12th Annual Conference of the British HIV Association 29 March–1 April 2006, Brighton, UK

METABOLIC SYNDROME AND ITS ASSOCIATIONS IN HIV PATIENTS

HIV Med 2006; 7(Suppl. 1):5 (abstract no. O18)

Ali Elgalib¹, George Panayotakopoulos², Michael Aboud¹, Elias Skopelitis², Kathryn Ludgate¹, Alice Sharpe², Fiona Lampe³, Allaister Duncan¹, Ranjibabu Kulasegaram¹, Anthony Wierzbicki¹ and Barry Peters^2
1 Guy’s and St Thomas’ NHS Foundation Trust, ² Academic Unit of HIV and STDs, St Thomas’ site of King’s College London, ³ The Department of Population Sciences at Royal Free site of University College London, London, UK

OBJECTIVES: To estimate the prevalence and associations of metabolic syndrome (MS) in an HIV cohort.

METHODS: Prospective longitudinal cohort study. Observations thus far obtained from 200 patients include demographics, disease stage, details of HAART and incidence of MS. The national Cholesterol Education Program definition of MS was used. This requires the presence of three or more of the following: high blood pressure, high fasting glucose, low HDL cholesterol, high fasting triglycerides and abdominal obesity. Data was analysed on Excel spreadsheet and P-value was obtained using Mann-Whitney/Wilcoxon Two sample test.

RESULTS: Complete data on MS was available on 128/200 patients. Median age 39.5, 76.6% were male, 23.4% female, 51.6% Caucasian, 49.4% non-Caucasian (32% African). The prevalence of MS was 9.4% (12/128). For those who had MS, 75% were male, 58.3% Caucasian, 41.7% non-Caucasian (33.3% African), 58.3% were on HAART, 28.6% on Protease Inhibitors (PI) and 16.7% had AIDS. Regarding those who did not have MS, 76.6 % were male, 50.9% Caucasian, 49.1% non-Caucasian (31.9% African), 19.1% had AIDS, 73.3 % on HAART, 45.2% on PI. The median age for the patients with MS was 46.5, compared to 39.0 in non-metabolic syndrome arm (P-value 0.0037).

CONCLUSION: The patients with MS tend to be male and of a higher age group. There seems to be no effect of stage of disease or, surprisingly, the type of HAART on the incidence of MS. Our data showed that prevalence of MS among HIV patients is less than what has been reported previously, but this might be partly because of an under-reporting bias which will be corrected as missing data are retrieved.

2006-03-29
O18

Copyright © 2006 - British HIV Association (BHIVA) Reproduction of this abstract (other than one copy for personal reference) must be cleared through the BHIVA Organising Secretariat 1 Mountview Court, 310 Friern Barnet Lane, London N20 0LD