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7th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV13–16 November 2005, Dublin, Ireland |
METABOLIC SYNDROME AND HIV: COMPARISON WITH THE PREVALENCE IN THE GENERAL POPULATION (SIMONE VS PAMELA)
P Bonfanti1, R Facchetti2, S Melzi3, M Bombelli2, L Cordier1, M Franzetti4, H Polo Friz2, C Sfara5, T Quirino3 and R Sega2
1 Luigi Sacco Hospital, Milan, Italy; 2Milano-Bicocca University, Milan, Italy; 3 Busto Arsizio Hospital, Busto Arsizio, Italy; 4 Padova Hospital, Padova, Italy; Perugia Hospital, Perugia, Italy
Antiviral Therapy 2005; Supplement 3:L23 (abstract no. 33)
BACKGROUND: The Metabolic Syndrome (MS) is increasingly regarded as an emerging risk factor in the overall assessment of cardiovascular risk, but figures on its prevalence among HIV-infected patients, compared with the general population, still tend to differ.
OBJECTIVES: To compare the prevalence of MS in HIV-positive patients and a sample of the general population.
METHODS: We compared the PAMELA database (a survey conducted in Italy on the general population) with the SIMONE study findings in Italian HIV+ patients. We used the NCEP definition of MS, making the diagnosis when a person fulfilled three or more of the following criteria: waist measurement >102 cm for men and >88 cm for women; high triglycerides (=150mg/dl); low HDL cholesterol (<40mg/dl for men, <50mg/ml for women); hypertension (=135/=85 mmHg); high blood glucose (=110mg/ml).
RESULTS: We studied 1243 HIV+ patients in the SIMONE study (71.8% males; mean age 43.1 years) and 1922 in the PAMELA survey (50.2% males; mean age 50.7 years). The HIV+ patients had a significantly higher prevalence of MS than the general population (respectively 22.28% and 15.76%, P<0.0001); this difference remained after adjusting for sex and age and also when only treatment-naïve patients were analysed. The prevalence was higher for males and females, and for any stratum of age. Triglycerides, HDL cholesterol and blood glucose were more frequently abnormal in the SIMONE patients with MS than in the general population which, however, had higher proportions of hypertensive subjects and people with a larger waist measurement.
CONCLUSIONS: MS was more frequent among HIV+ subjects than in the general population. This probably reflects the metabolic changes related to the HIV infection and its treatment.
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2005-11-13
33
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