AEGiS-05CROI: Chemokines in atherosclerosis, inflammation, and AIDS.

5th Conference on Retroviruses and Opportunistic Infections


Chicago, IL - February 1-5, 1998



Chemokines in atherosclerosis, inflammation, and AIDS.

Conf Retroviruses Opportunistic Infect 1998 Feb 1-5; 5th:230 (abstract no. S5)

Author; Author

Chemokines are small, basic peptides that induce directed migration of leukocytes. The receptors for all known leukocyte chemoattractants, including the chemokines, are members of the seven-transmembrane domain superfamily, and have been shown to couple to a variety of G-protein alpha-subunits. An exciting, and unexpected role for chemokine receptors in mediating entry of HIV-1 into cells have recently been established for several chemokine receptors, including CCR5 and CXCR4. In today's presentation I will provide an overview of the rapidly expanding family of chemokines, and discuss our laboratory's work on two chemokine receptors: CCR2, the receptor for monocyte chemoattractant 1 (MCP-1), and CCR5, the major coreceptor for M-tropic viruses. I will present data on the signaling pathways utilized by chemokine receptors initiating chemotaxis, and will discuss the role of receptor signaling in the HIV-1 coreceptor activity of CCR5. Finally, I will give a progress report on our characterization of the CCR2 knockout mouse we have created.

Keywords: AEGIS, Chemokines, Acquired Immunodeficiency Syndrome, Receptors, Chemokine, HIV-1, Inflammation, Monocyte Chemoattractant Protein-1, Arteriosclerosis, Anti-HIV Agents, Leukocytes, Signal Transduction, Chemotaxis, Animal, Mice, AIDSKWDaegis,chemokines,acquiredimmunodeficiencysyndrome,receptors,chemokine,hiv-1,inflammation,monocytechemoattractantprotein-1,arteriosclerosis,anti-hivagents,leukocytes,signaltransduction,chemotaxis,animal,mice,aids

1998-02-01
S5

Copyright © 1998 - Foundation for Retrovirology and Human Health (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Foundation for Retrovirology and Human Health. Licensed from National Library of Medicine.