7th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV 13–16 November 2005, Dublin, Ireland

OFFICE-BASED ASSESSMENT OF BODY COMPOSITION ABNORMALITIES IN PATIENTS UNDER HAART

WH Belloso¹, ML Sanchez¹, MR Ajzenszlos¹, GD Lopardo², AM Galich¹, P Fainstein Day¹, D Torres¹, IM Otegui¹, LD Stern¹ and LO Clara^1
1 Hospital Italiano de Buenos Aires, Buenos Aires Argentina; ² Fundacion Centro de Estudios Infectologicos, Buenos Aires, Argentina

Antiviral Therapy 2005; Supplement 3:L24 (abstract no. 35)

BACKGROUND: lthough a universal definition of lipodystrophy is not yet available, there are some body composition parameters that are considered relevant for assessment of alterations in body fat distribution. Total body fat, subcutaneous and visceral fat and peripheral fat mass are usually analysed in the search of antiretroviral drug consequences on body composition. Imaging methods are frequently used for these evaluations. We analysed the correlation between inexpensive office-based methods (anthropometry and bioimpedance – BIA) with imaging methods for the assessment of different body composition parameters.

METHODS: Cross-sectional study performed in the lipodystrophy assessment cohort followed at the Hospital Italiano de Buenos Aires. After confirmation of normal distribution, variables were analysed through Pearson correlation and linear regression test.

RESULTS: At one particular moment 103 patients had multiple evaluations done (anthropometry, BIA, DEXA and abdominal CT scan). 29/103 (28%) were female and mean age was 40.4 years. Total body fat assessed by BIA showed a correlation of 0.9 with DEXA scan. Waist perimeter had a correlation of 0.61 with CT scan visceral fat and 0.69 with Trunk Fat by DEXA. Thigh perimeter showed a correlation of 0.63 with leg fat by DEXA and subcutaneous fat by CT scan had a correlation of 0.57 with the sum of skinfolds (0.69 in men).

CONCLUSIONS: Some but not all relevant parameters of body composition can be accurately assessed by office-based inexpensive methods in HIV-positive patients. Subcutaneous fat values are more precisely predicted in men.

Download PDF of this abstract.

2005-11-13
35

Copyright © 2005 - International Medical Press Ltd. Reproduction of this abstract (other than one copy for personal reference) must be cleared through the Medical Editor, International Medical Press, 36 St Mary-at-Hill, London EC3R 8DU, United Kingdom.