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11th Annual Conference Of The British HIV Association [BHIVA]20–23 April 2005, Burlington Hotel·Dublin·Ireland |
[AUTHOR(S):] W Ferguson2, K Butler1,2,3, A Menon3 , M Goode1, L Barrett1, A Walsh1, M Cafferkey2,3
1The Rainbow Clinic, National Centre for HIV Medicine in Children, Our Lady’s Hospital for Sick Children, 3The Children's University Hospital and 2The Rotunda Hospital, Dublin, Ireland
BHIVA Conf 2005 Apr 20-23;11:O10
AIM: 'Opt-out' AN screening, in Ireland since Jan.'99, has 95%–99% uptake. Vertical transmission rates are <2%. We sought to identify intervention targets to reduce ongoing transmission.
METHODS: HIV+ pregnant women are referred to the paediatric service. Maternal and infant data are prospectively gathered.
RESULTS: From 01/1999–12/2004, 11 infected infants were born. There were 527 HIV+ pregnancies and 2 postnatal diagnoses. 2/11 infants were born to the women diagnosed postnatally (1 pregnancy seroconversion, 1 missed screening). Of the remaining 9, 4/9 women who booked at (36 weeks received ≤3 weeks ART. 5/9 booked <36 weeks; 1 received <1 week ART & delivered at 33 weeks. 4 received >4 weeks ART (3 cART, 1 ZDV); adherence was poor in 1 (delivery VL >10,000 copies/ml), 1 with undetectable VL had 24 hours ROM, in the remaining 2 (1 ZDV monotherapy & delivery viral load <400 copies/ml, 1 cART from 20/40 & delivery VL 53 copies/ml), infant HIV-PCRs were positive ≤5 days suggesting in-utero transmission. All 9 women & infants received IP-ZDV and postnatal ART respectively (6 triple, 3 monotherapy).
CONCLUSIONS: There remain identifiable targets for intervention (pre-conceptual screening, early booking, repeat tests for at-risk women, adherence support). The problem of early in-utero transmission remains.
PRESENTING AUTHOR: W Ferguson
2005-04-20
O10
Copyright © 2005 - British HIV Association (BHIVA) Reproduction of this abstract (other than one copy for personal reference) must be cleared through the BHIVA Organising Secretariat 1 Mountview Court, 310 Friern Barnet Lane, London N20 0LD