7th Conference on Retroviruses and Opportunistic Infections


San Francisco, CA - January 30 -February 4, 2000



PREVALENCE OF METABOLIC COMPLICATIONS IN A LARGE DIVERSE COHORT OF HIV-INFECTED PERSONS.

Conf Retroviruses Opportunistic Infect 2000 Jan 30-Feb 2; 7:77 (abstract no. 13)

W. M. El-Sadr, G. Collins, S. Raghavan, C. Rappoport, C. Gibert, A. Carr, And G. Bartsch
Community Programs for Clinical Research on AIDS (CPCRA), New York.

BACKGROUND: A range of prevalence rates of various metabolic complications of HIV or antiretroviral therapy (ART) has been reported. Uniformly collected data on diverse populations and on both ART naïve (ART/NAV) and ART experienced (ART/EXP) patients (pts) are needed.

METHODS: We evaluated all pts currently enrolled in CPCRA studies and calculated (in both ART/NAV and ART/EXP) the percentages with the following: diabetes mellitus (DM), coronary artery disease or stroke (CAD/STRK), or body habitus change (BHC). BHC included any of: the following: buffalo hump, peripheral lipodystrophy, increase in abdominal girth, and breast enlargement. Multivariate analyses were done to determine independent factors associated with each condition.

RESULTS: A total of 1,370 pts (331 ART/NAV and 1039 ART/EXP) were assessed, with a median age 40.2 years: 86% men, 34% African Americans, 12% Latino, 15% with a history of IDU, median CD4 348 cells/mm3 and median log HIV RNA 3.0 copies/ml.

Older age (p=0.001), non-whites (p=0.06), higher CD4 count (p=0.003) and higher HIV RNA level (p=0.02) were significantly associated with DM; older age (p=0.0001) was significantly associated with CAD/STRK; older age (p=0.005), white race (p=0.001) and ART/EXP (p=0.001) were significantly associated with BHC. In the one study with data on duration of ART, white race (p=0.04) and duration of ART (p=0.0001) were significantly associated with BHC, while protease inhibitor use was not.

CONCLUSIONS: Prevalence of BHC in this cohort was lower than reported previously. Older age was associated with DM and CAD/STRK. BHC was reported among ART/EXP but not among ART/NAV pts. White race and duration of ART were associated with BHC while protease inhibitor use was not.

Keywords: AEGIS, HIV, Prevalence, CD4 Lymphocyte Count, Anti-HIV Agents, HIV Infections, HIV-1, Lipodystrophy, HIV Protease Inhibitors, Whites, HIV Seronegativity, Antigens, CD4, HIV Seropositivity, Human, Male, complications, epidemiology, pathogenicity, immunology, AIDS

Acrobat Reader Download PDF logo

2000-01-30
13

Copyright © 2000 - Foundation for Retrovirology and Human Health (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Foundation for Retrovirology and Human Health. Licensed from National Library of Medicine.