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12th Annual Conference of the British HIV Association29 March–1 April 2006, Brighton, UK |
VIRAL REBOUND IN PATIENTS ON ANTIRETROVIRAL THERAPY WITH VIRAL SUPPRESSION: ASSOCIATION WITH EXTENT OF PREVIOUS VIROLOGICAL FAILURE AND TIME WITH VIRAL SUPPRESSION
HIV Med 2006; 7(Suppl. 1):3 (abstract no. O9)
Andrew A Benzie1, Loveleen K Bansi2, Caroline A Sabin2, John Walsh1 and Andrew N Phillips2 on behalf of the UK CHIC Study
1St Mary’s Hospital, London, 2Royal Free and University College Medical School, London, UK
BACKGROUND: Few data are available on the association between use of antiretroviral regimens and rates of viral rebound in those attaining a viral load (VL) of <50 copies/ml while receiving highly active antiretroviral therapy (HAART).
AIMS:To determine whether the rate of viral rebound decreases with increasing duration of viral suppression in patients who have failed one or more antiretroviral regimens, and if so whether with sufficient time the rebound rate declines to as low as that observed in patients on first-line therapy.
METHOD: Patients achieving a VL<50 copies/ml for the first time while receiving HAART were followed until viral rebound (two consecutive VLs>400 copies/ml).
RESULTS: 10,243 patients from the UK Collaborative HIV Cohort (UK CHIC) achieved a VL<50 copies/ml whilst on HAART. Virological rebound rates per 100 person-years (p-years).
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| Duration of viral suppression to ≤50 copies/ml (p-years) |
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| Number of regimens previously failed | <1 | 1-2 | 2-3 | 3-4 | >4 |
| 0 | 8.4 | 5.2 | 4.1 | 3.1 | 3.0 |
| 1 | 18.0 | 11.1 | 7.1 | 4.4 | 2.3 |
| 2 | 22.2 | 13.1 | 10.7 | 4.7 | 4.3 |
| 3 | 27.7 | 12.8 | 8.9 | 5.3 | 4.6 |
| 4 | 29.7 | 9.9 | 6.5 | 11.4 | – |
| >5 | 41.9 | 19.3 | 5.5 | 11.3 | 8.1 |
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CONCLUSION: The rate of viral rebound diminishes markedly with increasing time with viral suppression, especially in those who have failed previous regimens.
2006-03-29
O9
Copyright © 2006 - British HIV Association (BHIVA) Reproduction of this abstract (other than one copy for personal reference) must be cleared through the BHIVA Organising Secretariat 1 Mountview Court, 310 Friern Barnet Lane, London N20 0LD