7th Conference on Retroviruses and Opportunistic Infections


San Francisco, CA - January 30 -February 4, 2000



CANCER INCIDENCE AMONG HIV-INFECTED MEN AND WOMEN IN SOUTHERN EUROPE.

Conf Retroviruses Opportunistic Infect 2000 Jan 30-Feb 2; 7:77 (abstract no. 11)

D. Serraino, A. Boschini, C. Pradier, M. Dorrucci, P. Carrieri, P. Ballarini, G. Ippolito, And G. Rezza
IRCCS L, Spallanzani, Rome, Italy.

BACKGROUND: Studies from North America, Australia and Europe have evidenced an excess of several cancer types, in addition to KS and NHL, among HIV-infected individuals. For some cancer sites, however, the results were not consistent. To assess the spectrum of malignancies associated with HIV infection in Southern Europe, longitudinal data from a cohort of HIV seroconventers and from two HIV seroprevalent cohorts in Italy and France were combined and analysed.

METHODS: 5,281 HIV-positive men (3,422 IDU, 1,365 homosexuals and 494 heterosexuals) were followed up for 19,609 person-years (PY), and 2,141 HIV-positive women (1,340 IDU and 801 heterosexuals) were followed-up for 9,070 PY. The number of observed cases was compared with the expect one, based on age- and sex-specific incidence rates in the general population of Italy or France. Age-standardised incidence ratios (SIR), and their 95% confidence intervals (CI) were computed.

RESULTS: Among HIV-positive males, significantly increased SIR emerged for liver cancer (SIR=18.6), Hodgkin's disease (HD) (SIR=11.2), and lung cancer (SIR=3.6). When the totality of non-AIDS-defining cancers was considered, a 2-fold higher risk emerged (95% CI: 1.4-2.9). Among women, a particularly elevated risk for invasive cervical cancer (ICC) was evident among IDU (SIR=16.7, 95% CI: 5.2-28.2).

CONCLUSION: These results confirm previous studies showing an excess of HD and ICC among HIV-positive individuals, and they suggest that liver and lung cancers' risks may also be increased as a consequence of HIV.

Keywords: AEGIS, Incidence, Neoplasms, Acquired Immunodeficiency Syndrome, HIV Infections, Europe, HIV Seropositivity, Cervix Neoplasms, Risk Factors, Hodgkin Disease, Italy, Liver Neoplasms, France, Risk, North America, Australia, Human, Female, Male, epidemiology, AIDS

Acrobat Reader Download PDF logo

2000-01-30
11

Copyright © 2000 - Foundation for Retrovirology and Human Health (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Foundation for Retrovirology and Human Health. Licensed from National Library of Medicine.