[25] VIRAL LOAD (VL) AND CD4 RESPONSE TO PI CONTAINING REGIMEN IN B VERSUS NON-B TREATMENT-naïve HIV-1 PATIENTS (P)

2nd International AIDS Society Conference on HIV Pathogenesis and Treatment

Paris, France - July 13 - 16, 2003

[TITLE:] VIRAL LOAD (VL) AND CD4 RESPONSE TO PI CONTAINING REGIMEN IN B VERSUS NON-B TREATMENT-naïve HIV-1 PATIENTS (P)

[AUTHOR(S):] S De Wit¹, R Boulmé², B Poll¹, JC Schmit² and N Clumeck¹
¹Saint-Pierre University Hospital, Belgium; and ²ABL Advanced Biological Laboratories and CRP-Santé, Luxembourg

IAS Conf HIV Pathog Treat 2003 Jul 13-16;2nd: Abstract No. 25
Antiviral Therapy 2003; 8(Suppl. 1):S190

[ABSTRACT:] We compared the response to PI-containing HAART in B vs non-B HIV-1 naïve p. as measured by the proportion of p. with VL< 400 copies/ml and median (Md) change from baseline (BL) CD4 cell count at month (m)24. RT and PR sequencing was done by HIV ViroSeq (ABI) and viral subtype characterisation by ABL i-Subtyping and HIV-SEQ Stanford University and NCBI. Chi-square, Wilcoxon/Kruskall Wallis and Fisher’s exact tests were used. All naïve p. (n=175) starting therapy between 9/94 and 7/01 with 2 NRTIs+ 1 PI were retrieved: there were 56 B p. and 119 non-B p., including subtypes A(21p), C(25p), D(8p), G(8p), H(2p), J(1p), recombinant forms (AE 7p,AG 22p) and mosaics (22p). Most B p. were Caucasians (90%) homosexual (71%) whereas most non-B p. were Africans (89%) heterosexual (100%). Md BL VL (4.8log) and CD4 (250/µl) were comparable in both g. No difference in the % of p. with VL< 400 c/ml was observed at m24 in B vs non-B groups (52% vs 64% ITT-missing=failure). Md VL decline at m24 was –2.0 vs –1.9log. There was a significant difference in Md change CD4 at m24 (B:+235 vs non-B:+161, P<0.02). This difference was mainly found in B vs A (and A containing) subtypes. The HIV population starting therapy in Belgium shows a high heterogeneity of sub-types. No difference in VL response at m24 to a PI-containing regimen was found between B and non-B sub-types whereas CD4 response was lower in the non-B p., particularly those with A sub-type. Whether this is due to viral or immune factors warrants further investigation.

030714
25