11th Annual Conference Of The British HIV Association [BHIVA] 20–23 April 2005, Burlington Hotel·Dublin·Ireland

[AUTHOR(S):] A Dunleavy¹, RAM Breen¹, A Bybee², S Hopkins¹, PN Hawkins², M Lipman^1
1Royal Free Hospital, London, ²The National Amyloid Centre, Royal Free Hospital, London, UK

BHIVA Conf 2005 Apr 20-23;11:O30

AIMS: The inflammatory condition FMF is associated with polymorphisms in the human pyrin gene. Its expression is upregulated by cytokines similar to those implicated in TB related PR. We sought to ascertain if patients with these polymorphisms are at an increased risk of PR compared to HIV + subjects (known risk factor for PR

METHODS: MEFV exon 2 restriction length polymorphism for Q148 was analysed in blood from subjects with active TB enrolled in a prospective study of PR. Analysis was performed using SPSS 10.0.

RESULTS: 42 subjects were assessed – 17 (41%) HIV+. (24%) experienced PR. 9/42 (21%) expressed the Q148 mutation of which 4/10 (40%) had PR. 5/32 (16%) without PR were Q148 mutation+ (P=0.18). PR occurred in 5/17 (29%) HIV- and 5/25 (20%) HIV-subjects (P=0.71). The odds ratio (OR) for developing PR with Q148 was 3.6 (95%CI 0.40-7.0; P=0.48).

CONCLUSIONS: In our cohort PR appeared to be more strongly associated with Q148 polymorphisms than HIV status. This requires confirmation in a larger study.

PRESENTING AUTHOR: A Dunleavy

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2005-04-20
O30

Copyright © 2005 - British HIV Association (BHIVA) Reproduction of this abstract (other than one copy for personal reference) must be cleared through the BHIVA Organising Secretariat 1 Mountview Court, 310 Friern Barnet Lane, London N20 0LD