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8th Conference on Retroviruses and Opportunistic InfectionsChicago, IL - February 4 - 8, 2001 |
Conf Retroviruses Opportunistic Infect 2001 Feb 4-8; 8:53 (abstract no. 35)
E. S. Daar1, H. Lynn2, S. Donfield2, E. D. Gomperts3, M. W. Hilgartner4, W. K. Hoots5, D. Chernoff6, S. Arkin7, W.-Y. Wong3, and C. Winkler8
1Cedars-Sinai Med. Ctr./Univ. of California, Los Angeles; 2Rho, Inc., Chapel Hill, NC; 3Children's Hosp., Los Angeles, CA; 4New York Hosp.-Cornell Med. Ctr., New York; 5Univ. of Texas Med. Sch., Houston; 6Chiron Corp., Emeryville, CA; 7Schneider Children's Hosp., New York, NY; and 8SAIC, FCRDC-NCI, Frederick, MD.
BACKGROUND: Little is known regarding the determinants of HCV clearance, vl, and ALT levels in HIV-infected and uninfected individuals.
METHODS: We studied 207 HIV-infected and 121 uninfected hemophiliacs with HCV infection who in 1989-1990 enrolled in the Hemophilia Growth and Development Study. CD4+ cells, HCV vl, and ALT were measured annually in all subjects, with HIV vl measured annually in those HIV-infected. HIV and HCV vl were measured using bDNA version 2.0 assays (Chiron, Emeryville, CA), with lower limits of detection of 500 and 200,000 copies/ml, respectively. HCV clearance was defined as being repeatedly bDNA negative and undetectable by qualitative RT-PCR (COBAS).
RESULTS: HCV clearance was more frequent in the HIV-uninfected, younger and hepatitis B surface antigen (HbsAg) negative individuals. Adjusted odds ratios for HCV clearance were 4.79 (95% CI: 1.63-14.08, p=0.005), 1.23 (95% CI: 1.04-1.47, p=0.017), and 3.20 (95% CI: 0.98- 10.42, p=0.054), respectively. Mean HCV vl at enrollment were different, 6.10 and 6.67 log10 copies/ml in those HIV-uninfected and infected, respectively (p<0.001), with the difference persisting during 7 years of follow-up. Every 100 cell increase in CD4+ cells was associated with a 35% decrease in HCV vl (p=0.002). Moreover, every 10-fold increase in baseline HIV vl was associated with a 72% increase in HCV vl (p=0.008). Finally, HCV vl and ALT levels correlated, with every 100-fold increase in baseline HCV associated with a 15% increase in ALT (p<0.001).
CONCLUSIONS: We show that HCV clearance is associated with age, HIV, and HbsAg status. In addition, CD4+ cells are inversely correlated with HCV vl, and HCV vl is directly related to hepatic inflammation as measured by ALT levels.
2001-02-04
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Copyright © 2001 - Foundation for Retrovirology and Human Health. Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Foundation for Retrovirology and Human Health. Licensed (AIDSLINE) from National Library of Medicine.