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11th Annual Conference Of The British HIV Association [BHIVA]20–23 April 2005, Burlington Hotel·Dublin·Ireland |
[AUTHOR(S):] MY Tung, AK Sullivan, S Mandalia, MR Nelson, BG Gazzard
St Stephen's Centre, Chelsea and Westminster Hospital, London, UK
BHIVA Conf 2005 Apr 20-23;11:O21
AIM: Evaluate virological and immunological responses to HAART.
METHODS: 12 month treatment outcome was defined as successful (TS=VLBLD+>50CD4 cell rise), discordant immunological response(DIR=VLBLD+<50CD4 cell rise), discordant virological response(DVR=+VL+ >50CD4 cell rise) and failing (TF=+VL+<50CD4 cell rise). 24 month data and disease progression were obtained.
RESULTS:
| All | TS | DIR | DVR | TF | P= | |
| Number(%) | 1141 | 757(66.4) | 186(16.3) | 98(8.6) | 100(8.8) | |
| Baseline CD4(cells/µL) | 175 | 157 | 264 | 151 | 225 | <0.001 |
| VL(copies/ml) | 71,138 | 88,792 | 29,791 | 101,818 | 67,091 | <0.001 |
| Rate of CD4 decline | 9.7 | 4.8 | 9.5 | 4.7 | <0.001 | |
| preHAART | [9.1–10.3] | [3.7–6.0] | [7.9–11.0] | [3.3–6.2] | ||
| (cells/mL/month[95%CI]) | ||||||
| 24 month outcome N(%) | 755 | 548(72.6)* | 85(11.3) | 65(8.6) | 57(7.5) | *<0.05 |
| Disease Progression(%) | 6.3 | 4.6* | 8.9* | 4.2 | 9.4 | *0.02 |
CONCLUSIONS: 24.9% experience DR at 12 months, affected by age, CD4 count, VL and rate of CD4 decline. DIR and DVR have a good treatment outcome at 24 months. <50 CD4 rise is more predictive of DP than a positive VL.
PRESENTING AUTHOR: MY Tung
2005-04-20
O21
Copyright © 2005 - British HIV Association (BHIVA) Reproduction of this abstract (other than one copy for personal reference) must be cleared through the BHIVA Organising Secretariat 1 Mountview Court, 310 Friern Barnet Lane, London N20 0LD