9th Conference on Retroviruses and Opportunistic Infections Seattle, Washington - February 24 -February 28, 2002

Conf Retroviruses Opportunistic Infect 2002 Feb 24-28;9:abstract no. L9
Ashley Haase
Univ. of Minnesota Med. Sch., Minneapolis

This presentation will focus on how access, substrate availability, and spatial proximity affect transmission and propagation of SIV and HIV infection in vivo. A description of the first in rhesus macaque SIV model of heterosexual transmission, the role of preexisting inflammation in creating a "leaky" mucosal barrier, the different roles of resting and activated CD4⁺ T cells in transmission, virus production, and the dynamics of infection, based on evidence derived from new amplification technologies to visualize virus production. The presentation will conclude with a discussion of how virus-specific CD8, CTLs, and other factors profoundly alter levels of virus gene expression in vivo vis-a-vis infection of cell cultures.

020224
L9

Copyright © 2002 - Foundation for Retrovirology and Human Health. Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Foundation for Retrovirology and Human Health. Licensed (AIDSLINE) from National Library of Medicine.