5th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV 8–11 July 2003, Le Meridien Montparnasse, Paris, France

HIGH PREVALENCE OF HYPERTENSION IN HIV-INFECTED PATIENTS

Antiviral Therapy 2003; 8:L32 (abstract 40)

J Santos, R Palacios, J Ruiz, M Gonzalez and M Marquez
Hospital Virgen de la Victoria, Malaga, Spain

OBJECTIVE: To analyse the prevalence of systolic (SH) and diastolic hypertension (DH) in a cohort of HIV-infected patients and identify related factors.

METHODS: A transversal study of all outpatients who attended the institution between 05/02–09/02 was undertaken. Demographic features, tobacco use, lipid profile, personal and familial history of ischaemic heart disease and epidemiological, clinical, immunovirological and therapeutic characteristics related to HIV infection were collected. Multiple logistic regression was used to identify factors associated with SH and DH (JNC VI, Arch Intern Med 1997; statistical programme, SPSS).

RESULTS: Six-hundred-and-one patients. Mean age, 42.1 years; men, 80.8%; sexual transmission of HIV, 60.7%; AIDS, 40.3%; antiretroviral (ARV) users 81.1%, for a mean time of 59.4 (1–149) months; SH, 24% and DH, 19%. Patients with SH were older (40.3 vs 32.8; P<0.0001), had a higher body mass index (BMI) (25.1 vs 23.1; P<0.0001) and sexual HIV transmission was the most frequent HIV risk (76.7 vs 57.3%; P< 0.0001). Multivariate analysis: age [odds ratio (OR) 0.94; 95% confidence interval (CI): 0.92–0.96; P<0.00001], BMI (OR 0.89; 95% CI: 0.84–0.94; P<0.0001) and tobacco use (OR 1.69; 95% CI: 1.08–2.63; P<0.01) were significant. Patients with DH were also older (39.0 vs 33.6 years; P<0.0001), had higher BMI (25.4 vs 23.2; P<0.0001) and sexual HIV transmission was predominant (74.5 vs 59.0%; P<0.002); they also had higher levels of total cholesterol (203 vs 183; P<0.001), high-density lipoprotein cholesterol (HDL-C) (48 vs 43; P<0.01) and low-density lipoprotein cholesterol (LDL-C) (111 vs 103; P<0.01). Multivariate analysis: age (OR 0.95; 95% CI: 0.93–0.97; P<0.0001), BMI (OR 0.85; 95% CI: 0.79–0.91; P<0.00001) and HDL-C (OR 0.97; 95% CI: 0.96–0.99; P<0.0022) were significant. Clinical, immunovirological and therapeutic features related to HIV infection were not associated with SH or DH.

CONCLUSIONS: The prevalence of SH and DH in our HIV-infected patients is high. Both SH and DH are associated with classic risk factors. It is important to measure blood pressure in these patients periodically. Although we have not observed any relation between HIV infection and/or HAART and SH/DH, prospective studies with a better analysis of their influence on blood pressure are needed.

Presenting author: J Santos

2003-07-08
40

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