2nd International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV 13-15 September 2000, Toronto, Canada

LACTATE LEVELS IN HIV-POSITIVE PATIENTS UNDER ANTIRETROVIRAL TREATMENT

Antiviral Therapy 2000; 5(Suppl. 5):32 (abstract no. P14)

F Blanco, F Laguna, T Garcia-Benayas, V Soriano, V Moreno, E Valencia, MJ Senchordi and J Glez-Lahoz
Instituto de Salud Carlos III, Madrid, Spain

BACKGROUND: Hyperlactataemia is a newly recognized adverse event of antiretroviral therapy. Its prevalence, severity, risk factors and clinical relevance are not well defined.

OBJECTIVES: To analyse the levels of serum lactate, regarding the clinical, metabolic and therapeutic profile in a group of HIV-positive patients receiving antiretroviral treatment.

DESIGN: Cross-sectional study of 127 HIV-positive patients under antiretroviral therapy for >6 months. Venous lactataemia (normal values <16 mg/dl), demographic data, risk behaviour for HIV infection, lipodystrophy (LD) morphological changes, lipid levels, immunological state and drug regimens as well as total duration of antiretroviral treatments were recorded.

RESULTS: Mean age 38±7 years, male 69%. Mean lactate 18.5±6.5 mg/dl (range, 7.2-39.3). Overall, hyperlactataemia was recognized in 60%. Statistically significant differences between patients with hyperversus normolactataemia were found for the following variables: male gender (67 versus 33%), homosexual practices (54 versus 19%), IDU (30 versus 61 %), mean triglyceride levels (286±283 versus 161±131 mg/dl) , mean cholesterol levels (236±67 versus 205±52 mg/dl), morphological LD changes (75 versus 39%), and time on HAART (25±13 versus 17±13 months). CD4 cell count, transaminase levels, percentage of HCV-infected patients, duration of antiretroviral treatment, and time on nucleoside analogues did not show significant differences between the two groups.

CONCLUSIONS: Hyperlactataemia is quite common among HIV-positive patients under antiretroviral treatment. In the univariate analysis, male gender, homosexual behaviour, time on HAART, hyperlipaemia and morphological LD changes are all conditions associated with high lactate levels.

000913
P14

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