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8th Conference on Retroviruses and Opportunistic Infections
Chicago, IL - February 4 - 8, 2001
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Mucosal T-cell immunity in HIV-1 infection and vaccination
Conf Retroviruses Opportunistic Infect 2001 Feb 4-8; 8:281 (abstract no. S6)
McElrath MJ; Fred Hutchinson Cancer Res Ctr, Seattle, WA.
Acquisition of HIV-1 infection occurs predominantly by sexual transmission. The factors essential for the prevention or control of HIV-1 infection in the mucosa are not well understood. Mucosal T cells may provide an important immune defense against local infection. Our studies demonstrate that HIV-1-specific class I MHC-restricted CD8+ CTL reside in the cervical mucosa of women and semen and rectal mucosa of men who have HIV-1 infection. Recent studies have determined the epitope specificities and TCR usage of mucosal antigen-specific T cells, and these appear generally similar to those in peripheral blood. MHC-restricted cytolysis by HIV-1-specific mucosal CD8+ T cells is dependent upon perform activity. Studies are underway to determine if mucosal T cell effectors contribute to the local control of virus replication and to assess the induction of these activities by vaccination.
Keywords: AEGIS, HIV Infections, Immunity, Mucosal, HIV-1, T-Lymphocytes, Vaccination, Antigens, CD8, CD8-Positive T-Lymphocytes, CD4-Positive T-Lymphocytes, T-Lymphocytes, Cytotoxic, Major Histocompatibility Complex, Virus Replication, Immunization, Epitopes, Mucous Membrane, Receptors, Antigen, T-Cell, Human, Female, Male, immunology, genetics, virology, AIDS
2001-02-04
S6
Copyright © 2001 - Foundation for Retrovirology and Human Health. Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Foundation for Retrovirology and Human Health. Licensed (AIDSLINE) from National Library of Medicine.