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8th Conference on Retroviruses and Opportunistic Infections
Chicago, IL - February 4 - 8, 2001
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Role of P-glycoprotein in CNS and genital tract penetration
Conf Retroviruses Opportunistic Infect 2001 Feb 4-8; 8:280 (abstract no. S1)
Kim R; Vanderbilt Univ Sch of Med, Nashville, TN.
HIV protease inhibitors have proven remarkably effective in treating HIV-1 infection. However, some tissues such as the brain and testes (sanctuary sites) are possibly protected from exposure to HIV protease inhibitors (HIV-PIs) due to drug entry being limited by the membrane efflux transporter P-glycoprotein (P-gp, encoded by MDR1), located in the capillary endothelium. A general review of P-gp expression and function, including the recently described genetic polymorphisms in MDR1, will be followed by data on the use of P-gp inhibitors as a way to enhance HIV-PI levels in organs such as the brain. Our studies suggest that both the potency and specificity of a P-gp inhibitor are important determinants for selectively enhancing the CNS and testes entry of HIV-PIs.
Keywords: AEGIS, HIV Protease Inhibitors, Phosphatidylserines, Central Nervous System, P-Glycoprotein, Glycoproteins, HIV Infections, Brain, AIDS
2001-02-04
S1
Copyright © 2001 - Foundation for Retrovirology and Human Health. Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Foundation for Retrovirology and Human Health. Licensed (AIDSLINE) from National Library of Medicine.