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9th Annual Conference Of The British HIV Association [BHIVA]24 – 26 April 2003, University of Manchester
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[AUTHOR(S):] EGH Lyall, C Foster, D Melvin and R Biggs
Family Clinic, Department of Paediatrics, St Mary's Hospital, London, UK
BHIVA Conf 2003 Apr 24-26;9:O5
BACKGROUND: Even with improved prognosis for HIV-infected children, developmental monitoring remains important.
AIM: To compare neurological and early developmental outcome of two groups of children, group 1 presenting with severe HIV disease other than encephalopathy (category C, CDC Classification 1994) and group 2 presenting with mild/moderate disease (category A/B).
METHODS: Systematic evaluations of neurological and developmental functions, with neurological examination by a paediatric physiotherapist and paediatrician. Development was assessed using the Bayley Scales of Infant Development II by a clinical psychologist and paediatric physiotherapist.
RESULTS: Neurology: group 1 (n=32), mean age at assessment 16 months (range 7–26), 43% (13/32) had abnormal neurological signs, mostly spastic diplegia. Group 2 (n=31), mean age at assessment 18 months (8–33), 7% (2/31) had abnormal neurological signs, both mild diplegia (χ2 P<0.05). Developmental scores: 20% of group 1 and 61% of group 2 scored within the average range (+1 to -1 SD score) in both mental and motor functions (χ2 P<0.05). Group 2 scores were more normally distributed around the mean; in group 1 a higher number of children had scores of over -3 SD.
CONCLUSIONS: Severe early HIV disease is related to abnormal neurology with motor impairment and developmental delays. Our results emphasise the need for regular developmental monitoring and have implications for community services.
PRESENTING AUTHOR: R Biggs
030424
O5
Copyright © 2003 - British HIV Association (BHIVA) Reproduction of this abstract (other than one copy for personal reference) must be cleared through the BHIVA Organising Secretariat 1 Mountview Court, 310 Friern Barnet Lane, London N20 0LD