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8th Conference on Retroviruses and Opportunistic Infections
Chicago, IL - February 4 - 8, 2001
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DNA-MVA/HIVA: A candidate HIV vaccine for Kenya
Conf Retroviruses Opportunistic Infect 2001 Feb 4-8; 8:282 (abstract no. S8)
Hanke T; Inst Molecular Med, Oxford, UK.
Human immunodeficiency virus, the causative agent of AIDS, continues to spread throughout the world at an alarming rate. Development of a safe, efficient, affordable preventative HIV vaccine is the best hope for a long-term control of this pandemics. Using recent advances in biological and medical sciences, a novel candidate HIV vaccine has been developed and is about to enter clinical evaluation in Oxford followed by a similar trial in Nairobi, Kenya later this year. This vaccine has two components, DNA and MVA (an attenuated poxvirus), used in a prime-boost vaccination protocol. Both of these components express a common "chimeric" immunogen. HIVA derived from small parts of the HIV genome. It focuses on the induction of cell-mediated immune responses, which are believed to play an important role in fighting the HIV virus. This candidate vaccine contrasts the current HIV vaccine efforts that have entered human trials. Most of the over 25 different HIV vaccines tested in humans, so far, focused on the induction of neutralizing antibodies and used proteins derived from the European/North American isolates. The Oxford vaccine focuses on the induction of cellular immune responses and employs a protein immunogen tailor-designed for Nairobi.
Keywords: AEGIS, AIDS Vaccines, HIV, HIV Antibodies, Vaccines, DNA, HIV Core Protein p24, HIV Infections, Acquired Immunodeficiency Syndrome, HIV Antigens, DNA, Simian Acquired Immunodeficiency Syndrome, Vaccination, Genetic Vectors, Kenya, Human, AIDS
2001-02-04
S8
Copyright © 2001 - Foundation for Retrovirology and Human Health. Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Foundation for Retrovirology and Human Health. Licensed (AIDSLINE) from National Library of Medicine.