AEGiS-05CROI: Infection of macrophages by primary, syncytium-inducing HIV-1 strains: the role of CCR5, CXCR4 and other coreceptors.

5th Conference on Retroviruses and Opportunistic Infections


Chicago, IL - February 1-5, 1998



Infection of macrophages by primary, syncytium-inducing HIV-1 strains: the role of CCR5, CXCR4 and other coreceptors.

Conf Retroviruses Opportunistic Infect 1998 Feb 1-5; 5th:229 (abstract no. S4)

Clapham PR, Simmons G; Section of Virology, Institute of Cancer Research, London, United Kingdom.

Syncytium inducing (SI) HIV-1 strains usually emerge late in disease and are associated with a faster decline in CD4+ T-cell numbers. The switch to an SI phenotype results from adaptation to use of the CXCR4 coreceptor for entry into cells. CXCR4 is expressed on a wide variety of cell types including macrophages as well as T-cells, however the efficiency of macrophage infection by primary SI strains is controversial. A panel of SI viruses with different capacities for macrophage infection have been characterized for their ability to use a range of different coreceptors expressed on CD4+ cell lines. The same viruses were assessed for infection of deltaccr5/deltaccr5 macrophages and their sensitivity to inhibition by a range of ligands specific for different co-receptors. We show that CXCR4 alone can be used by primary SI strains, for infection macrophage cultures, while others use either CCR5 or CXCR4. The implications of these results for HIV tropism and transmission will be discussed.

Keywords: AEGIS, HIV-1, Giant Cells, Macrophages, Antigens, CD4, Anti-HIV Agents, Cell Line, T-Lymphocytes, AIDSKWDaegis,hiv-1,giantcells,macrophages,antigens,cd4,anti-hivagents,cellline,t-lymphocytes,aids

1998-02-01
S4

Copyright © 1998 - Foundation for Retrovirology and Human Health (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Foundation for Retrovirology and Human Health. Licensed from National Library of Medicine.