12th Annual Conference of the British HIV Association 29 March–1 April 2006, Brighton, UK

DOES GENDER OR ETHNICITY INFLUENCE TREATMENT OUTCOMES IN ANTIRETROVIRAL-NAÏVE PATIENTS COMMENCING NNRTI-BASED HAART?

HIV Med 2006; 7(Suppl. 1):12 (abstract no. P7)

Naa-Torshie Annan, Sundhiya Mandalia, Mark Bower, Brian Gazzard and Mark Nelson
Chelsea and Westminster Hospital NHS Trust, London, UK

AIMS: To determine whether gender and ethnicity are associated with time to virological success or treatment failure in ART-naïve patients commencing HAART.

METHODS: ART-naïve individuals commencing efavirenz (EFV) or nevirapine (NVP) with dual NA backbone were identified between 1/1/1998 and 1/7/2004 from a prospectively collected database. Virological success was defined as VL<500 copies/ml. Treatment failure was switch/discontinuation of NNRTI or documented virological failure (2 × VL >500 copies/ml).

RESULTS: Nine hundred and ninty-four patients were identified; 85.8% male and 69.1% Caucasians. 72.7% commenced EFV and 27.3% NVP-containing HAART. There was no difference between the two treatment groups for age and ethnicity, although significantly more females commenced NVP while the converse was true for males (P<0.001). In univariate analysis, neither gender nor ethnicity (black Africans versus Caucasians) were associated with time to virological success (P=0.299 and P=0.322 respectively) or time to treatment failure (P=0.703 and P=0.499 respectively).

CONCLUSION: We have shown that in a large NNRTI-experienced cohort there is no significant difference for gender or ethnicity with respect to time to virological success or treatment failure.

2006-03-29
P7

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