13th Annual Conference of the British HIV Association 29 March–1 April 2007, Brighton, UK

A SURVEY OF VACCINATION HISTORY AND IMMUNE STATUS IN HIV-INFECTED PERSONS

HIV Med 2007; 8(Suppl. 1):3 (abstract no. O12)

James Molton, Kevin Stonebanks, Gaia Nebbia, Ian Cropley, Mike Youle, Margaret Johnson and Anna Maria Geretti
Royal Free and University College Medical School, London, UK

BACKGROUND: Recent BHIVA immunization guidelines are the first internationally that specifically target HIV-infected adults. Data on knowledge of and susceptibility to vaccine-preventable infections in HIV-infected adults are limited.

AIM: Assess knowledge among HIV-infected patients of previous infection and vaccination and determine IgG seroprevalence for vaccine-preventable infections.

METHODS: Questionnaires were issued to 100 consecutive patients at a London clinic. Samples were tested for IgG against measles, mumps, rubella, VZV, hepatitis A and B (surface and core). Results were correlated to demographic and clinical data.

RESULTS: Of 100 patients, 73 were male, 61 were born in the UK/Europe, 28 Africa. Self-reported vaccination rates were; tetanus 75%, polio 57%, diphtheria 42%, BCG 42%, pneumococcus 7%, influenza 52%. Reported past infection or vaccination was measles 70%, mumps 57%, and rubella 46%, with seroprevalence of 90%, 87% and 93% respectively. VZV IgG seroprevalence was 92%, with 62% recalling a history of chickenpox or shingles. Of 33 individuals reporting hepatitis A vaccination, 27% had undetectable IgG, while 19 who reported past infection all had detectable IgG. For hepatitis B, 52 reported vaccination and 37% had a surface Ab level >10 IU/I. With both hepatitis A and B mean CD4 counts were lower in seronegative than seropositive persons. Fewer than 25% with serological evidence of past hepatitis B infection reported this. Reported travel vaccine uptake was; live attenuated yellow fever 25% (with no reported adverse events), rabies 4%, typhoid 24%, and Japanese encephalitis 1%.

CONCLUSIONS: A significant number of HIV-infected adults are at risk of vaccine-preventable infections and should be identified and offered vaccination. Many are unaware of their vaccination status and education may be beneficial.

2007-03-29
O12

Copyright © 2007 - British HIV Association (BHIVA) Reproduction of this abstract (other than one copy for personal reference) must be cleared through the BHIVA Organising Secretariat 1 Mountview Court, 310 Friern Barnet Lane, London N20 0LD