4th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV 22-25 September 2002, San Diego, CA, USA

The lipodystrophy syndrome of HIV patients is characterized by a progressive syndrome of abnormal body fat distribution accompanied by hypertriglyceridaemia. In the course of clinical HIV genotype testing, we observed that our HIV patients with hypertriglyceridaemia had viral genotypes that were more highly mutated than those of therapy-matched control patients. Hypertriglyceridaemia was statistically associated with predicted resistance for three nucleoside reverse transcriptase inhibitors, zidovudine, abacavir, and stavudine. Statistical analysis of 51 patients in retrospect revealed a strong association of mutations at reverse transcriptase codons M41 and T215 with hypertriglyceridaemia (χ² 8.375, P=0.0038, and χ² 7.445, P=0.0064, respectively). This was in contrast to silent mutations, which occurred at equivalent rates in retroviral genotypes of patients with and without hypertriglyceridaemia. The findings imply that the HIV genotype itself may be a significant etiologic factor in antiretroviral-associated lipodystrophy.

Presenting author: SJ Anderson

2002-09-22
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