10th Anniversary Conference Of The British HIV Association [BHIVA] 15 – 17 April 2004, City Hall, Cardiff, UK

[AUTHOR(S):] GP Taylor¹, W Khan², L Navaratne³, F Martin⁴, L Sarner⁵, D Mercey⁶, J Anderson⁴, A Fakoya⁵, DA Hawkins², A de Ruiter^3
1 St Mary's Hospital, ² Chelsea and Westminster Hospital, ³ St Thomas' Hospital, ⁴ Homerton University NHS Trust, ⁵ Newham Healthcare NHS Trust, ⁶ Mortimer Market Centre, London, UK

BHIVA Conf 2004 Apr 15-17;10:O26

BACKGROUND: Perception of long-term prognosis may influence family planning decisions by HIV-positive women but few studies have investigated the disease-free survival of HIV-infected women following pregnancy.

METHODS: Notes were reviewed for all women diagnosed HIV seropositive ante-partum between the start of 1998 and the end of 2002 in six centres. Data were analysed by χ2- and t-test.

RESULTS: 350 women delivered 362 babies; 84% were black African, 10% European and 4% Afro-Caribbean. The only HIV-infection risk in 96.5% was heterosexual intercourse. Compared with women treated with three or more drugs (combination antiretroviral therapy, CART), the 94 women treated with zidovudine monotherapy were younger (mean 28.7 versus 31.1 years, P<0.05) had higher CD4 lymphocyte counts (median 460 versus 282 cells/µl, P<0.05) and lower HIV loads (median 2279 versus 7800 HIV RNA copies/ml plasma, P<0.05). At the last follow-up (mean 26.7 months post-partum), there was no significant difference in CD4 lymphocyte counts (median 484 on monotherapy versus 428 on CART). During 711 person-years of followup, five women treated in pregnancy with CART (564 person-years) and one given monotherapy (147 person-years) had an AIDS-defining illness (ADI), but all six women currently have CD4 counts >200 cells/µl.

CONCLUSION: Good immune function is documented up to 5 years post-partum in this cohort with a low incidence of ADIs.

PRESENTING AUTHOR: F Martin

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Copyright © 2004 - British HIV Association (BHIVA) Reproduction of this abstract (other than one copy for personal reference) must be cleared through the BHIVA Organising Secretariat 1 Mountview Court, 310 Friern Barnet Lane, London N20 0LD