[P3] NO EVIDENCE OF HYPERLIPIDAEMIA OR LIPODYSTROPHY WITH NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR (NNRTI)-OR NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR (NRTI)-BASED REGIMENS IN AN ETHNICALLY DIVERSE POPULATION

8th Annual Conference Of The British HIV Association [BHIVA]

19 – 21 April 2002, University of York, York

[TITLE:] NO EVIDENCE OF HYPERLIPIDAEMIA OR LIPODYSTROPHY WITH NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR (NNRTI)-OR NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR (NRTI)-BASED REGIMENS IN AN ETHNICALLY DIVERSE POPULATION

[AUTHOR(S):] L Hodgson¹, C Hodgson², S Murad², J Herman², C Taylor², P Easterbrook², D Macallan¹
¹ St George's Hospital and ² King's College Hospital, London

BHIVA Conf 2002 Apr 19-21;8:P3

OBJECTIVE: To determine the incidence of hyperlipidaemia and lipodystrophy in an ethnically diverse population of antiretroviral-naïve patients who received NNRTI- or NRTI-based regimens.

METHODS: Eligible patients were treatment-naïve HIV-positive individuals attending King's College and St George's Hospitals and about to commence highly active antiretroviral therapy (HAART). A standardized questionnaire was used to collect data on demographic, lifestyle and cardiovascular risk factors. An anthropometric and dietary assessment was also performed, with selected laboratory measures including cholesterol, triglycerides, high- and low-density lipoprotein cholesterol at baseline and 3, 6, 9 and 12 months after starting HAART.

RESULTS: 64 patients have been enrolled to date. 60.9% were men, 42.2% were black African, 34.4% were white, and 15.6% were black Caribbean. The median age at evaluation was 35.4 years and the CD4 count and viral load were 177 cells/μL and 78,522 copies/mL, respectively; 65.6%, 13.5% and 18.7% of patients began efavirenz-, nevirapine- or triple NRTI-based regimens, respectively. We analysed patients with anthropometric and lipid data at baseline and at least one follow-up visit (≥3 months). Although there was an overall significant gain in weight (P=0.006) the change in anthropometric indices (upper arm, waist and hip circumferences; triceps, biceps and supra-iliac skinfold thicknesses) were not consistent with lipodystrophy during follow-up.

CONCLUSIONS: We confirmed an absence, over the short-term, of lipid or body habitus changes in this ethnically diverse population with non- PI-containing regimens.

PRESENTING AUTHOR: C Hodgson

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