AEGiS-05CROI: Unwelcome guests with master keys: how HIV-1 used chemokine receptors to infect cells.

5th Conference on Retroviruses and Opportunistic Infections

Chicago, IL - February 1-5, 1998

Unwelcome guests with master keys: how HIV-1 used chemokine receptors to infect cells.

Conf Retroviruses Opportunistic Infect 1998 Feb 1-5; 5th:230 (abstract no. S6)

Dorns RW; University of Pennsylvania, Philadelphia, PA.

HIV-1, HIV-2, and SIV use certain chemokine receptors in conjunction with CD4 to infect cells. Differential utilization of these receptors by virus strains as well as where the receptors are expressed in vivo largely explain viral tropism at the level of entry. M-tropic HIV-1 virus strains use CCR5, while T-tropic strains use CXCR4. By contrast, all or nearly all SIV strains use CCR5 but not CXCR4 for cellular entry. Topics to be discussed during this presentation include work on the CCR2b polymorphism that is associated with delayed progression to AIDS; CCR5-dependent, CD4-independent infection of brair capillary endothelial cells by neurotropic SIV strains; use of orphan receptors for cellular entry by HIV-1 and SIV; coreceptor structure-function studies; coreceptors used by a pathogenic SHIV; and studies on the chemokine MDC.

Keywords: AEGIS, Receptors, HIV, Receptors, Chemokine, Chemokines, SIV, HIV-2, Antigens, CD4, HIV-1, Simian Acquired Immunodeficiency Syndrome, Tropism, Cells, Macrophage Inflammatory Protein-1, Anti-HIV Agents, Macrophages, Acquired Immunodeficiency Syndrome, CD4-Positive T-Lymphocytes, Cell Line, pathogenicity, AIDS

1998-02-01
S6

Copyright © 1998 - Foundation for Retrovirology and Human Health (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Foundation for Retrovirology and Human Health. Licensed from National Library of Medicine.