ideation in patients with AIDS.
- Aids Patient Care STDS. 1998 Dec;12(12):927-30. Unique Identifier : AIDSLINE AIDS/99095182
- Gil F; Passik S; Rosenfeld B; Breitbart W; Psycho-Oncology Unit, Institut Catala d'Oncologia, L'Hospitalet,; Barcelona, Spain.
- This article assesses the psychosocial adjustment to illness and examines the relationship between adjustment and psychosocial and medical variables in 91 ambulatory HIV-infected patients. The 91 subjects were receiving ambulatory medical care in hospitals (Memorial Hospital, New York Hospital, and St. Vincent s Hospi
- A mobile HIV education and testing program: bringing services to hard-to-reach populations.
- Aids Patient Care STDS. 1998 Dec;12(12):931-7. Unique Identifier : AIDSLINE AIDS/99095183
- O'Connor CA; Patsdaughter CA; Grindel CG; Taveira PF; Steinberg JL; East Boston Neighborhood Health Center, East Boston,; Massachusetts, USA.
- Few programs exist that offer a range of human immunodeficiency virus (HIV) services to multiple populations (i.e., substance abusers, individuals on probation, sex workers and their clients, court-mandated perpetrators of domestic violence) in multiple settings (i.e., courts, methadone maintenance clinics, residentia
- Data released on twice-daily dosing study of saquinavir [news]
- Aids Patient Care STDS. 1998 Dec;12(12):939. Unique Identifier : AIDSLINE AIDS/99095184
- Amprenavir made available through early access program [news]
- Aids Patient Care STDS. 1998 Dec;12(12):939-40. Unique Identifier : AIDSLINE AIDS/99095185
- Protease inhibitor-sparing regimen suppresses HIV [news]
- Aids Patient Care STDS. 1998 Dec;12(12):940. Unique Identifier : AIDSLINE AIDS/99095186
- Indinavir gender study shows consistency [news]
- Aids Patient Care STDS. 1998 Dec;12(12):940-1. Unique Identifier : AIDSLINE AIDS/99095187
- Phase III results presented on amprenavir triple combination [news]
- Aids Patient Care STDS. 1998 Dec;12(12):941-2. Unique Identifier : AIDSLINE AIDS/99095188
- Fomivirsen approved [news]
- Aids Patient Care STDS. 1998 Dec;12(12):943. Unique Identifier : AIDSLINE AIDS/99095189
- Mice immunized against chlamydia [news]
- Aids Patient Care STDS. 1998 Dec;12(12):943. Unique Identifier : AIDSLINE AIDS/99095190
- Famvir effective in suppressing recurrent genital herpes [news]
- Aids Patient Care STDS. 1998 Dec;12(12):944. Unique Identifier : AIDSLINE AIDS/99095191
- Phase II clinical trial of VX-497 for HCV infection begins [news]
- Aids Patient Care STDS. 1998 Dec;12(12):944. Unique Identifier : AIDSLINE AIDS/99095192
- Sexual risk behaviors decrease among high school students.
- Aids Patient Care STDS. 1998 Dec;12(12):945-7. Unique Identifier : AIDSLINE AIDS/99095193
- Makulowich GS
- House passes bill to require HIV tests for all Federal inmates.
- AIDS Policy Law. 1998 Aug 21;13(15):1, 6-8. Unique Identifier : AIDSLINE AIDS/99704106
- Legislation to expand HIV testing in Federal prisons was passed by the House of Representatives on August 3, 1998. The legislation, called H.R. 2070, requires testing of all incoming Federal prisoners and of all inmates who expose corrections officers or visitors to bodily fluids. The legislation does not apply to inm
- A suspicion of AIDS is sufficient to trigger exams for food handlers.
- AIDS Policy Law. 1998 Aug 21;13(15):1, 9. Unique Identifier : AIDSLINE AIDS/99704107
- The Michigan Supreme Court has ruled that food handlers suspected of having AIDS can be required by their employers to undergo testing for opportunistic infections. Such employers are obligated by the Public Health Code and by other food-safety regulations to exclude employees who may transmit opportunistic diseases s
- N.J. court upholds conviction of needle swap volunteers.
- AIDS Policy Law. 1998 Aug 21;13(15):2. Unique Identifier : AIDSLINE AIDS/99704108
- A New Jersey appeals court upheld the convictions of Diana McCague and Thomas Scozzare for possessing drug paraphernalia. They were arrested for trying to distribute sterile injection equipment and bleach to an undercover officer who was posing as a drug addict. Although the defendants argued that needle exchanges sav
- Shared snorkel leads to coerced HIV test, suit alleges.
- AIDS Policy Law. 1998 Aug 21;13(15):3. Unique Identifier : AIDSLINE AIDS/99704109
- An African-American mother is suing an Illinois clinic and a community center, alleging that they pressured her into having her son tested for HIV and strep throat because he shared a snorkel with a white boy at a public swimming pool. The mother contends that the community center pressured her because the white boy s
- House votes to eliminate increased funds for HOPWA.
- AIDS Policy Law. 1998 Aug 21;13(15):4-5. Unique Identifier : AIDSLINE AIDS/99704110
- Congress left for the 1998 summer recess without approving a Labor/Health and Human Services appropriations bill for 1999, which is the funding source for most AIDS programs. The Congress is divided on how much to spend on the Housing Opportunities for People with AIDS (HOPWA) program, and in July, the House shifted $
- House seeks end to needle swaps in District of Columbia.
- AIDS Policy Law. 1998 Aug 21;13(15):5. Unique Identifier : AIDSLINE AIDS/99704111
- If the Senate approves a House-passed spending bill that shuts down all needle-exchange programs in the District of Columbia, it may be vetoed by President Clinton. H.R. 4300, an amendment to the District s appropriations bill by Representative Todd Tiahrt, would prohibit any agency receiving Federal funding from oper
- Report urges collaboration on inmate discharge planning.
- AIDS Policy Law. 1998 Aug 21;13(15):8. Unique Identifier : AIDSLINE AIDS/99704112
- A report from the National Institute of Justice and the Centers for Disease Control and Prevention has recommended that prisons do more discharge planning for HIV-positive inmates being released to the community. Public health and correctional agencies should collaborate more in discharge planning and transitional ser
- HIV levels in semen don't match levels in blood.
- AIDS Policy Law. 1998 Aug 21;13(15):8. Unique Identifier : AIDSLINE AIDS/99704113
- At the World AIDS Conference in Geneva, Phalguni Gupta from the University of Pittsburgh reported that viral load tests on semen are necessary to determine the amount of HIV that can be transmitted during risky sexual contact. Forty-four percent of men involved in a 10-week study had semen viral loads that fluctuated
- HIV-positive plaintiff must show job transfer caused harm.
- AIDS Policy Law. 1998 Aug 21;13(15):10. Unique Identifier : AIDSLINE AIDS/99704114
- A teacher in the De Kalb County School District has argued that the district discriminated against him when they transferred him to a different job because he is HIV-positive. The teacher was transferred from a psychoeducational class that was limited to aggressive and violent special-needs students to a classroom of
- Lawmakers introduce bill for name-based notification.
- AIDS Policy Law. 1998 Aug 21;13(15):10-1. Unique Identifier : AIDSLINE AIDS/99704115
- H.R. 4331, an HIV Partner Protection Act introduced by Reps. Gary Ackerman and Tom Coburn, would require that states report the names of people infected with HIV to the health department. In addition, these people would have to tell public health officials the names of current and past sex or needle-sharing partners.
- Family planning clinic ends required HIV testing.
- AIDS Policy Law. 1998 Aug 21;13(15):11. Unique Identifier : AIDSLINE AIDS/99704116
- The Desire/Florida Neighborhood Pregnancy Care Clinic will no longer require an HIV test as a precondition for obtaining free birth control pills. Previously, women who refused to be tested were referred elsewhere, but those who tested positive were not denied services from the clinic. The policy was changed due to pr
- Measuring HIV treatment adherence in clinical practice.
- AIDS Clin Care. 1998 Aug;10(8):57-9. Unique Identifier : AIDSLINE AIDS/99704117
- Hecht FM
- Measuring adherence to HIV treatment regimens is important in determining whether patients will develop undetectable HIV viremia or drug-resistant HIV. A few methods of measurement have shown documented effectiveness. Questioning the patient with specific, nonjudgmental questions is the best method for gaining accurat
- An alarming x-ray in a patient who feels well.
- AIDS Clin Care. 1998 Aug;10(8):60, 64. Unique Identifier : AIDSLINE AIDS/99704118
- Zuger A
- A 27-year-old woman, who is being successfully treated for HIV, has mostly normal results from physical examinations and feels well. Yet she had a chest X-ray that showed prominent perihilar adenopathy and a miliary pattern in all lung fields. Medical records from an open lung biopsy, photographs taken during the biop
- A patient with no options?
- AIDS Clin Care. 1998 Aug;10(8):61, 63-4. Unique Identifier : AIDSLINE AIDS/99704120
- Feinberg J; Henry K; University of Minnesota, School of Medicine, Minneapolis, MN.
- A 44-year-old man diagnosed with HIV in 1992 has become 3TC-resistant, has had adverse effects to ddI, and most likely will have the same adverse effects to d4T and ddC . The
- T-20: new trial enrolling, 9 U.S. cities.
- AIDS Treat News. 1998 Aug 7;(No 300):1-3. Unique Identifier : AIDSLINE AIDS/99704121
- James JS
- Trimeris, Inc. has announced a trial of T-20, an experimental synthetic 36-amino-acid peptide. The study, TRI-003, will enroll 78 volunteers in 9 U.S. cities. Entry into the trial only requires that volunteers have a viral load of 5,000. Earlier trials of the drug showed a very rapid drop in viral load with no known a
- Ritonavir capsule manufacturing problems will require switch to liquid formulation.
- AIDS Treat News. 1998 Aug 7;(No 300):1, 5. Unique Identifier : AIDSLINE AIDS/99704122
- James JS
- Abbott Laboratories has halted production of Ritonavir ( Norvir ) capsules due to a manufacturing problem which caused the drug to crystallize, dis
- New vaccine+HAART treatment trial enrolling at NIH. National Institutes of Health.
- AIDS Treat News. 1998 Aug 7;(No 300):3-4. Unique Identifier : AIDSLINE AIDS/99704123
- James JS
- The National Institutes of Health (NIH) is beginning a trial that includes a new HIV vaccine plus standard antiretroviral therapy, and which may restore HIV immune function in some patients. Volunteers must have a CD4 count of over 500 and either be on treatment or willing to begin treatment. All study medications wil
- Viral load: Roche applies for marketing approval for ultrasensitive test.
- AIDS Treat News. 1998 Aug 7;(No 300):6. Unique Identifier : AIDSLINE AIDS/99704124
- Roche Molecular Systems has applied for FDA permission to market a more sensitive viral load test. The Amplicor HIV-1 Monitor UltraSensitive Method tests viral load as low as 50 copies; current tests are only accurate to 400 copies. There is a widespread consensus among physicians tha
- Medical marijuana: Healing Alternatives begins distribution.
- AIDS Treat News. 1998 Aug 7;(No 300):7-8. Unique Identifier : AIDSLINE AIDS/99704125
- James JS
- Healing Alternatives Foundation will begin medical marijuana distribution in August. Physicians will not prescribe or recommend marijuana use to their patients, but they will need to acknowledge awareness of their patient s medical use of marijuana. The physician will have to confirm the existence of a serious or life
- Nutritional supplements: call for information.
- AIDS Treat News. 1998 Aug 7;(No 300):8. Unique Identifier : AIDSLINE AIDS/99704126
- James JS
- AIDS Treatment News is planning to expand coverage of nutritional supplements and is seeking personal experiences with using these supplements. The distinction that the U.S. draws between what is considered nutrition versus what is considered drugs, interferes with the ability to research nutritional supplements. Most
- The CHORUS database on patient clinical care--and interview with Stephen Becker, M.D. [interview by John S. James]
- AIDS Treat News. 1998 Aug 21;(No 301):1-5. Unique Identifier : AIDSLINE AIDS/99704127
- Becker S
- CHORUS (Collaborations in HIV Outcomes Research - U.S.) is a research database containing information from 6,000 patients across four major U.S. HIV practices. This longitudinal study tracks data generated during regular medical care for the patients. The database is anonymous, and patients submit quarterly questionna
- Major email security flaws discovered: how to protect your data.
- AIDS Treat News. 1998 Aug 21;(No 301):8. Unique Identifier : AIDSLINE AIDS/99704128
- James JS
- AIDS organizations need to pay special attention to possible flaws in email systems that may compromise confidentiality of client information. Three email software programs are singled out as particularly vulnerable. Information for finding instructions on fixing the software programs is provided.
- Funding shortages challenge AIDS drug assistance program.
- Body Posit. 1998 Aug;XI(8):12. Unique Identifier : AIDSLINE AIDS/99704130
- Engle L
- HIV patients who rely on AIDS Drug Assistance Programs (ADAPs) sometimes have limited access to new medical advances, and sometimes are refused entry into the programs due to insufficient funding. Recent treatment advances have increased the number of people seeking HIV treatment and using ADAPs, which has increased t
- Viagra users should be cautious.
- Body Posit. 1998 Aug;XI(8):12. Unique Identifier : AIDSLINE AIDS/99704131
- Engle L
- The Gay and Lesbian Medical Association (GLMA) has expressed concerns about the effects of Viagra on the health of people with HIV. There is no data to show how Viagra interacts with protease inhibitors (PIs), but it is believed that PIs may aggravate some of the si
- International developments.
- Body Posit. 1998 Aug;XI(8):12-3. Unique Identifier : AIDSLINE AIDS/99704132
- Engle L
- Bahrain is the first Arab Gulf country to acknowledge that AIDS exists, and as a result, is starting to offer prevention programs. This is a major step for a part of the world where the subject of AIDS is taboo, and HIV-positive people are treated as outcasts.
- Predicting drug effectiveness.
- Body Posit. 1998 Aug;XI(8):13. Unique Identifier : AIDSLINE AIDS/99704133
- Two new diagnostic tests which evaluate a patient s HIV resistance to antiviral drugs were scheduled to be on the market in July. The tests are being marketed under the trademarks Antivirogram, by Laboratory Corporation of America, and VircoGEN by VIRCO. Both companies say that when the tests are used together, they w
- Hellish conditions at single-room occupancy hotels.
- Body Posit. 1998 Aug;XI(8):18-23 contd. Unique Identifier : AIDSLINE AIDS/99704134
- Foley D
- Poor conditions exist in many of the commercial single-room occupancy (SRO) hotels for people who are HIV-positive. Living conditions are unsanitary, brutal, and dangerous, and occupants often experience harassment from the hotel owners and staff. Many of the occupants are drug abusers or are mentally incapacitated, a
- Medical highlights of the 12th World AIDS Conference.
- Body Posit. 1998 Aug;XI(8):24-31. Unique Identifier : AIDSLINE AIDS/99704135
- Prescott LM
- The underlying theme of the 12th World AIDS Conference in Geneva was that while significant progress has been made in fighting the epidemic worldwide, there are still areas in which the disease is spreading and infection rates are increasing. Some have estimated that 40 million individuals in the developing countries
- Addressing "heat of the moment" thinking that leads to unsafe sex.
- Focus. 1998 Aug;13(9):1-4. Unique Identifier : AIDSLINE AIDS/99704136
- Gold RS; Deakin University, School of Psychology, Victoria, Australia.
- Gay men frequently use self-justification to validate their decision to participate in unprotected anal intercourse. A recent study of 734 men questioned the participant s thought processes when they made the decision to willingly practice behaviors that are unsafe. Researchers studied the responses from these partici
- Clearinghouse: self-justification.
- Focus. 1998 Aug;13(9):4-5. Unique Identifier : AIDSLINE AIDS/99704137
- A bibliography of research articles on self-justification is presented. Topics covered include developing cost-effective media campaigns to address unsafe anal sex among gay men, the thought processes associated with unprotected intercourse in heterosexual couples, prevention campaigns for hard-to-reach populations, a
- Self-reflection as a tool for behavior change.
- Focus. 1998 Aug;13(9):5-6. Unique Identifier : AIDSLINE AIDS/99704138
- Dilley JW
- People at risk for HIV frequently have difficulty maintaining their commitment to safer sex practices and often make decisions to abandon these practices. A randomized long-term study, which includes a one-time counseling intervention, by the UCSF AIDS Health Project is looking at how people use justifications to rati
- Salvage with Nelfinavir doesn't always work.
- Treat Update. 1998 Aug;10(6):2-3. Unique Identifier : AIDSLINE AIDS/99704139
- Nelfinavir does not seem to work well in salvage therapy. Patients who were on PI-containing therapy and who had viral loads that eventually increased, were switched to a new drug combination that included Nelfinavir. Only 30 percent of the patients had their viral load decrease. German and French researchers have con
- Confused fat cells and body shape changes.
- Treat Update. 1998 Aug;10(6):4-5. Unique Identifier : AIDSLINE AIDS/99704140
- A U.S. study of women taking protease inhibitors (PIs) showed that approximately 10 percent complained of body shape changes, primarily in the breast and abdomen, but some also lost weight in arms and/or legs, and had increased pads of fat on their shoulders. One ex
- Anti-HIV drugs and birth defects.
- Treat Update. 1998 Aug;10(6):4-5. Unique Identifier : AIDSLINE AIDS/99704141
- Researchers in New York have been following the effects of AZT on the fetus in pregnant HIV-positive women. A review of 1,315 births to mothers taking AZT found a 9 percent birth defect rate; however, no statistical evidence linked AZT to these defect
- A kinder, gentler approach to treatment. [Interview by Paul Simmons]
- RITA Newsl. 1998 Aug;4(5):3-5. Unique Identifier : AIDSLINE AIDS/99704142
- Mauss S
- Dr. Stefan Mauss, a German physician with the HIV Consortium in Munich, explains his views on treating HIV. His views reflect the skepticism of European physicians about the American model of HIV treatment. Reasons for why he disagrees with the idea of eradication are given, as are his reasons for why treatment should
- From science to reality.
- RITA Newsl. 1998 Aug;4(5):6-8. Unique Identifier : AIDSLINE AIDS/99704143
- Rochon D
- The Geneva Conference on AIDS was more cautious in tone than the Vancouver Conference. The old hit hard, hit early treatment paradigm was questioned in light of the side effects of current drugs and the inability of people to adhere to treatments. The lack of scientific evidence about a drug s efficacy is discussed,
- Dressing up your virus: a new outfit for HIV.
- RITA Newsl. 1998 Aug;4(5):9. Unique Identifier : AIDSLINE AIDS/99704144
- Simmons P
- Antiviral drugs, like any trend, may be in demand one year but passe the next. Saquinavir is an example of this trendiness. Initially, it was in great demand, but within 2 years the side effects had reduced the demand. Efavirenz (
- Rescue me.
- RITA Newsl. 1998 Aug;4(5):10. Unique Identifier : AIDSLINE AIDS/99704145
- Simmons P
- Several presenters at the 12th World AIDS Conference in Geneva provided encouraging clinical data on rescue therapy. One study that examined Ritonavir /Saquinavir rescue therapy reported success if the viral load was low at the time that treatment was
- Open your mouth and close your eyes....
- RITA Newsl. 1998 Aug;4(5):13-4. Unique Identifier : AIDSLINE AIDS/99704146
- Abbott Laboratories has responded to the poor solubility of the capsule form of Norvir ( Ritonavir ) by reintroducing the oral liquid form. The liq
- Simply stated...are people still wasting?
- RITA Newsl. 1998 Aug;4(5):15. Unique Identifier : AIDSLINE AIDS/99704147
- AIDS wasting is seen less than in the past, but it still remains the second most common AIDS-related condition after pneumocystis carinii pneumonia. Several factors contribute to wasting: opportunistic infections, anorexia/low food intake, and poor absorption and diarrhea. Treatment options include appetite stimulants
- Report from the great Chicago plateau.
- PI Perspect. 1998 Apr;(No 24):1-3. Unique Identifier : AIDSLINE AIDS/99704148
- The 5th Conference on Retroviruses and Opportunistic Infections reported that the death rate for AIDS has steadily declined since 1996. The basis for this decrease was debated. A study presented by Tulane School of Medicine showed that improvements of many aspects of the disease may be directly related to the use of
- Antiviral update.
- PI Perspect. 1998 Apr;(No 24):4-5. Unique Identifier : AIDSLINE AIDS/99704149
- Data collected from several studies can provide guidance on new therapies for treatment-experienced patients. A study comparing two different triple-drug combination therapies, both using Indinavir , showed no significant differences in antiviral activ
- Double protease inhibitor combinations.
- PI Perspect. 1998 Apr;(No 24):6-8. Unique Identifier : AIDSLINE AIDS/99704150
- The benefits of using double protease inhibitors , over combination therapies with one protease inhibitor, are discussed. In one study, the treatment arm that used two protease inhibitors with one or more nucleoside analogue reverse transcriptase inhibitors (NARTI) h
- Lower dose maintenance therapy?
- PI Perspect. 1998 Apr;(No 24):9. Unique Identifier : AIDSLINE AIDS/99704151
- Two studies examined the effectiveness of reducing the dosage of anti-HIV medications for patients who have achieved a viral load under 200 copies of HIV RNA. Both studies revealed that the maintenance dosage was not as effective at suppressing viral levels as a triple-drug combination. The results of these studies in
- New drugs on the horizon.
- PI Perspect. 1998 Apr;(No 24):10-3. Unique Identifier : AIDSLINE AIDS/99704152
- Since many new anti-HIV drugs are variations of currently available drugs, they may be more effective for people who are beginning treatment. One study shows favorable results when using efavirenz in triple
- Interleukin-2 (IL-2).
- PI Perspect. 1998 Apr;(No 24):13-5. Unique Identifier : AIDSLINE AIDS/99704153
- Interleukin-2 ( IL-2 ) is being used with highly active antiretroviral therapy (HAART) to stimulate CD4+ cell development in people with HIV. According to Dr. Fauci, Director of the National Institute of Allergy and Infectious Diseases, the use of IL-2 is being explored
- Hydroxyurea - new observations.
- PI Perspect. 1998 Apr;(No 24):15-7. Unique Identifier : AIDSLINE AIDS/99704154
- Hydroxyurea obstructs HIV from reproducing, is effective when combined with nucleoside analogue reverse transcriptase inhibitors, and it is difficult for HIV to develop a resistance to it. The combination of Hydroxyurea and ddI may be effective in targeting the HIV virus that hides in resting cells. This is in contras
- Opportunistic infections update.
- PI Perspect. 1998 Apr;(No 24):17-9. Unique Identifier : AIDSLINE AIDS/99704155
- The reduction in the incidence of opportunistic infections (OIs) can be attributed to the use of highly active antiretroviral therapy (HAART). Several OIs are discussed, including: mycobacterium avium complex, tuberculosis, and pneumocystis carinii pneumonia. At its highest efficacy, HAART causes a positive immune res
- Hepatitis in HIV disease.
- PI Perspect. 1998 Apr;(No 24):20-3. Unique Identifier : AIDSLINE AIDS/99704156
- Hepatitis, an infection in the liver, affects many people with HIV. Hepatitis A (HAV) is transmitted most often through sexual contact with an infected person or by ingesting contaminated food or drinks. Two ways of preventing HAV are by maintaining good personal hygiene or receiving a vaccination. There are no treatm
- Progressive multifocal leukoencephalopathy (PML).
- PI Perspect. 1998 Apr;(No 24):23-4. Unique Identifier : AIDSLINE AIDS/99704157
- Progressive multifocal leukoencephalopathy (PML) is a disease which attacks the brain and produces a rapid demise in patients. PML is more likely to occur in people with vulnerable immune systems, such as AIDS patients. Highly active anti-HIV therapy (HAART) has shown promise in its ability to extend the life of HIV p
- Improved immunogenicity of HIV-1 epitopes in HBsAg chimeric DNA vaccine plasmids by structural mutations of HBsAg.
- DNA Cell Biol. 1999 Mar;18(3):219-25. Unique Identifier : AIDSLINE MED/99196239
- Bryder K; Sbai H; Nielsen HV; Corbet S; Nielsen C; Whalen RG; Fomsgaard A; Department of Virology, Statens Serum Institut, Copenhagen,; Denmark.
- To improve the immunogenicity of epitopes from the envelope protein of HIV-1, we have developed gene gun-delivered subunit DNA vaccines by inserting the sequences encoding the V3 region into the hepatitis B virus (HBV) envelope gene, often called the surface antigen (HBsAg). We have examined the possibility of modifyi
- In pursuit of new developments for gene therapy of human diseases.
- J Biotechnol. 1999 Feb 5;68(1):1-13. Unique Identifier : AIDSLINE MED/99155791
- Palu G; Bonaguro R; Marcello A; Institute of Microbiology, University of Padova, Italy.
- Gene therapy aims at transferring a therapeutic gene into human somatic cells in order to treat a disease. Originally addressed to hereditary genetic disorders, gene therapy has found therapeutic applications in cancer, infectious diseases and degenerative disorders, particularly those of the nervous system. Although
- A multi-mode chromatographic method for the comparison of the N-glycosylation of a recombinant HIV envelope glycoprotein (gp160s-MN/LAI) purified by two different processes.
- J Biotechnol. 1999 Feb 5;68(1):37-48. Unique Identifier : AIDSLINE MED/99155794
- Taverna M; Nguyet TT; Valentin C; Level O; Merry T; Kolbe HV; Ferrier D; Laboratoire de Chimie Analytique, Faculte de Pharmacie,; Chatenay-Malabry, France.
- The glycosylation pattern of a recombinant gp160s-MN/LAI variant of human immunodeficiency virus type 1 (HIV-1) was studied in relation to two alternative purification techniques one of which involves an immunoprecipitation step. For analysis a multi-mode high performance liquid chromatography (HPLC) method which comb
- Modification of the genetic program of human alveolar macrophages by adenovirus vectors in vitro is feasible but inefficient, limited in part by the low level of expression of the coxsackie/adenovirus receptor.
- Am J Respir Cell Mol Biol. 1999 Mar;20(3):361-70. Unique Identifier : AIDSLINE MED/99155237
- Kaner RJ; Worgall S; Leopold PL; Stolze E; Milano E; Hidaka C; Ramalingam R; Hackett NR; Singh R; Bergelson J; Finberg R; Falck-Pedersen E; Crystal RG; Division of Pulmonary and Critical Care Medicine, The New York; Hospital-Cornell Medical Center, New York, New York 10021, USA.; nmohamed@mail.med.cornell.edu
- Robust expression of genes transferred by adenovirus (Ad) vectors depends upon efficient entry of vectors into target cells. Cells deficient in the coxsackie/adenovirus receptor (CAR) are difficult targets for Ad-mediated gene transfer. We hypothesized that low levels of CAR expression may be responsible, in part, for
- Formation of multinucleated giant cells in the mouse lung is promoted in the absence of interleukin-12.
- Am J Respir Cell Mol Biol. 1999 Mar;20(3):371-8. Unique Identifier : AIDSLINE MED/99155238
- Anderson S; Shires VL; Wilson RA; Mountford AP; Department of Biology, The University of York, York, United; Kingdom.
- The formation of multinucleated giant cells (MGCs) in an in vivo model of pulmonary inflammation was investigated to determine whether these cells are the result of a dominant T helper (Th) 1 or Th2 cytokine environment. We report that knockout (KO) mice with a disrupted interleukin (IL)-12 p40 gene exposed to the hel
- Impact of a patient-centered, computer-based health information/support system [see comments]
- Unique Identifier : AIDSLINE MED/99111919
- Gustafson DH; Hawkins R; Boberg E; Pingree S; Serlin RE
- Substance use and risky sexual behavior among homeless and runaway youth.
- J Adolesc Health. 1998 Dec;23(6):378-88. Unique Identifier : AIDSLINE MED/99085879
- Bailey SL; Camlin CS; Ennett ST; Department of Psychiatry, University of Pittsburgh, Pennsylvania; 15213, USA.
- PURPOSE: To (a) characterize human immunodeficiency virus (HIV)-related risk behaviors of homeless youth; (b) determine whether substance use is associated with risky sexual behavior in this population; and, if so, (c) explore explanations for this relationship. METHODS: A purposive sample of 327 homeless youth (ages
- [HIV infection in the health care are of Leon. Incidence from 1983-1997]
- Enferm Infecc Microbiol Clin. 1999 Jan;17(1):19-23. Unique Identifier : AIDSLINE MED/99168262
- Alcoba M; de Castro MR; Guerra JM; Perez MR; Carro JA; Martinez Y; Servicio de Medicina Interna 2, Hospital de Leon.
- BACKGROUND: The aim of the present work was to know the incidence of HIV infection in the sanitary area of Leon, and its tendency, throughout the period 1983-1997. MATERIAL AND METHODS: A register of cases with the patients attended in the area hospitals, those detected in the Penitentiary Centre of Leon and notificat
- [PCR in the diagnosis of focal cerebral lesions in HIV infected patients]
- Enferm Infecc Microbiol Clin. 1999 Jan;17(1):29-35. Unique Identifier : AIDSLINE MED/99168264
- Pujol-Rique M; Miro JM; Amondarain I; Danes C; Valls ME; Servicio de Microbiologia, Institut d'Investigacions; Biomediques August Pi i Sunyer (IDIBAPS)-Hospital Clinic; Universitari, Barcelona.
- [Multivalvular endocarditis caused by Pseudomonas aeruginosa in a patient infected with the human immunodeficiency virus (letter)]
- Enferm Infecc Microbiol Clin. 1999 Jan;17(1):41-2. Unique Identifier : AIDSLINE MED/99168267
- Fombuena M; Garcia M; de Lelis FP; Ballester JE; Garcia M; Valero I; Ortega E; Herrera A
- [Hemophagocytic syndrome associated with tuberculosis in a patient infected with the human immunodeficiency virus (letter)]
- Enferm Infecc Microbiol Clin. 1999 Jan;17(1):43-4. Unique Identifier : AIDSLINE MED/99168269
- Garcia C; Santaolalla P; Gomez C; Pintor E
- [Hydronephrosis caused by indinavir (letter)]
- Enferm Infecc Microbiol Clin. 1999 Jan;17(1):47-8. Unique Identifier : AIDSLINE MED/99168274
- Reus S; Arroyo E; Boix V; Portilla J
- Time-resolved fluorescence investigation of the human immunodeficiency virus type 1 nucleocapsid protein: influence of the binding of nucleic acids.
- Biophys J. 1999 Mar;76(3):1561-70. Unique Identifier : AIDSLINE MED/99158629
- Bombarda E; Ababou A; Vuilleumier C; Gerard D; Roques BP; Piemont E; Mely Y; Laboratoire de Biophysique, URA 491 du CNRS, Faculte de; Pharmacie, Universite Louis Pasteur, B.P. 24, F-67401 Illkirch; Cedex, France.
- Depending on the HIV-1 isolate, MN or BH10, the nucleocapsid protein, NCp7, corresponds to a 55- or 71-amino acid length product, respectively. The MN NCp7 contains a single Trp residue at position 37 in the distal zinc finger motif, and the BH10 NCp7 contains an additional Trp, at position 61 in the C-terminal chain.
- [Blood-borne viral infection in hemodialysis units: special reference to hepatitis B virus, hepatitis C virus and human T-lymphotropic virus type 1]
- Nippon Koshu Eisei Zasshi. 1998 Oct;45(10):960-7. Unique Identifier : AIDSLINE MED/99109342
- Washio M; Department of Public Health, School of Medicine, Kyushu; University.
- Hemodialysis patients are one of the high risk groups for blood-borne viral infection due to their need of blood transfusions for renal anemia. In addition, the hemodialysis procedure itself is a risk factor for blood-borne viral infection. Therefore, prevention of blood-borne infection in hemodialysis units is highly
- [Perioperative therapy of HIV infections]
- Langenbecks Arch Chir Suppl Kongressbd. 1998;115:1107-10. Unique Identifier : AIDSLINE MED/99130598
- Muller FP; Schecter WP; Jablonowski H; Schmidt WU; Verreet PR; Klinik fur Allgemein- und Visceralchirurgie, Krefeld.
- A meta-analysis of the literature demonstrates high operation complication rates in HIV-positive patients. Own experience connected with a general hospital in San Francisco, University of California, indicates that such an analysis provides the surgeon with the possibility of optimizing the treatment of HIV-positive p
- [Chronic liver immunologic factors in ischemic type biliary lesions (ITBL) --> reduced Th1 and increased Th2 response]
- Langenbecks Arch Chir Suppl Kongressbd. 1998;115:1557-9. Unique Identifier : AIDSLINE MED/99130734
- Golling M; Zipperle S; Weimer R; Otto G; Herfarth C; Opelz G; Klar E; Abteilung fur Allgemeine Chirurgie, Universitat Heidelberg.
- Compared to patients with a stable liver function, we found a decreased Th1 and increased Th2 response in patients presenting with ischemic type biliary lesions following liver transplantation. It remains open to speculation whether these immunological changes were induced by the damage of the bile ducts, occur as an
- Unsuccessful association of zidovudine and interferon alpha for acute adult T-cell leukemia lymphoma [letter]
- Dermatology. 1999;198(1):103-5. Unique Identifier : AIDSLINE MED/99152059
- Dega H; Chosidow O; Charlotte F; Frances C; Herson S; Leblond V
- Transfusion of the HIV-seropositive patient: immunomodulation, viral reactivation, and limiting exposure to EBV (HHV-4), CMV (HHV-5), and HHV-6, 7, and 8.
- Transfus Med Rev. 1999 Jan;13(1):1-17. Unique Identifier : AIDSLINE MED/99123835
- Hillyer CD; Lankford KV; Roback JD; Gillespie TW; Silberstein LE; Emory University Hospital Blood Bank, Emory University Hospital,; Atlanta, GA 30322, USA.
- Genetic immunotherapy for medullary thyroid carcinoma: destruction of tumors in mice by in vivo delivery of adenoviral vector transducing the murine interleukin-2 gene.
- Thyroid. 1998 Dec;8(12):1137-46. Unique Identifier : AIDSLINE MED/99117098
- Zhang R; Baunoch D; DeGroot LJ; Department of Medicine, The University of Chicago, Illinois; 60637, USA.
- A replication defective adenovirus harboring the interleukin-2 gene (AdCMVmIL2) was used for treatment of a mouse medullary thyroid carcinoma (mMTC). We evaluated the antitumor effect and immunological response in the animal model. In small tumors (
- Is HIV infection a cofactor for cervical squamous cell neoplasia?
- Cancer Epidemiol Biomarkers Prev. 1999 Jan;8(1):97-106. Unique Identifier : AIDSLINE MED/99133745
- Mandelblatt JS; Kanetsky P; Eggert L; Gold K; Department of Medicine, Lombardi Cancer Center, Georgetown; University, Washington, DC 20007, USA.; Mandelbj@gunet.georgetown.edu
- The objective of this study was to test the hypothesis that HIV interacts with human papilloma virus (HPV) to increase the odds of cervical neoplasia. The study design was a meta-analysis using data pooled from published sources. Studies published between January 1986 and March 1998 were eligible for inclusion if they
- Virus replication begins in dendritic cells during the transmission of HIV-1 from mature dendritic cells to T cells.
- Curr Biol. 1999 Jan 14;9(1):21-9. Unique Identifier : AIDSLINE MED/99108193
- Granelli-Piperno A; Finkel V; Delgado E; Steinman RM; Laboratory of Cellular Physiology and Immunology, The Rockefeller; University, New York 10021-6399, USA.; piperno@rockvax.rockefeller.edu
- BACKGROUND: To initiate immunity, dendritic cells (DCs) capture antigens or viruses at body surfaces, undergo maturation to express T-cell costimulatory molecules, and then migrate to lymphoid organs. DCs at body surfaces can capture human immunodeficiency virus 1 (HIV-1), but mature DCs do not support replication of
- Enhanced fatty streak formation in C57BL/6J mice by immunization with heat shock protein-65.
- Arterioscler Thromb Vasc Biol. 1999 Mar;19(3):505-10. Unique Identifier : AIDSLINE MED/99174098
- George J; Shoenfeld Y; Afek A; Gilburd B; Keren P; Shaish A; Kopolovic J; Wick G; Harats D; Research Unit of Autoimmune Diseases, Department of Medicine,; Institute of Pathology, Sheba Medical Center, Tel Hashomer,; Israel.
- Recent data suggest that the immune system is involved in atherogenesis. Thus, interest has been raised as to the possible antigens that could serve as the initiators of the immune reaction. In the current work, we studied the effects of immunization with recombinant heat shock protein-65 (HSP-65) and HSP-65-rich Myco
- Drug abuse and acquired immune deficiency syndrome.
- Psychiatry Clin Neurosci. 1998 Dec;52 Suppl:S167-9. Unique Identifier : AIDSLINE MED/99110428
- Sheu Y; Medical Affairs, Division of Clinical Research and Services,; National Institute on Drug Abuse, Rockville, Maryland 20857, USA.
- Acquired immune deficiency syndrome (AIDS) is a modern plague. The first sign of the disease was the appearance of Pneumocystis carinii and Kaposi s sarcoma among young homosexual patients. The virus transmission is from an infected individual to a susceptible host through blood-related, sexual, and perinatal routes.
- Vaccine reactions [letter]
- Nat Med. 1998 Jul;4(7):746. Unique Identifier : AIDSLINE MED/98324722
- Francis DP; Nowinski RC
- Vaccine reactions [letter]
- Nat Med. 1998 Jul;4(7):746. Unique Identifier : AIDSLINE MED/98324720
- Mascola JR; McNeil JG; Birx DL
- Vaccine reactions [letter]
- Nat Med. 1998 Jul;4(7):746. Unique Identifier : AIDSLINE MED/98324721
- Yamazaki S
- World Bank will lend more money to India for AIDS [news]
- Nat Med. 1998 Jul;4(7):750. Unique Identifier : AIDSLINE MED/98324726
- Jayaraman KS
- HIV vaccines--and the winner is... [news]
- Nat Med. 1998 Jul;4(7):753. Unique Identifier : AIDSLINE MED/98324730
- Birmingham K
- Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression.
- Nat Med. 1998 Jul;4(7):786-93. Unique Identifier : AIDSLINE MED/98324746
- Mummidi S; Ahuja SS; Gonzalez E; Anderson SA; Santiago EN; Stephan KT; Craig FE; O'Connell P; Tryon V; Clark RA; Dolan MJ; Ahuja SK; Department of Medicine, University of Texas Health Science Center; at San Antonio and South Texas Veterans Health Care System, Audie; L. Murphy Division, 78284-7870, USA.
- Allelic variants for the HIV-1 co-receptors chemokine receptor 5 (CCR5) and CCR2, as well as the ligand for the co-receptor CXCR4, stromal-derived factor (SDF-1), have been associated with a delay in disease progression. We began this study to test whether polymorphisms in the CCR5 regulatory regions influence the cou
- Limited CD4+ T-cell renewal in early HIV-1 infection: effect of highly active antiretroviral therapy.
- Nat Med. 1998 Jul;4(7):794-801. Unique Identifier : AIDSLINE MED/98324747
- Fleury S; de Boer RJ; Rizzardi GP; Wolthers KC; Otto SA; Welbon CC; Graziosi C; Knabenhans C; Soudeyns H; Bart PA; Gallant S; Corpataux JM; Gillet M; Meylan P; Schnyder P; Meuwly JY; Spreen W; Glauser MP; Miedema F; Pantaleo G; Department of Medicine, Centre Hospitalier Universitaire Vaudois,; University of Lausanne, Switzerland.
- We show that the fraction of proliferating CD4+ lymphocytes is similar in HIV-infected subjects in the early stage of disease and in HIV-negative subjects, whereas the fraction of proliferating CD8+ lymphocytes is increased 6.8-fold in HIV-infected subjects. After initiation of antiviral therapy, there is a late incre
- Peripheral expansion of pre-existing mature T cells is an important means of CD4+ T-cell regeneration HIV-infected adults.
- Nat Med. 1998 Jul;4(7):852-6. Unique Identifier : AIDSLINE MED/98324758
- Walker RE; Carter CS; Muul L; Natarajan V; Herpin BR; Leitman SF; Klein HG; Mullen CA; Metcalf JA; Baseler M; Falloon J; Davey RT Jr; Kovacs JA; Polis MA; Masur H; Blaese RM; Lane HC; Clinical and Molecular Retrovirology Section, Laboratory of; Immunoregulation, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, Maryland; 20892, USA.
- The CD4+ T-cell pool in HIV-infected patients is in a constant state of flux as CD4+ T cells are infected and destroyed by HIV and new cells take their place. To study T-cell survival, we adoptively transferred peripheral blood lymphocytes transduced with the neomycin phosphotransferase gene between syngeneic twin pai
- Phosphorothioate hammerhead ribozymes targeting a conserved sequence in the V3 loop region inhibit HIV-1 entry.
- Antisense Nucleic Acid Drug Dev. 1998 Dec;8(6):441-50. Unique Identifier : AIDSLINE MED/99114640
- Zhang X; Iwatani Y; Shimayama T; Yamada R; Koito A; Xu Y; Sakai H; Uchiyama T; Hattori T; Department of Viral Oncology, Institute for Virus Research, Kyoto; University, Japan.
- Seven different phosphorothioate DNA-RNA chimeric hammerhead ribozymes (RzV3-nT, n = 1-7) targeted against the V3 loop region of HIV-1 were synthesized. Two of these, RzV3-1T and RzV3-3T, efficiently cleaved transcribed envelope RNA of HXB2 in vitro. The target sequence of RzV3-1T belongs to a conserved region and is
- Oligonucleotide-mediated inhibition of genomic RNA dimerization of HIV-1 strains MAL and LAI: a comparative analysis.
- Antisense Nucleic Acid Drug Dev. 1998 Dec;8(6):517-29. Unique Identifier : AIDSLINE MED/99114648
- Lodmell JS; Paillart JC; Mignot D; Ehresmann B; Ehresmann C; Marquet R; Institut de Biologie Moleculaire et Cellulaire, CNRS,; Strasbourg, France.
- An essential step in the replication cycle of retroviruses is the dimerization of two copies of the genomic RNA. In vitro and in vivo studies have demonstrated that dimerization is mediated at least partially by RNA-RNA interactions. In HIV-1, the cis-element most important for dimerization is the dimerization initiat
- The effects of prednisone and azathioprine on circulating immunoglobulin levels and lymphocyte subpopulations in normal dogs.
- Can J Vet Res. 1999 Jan;63(1):18-24. Unique Identifier : AIDSLINE MED/99114888
- Rinkardt NE; Kruth SA; Kaushik A; Department of Clinical Studies, University of Guelph, Ontario.
- This study investigates serum immunoglobulin (SIg) levels and lymphocyte subpopulations in normal dogs in response to putative immunosuppressive doses of prednisone and/or azathioprine. The objectives were to quantify SIg levels and lymphocyte subpopulations, including Thy-1+, CD4+, CD8+ and B cells, in normal dogs bo
- Modeling the dynamics of HIV-1 and CD4 and CD8 lymphocytes.
- IEEE Eng Med Biol Mag. 1999 Jan-Feb;18(1):21-4. Unique Identifier : AIDSLINE MED/99133359
- de Souza FM; Departamento de Eletronica e Sistemas, Universidade Federal de; Pemambuco, Recife.
- Increased gene transfer into human CD34+ progenitor cells using retroviral vectors produced by a canine packaging cell line.
- Unique Identifier : AIDSLINE MED/99120284
- Bauer G; Sauter S; Ibanez C; Rice CR; Valdez P; Jolly D; Kohn DB
- Using retroviral supernatants derived from the amphotropic murine packaging cell line PA317 and the amphotropic canine packaging cell line (DA), cord blood and mobilized peripheral blood CD34+ cells were transduced with the vector LN (neomycin resistance) and the vector L-TR/TAT neo (neomycin resistance in conjunction
- Gene therapy approaches to HIV-infection: immunological strategies: use of T bodies and universal receptors to redirect cytolytic T-cells.
- Front Biosci. 1999 Apr 1;4:D386-93. Unique Identifier : AIDSLINE MED/99201495
- Bitton N; Gorochov G; Debre P; Eshhar Z; Laboratoire d Immunologie Cellulaire, CERVI, UMR CNRS 7627,; Hopital Pitie-Salpetriere, 83, Bd. de l Hospital, 75013 Paris,; France.
- Combined regimens of classical antiviral treatments have not, until now, lead to the eradication of HIV-1. A specific anti-HIV immune response may have to be boosted or transferred to patients after suppression of viral replication, in order to eradicate residual infected cells from their sanctuaries. Cytotoxic T cell
- Monitoring of solid phase peptide synthesis by FT-IR spectroscopy.
- J Pept Sci. 1998 Dec;4(8):461-70. Unique Identifier : AIDSLINE MED/99124442
- Henkel B; Bayer E; Institute of Organic Chemistry, University of Tubingen, Germany.
- Aggregation phenomena of growing peptides on the resin have seldom been investigated. We report here how conformations are determined by FT-IR spectroscopy. Therefore the sequence 80-99 of HIV 1-protease was synthesized. After every coupling a resin sample was taken out of the reaction column and a FT-IR spectrum reco
- SPC3, an anti-HIV peptide construct derived from the viral envelope, binds and enters HIV target cells.
- J Pept Sci. 1998 Dec;4(8):479-85. Unique Identifier : AIDSLINE MED/99124444
- Barbouche R; Miquelis R; Sabatier JM; Fenouillet E; CNRS, Faculte de Medecine Nord, Marseille, France.
- SPC3 is a peptide construct (eight branches of the GPGRAF motif) derived from the consensus sequence present at the apex of the third variable domain of the human immunodeficiency virus (HIV) envelope (Env). It presents a potent anti-HIV activity and is currently tested in phase II clinical trials (
- On-site primary care and mental health services in outpatient drug abuse treatment units.
- J Behav Health Serv Res. 1999 Feb;26(1):80-94. Unique Identifier : AIDSLINE MED/99168297
- Friedmann PD; Alexander JA; Jin L; D'Aunno TA; Section of General Internal Medicine, University of Chicago, IL; 60637, USA. pfriedma@medicine.bsd.uchicago.edu
- Providing health services to drug abuse treatment clients improves their outcomes. Using data from a 1995 national survey of 597 outpatient drug abuse treatment units, this article examines the relationship between these units organizational features and the degree to which they provided onsite primary care and menta
- AIDS and mental health -- part II.
- Harv Ment Health Lett. 1999 Apr;15(10):1-4. Unique Identifier : AIDSLINE MED/99192712
- Zidovudine.
- Infect Dis Obstet Gynecol. 1998;6(5):197-203. Unique Identifier : AIDSLINE MED/99111544
- Sperling R; Department of Obstetrics, Gynecology, and Reproductive Sciences,; Mount Sinai Medical Center, New York, NY 10029-6574, USA.; rsperling@smtplink.mssm.edu
- Zidovudine was the first agent approved for treatment of HIV disease, and since its widespread availability in 1987, the pharmacokinetic disposition and clinical effects of ZDV have been extensively evaluated. In addition to its utility as a component of a multidrug combination regimen for the treatment of adult and p
- Determinants of antepartum human immunodeficiency virus testing in a non-Medicaid obstetric population.
- Infect Dis Obstet Gynecol. 1998;6(5):209-13. Unique Identifier : AIDSLINE MED/99111546
- Cardonick E; Daly S; Dooley M; Elles K; Silverman NS; Department of Obstetrics and Gynecology, Jefferson Medical; College of Thomas Jefferson University, Philadelphia, PA, USA.; cardoni1@jeflin.tju.edu
- OBJECTIVE: To determine voluntary human immunodeficiency virus (HIV) testing rates and factors influencing testing in a private obstetric practice. METHODS: Antepartum patients were offered HIV testing after completing a self-assessment questionnaire. Perceived risks and demographics were correlated with testing rates
- Anti-HIV coumarins from Calophyllum seed oil.
- Bioorg Med Chem Lett. 1998 Dec 15;8(24):3475-8. Unique Identifier : AIDSLINE MED/99133218
- Spino C; Dodier M; Sotheeswaran S; Universite de Sherbrooke, Departement de Chimie, Qc., Canada.
- The seeds of Calophyllum cerasiferum Vesque (Family-Clusiaceae), and Calophyllum inophyllum Linn. (Family-Clusiaceae) contain several known coumarins, among which were the potent HIV reverse transcriptase inhibitors costatolide and inophyllum P. Calophyllum cerasiferum contained (-)-calanolide B as its major coumarin
- Potent piperazine hydroxyethylamine HIV protease inhibitors containing novel P3 ligands.
- Bioorg Med Chem Lett. 1998 Dec 15;8(24):3531-6. Unique Identifier : AIDSLINE MED/99133229
- Chen X; Kempf DJ; Sham HL; Green BE; Molla A; Korneyeva M; Vasavanonda S; Wideburg NE; Saldivar A; Marsh KC; McDonald E; Norbeck DW; Pharmaceutical Products Division, Abbott Laboratories, Abbott; Park, Illinois 60064, USA.
- The 2-isopropyl thiazolyl group is a highly optimized P3 ligand for C2 symmetry-based HIV protease inhibitors , as exemplified in the drug ritonavir . Here we report that incorporation of this P3 liga
- Unsymmetric nonpeptidic HIV protease inhibitors containing anthranilamide as a P2' ligand.
- Bioorg Med Chem Lett. 1998 Dec 15;8(24):3537-42. Unique Identifier : AIDSLINE MED/99133230
- Randad RS; Lubkowska L; Eissenstat MA; Gulnik SV; Yu B; Bhat TN; Clanton DJ; House T; Stinson SF; Erickson JW; Structural Biochemistry Program, AIDS Drug Screening and; Development Laboratory, SAIC-Frederick, MD, USA.
- A series of novel unsymmetrical anthranilamide-containing HIV protease inhibitors was designed. The structure-activity studies revealed a series of potent P2-P3 inhibitors that incorporate an anthranilamide group at the P2 position. A reduction in molecular weight
- Tricyclic ureas: a new class of HIV-1 protease inhibitors.
- Bioorg Med Chem Lett. 1998 Dec 15;8(24):3615-20. Unique Identifier : AIDSLINE MED/99133244
- Han W; Pelletier JC; Hodge CN; Department of Chemical and Physical Sciences, DuPont; Pharmaceuticals Company, Wilmington, Delaware 19880-0500, USA.
- A new class of tricyclic ureas containing a conformationally constrained proline was designed with the aid of molecular modeling. Efficient stereoselective intermolecular pinacol coupling represented the highlight of the synthesis. These rigid cyclic ureas are active towards HIV-1 protease, with 9 being the most poten
- Design, synthesis, and conformational analysis of a novel series of HIV protease inhibitors.
- Bioorg Med Chem Lett. 1998 Dec 15;8(24):3631-6. Unique Identifier : AIDSLINE MED/99133247
- Baker CT; Salituro FG; Court JJ; Deininger DD; Kim EE; Li B; Novak PM; Rao BG; Pazhanisamy S; Schairer WC; Tung RD; Vertex Pharmaceuticals Incorporated, Cambridge, MA 02139, USA.
- A combination of structure-based design and both solution, and solid-phase synthesis were utilized to derive a potent (nM) series of HIV-1 protease inhibitors bearing a structurally novel backbone. Detailed structural analysis of several inhibitors prepared in this
- Design and synthesis of novel conformationally restricted HIV protease inhibitors.
- Bioorg Med Chem Lett. 1998 Dec 15;8(24):3637-42. Unique Identifier : AIDSLINE MED/99133248
- Salituro FG; Baker CT; Court JJ; Deininger DD; Kim EE; Li B; Novak PM; Rao BG; Pazhanisamy S; Porter MD; Schairer WC; Tung RD; Vertex Pharmaceuticals Incorporated, Cambridge, MA 02139, USA.
- A set of HIV protease inhibitors represented by compound 2 has previously been described. Structural and conformational analysis of this compound suggested that conformational restriction of the P1/P2 portion of the molecule could lead to a novel set of potent prote
- Clinical forms of human Schistosoma mansoni infection are associated with differential activation of T-cell subsets and costimulatory molecules.
- Dig Dis Sci. 1999 Mar;44(3):570-7. Unique Identifier : AIDSLINE MED/99178237
- Martins-Filho OA; Cunha-Melo JR; Lambertucci JR; Silveira AM; Colley DG; Gazzinelli G; Correa-Oliveira R; Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte, MG,; Brazil.
- The current study has compared the activation status and the expression of the CD28 molecule on circulating CD4+ and CD8+ lymphocytes from patients with different clinical forms of schistosomiasis. The data show that patients with acute schistosomiasis have an increase on the mean percentage of CD4+ HLA-DR+ cells, whe
- Structural characterization of proteins by NMR.
- Dev Biol Stand. 1998;96:37-41. Unique Identifier : AIDSLINE MED/99105520
- Grzesiek S; NIH, National Institute of Diabetes and Digestive and Kidney; Diseases, Bethesda, MD 20892-0510, USA.
- A functional, discontinuous HIV-1 gp120 C3/C4 domain-derived, branched, synthetic peptide that binds to CD4 and inhibits MIP-1alpha chemokine binding.
- FASEB J. 1999 Mar;13(3):503-11. Unique Identifier : AIDSLINE MED/99164117
- Howie SE; Fernandes ML; Heslop I; Hewson TJ; Cotton GJ; Moore MJ; Innes D; Ramage R; Harrison DJ; Department of Pathology, Centre for Protein Technology,; University of Edinburgh, UK. s.e.m.howie@ed.ac.uk
- This paper describes a branched synthetic peptide [3.7] that incorporates sequence discontinuous residues of HIV-1 gp120 constant regions. The approach was to bring together residues of gp120 known to interact with human cell membranes such that the peptide could fold to mimic the native molecule. The peptide incorpor
- Corneal, anterior segment, and adnexal manifestations of human immunodeficiency virus.
- Int Ophthalmol Clin. 1998 Fall;38(4):161-77. Unique Identifier : AIDSLINE MED/99181584
- Acharya NR; Cunningham ET Jr; School of Medicine, University of California, San Francisco; 94143, USA.
- The contribution of various NOS gene products to HIV-1 coat protein (gp120)-mediated retinal ganglion cell injury.
- Invest Ophthalmol Vis Sci. 1999 Apr;40(5):983-9. Unique Identifier : AIDSLINE MED/99200419
- Dreyer EB; Zurakowski D; Gorla M; Vorwerk CK; Lipton SA; Department of Ophthalmology, Scheie Eye Institute, Philadelphia; Veterans Administration, University of Pennsylvania, USA.
- PURPOSE: There is growing evidence that the neuronal pathology seen with HIV-1 is mediated, at least in part, through an excitotoxic/free radical pathway. Nitric oxide (NO) plays a critical role in the nervous system, in both normal and pathologic states, and appears to be involved in a variety of excitotoxic pathways
- Thymic function, aging, and AIDS.
- Hosp Pract (Off Ed). 1999 Mar 15;34(3):59-60, 63-5, 69-70, passim. Unique Identifier : AIDSLINE MED/99189797
- Haynes BF; Hale LP; Department of Medicine, Duke University Medical Center, Durham,; N.C., USA.
- For the first time, physicians are challenged by clinical states in which the T-cell pool is destroyed postnatally in large numbers of patients. One such state is AIDS; another is the immune damage of cancer chemotherapy. Accordingly, study of postnatal thymic function is now a matter of clinical urgency. Ongoing work
- Intracellular adhesion molecule-1 modulates beta-chemokines and directly costimulates T cells in vivo.
- Unique Identifier : AIDSLINE MED/99178891
- Kim JJ; Tsai A; Nottingham LK; Morrison L; Cunning DM; Oh J; Lee DJ; Dang K; Dentchev T; Chalian AA; Agadjanyan MG; Weiner DB
- The potential roles of adhesion molecules in the expansion of T cell-mediated immune responses in the periphery were examined using DNA immunogen constructs as model antigens. We coimmunized cDNA expression cassettes encoding the adhesion molecules intracellular adhesion molecule-1 (ICAM-1), lymphocyte function associ
- Testosterone therapy for human immunodeficiency virus-positive men with and without hypogonadism.
- J Clin Psychopharmacol. 1999 Feb;19(1):19-27. Unique Identifier : AIDSLINE MED/99131638
- Rabkin JG; Wagner GJ; Rabkin R; New York State Psychiatric Institute and Department of; Psychiatry, College of Physicians and Surgeons, Columbia; University, New York 10032, USA. jgr1@columbia.edu
- This study was designed to evaluate the safety and effectiveness of testosterone therapy for clinical symptoms of hypogonadism (low libido, low mood, low energy, loss of appetite/weight) in human immunodeficiency virus-positive men with CD4 cell counts less than 400 cells/mm3 and deficient or low normal serum testoste
- Leukotriene modifiers: new drugs, old and new reactions [editorial; comment]
- J Allergy Clin Immunol. 1999 Mar;103(3 Pt 1):374-5. Unique Identifier : AIDSLINE MED/99169129
- Rosenwasser LJ
- Differential regulation of antigen-induced IL-4 and IL-13 generation from T lymphocytes by IFN-alpha.
- J Allergy Clin Immunol. 1999 Mar;103(3 Pt 1):451-7. Unique Identifier : AIDSLINE MED/99169140
- Essayan DM; Krishnaswamy G; Oriente A; Lichtenstein LM; Huang SK; Division of Clinical Immunology, Department of Medicine, The; Johns Hopkins University School of Medicine, Baltimore, MD, USA.
- BACKGROUND: IL-4 and IL-13 are related cytokines with similar functional properties. Differential regulation of IL-4 and IL-13 has not been described. OBJECTIVE: We have examined the effects of IFN-alpha on antigen-driven proliferation, IL-4 generation, and IL-13 generation from human PBMCs and T-cell clones. METHODS:
- Predominant TH1 cytokine pattern in peripheral blood from subjects with chronic obstructive pulmonary disease.
- J Allergy Clin Immunol. 1999 Mar;103(3 Pt 1):458-62. Unique Identifier : AIDSLINE MED/99169141
- Majori M; Corradi M; Caminati A; Cacciani G; Bertacco S; Pesci A; Istituto di Clinica delle Malattie dell'Apparato Respiratorio; dell'Universita degli Studi, Parma, Italy.
- BACKGROUND: Previous studies have provided evidence for an inflammatory process in the large airways of subjects with chronic obstructive pulmonary disease (COPD), consisting predominantly of activated T cells. No data are available on the TH1 /TH2 T-cell cytokine pattern in this disease. OBJECTIVE: We sought to chara
- Tuberculosis in Louisiana: an update.
- J La State Med Soc. 1998 Dec;150(12):587-95. Unique Identifier : AIDSLINE MED/99125613
- George RB; Farley TA; DeGraw CF; Owens MW; Department of Medicine, LSU School of Medicine-Shreveport, USA.
- The incidence of tuberculosis in the United States declined steadily until 1985 when increases were seen, in part due to the AIDS epidemic. Although the decline resumed in 1992, tuberculosis remains a public health problem in Louisiana and nationally. In Louisiana in 1997, HIV infectio
- Hypocalcaemia in HIV infection and AIDS.
- J Intern Med. 1999 Jan;245(1):69-73. Unique Identifier : AIDSLINE MED/99195523
- Kuehn EW; Anders HJ; Bogner JR; Obermaier J; Goebel FD; Schlondorff D; Medizinische Poliklinik, Ludwig Maximilians University Munchen,; Germany. anneli.ivarsson@epiph.umu.se
- OBJECTIVES: To study the prevalence and possible mechanisms of hypocalcaemia in HIV infection and AIDS. SUBJECTS: 828 patients with HIV infection or AIDS and 549 controls. INTERVENTIONS: Measurements of total serum calcium and albumin levels. Parameters of calcium homeostatis were determined in a subgroup of 21 hypoca
- Supraventricular tachycardia in a human immunodeficiency virus-infected man.
- J Cardiol. 1999 Jan;33(1):21-6. Unique Identifier : AIDSLINE MED/99152812
- Cheng TO; Department of Medicine, George Washington University Medical; Center, Washington, DC 20037, USA.
- Although supraventricular tachycardias and human immunodeficiency virus infections are common diseases by themselves, a combination is not so common. Such a patient was encountered recently and described in this case report. Because misdiagnosis of tachyarrhythmias is not uncommon and may lead to inappropriate therapy
- Reform of legislation covering deliberate transmission of infectious disease [news]
- J R Soc Health. 1998 Apr;118(2):73. Unique Identifier : AIDSLINE MED/99175933
- Shaw A
- International comparison of medical students' perceptions of HIV infection and AIDS.
- J Natl Med Assoc. 1998 Dec;90(12):765-74. Unique Identifier : AIDSLINE MED/99100235
- Najem GR; Okuzu EI; Department of Preventive Medicine and Community Health, UMDNJ-New; Jersey Medical School, Newark 07103-2714, USA.
- This analysis compared medical students perceptions of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) in two cities in two countries with different cultural and educational backgrounds. A total of 292 first- and second-year medical students (45% sample) were surveyed from N
- Multicenter trial to evaluate the safety and potential efficacy of pooled human fibrin sealant for the treatment of burn wounds.
- J Trauma. 1999 Mar;46(3):433-40. Unique Identifier : AIDSLINE MED/99186707
- Greenhalgh DG; Gamelli RL; Lee M; Delavari M; Lynch JB; Hansbrough JF; Achauer BM; Miller SF; MacPhee M; Bray GL; Shriners Hospitals for Children, Northern California, Sacramento; 95817, USA.
- OBJECTIVE: The primary purpose of this multicenter study was to evaluate the safety and potential efficacy of a solvent/detergent-treated commercial fibrin sealant (human) for topical hemostasis in skin grafting. METHODS: The study involved a prospective evaluation of changes in viral titers in patients with burns les
- HIV-risk behaviors in adolescent substance abusers.
- J Subst Abuse Treat. 1999 Mar;16(2):169-72. Unique Identifier : AIDSLINE MED/99147697
- Deas-Nesmith D; Brady KT; White R; Campbell S; Medical University of South Carolina, Center for Drug and Alcohol; Programs, Charleston 29425, USA. deasnesd@musc.edu
- Thirty adolescents aged 12-18 years from each group (substance use disorders, psychiatric disorders, and controls) were assessed to explore HIV-risk behaviors and knowledge about HIV/AIDS. Semi-structured instruments for psychiatric and substance use disorders were also administered. There were no significant differen
- AIDS researchers target poor adherence [news]
- JAMA. 1999 Mar 24-31;281(12):1069. Unique Identifier : AIDSLINE MED/99202526
- Stephenson J
- Genotypic analysis of HIV-1 isolates to identify antiretroviral resistance mutations from source patients involved in health care worker occupational exposures [letter]
- JAMA. 1999 Mar 24-31;281(12):1085-6. Unique Identifier : AIDSLINE MED/99202540
- Tack PC; Bremer JW; Harris AA; Landay AL; Kessler HA; Kuritzkes DR
- [Recent progress in DNA diagnosis of bacteria]
- Nippon Saikingaku Zasshi. 1998 Nov;53(4):621-7. Unique Identifier : AIDSLINE MED/99082588
- Matsuoka Y; Chugai Diagnostics Science Co., LTD., Tokyo.
- Vascular endothelial growth factor (VEGF165) plasma level increase with immunodepression in AIDS patients with Kaposi's sarcoma.
- Microvasc Res. 1999 Mar;57(2):208-10. Unique Identifier : AIDSLINE MED/99160931
- Mercie P; Devianne I; Viallard JF; Faure I; Pellegrin I; Leng B; Dupon M; Barbeau P; Fleury H; Pellegrin JL; Internal Medicine and Infectious Diseases, Haut Leveque; Hospital and Pellegrin Hospital, Bordeaux, France.
- US quest for AIDS vaccine appoints a leader [news]
- Nature. 1999 Mar 18;398(6724):180. Unique Identifier : AIDSLINE MED/99191822
- Wadman M
- [Thalidomide once more in the spotlight (letter)]
- Ned Tijdschr Geneeskd. 1999 Jan 9;143(2):122. Unique Identifier : AIDSLINE MED/99186038
- Bronner GM; Koks CH; Beijnen JH
- Primary dural leiomyosarcoma in a patient infected with human immunodeficiency virus: case report.
- Neurosurgery. 1999 Jan;44(1):199-202. Unique Identifier : AIDSLINE MED/99110273
- Bejjani GK; Stopak B; Schwartz A; Santi R; Department of Neurosurgery, Allegheny General Hospital,; Pittsburgh, Pennsylvania 15212, USA.
- INTRODUCTION: We report the magnetic resonance imaging, angiographic, and immunohistochemical characteristics of a dural leiomyosarcoma in a patient infected with human immunodeficiency virus. METHODS AND RESULTS: A 38-year-old homosexual man presented with a recent history of headaches. Magnetic resonance imaging of
- Postpartum regression rates of antepartum cervical intraepithelial neoplasia II and III lesions.
- Obstet Gynecol. 1999 Mar;93(3):359-62. Unique Identifier : AIDSLINE MED/99173274
- Yost NP; Santoso JT; McIntire DD; Iliya FA; University of Texas Southwestern Medical Center, Dallas, USA.
- OBJECTIVE: To study the histologic regression and progression rates of cervical intraepithelial neoplasia (CIN) II and III after delivery and the effect the route of delivery has on the regression rates of CIN. METHODS: Pregnant patients with satisfactory colposcopic examinations and biopsy-proven CIN II and III were
- Binding of c-Rel to STAT5 target sequences in HTLV-I-transformed T cells.
- Oncogene. 1999 Feb 18;18(7):1401-9. Unique Identifier : AIDSLINE MED/99158164
- Sun SC; Maggirwar SB; Harhaj EW; Uhlik M; Department of Microbiology and Immunology, Pennsylvania State; University College of Medicine, Hershey Medical Center 17033,; USA.
- The type I human T-cell leukemia virus (HTLV-I) induces abnormal growth and subsequent transformation of T cells, which is associated with the development of an acute T-cell malignancy termed adult T-cell leukemia. A characteristic of HTLV-I-transformed T cells is the constitutive nuclear expression of NF-kappaB/Rel f
- Nuclear and nucleolar targeting of human ribosomal protein S25: common features shared with HIV-1 regulatory proteins.
- Oncogene. 1999 Feb 18;18(7):1503-14. Unique Identifier : AIDSLINE MED/99158174
- Kubota S; Copeland TD; Pomerantz RJ; Center for Human Virology, Department of Medicine, Jefferson; Medical College, Thomas Jefferson University, Philadelphia,; Pennsylvania 19107, USA.
- The nuclear and nucleolar targeting properties of human ribosomal protein S25 (RPS25) were analysed by the expression of epitope-tagged RPS25 cDNAs in Cos-1 cells. The tagged RPS25 was localized to the cell nucleus, with a strong predominance in the nucleolus. At the amino terminus of RPS25, two stretches of highly ba
- Immunodeficiency-associated lymphoproliferative disorders.
- Mod Pathol. 1999 Feb;12(2):200-17. Unique Identifier : AIDSLINE MED/99168919
- Knowles DM; Department of Pathology, Cornell University Medical College, New; York, New York, USA.
- The incidence of lymphoproliferative disease is significantly higher in individuals who have congenital, acquired, or iatrogenically induced immunodeficiency. The immunodeficiency-associated lymphoproliferative disorders are clinically and pathologically heterogeneous, are of variable clonal composition, and vary acco
- Nitric oxide in neurodegeneration.
- Prog Brain Res. 1998;118:215-29. Unique Identifier : AIDSLINE MED/99131236
- Dawson VL; Dawson TM; Department of Neurology, Johns Hopkins University School of; Medicine, Baltimore, MD 21287, USA. vdawson@orion.bs.jhmi.edu
- Nitric oxide (NO) is a unique biological messenger molecule which mediates diverse physiologic roles. NO mediates blood vessel relaxation by endothelium, immune activity of macrophages and neurotransmission of central and peripheral neurons. NO is produced from three NO Synthase (NOS) isoforms: Neuronal NOS (nNOS), en
- [HIV and glycosylation]
- Tanpakushitsu Kakusan Koso. 1998 Dec;43(16 Suppl):2567-73. Unique Identifier : AIDSLINE MED/99100141
- Nakata M; Mizuochi T; Department of Applied Chemistry, Tokai University, Kanagawa,; Japan.
- [Cutaneous histoplasmosis in nine patients with AIDS]
- Rev Invest Clin. 1998 Nov-Dec;50(6):525-8. Unique Identifier : AIDSLINE MED/99169378
- Orozco-Topete RL; Reyes E; Departamento de Dermatologia, Instituto Nacional de la; Nutricion Salvador Zubiran, Mexico D.F.
- In AIDS patients the diagnosis of systemic mycosis is a clinical challenge. When cutaneous affection occurs, the diagnosis is difficult because of the non-specific clinical findings. We describe nine patients with AIDS and cutaneous histoplasmosis as the initial clinical manifestation. These patients were diagnosed fr
- [HIV 1998: eradication dreams?]
- Schweiz Med Wochenschr. 1998 Dec 26;128(51-52):2019-22. Unique Identifier : AIDSLINE MED/99149138
- Vernazza PL; Klinik A fur Innere Medizin, Kantonsspital und Institut fur; Klinische Mikrobiologie und Immunologie, St. Gallen.
- AIDS in India: recent trends in opportunistic infections.
- Southeast Asian J Trop Med Public Health. 1998 Jun;29(2):373-6. Unique Identifier : AIDSLINE MED/99101222
- Misra SN; Sengupta D; Satpathy SK; National AIDS Control Organization, New Delhi, India.
- The first case of AIDS in India was reported in 1986. Subsequently, a surveillance system was developed in 1987. The data from this surveillance activity suggest that the HIV infection has now spread to the general population and to all parts of the country, except Arunachal Pradesh
- HIV vaccine development: a subtype E-specific strategy.
- Southeast Asian J Trop Med Public Health. 1998 Jun;29(2):377-82. Unique Identifier : AIDSLINE MED/99101223
- Brown AE; McNeil JG; Armed Forces Research Institute of Medical Sciences, Bangkok,; Thailand.
- The pandemic of HIV/AIDS consists of multiple foci with distinct epidemiological characteristics. Among the approximately one million Southeast Asians infected with HIV, subtype (clade) E infections predominate. This subtype, a recombinant virus comprised of a clade A core (gag) gene and a mosaic clade A/clade E envel
- Toxoplasma gondii antibody in pregnant women with and without HIV infection.
- Southeast Asian J Trop Med Public Health. 1998 Jun;29(2):383-6. Unique Identifier : AIDSLINE MED/99101224
- Chintana T; Sukthana Y; Bunyakai B; Lekkla A; Department of Protozoology, Faculty of Tropical Medicine, Mahidol; University, Bangkok, Thailand.
- One thousand two hundred pregnant women were examined for Toxoplasma gondii antibody with the objective of identifying the prevalence and risk factors of the disease. By using Sabin-Feldman Dye test, the prevalence of IgG to Toxoplasma gondii was 13.2%. In this study 19 cases (1.6%) were anti-HIV seropositive. Between
- [Possible pathogenic role of IL-16 on SLE: with reference to HIV-1 infection]
- Ryumachi. 1998 Oct;38(5):747-51. Unique Identifier : AIDSLINE MED/99069855
- Lee S; Sekigawa I
- Dynamics of co-infection with M. Tuberculosis and HIV-1.
- Theor Popul Biol. 1999 Feb;55(1):94-109. Unique Identifier : AIDSLINE MED/99126627
- Kirschner D; Department of Microbiology and Immunology, The University of; Michigan Medical School, 6730 Medical Science Building II, Ann; Arbor, Michigan, 48109-0620, USA.
- Since 1985, there has been a renewed epidemic of tuberculosis (TB) that was previously thought to be in check. There is evidence to believe the main factor for this resurgence has been the human immunodeficiency virus (HIV). Co-infection with HIV and M. Tuberculosis has profound implications for the course of both dis
- Branched DNA signal amplification for direct quantitation of nucleic acid sequences in clinical specimens.
- Adv Clin Chem. 1998;33:201-35. Unique Identifier : AIDSLINE MED/99186097
- Nolte FS; Department of Pathology and Laboratory Medicine, Emory University; School of Medicine, Atlanta, Georgia, USA.
- In this chapter I have reviewed the development of bDNA as a method for quantitation of nucleic acid targets and the application of this technology to the study of infectious diseases and cell biology. The ability to quantify viral nucleic acids in clinical specimens has led to a better understanding of the pathogenes
- Early- and late-stage Kaposi's sarcoma lesions exhibit similar proliferation fraction.
- Am J Dermatopathol. 1999 Feb;21(1):25-7. Unique Identifier : AIDSLINE MED/99149767
- De Thier F; Simonart T; Hermans P; Andre J; Van Vooren JP; Noel JC; Department of Dermatology, Centre Hospitalier Universitaire St.; Pierre, Brussels, Belgium.
- There are few studies on the proliferative activity of cells in Kaposi s sarcoma. It remains unclear whether the different progressive histologic stages of Kaposi s sarcoma correlate with the proliferative activity of the tumor. To clarify this issue, we studied the Ki-67 proliferation index in 40 specimens of acquire
- Pseudogaucher cells in cutaneous Mycobacterium avium intracellulare infection: report of a case.
- Am J Dermatopathol. 1999 Feb;21(1):51-4. Unique Identifier : AIDSLINE MED/99149774
- Kahn H; Phelps RG; Division of Dermatopathology, Mount Sinai Medical Center, New; York, New York 10029, USA.
- We report on a patient infected with human immunodeficiency virus, and with cutaneous Mycobacterium avium intracellulare, in whom many cells with abundant reticulated cytoplasm resembling the characteristic cells of Gauchers disease ( pseudogaucher cells ) were noted within the dermal infiltrate on biopsy. Although ps
- [HIV/AIDS research. The current status and future prospects]
- Arerugi. 1998 Nov;47(11):1160-2. Unique Identifier : AIDSLINE MED/99109209
- Nagai Y; AIDS Research Center, National Institute of Infectious Diseases,; University of Tokyo.
- [Expression of L-selectin on peripheral memory CD4+ T cells in atopic diseases]
- Arerugi. 1998 Nov;47(11):1168-75. Unique Identifier : AIDSLINE MED/99109211
- Yamashita H; Tanno Y; Tsukuba College of Technology Clinic.
- L-selectin is one of the adhesion molecules, which is known as a leukocyte homing receptor. L-selectin contributes labile rolling adhesion of leukocytes on the blood vessel wall. To elucidate characteristics of L-selectin expression on peripheral CD4+ lymphocytes in atopic diseases, flow cytometric analysis was perfor
- Detection of human retrovirus 5 in patients with arthritis and systemic lupus erythematosus.
- Arthritis Rheum. 1999 Mar;42(3):448-54. Unique Identifier : AIDSLINE MED/99186628
- Griffiths DJ; Cooke SP; Herve C; Rigby SP; Mallon E; Hajeer A; Lock M; Emery V; Taylor P; Pantelidis P; Bunker CB; du Bois R; Weiss RA; Venables PJ; Institute of Cancer Research, Chester Beatty Laboratories,; London, UK.
- OBJECTIVE: To examine whether human retrovirus 5 (HRV-5) infection is associated with autoimmune rheumatic disease. METHODS: DNA from patients with various disorders including inflammatory diseases and from normal subjects was tested by nested polymerase chain reaction (PCR) for HRV-5 proviral DNA. Positive results we
- Diffuse infiltrative lymphocytosis syndrome in a patient with anti-52-kd Ro/SSA and human immunodeficiency virus type 1.
- Arthritis Rheum. 1999 Mar;42(3):578-80. Unique Identifier : AIDSLINE MED/99186646
- Hansen A; Feist E; Hiepe F; Burmester GR; Scholze J; Charite University Hospital, Berlin, Germany.
- T helper-2 type of interleukins with de novo germinal center formation in the spleen during murine pregnancy.
- Am J Reprod Immunol. 1998 Dec;40(6):424-30. Unique Identifier : AIDSLINE MED/99111938
- Hegde UC; Nainan R; Institute for Research in Reproduction, Parel, Mumbai, India.
- PROBLEM: Murine pregnancy is characterized by transient thymic atrophy and splenomegaly. Although some reports on the thymus are available, little is known about the role of the spleen. In the present study, sequential changes in the spleen have been evaluated during murine syngeneic pregnancy. METHOD OF STUDY: Format
- Peripheral neuropathy with nucleoside antiretrovirals: risk factors, incidence and management.
- Drug Saf. 1998 Dec;19(6):481-94. Unique Identifier : AIDSLINE MED/99094700
- Moyle GJ; Sadler M; Kobler Clinic, Chelsea and Westminster Hospital, London, England.
- Distal symmetrical peripheral neuropathy is a common adverse experience in persons with HIV infection. This condition, which presents as a pain, numbness. burning and/or dysaethesia initially in the feet, is often multi-factorial in its origin. Nucleoside analogue rev
- The association between CD2+ peripheral blood lymphocyte subsets and the relapse of bladder cancer in prophylactically BCG-treated patients.
- Br J Cancer. 1999 Mar;79(7-8):1162-7. Unique Identifier : AIDSLINE MED/99196388
- Reyes E; Carballido J; Manzano L; Molto L; Olivier C; Alvarez-Mon M; Department of Medicine, University Hospital Principe de Asturias,; University of Alcala, Madrid, Spain.
- We investigated the potential existence of differences in the distribution of T-lymphocyte subsets and in the proliferative response of these CD2+ cells to polyclonal mitogens in patients with transitional cell bladder carcinoma (SBTCC) treated with prophylactic intracavitary instillations of bacillus Calmette-Guerin
- Interferon-gamma plays a role in pancreatic islet-cell destruction of reovirus type 2-induced diabetes-like syndrome in DBA/1 suckling mice.
- Int J Exp Pathol. 1998 Oct;79(5):313-20. Unique Identifier : AIDSLINE MED/99209394
- Hayashi T; Morimoto M; Iwata H; Onodera T; Laboratory of Veterinary Pathology, Yamaguchi University, Japan.
- Reovirus type 2 (Reo-2) infection in DBA/1 suckling mice causes insulitis, which leads to pancreatic islet-cell destruction, resulting in a diabetes-like syndrome. T-helper (Th) 1 cytokines are thought to play a key role in islet inflammation in insulin-dependent diabetes mellitus. We examined this hypothesis in the R
- IL4 production and increased CD30 expression by a unique CD8+ T-cell subset in B-cell chronic lymphocytic leukaemia.
- Br J Haematol. 1999 Mar;104(3):589-99. Unique Identifier : AIDSLINE MED/99184603
- de Totero D; Reato G; Mauro F; Cignetti A; Ferrini S; Guarini A; Gobbi M; Grossi CE; Foa R; Immunopharmacology Division, Advanced Biotechnology Centre,; National Institute for Cancer Research, Genoa, Italy.; gobbi@unige.it
- Phenotypic and functional abnormalities within the residual non-B-cell compartment of B-cell chronic lymphocytic leukaemia (CLL) suggest an interaction between tumour cells and host immune effectors. To explore the possibility of a polarized Th1/Th2 response we have studied CD30 antigen expression and the pattern of c
- Detection of porcine reproductive and respiratory syndrome virus by reverse transcription-polymerase chain reaction using different regions of the viral genome.
- J Vet Diagn Invest. 1999 Jan;11(1):27-33. Unique Identifier : AIDSLINE MED/99122596
- Guarino H; Goyal SM; Murtaugh MP; Morrison RB; Kapur V; Department of Veterinary Diagnostic Medicine, College of; Veterinary Medicine, University of Minnesota, St. Paul 55108,; USA.
- Serologic studies have revealed strain variability between American and European isolates and among American isolates of porcine reproductive and respiratory syndrome virus (PRRSV). The objective of this study was to develop an assay for the routine diagnosis of PRRSV in field specimens using reverse transcription-pol
- T lymphocyte activation in myasthenic thymoma.
- Autoimmunity. 1998;28(3):173-82. Unique Identifier : AIDSLINE MED/99083019
- Takahashi K; Saito S; Monden Y; The Second Department of Surgery, School of Medicine, The; University of Tokushima, Japan.
- The functional and phenotypic characteristics of lymphocytes separated from myasthenic thymoma (Th-L) were compared with those of lymphocytes separated from non-thymomatous thymus associated with thymoma (NTh-L) of the same patients and NTh-L of myasthenia gravis (MG) patients without thymoma. We examined whether Th-L
- The kinetics of cancer cells and of HIV1: the problems of cell and virus rebounds and of latency [editorial]
- Biomed Pharmacother. 1998;52(10):413-20. Unique Identifier : AIDSLINE MED/99119977
- Mathe G
- The kinetics of non treated and especially of treated HIV1 is compared to that of non treated and of treated cancer cells. Contrary to Skipper s scheme, based on constancy of cancer cell proliferation or post-chemotherapy decrease slope, the same chemotherapy successive cycles decrease in fact less and less the propor
- Structure and function of HIV-1 and SIV Tat proteins based on carboxy-terminal truncations, chimeric Tat constructs, and NMR modeling.
- Biomed Pharmacother. 1998;52(10):421-30. Unique Identifier : AIDSLINE MED/99119978
- Baier-Bitterlich G; Tretiakova A; Richardson MW; Khalili K; Jameson B; Rappaport J; Institute for Medical Chemistry and Biochemistry University of; Innsbruck, Austria.
- To further define the structure and function of the domains in HIV-1 and SIV Tat proteins, chimeric Tat cDNA expression constructs were generated with crossover points at the carboxy-terminal end of the cysteine rich domain. The chimera containing the amino-terminal region of SIV and carboxy-terminal region of HIV exh
- A prophylactic and therapeutic AIDS vaccine containing as a component the innocuous Tat toxoid.
- Biomed Pharmacother. 1998;52(10):431-5. Unique Identifier : AIDSLINE MED/99119979
- Le Buanec H; Lachgar A; Bizzini B; Zagury JF; Rappaport J; Santagostino E; Muca-Perja M; Gringeri A; Laboratoire de Physiologie Cellulaire, Universite P et M Curie,; Paris, France.
- Extracellular Tat can act as a viral toxin on uninfected cells of different tissues, including the CNS and the immune system, thus in order to immunize humans against Tat we have prepared a biologically inactivated but immunogenic Tat (Tat Toxoid). Tat Toxoid is not toxic in mice even at high doses. It triggers high l
- Binding of HIV-1 to RBCs involves the Duffy antigen receptors for chemokines (DARC).
- Biomed Pharmacother. 1998;52(10):436-9. Unique Identifier : AIDSLINE MED/99119980
- Lachgar A; Jaureguiberry G; Le Buenac H; Bizzini B; Zagury JF; Rappaport J; Zagury D; Laboratoire de Physiologie Cellulaire, Universite P et M Curie,; Paris, France.
- The Duffy Antigen Receptor for Chemokines (DARC) belongs to a family of erythrocyte chemokine receptors that bind C-X-C and C-C chemokines such as interleukin 8 (IL-8), monocyte chemoattractant protein 1 (MCP-1) and regulated-on-activation, normal T cell-expressed and -secreted (RANTES), but not macrophage inflammator
- Epidemiology, etiology and pathogenesis, clinical presentations and therapeutic approaches in Kaposi's sarcoma: 15-year lessons from AIDS.
- Biomed Pharmacother. 1998;52(10):440-6. Unique Identifier : AIDSLINE MED/99119981
- Hermans P; Service des Maladies Infectieuses, Centre Hospitalier; Universitaire St-Pierre, Brussels, Belgium.
- Kaposi s sarcoma (KS) is a leading cause of morbidity among 25-30% of AIDS patients and is by far the most common AIDS-associated malignancy. Since the beginning of the 1990s the incidence of KS continuously declined, but it was the introduction of protease inhibitors
- Effect of RANTES on the infection of monocyte-derived primary macrophages by human immunodeficiency virus type 1 and type 2.
- Biomed Pharmacother. 1998;52(10):447-53. Unique Identifier : AIDSLINE MED/99119982
- Ylisastigui L; Amzazi S; Bakri Y; Vizzavona J; Vita C; Gluckman JC; Benjouad A; ESA 7087 Universite Paris 6, Centre Nationale de la Recherche; Scientifique, Hopital de la Pitie-Salpetriere, Paris, France.
- The effect of beta chemokines on human immunodeficiency virus type 1 (HIV-1) infection of primary macrophages is controversial, and their effect on HIV-2 infection of these cells has not yet been documented. We examined the effect of synthetic and recombinant regulated-on-activation, normal T cell-expressed and secret
- Backbone and C beta assignments of the anti-gp120 antibody Fv fragment complexed with an antigenic peptide [letter]
- J Biomol NMR. 1999 Feb;13(2):193-4. Unique Identifier : AIDSLINE MED/99169966
- Tugarinov V; Levy R; Dahan-Schokoroy A; Anglister J
- Detection of Mycoplasma genus and Mycoplasma fermentans by PCR in patients with Chronic Fatigue Syndrome.
- FEMS Immunol Med Microbiol. 1998 Dec;22(4):355-65. Unique Identifier : AIDSLINE MED/99094537
- Vojdani A; Choppa PC; Tagle C; Andrin R; Samimi B; Lapp CW; Immunosciences Laboratory, Beverly Hills, CA 90211, USA.; immunsi@ix.netcom.com
- Mycoplasma fermentans and other Mycoplasma species are colonizers of human mucosal surfaces and may be associated with human immunodeficiency virus infection. While many infectious agents have been described in different percentages of patients with Chronic Fatigue Syndrome (CFS), little is known about the prevalence
- Tuberculosis in patients infected with the human immunodeficiency virus.
- Monaldi Arch Chest Dis. 1998 Dec;53(6):688-92. Unique Identifier : AIDSLINE MED/99162833
- Gerard M; CHU Saint-Pierre, Division of Infectious Diseases, Brussels,; Belgium.
- Nontuberculous mycobacteria and human infections.
- Monaldi Arch Chest Dis. 1998 Dec;53(6):693-6. Unique Identifier : AIDSLINE MED/99162834
- Van Vooren JP; Chest Dept, Erasme Hospital, Brussels, Belgium.
- Animal pneumocystosis: a model for man.
- Vet Res. 1999 Jan-Feb;30(1):1-26. Unique Identifier : AIDSLINE MED/99180950
- Cere N; Polack B; Laboratoire de pathologie du lapin, Institut national de la; recherche agronomique, Nouzilly, France. cere@tours.inra.fr
- Pneumocystis carinii is an important pulmonary pathogen responsible for morbidity and mortality in patients with AIDS. Apart from AIDS, cases of pneumocystosis have been reported in patients receiving immunosuppressive therapy associated with organ transplantation without chemoprophylaxis and in malignant blood diseas
- A reminder [letter]
- J Wound Ostomy Continence Nurs. 1998 Sep;25(5):225-6. Unique Identifier : AIDSLINE MED/99122010
- Jeter KF
- HIV infection and periodontal diseases.
- Periodontol 2000. 1998 Oct;18:37-46. Unique Identifier : AIDSLINE MED/99216718
- Holmstrup P; Westergaard J
- Infectious and tropical diseases affecting the human mouth.
- Periodontol 2000. 1998 Oct;18:47-70. Unique Identifier : AIDSLINE MED/99216719
- Scully C; Monteil R; Sposto MR
- Pseudomonas aeruginosa outer-membrane protein F epitopes are highly immunogenic in mice when expressed on a plant virus.
- Microbiology. 1999 Jan;145 ( Pt 1):211-20. Unique Identifier : AIDSLINE MED/99140153
- Brennan FR; Jones TD; Gilleland LB; Bellaby T; Xu F; North PC; Thompson A; Staczek J; Lin T; Johnson JE; Hamilton WD; Gilleland HE Jr; Axis Genetics plc, Babraham, Cambridge, UK.
- A synthetic peptide (peptide 10) representing a surface-exposed, linear B cell epitope from outer-membrane (OM) protein F of Pseudomonas aeruginosa was shown previously to afford protection in mice from P. aeruginosa infection. This peptide was expressed in tandem with the protein F peptide 18 on each of the two coat
- Aberrant positioning of trophoblast and lymphocytes in the feto-maternal interface with pre-eclampsia.
- Virchows Arch. 1999 Mar;434(3):207-11. Unique Identifier : AIDSLINE MED/99204574
- Stallmach T; Hebisch G; Orban P; Lu X; Pediatric and Developmental Pathology, Department of Pathology,; University Hospital Zurich, Switzerland.; thomas.stallmach@pty.usz.ch
- Pregnancy represents the growth of an allograft where fetal trophoblast cells evade immune rejection and invade maternal tissue. There should be a balance between fetal trophoblast and maternal immune-responsive cells and alterations in the proportion of these cells may relate to pregnancy disorders. To test this, the
- Human herpesvirus 8 (HHV-8) in familial Kaposi's sarcoma.
- Exp Dermatol. 1999 Feb;8(1):68-70. Unique Identifier : AIDSLINE MED/99140250
- Kempf W; Perniciaro C; Adams V; Mueller B; Burg G; Department of Dermatology, University Hospital of Zurich,; Switzerland.
- Human herpesvirus 8 (HHV-8) has been detected in various epidemiological forms of Kaposi s sarcoma (KS). Since familial KS cases are exceedingly rare and the occurrence of familial KS in siblings has thought to depend rather on genetic factors than on a viral factor, familial KS has not been investigated for the prese
- Potential confusion with antiretroviral drugs [letter]
- Am J Health Syst Pharm. 1998 Dec 15;55(24):2639-40. Unique Identifier : AIDSLINE MED/99087738
- Kakuda TN; Acosta EP; Fletcher CV
- Selective enhancement of production of IgE, IgG4, and Th2-cell cytokine during the rebound phenomenon in atopic dermatitis and prevention by suplatast tosilate.
- Ann Allergy Asthma Immunol. 1999 Mar;82(3):293-5. Unique Identifier : AIDSLINE MED/99192034
- Kimata H; Department of Allergy, Unitika Central Hospital, Uji-City, Kyoto; Prefecture, Japan.
- BACKGROUND: Atopic dermatitis is a chronic inflammatory skin disease, which is commonly treated with topical steroids. It is, however, associated with rebound after therapy has been discontinued. OBJECTIVE: This study was designed to elucidate the mechanisms of the rebound phenomenon, and to test the effect of an oral
- Burkitt-like lymphoma presenting as a periodontal disease in AIDS patients: a report of two cases.
- Oral Dis. 1998 Dec;4(4):281-4. Unique Identifier : AIDSLINE MED/99216715
- Nittayananta W; Apinawatavorngul S; Chungpanich S; Pongpanich S; Kietthubthew S; Department of Stomatology, Faculty of Dentistry, Prince of; Songkla University, Thailand.
- Burkitt-like lymphoma of the oral cavity is relatively uncommon in patients with acquired immunodeficiency syndrome (AIDS). The lesion usually appears as a solitary ulcerated mass with rapid onset. Some may present initially as gingival inflammation which delays final diagnosis and treatment. This report describes the
- South Africa plans home-grown HIV vaccine [news]
- Nat Med. 1999 Mar;5(3):252. Unique Identifier : AIDSLINE MED/99184171
- Birmingham K
- Fusion of monocytes and macrophages with HIV-1 correlates with biochemical properties of CXCR4 and CCR5.
- Nat Med. 1999 Mar;5(3):303-8. Unique Identifier : AIDSLINE MED/99184190
- Lapham CK; Zaitseva MB; Lee S; Romanstseva T; Golding H; Division of Viral Products, Center for Biologics Evaluation and; Research, Food and Drug Administration, Bethesda, Maryland 20892,; USA. Lapham@CBER.FDA.GOV
- Human macrophages can be infected more efficiently by M-tropic than by T-tropic HIV-1 strains, despite surface expression of both CXCR4 and CCR5 co-receptors. Western blot analyses of total cell extracts and surface proteins from multiple sets of monocytes and macrophages demonstrated substantial differences between C
- CCR5- and CXCR4-tropic HIV-1 are equally cytopathic for their T-cell targets in human lymphoid tissue.
- Nat Med. 1999 Mar;5(3):344-6. Unique Identifier : AIDSLINE MED/99184198
- Grivel JC; Margolis LB; Laboratory of Molecular and Cellular Biophysics, National; Institute of Child Health and Human Development, National; Institutes of Health, Bethesda, Maryland 20892, USA.
- A rapid decline in T-cell counts and the progression to AIDS is often associated with a switch from CCR5-tropic (R5) HIV-1 to CXCR4-tropic (X4) HIV-1 or R5/X4 HIV-1 variants. Experimental infection with R5 HIV-1 causes less T-cell depletion than infection with X4 or R5/X4 variants in T-cell cultures, in ex vivo infect
- Induction of specific CD8+ T-lymphocyte responses using a human papillomavirus-16 E6/E7 fusion protein and autologous dendritic cells.
- Cancer Res. 1999 Mar 15;59(6):1184-7. Unique Identifier : AIDSLINE MED/99194208
- Murakami M; Gurski KJ; Marincola FM; Ackland J; Steller MA; Section of Gynecologic Oncology, Surgery Branch, Division of; Clinical Sciences, National Cancer Institute, Bethesda, Maryland; 20892, USA.
- When intracellular viral proteins are degraded, only a limited number of peptide epitopes are capable of eliciting specific CD8+ cellular immune responses for a given human leukocyte antigen (HLA) haplotype. We sought to induce CD8+ T-lymphocyte (CTL) responses to human papillomavirus-16 (HPV-16) E6 and E7 proteins us
- The systemic treatment of AIDS-related Kaposi's sarcoma.
- Cancer Treat Rev. 1998 Dec;24(6):415-24. Unique Identifier : AIDSLINE MED/99205406
- Schwartsmann G; Stefani S; Villarroel RU; South-American Office for Anticancer Drug Development (SOAD),; Medical Oncology Unit, Academic Hospital (HCPA), Federal; University of Rio Grande do Sul, Porto Alegre, Brazil.
- Insights into the mechanisms of vertical transmission of HIV-1. BIOMED2 Working Group on the in utero transmission of HIV-1.
- Early Pregnancy. 1997 Dec;3(4):245-58. Unique Identifier : AIDSLINE MED/99185994
- Menu E; Mognetti B; Moussa M; Nardese V; Tresoldi L; Tscherning C; Mbopi Keou FX; Dubanchet S; Mauclere P; Fenyo EM; Scarlatti G; Barre-Sinoussi F; Chaouat G; Equipe de Biologie de la Relation Materno Foetale (Unite 131; INSERM), Maternite, Hopital Antoine Beclere, Clamart.
- This paper is a summary of three oral presentations, as well as the ensuing discussion, at the Rijeka/Opatija 3rd Alps Adria Immunology meeting by three members of the European Biomed group on vertical transmission of HIV (G. Chaouat, F. Barre-Sinoussi, G. Scarlatti). This group also involves the laboratories of D. Do
- Virological efficacy and plasma drug concentrations of nelfinavir plus saquinavir as salvage therapy in HIV-infected patients refractory to standard triple therapy.
- Eur J Med Res. 1999 Feb 25;4(2):54-8. Unique Identifier : AIDSLINE MED/99167820
- Reiser M; Salzberger B; Stiepel A; Hoetelmans R; Diehl V; Fatkenheuer G; First Department of Internal Medicine, University Hospital Koeln,; Joseph-Stelzmann-Str. 9, D-50924 Koeln, Germany.; Marcel.Reiser@uni-koeln.de
- Therapeutic options are limited for patients refractory to triple therapy with two reverse transcriptase inhibitors and one protease inhibitor. Preliminary results showing favorable effects of protease inhibitor combination therapy with nelfinavir and saquinavir due to
- Seroprevalence of human immunodeficiency virus type 1 infection in childhood malignancy in Zimbabwe.
- Cent Afr J Med. 1998 Oct;44(10):242-5. Unique Identifier : AIDSLINE MED/99201648
- Chitsike I; Siziya S; Department of Paediatrics and Child Health, University of; Zimbabwe Medical School, Avondale, Harare, Zimbabwe.
- OBJECTIVES: To determine the association between malignancy and the Human Immunodeficiency Virus type 1 (HIV-1) infection in children. DESIGN: Case series. SETTING: The Paediatric Oncology Unit at Parirenyatwa Teaching Hospital. SUBJECTS: 76 consecutive newly diagnosed cases of malignancy between May 15 and November 1
- Nutritional status of HIV-1 seropositive patients in the Free State Province of South Africa--laboratory parameters.
- Cent Afr J Med. 1998 Oct;44(10):246-50. Unique Identifier : AIDSLINE MED/99201649
- van Staden AM; Barnard HC; Nel M; Attwood EM; Oosthuizen GM; Dannhauser A; van der Ryst E; le Roux GD; Department of Internal Medicine, University of the Orange Free; State, Bloemfontein, South Africa. gninmvs@med.uovs.ac.za
- OBJECTIVE: To evaluate the nutritional status of HIV-1 seropositive patients with regards to laboratory parameters; the correlation between nutrient intake and actual values of nutrients, as well as the relationship between malnutrition and disease progression. DESIGN: A cross sectional study. SETTING: The Immunology
- Investigations into the cross-reactivity of rabbit antibodies raised against nonhomologous pairs of synthetic peptides derived from HIV-1 gp120 proteins.
- J Pept Res. 1998 Nov;52(5):410-20. Unique Identifier : AIDSLINE MED/99110137
- Krsmanovic V; Biquard JM; Sikorska-Walker M; Cosic I; Desgranges C; Trabaud MA; Whitfield JF; Durkin JP; Achour A; Hearn MT; Centre de Genetique Moleculaire et Cellulaire, CNRS UMR 106,; Universite Claude Bernard Lyon I, Villeurbanne, France.
- The immunological cross-reactivity of several peptides with specific pattern-property characteristics related to the epitopes of human immunodeficiency virus type 1 (HIV-1) gp160/ 120 envelope proteins has been investigated. Proteins with similar primary structures can be expected to show functional or topographic sim
- Improved survival among HIV-infected patients after initiation of triple-drug antiretroviral regimens [see comments]
- CMAJ. 1999 Mar 9;160(5):659-65. Unique Identifier : AIDSLINE MED/99202228
- Hogg RS; Yip B; Kully C; Craib KJ; O'Shaughnessy MV; Schechter MT; Montaner JS
- BACKGROUND: The efficacy of triple-drug antiretroviral regimens in the treatment of patients infected with HIV has been established in several randomized clinical trials. However, the effectiveness of these new regimens in patient populations outside clinical trials remain unproven. This study compared mortality and A
- HIV clinical trials are not enough [editorial; comment]
- CMAJ. 1999 Mar 9;160(5):669-70. Unique Identifier : AIDSLINE MED/99202229
- Millson ME; Rachlis AR
- Cost no object as new agency tries to restore blood system's credibility.
- CMAJ. 1999 Mar 9;160(5):699-700. Unique Identifier : AIDSLINE MED/99202233
- Hass J
- The rotavirus vaccine.
- J Clin Virol. 1998 Dec;11(3):155-9. Unique Identifier : AIDSLINE MED/99135110
- Offit PA; Section of Infectious Diseases, Children's Hospital of; Philadelphia, University of Pennsylvania School of Medicine, USA.; offit@email.chop.edu
- BACKGROUND: Rotavirus gastroenteritis is an important cause of morbidity and mortality worldwide. OBJECTIVES: To review the biology, immunology, and virology of rotavirus infections and describe the efforts towards the construction of vaccines using human and animal rotaviruses. STUDY DESIGN: A review of the literatur
- Distribution of CD4+ T-lymphocytes levels in patients with clinical symptoms of AIDS in three west African countries.
- J Clin Virol. 1998 Dec;11(3):173-81. Unique Identifier : AIDSLINE MED/99135112
- Adu-Sarkodie Y; Sangare A; d'Almeida OA; Kanmogne GD; Komfo Anokye Teaching Hospital, Kumasi, Ghana.
- OBJECTIVES: To study the CD4 T-lymphocyte distribution in patients with clinical signs suggestive of AIDS in West Africa. DESIGN AND METHODS: Selected patients had clinical AIDS, according to the WHO clinical definition of AIDS in Africa. Serum samples were tested for the presence of HIV antibodies with two different
- Amplicor HIV monitor, NASBA HIV-1 RNA QT and quantiplex HIV RNA version 2.0 viral load assays: a Canadian evaluation.
- J Clin Virol. 1998 Dec;11(3):189-202. Unique Identifier : AIDSLINE MED/99135114
- Prud'homme IT; Kim JE; Pilon RG; Minkus T; Hawley-Foss N; Cameron W; Rud EW; National Laboratory for HIV Reference Services, Bureau of; HIV/AIDS, STD and TB, LCDC, HPB, Health Canada, Tunney's Pasture,; Ottawa, Ontario, Canada.
- BACKGROUND: HIV-1 viral load quantitation is now recognized as a useful tool to monitor the efficiency of antiviral treatment and a powerful predictor of disease outcome. Three HIV-1 viral load quantitation methods have been currently available as commercial kits in Canada since 19
- Isoelectricfocusing and reverse blotting as a diagnostic tool in pediatric HIV infection.
- J Clin Virol. 1998 Dec;11(3):203-10. Unique Identifier : AIDSLINE MED/99135115
- del Bono V; Biselli R; Nisini R; Loomis-Price LD; Loy A; Lorusso C; Bassetti D; D'Amelio R; I Clinica Malattie Infettive, Universita di Genova, Italy.
- BACKGROUND: Early diagnosis of perinatally acquired HIV-infection is based on either direct HIV detection--by means of viral culture and/or PCR--or anti-HIV antibody detection. However, due to the passive, transplacental passage of maternal immunoglobulin G, antibody detection is nor reliable until 15-18 months of age
- Urinary nucleosides.
- Mass Spectrom Rev. 1998 May-Jun;17(3):131-251. Unique Identifier : AIDSLINE MED/99195561
- Schram KH; Department of Pharmacology and Toxicology, College of Pharmacy,; University of Arizona, Tucson 85721, USA.
- The methods of analysis, origins, and clinical significance of urinary nucleosides are reviewed through 1997. Structures, chromatographic and mass spectral data and references to the clinical literature are presented for each of the 57 nucleosides currently identified in normal and pathogenic human urine samples. Data
- Thalidomide in children undergoing bone marrow transplantation: series at a single institution and review of the literature.
- Pediatrics. 1999 Apr;103(4):e44. Unique Identifier : AIDSLINE MED/99205390
- Mehta P; Kedar A; Graham-Pole J; Skoda-Smith S; Wingard JR; Department of Pediatrics, University of Florida College of; Medicine Gainesville, FL 32610-5633, USA.
- Thalidomide has one of the most notorious drug histories because of its teratogenicity. Its widespread use in the 1960s led to a worldwide epidemic of phocomelia in inborns; this in turn led to its complete ban in most of the world. However, it has now been licensed for selected indications including graft-versus-host
- A phase I study of abacavir (1592U89) alone and in combination with other antiretroviral agents in infants and children with human immunodeficiency virus infection. AIDS Clinical Trials Group 330 Team.
- Pediatrics. 1999 Apr;103(4):e47. Unique Identifier : AIDSLINE MED/99205393
- Kline MW; Blanchard S; Fletcher CV; Shenep JL; McKinney RE Jr; Brundage RC; Culnane M; Van Dyke RB; Dankner WM; Kovacs A; McDowell JA; Hetherington S; Department of Pediatrics, Baylor College of Medicine and Texas; Children's Hospital, Houston, Texas 77030, USA.
- OBJECTIVES: To evaluate the pharmacokinetic features, safety, and tolerance of abacavir, given alone and in combination with other nucleoside antiretroviral agents, in symptomatic human immunodeficiency virus (HIV)-infected children. METHODS: HIV-infected children discontinued prior antiretroviral therapy and were giv
- The fidelity of reverse transcription differs in reactions primed with RNA versus DNA primers.
- J Biomed Sci. 1999 Mar-Apr;6(2):121-32. Unique Identifier : AIDSLINE MED/99189403
- Oude Essink BB; Berkhout B; Department of Human Retrovirology, Academic Medical Center,; University of Amsterdam, The Netherlands.
- Reverse transcriptase enzymes (RT) convert single-stranded retroviral RNA genomes into double-stranded DNA. The RT enzyme can use both RNA and DNA primers, the former being used exclusively during initiation of minus- and plus-strand synthesis. Initiation of minus-strand DNA synthesis occurs by extension of a tRNA pri
- Serodiagnosis of histoplasmosis, paracoccidioidomycosis and penicilliosis marneffei; current status and future trends.
- Med Mycol. 1998 Dec;36(6):351-64. Unique Identifier : AIDSLINE MED/99140352
- Hamilton AJ; Dunhill Dermatology Unit, St John's Institute of Dermatology,; Guy's Hospital, London, UK.
- Effective serodiagnosis of systemic fungal infections is of increasing importance, particularly with regard to the identification of infection with Histoplasma capsulatum, Paracoccidioides brasiliensis and Penicillium marneffei. Methodology has been based either around antibody or antigen detection, although there is
- Unusual pulmonary manifestations of disseminated Penicillium marneffei infection in three AIDS patients.
- Med Mycol. 1998 Dec;36(6):429-32. Unique Identifier : AIDSLINE MED/99140363
- Cheng NC; Wong WW; Fung CP; Liu CY; Department of Medicine, Veterans General Hospital-Taipei, Taiwan,; Republic of China.
- Penicillium marneffei is a rare fungal pathogen which can cause human infections in people predominantly living in South-east Asia and the southern portion of China . We report three cases of systemic P. marneffei infection in patients infected with HIV who lived in or had travelled
- In vitro activity of five antifungal agents against clinical isolates of Saccharomyces cerevisiae.
- Med Mycol. 1998 Dec;36(6):437-40. Unique Identifier : AIDSLINE MED/99140365
- Barchiesi F; Arzeni D; Compagnucci P; Di Francesco LF; Giacometti A; Scalise G; Institute of Infectious Diseases and Public Health of the; University of Ancona, Italy. cmalinf@popcsi.unian.it
- We evaluated the in vitro activity of fluconazole, itraconazole, ketoconazole, 5-fluorocytosine and amphotericin B against 30 clinical isolates of Saccharomyces cerevisiae by a broth microdilution method, following the NCCLS recommendation. Testing was performed either in RPMI-1640 or yeast nitrogen base (YNB). YNB su
- Are there cytopathic features associated with cytomegalovirus infection predictive of resistance to antiviral therapy?
- Ann Diagn Pathol. 1999 Feb;3(1):19-22. Unique Identifier : AIDSLINE MED/99145655
- Anwar F; Erice A; Jessurun J; Department of Medicine, Fairview-University Medical Center,; Minneapolis, MN 55455, USA.
- Recent awareness of the broader spectrum of morphologic changes induced by cytomegalovirus ( CMV ) infection prompted us to investigate whether the concurrent introduction of effective antiviral therapy is in some way related t
- Unrecognized sexually transmitted infections in rural South African women: a hidden epidemic.
- Bull World Health Organ. 1999;77(1):22-8. Unique Identifier : AIDSLINE MED/99163144
- Wilkinson D; Abdool Karim SS; Harrison A; Lurie M; Colvin M; Connolly C; Sturm AW; Centre for Epidemiological Research in South Africa, Medical; Research Council, Mtubatuba, South Africa.
- Sexually transmitted infections (STIs) are of major public health concern in developing countries, not least because they facilitate transmission of human immunodeficiency virus (HIV). The present article presents estimates of the prevalence, on any given day, of STIs among women in rural
- AIDS shortens life and dents economic growth across Africa [news]
- Bull World Health Organ. 1999;77(1):95. Unique Identifier : AIDSLINE MED/99163154
- Costimulatory pathways mediate monocyte-dependent lymphocyte apoptosis in HIV.
- Clin Immunol. 1999 Mar;90(3):302-12. Unique Identifier : AIDSLINE MED/99177394
- Lewis DE; Ng Tang DS; Wang X; Kozinetz C; Department of Microbiology and Immunology, Texas Children's; Hospital, Houston, Texas 77030, USA. dlewis@bcm.tmc.edu
- Examination of annexin V binding, an indicator of early apoptosis, on lymphocytes from HIV+ people immediately after isolation showed that both CD4(+) and CD8(+) T cells were apoptotic, whereas B cell apoptosis was induced mainly after incubation. CD8(+) T cell apoptosis correlated with fewer CD4(+) T cells, but not t
- Autoantibodies to leukocyte alphaMbeta2 integrin glycoproteins in HIV infection.
- Clin Immunol. 1999 Mar;90(3):352-9. Unique Identifier : AIDSLINE MED/99177399
- Rubinstein DB; Farrington GK; O'Donnell C; Hartman KR; Wright DG; Section of Hematology and Oncology, Boston University School of; Medicine, Boston, Massachusetts 02118, USA.
- HIV infection is often associated with polyclonal B-cell activation, autoantibodies, and clinically evident autoimmune disease. Because neutropenia and anti-neutrophil autoantibodies are common clinical features of HIV disease, we studied a series of HIV+ patients to determine whether anti-alphaMbeta2 integrin (MAC-1)
- T cell mediated immunity to Mycobacterium tuberculosis.
- Curr Opin Microbiol. 1999 Feb;2(1):89-93. Unique Identifier : AIDSLINE MED/99158957
- Stenger S; Modlin RL; Institut fuer Klinische Mikrobiologie, Immunologie und Hygiene; Universitaet Erlangen D-91054 Erlangen Germany.
- Recent advances in the characterization of the protective immune response to mycobacteria have highlighted the central role of phenotypically and functionally distinct subsets of T cells. These T cell subsets not only contribute to host defense by the secretion of macrophage-activating cytokines, but also by lysing th
- Thalidomide's tightly controlled "comeback".
- Cleve Clin J Med. 1999 Mar;66(3):136-8. Unique Identifier : AIDSLINE MED/99179298
- Calabrese LH; Department of Rheumatic and Immunologic Diseases, Cleveland; Clinic, USA.
- Thalidomide has anti-inflammatory properties and shows promise for treating a variety of infectious and autoimmune diseases, but it must be used with strict precautions.
- Knee arthroplasty in hemophilic arthropathy.
- Unique Identifier : AIDSLINE MED/99201538
- Thomason HC 3rd; Wilson FC; Lachiewicz PF; Kelley SS; Department of Orthopaedic Surgery, University of North Carolina,; Chapel Hill 27599, USA.
- Twenty-three total knee arthroplasties in 15 patients with severe hemophilia were performed between February 1974 and September 1988. Thirteen patients had Factor VIII deficiency and two had Factor IX deficiency. The mean followup period was 7.5 years, with a minimum of 4 years for patients who were alive (eight) at t
- Endoprosthetic reconstruction for malignant upper extremity tumors.
- Clin Orthop. 1999 Mar;(360):207-20. Unique Identifier : AIDSLINE MED/99201543
- Asavamongkolkul A; Eckardt JJ; Eilber FR; Dorey FJ; Ward WG; Kelly CM; Wirganowicz PZ; Kabo JM; Department of Orthopaedic Surgery, University of California, Los; Angeles School of Medicine 90095-6902, USA.
- Between December 1980 and December 1992, 59 patients underwent 60 reconstructions with endoprostheses after resection of malignant tumors in the upper extremity. There were 32 male patients and 27 female patients, with a mean age of 33 years (range, 3-83 years). The type of reconstruction was based on the location of
- Rationale and design of the Tanzania Vitamin and HIV Infection Trial.
- Control Clin Trials. 1999 Feb;20(1):75-90. Unique Identifier : AIDSLINE MED/99149747
- Fawzi WW; Msamanga GI; Spiegelman D; Urassa EJ; Hunter DJ; Department of Nutrition, Harvard School of Public Health, Boston,; Massachusetts 02115, USA.
- We present the rationale and design of a randomized, double-blind, placebo-controlled trial of vitamin supplements among HIV-positive pregnant women in Dar es Salaam, Tanzania . Higher levels of intake of vitamins A, B, C, and E may decrease the risk of vertical transmission and p
- Cryptococcal lung disease in patients without HIV infection [editorial; comment]
- Chest. 1999 Mar;115(3):610-1. Unique Identifier : AIDSLINE MED/99181952
- Sarosi GA
- Pulmonary cryptococcosis in patients without HIV infection [see comments]
- Chest. 1999 Mar;115(3):734-40. Unique Identifier : AIDSLINE MED/99181976
- Aberg JA; Mundy LM; Powderly WG; AIDS Clinical Trials Unit, San Francisco General Hospital AIDS; Program, University of California 94110, USA.; jaberg@sfaids.ucsf.edu
- PURPOSE: To further elucidate the diagnostic and therapeutic approaches to patients with pulmonary cryptococcosis who are not HIV-infected. SUBJECTS: All of the patients without HIV infection who received care at two Midwest hospitals between January 1986 and February 1996 and had a respiratory isolate of Cryptococcus
- Pulmonary malacoplakia associated with Rhodococcus equi infection in a patient with AIDS.
- Chest. 1999 Mar;115(3):889-92. Unique Identifier : AIDSLINE MED/99182002
- Shin MS; Cooper JA Jr; Ho KJ; Department of Radiology, University of Alabama School of; Medicine, Birmingham, USA.
- An AIDS patient with a cavitary lung lesion was found to have pulmonary malacoplakia associated with Rhodococcus equi infection. The diagnosis was based on the typical histologic features of transbronchial biopsy and a positive bacterial culture. All 13 reported cases of AIDS patients with pulmonary malacoplakia were
- The mercy of adrenocortical tumor cells on lymphocytes.
- Endocr Res. 1998 Aug-Nov;24(3-4):711-6. Unique Identifier : AIDSLINE MED/99103638
- Wolkersdorfer GW; Marx C; Lohmann T; Brauer S; Schroder S; Brown J; Mitsiades N; Chrousos GP; Bornstein SR; Department of Internal Medicine, University of Leipzig, Germany.
- Immunologic escape includes the loss of Fas-receptor and the gain of Fas-ligand expression. Normal adrenal glands express the Fas-receptor and MHC class II molecules in inner cortical zones. A distinctive feature of adrenocortical tumors is the loss of MHC class II expression. Here we demonstrate loss of Fas and gain
- Establishment of persistent infection with HIV-1 abrogates the caspase-3-dependent apoptotic signaling pathway in U937 cells.
- Exp Cell Res. 1999 Mar 15;247(2):514-24. Unique Identifier : AIDSLINE MED/99167428
- Tanaka Y; Kameoka M; Ota K; Itaya A; Ikuta K; Yoshihara K; Department of Biochemistry, Nara Medical University, Nara,; Kashihara, 634, Japan. ytanaka@naramed-u.ac.jp
- Treatment of 26L cells, a subclone obtained from U937 cells, with TNF-alpha or DNA-damaging agents such as teniposide (VM26) and camptothecin (CPT) induced morphologically and biochemically typical apoptotic changes, including the activation of procaspase-3. The cells persistently infected with HIV-1 (26L/HIV), howeve
- Analysis of Tax-expressing cell lines generated from HTLV-I tax-transgenic mice: correlation between c-myc overexpression and neoplastic potential.
- Exp Cell Res. 1999 Mar 15;247(2):525-33. Unique Identifier : AIDSLINE MED/99167429
- Saggioro D; D'agostino DM; Chieco-Bianchi L; Department of Oncology and Surgical Sciences-Oncology Section,; Interuniversity Center for Cancer Research, University of Padova,; Padova, 35128, Italy. saggioro@ux1.unipd.it
- Human T-cell leukemia/lymphotropic virus type I (HTLV-I) infection causes a variety of human diseases, including adult T-cell leukemia/lymphoma. The viral transactivator Tax has been implicated as a key factor in the HTLV-I-induced transformation pathway. To investigate the components of this pathway, we derived fibro
- Intercellular traffic of human immunodeficiency virus type 1 transactivator protein defined by monoclonal antibodies.
- FEBS Lett. 1999 Feb 19;445(1):53-6. Unique Identifier : AIDSLINE MED/99166903
- Demirhan I; Chandra A; Hasselmayer O; Chandra P; Gustav-Embden Center of Biological Chemistry, Department of; Molecular Biology, Frankfurt University Medical School, Germany.
- Monoclonal antibodies (mAbs) directed against the amino-terminal region (N-terminal sequence 2-19) of transactivator protein (tat) of HIV-1 have been shown to inhibit intercellular transactivation mediated by the extracellular tat protein. The intracellular transactivation was not significantly affected by anti-tat mA
- Arginine-aminoglycoside conjugates that bind to HIV transactivation responsive element RNA in vitro.
- FEBS Lett. 1999 Feb 19;445(1):73-9. Unique Identifier : AIDSLINE MED/99166907
- Litovchick A; Evdokimov AG; Lapidot A; Department of Organic Chemistry, The Weizmann Institute of; Science, Rehovot, Israel.
- HIV gene expression is crucially dependent on binding of the viral Tat protein to the transactivation RNA response element. A number of synthetic Tat-transactivation responsive element interaction inhibitors of peptide/peptoid nature were described as potential antiviral drug prototypes. We present a new class of pept
- Receptor mediated apoptosis of CD8+T cells by the B subunits of cholera-like enterotoxins.
- Biochem Soc Trans. 1998 Nov;26(4):S338. Unique Identifier : AIDSLINE MED/99157382
- Pitman RS; Hirst TR; Nashar TO; Williams NA; Department of Pathology and Microbiology, School of Medical; Sciences, University of Bristol, UK.
- Antiviral action & tissue uptake of AZT-sterol dicarboxylates.
- Biochem Soc Trans. 1998 Nov;26(4):S390. Unique Identifier : AIDSLINE MED/99157434
- Bailey JM; Nelson KA; Lightfoote M; Mook RA; Dept. of Biochemistry, George Washington University Medical; School, Washington, DC, USA.
- Are latex gloves a contributing cause of percutaneous injury in dentists?
- Gen Dent. 1998 Sep-Oct;46(5):467-72. Unique Identifier : AIDSLINE MED/99218770
- Neiburger EJ; Center for Dental AIDS Research, Waukegan, Illinois, USA.
- Fifty dentists were examined to determine if (and how) latex gloves contributed to percutaneous injury, the leading cause of occupational AIDS/HIV transmission in health care workers. Latex glove wear is closely associated with a 16-fold increase in percutaneous injury with endodontic file manipulation than when subje
- [Post-exposure prophylaxis. What to do when nosocomial infection by HBV, HCV or HIV is suspected?]
- Fortschr Med. 1999 Jan 30;117(3):18-20. Unique Identifier : AIDSLINE MED/99187595
- Gurtler L; Instituts fur Med. Mikrobiologie der Univ. Greifswald.
- [Action in cases of puncture injury by infected material]
- Fortschr Med. 1999 Jan 30;117(3):22-4. Unique Identifier : AIDSLINE MED/99187596
- Gurtler L; Institut fur Medizinische Mikrobiologie, Universitat; Greifswald.
- Phenotypic and cytotoxic characteristics of peripheral T-cell and NK-cell lymphomas in relation to Epstein-Barr virus association.
- Unique Identifier : AIDSLINE MED/99133343
- Chan AC; Ho JW; Chiang AK; Srivastava G
- AIMS: We investigated the phenotypic and cytotoxic characteristics of different types of peripheral T-cell and NK-cell lymphomas and correlated the findings of cytotoxic phenotype with Epstein-Barr virus (EBV) association. METHODS AND RESULTS: Eighty cases of peripheral T-cell and NK-cell lymphomas, classified accordi
- Synthesis and anti-HIV activity of some non-nucleoside 2,3-disubstituted quinazoline derivatives (Part-V).
- Indian J Exp Biol. 1998 Dec;36(12):1280-3. Unique Identifier : AIDSLINE MED/99193473
- Desai NC; Undavia NK; Trivedi PB; Dave D; Vyas GD; Department of Chemistry, Bhavnagar University, India.
- Several [2-phenyl-4(3H)-oxo-3-quinazolinylamino]-N-substituted- arylacetamides (1a-j) have been synthesized and tested at the National Cancer Institute, Bethesda, Maryland, USA, for their anti-HIV activity against susceptible human host cells (CEM cell line) over a wide range of concentrations (6.35 x 10(-8) to 2.00 x
- Thrombotic microangiopathies and HIV infection: report of two typical cases, features of HUS and TTP, and review of the literature.
- Infection. 1999 Jan-Feb;27(1):12-5. Unique Identifier : AIDSLINE MED/99151162
- Sutor GC; Schmidt RE; Albrecht H; Medizinische Hochschule Hannover, Zentrum Innere Medizin,; Germany.
- Haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are thrombotic microangiopathies increasingly reported in patients with HIV infection. However, characteristic features of thrombotic microangiopathies associated with HIV disease have not been defined yet. The typical courses of HUS and T
- Human herpesvirus 8 primary infection occurs during childhood in Cameroon, Central Africa.
- Unique Identifier : AIDSLINE MED/99202600
- Gessain A; Mauclere P; van Beveren M; Plancoulaine S; Ayouba A; Essame-Oyono JL; Martin PM; de The G; Departement des Retrovirus, Institut Pasteur, Paris, France.; agessain@pasteur.fr
- While in the United States and northern Europe, human herpesvirus 8 (HHV-8) appears to be mainly sexually transmitted with primary infection occurring in adulthood, the modes of transmission remain unknown in East and Central Africa, where Kaposi s sarcoma (KS) is a long-standing endem
- A review of statistical methods for estimating the risk of vertical human immunodeficiency virus transmission.
- Int J Epidemiol. 1998 Dec;27(6):1064-7. Unique Identifier : AIDSLINE MED/99146809
- Dunn DT; Department of Epidemiology and Public Health, Institute of Child; Health, London, UK.
- BACKGROUND: Estimation of the risk of vertical transmission of human immunodeficiency virus (HIV) has been complicated by the lack of a reliable diagnostic test for paediatric HIV infection. METHODS: A literature search was conducted to identify all statistical methods that have been used to estimate HIV vertical tran
- Demographic, clinical and social factors associated with human immunodeficiency virus infection and other sexually transmitted diseases in a cohort of women from the United Kingdom and Ireland. MRC Collaborative Study of women with HIV.
- Int J Epidemiol. 1998 Dec;27(6):1068-71. Unique Identifier : AIDSLINE MED/99146810
- Madge S; Phillips AN; Griffioen A; Olaitan A; Johnson MA; Department of Thoracic Medicine, Royal Free Hospital, London, UK.
- BACKGROUND: Clinical experience suggests many women with HIV infection have experienced no other sexually transmitted diseases (STD). Our objective was to test the hypothesis that a substantial proportion of women with HIV infection in the United Kingdom and
- Pregnancy, body weight and human immunodeficiency virus infection in African women: a prospective cohort study in Kigali (Rwanda), 1992-1994. Pregnancy and HIV Study Group (EGE).
- Int J Epidemiol. 1998 Dec;27(6):1072-7. Unique Identifier : AIDSLINE MED/99146811
- Ladner J; Castetbon K; Leroy V; Nyiraziraje M; Chauliac M; Karita E; De Clercq A; Van de Perre P; Dabis F; Medical Information Unit, Centre Hospitalier de Kigali, Rwanda.
- OBJECTIVE: To study the relationship between human immunodeficiency virus (HIV) infection and body weight in African women during and after pregnancy. METHODS: A prospective cohort study was initiated at the Centre Hospitalier de Kigali in July 1992. Every woman seen at the antenatal clinic and with a gestational age
- Incidence of acquired immunodeficiency syndrome (AIDS)-related Kaposi's sarcoma in the Aquitaine Cohort, France, 1988-1996. Groupe d'Epidemiologie Clinique du SIDA en Aquitaine.
- Int J Epidemiol. 1998 Dec;27(6):1078-82. Unique Identifier : AIDSLINE MED/99146812
- Dupon M; Marimoutou C; Cazorla C; Binquet C; Chene G; Pellegrin JL; Dutronc H; Nouts C; Dabis F; Centre d'Information et de Soins de l'Immunodeficience Humaine,; Centre Hospitalier Universitaire, Bordeaux, France.
- OBJECTIVE: To assess secular trends of the incidence of Kaposi s sarcoma (KS) between 1988 and 1996 in the Aquitaine Cohort of human immunodeficiency virus type 1 (HIV1)-infected subjects (southwestern France ). METHODS: Adults of both sexes of all HIV-transmission categories were i
- Completeness of HIV reporting in Louisiana, USA [letter]
- Int J Epidemiol. 1998 Dec;27(6):1105. Unique Identifier : AIDSLINE MED/99146816
- Klevens RM; Fleming PL; Gaines CG; Troxler S
- Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines.
- J Biol Chem. 1999 Mar 12;274(11):7095-102. Unique Identifier : AIDSLINE GENBANK/L35264
- Hu MC; Wang YP; Mikhail A; Qiu WR; Tan TH; Department of Cell Biology, Amgen, Inc., Thousand Oaks,; California 91320, USA. Mickey_Hu_99@yahoo.com
- The p38 mitogen-activated protein kinases (MAPK) play a crucial role in stress and inflammatory responses and are also involved in activation of the human immunodeficiency virus gene expression. We have isolated the murine cDNA clones encoding p38-delta MAPK, and we have localized the p38-delta gene to mouse chromosom
- Tat-associated kinase (P-TEFb): a component of transcription preinitiation and elongation complexes.
- J Biol Chem. 1999 Mar 12;274(11):7399-404. Unique Identifier : AIDSLINE MED/99167508
- Ping YH; Rana TM; Department of Pharmacology, Robert Wood Johnson Medical School,; and Molecular Biosciences Graduate Program at Rutgers University,; Piscataway, New Jersey 08854, USA.
- Human immunodeficiency virus, type 1 (HIV-1) Tat protein activates transcription from the HIV-1 long terminal repeat. Tat interacts with TFIIH and Tat-associated kinase (a transcription elongation factor P-TEFb) and requires the carboxyl-terminal domain of the largest subunit of RNA polymerase II (pol II) for transact
- Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection.
- J Clin Invest. 1999 Feb;103(4):453-60. Unique Identifier : AIDSLINE MED/99146958
- Haynes BF; Hale LP; Weinhold KJ; Patel DD; Liao HX; Bressler PB; Jones DM; Demarest JF; Gebhard-Mitchell K; Haase AT; Bartlett JA; Department of Medicine, Duke Center for AIDS Research, Duke; University Medical Center, Durham, North Carolina 27710, USA.; Hayne002@mc.duke.edu
- A key question in understanding the status of the immune system in HIV-1 infection is whether the adult thymus contributes to reconstitution of peripheral T lymphocytes. We analyzed the thymus in adult patients who died of HIV-1 infection. In addition, we studied the clinical course of HIV-1 infection in three patient
- Protease inhibitor-induced lipodystrophy.
- J Am Acad Dermatol. 1999 Apr;40(4):635-6. Unique Identifier : AIDSLINE MED/99202572
- Williamson K; Reboli AC; Manders SM; Department of Medicine, University of Medicine and Dentistry of; New Jersey/Robert Wood Johnson Medical School at Camden, USA.
- The development of lipodystrophy as evidenced by central obesity, moon facies, and a buffalo hump is a classical feature of Cushing s disease. Recently an association of lipodystrophy with the use of protease inhibitors has been reported. We describe a patient
- Lichen nitidus and dinitrochlorabenzene [letter]
- J Am Acad Dermatol. 1999 Apr;40(4):647-8. Unique Identifier : AIDSLINE MED/99202580
- Stricker RB; Goldberg B
- Zidovudine-induced mitochondrial disorder with massive liver steatosis, myopathy, lactic acidosis, and mitochondrial DNA depletion.
- J Hepatol. 1999 Jan;30(1):156-60. Unique Identifier : AIDSLINE MED/99124353
- Chariot P; Drogou I; de Lacroix-Szmania I; Eliezer-Vanerot MC; Chazaud B; Lombes A; Schaeffer A; Zafrani ES; Department of Pathology, Hopital Henri Mondor, Groupe d'Etudes; et de Recherches sur le Muscle et le Nerf (EA 2347, Universite; Paris XII), Faculte de Medecine, Creteil, France.
- Zidovudine is known to be responsible for a mitochondrial myopathy with ragged-red fibres and mitochondrial DNA depletion in muscle. Lactic acidosis alone or associated with hepatic abnormalities has also been reported. A single report mentioned the concomitant occurrence of muscular and hepatic disturbances and lacti
- Risk factors for colonization or infection due to methicillin-resistant Staphylococcus aureus in HIV-positive patients: a retrospective case-control study.
- Unique Identifier : AIDSLINE MED/99124452
- Onorato M; Borucki MJ; Baillargeon G; Paar DP; Freeman DH; Cole CP
- Evaluation of the antimicrobial activity of a new super-oxidized water, Sterilox, for the disinfection of endoscopes.
- J Hosp Infect. 1999 Jan;41(1):59-70. Unique Identifier : AIDSLINE MED/99135125
- Selkon JB; Babb JR; Morris R; Department of Microbiology, George Eliot Hospital NHS Trust,; Nuneaton.
- The antimicrobial activity of a new super-oxidized water, Sterilox, has been tested against Mycobacterium tuberculosis, Mycobacterium avium-intracellulare, Mycobacterium chelonae, Escherichia coli (including type 0157), Enterococcus faecalis, Pseudomonas aeruginosa, Bacillus subtilis var niger spores, methicillin-resi
- IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells.
- J Immunol. 1999 Feb 1;162(3):1246-51. Unique Identifier : AIDSLINE MED/99138799
- Aarvak T; Chabaud M; Miossec P; Natvig JB; Institute of Immunology, Laboratory of Rheumatology Research, The; National Hospital, Oslo, Norway. tanja.aarvak@labmed.uio.no
- IL-17 is defined as a proinflammatory cytokine and produced by activated CD4+ T cells. In rheumatoid arthritis synovial tissue, high levels of IL-17 contribute to IL-6 production by synoviocytes. The present study was performed to see whether Th cells that produce IL-17 are associated with the Th1, Th2, or Th0 subset.
- IL-4 selectively inhibits IL-2-triggered Stat5 activation, but not proliferation, in human T cells.
- J Immunol. 1999 Feb 1;162(3):1261-9. Unique Identifier : AIDSLINE MED/99138801
- Castro A; Sengupta TK; Ruiz DC; Yang E; Ivashkiv LB; Department of Medicine, Hospital for Special Surgery, Cornell; University Medical College, New York, NY 10021, USA.
- IL-2 activates several distinct signaling pathways that are important for T cell activation, proliferation, and differentiation into both Th1 and Th2 phenotypes. IL-4, the major cytokine that promotes differentiation of Th2 cells, has been shown to block signaling of t
- Selective expression of a novel surface molecule by human Th2 cells in vivo.
- Unique Identifier : AIDSLINE MED/99138803
- Nagata K; Tanaka K; Ogawa K; Kemmotsu K; Imai T; Yoshie O; Abe H; Tada K; Nakamura M; Sugamura K; Takano S
- The search for reliable marker molecules discriminating between human Th1 and Th2 cells identified a gene encoding a novel member of the G protein-coupled leukocyte chemoattractant receptor
- Processing and release of IL-16 from CD4+ but not CD8+ T cells is activation dependent.
- J Immunol. 1999 Feb 1;162(3):1287-93. Unique Identifier : AIDSLINE MED/99138804
- Wu DM; Zhang Y; Parada NA; Kornfeld H; Nicoll J; Center DM; Cruikshank WW; Pulmonary Center, Boston University School of Medicine, Boston,; MA 02118, USA.
- IL-16 is synthesized as a precursor molecule of 68 kDa (pro-IL-16) that is processed by caspase-3, a member of the IL-1 converting enzyme (ICE) family. This cleavage results in a 13-kDa carboxy terminal peptide, which constitutes the bioactive secreted form of IL-16. We have previously reported constitutive IL-16 mRNA
- Processing of HIV-1 envelope glycoprotein for class I-restricted recognition: dependence on TAP1/2 and mechanisms for cytosolic localization.
- J Immunol. 1999 Feb 1;162(3):1324-32. Unique Identifier : AIDSLINE MED/99138809
- Ferris RL; Hall C; Sipsas NV; Safrit JT; Trocha A; Koup RA; Johnson RP; Siliciano RF; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, MD 21205, USA.
- Processing of viral proteins for recognition by CTL involves degradation of the proteins in the cytosol of an infected cell followed by transport of the resulting peptides into the endoplasmic reticulum (ER) by the TAP1/2 complex. Uncertainty exists over the site of processing of viral envelope (env) proteins since th
- Lymphotoxin alphabeta is expressed on recently activated naive and Th1-like CD4 cells but is down-regulated by IL-4 during Th2 differentiation.
- J Immunol. 1999 Feb 1;162(3):1333-8. Unique Identifier : AIDSLINE MED/99138810
- Gramaglia I; Mauri DN; Miner KT; Ware CF; Croft M; Divisions ofImmunochemistry and Molecular Immunology, La Jolla; Institute for Allergy and Immunology, San Diego, CA 92121, USA.
- Lymphotoxin (LT) is a cytokine that orchestrates lymphoid neogenesis and formation of germinal center reactions. LT exists as a membrane heterotrimer of alpha and beta subunits and is secreted as a homotrimer, LTalpha3. Using LTbetaR.Fc, expression of LTalphabeta on CD4 T cell subsets was investigated in a TCR transge
- TCR, LFA-1, and CD28 play unique and complementary roles in signaling T cell cytoskeletal reorganization.
- J Immunol. 1999 Feb 1;162(3):1367-75. Unique Identifier : AIDSLINE MED/99138814
- Sedwick CE; Morgan MM; Jusino L; Cannon JL; Miller J; Burkhardt JK; Department of Pharmacology and Physiology, University of Chicago,; Chicago, IL 60637, USA.
- T cells interacting with APCs undergo rearrangement of surface receptors and cytoskeletal elements to face the zone of contact with the APC. This polarization process is thought to affect T cell signaling by organizing a specialized domain on the T cell surface and to direct T cell effector function toward the appropr
- CD40-CD154 interaction and IFN-gamma are required for IL-12 but not prostaglandin E2 secretion by microglia during antigen presentation to Th1 cells.
- Unique Identifier : AIDSLINE MED/99138816
- Aloisi F; Penna G; Polazzi E; Minghetti L; Adorini L; Laboratory of Organ and System Pathophysiology, Istituto; Superiore di Sanita, Rome, Italy.
- IL-12 and PGE2 promote and inhibit, respectively, the development of Th1 responses. Production of these mediators by APC residing in the central nervous system (CNS) may be involved in the local regulation of the T cell phenotype during infectious and autoimmune CNS diseases. In the present study we have examined IL-1
- cAMP up-regulates cell surface expression of lymphocyte CXCR4: implications for chemotaxis and HIV-1 infection.
- Unique Identifier : AIDSLINE MED/99138817
- Cole SW; Jamieson BD; Zack JA; UCLA AIDS Institute, Department of Medicine, University of; California at Los Angeles School of Medicine, Los Angeles, CA; 90095, USA. coles@nicco.sscnet.ucla.edu
- The chemokine receptor CXCR4 mediates lymphocyte chemotaxis in response to stromal cell-derived factor-1 (SDF-1) and functions as a coreceptor for T cell-tropic strains of HIV-1. We examined the role of the cAMP-protein kinase A (PKA) signaling pathway in regulating expression of CXCR4. In response to exogenous dibuty
- AIDS primary central nervous system lymphoma: molecular analysis of the expressed VH genes and possible implications for lymphomagenesis.
- J Immunol. 1999 Feb 1;162(3):1551-8. Unique Identifier : AIDSLINE MED/99138835
- Julien S; Radosavljevic M; Labouret N; Camilleri-Broet S; Davi F; Raphael M; Martin T; Pasquali JL; Laboratoire d'Immunopathologie, Centre de Recherche; d'Immunohematologie, Hopital Civil, Hopitaux Universitaires,; Strasbourg, France.
- AIDS-associated primary central nervous system lymphomas are late events that have an extremely poor prognosis. Despite different hypotheses, the brain localization of these B cell lymphomas remains an enigma. To better define the cell origin of the lymphomas and the possible role of the B cell receptor (BCR) in the b
- In vivo IL-12 production and IL-12 receptors beta1 and beta2 mRNA expression in the spleen are differentially up-regulated in resistant B6 and susceptible A/J mice during early blood-stage Plasmodium chabaudi AS malaria.
- J Immunol. 1999 Feb 1;162(3):1582-9. Unique Identifier : AIDSLINE MED/99138839
- Sam H; Stevenson MM; McGill University Centre for the Study of Host Resistance, and; Montreal General Hospital Research Institute, Montreal, Quebec,; Canada.
- As previously reported, blood-stage Plasmodium chabaudi AS malaria is lethal by days 10-12 postinfection in susceptible A/J mice that mount an early, predominantly Th2 response. In contrast, resistant C57BL/6 (B6) mice clear the infection by 4 wk with an early Th1 response. In this study, we analyzed in vivo productio
- Mucosal DNA vaccine immunization against measles with a highly attenuated Shigella flexneri vector.
- J Immunol. 1999 Feb 1;162(3):1603-10. Unique Identifier : AIDSLINE MED/99138842
- Fennelly GJ; Khan SA; Abadi MA; Wild TF; Bloom BR; Department of Pediatrics, Howard Hughes Medical Institute, Albert; Einstein College of Medicine, Bronx, NY 10461, USA.; fennelly@aecom.yu.edu
- An intranasal vaccine vector would elicit protective immunity at the respiratory mucosa, the portal of entry and the primary site for replication for measles virus (MV) and other respiratory viruses. In a murine model of pulmonary Shigella, we demonstrate here that a candidate-attenuated Shigella vaccine vector is saf
- CpG oligodeoxynucleotides can circumvent the Th2 polarization of neonatal responses to vaccines but may fail to fully redirect Th2 responses established by neonatal priming.
- J Immunol. 1999 Feb 1;162(3):1611-7. Unique Identifier : AIDSLINE MED/99138843
- Kovarik J; Bozzotti P; Love-Homan L; Pihlgren M; Davis HL; Lambert PH; Krieg AM; Siegrist CA; World Health Organization Collaborating Centre for Neonatal; Vaccinology, University of Geneva, Geneva, Switzerland.; jiri.kovarik@medecine.unige.ch
- Neonatal murine responses to a panel of conventional vaccines differ qualitatively from adult responses by a particular polarization toward a Th2 pattern and a frequent limitation of the Th1 and CTL responses required for protection against intracellular microorganisms. In contrast, DNA vaccines induce adult-like Th1/
- Direct analysis of viral-specific CD8+ T cells with soluble HLA-A2/Tax11-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy.
- J Immunol. 1999 Feb 1;162(3):1765-71. Unique Identifier : AIDSLINE MED/99138863
- Bieganowska K; Hollsberg P; Buckle GJ; Lim DG; Greten TF; Schneck J; Altman JD; Jacobson S; Ledis SL; Hanchard B; Chin J; Morgan O; Roth PA; Hafler DA; Center for Neurologic Diseases, Brigham and Women's Hospital and; Harvard Medical School, Boston, MA 02115, USA.
- Human T cell lymphotropic virus-I (HTLV-I)-associated myelopathy is a slowly progressive neurologic disease characterized by inflammatory infiltrates in the central nervous system accompanied by clonal expansion of HTLV-I-reactive CD8+ T-cells. In patients carrying the HLA-A2 allele, the immune response is primarily d
- Frequency of class I HLA-restricted anti-HIV CD8+ T cells in individuals receiving highly active antiretroviral therapy (HAART).
- J Immunol. 1999 Feb 1;162(3):1780-8. Unique Identifier : AIDSLINE MED/99138865
- Gray CM; Lawrence J; Schapiro JM; Altman JD; Winters MA; Crompton M; Loi M; Kundu SK; Davis MM; Merigan TC; Center for AIDS Research, Division of Infectious Diseases and; Geographic Medicine, Stanford University Medical Center,; Stanford, CA 94305, USA.c.gray@niv.ac.za
- Peptide/MHC tetrameric complexes were used to enumerate the frequency of HLA class I-restricted epitope-specific CD8+ T cells in 18 HLA-A*0201 HIV type 1-infected asymptomatic patients. HLA-A*0201 molecules were complexed to HIV Gag p17 (amino acids 77-85) and reverse transcriptase (amino acids 464-472) peptides, biot
- A re-evaluation of the frequency of CD8+ T cells specific for EBV in healthy virus carriers.
- J Immunol. 1999 Feb 1;162(3):1827-35. Unique Identifier : AIDSLINE MED/99138871
- Tan LC; Gudgeon N; Annels NE; Hansasuta P; O'Callaghan CA; Rowland-Jones S; McMichael AJ; Rickinson AB; Callan MF; Molecular Immunology Group, Institute of Molecular Medicine, John; Radcliffe Hospital, Oxford, United Kingdom.
- EBV is a gammaherpesvirus that can establish both nonproductive (latent) and productive (lytic) infections within the cells of its host. Although T cell responses to EBV latent proteins have been well characterized, little is known about the importance of responses to lytic proteins in long term virus carriers. Here w
- An altered peptide ligand specifically inhibits Th2 cytokine synthesis by abrogating TCR signaling.
- J Immunol. 1999 Feb 1;162(3):1836-42. Unique Identifier : AIDSLINE MED/99138872
- Faith A; Akdis CA; Akdis M; Joss A; Wymann D; Blaser K; Swiss Institute of Allergy and Asthma Research, Davos,; Switzerland. siaf@siaf.unizh.ch
- Altered peptide ligands (APL) can modify T cell effector function by their diversity in binding to the TCR or MHC class II-presenting molecules. The capacity to inhibit Th2 cytokine production by allergen-specific T cells would contribute to combating allergic inflammation. The presence of APL generated by Ala-substit
- Mucosally induced systemic T cell unresponsiveness to ovalbumin requires CD40 ligand-CD40 interactions.
- J Immunol. 1999 Feb 15;162(4):1904-9. Unique Identifier : AIDSLINE MED/99138880
- Kweon MN; Fujihashi K; Wakatsuki Y; Koga T; Yamamoto M; McGhee JR; Kiyono H; Department of Oral Biology, Immunobiology Vaccine Center,; University of Alabama Medical Center, Birmingham 35294, USA.
- CD40 ligand (CD40L) gene-disrupted (CD40L-/-) mice were employed to examine the role of costimulatory signals via CD40L-CD40 interactions in mucosally induced tolerance. CD40L-/- and control (CD40L+/+) mice of the same C57BL/6 x 129/J background were immunized orally with 25 mg of OVA before systemic challenge with OV
- TCR-independent pathways mediate the effects of antigen dose and altered peptide ligands on Th cell polarization.
- J Immunol. 1999 Feb 15;162(4):1923-30. Unique Identifier : AIDSLINE MED/99138883
- Grakoui A; Donermeyer DL; Kanagawa O; Murphy KM; Allen PM; Center for Immunology and Department of Pathology, Washington; University School of Medicine, St. Louis, MO 63110, USA.
- We examined the role of the peptide/MHC ligand in CD4+ T cell differentiation into Th1 or Th2 cells using a TCR alphabeta transgenic mouse specific for hemoglobin (Hb)(64-76)/I-Ek. We identified two altered peptide ligands of Hb(64-76) that retain strong agonist activity but, at a given dose, induce cytokine patterns
- Evidence of positive cross-regulation on Th1 by Th2 and antigen-presenting cells: effects on Th1 induced by IL-4 and IL-12.
- J Immunol. 1999 Feb 15;162(4):1999-2007. Unique Identifier : AIDSLINE MED/99138894
- Oriss TB; McCarthy SA; Campana MA; Morel PA; University of Pittsburgh Cancer Institute, Department of; Medicine, PA 15213, USA.
- The response of Th cells to cytokines is normally strictly regulated, such that following antigenic stimulation, Th cells respond for only a short period of time, after which they become refractory to cytokine-mediated effects. IL-12, a costimulator of Th1 having no proliferation-inducing capacity of its own, allows T
- CD40 activation boosts T cell immunity in vivo by enhancing T cell clonal expansion and delaying peripheral T cell deletion.
- J Immunol. 1999 Feb 15;162(4):2024-34. Unique Identifier : AIDSLINE MED/99138897
- Maxwell JR; Campbell JD; Kim CH; Vella AT; Department of Microbiology, Oregon State University, Corvallis; 97331, USA.
- In this report we show that activation of APC with an agonist anti-CD40 mAb profoundly alters the behavior of CD4 T cells in vivo. Stimulation of mice with anti-CD40 2 days before, but not 1 day after, administration of superantigen (SAg) enhanced CD4 and CD8 T cell clonal expansion by approximately threefold. Further
- Serial TCR engagement and down-modulation by peptide:MHC molecule ligands: relationship to the quality of individual TCR signaling events.
- J Immunol. 1999 Feb 15;162(4):2073-80. Unique Identifier : AIDSLINE MED/99138903
- Itoh Y; Hemmer B; Martin R; Germain RN; Lymphocyte Biology Section, Laboratory of Immunology, National; Institute of Allergy and Infectious Diseases, Bethesda, MD 20892,; USA.
- In the present study, we examined the relationships among quantitative aspects of TCR engagement as measured by receptor down-modulation, functional responses, and biochemical signaling events using both mouse and human T cell clones. For T cells from both species, ligands that are more potent in inducing functional r
- Mycobacterium bovis bacille Calmette-Guerin enhances pathogenicity of simian immunodeficiency virus infection and accelerates progression to AIDS in macaques: a role of persistent T cell activation in AIDS pathogenesis.
- Unique Identifier : AIDSLINE MED/99138919
- Zhou D; Shen Y; Chalifoux L; Lee-Parritz D; Simon M; Sehgal PK; Zheng L; Halloran M; Chen ZW
- It has recently been proposed that Mycobacterium tuberculosis may enhance the pathogenicity of HIV infections and accelerate the course of HIV disease. This hypothesis has been tested in the present study using a simian immunodeficiency virus of macaques (SIVmac)/Mycobacterium bovis bacille Calmette-Guerin (BCG)-coinf
- IL-12 administered during Chlamydia psittaci lung infection in mice confers immediate and long-term protection and reduces macrophage inflammatory protein-2 level and neutrophil infiltration in lung tissue.
- J Immunol. 1999 Feb 15;162(4):2217-26. Unique Identifier : AIDSLINE MED/99138920
- Huang J; Wang MD; Lenz S; Gao D; Kaltenboeck B; Department of Pathobiology, College of Veterinary Medicine,; Auburn University, AL 36849, USA.
- Protection against infections with the intracellular bacterium Chlamydia spp. requires Th1-polarized CD4+ T cell immunity. In BALB/c mouse lung infections, immediate innate and nascent Chlamydia-specific immune responses following intranasal inoculation of Chlamydia psittaci strain B577 were modulated by 7-day i.p. ad
- Conserved CTL epitopes shared between HIV-infected human long-term survivors and chimpanzees.
- J Immunol. 1999 Feb 15;162(4):2308-14. Unique Identifier : AIDSLINE MED/99138931
- Balla-Jhagjhoorsingh SS; Koopman G; Mooij P; Haaksma TG; Teeuwsen VJ; Bontrop RE; Heeney JL; Department of Virology, Biomedical Primate Research Centre,; Rijswijk, The Netherlands.
- Certain HIV-1 infected humans that do not progress to AIDS have been documented to share particular MHC class I alleles that appear to correlate with long-term survival. HIV-1-infected chimpanzees are relatively resistant to progression to AIDS. Out of a group of 10 chimpanzees with CTL activity and nonprogressive HIV
- CD95 (Fas/Apo-1) as a receptor governing astrocyte apoptotic or inflammatory responses: a key role in brain inflammation?
- J Immunol. 1999 Feb 15;162(4):2326-33. Unique Identifier : AIDSLINE MED/99138934
- Saas P; Boucraut J; Quiquerez AL; Schnuriger V; Perrin G; Desplat-Jego S; Bernard D; Walker PR; Dietrich PY; Laboratory of Tumor Immunology, Division of Oncology, University; Hospital, Geneva, Switzerland.
- Astrocytes are a major cellular component of the brain that are capable of intense proliferation and metabolic activity during diverse inflammatory brain diseases (such as multiple sclerosis, Alzheimer s dementia , tumor, HIV encephalitis, or prion disease). In this biological proce
- Modulation of airway inflammation by passive transfer of allergen-specific Th1 and Th2 cells in a mouse model of asthma.
- J Immunol. 1999 Feb 15;162(4):2375-83. Unique Identifier : AIDSLINE MED/99138941
- Randolph DA; Carruthers CJ; Szabo SJ; Murphy KM; Chaplin DD; Center for Immunology, Department of Internal Medicine,; Washington University School of Medicine, St. Louis, MO 63110,; USA.
- Although evidence is strong that Th cells play a major role in mediating the airway inflammation observed in asthma, the relative contributions of the Th cell subsets, Th1 and Th2, are unclear. It has been suggested that asthma is driven by Th2 predominant responses in the lung, but other data suggest a role for Th1 c
- IFN-alpha 2B enhances Th1 cytokine responses in bladder cancer patients receiving Mycobacterium bovis bacillus Calmette-Guerin immunotherapy.
- J Immunol. 1999 Feb 15;162(4):2399-405. Unique Identifier : AIDSLINE MED/99138944
- Luo Y; Chen X; Downs TM; DeWolf WC; O'Donnell MA; Division of Urology, Beth Israel Deaconess Medical Center,; Harvard Medical School, Boston, MA 02215, USA.
- Combination therapy with intravesical bacillus Calmette-Guerin (BCG) plus IFN-alpha for superficial bladder cancer has been demonstrated to be more effective than either single agent alone in animal studies and of suggested greater efficacy in clinical studies. However, the mechanism by which IFN-alpha enhances BCG-me
- Extracellular HIV-1 tat protein up-regulates the expression of surface CXC-chemokine receptor 4 in resting CD4+ T cells.
- J Immunol. 1999 Feb 15;162(4):2427-31. Unique Identifier : AIDSLINE MED/99138948
- Secchiero P; Zella D; Capitani S; Gallo RC; Zauli G; Institute of Human Virology, University of Maryland Biotechnology; Institute, Baltimore 21201, USA. secchier@umbi.umd.edu
- Here we report that synthetic HIV-1 Tat protein, immobilized on a solid substrate, up-regulates the surface expression of the CXC-chemokine receptor 4 (CXCR4), but not of the CC-chemokine receptor 5 in purified populations of primary resting CD4+ T cells. The Tat-mediated increase of CXCR4 occurred in a well-defined r
- Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells.
- J Immunol. 1999 Mar 1;162(5):2477-87. Unique Identifier : AIDSLINE MED/99172175
- Li L; Xia Y; Nguyen A; Lai YH; Feng L; Mosmann TR; Lo D; Department of Immunology IMM-25, Scripps Research Institute, La; Jolla, CA 92037, USA.
- Airway inflammation associated with asthma is characterized by massive infiltration of eosinophils, mediated in part by specific chemoattractant factors produced in the lung. Allergen-specific Th2 cells appear to play a central role in asthma; for example, adoptively transferred Th2 cells induced lung eosinophilia ass
- Tolerance to antigen-presenting cell-depleted islet allografts is CD4 T cell dependent.
- J Immunol. 1999 Mar 1;162(5):2503-10. Unique Identifier : AIDSLINE MED/99172178
- Coulombe M; Yang H; Wolf LA; Gill RG; Barbara Davis Center for Childhood Diabetes/University of; Colorado Health Sciences Center, Denver, CO 80262, USA.
- Pretreatment of pancreatic islets in 95% oxygen culture depletes graft-associated APCs and leads to indefinite allograft acceptance in immunocompetent recipients. As such, the APC-depleted allograft represents a model of peripheral alloantigen presentation in the absence of donor-derived costimulation. Over time, a st
- Islet-specific Th1, but not Th2, cells secrete multiple chemokines and promote rapid induction of autoimmune diabetes.
- J Immunol. 1999 Mar 1;162(5):2511-20. Unique Identifier : AIDSLINE MED/99172179
- Bradley LM; Asensio VC; Schioetz LK; Harbertson J; Krahl T; Patstone G; Woolf N; Campbell IL; Sarvetnick N; Departments ofImmunology and Neuropharmacology, The Scripps; Research Institute, La Jolla, CA 92037, USA. lbradley@scripps.edu
- Migration of CD4 cells into the pancreas represents a hallmark event in the development of insulin-dependent diabetes mellitus. Th1, but not Th2, cells are associated with pathogenesis leading to destruction of islet beta-cells and disease onset. Lymphocyte extravasation from blood into tissue is regulated by multiple
- IL-15 induces the expression of chemokines and their receptors in T lymphocytes.
- J Immunol. 1999 Mar 1;162(5):2606-12. Unique Identifier : AIDSLINE MED/99172191
- Perera LP; Goldman CK; Waldmann TA; Metabolism Branch, Division of Clinical Sciences, National Cancer; Institute, Bethesda, MD 20892, USA. lperera@atlas.niaid.nih.gov
- IL-15 is a T cell growth factor that shares many biological activities with IL-2 and uses the same beta/gamma polypeptides of the IL-2R complex for signal transduction. Accumulating evidence implicates an important role for this cytokine in the inflammatory response of
- Potent inhibition of CD4/TCR-mediated T cell apoptosis by a CD4-binding glycoprotein secreted from breast tumor and seminal vesicle cells.
- J Immunol. 1999 Mar 1;162(5):2631-8. Unique Identifier : AIDSLINE MED/99172194
- Gaubin M; Autiero M; Basmaciogullari S; Metivier D; Mis hal Z; Culerrier R; Oudin A; Guardiola J; Piatier-Tonneau D; Genetique Moleculaire et de Biologie du Developpement, Unite; Propre de Recherche 420, Centre National de la Recherche; Scientifique, Villejuif, France.
- We previously isolated a CD4 ligand glycoprotein, gp17, from human seminal plasma; this glycoprotein is identical with gross cystic disease fluid protein-15 (GCDFP-15), a factor specifically secreted from primary and secondary breast tumors. The function of gp17/GCDFP-15 in physiological as well as in pathological con
- Enhanced cytotoxic T cell activity in IL-4-deficient mice.
- J Immunol. 1999 Mar 1;162(5):2663-70. Unique Identifier : AIDSLINE MED/99172198
- Villacres MC; Bergmann CC; Departments ofNeurology and Microbiology and Molecular; Immunology, University of Southern California School of Medicine,; Los Angeles, CA 90033, USA.
- CD8+ effectors are critical components of type 1 responses against viral infections as well as for antiviral vaccines. IL-4 plays a clear role as an inhibitor of CD4+ Th1 cells; however, its role in CD8+ T cell regulation appears to be more complex. Thus, IL-4 may augment CD8+ T cell growth, but also limit effector fu
- Soluble class I MHC with beta2-microglobulin covalently linked peptides: specific binding to a T cell hybridoma.
- J Immunol. 1999 Mar 1;162(5):2671-6. Unique Identifier : AIDSLINE MED/99172199
- White J; Crawford F; Fremont D; Marrack P; Kappler J; Division of Basic Immunology, Howard Hughes Medical Institute,; National Jewish Medical and Research Center, Denver, CO 80206,; USA.
- Soluble forms of the mouse MHC class I molecule, Dd, were produced in which the peptide binding groove was uniformly occupied by peptides attached via a covalent flexible peptide linker to the N terminus of the associated beta2-microglobulin. The MHC heavy chain and beta2-microglobulin were firmly associated, and the
- Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice.
- J Immunol. 1999 Mar 1;162(5):2829-36. Unique Identifier : AIDSLINE MED/99172219
- Rottenberg ME; Gigliotti Rothfuchs AC; Gigliotti D; Svanholm C; Bandholtz L; Wigzell H; Microbiology and Tumorbiology Center, Karolinska Institute,; Stockholm, Sweden. martin.rottenberg@mtc.ki.se
- Infection with Chlamydia pneumoniae is a common cause of acute respiratory disease in man and is also associated with atherosclerotic cardiovascular disorder. Herein, we have compared bacterial load and immune parameters of C. pneumoniae-infected mice genomically lacking T cell coreceptors, cytokine receptors, or cyto
- Cancer dormancy. VII. A regulatory role for CD8+ T cells and IFN-gamma in establishing and maintaining the tumor-dormant state.
- Unique Identifier : AIDSLINE MED/99172221
- Farrar JD; Katz KH; Windsor J; Thrush G; Scheuermann RH; Uhr JW; Street NE
- Dormant tumor cells resistant to ablative cancer therapy represent a significant clinical obstacle due to later relapse. Experimentally, the murine B cell lymphoma (BCL1) is used as a model of tumor dormancy in mice vaccinated with the BCL1 Ig. Here, we used this model to explore the cellular mechanisms underlying dor
- Control of syngeneic tumor growth by activation of CD8+ T cells: efficacy is limited by migration away from the site and induction of nonresponsiveness.
- J Immunol. 1999 Mar 1;162(5):2858-66. Unique Identifier : AIDSLINE MED/99172223
- Shrikant P; Mescher MF; Center for Immunology, University of Minnesota, Minneapolis, MN; 55455, USA.
- Activation of Ag-specific CD8+ T cells in response to syngeneic tumor has been visualized by adoptive transfer of CD8+ T cells from OT-I mice, with a transgenic TCR specific for H-2Kb and an OVA peptide, into Thy-1 congenic recipients. Intraperitoneal challenge with E.G7, the EL-4 thymoma transfected with OVA, results
- Experimental murine schistosomiasis in the absence of B7 costimulatory molecules: reversal of elicited T cell cytokine profile and partial inhibition of egg granuloma formation.
- J Immunol. 1999 Mar 1;162(5):2884-9. Unique Identifier : AIDSLINE MED/99172226
- Hernandez HJ; Sharpe AH; Stadecker MJ; Department of Pathology, Tufts University School of Medicine,; Boston, MA 02111, USA.
- The granulomatous inflammation in infection with the helminth Schistosoma mansoni represents a cellular hypersensitivity reaction mediated by, and dependent upon, MHC class II-restricted CD4+ Th cells sensitized to parasite egg Ags. The current work examines the role and significance of the B7:CD28/CTLA-4 pathway in p
- IFN-gamma and CD8+ T cells restore host defenses against Pneumocystis carinii in mice depleted of CD4+ T cells.
- J Immunol. 1999 Mar 1;162(5):2890-4. Unique Identifier : AIDSLINE MED/99172227
- Kolls JK; Habetz S; Shean MK; Vazquez C; Brown JA; Lei D; Schwarzenberger P; Ye P; Nelson S; Summer WR; Shellito JE; Section of Pulmonary/Critical Care, Gene Therapy Program, and; Section of Hematology/Oncology, Louisiana State University; Medical Center School of Medicine, New Orleans, LA 70112, USA.; jkolls@lsumc.edu
- Host defenses against infection are profoundly compromised in HIV-infected hosts due to progressive depletion of CD4+ T lymphocytes and defective cell-mediated immunity. Although recent advances in antiretroviral therapy can dramatically lower HIV viral load, blood CD4+ T lymphocytes are not restored to normal levels.
- IL-12 gene as a DNA vaccine adjuvant in a herpes mouse model: IL-12 enhances Th1-type CD4+ T cell-mediated protective immunity against herpes simplex virus-2 challenge.
- J Immunol. 1999 Mar 1;162(5):2912-21. Unique Identifier : AIDSLINE MED/99172230
- Sin JI; Kim JJ; Arnold RL; Shroff KE; McCallus D; Pachuk C; McElhiney SP; Wolf MW; Pompa-de Bruin SJ; Higgins TJ; Ciccarelli RB; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
- IL-12 has been shown to enhance cellular immunity in vitro and in vivo. Recent reports have suggested that combining DNA vaccine approach with immune stimulatory molecules delivered as genes may significantly enhance Ag-specific immune responses in vivo. In particular, IL-12 molecules could constitute an important add
- The human T cell leukemia virus type I-tax gene is responsible for the development of both inflammatory polyarthropathy resembling rheumatoid arthritis and noninflammatory ankylotic arthropathy in transgenic mice.
- J Immunol. 1999 Mar 1;162(5):2956-63. Unique Identifier : AIDSLINE MED/99172235
- Habu K; Nakayama-Yamada J; Asano M; Saijo S; Itagaki K; Horai R; Yamamoto H; Sekiguchi T; Nosaka T; Hatanaka M; Iwakura Y; Center for Experimental Medicine, Institute of Medical Science,; University of Tokyo, Minato-ku, Tokyo, Japan.
- We previously reported that inflammatory arthropathy resembling rheumatoid arthritis (RA) develops among transgenic mice carrying the long terminal repeat (LTR)-env-pX-LTR region of human T cell leukemia virus type I (LTR-pX-Tg mice). Because four genes are encoded in this region, we produced transgenic mice that only
- HIV-1-specific CTL responses primed in vitro by blood-derived dendritic cells and Th1-biasing cytokines.
- J Immunol. 1999 Mar 1;162(5):3070-8. Unique Identifier : AIDSLINE MED/99172249
- Wilson CC; Olson WC; Tuting T; Rinaldo CR; Lotze MT; Storkus WJ; Departments ofInternal Medicine, Surgery, Infectious Diseases and; Microbiology, University of Pittsburgh School of Medicine,; Pennsylvania, USA.
- Vaccine strategies designed to elicit strong cell-mediated immune responses to HIV Ags are likely to lead to protective immunity against HIV infection. Dendritic cells (DC) are the most potent APCs capable of priming both MHC class I- and II-restricted, Ag-specific T cell responses. Utilizing a system in which culture
- Negative selection of immature thymocytes by a few peptide-MHC complexes: differential sensitivity of immature and mature T cells.
- J Immunol. 1999 Mar 15;162(6):3117-20. Unique Identifier : AIDSLINE MED/99192719
- Peterson DA; DiPaolo RJ; Kanagawa O; Unanue ER; Center for Immunology, Washington University School of Medicine,; St. Louis, MO 63110, USA.
- We quantitated the number of peptide-class II MHC complexes required to affect the deletion or activation of 3A9 TCR transgenic thymocytes. Deletion of immature double positive thymocytes was very sensitive, taking place with approximately three peptide-MHC complexes per APC. However, the activation of mature CD4+ thy
- Chronic modulation of the TCR repertoire in the lymphoid periphery.
- J Immunol. 1999 Mar 15;162(6):3131-40. Unique Identifier : AIDSLINE MED/99192722
- Blish CA; Gallay BJ; Turk GL; Kline KM; Wheat W; Fink PJ; Department of Immunology, School of Medicine, University of; Washington, Seattle 98195, USA.
- Using TCR V beta 5 transgenic mice as a model system, we demonstrate that the induction of peripheral tolerance can mold the TCR repertoire throughout adult life. In these mice, three distinct populations of peripheral T cells are affected by chronic selective events in the lymphoid periphery. First, CD4+V beta 5+ T c
- Reciprocal expression in CD4 or CD8 subsets of different members of the V alpha 11 gene family correlates with sequence polymorphism.
- J Immunol. 1999 Mar 15;162(6):3153-9. Unique Identifier : AIDSLINE MED/99192725
- Sim BC; Gascoigne NR; Department of Immunology, Scripps Research Institute, La Jolla,; CA 92037, USA.
- Previous staining studies with TCR V alpha 11-specific mAbs showed that V alpha 11.1/11.2 (AV11S1 and S2) expression was selectively favored in the CD4+ peripheral T cell population. As this phenomenon was essentially independent of the MHC haplotype, it was suggested that AV11S1 and S2 TCRs exert a preference for rec
- Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4.
- J Immunol. 1999 Mar 15;162(6):3193-201. Unique Identifier : AIDSLINE MED/99192730
- Lim YC; Henault L; Wagers AJ; Kansas GS; Luscinskas FW; Lichtman AH; Department of Pathology, Brigham and Women's Hospital, Boston, MA; 02115-5814, USA.
- Immune responses may be qualitatively distinct depending on whether Th1 or Th2 cells predominate at the site of Ag exposure. T cell subset-specific expression of ligands for vascular selectins may underlie the distinct patterns of recruitment of Th1 or Th2 cells to peripheral inflammatory sites. Here we examine the re
- Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells.
- J Immunol. 1999 Mar 15;162(6):3256-62. Unique Identifier : AIDSLINE MED/99192737
- Curtsinger JM; Schmidt CS; Mondino A; Lins DC; Kedl RM; Jenkins MK; Mescher MF; Center for Immunology, University of Minnesota, Minneapolis; 55455, USA.
- The effects of inflammatory cytokines on naive T cells have been studied using MHC protein/peptide complexes on microspheres, thus avoiding the use of APCs whose functions may be affected by the cytokines. IL-1, but not IL-12, increased proliferation of CD4+ T cells in response to Ag and
- Fas-mediated suicide of tumor-reactive T cells following activation by specific tumor: selective rescue by caspase inhibition.
- J Immunol. 1999 Mar 15;162(6):3273-9. Unique Identifier : AIDSLINE MED/99192739
- Zaks TZ; Chappell DB; Rosenberg SA; Restifo NP; Surgery Branch, National Cancer Institute, Bethesda, MD 20892,; USA. zakst@nih.gov
- CD8+ T lymphocytes that specifically recognize tumor cells can be isolated and expanded ex vivo. While the lytic properties of these cells have been well described, their fate upon encounter with cognate tumor is not known. We performed reverse 51Cr release assays in which the lymphocyte effectors rather than the tumo
- Postthymic development of CD28-CD8+ T cell subset: age-associated expansion and shift from memory to naive phenotype.
- J Immunol. 1999 Mar 15;162(6):3327-35. Unique Identifier : AIDSLINE MED/99192746
- Nociari MM; Telford W; Russo C; Laboratory of Immunology, Cornell University Medical College, New; York 10021, USA.
- During human aging, one of the major changes in the T cell repertoire is a dramatic expansion of T cells with the atypical CD28-CD8+ phenotype. In this study, we show that this increase is a consequence not only of an expansion in the CD28-CD8+ population but also of a decrease in the number of CD28+CD8+ T cells. The
- Suppressive immunization with DNA encoding a self-peptide prevents autoimmune disease: modulation of T cell costimulation.
- J Immunol. 1999 Mar 15;162(6):3336-41. Unique Identifier : AIDSLINE MED/99192747
- Ruiz PJ; Garren H; Ruiz IU; Hirschberg DL; Nguyen LV; Karpuj MV; Cooper MT; Mitchell DJ; Fathman CG; Steinman L; Department of Neurology and Neurological Sciences, Beckman Center; for Molecular Medicine, Stanford University, CA 94305, USA.
- Usually we rely on vaccination to promote an immune response to a pathogenic microbe. In this study, we demonstrate a suppressive from of vaccination, with DNA encoding a minigene for residues 139-151 of myelin proteolipid protein (PLP139-151), a pathogenic self-Ag. This suppressive vaccination attenuates a prototypic
- CD86 (B7-2) can function to drive MHC-restricted antigen-specific CTL responses in vivo.
- J Immunol. 1999 Mar 15;162(6):3417-27. Unique Identifier : AIDSLINE MED/99192757
- Agadjanyan MG; Kim JJ; Trivedi N; Wilson DM; Monzavi-Karbassi B; Morrison LD; Nottingham LK; Dentchev T; Tsai A; Dang K; Chalian AA; Maldonado MA; Williams WV; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104, USA.; agadjany@mail.med.upenn.edu
- Activation of T cells requires both TCR-specific ligation by direct contact with peptide Ag-MHC complexes and coligation of the B7 family of ligands through CD28/CTLA-4 on the T cell surface. We recently reported that coadministration of CD86 cDNA along with DNA encoding HIV-1 Ags i.m. dramatically increased Ag-specif
- The T cell-specific CXC chemokines IP-10, Mig, and I-TAC are expressed by activated human bronchial epithelial cells.
- J Immunol. 1999 Mar 15;162(6):3549-58. Unique Identifier : AIDSLINE MED/99192773
- Sauty A; Dziejman M; Taha RA; Iarossi AS; Neote K; Garcia-Zepeda EA; Hamid Q; Luster AD; Infectious Disease Unit, Massachusetts General Hospital,; Charlestown 02129, USA.
- Recruitment of activated T cells to mucosal surfaces, such as the airway epithelium, is important in host defense and for the development of inflammatory diseases at these sites. We therefore asked whether the CXC chemokines IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible
- Nasopharyngeal-associated lymphoreticular tissue (NALT) immunity: fimbriae-specific Th1 and Th2 cell-regulated IgA responses for the inhibition of bacterial attachment to epithelial cells and subsequent inflammatory cytokine production.
- J Immunol. 1999 Mar 15;162(6):3559-65. Unique Identifier : AIDSLINE MED/99192774
- Yanagita M; Hiroi T; Kitagaki N; Hamada S; Ito H; Shimauchi H; Murakami S; Okada H; Kiyono H; Department of Mucosal Immunology, Faculty of Dentistry, Osaka; University, Japan.
- To investigate the antibacterial activity of mucosal Th1 and Th2 immune responses induced nasally and orally, mice were immunized with mucosal vaccine containing fimbrial protein of Porphyromonas gingivalis, a causative agent for a destructive chronic inflammation in the periodontium, and cholera toxin (CT) as mucosal
- Implication of TNF receptor-I-mediated extracellular signal-regulated kinases 1 and 2 (ERK1/2) activation in growth of AIDS-associated Kaposi's sarcoma cells: a possible role of a novel death domain protein MADD in TNF-alpha-induced ERK1/2 activation in Kaposi's sarcoma cells.
- J Immunol. 1999 Mar 15;162(6):3672-9. Unique Identifier : AIDSLINE MED/99192789
- Murakami-Mori K; Mori S; Bonavida B; Nakamura S; Department of Microbiology and Immunology, University of; California, School of Medicine, Los Angeles 90095, USA.
- TNF-alpha is a key pathogenic mediator of infectious and inflammatory diseases. HIV infection stimulates and dysregulates the immune system, leading to abnormal production of TNF-alpha. Despite its cytotoxic effect on some tumor cell lines, TNF-alpha functions as a growth stimulator for Kaposi s sarcoma (KS), a common
- Clonal dominance patterns of CD8 T cells in relation to disease progression in HIV-infected children.
- J Immunol. 1999 Mar 15;162(6):3680-6. Unique Identifier : AIDSLINE MED/99192790
- Than S; Kharbanda M; Chitnis V; Bakshi S; Gregersen PK; Pahwa S; Department of Pediatrics, North Shore University Hospital, New; York University School of Medicine, Manhasset 11030, USA.
- CD8 T cells are important mediators of cellular immune responses as evidenced by clonal expansions in the CD8 TCR V beta repertoire during primary HIV infection in adults. This study investigated the CD8 TCR V beta repertoire by complementarity-determining region 3 length analysis using multiplex PCR in purified perip
- EBV gene expression not altered in rheumatoid synovia despite the presence of EBV antigen-specific T cell clones.
- J Immunol. 1999 Mar 15;162(6):3694-701. Unique Identifier : AIDSLINE MED/99192792
- Edinger JW; Bonneville M; Scotet E; Houssaint E; Schumacher HR; Posnett DN; Immunology Program, Graduate School of Medical Sciences, Weill; Medical College, Cornell University Weill, New York 10021, USA.
- T cells infiltrating the rheumatoid arthritis (RA) joint are oligoclonal, implicating an Ag-driven process, but the putative joint-specific Ags remain elusive. Here we examine expression of selected EBV genes in RA synovia and find no abnormal expression in RA. DNA of
- Colitis-inducing potency of CD4+ T cells in immunodeficient, adoptive hosts depends on their state of activation, IL-12 responsiveness, and CD45RB surface phenotype.
- J Immunol. 1999 Mar 15;162(6):3702-10. Unique Identifier : AIDSLINE MED/99192793
- Claesson MH; Bregenholt S; Bonhagen K; Thoma S; Moller P; Grusby MJ; Leithauser F; Nissen MH; Reimann J; Department of Medical Anatomy, University of Copenhagen, Denmark.; m.h.claesson@mai.ku.dk
- We studied the induction, severity and rate of progression of inflammatory bowel disease (IBD) induced in SCID mice by the adoptive transfer of low numbers of the following purified BALB/c CD4+ T cell subsets: 1) unfractionated, peripheral, small (resting), or large (activated) CD4+ T cells; 2) fractionated, periphera
- Differential effects of CD40 ligand/trimer stimulation on the ability of dendritic cells to replicate and transmit HIV infection: evidence for CC-chemokine-dependent and -independent mechanisms.
- J Immunol. 1999 Mar 15;162(6):3711-7. Unique Identifier : AIDSLINE MED/99192794
- McDyer JF; Dybul M; Goletz TJ; Kinter AL; Thomas EK; Berzofsky JA; Fauci AS; Seder RA; Clinical Immunology Section, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA.
- The role of exogenous stimulation of CD40 by CD40 ligand (CD40L) in dendritic cell (DC) maturation, CC-chemokine production, and CCR5 receptor expression was examined using a soluble trimeric CD40L agonist protein (CD40LT). Stimulation of monocyte-derived DCs with CD40LT enhanced the production of the CC-chemokines ma
- Kinetics of the changes of lymphocyte subsets defined by cytokine production at single cell level during highly active antiretroviral therapy for HIV-1 infection.
- J Immunol. 1999 Mar 15;162(6):3718-26. Unique Identifier : AIDSLINE MED/99192795
- Sousa AE; Chaves AF; Doroana M; Antunes F; Victorino RM; Cellular Immunology Unit, Faculty of Medicine of Libson,; Portugal.
- The effects of highly active antiretroviral therapy on cytokine imbalances associated with HIV-1 infection have not been characterized. Using single cell analysis by flow cytometry, we show that a significant recovery in the frequency of IL-2-producing cells was only observed in patients with a sustained control of vi
- Molecular and functional analysis of a conserved CTL epitope in HIV-1 p24 recognized from a long-term nonprogressor: constraints on immune escape associated with targeting a sequence essential for viral replication.
- J Immunol. 1999 Mar 15;162(6):3727-34. Unique Identifier : AIDSLINE MED/99192796
- Wagner R; Leschonsky B; Harrer E; Paulus C; Weber C; Walker BD; Buchbinder S; Wolf H; Kalden JR; Harrer T; Institute of Medical Microbiology, University of Regensburg,; Germany.
- It has been hypothesized that sequence variation within CTL epitopes leading to immune escape plays a role in the progression of HIV-1 infection. Only very limited data exist that address the influence of biologic characteristics of CTL epitopes on the emergence of immune escape variants and the efficiency of suppress
- Depletion of cutaneous peptidergic innervation in HIV-associated xerosis.
- J Invest Dermatol. 1999 Mar;112(3):284-9. Unique Identifier : AIDSLINE MED/99181794
- Rowe A; Mallon E; Rosenberger P; Barrett M; Walsh J; Bunker CB; Skin Treatment and Research Trust Laboratory, Imperial College; School of Medicine, Chelsea & Westminster Hospital, London, UK.
- Severe xerosis occurs in approximately 20% of human immunodeficiency virus seropositive patients. Changes in cutaneous innervation have been found in various inflammatory skin diseases and in xerotic skin in familial amyloid. We have therefore carried out a quantitative examination of the cutaneous peptidergic innerva
- In vivo expression and localization of Candida albicans secreted aspartyl proteinases during oral candidiasis in HIV-infected patients.
- J Invest Dermatol. 1999 Mar;112(3):383-6. Unique Identifier : AIDSLINE MED/99181810
- Schaller M; Hube B; Ollert MW; Schafer W; Borg-von Zepelin M; Thoma-Greber E; Korting HC; Department of Dermatology, Ludwig-Maximilians-University Munich,; Germany.
- Isoforms of aspartyl proteinase (Sap), which are encoded by at least nine related SAP genes, have been implicated to be a major virulence factor of the opportunistic yeast Candida albicans in experimental infections. Although it is generally assumed that proteinases are important for infections, detailed information o
- Human experimentation with Neisseria gonorrhoeae: progress and goals.
- Unique Identifier : AIDSLINE MED/99181351
- Cohen MS; Cannon JG
- Infection with Neisseria gonorrhoeae has adverse consequences for reproductive health and facilitates the transmission of the human immunodeficiency virus. A major limitation in the development of gonococcal vaccines has been the lack of an animal model. Urethral infection can be initiated in male volunteer subjects t
- Determinants of the natural history of human immunodeficiency virus type 1 infection.
- J Infect Dis. 1999 Mar;179 Suppl 2:S384-6. Unique Identifier : AIDSLINE MED/99181353
- Phair JP; Northwestern University Medical School, Comprehensive AIDS; Center, Chicago, Illinois 60611, USA.
- Variation in the time to AIDS and duration of survival of human immunodeficiency virus (HIV)-1-infected persons was recognized early in the epidemic. Recent studies have indicated that the rate of viral replication, as manifest by the number of copies of HIV RNA per milliliter of plasma, is a major determinant of outc
- Infection with human immunodeficiency virus, an epidemic out of control: personal reflections.
- J Infect Dis. 1999 Mar;179 Suppl 2:S387-90. Unique Identifier : AIDSLINE MED/99181354
- Sande MA; Department of Internal Medicine, University of Utah, Salt Lake; City 84132, USA.
- Serum cyrptococcal antigen: diagnostic value in the diagnosis of AIDS-related cryptococcal meningitis.
- J Med Assoc Thai. 1999 Jan;82(1):65-71. Unique Identifier : AIDSLINE MED/99187705
- Asawavichienjinda T; Sitthi-Amorn C; Tanyanont V; Department of Medicine, Maharaj Nakhon Ratchasima Hospital,; Nakhon Ratchasima, Thailand.
- RATIONALE: The incidences of HIV-AIDS patients with opportunistic infections of the central nervous system are increasing. Of these, cryptococcal meningitis is the most important and serious. A simple method for the diagnosis of cryptococcal meningitis is needed despite its variable clinical features and the lack of a
- Activation of cyclin A gene expression by the cyclin encoded by human herpesvirus-8.
- J Gen Virol. 1999 Mar;80 ( Pt 3):549-55. Unique Identifier : AIDSLINE MED/99190413
- Duro D; Schulze A; Vogt B; Bartek J; Mittnacht S; Jansen-Durr P; Deutsches Krebsforschungszentrum, Forschungsschwerpunkt; Angewandte Tumorvirologie, Heidelberg, Germany.
- Human herpesvirus-8 (HHV-8), also known as Kaposi s sarcoma-associated herpesvirus, encodes a protein, referred to as HHV8-Vcyc, with sequence similarity to human G1 cyclins, in particular of the D type. HHV8-Vcyc is expressed in Kaposi s sarcoma and functional analysis suggests that it can activate cyclin-dependent k
- Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) encodes a homologue of the Epstein-Barr virus bZip protein EB1.
- J Gen Virol. 1999 Mar;80 ( Pt 3):557-61. Unique Identifier : AIDSLINE GENBANK/AJ011499
- Gruffat H; Portes-Sentis S; Sergeant A; Manet E; Laboratoire de virologie humaine, U412 INSERM, ENS-Lyon, France.; hgruffat@cri.ens-lyon.fr
- Analysis of the recently completed genomic sequence of Kaposi s sarcoma-associated herpesvirus (human herpesvirus-8) revealed that ORF 50 encodes a protein with homology to the Epstein-Barr virus (EBV) transcription factor R. In this report, we show that ORF K8, contiguous to ORF 50, is interrupted by two introns and
- Functional analysis of mutations conferring lamivudine resistance on hepatitis B virus.
- J Gen Virol. 1999 Mar;80 ( Pt 3):601-6. Unique Identifier : AIDSLINE MED/99190419
- Ling R; Harrison TJ; Department of Medicine, Royal Free and University College Medical; School, University College London, UK.
- Two patterns of mutation are commonly observed in the polymerase gene of lamivudine [(-)2 -deoxy-3 -thiacytidine]-resistant hepatitis B virus (HBV). The M539I substitution in the conserved YMDD motif occurs independently of other changes, whereas the M539V substitution is associated with an additional upstream change
- Demonstration of bovine CD8+ T-cell responses to foot-and-mouth disease virus.
- J Gen Virol. 1999 Mar;80 ( Pt 3):663-9. Unique Identifier : AIDSLINE MED/99190427
- Childerstone AJ; Cedillo-Baron L; Foster-Cuevas M; Parkhouse RM; Division of Immunology, Institute for Animal Health, Woking,; Surrey, UK. amanda.childerstone@bbsrc.ac.uk
- The aim of this study was to investigate the importance of cellular immunity in foot-and-mouth disease in cattle, in particular to determine whether a CD8+ T-cell response could be detected, as these cells may play a role in both immunity and virus persistence. As attempts to characterize classical cytotoxic T cells h
- Vaccination with experimental feline immunodeficiency virus vaccines, based on autologous infected cells, elicits enhancement of homologous challenge infection.
- J Gen Virol. 1999 Mar;80 ( Pt 3):761-5. Unique Identifier : AIDSLINE MED/99190438
- Karlas JA; Siebelink KH; Peer MA; Huisman W; Cuisinier AM; Rimmelzwaan GF; Osterhaus AD; Institute of Virology, Erasmus University Rotterdam, The; Netherlands.
- Cats were vaccinated with fixed autologous feline immunodeficiency virus (FIV)-infected cells in order to present viral proteins to the immune system of individual cats in an MHC-matched fashion. Upon vaccination, a humoral response against Gag was induced. Furthermore, virus-neutralizing antibodies were detected in a
- Secretion of beta-chemokines by bronchoalveolar lavage cells during primary infection of macaques inoculated with attenuated nef-deleted or pathogenic simian immunodeficiency virus strain mac251.
- J Gen Virol. 1999 Mar;80 ( Pt 3):767-76. Unique Identifier : AIDSLINE MED/99190439
- Caufour P; Le Grand R; Cheret A; Neildez O; Theodoro F; Boson B; Vaslin B; Dormont D; CEA, Service de Neurovirologie, IPSC, Fontenay aux Roses, France.
- Primary infection of macaques with simian immunodeficiency virus (SIV) as a model of human immunodeficiency virus (HIV) infection represents a unique opportunity to investigate early lentivirus-host interactions. In order to gain insight into immunopathogenic events taking place in the lung during lentiviral infection
- Translational effects of peptide antagonists of Tat protein of human immunodeficiency virus type 1.
- J Gen Virol. 1999 Mar;80 ( Pt 3):777-82. Unique Identifier : AIDSLINE MED/99190440
- Choudhury I; Wang J; Stein S; Rabson A; Leibowitz MJ; UMDNJ-Robert Wood Johnson Medical School, Department of Molecular; Genetics and Microbiology, Piscataway, NJ 08854-5635, USA.
- The Tat (trans-activator of transcription) regulatory protein of human immunodeficiency virus (HIV-1) acts by interacting with the TAR RNA domain of nascent viral transcripts and with cellular proteins to increase viral transcription. In Jurkat-derived HCLE-D36 cells, which are stably transfected with the chlorampheni
- Interactions between beta-herpesviruses and human immunodeficiency virus in vivo: evidence for increased human immunodeficiency viral load in the presence of human herpesvirus 6.
- Unique Identifier : AIDSLINE MED/99145398
- Emery VC; Atkins MC; Bowen EF; Clark DA; Johnson MA; Kidd IM; McLaughlin JE; Phillips AN; Strappe PM; Griffiths PD
- In vitro, beta-herpesviruses can stimulate or inhibit HIV replication under particular circumstances. In order to investigate the effects of beta-herpesvirus infection on HIV replication and vice versa at an organ level, we determined the quantitative relationships between cytomegalovi
- Comparison of line probe assay (LIPA) and sequence analysis for detection of HIV-1 drug resistance.
- J Med Virol. 1999 Mar;57(3):283-9. Unique Identifier : AIDSLINE MED/99145399
- Puchhammer-Stockl E; Schmied B; Mandl CW; Vetter N; Heinz FX; Institute of Virology, University of Vienna, Austria.
- The identification of HIV strains that are resistant to antiretroviral drugs, which emerge during a patient s therapy or are already present in infected individuals prior to treatment, is of increasing importance for the clinical management of HIV-infected persons. Two different methods were compared for the genotypic
- Poor women living with HIV: self-identified needs.
- J Community Health Nurs. 1999;16(1):41-52. Unique Identifier : AIDSLINE MED/99191575
- Bunting SM; Bevier DJ; Baker SK; Department of Community Nursing, Medical College of Georgia,; School of Nursing, Augusta 30912-4250, USA. smbunting@Juno.com
- Women with HIV are a growing at-risk population in our communities. They are often poor members of minority groups who have responsibilities for dependent children and other family members. They may experience physiological, psychological, and social symptoms and have needs that are unique to them as women. The purpos
- HIV infection in U.S. correctional systems: its effect on the community.
- J Community Health Nurs. 1999;16(1):53-63. Unique Identifier : AIDSLINE MED/99191576
- Leh SK; Visiting Nurse Association of Pottstown and Vicinity, Montgomery; County Community College, PA 19464, USA.
- Increased rates of HIV infection and risk-taking behaviors among incarcerated men and women make the fight against HIV within the prison and jail systems an especially critical issue in community health. Overcrowded conditions impact on the rotation of inmates in and out of the correctional system. This revolving door
- Use of indirectly immobilized recombinant p17 antigen for detection of antibodies to HIV-1 by enzyme immunoassay.
- J Clin Lab Anal. 1999;13(1):9-18. Unique Identifier : AIDSLINE MED/99148599
- Ishikawa S; Hashinaka K; Hashida S; Oka S; Ishikawa E; Department of Biochemistry, Miyazaki Medical College, Kiyotake,; Japan.
- Recombinant HIV-1 p17 antigen (rp17) and maltose binding protein-rp17 fusion protein (MBP-rp17) were immobilized in different ways: rp17 and MBP-rp17 were immobilized directly onto polystyrene beads by physical adsorption, and biotinyl-rp17, biotinyl-MBP-rp17, and 2,4-dinitrophenyl (DNP)-MBP-rp17 were immobilized indi
- Oral manifestations of HIV infection in a group of predominantly ethnic Chinese.
- J Oral Pathol Med. 1999 Mar;28(3):122-7. Unique Identifier : AIDSLINE MED/99167070
- Tsang PC; Samaranayake LP; Faculty of Dentistry, University of Hong Kong, Hong Kong.
- A total of 32 HIV-infected, predominantly ethnic Chinese individuals from Hong Kong were examined for oral mucosal lesions over a period of 1 year. The commonest oral lesion found was minor aphthous ulceration (27.4%), while xerosto
- A general and fast scoring function for protein-ligand interactions: a simplified potential approach.
- J Med Chem. 1999 Mar 11;42(5):791-804. Unique Identifier : AIDSLINE MED/99173934
- Muegge I; Martin YC; Pharmaceutical Products Division, Abbott Laboratories, Abbott; Park, Illinois 60064-6100, USA. ingo.muegge.b@bayer.com
- A fast, simplified potential-based approach is presented that estimates the protein-ligand binding affinity based on the given 3D structure of a protein-ligand complex. This general, knowledge-based approach exploits structural information of known protein-ligand complexes extracted from the Brookhaven Protein Data Ba
- Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase.
- J Med Chem. 1999 Mar 11;42(5):859-67. Unique Identifier : AIDSLINE MED/99173939
- Shi J; McAtee JJ; Schlueter Wirtz S; Tharnish P; Juodawlkis A; Liotta DC; Schinazi RF; Department of Pediatrics, Emory University, Atlanta, Georgia; 30322, USA.
- The discovery of a novel cytosine nucleoside, beta-D-2 , 3 -didehydro-2 ,3 -dideoxy-5-fluorocytidine (D-D4FC), as a potent antihuman immunodeficiency virus (HIV) agent led us to synthesize a series of analogues and derivatives of beta-D-D4FC that could be more selective and also possess increased glycosidic bond stabi
- Prediction of the binding free energies of new TIBO-like HIV-1 reverse transcriptase inhibitors using a combination of PROFEC, PB/SA, CMC/MD, and free energy calculations.
- J Med Chem. 1999 Mar 11;42(5):868-81. Unique Identifier : AIDSLINE MED/99173940
- Eriksson MA; Pitera J; Kollman PA; Department of Pharmaceutical Chemistry and Graduate Group in; Biophysics, University of California at San Francisco, San; Francisco, California 94143-0446, USA.
- We have ranked 13 different TIBO derivatives with respect to their relative free energies of binding using two approximate computational methods: adaptive chemical Monte Carlo/molecular dynamics (CMC/MD) and Poisson-Boltzmann/solvent accessibility (PB/SA) calculations. Eight of these derivatives have experimentally de
- Synthesis and antiparasitic and antitumor activity of 2, 4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim.
- J Med Chem. 1999 Mar 25;42(6):1007-17. Unique Identifier : AIDSLINE MED/99192591
- Rosowsky A; Papoulis AT; Forsch RA; Queener SF; Dana-Farber Cancer Institute, Department of Biological Chemistry; Harvard Medical School, Boston, Massachusetts 02115, USA.
- Nineteen previously undescribed 2,4-diamino-6-(arylmethyl)-5,6,7, 8-tetrahydroquinazolines (5a-m, 10-12) were synthesized as part of a larger effort to assess the therapeutic potential of lipophilic dihydrofolate reductase (DHFR) inhibitors against opportunistic infections of AIDS. Condensation of appropriately substi
- Design, synthesis, and evaluation of conformationally constrained tongs, new inhibitors of HIV-1 protease dimerization.
- J Med Chem. 1999 Mar 25;42(6):957-62. Unique Identifier : AIDSLINE MED/99192585
- Bouras A; Boggetto N; Benatalah Z; de Rosny E; Sicsic S; Reboud-Ravaux M; BIOCIS, URA-CNRS 1843, Faculte de Pharmacie, Universite de; Paris-sud, 5 rue J. B. Clement, F-92296 Chatenay-Malabry Cedex,; France.
- The active form of human immunodeficiency virus type 1 protease (HIV-1 PR) is a homodimeric structure in which two subunits are linked through a two-stranded antiparallel beta-sheet consisting of the N- and C-termini of each monomer. To inhibit the dimerization process or disrupt the dimeric interface leading to inact
- Diversity analysis of 14 156 molecules tested by the National Cancer Institute for anti-HIV activity using the quantitative structure-activity relational expert system MCASE.
- J Med Chem. 1999 Mar 25;42(6):992-8. Unique Identifier : AIDSLINE MED/99192589
- Klopman G; Tu M; Department of Chemistry, Case Western Reserve University,; Cleveland, Ohio 44106, USA.
- Using the MCASE program, a procedure to analyze the diversity of the large amount of available HIV-1 antiviral data was proposed. A subset of 1 819 chemicals was logically selected from the original 14 156 chemicals tested by NCI. This subset of chemicals was shown to contain most of the structural and the functional
- Demodex gatoi: new species of hair follicle mite (Acari: Demodecidae) from the domestic cat (Carnivora: Felidae).
- J Med Entomol. 1999 Mar;36(2):167-70. Unique Identifier : AIDSLINE MED/99183322
- Desch CE Jr; Stewart TB; Department of Veterinary Microbiology & Parasitology, School of; Veterinary Medicine, Louisiana State University, Baton Rouge,; 70803-8416, USA.
- Demodex gatoi sp. nov. is described in all its life stages from the domestic cat. The host was diagnosed with presumptive feline acquired immunodeficiency syndrome and harbored enormous numbers of both D. gatoi and D. cati Hirst, 1919. Unlike D. cati, which inhabits the hair follicles, D. gatoi resides on the epiderma
- X-ray structure and conformational dynamics of the HIV-1 protease in complex with the inhibitor SDZ283-910: agreement of time-resolved spectroscopy and molecular dynamics simulations.
- J Mol Biol. 1999 Mar 5;286(4):1147-59. Unique Identifier : AIDSLINE MED/99158817
- Ringhofer S; Kallen J; Dutzler R; Billich A; Visser AJ; Scholz D; Steinhauser O; Schreiber H; Auer M; Kungl AJ; Institut fur Theoretische Chemie, Universitat Wien,; Wahringerstr. 17, Wien, A-1090, Austria.
- Based on the X-ray structure of the human immunodeficiency virus type-1 (HIV-1) protease in complex with the statine-derived inhibitor SDZ283-910, a 542 ps molecular dynamics trajectory was computed. For comparison with the 805 ps trajectory obtained for the uncomplexed enzyme, the theoretical fluorescence anisotropy
- Analysis of amino insertion mutations in the fingers subdomain of HIV-1 reverse transcriptase.
- J Mol Biol. 1999 Mar 5;286(4):995-1008. Unique Identifier : AIDSLINE MED/99158806
- Boyer PL; Lisziewicz J; Lori F; Hughes SH; ABL-Basic Research Program, NCI-Frederick Cancer Research and; Development Center, Frederick, MD, 21702-1201, USA.
- In response to dideoxy inosine/hydroxyurea dual therapy, HIV-1 (human immunodeficiency virus type-1) variants were isolated that had a small amino acid insertion and flanking amino acid substitutions in the fingers subdomain of HIV-1. We have analyzed the reverse transcriptase variants for their effects on HIV-1 rever
- Binding properties of the human immunodeficiency virus type 1 nucleocapsid protein p7 to a model RNA: elucidation of the structural determinants for function.
- J Mol Biol. 1999 Mar 19;287(1):59-75. Unique Identifier : AIDSLINE MED/99175320
- Urbaneja MA; Kane BP; Johnson DG; Gorelick RJ; Henderson LE; Casas-Finet JR; AIDS Vaccine Program, SAIC Frederick, National Cancer; Institute-Frederick Cancer Research and Development Center,; Frederick, MD, 21702-1201, USA. urbaneja@avpaxpl.ncifcrf.gov
- HIV-1 nucleocapsid protein (NCp7) is a double zinc-fingered protein that has been traditionally implicated in viral RNA recognition and packaging, in addition to its tight association with genomic RNA and tRNA primer within the virion nucleocapsid. The availability of large quantities of viral or recombinant wild-type
- Coevolution and subsite decomposition for the design of resistance-evading HIV-1 protease inhibitors.
- J Mol Biol. 1999 Mar 19;287(1):77-92. Unique Identifier : AIDSLINE MED/99175321
- Rosin CD; Belew RK; Walker WL; Morris GM; Olson AJ; Goodsell DS; Department of Molecular Biology, The Scripps Research Institute,; La Jolla, CA, 92037, USA.
- Drug resistance sharply limits the effectiveness of human immunodeficiency virus (HIV) protease inhibitors in acquired immunodeficiency syndrome therapy. In previous work, we presented methods for design of resistance-evading inhibitors using a computational coevolu
- Peptides derived from HIV-1 Vif: a non-substrate based novel type of HIV-1 protease inhibitors.
- J Mol Biol. 1999 Mar 19;287(1):93-101. Unique Identifier : AIDSLINE MED/99175322
- Friedler A; Blumenzweig I; Baraz L; Steinitz M; Kotler M; Gilon C; Department of Organic Chemistry, The Hebrew University, Givat; Ram, 91904, Israel.
- The retroviral protease (PR) is absolutely essential for completion of human immunodeficiency virus multiplication cycle, and cannot be replaced by any cellular function. Thus PR, like reverse transcriptase, is an ideal target for the development of anti-AIDS therapy. A large number of human immunodeficiency virus typ
- Codon bias and mutability in HIV sequences.
- J Mol Evol. 1999 Apr;48(4):390-7. Unique Identifier : AIDSLINE MED/99180674
- Stephens CR; Waelbroeck H; Instituto de Ciencias Nucleares, UNAM, Circuito Exterior,; Apartado Postal 70-543, Mexico D.F. 04510, Mexico.
- A survey of the patterns of synonymous codon preference in the HIV env gene reveals a correlation between the codon bias and the mutability requirements of different regions of the protein. At hypervariable regions in gp120 one finds a greater proportion of codons that tend to mutate nonsynonymously, but to a target t
- Southern states have largest number of AIDS cases.
- J Natl Med Assoc. 1999 Jan;91(1):13. Unique Identifier : AIDSLINE MED/99163270
- Relative rates of AIDS among racial/ethnic groups by exposure categories.
- J Natl Med Assoc. 1999 Jan;91(1):17-24. Unique Identifier : AIDSLINE MED/99163271
- Haverkos HW; Turner JF Jr; Moolchan ET; Cadet JL; National Institute of Drug Abuse, National Institutes of Health,; Baltimore, Maryland, USA.
- The relative rates of acquired immunodeficiency syndrome (AIDS) were calculated among racial/ethnic populations using Centers for Disease Control and Prevention HIV (human immunodeficiency virus)/Surveillance reports assuming that racial/ethnic distributions reflect that of the US Census Data from 1990. For comparison
- From the Centers for Disease Control and Prevention. HIV postexposure prophylaxis registry closing.
- JAMA. 1999 Apr 7;281(13):1167. Unique Identifier : AIDSLINE MED/99213507
- [Current topics in the regulation of prostanoids--2. The interaction with cytokines and nitric oxide]
- Masui. 1998 Dec;47(12):1471-7. Unique Identifier : AIDSLINE MED/99144027
- Ohara M; Sawa T; Department of Anesthesiology, Yokohama City University, School of; Medicine.
- Cyclooxygenase (COX)-2 is induced by proinflammatory cytokines such as interleukin (IL)-1 beta, cytokines produced from helper T cell subpopulation Th 1, such as interferon-gamma and tumor necrosis factor-beta. Cytokines produced by the T cell such as IL-4, IL-10, and IL-13 down-regulate induction of COX-2. The novel
- Recruitment of renal tubular epithelial cells expressing verotoxin-1 (Stx1) receptors in HIV-1 transgenic mice with renal disease.
- Kidney Int. 1999 Feb;55(2):554-61. Unique Identifier : AIDSLINE MED/99141552
- Liu XH; Lingwood CA; Ray PE; Children's Research Institute, Children's National Medical; Center, Washington D.C., USA.
- BACKGROUND: Human immunodeficiency virus (HIV)-infected children are at risk of developing several renal parenchymal diseases, including hemolytic uremic syndrome (HUS). HUS is most frequently caused by infection with enteric Escherichia coli producing Shiga-like toxins (Stxs). In vitro studies have shown that cytokin
- Increased levels of transforming growth factor-beta in HIV-associated nephropathy.
- Kidney Int. 1999 Feb;55(2):579-92. Unique Identifier : AIDSLINE MED/99141555
- Yamamoto T; Noble NA; Miller DE; Gold LI; Hishida A; Nagase M; Cohen AH; Border WA; Division of Nephrology and Hypertension, University of Utah; School of Medicine, Salt Lake City, USA.
- BACKGROUND: Human immunodeficiency virus-associated nephropathy (HIVAN) is a renal disease of unknown pathogenesis. Recent evidence suggests that the fibrogenic cytokine transforming growth factor-beta (TGF-beta) might be involved. We hypothesized that overproduction of TGF-beta in the kidney might be involved in the
- [Clinical course of cryptococcosis in HIV infection]
- Klin Med (Mosk). 1999;77(1):39-42. Unique Identifier : AIDSLINE MED/99197578
- Rakhmanova AG; Giaurgieva OKh
- Cryptococcosis was detected in 17% of examines with AIDS. The disease was caused by fungus Cryptococcus neoformans. Most frequently cryptococcosis affected CNS (meningitis and encephalitis). The symptoms were scare and nonspecific, e.g. positive meningitis indicators occurred only in 9% of the patients. Cryptococcosis
- Animal models of human microsporidial infections.
- Unique Identifier : AIDSLINE MED/99189951
- Snowden KF; Didier ES; Orenstein JM; Shadduck JA; Department of Veterinary Pathobiology, College of Veterinary; Medicine, Texas A & M University, College Station, USA.
- Two new models have been described for Enterocytozoon bieneusi, non-human primates and immuno-suppressed gnotobiotic pigs, but there still is no successful cell culture system. The intestinal xenograft system holds promise as an animal model for Encephalitozoon intestinalis. Encephalitozoon hellem is easily propagated
- Expression of CD40/CD40 ligand and Bcl-2 family proteins in labial salivary glands of patients with Sjogren's syndrome.
- Lab Invest. 1999 Mar;79(3):261-9. Unique Identifier : AIDSLINE MED/99190483
- Nakamura H; Kawakami A; Tominaga M; Migita K; Kawabe Y; Nakamura T; Eguchi K; First Department of Internal Medicine, Nagasaki University School; of Medicine, Nagasaki City, Japan.
- Lymphocytes infiltrating the salivary glands of patients with Sjogren s syndrome (SS) are activated and resist apoptosis. We determined the role of interactions between CD40 and CD40 ligand (CD40L) in these infiltrating lymphocytes on B-cell differentiation and expression of Bcl-2 family proteins. Ten human T-cell leu
- Variation in inpatient resource use in the treatment of HIV: do the privately insured receive more care?
- Med Care. 1999 Mar;37(3):220-7. Unique Identifier : AIDSLINE MED/99196202
- Joyce GF; Goldman DP; Leibowitz A; Carlisle D; Duan N; Shapiro MF; Bozzette SA; Rand Health Sciences Program, Santa Monica, CA 90407-2138, USA.; gjoyce@rand.org
- OBJECTIVE: To estimate the impact of insurance status on inpatient resource use after adjusting for health upon admission and site of care. DESIGN: Detailed patient information linked to billing records from the AIDS Cost and Service Utilization Survey (ACSUS), a longitudinal analysis of inpatient and outpatient care
- Application of random effects models and other methods to the analysis of multidimensional quality of life data in an AIDS clinical trial.
- Med Care. 1999 Mar;37(3):249-58. Unique Identifier : AIDSLINE MED/99196205
- Wu AW; Gray SM; Brookmeyer R; Department of Health Policy and Management, Johns Hopkins; University, Baltimore, MD, USA. awu@jhsph.edu
- BACKGROUND: Current analytic methods applied to multidimensional health-related quality of life (HRQOL) data do not borrow strength across analyses and do not produce summary estimates of effect. OBJECTIVES: To compare a random effects modelling approach for the analysis of multidimensional HRQOL data to the following
- [Tuberculosis trends in Barcelona (1987-1995). Impact of the human immunodeficiency virus and control measures]
- Med Clin (Barc). 1998 Nov 14;111(16):608-15. Unique Identifier : AIDSLINE MED/99098009
- Cayla JA; Galdos-Tanguis H; Jansa JM; Garcia de Olalla P; Brugal T; Panella H
- BACKGROUND: To study the epidemiology to tuberculosis (TB) in Barcelona, Spain from 1987 to 1995, analyzing the influence of HIV infection and the impact of control measures. PATIENTS, MATERIAL AND METHODS: All cases detected by the Barcelona Tuberculosis Prevention and Control Prog
- [Tuberculosis and AIDS 15 years later (1981-1996): new perspectives]
- Med Clin (Barc). 1998 Nov 14;111(16):628-34. Unique Identifier : AIDSLINE MED/99098013
- de March Ayuela P; Garcia Gonzalez A; Institut Municipal de la Salut de Barcelona.
- [Antiretroviral treatment (letter)]
- Med Clin (Barc). 1998 Nov 14;111(16):637-8. Unique Identifier : AIDSLINE MED/99098016
- Pardo Serrano FJ; Munoz RM; Sabater Vidal S; Gil Fortuno M
- [Influence of pregnancy in chronic hepatitis C virus infection]
- Med Clin (Barc). 1998 Nov 21;111(17):641-4. Unique Identifier : AIDSLINE MED/99098019
- Romero-Gomez M; Suarez-Garcia E; Casanovas J; Nogales MC; Vargas J; Otero MA; Castro Fernandez M; Seccion de Aparato Digestivo, Hospital Universitario de Valme,; Sevilla.
- BACKGROUND: There is scarce information about the influence of pregnancy in patients with chronic hepatitis C virus infection is little know. PATIENTS AND METHODS: 6,556 pregnant women were screened for anti-HCV (ELISA II). We determine ALT, HCV-RNA by PCR (Amplicor Roche) and HCV viraemia (Amplicor-HCV-Monitor Roche)
- [Non-nucleoside reverse transcriptase inhibitors of the human immunodeficiency virus (editorial)]
- Med Clin (Barc). 1998 Nov 21;111(17):660-2. Unique Identifier : AIDSLINE MED/99098024
- Roca B; Simon E
- [AIDS associated with tuberculosis in prisons (letter)]
- Med Clin (Barc). 1998 Nov 21;111(17):677-9. Unique Identifier : AIDSLINE MED/99098033
- Marco A; Guerrero RA; Valls I; Busquets E
- Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients: a prospective cohort study. Swiss HIV Cohort Study.
- Lancet. 1999 Mar 13;353(9156):863-8. Unique Identifier : AIDSLINE MED/99191765
- Ledergerber B; Egger M; Opravil M; Telenti A; Hirschel B; Battegay M; Vernazza P; Sudre P; Flepp M; Furrer H; Francioli P; Weber R; Division of Infectious Diseases and Hospital Epidemiology,; University of Zurich, Switzerland. infled@usz.unizh.ch
- BACKGROUND: The efficacy of highly active antiretroviral therapy (HAART) in suppression of HIV-1 is well documented. We investigated virological and clinical outcomes of HAART in routine practice. METHODS: We analysed prospective data from the Swiss HIV Cohort Study on suppression of viral load and progression to AIDS
- Riboflavine and severe lactic acidosis [letter]
- Lancet. 1999 Mar 13;353(9156):901-2. Unique Identifier : AIDSLINE MED/99191780
- Luzzati R; Del Bravo P; Di Perri G; Luzzani A; Concia E
- Needle-exchange programmes are not the answer [letter]
- Lancet. 1999 Mar 13;353(9156):930. Unique Identifier : AIDSLINE MED/99191805
- Bellm J
- The stability of preferences for life-sustaining care among persons with AIDS in the Boston Health Study.
- Med Decis Making. 1999 Jan-Mar;19(1):16-26. Unique Identifier : AIDSLINE MED/99114054
- Weissman JS; Haas JS; Fowler FJ Jr; Gatsonis C; Massagli MP; Seage GR 3rd; Cleary P; Department of Health Care Policy, Harvard Medical School Boston,; Massachusetts, USA.
- BACKGROUND: Clinicians recognize the importance of eliciting patient preferences for life-sustaining care, yet little is known about the stability of those preferences for patients with serious disease. OBJECTIVES: To examine the stability of preferences for life-sustaining care among persons with AIDS and to assess f
- The force of numbers: why hepatitis C is spreading among Australian injecting drug users while HIV is not.
- Med J Aust. 1999 Mar 1;170(5):220-1. Unique Identifier : AIDSLINE MED/99192880
- Crofts N; Aitken CK; Kaldor JM; Centre for Harm Reduction, Macfarlane Burnet Centre for Medical; Research, Fairfield, VIC. crofts@burnet.edu.au
- Oral ganciclovir for patients with cytomegalovirus retinitis treated with a ganciclovir implant. Roche Ganciclovir Study Group [see comments]
- N Engl J Med. 1999 Apr 8;340(14):1063-70. Unique Identifier : AIDSLINE MED/99192002
- Martin DF; Kuppermann BD; Wolitz RA; Palestine AG; Li H; Robinson CA; Department of Ophthalmology, Emory University School of Medicine,; Atlanta, GA 30322, USA. dmart04@emory.edu
- BACKGROUND: The intraocular ganciclovir implant is effective for local treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome (AIDS), but it does not treat or prevent other systemic manifestations of cytomegalovirus infection. METHODS: Three
- Cytomegalovirus retinitis--evolving therapies in a new era [editorial; comment]
- N Engl J Med. 1999 Apr 8;340(14):1109-10. Unique Identifier : AIDSLINE MED/99192010
- Whitley RJ; Holland GN
- Bragdon v. Abbott: the Americans with Disabilities Act and HIV infection [letter]
- N Engl J Med. 1999 Apr 15;340(15):1212-3; discussion 1213-4. Unique Identifier : AIDSLINE MED/99200762
- Tessman I
- Bragdon v. Abbott: the Americans with Disabilities Act and HIV infection [letter]
- N Engl J Med. 1999 Apr 15;340(15):1213; discussion 1213-4. Unique Identifier : AIDSLINE MED/99200763
- Neiburger EJ
- Bragdon v. Abbott: the Americans with Disabilities Act and HIV infection [letter]
- N Engl J Med. 1999 Apr 15;340(15):1213-4. Unique Identifier : AIDSLINE MED/99200764
- Greely HT
- An unusual presentation of paracoccidioidomycosis in an AIDS patient: a case report.
- Mycopathologia. 1998;142(3):139-42. Unique Identifier : AIDSLINE MED/99161315
- dos Santos JW; Costa JM; Cechella M; Michel GT; de Figueiredo CW; Londero AT; Pulmonary Disease Service, Hospital of Santa Maria, RS, Brazil.; jwell@husm.ufsm.br
- A case of paracoccidioidomycosis presenting as a solitary pulmonary nodular lesion in a patient with acquired immunodeficiency syndrome (AIDS) is presented. This case illustrates that restricted lung lesions can also be found and diagnosed in immunodeficient patients.
- Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells.
- Nature. 1999 Mar 25;398(6725):341-4. Unique Identifier : AIDSLINE MED/99206553
- Kurts C; Carbone FR; Krummel MF; Koch KM; Miller JF; Heath WR; The Department of Nephrology, Medizinische Hochschule, Hannover,; Germany.
- Autoantigens found on pancreatic islets can move to draining lymph nodes, where they are able to cause the activation and consequent deletion of autoreactive T cells by a mechanism termed cross-tolerance. This deletion depends on signalling through CD95 (also known as Fas), a member of the superfamily of tumour-necros
- [Lipodystrophy and 'buffalo hump' during treatment with HIV protease inhibitors]
- Ned Tijdschr Geneeskd. 1998 Dec 26;142(52):2856-60. Unique Identifier : AIDSLINE MED/99164654
- Dieleman JP; Hillebrand-Haverkort ME; van der Ende ME; Sturkenboom MC; Lange JM; Stricker BH; Sectie Farmaco-epidemiologie van de afdelingen Epidemiologie en; Biostatistiek en Inwendige Geneeskunde, Erasmus Medisch Centrum,; Rotterdam.
- In three patients, a 36-year-old HIV seropositive homosexual man and two women aged 35 and 59 years who had acquired HIV infection through heterosexual contact, signs of lipodystrophy developed after prolonged anti-HIV triple therapy. The observed syndrome is seen after prolonged use of HIV
- [Surveillance of AIDS and HIV infections in Amsterdam, 1997]
- Ned Tijdschr Geneeskd. 1998 Dec 26;142(52):2861-5. Unique Identifier : AIDSLINE MED/99164655
- van den Hoek JA; Mulder-Folkerts DK; Dukers NH; Fennema JS; Coutinho RA; Gemeentelijke Geneeskundige en Gezondheidsdienst, divisie; Volksgezondheid en Milieu, Amsterdam.
- Data were collected in Amsterdam in 1997 from the aids surveillance, from the HIV surveillance among pregnant women and visitors of a clinic for sexually transmitted diseases (STD), and from two alternative HIV test sites, using various survey systems. The findings were compared with those of previous years. Aids wa
- [Memisa and home care for AIDS patients in Zambia]
- Ned Tijdschr Geneeskd. 1999 Jan 16;143(3):162-5. Unique Identifier : AIDSLINE MED/99186053
- Reijer PJ; Memisa Medicus Mundi, Rotterdam.
- Health care in Zambia has since long been receiving support from non-governmental organizations (NGOs) like Memisa. Church organizations bear responsibility for a considerable part of the national health services. During the last 15 years, growing attention has been given to improv
- Retinal pigment epithelial dysfunction in human immunodeficiency virus-infected patients with cytomegalovirus retinitis.
- Ophthalmology. 1999 Apr;106(4):790-7. Unique Identifier : AIDSLINE MED/99215787
- Harrison JM; van Heuven WA; Department of Ophthalmology, The University of Texas Health; Science Center at San Antonio, 78284-6230, USA.
- OBJECTIVE: Prior clinical observations led the authors to examine electrophysiologic measures of retinal (electroretinogram [ERG]) and retinal pigment epithelial (electro-oculogram [EOG]) function in patients infected with human immunodeficiency virus (HIV) who either had or did not have
- Visualizing tertiary folding of RNA and RNA-protein interactions by a tethered iron chelate: analysis ofHIV-1 Tat-TAR complex.
- Nucleic Acids Res. 1999 Feb 15;27(4):1084-93. Unique Identifier : AIDSLINE MED/99128298
- Huq I; Tamilarasu N; Rana TM; Department of Pharmacology, Robert Wood Johnson Medical School,; 675 Hoes Lane, Piscataway, NJ 08854, USA.
- Replication of human immunodeficiency virus type 1 (HIV-1) requires specific interactions of Tat protein with the trans activation responsive region (TAR) RNA, a 59 base stem-loop structure located at the 5 -end of all HIV transcripts. We have used an intramolecular RNA self-cleaving strategy to determine the folding
- Molecular basis for the enantioselectivity of HIV-1 reverse transcriptase: role of the 3'-hydroxyl group of the L-(beta)-ribose in chiral discrimination between D- and L-enantiomers of deoxy- and dideoxy-nucleoside triphosphate analogs.
- Nucleic Acids Res. 1999 Feb 15;27(4):972-8. Unique Identifier : AIDSLINE MED/99128283
- Maga G; Amacker M; Hubscher U; Gosselin G; Imbach JL; Mathe C; Faraj A; Sommadossi JP; Spadari S; Institute of Biochemical and Evolutionary Genetics, National; Research Council, I-27100, Pavia, Italy. maga@igbe.pv.cnr.it
- In order to identify the basis for the relaxed enantio-selectivity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) and to evaluate possible cross-resistance patterns between L-nucleoside-, D-nucleoside- and non-nucleoside RT inhibitors, to be utilised in anti-HIV-1
- Ivermectin-responsive crusted scabies in four patients [letter]
- Pediatr Dermatol. 1999 Jan-Feb;16(1):69-70. Unique Identifier : AIDSLINE MED/99152264
- Larralde M; Mijelshon LM; Gonzalez A; Mora E; Constantakos N
- [Discontinuing protease inhibitor treatment of HIV-1 patients for intolerance. Longitudinal study of 309 patients]
- Unique Identifier : AIDSLINE MED/99193554
- Piroth L; Grappin M; Waldner A; Sgro C; Duong M; Buisson M; Chavanet P; Portier H
- OBJECTIVES: Determine the frequency and nature of interruptions in HIV-1 protease inhibitor treatment in HIV-infected patients. PATIENTS AND METHODS: A longitudinal study included patients treated with antiretroviral protocols including at least one
- [Discontinuation of antiretroviral treatment containing a protease inhibitor. Failure and tolerance]
- Presse Med. 1999 Feb 27;28(8):402-4. Unique Identifier : AIDSLINE MED/99193560
- Michelet C
- [Immunologic reconstruction after antiretroviral treatment]
- Presse Med. 1999 Feb 27;28(8):424-8. Unique Identifier : AIDSLINE MED/99193563
- Tubiana R; Carcelain G; Mohand HA; Li TS; Renaud M; Blanc C; Calvez V; Debre P; Agut H; Katlama C; Autran B; Bricaire F; Service des Maladies Infectieuses et Tropicales, Laboratoire de; Virologie, Hopital Pitie-Salpetriere, Paris.
- DATA FAVORING IMMUNE RECONSTITUTION: Multiple drug therapies for HIV infection have enabled a major reduction in the viral load, higher CD4 counts, and a lower incidence of opportunistic infections and tumor formations, and subsequently lower hospitalization rates and mortality. TWO STAGES OF CD4 RECONSTITUTION: In HI
- [Varicella zoster virus infection area in 39 HIV-infected patients. Therapeutic management]
- Presse Med. 1999 Mar 6;28(9):473-5. Unique Identifier : AIDSLINE MED/99205903
- Leautez S; Billaud E; Milpied B; Raffi F; Service de Medecine interne B, Centre Hospitalo-Universitaire,; Hotel Dieu, Nantes.
- OBJECTIVES: The main goal of this study was to assess therapeutic strategies in HIV-infected patients with varicella-zoster virus infection. PATIENTS AND METHODS: This retrospective study conducted between 1989 and 1996 concerned 39 HIV-infected patients who had reached the AIDS stage and had at least one episode of v
- Th1-type cytokines improve resistance to murine cysticercosis caused by Taenia crassiceps.
- Parasitol Res. 1999 Feb;85(2):135-41. Unique Identifier : AIDSLINE MED/99131662
- Terrazas LI; Cruz M; Rodriguez-Sosa M; Bojalil R; Garcia-Tamayo F; Larralde C; Department of Biology, Facultad de Quimica, Universidad Nacional; Autonoma de Mexico, Mexico D.F.
- Resistance and susceptibility to different parasitic diseases have been associated with the predominance of Th1- or Th2-type immune responses. In experimental murine cysticercosis a Th1 response seems to be involved in resistance, whereas Th2 activity is associated with heavy parasite intensities. To test this notion
- Soluble-protein and antigenic heterogeneity in axenic Blastocystis hominis isolates: pathogenic implications.
- Parasitol Res. 1999 Feb;85(2):93-7. Unique Identifier : AIDSLINE MED/99131655
- Lanuza MD; Carbajal JA; Villar J; Mir A; Borras R; Departamento de Microbiologia, Facultad de Medicina, Valencia,; Spain.
- The protein profile and the antigenic cross-reactivity of 18 axenic isolates of Blastocystis hominis obtained from symptomatic patients with chronic diarrhea (14 isolates) showing no evidence of parasitic etiology and from patients with acute diarrhea attributable in 2 cases to Salmonella spp. were analyzed. Sodium do
- Human immunodeficiency virus-rich multinucleated giant cells in the colon: a case report with transmission electron microscopy, immunohistochemistry, and in situ hybridization.
- Mod Pathol. 1999 Jan;12(1):75-81. Unique Identifier : AIDSLINE MED/99133665
- Lewin-Smith M; Wahl SM; Orenstein JM; Armed Forces Institute of Pathology, Washington, DC, USA.
- Multinucleated giant cells (MNGCs) expressing the human immunodeficiency virus (HIV) are characteristically found in hyperplastic tonsils and adenoids, acquired immunodeficiency syndrome encephalitis, vacuolar myelopathy, and lymph nodes coinfected with opportunistic pathogens. We identified similar polykaryons in the
- tRNAVal-heterodimeric maxizymes with high potential as geneinactivating agents: simultaneous cleavage at two sites in HIV-1 Tat mRNA in cultured cells.
- Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):1886-91. Unique Identifier : AIDSLINE MED/99162527
- Kuwabara T; Warashina M; Nakayama A; Ohkawa J; Taira K; National Institute for Advanced Interdisciplinary Research,; Agency of Industrial Science and Technology, Ministry of; International Trade and Industry, Tsukuba Science City 305-8566,; Japan.
- It has been demonstrated that shortened forms of (stem II-deleted) hammerhead ribozymes with low intrinsic activity form very active dimers with a common stem II (very active short ribozymes capable of forming dimers were designated maxizymes). Intracellular activities of heterodimeric maxizymes and conventional riboz
- The RD114/simian type D retrovirus receptor is a neutral amino acid transporter.
- Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2129-34. Unique Identifier : AIDSLINE GENBANK/AF105230
- Rasko JE; Battini JL; Gottschalk RJ; Mazo I; Miller AD; Division of Molecular Medicine, Fred Hutchinson Cancer Research; Center, Seattle, WA 98109-1024, USA.
- The RD114/simian type D retroviruses, which include the feline endogenous retrovirus RD114, all strains of simian immunosuppressive type D retroviruses, the avian reticuloendotheliosis group including spleen necrosis virus, and baboon endogenous virus, use a common cell-surface receptor for cell entry. We have used a
- Coalescent estimates of HIV-1 generation time in vivo.
- Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2187-91. Unique Identifier : AIDSLINE +
- Rodrigo AG; Shpaer EG; Delwart EL; Iversen AK; Gallo MV; Brojatsch J; Hirsch MS; Walker BD; Mullins JI; Department of Microbiology, University of Washington, Seattle, WA; 98195, USA. rodrigo@u.washington.edu
- The generation time of HIV Type 1 (HIV-1) in vivo has previously been estimated using a mathematical model of viral dynamics and was found to be on the order of one to two days per generation. Here, we describe a new method based on coalescence theory that allows the estimate of generation times to be derived by using
- Dopamine beta-hydroxylase deficiency impairs cellular immunity.
- Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2274-8. Unique Identifier : AIDSLINE MED/99162594
- Alaniz RC; Thomas SA; Perez-Melgosa M; Mueller K; Farr AG; Palmiter RD; Wilson CB; Department of Immunology, University of Washington, Seattle, WA; 98195, USA.
- Norepinephrine, released from sympathetic neurons, and epinephrine, released from the adrenal medulla, participate in a number of physiological processes including those that facilitate adaptation to stressful conditions. The thymus, spleen, and lymph nodes are richly innervated by the sympathetic nervous system, and
- Induction of autoantibodies to mouse CCR5 with recombinant papillomavirus particles.
- Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2373-8. Unique Identifier : AIDSLINE MED/99162612
- Chackerian B; Lowy DR; Schiller JT; Laboratory of Cellular Oncology, National Institutes of Health,; Building 36, Room 1D-32, Bethesda, MD 20892-4040, USA.
- The vertebrate immune system has evolved to respond vigorously to microbial infection but to ignore self-antigens. Evidence has emerged that B cell responses to viruses are initiated by immune recognition of ordered arrays of antigen on the viral surface. To test whether autoantibodies against a self-antigen can be in
- Radiographic imaging of Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome.
- Radiat Med. 1998 Nov-Dec;16(6):431-40. Unique Identifier : AIDSLINE MED/99126233
- Asai S; Department of Radiology, Institute of Medical Science, University; of Tokyo, Japan.
- We reviewed the radiographic imaging of Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome to determine the findings of chest radiography, computed tomography, and gallium scintigraphy and to analyze the time course of the resolution of abnormalities on chest radiographs after the initi
- [Amphotericin B associated with severe liver toxicity (letter)]
- Rev Clin Esp. 1999 Jan;199(1):49. Unique Identifier : AIDSLINE MED/99189652
- Campo C; Anton E; Morata C; Lacruz J
- [The hepatitis C virus: after the track of the human immunodeficiency virus (editorial)]
- Rev Clin Esp. 1999 Jan;199(1):5-7. Unique Identifier : AIDSLINE MED/99189639
- Perez-Olmeda M; Rodriguez-Rosado R; Garcia-Samaniego J; Soriano V
- Th1 and Th2 cells.
- Res Immunol. 1998 Nov-Dec;149(9):871-3. Unique Identifier : AIDSLINE MED/99120519
- Romagnani S; Kapsenberg M; Radbruch A; Adorini L; Institute of Internal Medicine and Allergology, University of; Florence, Italy.
- Susceptibility of human lymphoblastoid B-cell line CE to HIV1 infection.
- Res Virol. 1998 Sep-Oct;149(5):307-9. Unique Identifier : AIDSLINE MED/99095682
- Valli MB; Carloni G; Bertolini L; Istituto di Medicina Sperimentale, Roma.
- In this preliminary report, we provide evidence that the human B-lymphoblastoid cell line (LCL) CE, bone-marrow-derived, previously reported to be permissive to hepatitis C virus, is also permissive to HIV1 infection. HIV1 genomes were detectable in cell supernatants, virus RNA transcripts and proviral DNAs in cell ex
- Probing the natural antibody repertoire by combinatorial cloning of IgM and IgD isotypes in phage display vectors.
- Res Virol. 1998 Sep-Oct;149(5):321-5. Unique Identifier : AIDSLINE MED/99095685
- Burioni R; Plaisant P; Bugli F; Delli Carri V; Candela M; Gabrielli A; Fadda G; Istituto di Microbiologia, Facolta di Medicina, Universita; Cattolica del Sacro Cuore, Roma, Italy.
- It is well known that immunoglobulins with no identifiable immunogenic origin, called natural antibodies, are present in the sera of healthy individuals and their role as a defence against important pathogens has been proposed. Unfortunately, the studies are hampered by the fact that these immunoglobulins seem to have
- Consequences of ddI-induced reduction of acute SIVmac251 virus load on cytokine profiles in cynomolgus macaques.
- Res Virol. 1998 Nov-Dec;149(6):341-54. Unique Identifier : AIDSLINE MED/99121765
- Gigout L; Vaslin B; Matheux F; Caufour P; Neildez O; Cheret A; Lebel-Binay S; Theodoro F; Dilda P; Benveniste O; Clayette P; Le Grand R; Dormont D; CEA, Service de Neurovirologie, DSV/DRM, CRSSA, Fontenay aux; Roses, France.
- This study evaluates the consequences of antiretroviral treatment of the acute simian immunodeficiency virus (SIV) primary infection on virus load and cytokine responses. Four cynomolgus macaques were inoculated intravenously with a pathogenic primary isolate (SIVmac251). Animals were pretreated with 10.8 mg/kg/day of
- Mutations in the human immunodeficiency virus type 1 reverse transcriptase gene observed in stavudine and didanosine strains obtained by in vitro passages.
- Res Virol. 1998 Nov-Dec;149(6):355-61. Unique Identifier : AIDSLINE MED/99121766
- Bossi P; Yvon A; Mouroux M; Huraux JM; Agut H; Calvez V; Department of Virology, CERVI, Pitie-Salpetriere Hospital,; Paris, France.
- We have selected a human immunodeficiency virus type 1 (HIV1) using the technique of in vitro selection to generate variants that are resistant to didanosine and/or stavudine . After serial passages of the Lai strain of HIV1 in MT-2 cells in increased
- Structure/antigenicity relationship of cyclic and linear peptides mimicking the V3 loop of HIV2 envelope glycoprotein.
- Res Virol. 1998 Nov-Dec;149(6):363-73. Unique Identifier : AIDSLINE MED/99121767
- Belhadj Jrad B; Massou S; Czaplicki J; Moureau C; Moynier M; Fourquet P; Milon A; Mazie JC; Bahraoui E; Laboratoire d'Immuno-Virologie, Universite Paul Sabatier,; Toulouse, France.
- We report the structure and antigenicity of the third variable region (V3) of the HIV2 envelope glycoprotein by the use of linear and cyclic peptides. To this end, a peptide mimicking this region was synthesized and purified, both as an iodoacetamidated linear peptide and a disulphide-bridged cyclic peptide. The cross
- Identification of membrane antigens important for adsorption of human T-cell leukaemia virus type I.
- Res Virol. 1998 Nov-Dec;149(6):383-92. Unique Identifier : AIDSLINE MED/99121769
- Fu DX; Haraguchi Y; Jinno A; Yang D; Hoshino H; Department of Hygiene and Virology, Gunma University School of; Medicine, Japan.
- We isolated three monoclonal antibodies (mAbs), H3e, H11b and H16h, which were capable of inhibiting syncytium formation induced in a human T-cell line MOLT-4 or a human glioma line U251 MG by coculture with human T-cell leukaemia virus type I (HTLV-I)-positive human T-cell lines. The mAbs partially inhibited the plat
- Selection and characterization of two specific monoclonal antibodies directed against the two variants of human herpesvirus-6.
- Res Virol. 1998 Nov-Dec;149(6):403-11. Unique Identifier : AIDSLINE MED/99121771
- Robert C; Massonneau V; Pothier P; Clement A; Hejblum G; Hubert P; Aubin JT; Agut H; Laboratoire de Virologie, EA 2387, CERVI, Hopital; Pitie-Salpetriere, Paris.
- Monoclonal antibodies (mAbs) specific for human herpesvirus-6 (HHV6) proteins were derived from the splenocytes of mice immunized with HHV6 TAN isolate-infected peripheral blood mononuclear cells. The two mAbs 8C8 and 7C7 reacted by means of immunofluorescence and immunoperoxidase assays with both variant A and varian
- Inducible expression of herpes simplex virus thymidine kinase from a bicistronic HIV1 vector.
- Unique Identifier : AIDSLINE MED/99121773
- Marcello A; Giaretta I; Institute of Microbiology, University of Padova, Italy.
- The possibility of protecting human CD4+ lymphocytes from human immunodeficiency virus type 1 (HIV1) infection, through a suicide mechanism elicited by the HIV1 transcription apparatus itself, offers a potentially useful approach for gene therapy of the acquired immunodeficiency syndrome. A replication-defective lenti
- Primary ocular Epstein-Barr virus-associated non-Hodgkin's lymphoma in a patient with AIDS: a clinicopathologic report.
- Retina. 1999;19(1):45-50. Unique Identifier : AIDSLINE MED/99156117
- Mittra RA; Pulido JS; Hanson GA; Kajdacsy-Balla A; Brummitt CF; The Vitreoretinal Service, Eye Institute, Medical College of; Wisconsin, Milwaukee, USA.
- OBJECTIVE: To report an unusual case of chronic multifocal chorioretinitis with vitritis in a patient with acquired immunodeficiency syndrome (AIDS) that was resistant to antiviral and antitoxoplasmic medication and required a retinal biopsy for definitive diagnosis. METHODS: Vitreous biopsy, pars plana vitrectomy, an
- Vitrectomy and silicone oil tamponade for cidofovir-associated hypotony with ciliary body detachment.
- Retina. 1999;19(1):75-6. Unique Identifier : AIDSLINE MED/99156123
- Lin AP; Holland GN; Engstrom RE Jr; University of California at Los Angeles Ocular Inflammatory; Disease Center, Department of Ophthalmology, University of; California at Los Angeles School of Medicine, USA.
- Testing a model: effects of pain on immunity in HIV+ and HIV- participants.
- Sch Inq Nurs Pract. 1998 Fall;12(3):191-214; discussion 215-20. Unique Identifier : AIDSLINE MED/99205805
- Eller LS; Rutgers University, College of Nursing, Newark, NJ 07102, USA.
- In this study, the cold pressor test (CPT) was used to test a model of the effects of acute pain on 10 HIV+ and 10 HIV- adults. Participants were exposed to the CPT for a maximum of 5 minutes. Blood samples were collected immediately before, immediately after, and 1 hour after the CPT. Variables included immune measur
- Research of antigen and antibodies from retroviruses, CMV and HBV among prisoners of the penitentiary complex of the region of Campinas, SP, Brazil.
- Rev Inst Med Trop Sao Paulo. 1998 Jul-Aug;40(4):209-13. Unique Identifier : AIDSLINE MED/99093712
- Osti NM; de Castro AF; Ricci LC; Department of Clinical and Toxicological Analysis, College of; Medical Sciences, Catholic University of Campinas (PUCAMPP); Campinas, SP, Brazil.
- Some viruses of the families Retroviridae, such as Human T Lymphotropic Virus (HTLV); Herpesviridae as the Cytomegalovirus ( CMV ) and Hepadnaviridae such as the Hepatitis B Virus (HBV) are liable to be co-transmitted with the Human Immunodeficiency Virus (HIV). S
- A 3-year follow-up of a Brazilian AIDS patient with protracted diarrhea caused by Enterocytozoon bieneusi.
- Rev Inst Med Trop Sao Paulo. 1998 Jul-Aug;40(4):215-8. Unique Identifier : AIDSLINE MED/99093713
- Brasil P; de Paiva DD; de Lima DB; da Silva EJ; Peralta JM; da Silva AJ; Sodre FC; Villela EV; Moura H; Departamento de Parasitologia e Patologia, Faculdade de Ciencias; Medicas (FCM), Universidade do Estado do Rio de Janeiro (UERJ),; Brazil.
- Enterocytozoon bieneusi is the most prevalent microsporidian parasite that causes gastrointestinal infection in persons with AIDS. Microsporidia are increasingly recognized as important opportunistic pathogens all over the world but in Brazil only few cases have been reported due e
- Salmonella-S. mansoni association in patients with acquired immunodeficiency syndrome.
- Rev Inst Med Trop Sao Paulo. 1998 Jul-Aug;40(4):233-5. Unique Identifier : AIDSLINE MED/99093716
- Lambertucci JR; Rayes AA; Gerspacher-Lara R; Departamento de Clinica Medica, Faculdade de Medicina de UFMG,; Belo Horizonte, MG, Brasil. lamber@net.em.com.br
- Two young men with Salmonella bacteraemia, active schistosomiasis and the acquired immunodeficiency syndrome are reported. The clinical presentation comprised nonspecific signs and symptoms, such as fatigue, malaise, weight loss, diarrhoea, prolonged fever, and hepatosplenomegaly. In one patient, liver biopsy showed p
- Vertical transmission of HTLV-I/II: a review.
- Rev Inst Med Trop Sao Paulo. 1998 Jul-Aug;40(4):245-51. Unique Identifier : AIDSLINE MED/99093719
- Bittencourt AL; Faculdade de Medicina, Universidade Federal da Bahia, Brasil.; achilea@svn.com.br
- The vertical transmission of the human T-cell lymphotropic virus type I (HTLV-I) occurs predominantly through breast-feeding. Since some bottle-fed children born to carrier mothers still remain seropositive with a frequency that varies from 3.3% to 12.8%, an alternative pathway of vertical transmission must be conside
- Diverse T-cell receptor CDR3 length patterns in human CD4+ and CD8+ T lymphocytes from newborns and adults.
- Scand J Immunol. 1999 Feb;49(2):149-54. Unique Identifier : AIDSLINE MED/99173313
- Halapi E; Jeddi-Tehrani M; Blucher A; Andersson R; Rossi P; Wigzell H; Grunewald J; Microbiology and Tumorbiology Center, Karolinska Institute,; Stockholm, Sweden.
- T cells are essential in the initiation and maintenance of immune responses. Specific interaction between T cells and a presumptive antigen occurs through recognition of an MHC-peptide complex by the T-cell receptor (TCR). The complementarity-determining region (CDR) 3 of the TCR has direct contact with the peptide. H
- Normal T-helper 1/T-helper 2 balance in peripheral blood of coeliac disease patients.
- Scand J Immunol. 1999 Feb;49(2):197-202. Unique Identifier : AIDSLINE MED/99173320
- Kerttula TO; Collin P; Maki M; Hurme M; Department of Clinical Microbiology, Tampere University Hospital,; Finland.
- Activated T cells, with their secretion of cytokines, probably play an important role in the pathogenesis of mucosal lesions in coeliac disease (COD) and the prominence of a T-helper (Th)1-type cytokine pattern has been reported. As the process of immunological activation in the jejunal mucosa in active CoD has been s
- Relationship between interleukin-5 production and variations in eosinophil counts during HIV infection in West Africa: influence of Mycobacterium tuberculosis infection.
- Scand J Immunol. 1999 Feb;49(2):203-9. Unique Identifier : AIDSLINE MED/99173321
- Diagbouga S; Aldebert D; Fumoux F; Capron M; Ledru E; Centre MURAZ, Organisation de Coordination et de Cooperation; pour la lutte contre les Grandes endemies, Burkina Faso, West; Africa.
- Eosinophils are important effectors of the non-specific immune response and we studied whether perturbations in the production of the type 2 cytokine, interleukin-5 (IL-5), could account for the variations in eosinophil counts observed in human immunodeficiency virus (HIV) infection. HIV-infected patients without helm
- Administration of interleukin-12 prevents mite Der p 1 allergen-IgE antibody production and airway eosinophil infiltration in an animal model of airway inflammation.
- Scand J Immunol. 1999 Mar;49(3):229-36. Unique Identifier : AIDSLINE MED/99200784
- Lee YL; Fu CL; Ye YL; Chiang BL; Graduate Institute of Microbiology, College of Medicine, National; Taiwan University, Taipei, Republic of China.
- The aim of the present study was to examine the in vivo effect of interleukin (IL)-12 on a murine model of asthma induced by Dermatophagoides pteronyssinus-derived Der p 1 allergen. C57BL/6 mice immunized with Der p 1 allergen adsorbed to alum/pertussis toxin developed a T-helper type 2 (Th2)-dominant immune response
- Characterization of two infectious mouse mammary tumour viruses: superantigenicity and tumorigenicity.
- Scand J Immunol. 1999 Mar;49(3):269-77. Unique Identifier : AIDSLINE MED/99200789
- Buggiano V; Goldman A; Nepomnaschy I; Bekinschtein P; Berguer P; Lombardi G; Deroche A; Francisco MV; Piazzon I; Division Medicina Experimental, Instituto de Investigaciones; Hematologicas, Academia Nacional de Medicina, Buenos Aires,; Argentina.
- Mouse mammary tumour virus (MMTV) is a type B retrovirus that causes mammary tumours in susceptible mice. MMTV encodes a superantigen (SAg) that has the property of stimulating T-cell populations expressing a particular variable region of the T-cell receptor (TCR) beta chain (Vbeta) and needs to be presented in the co
- The effects of CD40 ligation on peripheral blood mononuclear cell interleukin-12 and interleukin-15 production and on monocyte CD14 surface antigen expression in human immunodeficiency virus-positive patients.
- Scand J Immunol. 1999 Mar;49(3):286-92. Unique Identifier : AIDSLINE MED/99200791
- Zanussi S; D'Andrea M; Simonelli C; Trabattoni D; Bortolin MT; Caggiari L; Tirelli U; Clerici M; De Paoli P; Department of Microbiology/Immunology/Virology, Centro di; Riferimento Oncologico, Aviano, Italy.
- Human immunodeficiency virus (HIV) infection causes dysregulation of surface phenotype, of accessory function and of cytokine production from peripheral blood mononuclear cells (PBMCs). As CD40 ligation induces several functional activities in these cells, this stimulation may partially mimic the situation occurring i
- Increased CD4+ T-lymphocyte senescence fraction in advanced human immunodeficiency virus type 1 infection.
- Scand J Immunol. 1999 Mar;49(3):302-6. Unique Identifier : AIDSLINE MED/99200793
- Nichols WS; Schneider S; Chan RC; Farthing CF; Daar ES; Department of Pathology and Laboratory Medicine, Cedars Sinai; Medical Center, Los Angeles, California 90048, USA.
- Human immunodeficiency virus type 1 (HIV-1) infection is accompanied by peripheral CD4+ T-cell losses. CD4+ T-cell numbers often increase during antiviral treatment of acquired immune deficiency syndrome (AIDS), however, alterations in the CD4+ T-cell repertoire have not been completely corrected for these patients. S
- Leishmania donovani infection of a susceptible host results in CD4+ T-cell apoptosis and decreased Th1 cytokine production.
- Unique Identifier : AIDSLINE MED/99200794
- Nabel to head NIH Vaccine Research Center [news]
- Science. 1999 Mar 19;283(5409):1829;1831. Unique Identifier : AIDSLINE MED/99217430
- Cohen J
- Demographic changes in tuberculosis: high risk groups.
- South Med J. 1999 Mar;92(3):280-4. Unique Identifier : AIDSLINE MED/99192080
- Mehta JB; Roy TM; Hughes SK; Byrd RP Jr; Harvill LM; Department of Internal Medicine, James H. Quillen College of; Medicine, East Tennessee State University, Northeast Tennessee; Regional Health Office, Johnson City 37614-0622, USA.
- We conducted a statistical analysis of all verifiable tuberculosis (TB) cases in Tennessee from 1990 through 1996 to determine the demographic changes in TB. We studied variables, including age, sex, race, site of the disease, and possible impact of known risk factors such as human immunodeficiency virus (HIV) infecti
- Sexual experiences and condom use of heterosexual, low-income African American and Hispanic youth practicing relative monogamy, serial monogamy, and nonmonogamy.
- Sex Transm Dis. 1999 Jan;26(1):17-25. Unique Identifier : AIDSLINE MED/99114851
- Norris AE; Ford K; School of Nursing, Boston College, Chestnut Hill, Massachusetts; 02167, USA.
- BACKGROUND AND OBJECTIVES: To describe (a) demographic characteristics, (b) sexual history, (c) perceived HIV susceptibility, and (d) current sexual behavior, condom use, and alcohol and marijuana use of heterosexual, low-income African American and Hispanic youth categorized as relatively monogamous (n = 577), serial
- The etiology of genital ulcer disease by multiplex polymerase chain reaction and relationship to HIV infection among patients attending sexually transmitted disease clinics in Pune, India.
- Sex Transm Dis. 1999 Jan;26(1):55-62. Unique Identifier : AIDSLINE MED/99114856
- Risbud A; Chan-Tack K; Gadkari D; Gangakhedkar RR; Shepherd ME; Bollinger R; Mehendale S; Gaydos C; Divekar A; Rompalo A; Quinn TC; National AIDS Research Institute, Pune, India.
- OBJECTIVES: To determine the etiology of genital ulcer disease (GUD) among patients attending sexually transmitted disease (STD) clinics in Pune, India , and to examine the relationship to HIV infection and compare the clinical diagnosis of GUD with the results of a multiplex polymer
- Etiology of genital ulcer disease and its relationship to HIV infection [editorial]
- Sex Transm Dis. 1999 Jan;26(1):63-5. Unique Identifier : AIDSLINE MED/99114857
- Morse SA
- Effect of the antioxidants selenium and beta-carotene on HIV-related endothelium dysfunction.
- Thromb Haemost. 1998 Dec;80(6):1015-7. Unique Identifier : AIDSLINE MED/99084521
- Constans J; Seigneur M; Blann AD; Renard M; Resplandy F; Amiral J; Guerin V; Boisseau MR; Conri C; Service de Medecine Interne et Pathologie Vasculaire, Hopital; St. Andre, Bordeaux, France.
- Patients infected with HIV are at increased risk of atherosclerosis, and have evidence of endothelium dysfunction. The hypothesis was tested that HIV-related endothelium dysfunction is related to loss of antioxidants. This was done by the supplementation of the antioxidants selenium and beta-carotene. We supplemented
- Retrospective neuropathological review of prion disease in UK haemophilic patients.
- Thromb Haemost. 1998 Dec;80(6):909-11. Unique Identifier : AIDSLINE MED/99084504
- Lee CA; Ironside JW; Bell JE; Giangrande P; Ludlam C; Esiri MM; McLaughlin JE; Royal Free Hospital, London, UK.
- In 1996, the CJD surveillance unit in Edinburgh, UK described nvCJD which was thought to be the human equivalent of bovine spongiform encephalopathy (BSE). The identification of prion protein in the tonsil of an affected individual has raised the question of transmission of nvCJD via blood products. This study examine
- The role of anchor residues in the binding of peptides to HLA-A*1101 molecules.
- Tissue Antigens. 1998 Dec;52(6):501-9. Unique Identifier : AIDSLINE MED/99110139
- Chujoh Y; Sobao Y; Miwa K; Kaneko Y; Takiguchi M; Department of Tumor Biology, Institute of Medical Science,; University of Tokyo, Japan.
- The binding of 136 8- to 12-mer peptides carrying anchor residues at position 2 (P2) and the C-terminus to HLA-A*1101 molecules was analyzed by a stabilization assay using RMA-S transfectants expressing HLA-A*1101 and human beta2-microglobulin. 72.1% of these peptides bound to HLA-A*1101 molecules. Two known HLA-All-r
- Staphylococcal enterotoxin-A directly stimulates signal transduction and interferon-gamma production in psoriatic T-cell lines.
- Tissue Antigens. 1998 Dec;52(6):530-8. Unique Identifier : AIDSLINE MED/99110142
- Nielsen MB; Odum N; Gerwien J; Svejgaard A; Bendtzen K; Bregentholt S; Ropke C; Geisler C; Dohlsten M; Kaltoft K; Institute for Microbiology and Immunology, University of; Copenhagen, Denmark.
- Bacterial superantigens such as staphylococcal enterotoxin-A (SEA) have been implicated in the pathogenesis of psoriasis vulgaris. Major histocompatibility complex (MHC) class II molecules are high affinity receptors for SEA, and T cells found in psoriatic skin lesions express high levels of MHC class II. Here we addr
- Hydrocortisone activation of human herpesvirus 8 viral DNA replication and gene expression in vitro.
- Transplantation. 1999 Mar 15;67(5):648-52. Unique Identifier : AIDSLINE MED/99194181
- Hudnall SD; Rady PL; Tyring SK; Fish JC; Department of Pathology, University of Texas Medical Branch,; Galveston 77555-0741, USA. shudnall@utmb.edu
- BACKGROUND: Patients undergoing chronic steroid therapy for organ transplantation are at increased risk for development of human herpes virus 8(HHV-8)-associated Kaposi s sarcoma (KS). It has also been reported that following steroid withdrawal, KS lesions often undergo partial or complete regression. METHODS: We have
- Temporal sequence of transcription of perforin, Fas ligand, and tumor necrosis factor-alpha genes in rejecting skin allografts.
- Transplantation. 1999 Mar 15;67(5):672-80. Unique Identifier : AIDSLINE MED/99194185
- Borson ND; Strausbauch MA; Kennedy RB; Oda RP; Landers JP; Wettstein PJ; Department of Immunology, Mayo Foundation, Rochester, Minnesota; 55905, USA.
- BACKGROUND: Perforin, Fas ligand (FasL), and tumor necrosis factor-alpha (TNF-alpha) have been implicated in cytolytic T lymphocyte (CTL) effector function. However, the relative roles of these effector molecules in allograft rejection are unclear, and there has been no rigorous quantitation of transcription of the re
- The immunosuppressive agent mycophenolate mofetil markedly potentiates the activity of lobucavir [1R(1alpha,2beta,3alpha)]-9-[2,3-bis(hydroxymethyl)cyclobutyl]gua- nine against different herpes viruses.
- Transplantation. 1999 Mar 15;67(5):760-4. Unique Identifier : AIDSLINE MED/99194201
- Neyts J; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
- BACKGROUND: Mycophenolate mofetil (MMF) has been approved as an immunosuppressive agent in kidney transplant recipients and may thus be used concomitantly with antiherpetic agents, the latter for the treatment of intercurrent herpesvirus infections. The parent compound of MMF, mycophenolic acid (MPA), is a potent inhi
- FTY720, a novel immunosuppressant, prolongs rat skin allograft survival by decreasing T-cell infiltration into grafts.
- Transplant Proc. 1999 Feb-Mar;31(1-2):1227-9. Unique Identifier : AIDSLINE MED/99183117
- Yanagawa Y; Hoshino Y; Kataoka H; Kawaguchi T; Ohtsuki M; Sugahara K; Chiba K; Tokyo Laboratories, Yoshitomi Pharmaceutical Industries, Saitama,; Japan.
- Immune nonresponsiveness to cardiac allografts by intrathymic inoculation of donor class I allopeptides is associated with high levels of transcripts for Th2 cytokines in the graft.
- Transplant Proc. 1999 Feb-Mar;31(1-2):123-4. Unique Identifier : AIDSLINE MED/99182608
- Shirwan H; Barwari L; Khan NS; Institute for Cellular Therapeutics, Allegheny University of the; Health Sciences, Philadelphia, Pennsylvania 19102, USA.
- Mycophenolate mofetil impairs transendothelial migration of allogeneic CD4 and CD8 T-cells.
- Transplant Proc. 1999 Feb-Mar;31(1-2):1250-2. Unique Identifier : AIDSLINE MED/99183128
- Blaheta RA; Leckel K; Wittig B; Zenker D; Oppermann E; Harder S; Scholz M; Weber S; Encke A; Markus BH; Department of General Surgery, Johann Wolfgang Goethe-University,; Frankfurt am Main, Germany.
- In vivo differentiation of alloreactive CD8+ T cells after murine cardiac allograft transplantation.
- Transplant Proc. 1999 Feb-Mar;31(1-2):130. Unique Identifier : AIDSLINE MED/99182611
- Gilot BJ; Hara M; Jones ND; van Maurik A; Hadjianastassiou V; Morris PJ; Wood KJ; Nuffield Department of Surgery, University of Oxford, John; Radcliffe Hospital, Headington, United Kingdom.
- Two types of CMV-specific memory responses in lung transplant recipients.
- Transplant Proc. 1999 Feb-Mar;31(1-2):173-4. Unique Identifier : AIDSLINE MED/99182632
- Zeevi A; Spichty K; Banas R; Morel P; Iacono A; Dauber J; Yousem S; Pham S; Keenan R; Duquesnoy R; Griffith B; Thomas E. Starzl Transplantation Institute, Pittsburgh,; Pennsylvania, USA. zeevi+@pitt.edu
- P-glycoprotein expression in patients before and after kidney transplantation.
- Transplant Proc. 1999 Feb-Mar;31(1-2):299-300. Unique Identifier : AIDSLINE MED/99182684
- Melk A; Daniel V; Weimer R; Mandelbaum A; Wiesel M; Staehler G; Opelz G; Department of Transplantation Immunology, University of; Heidelberg, Germany.
- Complete reversal of acute rejection episodes after syngeneic retransplantation is associated with a TH1/TH2 shift.
- Transplant Proc. 1999 Feb-Mar;31(1-2):340-1. Unique Identifier : AIDSLINE MED/99182703
- Tullius SG; Graser E; Nieminen M; Reutzel-Selke A; Jonas S; Bechstein WO; Volk HD; Neuhaus P; Department of Surgery and Medical Immunology, Charite-Virchow; Clinic, Berlin, Germany.
- Mechanism of liver allograft rejection: indirect allorecognition.
- Transplant Proc. 1999 Feb-Mar;31(1-2):409-10. Unique Identifier : AIDSLINE MED/99182734
- Renna-Molajoni E; Cinti P; Elia L; Orlandini AM; Cocciolo P; Molajoni J; Ho E; Suciu-Foca N; Cortesini R; ISMEDA-CNR, Italy.
- Influence of Th1 and Th2 cytokine patterns on graft acceptance in pediatric liver transplantation.
- Transplant Proc. 1999 Feb-Mar;31(1-2):465-6. Unique Identifier : AIDSLINE MED/99182761
- Ganschow R; Nolkemper D; Hoffmann T; Gieseking J; Rogiers X; Broelsch CE; Burdelski M; Department of Pediatrics, University of Hamburg, Germany.
- Apoptosis of alloreactive T cells in liver allografts during tolerance induction.
- Transplant Proc. 1999 Feb-Mar;31(1-2):474. Unique Identifier : AIDSLINE MED/99182765
- Meyer D; Thorwarth M; Otto C; Gassel HJ; Timmermann W; Ulrichs K; Thiede A; Department of Surgery, University of Wurzburg, Germany.
- Developing strategies for prevention and treatment of recurrent HBV in liver transplantation.
- Transplant Proc. 1999 Feb-Mar;31(1-2):485-6. Unique Identifier : AIDSLINE MED/99182771
- Nery JR; Weppler D; Lavandera R; Nery Avila C; Magill A; Rodriguez M; Reddy KR; Schiff E; Tzakis AG; Division of Liver/GI Transplantation, University of Miami School; of Medicine, Florida 33136, USA.
- Natural history of Epstein-Barr viral load in peripheral blood of pediatric liver transplant recipients during treatment for posttransplant lymphoproliferative disorder.
- Transplant Proc. 1999 Feb-Mar;31(1-2):488-9. Unique Identifier : AIDSLINE MED/99182773
- Cacciarelli TV; Reyes J; Mazariegos GV; Sigurdsson L; Rowe DT; Fung JJ; Green M; Children's Hospital of Pittsburgh, PA 15213, USA.
- CD30+ and CD27- lymphocytes in liver transplant: Th2 cytokine secretion.
- Transplant Proc. 1999 Feb-Mar;31(1-2):516-8. Unique Identifier : AIDSLINE MED/99182785
- Minguela A; Marin L; Torio A; Muro M; Ontanon J; Alemany JM; Sanchez-Bueno F; Parrilla P; Alvarez-Lopez MR; Immunology Section, University Hospital Virgen de la Arrixaca,; Murcia, Spain.
- Implication of Th1, Th2, and Th3 cytokines in liver graft acceptance.
- Transplant Proc. 1999 Feb-Mar;31(1-2):519-20. Unique Identifier : AIDSLINE MED/99182786
- Minguela A; Torio A; Marin L; Sanchez-Bueno F; Garcia-Alonso AM; Ontanon J; Parrilla P; Alvarez-Lopez MR; Immunology Section, University Hospital Virgen de la Arrixaca,; Murcia, Spain.
- Lamivudine prophylaxis in liver transplantation for hepatitis B in Asians.
- Transplant Proc. 1999 Feb-Mar;31(1-2):535-6. Unique Identifier : AIDSLINE MED/99182793
- Lo CM; Fan ST; Lai CL; Liu CL; Yuen MF; Ng IO; Wong J; Department of Surgery, University of Hong Kong Medical Center,; Queen Mary Hospital, China.
- Good results of lamivudine in hepatitis B surface antigen-positive patients with active viral replication before liver transplantation.
- Transplant Proc. 1999 Feb-Mar;31(1-2):554-5. Unique Identifier : AIDSLINE MED/99182803
- Gugenheim J; Baldini E; Ouzan D; Sowka P; Mouiel J; Service de Chirurgie Digestive, Universite de Sophia Antipolis,; Nice, France.
- Analysis of the in vivo and in vitro response of human T cells to porcine islets.
- Transplant Proc. 1999 Feb-Mar;31(1-2):648-9. Unique Identifier : AIDSLINE MED/99182848
- Olack B; Poindexter N; Swanson C; Steward N; Howard T; Mohanakumar T; Department of Surgery, Washington University School of Medicine,; St. Louis, MO, USA.
- The role of atypical T cells and NK cells in inhibiting primary engraftment of xenogeneic donor rat bone marrow cells.
- Transplant Proc. 1999 Feb-Mar;31(1-2):683. Unique Identifier : AIDSLINE MED/99182863
- Cooke DT; Nikolic B; Sykes M; Transplantation Biology Research Center, Massachusetts General; Hospital, Harvard Medical School, Boston, USA.
- Increased IL-4 production and decreased CD40L expression by newborn T cells contribute to transplantation tolerance.
- Transplant Proc. 1999 Feb-Mar;31(1-2):782-3. Unique Identifier : AIDSLINE MED/99182902
- Donckier V; Flamand V; Abramowicz D; Goldman M; Laboratory of Experimental Immunology, Universite Libre de; Bruxelles, Belgium.
- Thymic-independent peripheral tolerance.
- Transplant Proc. 1999 Feb-Mar;31(1-2):802-3. Unique Identifier : AIDSLINE MED/99182915
- Chen ZK; Metcalfe SM; Department of Surgery, Addenbrooke's Hospital, Cambridge; University, United Kingdom. zc104@hermes.cam.ac.uk
- Role of graft cytokine expression in the tolerogenicity of neonatal skin allografts.
- Transplant Proc. 1999 Feb-Mar;31(1-2):813. Unique Identifier : AIDSLINE MED/99182921
- Gozzo J; De Fazio S; Bouve College of Pharmacy and Health Sciences, Northeastern; University, Boston, MA 02115, USA.
- Indirect allorecognition is involved in both acute and chronic allograft rejection.
- Transplant Proc. 1999 Feb-Mar;31(1-2):842-3. Unique Identifier : AIDSLINE MED/99182935
- Fluck N; Witzke O; Morris PJ; Wood KJ; Nuffield Department of Surgery, University of Oxford, John; Radcliffe Hospital, Headington, United Kingdom.
- Study of donor-specific antigens in inducing tolerance and enhancing graft survival.
- Transplant Proc. 1999 Feb-Mar;31(1-2):846. Unique Identifier : AIDSLINE MED/99182938
- Lu YP; Wang J; Yang YR; Tang XD; Institute of Organ Transplantation, 1st University Hospital, West; China University of Medical Sciences, Chengdu/Sichuan, China.
- CD8+ cytotoxic T lymphocytes are involved in inducing medial cell dropout via apoptosis in mouse aortic allografts.
- Transplant Proc. 1999 Feb-Mar;31(1-2):865-6. Unique Identifier : AIDSLINE MED/99182946
- O'Neill JL; Lee TD; Hirsch GM; Dalhousie University, Halifax, Nova Scotia, Canada.
- Induction and maintenance of tolerance by CTLA-4IG in rat small bowel allografts.
- Transplant Proc. 1999 Feb-Mar;31(1-2):878-81. Unique Identifier : AIDSLINE MED/99182954
- Tarumi K; Yagihashi A; Tsuruma T; Koide S; Sasaki K; Hirata K; First Department of Surgery, Sapporo Medical University School of; Medicine, Japan.
- Rejection of discordant skin xenografts by CD4- CD8- TCR alpha beta+ cells in CD4- and CD8-deficient mice.
- Transplant Proc. 1999 Feb-Mar;31(1-2):890-1. Unique Identifier : AIDSLINE MED/99182960
- Umesue M; Mayumi H; Kong YY; Omoto K; Muranaka H; Nakanishi R; Kohno H; Yasumoto K; Kishihara K; Nomoto K; Second Department of Surgery, University of Occupational and; Environmental Health, Fukuoka, Japan.
- Involvement of Th1 subset in allogeneic keratinocyte rejection.
- Transplant Proc. 1999 Feb-Mar;31(1-2):896. Unique Identifier : AIDSLINE MED/99182963
- Rouabhia M; Roy R; Department of Surgery, Laval University, Quebec, Canada.
- In vivo cytokine production by allospecific CD8+ transgenic T cells after heart transplantation.
- Transplant Proc. 1999 Feb-Mar;31(1-2):91. Unique Identifier : AIDSLINE MED/99182590
- Hara M; Gilot BJ; Jones ND; Van Maurik A; Barbara JA; Morris PJ; Wood KJ; Nuffield Department of Surgery, University of Oxford, John; Radcliffe Hospital, England.
- Transplantation-associated Kaposi's sarcoma: herpesvirus 8 transmission through renal allografts.
- Transplant Proc. 1999 Feb-Mar;31(1-2):922-3. Unique Identifier : AIDSLINE MED/99182975
- Regamey N; Tamm M; Binet I; Thiel G; Erb P; Cathomas G; Institute for Medical Microbiology, University of Basel,; Switzerland.
- Preferred T-cell receptor V beta usage in the xenogeneic human antiporcine cytolytic response.
- Transplant Proc. 1999 Feb-Mar;31(1-2):930-1. Unique Identifier : AIDSLINE MED/99182980
- Chen MC; Xu XC; Mohanakumar T; Department of Surgery, Washington University School of Medicine,; St Louis, MO 63110, USA.
- Rejection of hamster cardiac xenografts by rat CD4+ or CD8+ T cells.
- Transplant Proc. 1999 Feb-Mar;31(1-2):959-60. Unique Identifier : AIDSLINE MED/99182995
- Lin Y; Soares MP; Sato K; Takigami K; Csizmadia E; Anrather J; Bach FH; Immunobiology Research Center, Beth Israel Deaconess Medical; Center, Harvard Medical School, Boston, MA 02215, USA.; ylin@bidmc.harvard.edu
- Immunohistochemical studies of productive rhesus cytomegalovirus infection in rhesus monkeys (Macaca mulatta) infected with simian immunodeficiency virus.
- Vet Pathol. 1999 Jan;36(1):51-6. Unique Identifier : AIDSLINE MED/99118729
- Kuhn EM; Stolte N; Matz-Rensing K; Mach M; Stahl-Henning C; Hunsmann G; Kaup FJ; German Primate Centre, Gottingen. evakuhn@bprc.nl
- In humans infected with the human immunodeficiency virus (HIV), clinical disease due to human cytomegalovirus (HCMV) infection is one of the AIDS-defining diseases; HCMV is the most common opportunistic infection found postmortem. Histologically, the typical lesions are characteriz
- Immune response to the immunodominant epitope of mouse hepatitis virus is polyclonal, but functionally monospecific in C57Bl/6 mice.
- Virology. 1999 Mar 1;255(1):106-16. Unique Identifier : AIDSLINE MED/99160761
- Pewe L; Perlman S; Department of Pediatrics, University of Iowa, Iowa City, Iowa; 52242, USA.
- Mutations in an immunodominant CD8 CTL epitope (S-510-518) are selected in mice persistently infected with the neurotropic JHM strain of mouse hepatitis virus. These mutations abrogate recognition by T cells harvested from the infected CNS in direct ex vivo cytotoxicity assays. Previous reports have suggested that, in
- Interactions between Tat and TAR and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins T2a or T2b.
- Virology. 1999 Mar 1;255(1):182-9. Unique Identifier : AIDSLINE MED/99160768
- Wimmer J; Fujinaga K; Taube R; Cujec TP; Zhu Y; Peng J; Price DH; Peterlin BM; Department of Medicine, University of California at San; Francisco, San Francisco, California 94143-0703, USA.
- The transcriptional transactivator (Tat) from the human immunodeficiency virus (HIV) does not function efficiently in Chinese hamster ovary (CHO) cells. Only somatic cell hybrids between CHO and human cells and CHO cells containing human chromosome 12 (CHO12) support high levels of Tat transactivation. This restrictio
- Tagging the human immunodeficiency virus gag protein with green fluorescent protein. Minimal evidence for colocalisation with actin.
- Virology. 1999 Mar 1;255(1):20-5. Unique Identifier : AIDSLINE MED/99160752
- Perrin-Tricaud C; Davoust J; Jones IM; NERC Institute of Virology, Mansfield Road, Oxford, OX1 3SR, UK.
- The assembly and budding of human immunodeficiency virus type 1, encoded solely in the Gag protein precursor Pr55Gag, occur at the plasma membrane of infected cells. However, little is known about the routing of the Gag molecule from its site of synthesis in the cytoplasm to the site of budding, with past studies sugg
- Phenotypic and functional characterization of CD8(+) T cell clones specific for a mouse cytomegalovirus epitope.
- Virology. 1999 Mar 1;255(1):40-9. Unique Identifier : AIDSLINE MED/99160755
- Fernandez JA; Zavala F; Tsuji M; Department of Medical and Molecular Parasitology, New York; University School of Medicine, New York, New York 10010, USA.
- A series of CD8(+) T cell clones, specific for the IE1 epitope YPHFMPTNL, of the immediate-early protein 1 of the murine cytomegalovirus (MCMV) were generated in order to determine their protective activity against this infection and correlate their phenotypic markers with antivira
- A novel Vpr peptide interactor fused to integrase (IN) restores integration activity to IN-defective HIV-1 virions.
- Virology. 1999 Mar 1;255(1):77-85. Unique Identifier : AIDSLINE MED/99160758
- Kulkosky J; BouHamdan M; Geist A; Pomerantz RJ; Center for Human Virology, Jefferson Medical College, Thomas; Jefferson University, Philadelphia, Pennsylvania 19107, USA.; kulkosok1@jeflin.tju.edu
- A novel approach to complement human immunodeficiency virus type I (HIV-1) integrase (IN)-defective virions has been identified. The approach involves fusion of a 23-amino-acid stretch to the N-terminus of wild-type IN and coexpression of this chimera with the IN-defective proviral template in virus producing cells. T
- [The principles of pre-epidemic diagnosis in the epidemiological surveillance system for HIV infection]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):10-1. Unique Identifier : AIDSLINE MED/99195917
- Borovskii IV; Goliusov AT; Baitugaeva SA; Shapovalov SV; Ministry of Public Health of the Russian Federation, Moscow.
- The problem of the general introduction of the principles of the pre-epidemic diagnostics of HIV infection was discussed. These principles should be based on the observation of model infections (viral hepatitides B, C, D), multipurpose serological monitoring and sociological methods aimed at obtaining the necessary
- [The legal status of Russian HIV-infected persons]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):100-2. Unique Identifier : AIDSLINE MED/99195960
- D'iachenko AP; Non-government organization We and You, Moscow, Russia.
- According to the data, presented by the author and based on the study of opinions expressed by HIV-infected persons, 80% of them are subjected to discrimination. The article deals with the problem of the legal protection of HIV-infected persons in the Russian Federation. Additions and changes in the current legislatio
- [The prostitution situation in a number of cities of Russia, Ukraine and Byelarus]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):102-4. Unique Identifier : AIDSLINE MED/99195961
- Lakhumalani V; Social Development and Health Department, British Council,; Calcutta, India.
- The analytical study indicating that 25% of prostitutes use drugs by intravenous injection is presented. As determined in this study, prostitutes face the double danger of being infected with HIV (they undergo treatment for drug addiction and sexually transmitted diseases). The conclusion has been made that no educati
- [HIV infection: the psychological indices at different stages of the disease]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):104-6. Unique Identifier : AIDSLINE MED/99195962
- Uliukin IM; Voronin EE; Central Clinical Infectious Hospital, Ust-Izhora, St. Petersburg,; Russia.
- The pronounced forms of depression and the levels of neuro-psychical adaptation and subjective control (attitude to the disease) were studied in 27 patients with HIV infection. 14 patients were at stage A, 8 patients were at stage B and 5 patients were at stage C of the CDC classification (1994). Starting from the ear
- [A decrease in harm: a new concept for Russian public health]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):107-8. Unique Identifier : AIDSLINE MED/99195963
- Burrows D; Sarankov Iu; Medecins Sans Frontieres, Moscow, Russia.
- The main principles of the concept of the decrease of harm , realized in many countries of the world, are presented and the expediency of using this concept in Russia is substantiated. The beginning of the realization of the Project Decrease of Harm: the Russian Federation , aime
- [The spread of AIDS among homosexuals in the Commonwealth of Independent States and Baltic countries]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):11-3. Unique Identifier : AIDSLINE MED/99195918
- Mekkelsen H; WHO Regional Office for Europa, Copenhagen, Denmark.
- The data on the spread of AIDS among homosexuals (HS) are presented. Studies carried out in the CIS and Baltic countries in 1995-1997 revealed that this group formed a highly favorable environment for the spread of HIV infection and sexually transmitted diseases (STD). The discrepancy between the real number of HIV ca
- [The educating and informing of the population on HIV/AIDS problems in the Republic of Byelarus]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):110-1. Unique Identifier : AIDSLINE MED/99195965
- Bykova VM; Center for Prophylaxis of AIDS, Minsk, Belarus.
- Data on the spread of knowledge and information among the population of the Republic of Belarus , mainly young people aged 14-20 years as the most susceptible group, are presented. Sociological questioning carried out among students of institutions of higher education indicated tha
- [Children, adolescents and HIV infection]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):112-3. Unique Identifier : AIDSLINE MED/99195966
- Kuznetsova VV; City Center for Prophylaxis and Control of AIDS, Moscow, Russia.
- The analysis of the occurrence of HIV infection in adults, children and adolescents under 18 years of age on the basis of statistical data by February 1, 1997, is presented. The total number HIV-infected persons registered by this date was 6,232; among them 902 (14.5%) were children and adolescents. 267 children were
- [The role of educational programs on the prevention of HIV infection and the development of a healthy life style for adolescents]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):113-4. Unique Identifier : AIDSLINE MED/99195967
- Mamchik TA; Kudriavtseva ND; Zemlianskaia NP; Shipitsyna LV; Regional Center for Prophylaxis and Control of AIDS and; Infectious Diseases, Voronezh, Russia.
- On the basis of answers to questionnaires more active use of local TV channels for educational work in the dissemination of knowledge on the prophylaxis of HIV infection is recommended. It is advisable to enlist the cooperation of school psychologists in the work on the social adaptation of adolescents with a view to
- [The role of public organizations in the prevention of HIV infection in Russia]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):114-6. Unique Identifier : AIDSLINE MED/99195968
- Dement'eva LA; Ministry of Public Health, Russian Federation, Moscow, Russia.
- The problem of the role of public organizations in the prevention of the spread of HIV infection in Russia is discussed. The correctly chosen strategy of cooperation between governmental structures and non-governmental public associations corresponds to the modern principles of sta
- [A comparative study of the level of knowledge of schoolchildren about HIV infection and AIDS]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):116-7. Unique Identifier : AIDSLINE MED/99195969
- Kopnina EO; Al'tova EE; Zaitseva NN; Ivanova NI; Matveeva EM; Myzina OI; Research Institute of Epidemiology and Microbiology, Nizhny; Novgorod, Russia.
- The comparative study of the level knowledge on HIV infection and AIDS among school children was carried out. The prophylactic work among school children yielded positive results, which was statistically confirmed by the analysis of answers to questionnaires, distributed before and after lectures.
- [The clean syringe and HIV infection. A clean syringe can be obtained by any drug addict in a bus stationed in places of active drug trading]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):118-9. Unique Identifier : AIDSLINE MED/99195970
- Ostrovskii DV; Charitable Fund Vozvrashchenie, St.Petersburg, Russia.
- The results of the work on the Program Bus supported by the Charitable Fund Vozvrashchenie and the French organization Doctors of the World [correction of Word] are presented. The Program Bus , in contrast to a number of other programs aimed at the decrease of harm , extended the project by providing the possibi
- [Work with youth--the basis of educational programs aimed at the prevention of HIV infection]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):119-20. Unique Identifier : AIDSLINE MED/99195971
- Agafonova OV; Borovskii IV; Demchenko VV; Pavlova AM; Filatova IM; Regional Center for Prophylaxis and Control of AIDS and; Infectious Diseases, Omsk, Russia.
- During the recent 10 years, 1987-1997, syphilis morbidity was found to increase 60-fold in Omsk Province. In 1997 adolescents constituted 6.0% in the structure of persons who contacted the disease. In this year more than 500 adolescent using drugs were registered in the region. The introduction of drugs by injection w
- [The development of HIV infection in the Far-Eastern region of the Russian Federation]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):13-6. Unique Identifier : AIDSLINE MED/99195919
- Bogach VV; Trotsenko OE; Far-Eastern Center for Prophylaxis of AIDS, Khabarovsk, Russia.
- By May 18, 1998, 108 HIV-infected persons were registered in the Far-Eastern region. In recent years young people using narcotic drugs were involved in the epidemic process. The sources of the infection were mainly migrants arriving to the Far East from the Ukraine . HIV-infected p
- [HIV infection in children perinatally infected]
- Unique Identifier : AIDSLINE MED/99195920
- Voronin EE; Popova IA; Isaeva GN; Terekhin IuN; Sergeev PA
- During the period from 1987 to the middle of 1996 only 20
- [An analysis of an outbreak of HIV infection in the city of Svetlogorsk, the Republic of Byelarus, among persons using injected narcotics]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):18-9. Unique Identifier : AIDSLINE MED/99195921
- Kostikova LI; Firsova NP; Vasilevskaia AE; Skripko SM; Serovkaia TI; Center for Prophylaxis of AIDS, Minsk, Belarus.
- The examination of all persons suspected in the use narcotics (including suppliers and vendors of drugs) in Svetlogorsk ( Belarus ) for the presence of antibodies to HIV revealed 811 cases of HIV infection, i.e. 1% of the whole population was found to be infected by HIV. More than 9
- [The epidemiological characteristics of HIV infection in Turkmenistan]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):19-21. Unique Identifier : AIDSLINE MED/99195922
- Illiev SKh; Gaipova MB; Karmanova GA; Ministry of Public Health and Medical Industry, Center for; Prophylaxis and Control of AIDS, Ashgabad, Turkmenistan.
- In the presence of the low spread of HIV infection a sharp increase in sexually transmitted diseases is noted. Nevertheless, taking into account a rise in STD, the reality of the potential risk of the spread of HIV is emphasized. Thus, in 1996 morbidity is syphilis was found to grow 7.2 times in comparison with 1992,
- [The prevalence of the intravenous use of psychoactive preparations in Nizhegorod Province and the possible ways to prevent HIV infection among the users]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):21-3. Unique Identifier : AIDSLINE MED/99195923
- Moshkovich GF; Moiseev AP; Kuznetsov AV; Pikovskaia ED; Tarasov VK; Regional AIDS Center, Regional Narcological Dispensary, Nizhny; Novgorod, Russia.
- The number of users of intravenous drugs (UID), altogether from 35,000 to 25,000 persons, was determined by the method of coefficients. The analysis of 130 anonymous questionnaires, including 75 street questionnaires (61%) and 51 questionnaires (39%) distributed among UID in narcological and infectious hospitals showe
- [The characteristics of HIV infection during a sharp activation of the epidemic process in Rostov Province]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):23-4. Unique Identifier : AIDSLINE MED/99195924
- Saukhat SR; Tormozova NM; Rabinovich VD; Prokopenkova SA; Ryndich AA; North-Caucasian Regional Center for AIDS Control, Rostov-on-Don,; Russia.
- A considerable growth in cases of HIV infection in Rostov Province was registered in 1996-1997. Number of men was 525, number of women--196 cases, were registered. The highest index of HIV infection was noted in group of tested by epidemiological evidence (4494,4 per 100,000 tested persons), which was 57.2 times highe
- [The epidemic situation in relation to HIV infection in the Volga River region]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):24-6. Unique Identifier : AIDSLINE MED/99195925
- Nosov NN; Al'tova EE; Research Institute of Epidemiology and Microbiology, Nizhny; Novgorod, Russia.
- 1,036 HIV-infected persons were detected in the area by March 1, 1998; of these, 552 persons were detected in Nizhny Novgorod Province and 364 persons in Saratov Province. For all that at different periods 150 HIV-infected detainees were kept in the pretrial detention prisons of Nizhny Novgorod Province and 60 HIV-inf
- [The epidemic situation in relation to HIV infection in Ukraine (1987-1997)]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):26-9. Unique Identifier : AIDSLINE MED/99195926
- Shcherbinskaia AM; Kobyshcha IuV; Kruglov IuV; Chentsova NP; Bochkova LV; Maksimenok EV; Kislykh EN; Fedoruk NI; Luzan DP; Ukraine Center for Prophylaxis and Control of AIDS, Kiev,; Ukraine.
- The analysis of the dynamics of the epidemic process for 10 years made it possible to find out the presence of two separate epidemic waves of HIV infection. The first wave (1987-1994) was manifested as the slow type of the development of the epidemic, characterized mainly by sexual transmission. During this period 398
- [The clinico-epidemiological characteristics of HIV infection and AIDS in Ukraine]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):29-31. Unique Identifier : AIDSLINE MED/99195927
- Vovk AD; Shcherbinskaia AM; Chentsova NP; Kislykh EN; Maksimenok EV; Roshchenko LO; Antoniak SN; Shapiro AV; Gromashevsky Research Institute of Epidemiology and Infectious; Diseases, Ukraine Center for Prophylaxis and Control of AIDS,; Kiev.
- The summarized results of the observations of 449 hospitalized patients, aged mainly 18-37 years (40 patients with active AIDS, 43 patients with AIDS, other patients were HIV carriers and infected at the stage of lymphadenopathy). In most of the HIV-infected patients the infection process progressed in 3-5 years, whic
- Epidemiological surveillance for the spread of HIV infection. Foreword [editorial]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):3-4. Unique Identifier : AIDSLINE MED/99220829
- Piot P
- [HIV infection in the penitentiaries of Ukraine]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):31-3. Unique Identifier : AIDSLINE MED/99195928
- Gunchenko A; Kozhan N; Head Office of Public Health, Central Sanitary and; Epidemiological Station, Ministry of Internal Affairs, Kiev,; Ukraine.
- In connection with a sharp increase of the number of HIV-infected persons in the Ukraine the natural growth of the number of such persons in penitentiary institutions was registered, starting from 1995 (455 persons in 1995, 2,937 persons in 1996, 2,779 persons in 1997 and 173 pers
- [The determinants of the spread of HIV among injection drug addicts in Ukraine]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):34-6. Unique Identifier : AIDSLINE MED/99195929
- Kobyshcha Iu; Ministry of Public Health of Ukraine, Kiev.
- The main tendencies in the development of drug addiction in the Ukraine , the dynamics of the spread of HIV among drug addicts introducing drugs intravenously, epidemiological data on HIV, AIDS and drug addiction, as well as prognoses on the development of HIV infection are present
- [The detection of viral hepatitis markers in HIV-infected patients]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):36-7. Unique Identifier : AIDSLINE MED/99195930
- Kishtanova NA; Center for Prophylaxis and Control of AIDS, Elista, Republic of; Kalmykia, Russian Federation.
- The determination of markers of virus hepatitides B, C and D in 63 registered HIV-infected persons was made. The use of Russian and foreign EIA systems permitted the detection of markers of virus hepatitides 30.1% of HIV-infected persons, including 26.3% of children. Markers of hepatitis B virus were found to occur in
- [HIV infection in Russia in 1998]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):38. Unique Identifier : AIDSLINE MED/99195931
- Russian Research and Methodological Center for Prophylaxis and; Control of AIDS, Moscow.
- The statistic information about the distribution of HIV-infected persons in 1998 in different regions of Russian Federation was presented 3169 new cases of HIV-infected persons of Russia registered by 11.5 months in 1998. This are only 82.2% cases in comparison of cases (3856) which registered in 1997. The total numbe
- [The molecular epidemiological characteristics of the HIV-1 variants circulating among injection drug addicts on the territory of the CIS Nations]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):39-41. Unique Identifier : AIDSLINE MED/99195932
- Karamov EV; Shchelkanov MIu; Iudin AN; Gorbacheva AP; Burunova VV; Slavskii AA; Lukashov VV; Iaroslavtseva NG; Ivanovsky Research Institute of Virology, Moscow, Russia.
- Different strains of HIV-1, circulating among drug addicts introducing drugs intravenously and detected on the territories of Russia , Ukraine and Belarus , have been characterized by the methods of the compa
- [The structural and functional organization of the promoter region of the human CD4-receptor gene]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):41-3. Unique Identifier : AIDSLINE MED/99195933
- Zverev VV; Sidorov AV; Borzykh OA; Blinov VM; Research Institute of Viral Preparations, Moscow, Russia.
- Receptor CD4, expressed on the surface of immunocompetent cells, plays the key role in the pathogenesis of HIV infection, facilitating the penetration of the virus into the susceptible tissues of the host body. In this work the nucleotide sequence of the site on the gene of receptor CD4, responsible for the regulation
- [HIV-1 subtypes in Russia in 1987-1988]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):43-5. Unique Identifier : AIDSLINE MED/99195934
- Bobkov AF; Kazennova EV; Selimova LM; Ladnaia NN; Bobkova MR; Kravchenko AV; Pokrovskii VV; Ivanovsky Research Institute of Virology, Russian Research and; Methodological Center for Prophylaxis and Control of AIDS,; Moscow, Russia.
- The subtyping of 350 isolates of HIV-1, isolated on the territories of 38 subjects of the Russian Federation, was carried out. The analysis was made by the method of the comparative heteroduplex mobility assay, as well as by the determination of the sequence of genes env [correction of ens] (gp 120) and gag (p17-p24).
- [Recombinant human immunodeficiency viruses]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):45-7. Unique Identifier : AIDSLINE MED/99195935
- Bobkov AF; Kazennova EV; Selimova LM; Momot OF; Ladnaia NN; Bobkova MR; Pokrovskii VV; Ivanovsky Research Institute of Virology, Russian Research and; Methodological Center for Prophylaxis and Control of AIDS,; Moscow, Russia.
- Three types of recombinant human immunodeficiency virus have been found to circulate in Russia . The first type of the virus belongs to genotype gagAenvB, the second type belongs to genotype gagDenvG and the third type, to genotype gagAenvE. The virus of genotype gagAenvB circUlates
- [A recombinant HIV-1 strain causing an epidemic among injection drug addicts in Kaliningrad]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):47-9. Unique Identifier : AIDSLINE MED/99195936
- Korovina GI; Smol'skaia TT; Tashkinova IP; Momot OF; Kevlova NA; Liitsola K; Leinikki P; Salminen M; North-West Regional Center for Prophylaxis and Control of AIDS,; Pasteur Research Institute of Epidemiology and Microbiology, St.; Petersburg, Russia.
- The analysis of the genetic structure of HIV causing the epidemic in Kaliningrad Province. A new recombinant virus of subtype A/B was detected with the use of the polymerase chain reaction, the cloning of amplified fragments, sequencing and the phylogenetic analysis of the obtained data. The results thus obtained indi
- [The possible role of immunogenetic factors in the pathogenesis of HIV infection]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):49-52. Unique Identifier : AIDSLINE MED/99195937
- Volianskii IuL; Telepneva LG; Vasil'ev NV; Mechnikov Research Institute of Microbiology and Immunology,; Kharkov, Ukraine.
- In this review the data on the presence of associations between immunogenetic markers and the development of HIV infection are presented. Special attention is given to spatial relationships of genetic determinants, responsible for the synthesis of the components of the complement system on one hand and the genes contr
- [Emergency measures to control the spread of diseases caused by the human immunodeficiency virus]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):5-9. Unique Identifier : AIDSLINE MED/99195916
- Onishchenko GG; Beklemishcheva OA; Narkevich MI; Ministry of Public Health of the Russian Federation, State Duma,; Moscow, Russia.
- Since the middle of 1996 the growth of HIV-infected persons and AIDS morbidity are registered in Russia . In 1997 4,300 new cases of HIV infection were registered, which exceeded 1.6 times the total number of cases for the period of 1987-1996. The highest morbidity rate was observed
- [The HTHIV27 highly productive continuous cell line and its use for solving the fundamental and applied problems of HIV infection]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):52-7. Unique Identifier : AIDSLINE MED/99195938
- Miller GG; Kushch AA; Glukhova LA; Titova IV; Pokidysheva LN; Gamaleya Research Institute of Epidemiology and Microbiology,; Moscow, Russia.
- For the first time the detailed description of continuous cell line HTHIV27, remaining stable for more than 10 years, has been made. The stability of all biological characteristics and high productivity of the strain has made it possible to use it as a HIV producing strain for the construction of a diagnostic test sys
- [The use of a method for the quantitative determination of HIV-1 RNA for assessing the severity and prognosis of the development of the disease]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):57-9. Unique Identifier : AIDSLINE MED/99195939
- Smol'skaia TT; Sizova NV; Korovina GI; Maslov VP; Kevlova NA; Novikova VA; Bogoiavlenskii GV; Pasteur Research Institute of Epidemiology and Microbiology, City; Center for Prophylaxis and Control of AIDS, St. Petersburg,; Russia.
- The informatory role of a new marker of HIV infection, characterizing the content of HIV-1 RNA in the biological fluids of the patient s body, is evaluated. The quantitative determination of HIV-1 RNA, carried out in a single assay, was made in the blood of 25 HIV-infected patients. These studies confirmed that the de
- [The theory and practice of using in-house control in screening and verification studies for the diagnosis of HIV infection]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):60-1. Unique Identifier : AIDSLINE MED/99195940
- Shevelev BI; Ol'shanskii AIa; Redchenko EB; Preobrazhenskaia TV; Klimova NE; City Center for Prophylaxis and Control of AIDS, Moscow, Russia.
- Three batches of two diagnostic test kits for the in-house control (IHC) HIV infection were made up of the 8 pools of sera, containing antibodies to all antigens of HIV-1 (4) and HIV-negative sera (4) obtained from healthy donors. All sera used for this purpose did not contain antibodies to viruses of hepatitis A, B,
- [A retrospective study of the expediency of performing the immunoblot in conducting expert diagnosis at a center for the prevention and control of AIDS]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):62-3. Unique Identifier : AIDSLINE MED/99195941
- Matveeva EM; Kopnina EO; Research Institute of Epidemiology and Microbiology, Nizhny; Novgorod, Russia.
- In view of the fact that Russian immunoblot assay systems yield indefinite results, thus making it necessary to carry out prolonged dispensary observations of patients and their multiple examinations, the scheme of the expert diagnostics of HIV infection on the basis of EIA results is proposed. 51 sera which had yield
- [The organization of the work to determine antibodies to the human immunodeficiency virus in the Republic of Byelarus]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):63-4. Unique Identifier : AIDSLINE MED/99195942
- Meleshko LA; Center for Prophylaxis of AIDS, Minsk, Belarus.
- The study revealed that the method of mass screening for the detection of antibodies to HIV antigen, carried out in the Republic till 1993, proved to be economically and diagnostically unjustified. Starting from 1993, the work on the step-by-step reduction of groups to be tested for the presence of antibodies to HIV b
- [The testing policy for HIV infection in Ukraine]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):65-7. Unique Identifier : AIDSLINE MED/99195943
- Kobyshcha Iu; Ministry of Public Health of Ukraine, Kiev.
- The policy of the Ministry of Health of the Ukraine since 1987 concerning the control of the spread of HIV infection was analyzed. The main measure for the prophylaxis and epidemiological control of the infection was mass testing for HIV, carried out in accordance with the law ado
- [The characteristics of the course of tuberculosis in HIV-infected patients and prophylactic measures]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):67-9. Unique Identifier : AIDSLINE MED/99195944
- Frolova OP; Rakhmanova AG; Priimak AA; Vasil'ev AV; Voronin EE; Golikov VA; Potemina LP; Kochetkov NM; Tishkevich OA; Ministry of Public Health of the Russian Federation, Institute of; Tuberculosis, Moscow, Russia.
- Morbidity in HIV infection and tuberculosis in persons having these two infections in association was analyzed. According to the data for the end of the first quarter of 1997 the presence of association of HIV infection with tuberculosis was found in 91 patients. In 70.3% of cases HIV infection was contacted before th
- [The characteristics of the course of Leishmania and Pneumocystis opportunistic infections in immunosuppressed laboratory animals]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):69-71. Unique Identifier : AIDSLINE MED/99195945
- Lysenko AIa; Medical Academy of Post-Graduate Education, Moscow, Russia.
- Specific features of the course of Leishmania and Pneumocystis infections were studied on experimental models. Laboratory animals were subjected to medicinal suppression with Tricort-40. Leishmania infection in naturally susceptible animals was considerably aggravated (in comparison with the controls) in the presence
- [Burkitt's lymphosarcoma in a child with HIV infection]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):71-3. Unique Identifier : AIDSLINE MED/99195946
- Kuznetsova VV; Moscow City Center for Prophylaxis and Control of AIDS, Russia.
- A case of Burkitt s lymphosarcoma in an HIV-infected girl aged 4 years is described. The child was infected with HIV and hepatitis B virus in the hospital focus of infection at the age of 1 year 4 months. An attempt to treat lymphosarcoma with large doses of prednisolone and cytostatics (vincristine and cyclophosphami
- [Secondary diseases in HIV-infected patients]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):74-5. Unique Identifier : AIDSLINE MED/99195947
- Rossa NA; Zeliutkin VP; Center for Prophylaxis of AIDS, Minsk, Belarus.
- During the period of 1980-1996 the dispensary observation of 50 HIV-infected patients was carried out. The clinical forms of the infection were distributed among these patients as follows: asymptomatic forms in 18 patients, persisting generalized lymphadenopathy in 8 patients, pre-AIDS in 14 patients, AIDS in 10 patie
- [The clinical course of HIV infection in children who were parenterally infected]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):75-8. Unique Identifier : AIDSLINE MED/99195948
- Popova IA; Burova NV; Fomin IuA; Rakhmanova AG; Voronin EE; Galkina MV; Russian Clinical HIV/AIDS Center, St.Petersburg, Russia.
- The data on the study of the clinical course of HIV infection in 127 children, 124 from these infected in nosocomial foci. The overwhelming majority of the children were infected at the period of their stay in hospitals of Elista, Volgograd, Rostov-on-Don, Shakhty (Rostov Province) and Stavropol . At the end of 9-9.5
- [Autoantibodies to the thrombocytes and erythrocytes in HIV-infected patients]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):78-80. Unique Identifier : AIDSLINE MED/99195949
- Kravchenko AV; Poliakova AM; Khasbekova SG; Donskov SI; Astrina OS; Maleev VV; Central Research Institute of Epidemiology, Hematological; Research Center, Moscow, Russia.
- In 48 patients with HIV infection were tested for the presence of autologous and allogenic antibodies to red blood cells with the use of Coombs direct and indirect tests. 18 HIV-infected patients had IgG antibodies to thrombocytes, circulating in the blood (detected by the method of EIA) and bound to thrombocytes (de
- [The structure of the secondary diseases in HIV-infected patients in Russia]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):80-2. Unique Identifier : AIDSLINE MED/99195950
- Ermak TN; Kravchenko AV; Iurin OG; Pokrovskii VV; Russian Research and Methodological Center for Prophylaxis and; Control of AIDS, Moscow, Russia.
- In 95 patients with HIV infection (76 males and 19 females), observed in 1993-1997, the structure of secondary diseases was studied. During this period 58 patients (61.1%) died. In the structure of secondary diseases represented by 14 nosoforms prevailed cytomegalovirus and candida
- [The successes and problems in the treatment of HIV infection: a biochemist's view]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):82-4. Unique Identifier : AIDSLINE MED/99195951
- Kraevskii AA; Engelhardt Institute of Molecular Biology, Moscow, Russia.
- The problems of the effectiveness of the treatment of HIV-infected patients with 11 medicinal preparations and their combinations are discussed. 5 preparations ( AZT , zalcitabine, videx, s
- [New approaches to the chemotherapy of HIV infection]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):84-6. Unique Identifier : AIDSLINE MED/99195952
- Karamova EV; Sakhuriia IB; Shelkanov MIu; Burunova VV; Iaroslavtseva NG; Pavlova TV; Kornilaeva GV; Ivanovsky Research Institute of Virology, Moscow, Russia.
- The preclinical analysis of the effectiveness of AZT and new compounds (sulphatized derivate of chitosan (Sch) and adamantileted Sch, contents 10 and 18% of adamantine) prepared on the basis of chitosan (Ch), carried out with the use of the experiment
- [The prevention of HIV infection and STDs among injection drug addicts in Ukraine]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):86-9. Unique Identifier : AIDSLINE MED/99195953
- Andrushchak LI; Ministry of Public Health of Ukraine, Kiev.
- In 1996-1998 joint pilot Projects of the National Committee and the UNAIDS Program were carried out in 10 Ukrainian cities. The behavior determinants contributing to the spread of HIV infection, common for all regions under study, were determined. They were linked with the injectio
- [The forms and analysis of the results of work in preventing HIV infection among youth]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):89-91. Unique Identifier : AIDSLINE MED/99195954
- Shorokhov SSW; Poletaeva TA; Makarova LN; Regional Center for Prophylaxis and Control of AIDS, Kostroma,; Russia.
- Specialists of the AIDS Centre distributed questionnaires, specially developed by them, among a group of students of the Pedagogical University. The questionnaire contained 35 questions; of these, 21 questions were intended to find out what information on HIV infection and AIDS the students had and 14 questions dealt
- [A questionnaire survey of intravenous drug addicts (Moscow, May 1997-January 1998)]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):91-3. Unique Identifier : AIDSLINE MED/99195955
- Riley B; Mel'nikov V; Anreebva T; Baial' M; Medecins sans Frontieres, Moscow, Russia.
- Questionnaires were distributed among users of intravenous drugs (UID) on the basis of Narcological Hospital No. 17 in Moscow and in the streets of the city (altogether, respondents filled in 298 questionnaires in the hospital and 126 questionnaires in the streets). The average age of the respondents was 21-22 years.
- [The results of conducting a rapid assessment of the situation in relation to intravenous narcotic abuse in the city of Rostov-on-Don]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):93-6. Unique Identifier : AIDSLINE MED/99195956
- Kravchenko VF; Dunaev AG; Golubenko IA; Regional Narcological Dispensary, Rostov-on-Don, Russia.
- The main aspects of the spread and intravenous use of drugs in the city, contributing to the transmission of HIV infection among users of intravenous drugs (UID) have been studied. Anonymous questionnaires were distributed among 61 UID; of these, 50 were males (82%) and 11 were females (18%), mainly at the age of 19-3
- [The acceptance of a strategy for decreasing the risk of contracting an HIV infection among drug abusers]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):96-7. Unique Identifier : AIDSLINE MED/99195957
- Nosov NN; Tarasov VK; Research Institute of Epidemiology and Microbiology, Regional; Narcological Dispensary, Nizhny Novgorod, Russia.
- The narcotization level of the country is sufficiently high. According to some expert evaluations, the number of drug users varies between 2-4 million persons. Of these, about 100,000 are registered in narcotics service of the Ministry of Health of the Russian Federation and about 250,000 are registered in the system
- [The behavioral risk factors for contracting HIV infection in the intravenous administration of narcotics in abusers of psychoactive substances in the city of Rostov-on-Don]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):97-8. Unique Identifier : AIDSLINE MED/99195958
- Saukhat SR; Tormozova NM; Rabinovich VD; Orlov NV; Pankova AA; Vorontsov DV; Ryndich IV; North-Caucasian Regional Center for AIDS Control, Rostov-on-Don,; Russia.
- 150 persons (drug users) who had applied to the department of psycho-social consultations and voluntary tests for the presence of HIV infection and STD of the Regional AIDS Control Center, as well as partners of HIV-infected addicts in the intravenous use of drugs, were examined. Out of 150 examined persons 63 were fo
- [The prevention of HIV infection in abusers of psychoactive substances as a social behavioral problem]
- Zh Mikrobiol Epidemiol Immunobiol. 1999 Jan-Feb;(1):98-100. Unique Identifier : AIDSLINE MED/99195959
- Dolzhanskaia NA; Research Institute of Narcology, Moscow, Russia.
- This research has made it possible to outline and illuminate a range of problems which should be solved in planning concrete measures for the prophylaxis of HIV infection among the users of psychoactive substances. Such measures should also include those aimed at preventing children and adolescents from getting accust
- Fine needle aspiration diagnosis of mycobacterial lymphadenitis. Sensitivity and predictive value in the United States.
- Acta Cytol. 1999 Mar-Apr;43(2):153-7. Unique Identifier : AIDSLINE MED/99197775
- Ellison E; Lapuerta P; Martin SE; Department of Pathology, University of Southern California, Los; Angeles 90033, USA.
- OBJECTIVE: Fine needle aspiration (FNA) has proven valuable in diagnosing tuberculous lymphadenitis in countries with endemic mycobacterial infection (MI). Its role in developed countries, where sensitivity and positive predictive value are likely to be lower, has not been adequately explored. STUDY DESIGN: This retro
- HIV-1 (p24)-positive multinucleated giant cells in HIV-associated lymphoepithelial lesion of the parotid gland. A report of two cases.
- Acta Cytol. 1999 Mar-Apr;43(2):247-51. Unique Identifier : AIDSLINE MED/99197792
- Vicandi B; Jimenez-Heffernan JA; Lopez-Ferrer P; Patron M; Gamallo C; Colmenero C; Viguer JM; Department of Pathology, La Paz University Hospital, Madrid,; Spain.
- BACKGROUND: Cystic benign lymphoepithelial lesion (CBLL) is a well-recognized parotid disorder the diagnosis of which can be made on the basis of clinical findings, human immunodeficiency virus (HIV) testing, image studies and fine needle aspiration (FNA). Most aspirations are cystic, and the lesion can be recognized
- Association of body cavity-based lymphoma and human herpesvirus 8 in an HIV-seronegative male. Report of a case with immunocytochemical and molecular studies.
- Acta Cytol. 1999 Mar-Apr;43(2):299-302. Unique Identifier : AIDSLINE MED/99197803
- San Miguel P; Manzanal A; Garcia Gonzalez R; Bellas C; Department of Pathology, Hospital Universitario Ramon y Cajal,; Madrid, Spain.
- BACKGROUND: Recently lymphomas arising primarily in serosal surfaces have been found in patients with advanced acquired immunodeficiency syndrome (AIDS), but they very rarely seem to occur in human immunodeficiency virus (HIV)-negative patients. Studies on a subset of these lymphomas suggested that they represent a di
- Pure red cell aplasia associated to clonal CD8+ T-cell large granular lymphocytosis: dependence on cyclosporin A therapy.
- Acta Haematol. 1998;100(4):207-10. Unique Identifier : AIDSLINE MED/99141074
- Coutinho J; Lima M; dos Anjos Teixeira M; Cabeda JM; Leite F; Justica B; Service of Clinical Haematology, St. Antonio's Hospital, Porto,; Portugal.
- This case report details a single patient with pure red cell aplasia (PRCA) associated with clonal CD3+, TCRalphabeta+, TCR-Vbeta8+, CD8+, CD57+ large granular lymphocytosis whose anaemia did not respond to conventional immunosuppressive therapy but did respond to cyclosporin A (CsA). The patient has become dependent
- CDC calls for tuberculosis screening and treatment for all patients with HIV infection.
- Am Fam Physician. 1999 Mar 15;59(6):1682, 1687. Unique Identifier : AIDSLINE MED/99207945
- Rose VL
- Relative influences of sex, race, environment, and HIV infection on body composition in adults.
- Am J Clin Nutr. 1999 Mar;69(3):432-9. Unique Identifier : AIDSLINE MED/99173649
- Kotler DP; Thea DM; Heo M; Allison DB; Engelson ES; Wang J; Pierson RN Jr; St Louis M; Keusch GT; Department of Medicine, St. Luke's-Roosevelt Hospital Center,; Columbia University College of Physicians and Surgeons, New York,; NY 10025, USA. dpkotler@aol.com
- BACKGROUND: The factors that control body composition in disease are uncertain. OBJECTIVE: We planned to compare the relative influences of HIV infection, sex, race, and environment on body composition. METHODS: We analyzed results of body composition studies performed by bioelectrical impedance analysis in 1415 adult
- Genetic mapping to 10q23.3-q24.2, in a large Italian pedigree, of a new syndrome showing bilateral cataracts, gastroesophageal reflux, and spastic paraparesis with amyotrophy.
- Am J Hum Genet. 1999 Feb;64(2):586-93. Unique Identifier : AIDSLINE MED/99138672
- Seri M; Cusano R; Forabosco P; Cinti R; Caroli F; Picco P; Bini R; Morra VB; De Michele G; Lerone M; Silengo M; Pela I; Borrone C; Romeo G; Devoto M; Laboratorio di Genetica Molecolare, Istituto G. Gaslini, Largo G.; Gaslini n. 5, 16148 Genova Quarto, Italy. genseq@tin.it
- We have recently observed a large pedigree with a new rare autosomal dominant spastic paraparesis. In three subsequent generations, 13 affected individuals presented with bilateral cataracts, gastroesophageal reflux with persistent vomiting, and spastic paraparesis with amyotrophy. Bilateral cataracts occurred in all
- Postexposure prophylaxis for human immunodeficiency virus (HIV) infection following sexual assault.
- Am J Med. 1999 Mar;106(3):323-6. Unique Identifier : AIDSLINE MED/99204657
- Bamberger JD; Waldo CR; Gerberding JL; Katz MH; Department of Family and Community Medicine, University of; California, San Francisco, San Francisco Department of Public; Health, 94102, USA.
- Although the 1998 Centers for Disease Control and Prevention s guidelines for treatment of sexually transmitted diseases recommend offering postexposure prophylaxis for human immunodeficiency virus (HIV) infection following sexual assault, there are no detailed protocols on how to provide this treatment. Postexposure
- Systemic inflammatory reaction after starting highly active antiretroviral therapy in AIDS patients treated for extrapulmonary tuberculosis.
- Am J Med. 1999 Mar;106(3):371-2. Unique Identifier : AIDSLINE MED/99204662
- Furrer H; Malinverni R; AIDS Unit, Medical Policlinic, University Hospital Bern,; Switzerland.
- Human immunodeficiency virus screening among pregnant women in France: results from the 1995 National Perinatal Survey.
- Am J Obstet Gynecol. 1999 Mar;180(3 Pt 1):564-70. Unique Identifier : AIDSLINE MED/99176961
- Vayssiere C; Du Mazaubrun C; Breart G; Epidemiological Research Unit on Women and Children's Health,; Institut National de la Sante et de la Recherche Medicale; (INSERM), Unit 149, Paris, France.
- OBJECTIVE: The aim of the study was to assess how the French legislation requiring physicians to offer human immunodeficiency virus screening routinely at the beginning of prenatal care has been implemented and to explore areas in which improvement is required. Study Design: The survey included all births in
- Nasopharyngeal mucosa-associated lymphoid tissue lymphoma in patients infected with the human immunodeficiency virus.
- Am J Otolaryngol. 1999 Jan-Feb;20(1):56-8. Unique Identifier : AIDSLINE MED/99133614
- Sundaram K; Singh B; Har-El G; Department of Otolaryngology, the Long Island College Hospital,; State University of New York Health Science Center, Brooklyn,; USA.
- Novel CD4 and CD8 T-cell subsets.
- Allergy. 1998 Dec;53(12):1122-32. Unique Identifier : AIDSLINE MED/99127777
- Thomas MJ; Kemeny DM; Department of Immunology, King's College School of Medicine and; Dentistry, Rayne Institute, London, UK.
- Interactions of HIV-1 TAR RNA with Tat-derived peptides discriminated by on-line acoustic wave detector.
- Anal Chem. 1999 Mar 15;71(6):1167-75. Unique Identifier : AIDSLINE MED/99193457
- Furtado LM; Su H; Thompson M; Mack DP; Hayward GL; Department of Chemistry, University of Toronto, Ontario, Canada.
- The human immunodeficiency virus type I is strongly regulated at the transcriptional level through the interaction of an 86-amino acid protein (Tat) with a viral messenger RNA transcript. Accordingly, the binding of this protein and other cellular factors to the RNA has constituted a significant target for the develop
- Breast cancer and HIV: what do we know?
- Am Surg. 1999 Mar;65(3):209-11. Unique Identifier : AIDSLINE MED/99173614
- Guth AA; Division of General Surgery, New York University Medical Center,; New York City 10016, USA. guthaO@popmail.med.nyu.edu
- The present acquired human immunodeficiency syndrome-defining neoplasms are Kaposi s sarcoma, non-Hodgkins lymphoma, and cervical cancer. However, other malignancies have recently been associated with human immunodeficiency virus (HIV) infection. Is there also a link between breast cancer and HIV infection? Breast can
- Severe anal ulceration secondary to Histoplasma capsulatum in a patient with HIV disease.
- Am Surg. 1999 Apr;65(4):321-2. Unique Identifier : AIDSLINE MED/99204629
- Winburn GB; Yeh KA; Department of Surgery, Medical College of Georgia Hospital and; Clinics, Augusta 30912-4000, USA.
- Severe fungal infections have become increasingly common in the immunocompromised patient, including those infected with human immunodeficiency virus. Histoplasma capsulatum occurs in about five per cent of acquired immunodeficiency syndrome patients in the endemic areas of the Mississippi and Ohio River Valley. Immun
- High-dose trimethoprim-sulfamethoxazole therapy with corticosteroids in previously intolerant patients with AIDS-associated Pneumocystis carinii pneumonia [letter]
- Arch Dermatol. 1999 Mar;135(3):350-1. Unique Identifier : AIDSLINE MED/99184269
- Iborra C; Jouan M; Baril L; Katlama C; Bricaire F; Caumes E
- A phase II study of liposomal doxorubicin in the treatment of HIV-related Kaposi's sarcoma.
- Aust N Z J Med. 1998 Dec;28(6):777-83. Unique Identifier : AIDSLINE MED/99138353
- Newell M; Milliken S; Goldstein D; Lewis C; Boyle M; Dolan G; Ryan S; Cooper DA; National Centre in HIV Epidemiology and Clinical Research,; Faculty of Medicine, University of New South Wales, Sydney.
- OBJECTIVES: To evaluate the toxicity and clinical efficacy of liposomal encapsulated doxorubicin (DOX-SL) in the treatment of HIV-related Kaposi s sarcoma (KS). METHODS: DOX-SL 20-40mg/m2 was administered by intravenous infusion over 30-60 minutes every two weeks. Toxicity was assessed in all patients and response ass
- S. aureus superantigen protein A expands CD4(+)/CD8(+)/CD19(+)/CD34(+) cells in mice: a potential immunorestorer.
- Biochem Biophys Res Commun. 1999 Mar 5;256(1):142-6. Unique Identifier : AIDSLINE MED/99167353
- Ghosh AK; Sinha P; Das T; Sa G; Ray PK; Immunotechnology Section, Bose Institute, Calcutta, 700 054,; India.
- Protein A (PA) of Staphylococcus aureus is known for its immunostimulatory, anti-cancer, and anti-toxic properties. The present study revealed that PA stimulates specific immunocytes to act as a potential immunorestorer. It has also been shown that the percentage of various cell types bearing different clusters of dif
- Recruitment of TBP or TFIIB to a promoter proximal position leads to stimulation of RNA polymerase II transcription without activator proteins both in vivo and in vitro.
- Biochem Biophys Res Commun. 1999 Mar 5;256(1):45-51. Unique Identifier : AIDSLINE MED/99167335
- Huh JR; Park JM; Kim M; Carlson BA; Hatfield DL; Lee BJ; Institute for Molecular Biology and Genetics, Seoul National; University, Seoul, 151-742, Korea.
- Eukaryotic transcriptional activators may function, at least in part, to facilitate the assembly of the RNA polymerase II (pol II) preinitiation complex at the core promoter region through their interaction with a subset of components of the basal transcription machinery. Previous studies have shown that artificial te
- Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins.
- Biochem Biophys Res Commun. 1999 Mar 16;256(2):299-306. Unique Identifier : AIDSLINE MED/99180498
- Trinh DP; Brown KM; Jeang KT; Department of Biological Sciences, George Washington University,; 332 Lisner Hall, 2023 G Street N.W., Washington, DC 20052, USA.
- Epithelin/granulin growth factor is synthesized as a 593 amino acid precursor protein that contains 7.5 imperfectly conserved repeats of approximately 57 amino acids. Processed epithelin/granulin peptides have been isolated from vertebrate/invertebrate species and are growth factors implicated in epithelial and haemic
- Human immunodeficiency virus-1 infection requires pertussis toxin sensitive G-protein-coupled signalling and mediates cAMP downregulation.
- Biochem Biophys Res Commun. 1999 Mar 16;256(2):429-35. Unique Identifier : AIDSLINE MED/99180520
- Guntermann C; Murphy BJ; Zheng R; Qureshi A; Eagles PA; Nye KE; Department of Immunology, St Bartholomew's and the Royal London; School of Medicine and Dentistry, London, EC1A 7BE, United; Kingdom. christine_guntermann@macmailgw.dfci.harvard.edu
- The human immunodeficiency virus-1 (HIV-1) utilises CD4 and certain beta-chemokine receptors, mainly CCR-5 and CXCR4, for attachment and virus entry into T-lymphocytes and monocytes/macrophages. CD4 and beta-chemokine receptors participate in intracellular signalling via protein tyrosine kinases and G-protein-coupled
- Budget increases for AIDS [news]
- Aids Patient Care STDS. 1999 Jan;13(1):1. Unique Identifier : AIDSLINE AIDS/99153071
- Firms test employees [news]
- Aids Patient Care STDS. 1999 Jan;13(1):1. Unique Identifier : AIDSLINE AIDS/99153068
- Harvard Conference [news]
- Aids Patient Care STDS. 1999 Jan;13(1):1. Unique Identifier : AIDSLINE AIDS/99153069
- School clinics increase [news]
- Aids Patient Care STDS. 1999 Jan;13(1):1. Unique Identifier : AIDSLINE AIDS/99153070
- Indinavir-associated facial lipodystrophy in HIV-infected patients.
- Aids Patient Care STDS. 1999 Jan;13(1):11-6. Unique Identifier : AIDSLINE AIDS/99153075
- Ho TT; Chan KC; Wong KH; Lee SS; AIDS Unit, Department of Health, Hong Kong.; TTYHo@health.gcn.gov.hk
- The objectives of this study were to document the prevalence of facial lipodystrophy in patients with HIV infection receiving protease inhibitors and to identify associated factors. All patients with HIV infection receiving protease inhibitors seen at an HIV clinic
- Temporal trends in AIDS-related survival.
- Aids Patient Care STDS. 1999 Jan;13(1):17-22. Unique Identifier : AIDSLINE AIDS/99153076
- Baillargeon J; Borucki MJ; Williamson J; Department of Internal Medicine, University of Texas Medical; Branch, Galveston, USA. baillargeon@uthsasa.edu
- Although research indicates that AIDS-related survival has improved over calendar time, studies of temporal AIDS-related survival patterns are often confounded by the stage of AIDS diagnosis. The objective of the present study was therefore to assess temporal trends in AIDS-related survival from clinical indicators ot
- Hepatitis C lookback [news]
- Aids Patient Care STDS. 1999 Jan;13(1):2. Unique Identifier : AIDSLINE AIDS/99153072
- Inter-rater reliability of a modified Karnofsky Scale of Performance Status for HIV-infected individuals.
- Aids Patient Care STDS. 1999 Jan;13(1):23-8. Unique Identifier : AIDSLINE AIDS/99153077
- Fantoni M; Izzi I; Del Borgo C; Del Forno A; Damiano F; Pezzotti P; Franzetti M; Negri C; Quirini T; Zambelli A; Clinica Malattie Infettive, Universita Cattolica del Sacro; Cuore, Rome, Italy.
- The Karnofsky Scale of Performance Status (KPS) is a measure of health status that is widely used for HIV-infected persons, although few studies have documented its reliability and validity for HIV. We developed a modified KPS in an attempt to make it more appropriate for use in HIV-infected persons and evaluated its
- "Making all the difference in the world": how physicians can help HIV-seropositive patients become more involved in their healthcare.
- Aids Patient Care STDS. 1999 Jan;13(1):29-39. Unique Identifier : AIDSLINE AIDS/99153078
- Gerbert B; Love C; Caspers N; Linkins K; Burack JH; Division of Behavioral Sciences, School of Dentistry, University; of California San Francisco, USA. gerbert@itsa.ucsf.edu
- Physicians who treat HIV-seropositive patients can and should help them become more involved in their healthcare. This qualitative study investigated HIV-seropositive persons perspectives regarding when and how physicians could have a pronounced effect on their involvement. Sixty-four HIV-seropositive patients, diver
- The usual state of emergency [editorial]
- Aids Patient Care STDS. 1999 Jan;13(1):3-5. Unique Identifier : AIDSLINE AIDS/99153073
- Laurence J
- Disclosure of the diagnosis of HIV/AIDS to children born of HIV-infected mothers.
- Aids Patient Care STDS. 1999 Jan;13(1):41-5. Unique Identifier : AIDSLINE AIDS/99153079
- Lee CL; Johann-Liang R; Program for Children with AIDS, New York Hospital-Cornell; University Medical Center, New York, USA.
- HIV disease in perinatally infected patients is now treated as a chronic illness of childhood. The effective use of highly active anti-retroviral therapy has contributed to the improvements in the prognosis of this illness. As this population matures, the issue of disclosure of diagnosis becomes more significant and p
- The burden of care: the impact of HIV-associated dementia on caregivers.
- Aids Patient Care STDS. 1999 Jan;13(1):47-56. Unique Identifier : AIDSLINE AIDS/99153080
- Meadows J; Le Marechal K; Catalan J; Division of Neuroscience and Psychological Medicine, Imperial; College of Medicine, South Kensington, England.
- It has been suggested that up to 15% of patients with AIDS may develop HIV-associated dementia . The syndrome may be either abrupt or insidious and is characterized by poor prognosis. Increasing cognitive impairment will necessitate the patient receiving a substantial amount of care
- HIV/AIDS case histories: diagnostic problems. Hodgkin's disease, mixed cellularity type.
- Aids Patient Care STDS. 1999 Jan;13(1):57-8. Unique Identifier : AIDSLINE AIDS/99153081
- Roboz GJ; Godwin JH; Cornell University Medical College, New York, New York, USA.
- Indinavir trials stopped [news]
- Aids Patient Care STDS. 1999 Jan;13(1):59. Unique Identifier : AIDSLINE AIDS/99153083
- PIs and premature births [news]
- Aids Patient Care STDS. 1999 Jan;13(1):59. Unique Identifier : AIDSLINE AIDS/99153082
- Self-reported adherence not reliable [news]
- Aids Patient Care STDS. 1999 Jan;13(1):59. Unique Identifier : AIDSLINE AIDS/99153084
- Trial begins for rain forest agent [news]
- Aids Patient Care STDS. 1999 Jan;13(1):59-60. Unique Identifier : AIDSLINE AIDS/99153085
- NDA submitted for amprenavir [news]
- Aids Patient Care STDS. 1999 Jan;13(1):60-1. Unique Identifier : AIDSLINE AIDS/99153086
- Cannabis study planned [news]
- Aids Patient Care STDS. 1999 Jan;13(1):63. Unique Identifier : AIDSLINE AIDS/99153088
- STD data base available [news]
- Aids Patient Care STDS. 1999 Jan;13(1):63. Unique Identifier : AIDSLINE AIDS/99153087
- HIV and STD prevention update. CDC updates recommendations for hepatitis C.
- Aids Patient Care STDS. 1999 Jan;13(1):65-7. Unique Identifier : AIDSLINE AIDS/99153089
- Makulowich GS
- Coincidence of cytomegalovirus retinitis and central retinal vein occlusion in a patient with hemophilia B and AIDS.
- Aids Patient Care STDS. 1999 Jan;13(1):7-9. Unique Identifier : AIDSLINE AIDS/99153074
- Schiemann U; Steins M; Knospe V; Riedasch M; Domschke W; Stoll R; Department of Medicine, University of Muenster, Germany.
- A 37-year-old man with hemophilia B, acquired immunodeficiency syndrome, and a unilateral cytomegalovirus retinitis developed a central retinal vein occlusion. This vascular complication occurred despite effective antiviral drug treatment with improvement of the fundus and despite
- Presence of HLA-C-restricted cytotoxic T-lymphocyte responses in long-term nonprogressors infected with human immunodeficiency virus.
- Viral Immunol. 1998;11(3):119-29. Unique Identifier : AIDSLINE MED/99114962
- Nehete PN; Lewis DE; Tang DN; Pollack MS; Sastry KJ; Department of Veterinary Sciences, The University of Texas M.D.; Anderson Cancer Center, Bastrop 78602, USA.
- Approximately 5% of people with human immunodeficiency virus type 1 (HIV-1) infection remain free of disease for 10 or more years. These long-term nonprogressors (LTNPs) exhibit lower viral loads and stable CD4+ lymphocyte counts. The immunologic basis for this disease-free condition is not known. Because cytotoxic T
- A synthetic peptide from the first conserved region in the envelope protein gp160 is a strong T-cell epitope in HIV-infected chimpanzees and humans.
- Viral Immunol. 1998;11(3):147-58. Unique Identifier : AIDSLINE MED/99114965
- Nehete PN; Schapiro SJ; Johnson PC; Murthy KK; Satterfield WC; Sastry KJ; Department of Veterinary Sciences, The University of Texas M.D.; Anderson Cancer Center, Bastrop 78602, USA.
- We reported earlier that synthetic peptides corresponding to highly conserved regions in the envelope protein gp160 of the human immunodeficiency virus type 1 (HIV-1), in particular an 11-amino acid sequence (peptide 104) from the first conserved region at the amino-terminus, were capable of inducing strong HIV-specif
- Infection of rabbits with R29 strain of bovine immunodeficiency virus: virulence, immunosuppression, and progressive mesenteric lymphadenopathy.
- Viral Immunol. 1998;11(3):159-66. Unique Identifier : AIDSLINE MED/99114966
- Kalvatchev Z; Walder R; Perez F; Garzaro D; Barrios M; Laboratorio Virus Animales, Centro de Microbiologia y Biologia; Celular, Instituto Venezolano de Investigaciones Cientificas; (IVIC), Caracas, Venezuela.
- To assess the value of bovine immunodeficiency virus (BIV) infection as a model for human immunodeficiency virus (HIV) infection in man, we studied the impairment of certain immunologic functions in New Zealand white rabbits experimentally infected with an uncloned virulent iso
- CD3+/CD30+ circulating T lymphocytes are markedly increased in older subjects with Down's syndrome (Trisomy 21).
- Pathobiology. 1999 Mar-Apr;67(2):108-10. Unique Identifier : AIDSLINE MED/99147855
- Bertotto A; Crupi S; Fabietti GM; Troiani S; Parente C; Mezzetti D; Vaccaro R; Department of Pediatrics, Perugia University Medical School,; Policlinico Monteluce, Perugia, Italy.
- CD3+/CD30+ circulating T lymphocytes were found to be increased in the blood of individuals with Down s syndrome (DS; trisomy 21). This finding appears to be related to age as the numbers of CD3+/CD30+ T cells were dramatically enhanced in the circulation of older DS subjects. Since CD30 antigen expression is consider
- Cellular reservoirs for coronavirus infection of the brain in beta2-microglobulin knockout mice.
- Pathobiology. 1999 Mar-Apr;67(2):75-83. Unique Identifier : AIDSLINE MED/99147851
- Lavi E; Das Sarma J; Weiss SR; Division of Neuropathology, Department of Pathology and; Laboratory Medicine, University of Pennsylvania School of; Medicine, Philadelphia, PA 19104-6085,; USA.lavi@mail.med.upenn.edu
- Mouse hepatitis virus (MHV) A59 infection which causes acute encephalitis, hepatitis, and chronic demyelination, is one of the experimental models for multiple sclerosis. Previous studies showed that lethal infection of beta2-microglobulin knockout (beta2M(-/-)) mice required 500-fold less virus and viral clearance
- Cytomegalovirus retinitis in transition [letter]
- Aust N Z J Ophthalmol. 1999 Feb;27(1):89. Unique Identifier : AIDSLINE MED/99178431
- Tay-Kearney ML; French M; Mallal S
- Epitope-based assay to determine the efficiency of cleavage by HIV-1 protease.
- Biotechniques. 1999 Feb;26(2):242-4, 246. Unique Identifier : AIDSLINE MED/99147614
- Serio D; Weber IT; Harrison RW; Louis JM; Srinivasan A; Kimmel Cancer Institute, Philadelphia, PA, USA.
- Therapeutic vaccination with p24-VLP and zidovudine augments HIV-specific cytotoxic T lymphocyte activity in asymptomatic HIV-infected individuals.
- AIDS Res Hum Retroviruses. 1999 Jan 20;15(2):105-13. Unique Identifier : AIDSLINE MED/99151701
- Benson EM; Clarkson J; Law M; Marshall P; Kelleher AD; Smith DE; Patou G; Stewart GJ; Cooper DA; French RA; Department of Clinical Immunology, ICPMR, Westmead Hospital,; Wentworthville, NSW, Australia. elizab@westmead.wh.usyd.edu.au
- This study evaluates the impact of therapeutic vaccination with p24-VLP and zidovudine on the induction or maintenance of HIV-specific cytotoxic lymphocyte activity in a cohort of asymptomatic patients with CD4 counts greater than 400 cells/microl. In a dummy, randomized, phase II clinical trial of the therapeutic vac
- HIV-1MN recombinant glycoprotein 160 vaccine-induced cellular and humoral immunity boosted by HIV-1MN recombinant glycoprotein 120 vaccine. National Institute of Allergy and Infectious Diseases AIDS Vaccine Evaluation Group.
- AIDS Res Hum Retroviruses. 1999 Jan 20;15(2):115-32. Unique Identifier : AIDSLINE MED/99151702
- Gorse GJ; Corey L; Patel GB; Mandava M; Hsieh RH; Matthews TJ; Walker MC; McElrath MJ; Berman PW; Eibl MM; Belshe RB; St. Louis Department of Veterans Affairs, Medical Center, and; Saint Louis University, School of Medicine, Missouri 63106, USA.
- We evaluated prime-boost immunization with two recombinant envelope glycoprotein subunit vaccines (HIV-1MN recombinant gp160 vaccine in alum adjuvant [MN rgp160] and HIV-1MN recombinant gp120 vaccine in alum adjuvant [MN rgp120]) for safety and immunogenicity in healthy, HIV-1-uninfected adults. The rationale was to c
- Impact of HIV type 1 subtype variation on viral RNA quantitation.
- AIDS Res Hum Retroviruses. 1999 Jan 20;15(2):133-42. Unique Identifier : AIDSLINE MED/99151703
- Parekh B; Phillips S; Granade TC; Baggs J; Hu DJ; Respess R; Division of HIV, STD, TB Laboratory Research, Centers for Disease; Control and Prevention, Atlanta, Georgia 30333, USA. bsp1@cdc.gov
- We evaluated the performance of three HIV-1 RNA quantitation methods (Amplicor HIV-1 MONITOR-1.0, NASBA, and Quantiplex HIV RNA 2.0 [branched DNA (bDNA)]) using plasma specimens (N = 60) from individuals from Asia and Africa infected with one of three HIV-1 subtypes (A, Thai B [B ] or E; N = 20 each). Our results demo
- Distribution of the human immunodeficiency virus coreceptors CXCR4 and CCR5 in fetal lymphoid organs: implications for pathogenesis in utero.
- AIDS Res Hum Retroviruses. 1999 Jan 20;15(2):143-8. Unique Identifier : AIDSLINE MED/99151704
- Kitchen SG; Zack JA; Department of Medicine, UCLA School of Medicine and UCLA AIDS; Institute, Los Angeles, California 90095, USA.
- HIV entry into a cell requires the coordinate cell surface expression of CD4 and one of several chemokine coreceptors. Here we have examined the expression of the two most widely utilized HIV coreceptors, CXCR4 and CCR5, on various lymphoid tissues derived from the fetus. CXCR4 and CCR5 are differentially expressed on
- Increased association of glycoprotein 120-CD4 with HIV type 1 coreceptors in the presence of complex-enhanced anti-CD4 monoclonal antibodies.
- AIDS Res Hum Retroviruses. 1999 Jan 20;15(2):149-59. Unique Identifier : AIDSLINE MED/99151705
- Golding H; Ouyang J; Zaitseva M; Broder CC; Dimitrov DS; Lapham C; Division of viral products, CBER, Food and Drug Administration,; Bethesda, Maryland 20892, USA. goldingh@cber.fda.gov
- CD4-specific monoclonal antibodies (CG1, CG7, and CG8), which bind with a 5- to 10-fold higher avidity to preformed CD4-gp120 complexes than to CD4, were previously shown to recognize newly identified conformational epitopes in the D1-CDR3 region of CD4. In the current study, these and other complex-enhanced MAbs were
- Altered expression of CD4, CD54, CD62L, and CCR5 in primary lymphocytes productively infected with the human immunodeficiency virus.
- AIDS Res Hum Retroviruses. 1999 Jan 20;15(2):161-71. Unique Identifier : AIDSLINE MED/99151706
- Marodon G; Landau NR; Posnett DN; Graduate School of Medical Sciences, and the Department of; Medicine, Cornell University, Joan and Sanford I. Weill Medical; College, New York, New York 10021, USA.
- Infection of T cells with HIV-1 induces loss of CD4 and HLA class I from the cell surface. In the present article we have investigated whether changes in expression of other cell surface molecules could be related to HIV infection. To detect HIV-infected cells at the single-cell level, peripheral blood lymphocytes wer
- Increased expression of CD80 and CD86 in in vitro-infected CD3+ cells producing cytoplasmic HIV type 1 p24.
- AIDS Res Hum Retroviruses. 1999 Jan 20;15(2):173-81. Unique Identifier : AIDSLINE MED/99151707
- Jason J; Inge KL; Division of AIDS, Sexually Transmitted Diseases, and Tuberculosis; Laboratory Research (DASTLR); National Center for Infectious; Diseases; Centers for Disease Control and Prevention, Department; of Health and Human Services, Public H.
- Determining the effects of HIV infection on the expression of cell surface molecules has been limited by an inability to differentiate between productively infected cells and those without productive infection. We inoculated human peripheral blood mononuclear cells from healthy, human immunodeficiency virus type 1 (HI
- Virus threshold determines disease in SIVsmmPBj14-infected macaques.
- AIDS Res Hum Retroviruses. 1999 Jan 20;15(2):183-94. Unique Identifier : AIDSLINE MED/99151708
- O'Neil SP; Mossman SP; Maul DH; Hoover EA; Department of Pathology, Colorado State University, Fort Collins; 80523, USA.
- Simian immunodeficiency virus (SIV) variant SIVsmmPBj14 is unique in producing an acutely lethal enteropathic syndrome in pigtail macaques. To determine whether the nature of the PBj14 disease would be attenuated by decreasing virus input and to relate tissue virus burden to the severity of disease, we infected pigtai
- Effect of complement consumption by cobra venom factor on the the course of primary infection with simian immunodeficiency virus in rhesus monkeys.
- AIDS Res Hum Retroviruses. 1999 Jan 20;15(2):195-202. Unique Identifier : AIDSLINE MED/99151709
- Schmitz JE; Lifton MA; Reimann KA; Montefiori DC; Shen L; Racz P; Tenner-Racz K; Ollert MW; Forman MA; Gelman RS; Vogel CW; Letvin NL; Department of Medicine, Beth Israel Deaconess Medical Center,; Harvard Medical School, Boston, Massachusetts 02215, USA.; jschmitz@bidmc.harvard.edu
- Cobra venom factor (CVF)-induced consumption of complement proteins was used to investigate the role of complement in vivo in the immunopathogenesis of simian immunodeficiency virus of macaques (SIVmac) infection in rhesus monkeys. Repeated administration of CVF was shown to deplete complement to
- In vivo cell and tissue tropism of SIVsmmPBj14-bcl.3.
- AIDS Res Hum Retroviruses. 1999 Jan 20;15(2):203-15. Unique Identifier : AIDSLINE MED/99151710
- O'Neil SP; Mossman SP; Maul DH; Hoover EA; Department of Pathology, Colorado State University, Fort Collins; 80523, USA.
- To gain insight into the unique pathogenicity of simian immunodeficiency virus (SIV) variant PBj14, which produces an acutely lethal enteropathic syndrome in infected pigtail macaques, we investigated the cell and tissue tropisms of a highly pathogenic biologic clone (bcl.3) of SIVsmmPBj14. To compare the relative amo
- Dual transmission of subtype A and D HIV type 1 viruses from a Ugandan woman to her infant.
- AIDS Res Hum Retroviruses. 1999 Jan 20;15(2):217-21. Unique Identifier : AIDSLINE +
- Mellquist JL; Becker-Pergola G; Gu J; Guay L; Himes L; Kataaha P; Mmiro F; Ndugwa C; Jackson JB; Eshleman SH; Department of Pathology, Case Western Reserve University, School; of Medicine, Cleveland, Ohio 44106, USA.
- Dynamics of provirus load and lymphocyte subsets after interleukin 2 treatment in HIV-infected patients.
- Unique Identifier : AIDSLINE MED/99151700
- Zanussi S; Simonelli C; Bortolin MT; D'Andrea M; Comar M; Tirelli U; Giacca M; De Paoli P
- Analysis of effector cells in tumor-bearing mice pre-treated with active specific immunization followed by cyclophosphamide.
- Biotherapy. 1998;11(4):223-8. Unique Identifier : AIDSLINE MED/99133596
- Li L; Okino T; Kan N; Yamasaki S; Ichinose Y; Sugie T; Kanaoka S; Imamura M; Department of Surgery and Surgical Basic Science, Graduate School; of Medicine, Kyoto University, Japan.
- In order to analyse the effector population in an immunization model, we treated BALB/c mice with intraperitoneal (i.p.) active specific immunization (ASI), which consists of interleukin (IL)-1-beta and sonicated tumor supernatant (SS) of a plasmacytoma MOPC-104E followed by i.p. injection of cyclophosphamide (CY). Th
- Low dose oral interferon alpha 2a in HIV-1 seropositive patients: a double-blind, placebo-controlled trial.
- Biotherapy. 1998;11(4):229-34. Unique Identifier : AIDSLINE MED/99133597
- Wright SE; Hutcheson DP; Cummins JM; Veterans Affairs Medical Center and Department of Internal; Medicine, Texas Tech University Health Sciences Center, Amarillo,; USA.
- Low dose oral interferon alpha has been shown to be of benefit in viral disease in animals. In a double-blind, placebo-controlled trial, 177 patients seropositive for HIV-1 were randomly assigned to receive placebo or recombinant human interferon alpha 2a (rIFN alpha). Endpoints were survival, alteration of disease cl
- Classification, diagnostic criteria, and treatment recommendations for orofacial manifestations in HIV-infected pediatric patients. Collaborative Workgroup on Oral Manifestations of Pediatric HIV Infection.
- Unique Identifier : AIDSLINE MED/99220677
- Ramos-Gomez FJ; Flaitz C; Catapano P; Murray P; Milnes AR; Dorenbaum A
- The criteria for diagnosis of HIV-related oral lesions in adults are well established, but corresponding criteria in the pediatric population are not as well defined. The Collaborative Workgroup on the Oral Manifestations of Pediatric HIV infection reached a consensus, based upon available data, as to the presumptive
- Major and minor groove contacts in retroviral integrase-LTR interactions.
- Biochemistry. 1999 Mar 23;38(12):3624-32. Unique Identifier : AIDSLINE MED/99192399
- Wang T; Balakrishnan M; Jonsson CB; Department of Chemistry & Biochemistry and Program in Molecular; Biology, New Mexico State University, Las Cruces, New Mexico; 88003, USA.
- The 3 -processing activities of HIV-1, HTLV-2, and M-MuLV integrases (INs) with their corresponding U5 end of the viral DNA molecule were examined to define functional group determinants of U5 terminus recognition and catalysis. Nucleotide analogues were incorporated into the U5 terminus to produce conservative modifi
- NF-kappa B binding mechanism: a nuclear magnetic resonance and modeling study of a GGG --> CTC mutation.
- Biochemistry. 1999 Mar 30;38(13):3883-94. Unique Identifier : AIDSLINE PDB/4KBD
- Tisne C; Hartmann B; Delepierre M; Laboratoire de RMN, Institut Pasteur, CNRS URA 1129, Paris,; France.
- We present the solution structure of the nonpalindromic 16 bp DNA 5 d(CTGCTCACTTTCCAGG)3 . 5 d(CCTGGAAAGTGAGCAG)3 containing a mutated kappaB site for which the mutation of a highly conserved GGG tract of the native kappaB HIV-1 site to CTC abolishes NF-kappaB binding. 1H and 31P NMR spectroscopies have been used tog
- Natural history and prognostic factors for survival in patients with acquired immune deficiency syndrome (AIDS)-related primary central nervous system lymphoma (PCNSL).
- Crit Rev Oncog. 1998;9(3-4):199-208. Unique Identifier : AIDSLINE MED/99215811
- Raez LE; Patel P; Feun L; Restrepo A; Raub WA Jr; Cassileth PA; Department of Medicine, University of Miami School of Medicine,; Sylvester Comprehensive Cancer Center, FL, USA.
- The incidence of primary central nervous system lymphoma (PCNSL) is increasing rapidly. It will be the most common primary malignant neoplasm of the brain by the year 2000. PCNSL is an important lethal complication in acquired immunodeficiency syndrome (AIDS) patients. Our objective was to study the natural history an
- Primate retroviruses and oncogenesis.
- Crit Rev Oncog. 1998;9(3-4):209-53. Unique Identifier : AIDSLINE MED/99215812
- Sanguineti-Diaz C; Rodriguez-Tafur J; Patarca R; Departamento de Patologia Clinica, Hospital Nacional Guillermo; Almenara Irigoyen del Instituto Peruano de Seguridad Social,; GrupoLatinoamericano de Immunodeficiencias Primarias (LAGID).
- This review summarizes the current knowledge and role of human and nonhuman primate retroviruses in the pathogenesis of neoplasia.
- Clonal expansion of gammadelta-T lymphocytes in an HTLV-I carrier, associated with chronic neutropenia and rheumatoid arthritis.
- Ann Hematol. 1999 Feb;78(2):101-4. Unique Identifier : AIDSLINE MED/99186890
- Horiuchi T; Hirokawa M; Satoh K; Kitabayashi A; Muira AB; Department of Internal Medicine III, Akita University School of; Medicine, Japan.
- We report on an HTLV-I carrier showing clonal proliferation of gammadelta-T lymphocytes associated with chronic neutropenia and rheumatoid arthritis (RA). A 75-year-old Japanese woman had a 20-year history of RA and was found to have neutropenia and lymphocytosis by routine examinations. Her white cell count was 5,800
- Treatment of chancroid, 1997.
- Clin Infect Dis. 1999 Jan;28 Suppl 1:S14-20. Unique Identifier : AIDSLINE MED/99152432
- Schmid GP; Division of Sexually Transmitted Diseases Prevention, Centers for; Disease Control and Prevention, Atlanta, Georgia 30333, USA.; gpsl@cdc.gov
- Since the 1993 treatment guidelines for sexually transmitted diseases were published by the Centers for Disease Control and Prevention, experience has indicated that the regimens recommended then remain largely effective. The recommended therapies--with azithromycin (1 g orally, once), ceftriaxone (250 mg intramuscula
- New therapies and prevention strategies for genital herpes.
- Clin Infect Dis. 1999 Jan;28 Suppl 1:S4-13. Unique Identifier : AIDSLINE MED/99152431
- Wald A; Department of Medicine and Epidemiology, University of; Washington, Seattle 98122, USA. annawald@u.washington.edu
- Genital herpes is among the most prevalent sexually transmitted diseases. Optimal management of genital herpes includes accurate diagnosis, antiviral therapy, and counseling of patients about complications and transmission of herpes simplex virus (HSV). Antiviral therapy offers
- Diagnosis and treatment of sexually acquired proctitis and proctocolitis: an update.
- Unique Identifier : AIDSLINE MED/99152439
- Rompalo AM
- Sexually transmitted gastrointestinal syndromes include proctitis, proctocolitis, and enteritis. These syndromes can be caused by one or multiple pathogens. Routes of sexual
- [A tuberculous liver abscess in HIV (letter)]
- An Med Interna. 1999 Feb;16(2):105-6. Unique Identifier : AIDSLINE MED/99209089
- Fernandez Muinelo M; Martinez Fernandez R; Iglesias Gallego M; del Rio Romero D; Arrojo Martinez P
- [Tuberculosis in the year 2000 (editorial)]
- An Med Interna. 1999 Feb;16(2):57-8. Unique Identifier : AIDSLINE MED/99209074
- Martinez Cruz R; Alvarez-Sala JL
- [The risk-benefit of the treatment of tuberculosis with a high bacilloscopy sensitivity in a provincial hospital]
- An Med Interna. 1999 Feb;16(2):59-64. Unique Identifier : AIDSLINE MED/99209075
- Geijo Martinez MP; Martinez Medina C; Herranz C; Ruiz Ribo MD; Unidad de Enfermedades Infecciosas, Hospital Virgen de La Luz,; Cuenca.
- BACKGROUND: To know the incidence and type of hepatic toxicity (HTX) of the tuberculous chemotherapy and to value the risk-benefit of treatment in our elderly population in a high sensibility context of the bacilloscopy. PATIENTS AND METHODS: Prospective study of 161 tuberculous patients with standards of 6 months, fr
- [The characteristics of patients who have died from tuberculosis]
- An Med Interna. 1999 Feb;16(2):65-8. Unique Identifier : AIDSLINE MED/99209076
- Golpe Gomez R; Cifrian Martinez JM; Fernandez Rozas SM; Fernandez Infante B; Marin Martinez B; Alonso Martin MA; Seccion de Neumologia, Hospital Universitario Marques de; Valdecilla, Universidad de Cantabria, Santander.
- OBJECTIVE: To analyze the characteristics of the patients died from tuberculosis (TB) in our hospital. METHOD: We retrospectively reviewed the records of the 46 patients died in-hospital from TB between january, 1992 and june, 1997. MEAN AGE: 55 +/- 19 years (19-85). 35 (76%) males and 11 (24%) females. RESULTS: Diagn
- Hepatitis C viral infection is associated with fibrillary glomerulonephritis and immunotactoid glomerulopathy.
- J Am Soc Nephrol. 1998 Dec;9(12):2244-52. Unique Identifier : AIDSLINE MED/99063524
- Markowitz GS; Cheng JT; Colvin RB; Trebbin WM; D'Agati VD; Department of Pathology, Columbia University, College of; Physicians and Surgeons, New York, New York, USA.
- The most common form of glomerular disease seen in association with hepatitis C virus (HCV) infection is membranoproliferative glomerulonephritis, with or without associated cryoglobulinemia. This study examines four cases of fibrillary glomerulonephritis and two cases of immunotactoid glomerulopathy in association wi
- Mycophenolate mofetil prevents the induction of active Heymann nephritis: association with Th2 cytokine inhibition.
- J Am Soc Nephrol. 1998 Dec;9(12):2272-82. Unique Identifier : AIDSLINE MED/99063527
- Penny MJ; Boyd RA; Hall BM; Department of Medicine, Liverpool Hospital and the University of; New South Wales, Australia.
- The effect of mycophenolate mofetil (MMF) was examined in active Heymann nephritis (HN), an animal model of human membranous nephropathy. HN was induced in Lewis rats with Fx1A/complete Freund s adjuvant (CFA), and controls only received CFA. The induction of HN was prevented by MMF (30 mg/kg per d) from 0 to 4 wk aft
- HIV-associated nephropathy: outcome and prognosis factors. Groupe d' Etudes Nephrologiques d'Ile de France.
- J Am Soc Nephrol. 1998 Dec;9(12):2327-35. Unique Identifier : AIDSLINE MED/99063533
- Laradi A; Mallet A; Beaufils H; Allouache M; Martinez F; Department of Nephrology, GERC, Institut National de la Sante et; de la Recherche Medicale U436, Groupe Hospitalier; Pitie-Salpetriere, Paris, France.
- Records of 102 patients with biopsy-proven HIV-associated nephropathy (HIVAN) admitted to 18 hospitals in the Paris area from 1984 through 1996 were retrospectively reviewed. Demographics and clinical and laboratory features of the cohort were determined, and prognostic factors of renal and patient survival were analy
- Role of cytokines in transplantation tolerance: lessons learned from gene-knockout mice.
- J Am Soc Nephrol. 1998 Dec;9(12):2361-7. Unique Identifier : AIDSLINE MED/99063539
- Lakkis FG; The Carlos and Marguerite Mason Transplantation Research Center,; Department of Medicine, Veterans Affairs Medical Center and Emory; University, Atlanta, Georgia 30033, USA.
- Findings and benefit of liver biopsies in 46 patients infected with human immunodeficiency virus.
- J Gastroenterol Hepatol. 1999 Feb;14(2):146-9. Unique Identifier : AIDSLINE MED/99151753
- Piratvisuth T; Siripaitoon P; Sriplug H; Ovartlarnporn B; Department of Medicine, Prince of Songkla University, Hat Yai,; Thailand. ptimmy@ratree.psu.ac.th
- AIMS: The aim of this work is to evaluate the role of liver biopsy and to determine the histological findings in patients infected with the human immunodeficiency virus (HIV) who have abnormal liver function tests (LFT). METHODS: We performed a percutaneous liver biopsy in 46 HIV-seropositive patients with abnormal LF
- CD4/CD8 double-positive adult T cell leukemia with preceding cytomegaloviral gastroenterocolitis.
- Int J Hematol. 1999 Feb;69(2):92-5. Unique Identifier : AIDSLINE MED/99170851
- Ohata J; Matsuoka M; Yamashita T; Tojo A; Tani K; Asano S; Department of Hematology, University of Tokyo, Japan.
- We present a rare case of adult T cell leukemia (ATL) in which leukemic T cells simultaneously expressed CD4 and CD8 surface antigens and refractory cytomegalovirus ( CMV )-induced gastroenterocolitis preceded its clinical onse
- Reflecting our past--looking toward our future [editorial]
- J Assoc Nurses AIDS Care. 1999 Jan-Feb;10(1):15-6. Unique Identifier : AIDSLINE MED/99133428
- Sowell R
- Grappling with global concerns in the search for an HIV vaccine.
- J Assoc Nurses AIDS Care. 1999 Jan-Feb;10(1):17-20. Unique Identifier : AIDSLINE MED/99133429
- Grady C
- There is a need for increasing international collaboration in the search for a safe and effective HIV vaccine. In addition to the ethical issues that must be considered in conducting any clinical research, unique issues arise in vaccine research and in international research. Careful deliberation and guideline develop
- Stress and HIV disease progression: psychoneuroimmunological framework.
- J Assoc Nurses AIDS Care. 1999 Jan-Feb;10(1):21-31. Unique Identifier : AIDSLINE MED/99133430
- Robinson FP; Mathews HL; Witek-Janusek L; Catholic Health Partners, Chicago, IL, USA.
- Psychoneuroimmunology (PNI) is the study of the interrelationships among behavior, neural and endocrine function, and the immune system. PNI investigates the relationships among stress, physiological dysregulation, and health outcomes. Research has supported the theory that emotional distress and the resultant neuroen
- Patient appraisal of mandarin orange didanosine: implications for adherence and well-being.
- J Assoc Nurses AIDS Care. 1999 Jan-Feb;10(1):35-41. Unique Identifier : AIDSLINE MED/99133431
- Reynolds NR; Neidig JL; Brashers DE; College of Nursing, Ohio State University, USA.
- Didanosine ( Videx , ddI) has been shown to be an effective agent in the treatment of HIV disease. However, patients have had difficulties adhering to didanosine preparations due to taste aversion and/or associated nausea. The efficacy of didanosine may
- Spirituality, psychological well-being, and HIV symptoms for African Americans living with HIV disease.
- J Assoc Nurses AIDS Care. 1999 Jan-Feb;10(1):42-50. Unique Identifier : AIDSLINE MED/99133432
- Coleman CL; Holzemer WL; Department of Nursing, University of Southern California, Los; Angeles 90033, USA.
- The purpose of this descriptive cross-sectional study was to explore the contribution of spiritual well-being and human immunodeficiency virus (HIV) symptoms to psychological well-being measured by depression, hope, and state-trait anxiety in a sample of 117 African-American men and women with a mean age of 38 years l
- Women and the prevention of HIV infection: an integrative review of the literature.
- J Assoc Nurses AIDS Care. 1999 Jan-Feb;10(1):51-63. Unique Identifier : AIDSLINE MED/99133433
- Mallory C; Fife BL; Center for Developmental Science, University of North Carolina at; Chapel Hill, USA.
- In the United States , recent epidemiological evidence suggests that the epidemic of AIDS is growing rapidly among women. However, the theories used to guide research in the area of prevention of HIV infection often do not account for gender. As a result, research with women has been li
- Management of occupational exposures to HIV: updated guidelines for postexposure prophylaxis. Centers of Disease Control and Prevention.
- J Assoc Nurses AIDS Care. 1999 Jan-Feb;10(1):66-70. Unique Identifier : AIDSLINE MED/99133434
- Porche D; Franklin C; Nicholls State University, USA.
- Designing a short-term process evaluation of a wellness center serving persons with HIV/AIDS.
- J Assoc Nurses AIDS Care. 1999 Jan-Feb;10(1):71-5. Unique Identifier : AIDSLINE MED/99133435
- Sharts-Hopko NC; Kelley JM; Nazar KL; College of Nursing, Villanova University, USA.
- Human immunodeficiency virus type 2 [news]
- J Assoc Nurses AIDS Care. 1999 Jan-Feb;10(1):76-8. Unique Identifier : AIDSLINE MED/99133436
- New study shows average per patient cost of HIV care in managed care setting stabilized in 1997 [news]
- J Assoc Nurses AIDS Care. 1999 Jan-Feb;10(1):79. Unique Identifier : AIDSLINE MED/99133437
- Detailed deletion mapping of the long arm of chromosome 6 in adult T-cell leukemia.
- Blood. 1999 Jan 15;93(2):613-6. Unique Identifier : AIDSLINE MED/99102391
- Hatta Y; Yamada Y; Tomonaga M; Miyoshi I; Said JW; Koeffler HP; Division of Hematology/Oncology, Cedars-Sinai Research Institute,; UCLA School of Medicine, Los Angeles, CA, USA.
- Previously, we have found that the loss of heterozygosity (LOH) was frequently observed on chromosome 6q in acute/lymphoma-type adult T-cell leukemia (ATL), suggesting a putative tumor-suppressor gene for ATL may be present on chromosome 6q. To further define a region containing this gene, we performed fine-scale dele
- What is Burkitt's lymphoma and when is it endemic? [letter]
- Blood. 1999 Jan 15;93(2):758. Unique Identifier : AIDSLINE MED/99226428
- Wright DH
- Human immunodeficiency virus-associated Hodgkin's disease derives from post-germinal center B cells.
- Blood. 1999 Apr 1;93(7):2319-26. Unique Identifier : AIDSLINE MED/99192449
- Carbone A; Gloghini A; Larocca LM; Antinori A; Falini B; Tirelli U; Dalla-Favera R; Gaidano G; Division of Pathology and the AIDS Program, Centro di Riferimento; Oncologico, Istituto Nazionale Tumori, Istituto di Ricovero e; Cura a Carattere Scientifico (IRCCS), Aviano, Italy.; acarbone@ets.it
- Human immunodeficiency virus-associated Hodgkin s disease (HIV-HD) displays several peculiarities when compared with HD of the general population. These include overrepresentation of clinically aggressive histologic types and frequent infection of Reed-Sternberg (RS) cells by Epstein-Barr virus (EBV). Recently, we hav
- Constitutive activation of NF-kappaB in primary adult T-cell leukemia cells.
- Blood. 1999 Apr 1;93(7):2360-8. Unique Identifier : AIDSLINE MED/99192454
- Mori N; Fujii M; Ikeda S; Yamada Y; Tomonaga M; Ballard DW; Yamamoto N; Department of Preventive Medicine and AIDS Research, Research; Field of Pathogenesis and Clinical Sciences, Institute of; Tropical Medicine, Nagasaki University, Japan.
- Human T-cell leukemia virus type I (HTLV-I) is an etiologic agent of adult T-cell leukemia (ATL). The viral protein Tax induces the activation and nuclear translocalization of transcription factor NF-kappaB, which is proposed to play a crucial role in the transformation of T cells by HTLV-I. However, the HTLV-I genes
- Metabolic characterization of AIDS dementia complex by spectroscopic imaging.
- J Magn Reson Imaging. 1999 Jan;9(1):10-8. Unique Identifier : AIDSLINE MED/99153716
- Moller HE; Vermathen P; Lentschig MG; Schuierer G; Schwarz S; Wiedermann D; Evers S; Husstedt IW; Westfalische Wilhelms-Universitat Munster, Institut fur; Physikalische Chemie, Germany. moeller@uni-muenster.de
- Prospective proton chemical shift imaging (CSI) of the brain was performed in 30 HIV- 1-seropositive patients and 11 healthy controls. Significant (P
- Serum prealbumin in institutionalized populations.
- Nutrition. 1999 Jan;15(1):51-2. Unique Identifier : AIDSLINE MED/99116588
- Kaplan LA; Minkowitz G; Rakower D; Department of Pathology, New York University Medical Center, New; York, USA. lk27@is2.nyu.edu
- Home parenteral nutrition in acquired immunodeficiency syndrome patients [editorial]
- Nutrition. 1999 Jan;15(1):68-9. Unique Identifier : AIDSLINE MED/99116597
- Melchior JC; Messing B
- Glutathione redox disturbances in human immunodeficiency virus infection: immunologic and therapeutic consequences [editorial]
- Nutrition. 1999 Feb;15(2):165-7. Unique Identifier : AIDSLINE MED/99144398
- Aukrust P; Muller F
- [The role of bacterial diarrhea in developing countries]
- Bull Soc Pathol Exot. 1998;91(5 Pt 1-2):402-5. Unique Identifier : AIDSLINE MED/99178100
- Dosso M; Coulibaly M; Kadio A; Institut Pasteur de Cote d'Ivoire.
- Bacterial diarrheas in developing countries remain a major public health problem. Cholera is endemo-endemic since 1970. Clusters of Shigella infections are commonly observed during the rainy season. Other enteropathogen cause nosocomial infections and foodborne diseases. The HIV epidemic determined the emergence of a
- Routine prenatal HIV screening program launched.
- Can Fam Physician. 1999 Mar;45:700-2, 708-9. Unique Identifier : AIDSLINE MED/99199582
- Ketchum P
- Hope for HIV patients. News from the 12th International Conference on HIV and AIDS [news]
- Can Fam Physician. 1999 Mar;45:829-31. Unique Identifier : AIDSLINE MED/99199584
- Elliott EB
- Progressive outer retinal necrosis syndrome as an early manifestation of human immunodeficiency virus infection.
- J Formos Med Assoc. 1999 Feb;98(2):141-4. Unique Identifier : AIDSLINE MED/99183341
- Yang CM; Wang WW; Lin CP; Department of Ophthalmology, National Taiwan University Hospital,; Taipei, Taiwan.
- Progressive outer retinal necrosis syndrome is a recently recognized variant of necrotizing herpetic retinopathy, developing in patients with acquired immune deficiency syndrome (AIDS) or other conditions causing immune compromise. We report a case in which the diagnosis of retinal necrosis syndrome was made before th
- South African public sceptical about new AIDS "cure" [news]
- BMJ. 1999 Mar 20;318(7186):757. Unique Identifier : AIDSLINE MED/99184905
- Sidley P
- Drug points: severe ergotism associated with interaction between ritonavir and ergotamine.
- BMJ. 1999 Mar 20;318(7186):771. Unique Identifier : AIDSLINE MED/99184911
- Liaudet L; Buclin T; Jaccard C; Eckert P; Critical Care Division, Department of Internal Medicine (Service; B), University Hospital, 1011 Lausanne, Switzerland.
- Severe weight loss: the predominant clinical presentation of tuberculosis in patients with HIV infection in India.
- Natl Med J India. 1998 Nov-Dec;11(6):256-8. Unique Identifier : AIDSLINE MED/99183359
- Hira SK; Dupont HL; Lanjewar DN; Dholakia YN; Sir J.J. Group of Hospitals, Maharashtra, India.
- BACKGROUND: Tuberculosis is endemic in India and its prevalence is reported to be increasing in patients with human immuno-deficiency virus (HIV) infection. Several factors, including the level of immune deficiency, influence the clinical presentation of HIV-associated tuberculosis.
- The world of HIV and disease, and some new approaches to block it.
- Bull Mem Acad R Med Belg. 1998;153(7-9):339-42. Unique Identifier : AIDSLINE MED/99200170
- Gallo R; Institute for Human Virology, University of Maryland, Baltimore,; USA.
- Managing drug reactions to sulfonamides and other drugs in HIV infection: desensitization rather than rechallenge?
- Pharm World Sci. 1998 Dec;20(6):253-7. Unique Identifier : AIDSLINE MED/99138473
- Koopmans PP; Burger DM; Department of General Internal Medicine, University Hospital; Nijmegen St. Radboud, The Netherlands.
- Drug reactions in patients with HIV infection, e.g. fever or rash, are a frequently occurring clinical problem. These side effects particularly are observed with sulfonamides; however, many other drugs have also shown to induce allergic reactions when given to patients with HIV infection. The production of hydroxylami
- [Should infertility be treated in couples where one of the partners is HIV seropositive?]
- Contracept Fertil Sex. 1999 Feb;27(2):118-20. Unique Identifier : AIDSLINE MED/99207289
- Auroux M; CHU de Bicetre.
- [For or against infertility treatment in couples where one partner is HIV seropositive]
- Contracept Fertil Sex. 1999 Feb;27(2):120-1. Unique Identifier : AIDSLINE MED/99207290
- Plachot M; CHI Jean Rostand, Sevres.
- AIDS and HIV infection in the United Kingdom: monthly report.
- Commun Dis Rep CDR Wkly. 1999 Feb 26;9(9):85-6. Unique Identifier : AIDSLINE MED/99209141
- Are we winning the battle against the human immunodeficiency virus [editorial]
- Br J Hosp Med. 1998 Nov 19-Dec 9;58(10):486-8. Unique Identifier : AIDSLINE MED/99209529
- Sullivan AK; Nelson MR
- Victimization experiences and HIV infection in women: associations with serostatus, psychological symptoms, and health status.
- J Trauma Stress. 1999 Jan;12(1):41-58. Unique Identifier : AIDSLINE MED/99151203
- Kimerling R; Armistead L; Forehand R; Stanford University Medical Center, CA 94305, USA.
- The present investigation evaluates the relationship between HIV infection and victimization with regard to the interplay of these two factors as they relate to mental and physical health. Eighty eight inner-city low income African-American women who are HIV-infected and a demographically similar comparison group of w
- Bacteria-specific T cells response. What role for HLA molecules?
- Rev Rhum Engl Ed. 1999 Jan 30;66(1 Suppl):37S-39S. Unique Identifier : AIDSLINE MED/99163010
- Breban M; Clinique de Rhumatologie, Hopital Cochin, Universite Rene; Descartes, Paris.
- Interactions of pathogens with the host immune system: implications for the pathogenesis of reactive arthritis.
- Rev Rhum Engl Ed. 1999 Jan 30;66(1 Suppl):60S-61S; discussion 62S. Unique Identifier : AIDSLINE MED/99163015
- Sieper J; Department of Medicine, Rheumatology, Benjamin Franklin Hospital,; Berlin, Germany.
- Transmission routes of HIV-1 gp120 from brain to lymphoid tissues.
- Unique Identifier : AIDSLINE MED/99184836
- Cashion MF; Banks WA; Bost KL; Kastin AJ
- The blood-brain barrier (BBB) restricts the entry of antiviral agents into the CNS thereby facilitating the creation of a reservoir of HIV that could potentially reinfect peripheral tissues. We characterized the efflux from brain of radioactively labeled viral coat HIV-1 gp120 (I-gp120) after intracerebroventricular (
- 9th International Conference on Human Retrovirology HTLV and Related Viruses. Kagoshima, Japan, April 5-9, 1999. Abstracts..
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 1;20(4):A1-88. Unique Identifier : AIDSLINE MED/99226441
- Administration of 9-[2-(R)-(phosphonomethoxy)propyl]adenine (PMPA) to gravid and infant rhesus macaques (Macaca mulatta): safety and efficacy studies.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 1;20(4):323-33. Unique Identifier : AIDSLINE MED/99194239
- Tarantal AF; Marthas ML; Shaw JP; Cundy K; Bischofberger N; California Regional Primate Research Center, Department of; Pediatrics, University of California, Davis 95616-8542, USA.; aftarantal@primate.ucdavis.edu
- 9-[2-(R)-(phosphonomethoxy)propyl]adenine (PMPA) significantly inhibits viral reverse transcription and has been reported to sustain low virus load in SIV-infected rhesus monkeys. Based on these findings, studies were conducted to assess the safety, efficacy, and placental transfer of PMPA when administered once daily
- Human cyclophilin has a significantly higher affinity for HIV-1 recombinant p55 than p24.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 1;20(4):334-6. Unique Identifier : AIDSLINE MED/99194240
- Bristow R; Byrne J; Squirell J; Trencher H; Carter T; Rodgers B; Saman E; Duncan J; Murex Biotech Ltd., Dartford, Kent, UK.; Richard.Bristow@abbott.com
- The ability of cyclophilin to bind a panel of recombinant HIV-gag proteins was assessed using sensitive, quantitative, sandwich enzyme-linked immunosorbant assays (ELISAs). Significantly higher binding to cyclophilin was observed when recombinants contained at least 12 carboxy-terminal amino acids of p17 in addition t
- AIDS-associated Kaposi's sarcoma is more aggressive in women: a study of 54 patients.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 1;20(4):337-41. Unique Identifier : AIDSLINE MED/99194241
- Nasti G; Serraino D; Ridolfo A; Antinori A; Rizzardini G; Zeroli C; Nigro L; Tavio M; Vaccher E; Tirelli U; Division of Medical Oncology and AIDS, Centro di Riferimento; Oncologico, Aviano, Italy.
- OBJECTIVE: To describe the epidemiologic and clinical features of AIDS-associated Kaposi s sarcoma (KS) in women compared with men. METHODS: In a retrospective study, within the Italian Cooperative Group on AIDS and Tumors (GICAT), we compared selected characteristics of 54 women and 108 men with AIDS-associated KS, m
- Trypanosoma cruzi meningoencephalitis in HIV-infected patients.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 1;20(4):342-9. Unique Identifier : AIDSLINE MED/99194242
- Silva N; O'Bryan L; Medeiros E; Holand H; Suleiman J; de Mendonca JS; Patronas N; Reed SG; Klein HG; Masur H; Badaro R; Hospital Espanhol-Bahia, Brazil.
- Five cases of Trypanosoma cruzi meningoencephalitis in HIV-infected patients are reported. All patients presented with mass lesions on head computed tomographic scan, trypanosomes in the cerebrospinal fluid and failure to respond to antitoxoplasmosis therapy. Benznidazole therapy was associated with clinical improveme
- Active anti-interferon-alpha immunization: a European-Israeli, randomized, double-blind, placebo-controlled clinical trial in 242 HIV-1--infected patients (the EURIS study).
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 1;20(4):358-70. Unique Identifier : AIDSLINE MED/99194244
- Gringeri A; Musicco M; Hermans P; Bentwich Z; Cusini M; Bergamasco A; Santagostino E; Burny A; Bizzini B; Zagury D; A. Bianchi Bonomi Hemophilia and Thrombosis Center, Istituto; Ricovero e Cura a Carattere Scientifico Maggiore Hospital and; University of Milan, Italy.
- This randomized, double-blind, placebo-controlled, phase II/III study was designed to evaluate safety, immunogenicity, and efficacy of an active anti-interferon-alpha (anti-IFN-alpha) vaccine in asymptomatic HIV-1-infected patients. The active immunization was aimed at inducing anti-IFN-alpha antibodies to counteract
- Tat toxoid as a component of a preventive vaccine in seronegative subjects.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 1;20(4):371-5. Unique Identifier : AIDSLINE MED/99194245
- Gringeri A; Santagostino E; Muca-Perja M; Le Buanec H; Bizzini B; Lachgar A; Zagury JF; Rappaport J; Burny A; Gallo RC; Zagury D; A. Bianchi Bonomi Hemophilia and Thrombosis Center, Istituto di; Ricovero e Cura a Carattere Scientifico Maggiore Hospital and; State University of Milan, Italy. hemophilia_ctr@polic.cilea.it
- Because administration of Tat protein, the HIV-1 toxin that induces immunosuppression and apoptosis, may be deleterious to the host immune system, a chemically inactivated but nonetheless immunogenic Tat preparation, Tat toxoid, was used to immunize seronegative individuals against Tat. In an open, controlled, phase I
- Estimating AIDS-free survival in a severely immunosuppressed asymptomatic HIV-infected population in the era of antiretroviral triple combination therapy. Swiss HIV Cohort Study.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 1;20(4):376-81. Unique Identifier : AIDSLINE MED/99194246
- Sendi PP; Bucher HC; Craig BA; Pfluger D; Battegay M; Internal Medicine Outpatient Department, University of Basel,; Switzerland.
- BACKGROUND: Antiretroviral triple combination therapies have been evaluated in randomized controlled trials and cohort studies. Little is known about their impact on asymptomatic, severely immunosuppressed, HIV-infected individuals in a real world population. OBJECTIVES: To describe disease progression in a broad asym
- Bacterial vaginosis associated with HIV infection in pregnant women from North Carolina.
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 1;20(4):382-6. Unique Identifier : AIDSLINE MED/99194247
- Royce RA; Thorp J; Granados JL; Savitz DA; University of North Carolina, Chapel Hill 27599, USA.
- BACKGROUND: We investigated whether bacterial vaginosis is associated with HIV infection in pregnant women in North Carolina, U.S.A. METHODS: At 24 to 29 weeks gestation, we recruited 724 women receiving prenatal care to provide interview information and vaginal swabs for Gram s stain scoring of vaginal flora. FINDIN
- Kaposi's sarcoma-associated herpesvirus: a sexually transmissible infection?
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 1;20(4):387-93. Unique Identifier : AIDSLINE MED/99194248
- Grulich AE; Olsen SJ; Luo K; Hendry O; Cunningham P; Cooper DA; Gao SJ; Chang Y; Moore PS; Kaldor JM; National Centre in HIV Epidemiology and Clinical Research,; Sydney, Australia.
- We examined sexual behavior as a risk factor for Kaposi s sarcoma-associated herpesvirus (KSHV) infection and examined the relation between KSHV seropositivity and development of KS in cross-sectional and cohort studies of 130 homosexual men diagnosed with AIDS in Sydney, Australia
- Implication of HTLV-I infection, strongyloidiasis, and P53 overexpression in the development, response to treatment, and evolution of non-Hodgkin's lymphomas in an endemic area (Martinique, French West Indies).
- J Acquir Immune Defic Syndr Hum Retrovirol. 1999 Apr 1;20(4):394-402. Unique Identifier : AIDSLINE MED/99194249
- Agape P; Copin MC; Cavrois M; Panelatti G; Plumelle Y; Ossondo-Landeau M; Quist D; Grossat N; Gosselin B; Fenaux P; Wattel E; Service des Maladies du Sang, Hopital Haut-Leveque, CHU; Bordeaux, France.
- A clinicopathologic study was conducted to assess the implication of HTLV-I infection, Strongyloides stercoralis (Ss) infection, and P53 overexpression in the development, response to treatment, and evolution of non-Hodgkin s lymphoma (NHL) in