5th Conference on Retroviruses and Opportunistic Infections Chicago, IL - February 1-5, 1998

Conf Retroviruses Opportunistic Infect 1998 Feb 1-5; 5th:83 (abstract no. 22)

Sachsenberg N, Perelson A, Perrin L; Laboratory of Virology, University Hospital, Geneva, Switzerland.

Measures of CD4 and CD8 turnover in HIV-infected individuals have been based on dynamics of CD4 recovery following antiviral therapy or telomere length. We have selected another approach based on the detection of Ki-67 antigen + cells. The mean percentage of Ki-67+ cells in healthy controls (n=23) is 1.1% for CD4 and 1% for CD8; these levels increased in HIV-infected individuals (n=42) to 6.5% for CD4 and 4.3% for CD8. The mean potential doubling time is 156 days for CD4 and 167 days for CD8 in healthy controls vs 27 and 36 days in HIV-1 infected individuals. This corresponds in healthy controls to a turnover of 1.5 x 10(9) cells/day for CD4 and 0.7 x 10(9) cells/day for CD8. HIV-infected individuals have a mean 2-fold increase in CD4 turnover, with wide inter-individual variations; mean CD4 turnover is higher than in controls in patients with CD4 greater than 50/mm³ (3.55 x 10(9) cells/day) and decreased in the 9 patients with CD4 less than 50/mm³ (0.42 x 10(9) cells/day). In contrast, a mean 7-fold increase in CD8 turnover is observed in HIV-infected individuals, independently of CD4 levels. Our results indicate that the regenerative capacity of CD4 and CD8 cells is preserved until late stage disease.

1998-02-01
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Copyright © 1998 - Foundation for Retrovirology and Human Health (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Foundation for Retrovirology and Human Health. Licensed from National Library of Medicine.