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10th Anniversary Conference Of The British HIV Association [BHIVA]15 – 17 April 2004, City Hall, Cardiff, UK |
[AUTHOR(S):] S Shah, CJ Smith, FC Lampe, MS Youle, MA Johnson, AN Phillips, CA Sabin
Royal Free and University College Medical School and Royal Free Hospital, London, UK
BHIVA Conf 2004 Apr 15-17;10:P2
INTRODUCTION: While haemoglobin was strongly associated with disease progression and death pre-HAART, its role in patients receiving HAART is unclear.
METHODS: Changes in haemoglobin were investigated in 645 antiretroviral-naïve patients from the Royal Free Hospital who started HAART between 1996 and 2003. Relationships between haemoglobin levels and disease progression were investigated using Cox models.
RESULTS: Median pre-HAART haemoglobin levels were 13.8 g/dl in men and 11.4 g/dl in women. Levels were significantly lower in women (P<0.0001) and in those of non-white ethnicity (P=0.002), and were positively correlated with the CD4 count (P<0.0001) and negatively with age (P=0.0005). Although there was little overall change in haemoglobin levels 1 year after HAART, women had a 1.29 g/dl greater increase in Hb than men (P<0.0001); increases were also related to age, risk group and pre-HAART haemoglobin levels. There was a decline in anaemia in both sexes (P<0.0001). Haemoglobin changes were correlated with changes in the CD4 count over 1 year. Time-updated haemoglobin was related to time to AIDS/death (hazard ratio 0.59, P<0.0001), independently of the CD4 count (0.59, P<0.0001) and a previous AIDS diagnosis (0.49, P<0.002). The prognostic value of haemoglobin did not differ by sex.
CONCLUSIONS: Haemoglobin changes following HAART vary by sex, age and risk group, but remain significantly associated with prognosis in both sexes.
PRESENTING AUTHOR: S Shah
040415
P2
Copyright © 2004 - British HIV Association (BHIVA) Reproduction of this abstract (other than one copy for personal reference) must be cleared through the BHIVA Organising Secretariat 1 Mountview Court, 310 Friern Barnet Lane, London N20 0LD