AEGiS-11CROI: Progressive White Matter Loss Suggests Ongoing Brain Injury in ART-treated HIV+ Patients

11th Conference on Retroviruses and Opportunistic Infections

San Francisco, California - February 8 - 11, 2004

Progressive White Matter Loss Suggests Ongoing Brain Injury in ART-treated HIV+ Patients

Conf Retroviruses Opportunistic Infect. 2004 Feb 8-11;11th:Abstract No. 33LB

M W Weiner¹, D J Meyerhoff¹, V Cardenas-Nicolson¹, J Kornak¹, C Studholme¹, D Truran¹, J Rothlind¹, L Chao¹, H Lampiris¹, R Grant⁴, and J Lindgren¹
¹VA Med. Ctr., Univ. of California, San Francisco, USA and ⁴San Francisco General Hosp., Gladstone Inst. of Virology and Immunology, Univ. of California, San Francisco, USA

BACKGROUND: Prior to ART, the CNS was a major target of HIV, often producing dementia. Since introduction of ART, CNS complications of HIV have been much less severe. Nevertheless, there has been concern that CNS injury may occur despite ART treatment. Therefore, the goal of this longitudinal study was to test the hypothesis of ongoing CNS injury in both light drinking (LD) and heavy drinking (HD) ART-treated HIV+ subjects compared with HIV- controls.

METHODS: To measure CNS injury, all subjects had structural MRI, MR spectroscopy, neuropsychological tests, and EEG evoked response at 2 time points. Data were analyzed using linear mixed effects models. The demographics of the 4 subject groups are shown in the table:

	N	Age	% Male	Interscan Interval (years)	CD4 Count	Log VL
HIV- LD	45	41±8	64	2.05±0.21	813±280	N/A
HIV- HD	24	43±10	83	1.84±0.16	895±314	N/A

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33LB

Copyright © 2004 - Foundation for Retrovirology and Human Health. Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Foundation for Retrovirology and Human Health. Licensed (AIDSLINE) from National Library of Medicine.