2nd International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV 13-15 September 2000, Toronto, Canada

CARDIOVASCULAR RISK IN HIV-POSITIVE PATIENTS WITH HAART-RELATED DYSLIPIDAEMIA

Antiviral Therapy 2000; 5(Suppl. 5):27 (abstract no. P6)

T Garcia-Benayas, F Blanco, A Barrios, J de la Cruz, J Sánchez, V Soriano and J Glez-Lahoz
Instituto de Salud Carlos III, Madrid, Spain

BACKGROUND: Dyslipidaemia is a quite common disturbance in HIV-positive patients on HAART. This condition implies an increased risk for cardiovascular (CV) events in the general population. In HIV-positive subjects it should be important to rule out and control other CV risk factors in order to prevent CV damage.

OBJECTIVES: To describe the prevalence of CV risk factors in HIV-positive patients under HAART with dyslipidaemia.

DESIGN: Cross-sectional study of 234 HIV-positive patients on HAART, with either hypercholesterolaemia (HC; cholesterol >200 mg/dl) and/or hypertriglyceridaemia (HT; triglycerides [tg] >200 mg/dl). The presence of other CV risk factors was recorded: hypertension, diabetes, overweight/obesity (BMI: 25-29.9/>30 kg/m², respectively), alcohol abuse (>40 g/day), smoking, physical inactivity and family history.

RESULTS: Mean age 40±8 years, male 82%. Homosexuals 54%, IDU 32%, heterosexuals 12%. Mean CD4 cell count 565±285 cells/mm³ (23±8%). HC was present in 85% (mean cholesterol value: 265±43 mg/dl) and HT in 64% (mean tg value: 424±251 mg/dl) (P=0.001). Both HC and HT were present in 58%. Other CV risk factors: hypertension in 10%, diabetes in 3%, overweight in 26% and obesity in 4%, alcohol abuse in 4%, smoking in 66%, physical inactivity in 29% and family history of CV diseases in 73 %. One patient referred previous vasoespastic angor.

CONCLUSIONS: In HIV-positive subjects under HAART with dyslipidaemia, hypercholesterolaemia is more prevalent than hypertriglyceridaemia, although both are present in more than half of patients. The association with other CV risk factors was remarkable, being most frequently a family history of CV disease and smoking, followed by physical inactivity and overweight. These findings should alert clinicians on the importance of diagnosing and controlling other CV risk factors in HIV-positive patients under HAART with dyslipidaemia, in order to prevent future CV morbidity.

000913
P6

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