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11th Annual Conference Of The British HIV Association [BHIVA]20–23 April 2005, Burlington Hotel·Dublin·Ireland |
[AUTHOR(S):] J Turner1, S Hopkins2, T Mahungu2, R Johnstone1, RM Lascar1,3, S Bhagani2, G Dusheiko, MA Johnson2, I Williams1,3, RJC Gilson1,3
1Centre for Sexual Health and HIV Research, Royal Free and University College Medical School, 2Department of HIV Medicine, Royal Free Hospital, 3Camden PCT, Mortimer Market Centre, London, UK, Centre for Hepatology, Royal Free Hospital, London, UK
BHIVA Conf 2005 Apr 20-23;11:O27
INTRODUCTION: Response rates of 26–46% have been reported to p-IFN and RBV in HIV-HCV in published studies. None of these studies have investigated the role of nadir CD4 count in predicting response.
AIM: to evaluate treatment outcomes and predictors of response, particularly nadir CD4 counts
METHODS: All HIV-HCV patients (n=59) who commenced treatment for chronic HCV at two centres were included in this analysis. Baseline demographics, HCV and HIV related factors were collated. Data was entered and analysed on SPSSv10.0.
RESULTS: Patients were predominantly male (86%), Caucasian (87%), and on antiretrovirals (ARV) (69%). 32% were IVDU and 39% were MSM. 44% were genotype 2/3. Median age was 40 yrs, baseline CD4 count was 468x106/l and nadir CD4 count was 220×106/l. Median baseline HCV-VL was 1.5X106IU/l. 56% had an end-of-treatmentresponse (Genotype (G) 1/4:33% & G2/3:86%) and 42% had a SVR (G1/4:24%&G2/3:65%). Predictors of response were nadir CD4 count (P=0.04) and genotype(P=0.008). No other factors predicted response including age, sex, type of p-IFN (2A/2B) or duration of HCV therapy. 19% discontinued therapy.
CONCLUSIONS: This analysis demonstrates SVRs comparable to controlled studies in HIV-HCV co-infected patients. In addition to genotype, nadir CD4 predicted response to HCV therapy. This merits investigation in larger datasets.
PRESENTING AUTHOR: S Hopkins
2005-04-20
O27
Copyright © 2005 - British HIV Association (BHIVA) Reproduction of this abstract (other than one copy for personal reference) must be cleared through the BHIVA Organising Secretariat 1 Mountview Court, 310 Friern Barnet Lane, London N20 0LD