AEGiS-07CROI: A pilot study of carotid intima media thickness in HIV-infected women treated with protease inhibitors.

7th Conference on Retroviruses and Opportunistic Infections

San Francisco, CA - January 30 -February 4, 2000

A PILOT STUDY OF CAROTID INTIMA MEDIA THICKNESS IN HIV-INFECTED WOMEN TREATED WITH PROTEASE INHIBITORS.

Conf Retroviruses Opportunistic Infect 2000 Jan 30-Feb 2; 7:81 (abstract no. 32)

J. S. Currier, D. L. Johnson, M. Dube, and H. Hodis
Univ. California, Los Angeles, and Univ. of Southern California

BACKGROUND: The long term effects of antiretroviral therapy-induced metabolic changes remains uncertain. A precise and reproducible measure of carotid intima media thickness (IMT), a non-invasive ultrasound (UTZ) technique, has correlated with coronary atherosclerosis.

METHODS: 15 HIV infected women were matched by age and ethnicity to 15 HIV seronegative (neg) women. Subjects were excluded if they smoked, had DM or HTN. All of the women were < 35 years of age and premenopausal.

RESULTS: The mean CD4 cell count was 436 ± 50 and the median vRNA was <50 c/mL. The mean duration of PI use was 11 ± 6 months. The mean weight for the HIV+ women was 164 ± 14 lbs compared to 147 ± 7 lbs for HIV-neg women. Mean fasting TG in the HIV+ 239 ± 352 mg/dl and the HIV-neg were 92 ± 54; Chol in the HIV+ were 224 ± 161mg/dl and the HIV-neg were 165 ± 19; HDL levels were 42 ± 9 mg/dl in the HIV+ and 56 ± 12 in the HIV-neg; LDL were 117 ± 36 mg/dl in the HIV+ and 93 ± 14 in the HIV-neg. Among the 11 pairs with completed IMT UTZ, the HIV+ were 0.586 ± 0.065 mm and for the HIV-neg 0.579 ± 0.052. IMT were greater among the HIV+ compared to the control in 4 pairs, the same in 3 and less thick in 4 pairs.

CONCLUSION: In this small matched case control study, despite the higher rates of abnormal lipids, no differences were observed in IMT values (p=ns). While limited by the small sample size, there was no evidence of accelerated atherosclerosis among women on PI for a mean of 12 months. Larger studies with longer term follow-up are needed.

Keywords: AEGIS, Tunica Media, Tunica Intima, HIV, Arteriosclerosis, Protease Inhibitors, Lipoproteins, LDL, HIV-1, HIV Infections, Lipids, Case-Control Studies, Human, Female, AIDS

2000-01-30
32

Copyright © 2000 - Foundation for Retrovirology and Human Health (IAS). Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Foundation for Retrovirology and Human Health. Licensed from National Library of Medicine.