AEGiS-05CROI: The effect of polymorphisms in the regulatory regions of the CCR5 promoter on HIV-1 vertical transmission and on disease progression in infected children.

5th Conference on Retroviruses and Opportunistic Infections


Chicago, IL - February 1-5, 1998



The effect of polymorphisms in the regulatory regions of the CCR5 promoter on HIV-1 vertical transmission and on disease progression in infected children.

Conf Retroviruses Opportunistic Infect 1998 Feb 1-5; 5th:229 (abstract no. S3)

Moore JP, Kostrikis LG, Ho DD; Aaron Diamond AIDS Research Center, New York, NY.

Expression levels of the CCR5 co-receptor on activated CD4+ T-cells are known to vary considerably (around 20-fold) among individuals who have wild-type CCR5 coding sequences (Moore JP. Science 276, 51-52, 1997). Heterozygosity for the protein coding-defective d32-CCR5 allele has a significant delaying effect on disease progression in infected adults, but only causes about a 2-fold reduction in CCR5 expression. Hence it was a reasonable assumption that the non-coding factors which more substantially influence CCR5 expression would also influence disease progression, and perhaps the efficiency of HIV-1 transmission. We have now identified several mutations in and around the twin promoters of the CCR5 gene. The effect of these multiple polymorphisms on the efficiency of HIV-1 vertical transmission and on the rate of disease progression in infected children will be described, as will the way in which they influence CCR5 expression levels on CD4+ T-cells in vitro. We will also describe the impact of the CCR2-64I allele on vertical transmission and disease progression, and present information relevant to its mechanism of action.

Keywords: AEGIS, Disease Transmission, Vertical, HIV-1, Regulatory Sequences, Nucleic Acid, Receptors, CCR5, Disease Progression, Promoter Regions (Genetics), Polymorphism (Genetics), Alleles, Anti-HIV Agents, Mutation, Antigens, CD4, Child, Human, Adult, In Vitro, transmission, genetics, AIDS

1998-02-01
S3

Copyright © 1998 - Foundation for Retrovirology and Human Health (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Foundation for Retrovirology and Human Health. Licensed from National Library of Medicine.