9th Annual Conference Of The British HIV Association [BHIVA] 24 – 26 April 2003, University of Manchester Institute of Science & Technology (UMIST) Manchester

[AUTHOR(S):] GP Taylor¹, L Sarner², W Khan³, L Navaratne⁴, D Mercey⁵, EGH Lyall⁶, A Fakoya², D Hawkins³ and A de Ruiter⁴
Imperial College¹, Newham Healthcare NHS Trust², Chelsea and Westminster Hospital³, St Thomas’s Hospital⁴, Mortimer Market Centre⁵ and St Mary’s Hospital⁶, London, UK

BHIVA Conf 2003 Apr 24-26;9:O1

BACKGROUND: The number of HIV-infected women becoming pregnant in the UK has increased dramatically over the last few years. Few studies have addressed the long-term outcome of these women. We have therefore initiated a multicentre, prospective cohort study of pregnant women in London.

METHODS: Chart review of all women diagnosed HIV positive ante partum in five London centres between 01/1998 and 12/2001 with follow up recorded prospectively.

RESULTS: 218 women delivered, 24 in 1998, 48 in 1999, 67 in 2000 and 79 in 2001. 180 were black African, 25 were European of which 4 were or had been injecting drug users. Mean age at delivery was 30.2 years. First antenatal clinic visit: CDC status A 164, B 24, C 16; mean CD4 count 345 cells/µl, median viral load (VL) 4780 copies/ml. 42 mothers were already on triple therapy (group I) CD4 204, VL <50. 58 mothers took zidovudine monotherapy (group II), CD4 435, VL 2238. 103 commenced triple therapy (group III), CD4 288, VL 14820. The mean follow-up (FU) is 20.5 months. During 347 person-years of follow-up, three women have had an AIDS-defining infection, one from each group. All were African, had CD4 counts >200 and two had tuberculosis. Only one group II mother has started triple therapy (ART) post-partum but only 74 women remained on ART at last FU; 43 women discontinued triple therapy within 1 month of delivery. Mean CD 4 count of the cohort at last FU was 437 cells/µl. Group III n = 469, group II 535, group III 449.

CONCLUSIONS: These data demonstrate good maternal health for up to 4 years following the management of HIV infection in pregnancy.

PRESENTING AUTHOR: EGH Lyall

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Copyright © 2003 - British HIV Association (BHIVA) Reproduction of this abstract (other than one copy for personal reference) must be cleared through the BHIVA Organising Secretariat 1 Mountview Court, 310 Friern Barnet Lane, London N20 0LD